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Timothy Henrich, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Phone415-206-5518
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    Collapse Biography 
    Collapse Education and Training
    Yale UniversityM.D.2004School of Medicine
    Harvard UniversityM.M.Sc.2013School of Medicine
    Oberlin CollegeB.A.1996
    Brigham and Women's HospitalInternal Medicine Residency2007
    Massachusetts General Hospital and Brigham and Women's HospitalInfectious Disease Fellowship2009

    Collapse Overview 
    Collapse Overview
    My laboratory/research group specializes in immunmodulatory, cytoreductive chemotherapeutic and stem cell transplantation approaches to HIV-1 cure. We are also involved in the design and implementation of novel nano/microtechnologies and PET-based imaging approaches to characterize viral reservoirs.

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting Non Viral Markers of HIV Persistence
    NIH/NIAID R01AI141003May 15, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Biomarkers of CNS HIV Persistence
    NIH/NIMH R21MH116716Mar 1, 2018 - Jan 31, 2020
    Role: Principal Investigator
    Targeting latent HIV-1 Reservoirs with the Antibody-Drug Conjugate, Brentuximab Vedotin
    NIH/NIAID R33AI116205Sep 1, 2016 - Aug 31, 2019
    Role: Principal Investigator
    Single Cell Characterization of Latent HIV-1 Reservoirs
    NIH/NIAID R01AI122862Aug 2, 2016 - Jul 31, 2020
    Role: Principal Investigator
    Measurement of Antibody Epitope Signatures by Peptide Microarrays to Determine Recency of HIV Infection
    NIH/NIAID R21AI122938Jun 24, 2016 - May 31, 2018
    Role: Co-Principal Investigator
    Targeting latent HIV-1 Reservoirs with the Antibody-Drug Conjugate, Brentuximab Vedotin
    NIH/NIAID R21AI116205Sep 1, 2014 - Aug 31, 2016
    Role: Principal Investigator
    A Novel Microfluidic HIV-1 Co-Culture Assay to Quantify Latent Reservoirs
    NIH/NIAID R21AI113117Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Microfluidic PCR Method to Identify and Characterize HIV-Infected Single Cells
    NIH/NIAID R21AI110277Jun 1, 2014 - May 31, 2016
    Role: Principal Investigator
    Impact of Chemotherapy and Stem Cell Transplant on HIV-1 Reservoir Dynamics
    NIH/NIAID K23AI098480Mar 1, 2012 - Feb 28, 2017
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wang CC, Thanh C, Gibson EA, Ball-Burack M, Hogan LE, Descours B, Jones N, Carvidi AB, Munter S, Bakkour S, Busch MP, Milush JM, Deeks SG, Henrich TJ. Transient loss of detectable HIV-1 RNA following brentuximab vedotin anti-CD30 therapy for Hodgkin lymphoma. Blood Adv. 2018 Dec 11; 2(23):3479-3482. PMID: 30530753.
      View in: PubMed
    2. Henrich TJ, Lelièvre JD. Progress towards obtaining an HIV cure: slow but sure. Curr Opin HIV AIDS. 2018 Sep; 13(5):381-382. PMID: 29965799.
      View in: PubMed
    3. Hogan LE, Körner C, Hobbs K, Simoneau CR, Thanh C, Gibson EA, Palmer CD, Pandit A, Marty FM, Kuritzkes DR, Jost S, Ritz J, Henrich TJ. NK-cell activation is associated with increased HIV transcriptional activity following allogeneic hematopoietic cell transplantation. Blood Adv. 2018 Jun 26; 2(12):1412-1416. PMID: 29921650.
      View in: PubMed
    4. Hogan LE, Hanhauser E, Hobbs KS, Palmer CD, Robles Y, Jost S, LaCasce AS, Abramson J, Hamdan A, Marty FM, Kuritzkes DR, Henrich TJ. Human Herpes Virus 8 in HIV-1 infected individuals receiving cancer chemotherapy and stem cell transplantation. PLoS One. 2018; 13(5):e0197298. PMID: 29746555.
      View in: PubMed
    5. Henrich TJ. Dolutegravir intensification and HIV persistence: 3?+?1?=?3. Lancet HIV. 2018 05; 5(5):e201-e202. PMID: 29643012.
      View in: PubMed
    6. Hogan LE, Vasquez J, Hobbs KS, Hanhauser E, Aguilar-Rodriguez B, Hussien R, Thanh C, Gibson EA, Carvidi AB, Smith LCB, Khan S, Trapecar M, Sanjabi S, Somsouk M, Stoddart CA, Kuritzkes DR, Deeks SG, Henrich TJ. Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+ T cells expressing CD30. PLoS Pathog. 2018 02; 14(2):e1006856. PMID: 29470552.
      View in: PubMed
    7. Vasquez JJ, Hussien R, Aguilar-Rodriguez B, Junger H, Dobi D, Henrich TJ, Thanh C, Gibson E, Hogan LE, McCune J, Hunt PW, Stoddart CA, Laszik ZG. Elucidating the Burden of HIV in Tissues Using Multiplexed Immunofluorescence and In Situ Hybridization: Methods for the Single-Cell Phenotypic Characterization of Cells Harboring HIV In Situ. J Histochem Cytochem. 2018 Jun; 66(6):427-446. PMID: 29462571.
      View in: PubMed
    8. Henrich TJ, Hatano H, Bacon O, Hogan LE, Rutishauser R, Hill A, Kearney MF, Anderson EM, Buchbinder SP, Cohen SE, Abdel-Mohsen M, Pohlmeyer CW, Fromentin R, Hoh R, Liu AY, McCune JM, Spindler J, Metcalf-Pate K, Hobbs KS, Thanh C, Gibson EA, Kuritzkes DR, Siliciano RF, Price RW, Richman DD, Chomont N, Siliciano JD, Mellors JW, Yukl SA, Blankson JN, Liegler T, Deeks SG. HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study. PLoS Med. 2017 Nov; 14(11):e1002417. PMID: 29112956.
      View in: PubMed
    9. Henrich TJ, Hobbs KS, Hanhauser E, Scully E, Hogan LE, Robles YP, Leadabrand KS, Marty FM, Palmer CD, Jost S, Körner C, Li JZ, Gandhi RT, Hamdan A, Abramson J, LaCasce AS, Kuritzkes DR. Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for Malignancy. J Infect Dis. 2017 07 15; 216(2):254-262. PMID: 28838149.
      View in: PubMed
    10. Hill AL, Rosenbloom DIS, Goldstein E, Hanhauser E, Kuritzkes DR, Siliciano RF, Henrich TJ. Correction: Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV. PLoS Pathog. 2017 Jul; 13(7):e1006488. PMID: 28683094.
      View in: PubMed
    11. Yucha RW, Hobbs KS, Hanhauser E, Hogan LE, Nieves W, Ozen MO, Inci F, York V, Gibson EA, Thanh C, Shafiee H, El Assal R, Kiselinova M, Robles YP, Bae H, Leadabrand KS, Wang S, Deeks SG, Kuritzkes DR, Demirci U, Henrich TJ. High-throughput Characterization of HIV-1 Reservoir Reactivation Using a Single-Cell-in-Droplet PCR Assay. EBioMedicine. 2017 Jun; 20:217-229. PMID: 28529033.
      View in: PubMed
    12. Charlins P, Schmitt K, Remling-Mulder L, Hogan LE, Hanhauser E, Hobbs KS, Hecht F, Deeks SG, Henrich TJ, Akkina R. A humanized mouse-based HIV-1 viral outgrowth assay with higher sensitivity than in vitro qVOA in detecting latently infected cells from individuals on ART with undetectable viral loads. Virology. 2017 07; 507:135-139. PMID: 28432928.
      View in: PubMed
    13. Henrich TJ, Deeks SG, Pillai SK. Measuring the Size of the Latent Human Immunodeficiency Virus Reservoir: The Present and Future of Evaluating Eradication Strategies. J Infect Dis. 2017 Mar 15; 215(suppl_3):S134-S141. PMID: 28520968.
      View in: PubMed
    14. Deeks SG, Lewin SR, Ross AL, Ananworanich J, Benkirane M, Cannon P, Chomont N, Douek D, Lifson JD, Lo YR, Kuritzkes D, Margolis D, Mellors J, Persaud D, Tucker JD, Barre-Sinoussi F, Alter G, Auerbach J, Autran B, Barouch DH, Behrens G, Cavazzana M, Chen Z, Cohen ÉA, Corbelli GM, Eholié S, Eyal N, Fidler S, Garcia L, Grossman C, Henderson G, Henrich TJ, Jefferys R, Kiem HP, McCune J, Moodley K, Newman PA, Nijhuis M, Nsubuga MS, Ott M, Palmer S, Richman D, Saez-Cirion A, Sharp M, Siliciano J, Silvestri G, Singh J, Spire B, Taylor J, Tolstrup M, Valente S, van Lunzen J, Walensky R, Wilson I, Zack J. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat Med. 2016 08; 22(8):839-50. PMID: 27400264.
      View in: PubMed
    15. Patel KP, Vaidya A, Gibson CJ, Henrich TJ, Lyons JL. INTERACTIVE MEDICAL CASE. A Woman with Dyspnea and Altered Mental Status. N Engl J Med. 2016 Jun 09; 374(23):e29. PMID: 27276581.
      View in: PubMed
    16. Lifson MA, Ozen MO, Inci F, Wang S, Inan H, Baday M, Henrich TJ, Demirci U. Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring. Adv Drug Deliv Rev. 2016 08 01; 103:90-104. PMID: 27262924.
      View in: PubMed
    17. Hill AL, Rosenbloom DI, Goldstein E, Hanhauser E, Kuritzkes DR, Siliciano RF, Henrich TJ. Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV. PLoS Pathog. 2016 04; 12(4):e1005535. PMID: 27119536.
      View in: PubMed
    18. Zhang J, Gao X, Martin J, Rosa B, Chen Z, Mitreva M, Henrich T, Kuritzkes D, Ratner L. Evolution of coreceptor utilization to escape CCR5 antagonist therapy. Virology. 2016 07; 494:198-214. PMID: 27128349; PMCID: PMC4913893.
      View in: PubMed, PubMed Central
    19. Sugarman J, Lewin SR, Henrich TJ, Rasmussen TA. Ethics of ART interruption after stem-cell transplantation. Lancet HIV. 2016 Jan; 3(1):e8-10. PMID: 26762996.
      View in: PubMed
    20. Henrich TJ, Hanhauser E, Harrison LJ, Palmer CD, Romero-Tejeda M, Jost S, Bosch RJ, Kuritzkes DR. CCR5-?32 Heterozygosity, HIV-1 Reservoir Size, and Lymphocyte Activation in Individuals Receiving Long-term Suppressive Antiretroviral Therapy. J Infect Dis. 2016 Mar 01; 213(5):766-70. PMID: 26512140; PMCID: PMC4747624 [Available on 03/01/17].
      View in: PubMed, PubMed Central
    21. Rosenbloom DI, Elliott O, Hill AL, Henrich TJ, Siliciano JM, Siliciano RF. Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1. Open Forum Infect Dis. 2015 Dec; 2(4):ofv123. PMID: 26478893; PMCID: PMC4602119.
      View in: PubMed, PubMed Central
    22. Inci F, Filippini C, Baday M, Ozen MO, Calamak S, Durmus NG, Wang S, Hanhauser E, Hobbs KS, Juillard F, Kuang PP, Vetter ML, Carocci M, Yamamoto HS, Takagi Y, Yildiz UH, Akin D, Wesemann DR, Singhal A, Yang PL, Nibert ML, Fichorova RN, Lau DT, Henrich TJ, Kaye KM, Schachter SC, Kuritzkes DR, Steinmetz LM, Gambhir SS, Davis RW, Demirci U. Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4354-63. PMID: 26195743.
      View in: PubMed
    23. Shafiee H, Kanakasabapathy MK, Juillard F, Keser M, Sadasivam M, Yuksekkaya M, Hanhauser E, Henrich TJ, Kuritzkes DR, Kaye KM, Demirci U. Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva. Sci Rep. 2015 Jun 05; 5:9919. PMID: 26046668; PMCID: PMC4456945.
      View in: PubMed, PubMed Central
    24. Henrich TJ. HIV eradication: is cord blood the answer? Lancet HIV. 2015 Jun; 2(6):e219-20. PMID: 26423188.
      View in: PubMed
    25. Henrich TJ, Hanhauser E, Hu Z, Stellbrink HJ, Noah C, Martin JN, Deeks SG, Kuritzkes DR, Pereyra F. Viremic control and viral coreceptor usage in two HIV-1-infected persons homozygous for CCR5 ?32. AIDS. 2015 May 15; 29(8):867-76. PMID: 25730507; PMCID: PMC4473772.
      View in: PubMed, PubMed Central
    26. Shafiee H, Wang S, Inci F, Toy M, Henrich TJ, Kuritzkes DR, Demirci U. Emerging technologies for point-of-care management of HIV infection. Annu Rev Med. 2015; 66:387-405. PMID: 25423597.
      View in: PubMed
    27. Henrich TJ, Hanhauser E, Marty FM, Sirignano MN, Keating S, Lee TH, Robles YP, Davis BT, Li JZ, Heisey A, Hill AL, Busch MP, Armand P, Soiffer RJ, Altfeld M, Kuritzkes DR. Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases. Ann Intern Med. 2014 Sep 02; 161(5):319-27. PMID: 25047577; PMCID: PMC4236912.
      View in: PubMed, PubMed Central
    28. Al-Hajjar SH, Frayha HH, Al-Hazmi M, Batawi R, McIntosh K, Sax PE, Al-Thawadi S, Al-Jumaah S, Busch MP, Hanhauser E, Kuritzkes DR, Li JZ, Henrich TJ. Prevention of HIV-1 transmission with postexposure prophylaxis after inadvertent infected blood transfusion. AIDS. 2014 Jun 19; 28(10):1539-41. PMID: 24896805; PMCID: PMC4226216.
      View in: PubMed, PubMed Central
    29. Henrich TJ, McLaren PJ, Rao SS, Lin NH, Hanhauser E, Giguel F, Gulick RM, Ribaudo H, de Bakker PI, Kuritzkes DR. Genome-Wide Association Study of Human Immunodeficiency Virus (HIV)-1 Coreceptor Usage in Treatment-Naive Patients from An AIDS Clinical Trials Group Study. Open Forum Infect Dis. 2014 Mar; 1(1):ofu018. PMID: 25734091; PMCID: PMC4324186.
      View in: PubMed, PubMed Central
    30. Shafiee H, Lidstone EA, Jahangir M, Inci F, Hanhauser E, Henrich TJ, Kuritzkes DR, Cunningham BT, Demirci U. Nanostructured optical photonic crystal biosensor for HIV viral load measurement. Sci Rep. 2014 Feb 28; 4:4116. PMID: 24576941; PMCID: PMC3937800.
      View in: PubMed, PubMed Central
    31. Buzon MJ, Sun H, Li C, Shaw A, Seiss K, Ouyang Z, Martin-Gayo E, Leng J, Henrich TJ, Li JZ, Pereyra F, Zurakowski R, Walker BD, Rosenberg ES, Yu XG, Lichterfeld M. HIV-1 persistence in CD4+ T cells with stem cell-like properties. Nat Med. 2014 Feb; 20(2):139-42. PMID: 24412925; PMCID: PMC3959167.
      View in: PubMed, PubMed Central
    32. Henrich TJ, Gandhi RT. Early treatment and HIV-1 reservoirs: a stitch in time? J Infect Dis. 2013 Oct 15; 208(8):1189-93. PMID: 23852126; PMCID: PMC3778963.
      View in: PubMed, PubMed Central
    33. Henrich TJ, Hu Z, Li JZ, Sciaranghella G, Busch MP, Keating SM, Gallien S, Lin NH, Giguel FF, Lavoie L, Ho VT, Armand P, Soiffer RJ, Sagar M, Lacasce AS, Kuritzkes DR. Long-term reduction in peripheral blood HIV type 1 reservoirs following reduced-intensity conditioning allogeneic stem cell transplantation. J Infect Dis. 2013 Jun 01; 207(11):1694-702. PMID: 23460751; PMCID: PMC3636784.
      View in: PubMed, PubMed Central
    34. Henrich TJ, Kuritzkes DR. HIV-1 entry inhibitors: recent development and clinical use. Curr Opin Virol. 2013 Feb; 3(1):51-7. PMID: 23290628.
      View in: PubMed
    35. Henrich TJ, Wood BR, Kuritzkes DR. Increased risk of virologic rebound in patients on antiviral therapy with a detectable HIV load <48 copies/mL. PLoS One. 2012; 7(11):e50065. PMID: 23166820; PMCID: PMC3499490.
      View in: PubMed, PubMed Central
    36. Henrich TJ, Gallien S, Li JZ, Pereyra F, Kuritzkes DR. Low-level detection and quantitation of cellular HIV-1 DNA and 2-LTR circles using droplet digital PCR. J Virol Methods. 2012 Dec; 186(1-2):68-72. PMID: 22974526; PMCID: PMC3517891.
      View in: PubMed, PubMed Central
    37. Wood BR, Klein JP, Lyons JL, Milner DA, Phillips RE, Schutten M, Folkerth RD, Ciarlini P, Henrich TJ, Johnson JA. HIV-2 encephalitis: case report and literature review. AIDS Patient Care STDS. 2012 Jul; 26(7):383-7. PMID: 22694171.
      View in: PubMed
    38. Henrich TJ, Lewine NR, Lee SH, Rao SS, Berro R, Gulick RM, Moore JP, Tsibris AM, Kuritzkes DR. Differential use of CCR5 by HIV-1 clinical isolates resistant to small-molecule CCR5 antagonists. Antimicrob Agents Chemother. 2012 Apr; 56(4):1931-5. PMID: 22252820; PMCID: PMC3318367.
      View in: PubMed, PubMed Central
    39. Tsibris AM, Pal U, Schure AL, Veazey RS, Kunstman KJ, Henrich TJ, Klasse PJ, Wolinsky SM, Kuritzkes DR, Moore JP. SHIV-162P3 infection of rhesus macaques given maraviroc gel vaginally does not involve resistant viruses. PLoS One. 2011; 6(12):e28047. PMID: 22164225; PMCID: PMC3229503.
      View in: PubMed, PubMed Central
    40. Henrich TJ, Yawetz S. Impact of age, gender, and pregnancy on syphilis screening using the Captia Syphilis-G assay. Sex Transm Dis. 2011 Dec; 38(12):1126-30. PMID: 22082723.
      View in: PubMed
    41. Putcharoen O, Lee SH, Henrich TJ, Hu Z, Vanichanan J, Coakley E, Greaves W, Gulick RM, Kuritzkes DR, Tsibris AM. HIV-1 clinical isolates resistant to CCR5 antagonists exhibit delayed entry kinetics that are corrected in the presence of drug. J Virol. 2012 Jan; 86(2):1119-28. PMID: 22090117; PMCID: PMC3255837.
      View in: PubMed, PubMed Central
    42. Henrich TJ, Tsibris AM, Lewine NR, Konstantinidis I, Leopold KE, Sagar M, Kuritzkes DR. Evolution of CCR5 antagonist resistance in an HIV-1 subtype C clinical isolate. J Acquir Immune Defic Syndr. 2010 Dec; 55(4):420-7. PMID: 20856130; PMCID: PMC3070184.
      View in: PubMed, PubMed Central
    43. Henrich TJ, Li JZ, Felsenstein D, Kotton CN, Plenge RM, Pereyra F, Marty FM, Lin NH, Grazioso P, Crochiere DM, Eggers D, Kuritzkes DR, Tsibris AM. Xenotropic murine leukemia virus-related virus prevalence in patients with chronic fatigue syndrome or chronic immunomodulatory conditions. J Infect Dis. 2010 Nov 15; 202(10):1478-81. PMID: 20936980; PMCID: PMC2957553.
      View in: PubMed, PubMed Central
    44. Henrich TJ, Ribaudo HJ, Kuritzkes DR. Instantaneous inhibitory potential is similar to inhibitory quotient at predicting HIV-1 response to antiretroviral therapy. Clin Infect Dis. 2010 Jul 01; 51(1):93-8. PMID: 20504163; PMCID: PMC2880658.
      View in: PubMed, PubMed Central
    45. Morgan EA, Henrich TJ, Jarell AD, Shieh WJ, Zaki SR, Marty FM, Thorner AR, Milner DA, Velazquez EF. Infectious granulomatous dermatitis associated with Rothia mucilaginosa bacteremia: A case report. Am J Dermatopathol. 2010 Apr; 32(2):175-9. PMID: 19940746.
      View in: PubMed
    46. Henrich TJ, Marty FM, Milner DA, Thorner AR. Disseminated Geotrichum candidum infection in a patient with relapsed acute myelogenous leukemia following allogeneic stem cell transplantation and review of the literature. Transpl Infect Dis. 2009 Oct; 11(5):458-62. PMID: 19804480.
      View in: PubMed
    47. Tsibris AM, Paredes R, Chadburn A, Su Z, Henrich TJ, Krambrink A, Hughes MD, Aberg JA, Currier JS, Tashima K, Godfrey C, Greaves W, Flexner C, Skolnik PR, Wilkin TJ, Gulick RM, Kuritzkes DR. Lymphoma diagnosis and plasma Epstein-Barr virus load during vicriviroc therapy: results of the AIDS Clinical Trials Group A5211. Clin Infect Dis. 2009 Mar 01; 48(5):642-9. PMID: 19191652; PMCID: PMC2756462.
      View in: PubMed, PubMed Central
    48. Henrich TJ, Krakower D, Bitton A, Yokoe DS. Clinical risk factors for severe Clostridium difficile-associated disease. Emerg Infect Dis. 2009 Mar; 15(3):415-22. PMID: 19239754; PMCID: PMC2681109.
      View in: PubMed, PubMed Central
    49. Henrich TJ, Lauder N, Desai MM, Sofair AN. Association of alcohol abuse and injection drug use with immunologic and virologic responses to HAART in HIV-positive patients from urban community health clinics. J Community Health. 2008 Apr; 33(2):69-77. PMID: 18046634.
      View in: PubMed
    50. Henrich TJ, Hutchaleelaha S, Jiwariyavej V, Barbazan P, Nitatpattana N, Yoksan S, Gonzalez JP. Geographic dynamics of viral encephalitis in Thailand. Microbes Infect. 2003 Jun; 5(7):603-11. PMID: 12787736.
      View in: PubMed
    51. Nitatpattana N, Henrich T, Palabodeewat S, Tangkanakul W, Poonsuksombat D, Chauvancy G, Barbazan P, Yoksan S, Gonzalez JP. Hantaan virus antibody prevalence in rodent populations of several provinces of northeastern Thailand. Trop Med Int Health. 2002 Oct; 7(10):840-5. PMID: 12358618.
      View in: PubMed
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