Shane Falcinelli, MD, PhD

Title(s)RESIDENT, Pathology
SchoolSchool of Medicine
Address505 Parnassus Avenue, #M580
San Francisco CA 94117
ORCID ORCID Icon0000-0002-3554-226X Additional info
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    Collapse Biography 
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    University of North Carolina, Chapel Hill, NCMD/PhD05/2024Microbiology & Immunology

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    Reducing the HIV Reservoir: Next-Generation Latency Reversal Agents and T Cell Population Targets
    NIH F30AI145588Apr 1, 2019 - Mar 31, 2024
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy. Elife. 2024 Sep 09; 13. Semenova L, Wang Y, Falcinelli S, Archin N, Cooper-Volkheimer AD, Margolis DM, Goonetilleke N, Murdoch DM, Rudin CD, Browne EP. PMID: 39250423; PMCID: PMC11383529.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy. bioRxiv. 2024 Jun 25. Semenova L, Wang Y, Falcinelli S, Archin N, Cooper-Volkheimer AD, Margolis DM, Goonetilleke N, Murdoch DM, Rudin CD, Browne EP. PMID: 38014340; PMCID: PMC10680759.
      View in: PubMed   Mentions:
    3. Nanoparticle delivery of Tat synergizes with classical latency reversal agents to express HIV antigen targets. Antimicrob Agents Chemother. 2024 Jul 09; 68(7):e0020124. Raines SLM, Falcinelli SD, Peterson JJ, Van Gulck E, Allard B, Kirchherr J, Vega J, Najera I, Boden D, Archin NM, Margolis DM. PMID: 38829049; PMCID: PMC11232404.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. The Effects of Human Immunodeficiency Virus Type 1 (HIV-1) Antigen-Expanded Specific T-Cell Therapy and Vorinostat on Persistent HIV-1 Infection in People With HIV on Antiretroviral Therapy. J Infect Dis. 2024 Mar 14; 229(3):743-752. Gay CL, Hanley PJ, Falcinelli SD, Kuruc JD, Pedersen SM, Kirchherr J, Raines SLM, Motta CM, Lazarski C, Chansky P, Tanna J, Shibli A, Datar A, McCann CD, Sili U, Ke R, Eron JJ, Archin N, Goonetilleke N, Bollard CM, Margolis DM. PMID: 38349333; PMCID: PMC10938201.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    5. Transient CD4+ T cell depletion during suppressive ART reduces the HIV reservoir in humanized mice. PLoS Pathog. 2023 Dec; 19(12):e1011824. Ling L, De C, Spagnuolo RA, Begum N, Falcinelli SD, Archin NM, Kovarova M, Silvestri G, Wahl A, Margolis DM, Garcia JV. PMID: 38055722; PMCID: PMC10699604.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Impact of Cannabis Use on Immune Cell Populations and the Viral Reservoir in People With HIV on Suppressive Antiretroviral Therapy. J Infect Dis. 2023 11 28; 228(11):1600-1609. Falcinelli SD, Cooper-Volkheimer AD, Semenova L, Wu E, Richardson A, Ashokkumar M, Margolis DM, Archin NM, Rudin CD, Murdoch D, Browne EP. PMID: 37606598; PMCID: PMC10681869.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    7. HIVepsilon-seq-scalable characterization of intact persistent proviral HIV reservoirs in women. J Virol. 2023 11 30; 97(11):e0070523. Barton K, Ferguson JM, Deveson IW, Falcinelli SD, James KS, Kirchherr J, Ramirez C, Gay CL, Hammond JM, Bevear B, Carswell SL, Margolis DM, Smith MA, Adimora AA, Archin NM. PMID: 37843370; PMCID: PMC10688329.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques. Nat Med. 2023 10; 29(10):2535-2546. Dashti A, Sukkestad S, Horner AM, Neja M, Siddiqi Z, Waller C, Goldy J, Monroe D, Lin A, Schoof N, Singh V, Mavigner M, Lifson JD, Deleage C, Tuyishime M, Falcinelli SD, King HAD, Ke R, Mason RD, Archin NM, Dunham RM, Safrit JT, Jean S, Perelson AS, Margolis DM, Ferrari G, Roederer M, Silvestri G, Chahroudi A. PMID: 37783968; PMCID: PMC10579098.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    9. Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo. J Clin Invest. 2022 04 15; 132(8). Falcinelli SD, Peterson JJ, Turner AW, Irlbeck D, Read J, Raines SL, James KS, Sutton C, Sanchez A, Emery A, Sampey G, Ferris R, Allard B, Ghofrani S, Kirchherr JL, Baker C, Kuruc JD, Gay CL, James LI, Wu G, Zuck P, Rioja I, Furze RC, Prinjha RK, Howell BJ, Swanstrom R, Browne EP, Strahl BD, Dunham RM, Archin NM, Margolis DM. PMID: 35426377; PMCID: PMC9012286.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    10. Stable Latent HIV Infection and Low-level Viremia Despite Treatment With the Broadly Neutralizing Antibody VRC07-523LS and the Latency Reversal Agent Vorinostat. J Infect Dis. 2022 03 02; 225(5):856-861. Gay CL, James KS, Tuyishime M, Falcinelli SD, Joseph SB, Moeser MJ, Allard B, Kirchherr JL, Clohosey M, Raines SLM, Montefiori DC, Shen X, Gorelick RJ, Gama L, McDermott AB, Koup RA, Mascola JR, Floris-Moore M, Kuruc JD, Ferrari G, Eron JJ, Archin NM, Margolis DM. PMID: 34562096; PMCID: PMC8889279.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCellsCTClinical Trials
    11. Crotonylation sensitizes IAPi-induced disruption of latent HIV by enhancing p100 cleavage into p52. iScience. 2022 Jan 21; 25(1):103649. Li D, Dewey MG, Wang L, Falcinelli SD, Wong LM, Tang Y, Browne EP, Chen X, Archin NM, Margolis DM, Jiang G. PMID: 35024584; PMCID: PMC8728431.
      View in: PubMed   Mentions: 9  
    12. Longitudinal Dynamics of Intact HIV Proviral DNA and Outgrowth Virus Frequencies in a Cohort of Individuals Receiving Antiretroviral Therapy. J Infect Dis. 2021 07 02; 224(1):92-100. Falcinelli SD, Kilpatrick KW, Read J, Murtagh R, Allard B, Ghofrani S, Kirchherr J, James KS, Stuelke E, Baker C, Kuruc JD, Eron JJ, Hudgens MG, Gay CL, Margolis DM, Archin NM. PMID: 33216132; PMCID: PMC8253129.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    13. Sequence Evaluation and Comparative Analysis of Novel Assays for Intact Proviral HIV-1 DNA. J Virol. 2021 02 24; 95(6). Gaebler C, Falcinelli SD, Stoffel E, Read J, Murtagh R, Oliveira TY, Ramos V, Lorenzi JCC, Kirchherr J, James KS, Allard B, Baker C, Kuruc JD, Caskey M, Archin NM, Siliciano RF, Margolis DM, Nussenzweig MC. PMID: 33361426; PMCID: PMC8094944.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    14. Impact of Biological Sex on Immune Activation and Frequency of the Latent HIV Reservoir During Suppressive Antiretroviral Therapy. J Infect Dis. 2020 11 09; 222(11):1843-1852. Falcinelli SD, Shook-Sa BE, Dewey MG, Sridhar S, Read J, Kirchherr J, James KS, Allard B, Ghofrani S, Stuelke E, Baker C, Roan NR, Eron JJ, Kuruc JD, Ramirez C, Gay C, Mollan KR, Margolis DM, Adimora AA, Archin NM. PMID: 32496542; PMCID: PMC7653086.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    15. Cellular Gene Modulation of HIV-Infected CD4 T Cells in Response to Serial Treatment with the Histone Deacetylase Inhibitor Vorinostat. J Virol. 2020 06 16; 94(13). Maxwell JW, Falcinelli SD, Nefedov A, Dorfmeier C, Wu G, Dewey M, Webber AL, Archin NM, Margolis DM, Hazuda DJ, Barnard RJO, Howell BJ. PMID: 32295913; PMCID: PMC7307144.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection. Sci Rep. 2020 03 20; 10(1):5134. Gay CL, Kuruc JD, Falcinelli SD, Warren JA, Reifeis SA, Kirchherr JL, James KS, Dewey MG, Helms A, Allard B, Stuelke E, Gamble A, Plachco A, Gorelick RJ, Eron JJ, Hudgens M, Garrido C, Goonetilleke N, DeBenedette MA, Tcherepanova IY, Nicolette CA, Archin NM, Margolis DM. PMID: 32198428; PMCID: PMC7083965.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCellsPHPublic Health
    17. CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption. Nat Med. 2020 04; 26(4):519-528. Harper J, Gordon S, Chan CN, Wang H, Lindemuth E, Galardi C, Falcinelli SD, Raines SLM, Read JL, Nguyen K, McGary CS, Nekorchuk M, Busman-Sahay K, Schawalder J, King C, Pino M, Micci L, Cervasi B, Jean S, Sanderson A, Johns B, Koblansky AA, Amrine-Madsen H, Lifson J, Margolis DM, Silvestri G, Bar KJ, Favre D, Estes JD, Paiardini M. PMID: 32284611; PMCID: PMC7790171.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    18. Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo. Nature. 2020 02; 578(7793):160-165. Nixon CC, Mavigner M, Sampey GC, Brooks AD, Spagnuolo RA, Irlbeck DM, Mattingly C, Ho PT, Schoof N, Cammon CG, Tharp GK, Kanke M, Wang Z, Cleary RA, Upadhyay AA, De C, Wills SR, Falcinelli SD, Galardi C, Walum H, Schramm NJ, Deutsch J, Lifson JD, Fennessey CM, Keele BF, Jean S, Maguire S, Liao B, Browne EP, Ferris RG, Brehm JH, Favre D, Vanderford TH, Bosinger SE, Jones CD, Routy JP, Archin NM, Margolis DM, Wahl A, Dunham RM, Silvestri G, Chahroudi A, Garcia JV. PMID: 31969707; PMCID: PMC7111210.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    19. New Frontiers in Measuring and Characterizing the HIV Reservoir. Front Microbiol. 2019; 10:2878. Falcinelli SD, Ceriani C, Margolis DM, Archin NM. PMID: 31921056; PMCID: PMC6930150.
      View in: PubMed   Mentions: 36  
    20. Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus. Viruses. 2019 01 29; 11(2). Nickol ME, Ciric J, Falcinelli SD, Chertow DS, Kindrachuk J. PMID: 30699912; PMCID: PMC6409999.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    21. The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy. J Vis Exp. 2017 11 24; (129). Chua J, Fisher NA, Falcinelli SD, DeShazer D, Friedlander AM. PMID: 29286449; PMCID: PMC5755476.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    22. Green tea and epigallocatechin-3-gallate are bactericidal against Bacillus anthracis. FEMS Microbiol Lett. 2017 07 03; 364(12). Falcinelli SD, Shi MC, Friedlander AM, Chua J. PMID: 28605495.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Integration of Global Analyses of Host Molecular Responses with Clinical Data To Evaluate Pathogenesis and Advance Therapies for Emerging and Re-emerging Viral Infections. ACS Infect Dis. 2016 11 11; 2(11):787-799. Falcinelli SD, Chertow DS, Kindrachuk J. PMID: 27933782; PMCID: PMC6131701.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    24. A Novel Strategy to Reverse General Anesthesia by Scavenging with the Acyclic Cucurbit[n]uril-type Molecular Container Calabadion 2. Anesthesiology. 2016 08; 125(2):333-45. Diaz-Gil D, Haerter F, Falcinelli S, Ganapati S, Hettiarachchi GK, Simons JC, Zhang B, Grabitz SD, Moreno Duarte I, Cotten JF, Eikermann-Haerter K, Deng H, Chamberlin NL, Isaacs L, Briken V, Eikermann M. PMID: 27341276; PMCID: PMC4955735.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    25. Acyclic Cucurbit[n]uril-Type Molecular Containers: Influence of Linker Length on Their Function as Solubilizing Agents. ChemMedChem. 2016 05 06; 11(9):980-9. Sigwalt D, Moncelet D, Falcinelli S, Mandadapu V, Zavalij PY, Day A, Briken V, Isaacs L. PMID: 26990780; PMCID: PMC4861662.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    26. Acyclic Cucurbit[n]uril-Type Molecular Container Enables Systemic Delivery of Effective Doses of Albendazole for Treatment of SK-OV-3 Xenograft Tumors. Mol Pharm. 2016 Mar 07; 13(3):809-18. Hettiarachchi G, Samanta SK, Falcinelli S, Zhang B, Moncelet D, Isaacs L, Briken V. PMID: 26756920; PMCID: PMC4783263.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    27. Characterization of the host response to pichinde virus infection in the Syrian golden hamster by species-specific kinome analysis. Mol Cell Proteomics. 2015 Mar; 14(3):646-57. Falcinelli S, Gowen BB, Trost B, Napper S, Kusalik A, Johnson RF, Safronetz D, Prescott J, Wahl-Jensen V, Jahrling PB, Kindrachuk J. PMID: 25573744; PMCID: PMC4349984.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    28. Systems kinomics for characterizing host responses to high-consequence pathogens at the NIH/NIAID Integrated Research Facility-Frederick. Pathog Dis. 2014 Jul; 71(2):190-98. Kindrachuk J, Falcinelli S, Wada J, Kuhn JH, Hensley LE, Jahrling PB. PMID: 24585711; PMCID: PMC6136422.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
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