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Nadia Roan, PhD

TitleAssociate Professor
InstitutionUniversity of California San Francisco
DepartmentUrology
Address1650 Owens St
San Francisco CA 94107
Phone415-734-4883
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    Collapse Biography 
    Collapse Awards and Honors
    NIH2017  - 2022P01AI131374. PI of P01: Greene, PI of Project 1: Roan
    NIH2016  - 2021R01AI127219. PI: Roan
    NIH2016  - 2018R21AI122821. PI: Roan
    NIH2015  - 2017R21AI116252. PI: Roan
    NIH2018  - 2023R01AI141003. PI: Henrich
    NIH2017  - 2020R15GM123447. PI: Jensen-Seaman
    amfAR2016  - 2021amfAR Cure Institute
    UCSF, NIH2016  - 2017NCTRI P50 Pilot Grant Award. PI: Roan
    NIH2016  - 2017WIHS W16036 PI: Yukl
    CFAR2014  - 2015Center for AIDS Research Basic Science HIV/AIDS grant
    NIH2013  - 2016K99/R00 (K99AI103262, R00AI104262). PI: Roan
    UCSF2013  - 2015Hellman Award for Early-Career Faculty
    NIH2012  - 2013KURe K12
    NIH2012  - 2017R01HD074511. PI: Pilcher
    CFAR2012Centers for AIDS Research Early Career Award of Excellence in Basic Research
    The J. David Gladstones Institutes2012Gladstone Institute of Virology and Immunology Award for Scientific Excellence
    A.P. Giannini Foundation2008  - 2010A.P. Giannini Foundation Postdoctoral Fellowship
    NIH2006Travel Award for the 11th International Symposium on Human Chlamydial Infections
    Harvard Medical School2004Manfred Karnovsky Fellowship Award
    U.C. Berkeley2001Outstanding Scholar Award
    NSF2001  - 2004National Science Foundation Pre-Doctoral Fellowship
    U.C. Berkeley2001F.H. Carpenter Memorial Price in Biochemistry
    U.C. Berkeley2001University Medal Finalist

    Collapse Overview 
    Collapse Overview
    The Roan Lab studies how intracellular and extracellular factors in the tissue microenvironment can affect infection by HIV, mucosal immunity, and reproductive health. We have demonstrated that genital and rectal fibroblasts, amongst the most abundant cells of the mucosa, potently increase HIV infection of T cells through at least two distinct mechanisms: promoting viral entry, and altering the cellular state of T cells to render them more permissive to viral replication. To characterize the molecular basis of how intrinsic and extrinsic perturbations can render some subsets of CD4+ T cells more susceptible than others to HIV infection, we are using a variety of global gene expression analysis approaches, including CyTOF and RNA-seq. These approaches are also being used to characterize the HIV latent reservoir and the nature of viral rebound upon antiretroviral treatment interruption. Another research interest in the lab is to understand how factors in seminal plasma affect reproductive health and susceptibility to sexually transmitted diseases.


    Collapse Research 
    Collapse Research Activities and Funding
    Targeting Non Viral Markers of HIV Persistence
    NIH/NIAID R01AI141003May 15, 2018 - Apr 30, 2023
    Role: Co-Investigator
    Exploiting the Host-HIV Interface To Identify Biomarkers Predicting Time to Viral Rebound after Treatment Interruption
    NIH/NIAID P01AI131374Aug 8, 2017 - Jul 31, 2022
    Role: Principal Investigator of Project 1
    Elucidating the mechanism of progesterone-induced permissivity in the upper female reproductive tract
    NIH/NIAID R01AI127219Sep 26, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Characterization of Exosomes From Semen of Uninfected and HIV-Infected Men
    NIH/NIAID R21AI122821Mar 1, 2016 - Feb 28, 2018
    Role: Principal Investigator
    Characterization of Gallic Acid as a Novel HIV Microbicide Candidate
    NIH/NIAID R21AI116252Jul 1, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization
    NIH/NIAID R00AI104262May 15, 2013 - Nov 30, 2016
    Role: Principal Investigator
    Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization
    NIH/NIAID K99AI104262May 15, 2013 - Apr 30, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Laustsen A, Bak RO, Krapp C, Kjær L, Egedahl JH, Petersen CC, Pillai S, Tang HQ, Uldbjerg N, Porteus M, Roan NR, Nyegaard M, Denton PW, Jakobsen MR. Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function. Nat Commun. 2018 Aug 30; 9(1):3525. PMID: 30166549.
      View in: PubMed
    2. Müller JA, Harms M, Krüger F, Groß R, Joas S, Hayn M, Dietz AN, Lippold S, von Einem J, Schubert A, Michel M, Mayer B, Cortese M, Jang KS, Sandi-Monroy N, Deniz M, Ebner F, Vapalahti O, Otto M, Bartenschlager R, Herbeuval JP, Schmidt-Chanasit J, Roan NR, Münch J. Semen inhibits Zika virus infection of cells and tissues from the anogenital region. Nat Commun. 2018 Jun 07; 9(1):2207. PMID: 29880824.
      View in: PubMed
    3. Röcker A, Roan NR, Yadav JK, Fändrich M, Münch J. Structure, function and antagonism of semen amyloids. Chem Commun (Camb). 2018 Jun 06. PMID: 29873340.
      View in: PubMed
    4. Roan NR. Resident T cells stand up to HIV. Sci Immunol. 2018 Jun 01; 3(24). PMID: 29858287.
      View in: PubMed
    5. Martin JW, Chen JC, Neidleman J, Tatsumi K, Hu J, Giudice LC, Greene WC, Roan NR. Potent and rapid activation of tropomyosin-receptor kinase A in endometrial stromal fibroblasts by seminal plasma. Biol Reprod. 2018 Mar 06. PMID: 29518187.
      View in: PubMed
    6. Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S. An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S31-S39. PMID: 28882052.
      View in: PubMed
    7. Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR. Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017 Jul 25; 20(4):984-998. PMID: 28746881.
      View in: PubMed
    8. Roan NR, Sandi-Monroy N, Kohgadai N, Usmani SM, Hamil KG, Neidleman J, Montano M, Ständker L, Röcker A, Cavrois M, Rosen J, Marson K, Smith JF, Pilcher CD, Gagsteiger F, Sakk O, O'Rand M, Lishko PV, Kirchhoff F, Münch J, Greene WC. Semen amyloids participate in spermatozoa selection and clearance. Elife. 2017 06 27; 6. PMID: 28653619.
      View in: PubMed
    9. Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 2017 Feb; 13(2):e1006163. PMID: 28207890.
      View in: PubMed
    10. Camus C, Matusali G, Bourry O, Mahe D, Aubry F, Bujan L, Pasquier C, Massip P, Ravel C, Zirafi O, Munch J, Roan NR, Pineau C, Dejucq-Rainsford N. Comparison of the effect of semen from HIV-infected and uninfected men on CD4+ T-cell infection. AIDS. 2016 May 15; 30(8):1197-208. PMID: 26854806; PMCID: PMC4856179.
      View in: PubMed, PubMed Central
    11. LoRicco JG, Xu CS, Neidleman J, Bergkvist M, Greene WC, Roan NR, Makhatadze GI. Gallic Acid Is an Antagonist of Semen Amyloid Fibrils That Enhance HIV-1 Infection. J Biol Chem. 2016 Jul 01; 291(27):14045-55. PMID: 27226574; PMCID: PMC4933164 [Available on 07/01/17].
      View in: PubMed, PubMed Central
    12. Bergman P, Roan NR, Römling U, Bevins CL, Münch J. Amyloid formation: functional friend or fearful foe? J Intern Med. 2016 Aug; 280(2):139-52. PMID: 27151743; PMCID: PMC4956559 [Available on 08/01/17].
      View in: PubMed, PubMed Central
    13. Müller JA, Zirafi O, Roan NR, Lee SJ, Münch J. Evaluation of EPI-X4 as a urinary peptide biomarker for diagnosis and prognosis of late acute GvHD. Bone Marrow Transplant. 2016 08; 51(8):1137-9. PMID: 27042833; PMCID: PMC4972659 [Available on 02/01/17].
      View in: PubMed, PubMed Central
    14. Roan NR, Jakobsen MR. Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract. Curr HIV/AIDS Rep. 2016 Feb; 13(1):53-63. PMID: 26879654.
      View in: PubMed
    15. Chen JC, Roan NR. Isolation and Culture of Human Endometrial Epithelial Cells and Stromal Fibroblasts. Bio Protoc. 2015 Oct 20; 5(20). PMID: 27347495.
      View in: PubMed
    16. Roan NR, Münch J. Improving preclinical models of HIV microbicide efficacy. Trends Microbiol. 2015 Aug; 23(8):445-7. PMID: 26250616; PMCID: PMC4818646.
      View in: PubMed, PubMed Central
    17. Zirafi O, Kim KA, Roan NR, Kluge SF, Müller JA, Jiang S, Mayer B, Greene WC, Kirchhoff F, Münch J. Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides. Sci Transl Med. 2014 Nov 12; 6(262):262ra157. PMID: 25391483; PMCID: PMC4372245.
      View in: PubMed, PubMed Central
    18. French KC, Roan NR, Makhatadze GI. Structural characterization of semen coagulum-derived SEM1(86-107) amyloid fibrils that enhance HIV-1 infection. Biochemistry. 2014 May 27; 53(20):3267-77. PMID: 24811874; PMCID: PMC4039337.
      View in: PubMed, PubMed Central
    19. Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, Münch J, Witkowska HE, Greene WC. Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection. J Virol. 2014 Jul; 88(13):7221-34. PMID: 24741080; PMCID: PMC4054457.
      View in: PubMed, PubMed Central
    20. Roan NR, Chu S, Liu H, Neidleman J, Witkowska HE, Greene WC. Interaction of fibronectin with semen amyloids synergistically enhances HIV infection. J Infect Dis. 2014 Oct 01; 210(7):1062-6. PMID: 24719472; PMCID: PMC4168303.
      View in: PubMed, PubMed Central
    21. Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher CD, Gagsteiger F, Fändrich M, Kirchhoff F, Münch J. Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nat Commun. 2014 Apr 01; 5:3508. PMID: 24691351; PMCID: PMC4129123.
      View in: PubMed, PubMed Central
    22. Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, Kohgadai N, Irwin JC, Greene WC, Giudice LC, Roan NR. Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts. Hum Reprod. 2014 Jun; 29(6):1255-70. PMID: 24626806; PMCID: PMC4017943.
      View in: PubMed, PubMed Central
    23. Tang Q, Roan NR, Yamamura Y. Seminal plasma and semen amyloids enhance cytomegalovirus infection in cell culture. J Virol. 2013 Dec; 87(23):12583-91. PMID: 24027327; PMCID: PMC3838150.
      View in: PubMed, PubMed Central
    24. Yolamanova M, Meier C, Shaytan AK, Vas V, Bertoncini CW, Arnold F, Zirafi O, Usmani SM, Müller JA, Sauter D, Goffinet C, Palesch D, Walther P, Roan NR, Geiger H, Lunov O, Simmet T, Bohne J, Schrezenmeier H, Schwarz K, Ständker L, Forssmann WG, Salvatella X, Khalatur PG, Khokhlov AR, Knowles TP, Weil T, Kirchhoff F, Münch J. Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses. Nat Nanotechnol. 2013 Feb; 8(2):130-6. PMID: 23334171.
      View in: PubMed
    25. Roan NR, Cavrois M, Greene WC. [Role of semen-derived amyloid fibrils as facilitators of HIV infection]. Med Sci (Paris). 2012 Apr; 28(4):358-60. PMID: 22549858.
      View in: PubMed
    26. Roan NR, Müller JA, Liu H, Chu S, Arnold F, Stürzel CM, Walther P, Dong M, Witkowska HE, Kirchhoff F, Münch J, Greene WC. Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection. Cell Host Microbe. 2011 Dec 15; 10(6):541-50. PMID: 22177559; PMCID: PMC3257029.
      View in: PubMed, PubMed Central
    27. Arnold F, Schnell J, Zirafi O, Stürzel C, Meier C, Weil T, Ständker L, Forssmann WG, Roan NR, Greene WC, Kirchhoff F, Münch J. Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection. J Virol. 2012 Jan; 86(2):1244-9. PMID: 22090109; PMCID: PMC3255800.
      View in: PubMed, PubMed Central
    28. Kim KA, Yolamanova M, Zirafi O, Roan NR, Staendker L, Forssmann WG, Burgener A, Dejucq-Rainsford N, Hahn BH, Shaw GM, Greene WC, Kirchhoff F, Münch J. Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI. Retrovirology. 2010 Jun 23; 7:55. PMID: 20573198; PMCID: PMC2914040.
      View in: PubMed, PubMed Central
    29. Roan NR, Sowinski S, Münch J, Kirchhoff F, Greene WC. Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection). J Biol Chem. 2010 Jan 15; 285(3):1861-9. PMID: 19897482; PMCID: PMC2804344.
      View in: PubMed, PubMed Central
    30. Gondek DC, Roan NR, Starnbach MN. T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis. J Immunol. 2009 Jul 15; 183(2):1313-9. PMID: 19561106; PMCID: PMC2723820.
      View in: PubMed, PubMed Central
    31. Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC. The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J Virol. 2009 Jan; 83(1):73-80. PMID: 18945786; PMCID: PMC2612336.
      View in: PubMed, PubMed Central
    32. Starnbach MN, Roan NR. Conquering sexually transmitted diseases. Nat Rev Immunol. 2008 Apr; 8(4):313-7. PMID: 18309315.
      View in: PubMed
    33. Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang JH, Bell GW, Starnbach MN, Ploegh HL. Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3831-6. PMID: 18245382; PMCID: PMC2268777.
      View in: PubMed, PubMed Central
    34. Roan NR, Greene WC. A seminal finding for understanding HIV transmission. Cell. 2007 Dec 14; 131(6):1044-6. PMID: 18083095.
      View in: PubMed
    35. Roan NR, Starnbach MN. Immune-mediated control of Chlamydia infection. Cell Microbiol. 2008 Jan; 10(1):9-19. PMID: 17979983.
      View in: PubMed
    36. Roan NR, Starnbach MN. Antigen-specific CD8+ T cells respond to Chlamydia trachomatis in the genital mucosa. J Immunol. 2006 Dec 01; 177(11):7974-9. PMID: 17114470.
      View in: PubMed
    37. Roan NR, Gierahn TM, Higgins DE, Starnbach MN. Monitoring the T cell response to genital tract infection. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12069-74. PMID: 16880389; PMCID: PMC1567698.
      View in: PubMed, PubMed Central
    38. Balsara ZR, Roan NR, Steele LN, Starnbach MN. Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen. J Infect Dis. 2006 May 15; 193(10):1459-63. PMID: 16619195.
      View in: PubMed
    39. Hess D, Liu B, Roan NR, Sternglanz R, Winston F. Spt10-dependent transcriptional activation in Saccharomyces cerevisiae requires both the Spt10 acetyltransferase domain and Spt21. Mol Cell Biol. 2004 Jan; 24(1):135-43. PMID: 14673149; PMCID: PMC303362.
      View in: PubMed, PubMed Central
    40. D'Orazio SE, Velasquez M, Roan NR, Naveiras-Torres O, Starnbach MN. The Listeria monocytogenes lemA gene product is not required for intracellular infection or to activate fMIGWII-specific T cells. Infect Immun. 2003 Dec; 71(12):6721-7. PMID: 14638756; PMCID: PMC308916.
      View in: PubMed, PubMed Central
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