-
Longitudinal changes in the transcriptionally active and intact HIV reservoir after starting ART during acute infection. J Virol. 2025 Feb 05; e0143124.
Janssens J, Wedrychowski A, Kim SJ, Isbell C, Hoh R, Pillai SK, Henrich TJ, Deeks SG, Roan NR, Lee SA, Yukl SA. PMID: 39907283.
View in:
PubMed Mentions:
-
Anatomical, subset, and HIV-dependent expression of viral sensors and restriction factors. Cell Rep. 2025 Jan 10; 44(1):115202.
George AF, Neidleman J, Luo X, Frouard J, Elphick N, Yin K, Young KC, Ma T, Andrew AK, Ezeonwumelu IJ, Pedersen JG, Chaillon A, Porrachia M, Woodworth B, Jakobsen MR, Thomas R, Smith DM, Gianella S, Roan NR. PMID: 39798087.
View in:
PubMed Mentions: Fields:
-
A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions. Frontiers in Systems Biology. 2025 Jan 7; 4:1422384.
Sun SJ, Aikawa AM, Ashktorab AH, Beckmann BN, Enger EM, Espinosa EJ, Gai GX, Horne HB, Keim KP, Lasky-Su LJ, Letts LR, Maier MC, Mandal MM, Nichols NL, Roan RN, Russell RM, Rutter RJ, Saade SG, Sharma SK, Shiau SS, Thibodeau TS, Yang YS, Miele ML, Consortium CN. .
View in:
Publisher Site Mentions:
-
HIV-SEQ REVEALS GLOBAL HOST GENE EXPRESSION DIFFERENCES BETWEEN HIV-TRANSCRIBING CELLS FROM VIREMIC AND SUPPRESSED PEOPLE WITH HIV. bioRxiv. 2024 Dec 20.
Frouard J, Telwatte S, Luo X, Elphick N, Thomas R, Arneson D, Roychoudhury P, Butte AJ, Wong JK, Hoh R, Deeks SG, Lee SA, Roan NR, Yukl S. PMID: 39763963; PMCID: PMC11702770.
View in:
PubMed Mentions:
-
PP7.1-00174 Active HIV reservoir in jejunum exhibit distinct phenotypic features and evoke innate cell redistribution. Journal of Virus Eradication. 2024 Dec 1; 10:84.
Calvet-Mirabent CM, Yuan YM, Luo LX, Frouard FJ, Neidleman NJ, George GA, Tamaki TS, Chaillon CA, Hastie HE, Smith SD, Kieffer KC, Gianella GS, Roan RN. .
View in:
Publisher Site Mentions:
-
PP4.14 – 00024 HIV RNA+ cells from ART-suppressed PWH exhibit transcriptional profiles distinct from those during active viremia. Journal of Virus Eradication. 2024 Dec 1; 10:72.
Frouard FJ, Telwatte TS, Luo LX, Elphick EN, Thomas TR, Arneson AD, Roychoudhury RP, Butte BA, Wong WJ, Hoh HR, Deeks DS, Lee LS, Yukl YS, Roan RN. .
View in:
Publisher Site Mentions:
-
Transient anti-interferon autoantibodies in the airways are associated with recovery from COVID-19. Sci Transl Med. 2024 Nov 06; 16(772):eadq1789.
Babcock BR, Kosters A, Eddins DJ, Donaire MSB, Sarvadhavabhatla S, Pae V, Beltran F, Murray VW, Gill G, Xie G, Dobosh BS, Giacalone VD, Tirouvanziam RM, Ramonell RP, Jenks SA, Sanz I, Lee FE, Roan NR, Lee SA, Ghosn EEB. PMID: 39504354.
View in:
PubMed Mentions: Fields:
-
Silencing the transcriptionally active HIV reservoir to improve treatment outcomes. Nat Microbiol. 2024 Oct; 9(10):2470-2472.
Prigann J, Tavora R, Furler O'Brien RL, Schulze-Gahmen U, Boehm D, Roan NR, Nixon DF, Ndhlovu LC, Valente S, Ott M. PMID: 39289508.
View in:
PubMed Mentions:
1 Fields:
-
Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids. PNAS Nexus. 2024 Apr 29; pgae179.
Kong KW, Frouard FJ, Xie XG, Corley CM, Helmy HE, Zhang ZG, Schwarzer SR, Montano MM, Sohn SP, Roan RN, Ndhlovu NL, Gan GL, Greene GW. .
View in:
Publisher Site Mentions:
-
Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids. PNAS Nexus. 2024 May; 3(5):pgae179.
Kong W, Frouard J, Xie G, Corley MJ, Helmy E, Zhang G, Schwarzer R, Montano M, Sohn P, Roan NR, Ndhlovu LC, Gan L, Greene WC. PMID: 38737767; PMCID: PMC11086946.
View in:
PubMed Mentions:
4
-
Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection. Nat Commun. 2024 Apr 10; 15(1):3035.
Giron LB, Liu Q, Adeniji OS, Yin X, Kannan T, Ding J, Lu DY, Langan S, Zhang J, Azevedo JLLC, Li SH, Shalygin S, Azadi P, Hanna DB, Ofotokun I, Lazar J, Fischl MA, Haberlen S, Macatangay B, Adimora AA, Jamieson BD, Rinaldo C, Merenstein D, Roan NR, Kutsch O, Gange S, Wolinsky SM, Witt MD, Post WS, Kossenkov A, Landay AL, Frank I, Tien PC, Gross R, Brown TT, Abdel-Mohsen M. PMID: 38600088; PMCID: PMC11006954.
View in:
PubMed Mentions: Fields:
-
Systems analysis of innate and adaptive immunity in Long COVID. Semin Immunol. 2024 Mar; 72:101873.
Peluso MJ, Abdel-Mohsen M, Henrich TJ, Roan NR. PMID: 38460395.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCellsPHPublic Health
-
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2. Nat Immunol. 2024 Feb; 25(2):218-225.
Yin K, Peluso MJ, Luo X, Thomas R, Shin MG, Neidleman J, Andrew A, Young KC, Ma T, Hoh R, Anglin K, Huang B, Argueta U, Lopez M, Valdivieso D, Asare K, Deveau TM, Munter SE, Ibrahim R, Ständker L, Lu S, Goldberg SA, Lee SA, Lynch KL, Kelly JD, Martin JN, Münch J, Deeks SG, Henrich TJ, Roan NR. PMID: 38212464; PMCID: PMC10834368.
View in:
PubMed Mentions:
54 Fields:
Translation:
HumansCells
-
The hypoxia-regulated ectonucleotidase CD73 is a host determinant of HIV latency. Cell Rep. 2023 11 28; 42(11):113285.
Sperber HS, Raymond KA, Bouzidi MS, Ma T, Valdebenito S, Eugenin EA, Roan NR, Deeks SG, Winning S, Fandrey J, Schwarzer R, Pillai SK. PMID: 37910505; PMCID: PMC10838153.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
HIV-1 Remission: Accelerating the Path to Permanent HIV-1 Silencing. Viruses. 2023 Oct 28; 15(11):2171.
Lyons LD, Kumar KP, Roan RN, Defechereux DP, Feschotte FC, Lange LU, Murthy MN, Sameshima SP, Verdin VE, Ake AJ, Parsons PM, Nath NA, Gianella GS, Smith SD, Kallas KE, Villa VT, Strange SR, Mwesigwa MB, Furler O’Brien FR, Nixon ND, Ndhlovu NL, Valente VS, Ott OM. .
View in:
Publisher Site Mentions:
-
Advances in HIV Research Using Mass Cytometry. Curr HIV/AIDS Rep. 2023 04; 20(2):76-85.
George AF, Roan NR. PMID: 36689119; PMCID: PMC9869313.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons. mBio. 2022 12 20; 13(6):e0230822.
Kong W, Montano M, Corley MJ, Helmy E, Kobayashi H, Kinisu M, Suryawanshi R, Luo X, Royer LA, Roan NR, Ott M, Ndhlovu LC, Greene WC. PMID: 36314791; PMCID: PMC9765283.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansCells
-
CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir. mBio. 2022 10 26; 13(5):e0189122.
Packard TA, Schwarzer R, Herzig E, Rao D, Luo X, Egedal JH, Hsiao F, Widera M, Hultquist JF, Grimmett ZW, Messer RJ, Krogan NJ, Deeks SG, Roan NR, Dittmer U, Hasenkrug KJ, Greene WC. PMID: 36073812; PMCID: PMC9600577.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice. PLoS One. 2022; 17(8):e0273430.
Lee KS, Wong TY, Russ BP, Horspool AM, Miller OA, Rader NA, Givi JP, Winters MT, Wong ZYA, Cyphert HA, Denvir J, Stoilov P, Barbier M, Roan NR, Amin MS, Martinez I, Bevere JR, Damron FH. PMID: 36037222; PMCID: PMC9423646.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
-
Female Genital Fibroblasts Diminish the In Vitro Efficacy of PrEP against HIV. Viruses. 2022 08 04; 14(8).
George AF, McGregor M, Gingrich D, Neidleman J, Marquez RS, Young KC, Thanigaivelan KL, Greene WC, Tien PC, Deitchman AN, Spitzer TL, Roan NR. PMID: 36016345; PMCID: PMC9413545.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV. Elife. 2022 07 05; 11.
Ma T, McGregor M, Giron L, Xie G, George AF, Abdel-Mohsen M, Roan NR. PMID: 35787792; PMCID: PMC9255966.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Subsets of Tissue CD4 T Cells Display Different Susceptibilities to HIV Infection and Death: Analysis by CyTOF and Single Cell RNA-seq. Front Immunol. 2022; 13:883420.
Luo X, Frouard J, Zhang G, Neidleman J, Xie G, Sheedy E, Roan NR, Greene WC. PMID: 35784348; PMCID: PMC9245423.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination. Nature. 2022 07; 607(7918):351-355.
Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna JA, Ott M. PMID: 35584773; PMCID: PMC9279157.
-
Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood. BMC Med. 2022 04 15; 20(1):158.
Vallvé-Juanico J, George AF, Sen S, Thomas R, Shin MG, Kushnoor D, Vásquez JJ, Vo KC, Irwin JC, Roan NR, Combes AJ, Giudice LC. PMID: 35421980; PMCID: PMC9011995.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
-
Common and Divergent Features of T Cells from Blood, Gut, and Genital Tract of Antiretroviral Therapy-Treated HIV+ Women. J Immunol. 2022 04 01; 208(7):1790-1801.
Xie G, Moron-Lopez S, Siegel DA, Yin K, Polos A, Cohen J, Greenblatt RM, Tien PC, Lee SA, Yukl SA, Roan NR. PMID: 35296537; PMCID: PMC8976750.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
-
T-Cell Immune Dysregulation and Mortality in Women With Human Immunodeficiency Virus. J Infect Dis. 2022 02 15; 225(4):675-685.
Peters BA, Moon JY, Hanna DB, Kutsch O, Fischl M, Moran CA, Adimora AA, Gange S, Roan NR, Michel KG, Augenbraun M, Sharma A, Landay A, Desai S, Kaplan RC. PMID: 34448873; PMCID: PMC8844590.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
-
Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells From HIV+ Controllers and ART-Suppressed Individuals. Front Immunol. 2022; 13:803417.
George AF, Luo X, Neidleman J, Hoh R, Vohra P, Thomas R, Shin MG, Lee MJ, Blish CA, Deeks SG, Greene WC, Lee SA, Roan NR. PMID: 35154118; PMCID: PMC8829545.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Cell-Extrinsic Priming Increases Permissiveness of CD4+ T Cells to Human Immunodeficiency Virus Infection by Increasing C-C Chemokine Receptor Type 5 Co-receptor Expression and Cellular Activation Status. Front Microbiol. 2021; 12:763030.
Pedersen JG, Egedal JH, Packard TA, Thavachelvam K, Xie G, van der Sluis RM, Greene WC, Roan NR, Jakobsen MR. PMID: 34899645; PMCID: PMC8661899.
View in:
PubMed Mentions:
-
Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells. PLoS Pathog. 2021 11; 17(11):e1010034.
Adeniji OS, Kuri-Cervantes L, Yu C, Xu Z, Ho M, Chew GM, Shikuma C, Tomescu C, George AF, Roan NR, Ndhlovu LC, Liu Q, Muthumani K, Weiner DB, Betts MR, Xiao H, Abdel-Mohsen M. PMID: 34762717; PMCID: PMC8584986.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status. Elife. 2021 10 12; 10.
Neidleman J, Luo X, McGregor M, Xie G, Murray V, Greene WC, Lee SA, Roan NR. PMID: 34636722; PMCID: PMC8545397.
View in:
PubMed Mentions:
52 Fields:
Translation:
HumansCellsPHPublic Health
-
Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8+ T Cells during Convalescence. J Immunol. 2021 09 01; 207(5):1344-1356.
Ma T, Ryu H, McGregor M, Babcock B, Neidleman J, Xie G, George AF, Frouard J, Murray V, Gill G, Ghosn E, Newell EW, Lee SA, Roan NR. PMID: 34389625; PMCID: PMC8763019.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women. J Int AIDS Soc. 2021 07; 24(7):e25738.
Moron-Lopez S, Xie G, Kim P, Siegel DA, Lee S, Wong JK, Price JC, Elnachef N, Greenblatt RM, Tien PC, Roan NR, Yukl SA. PMID: 34235864; PMCID: PMC8264406.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Reliable Estimation of CD8 T Cell Inhibition of In Vitro HIV-1 Replication. Front Immunol. 2021; 12:666991.
Xu Y, Weideman AM, Abad-Fernandez M, Mollan KR, Kallon S, Samir S, Warren JA, Clutton G, Roan NR, Adimora AA, Archin N, Kuruc J, Gay C, Hudgens MG, Goonetilleke N. PMID: 34276657; PMCID: PMC8278574.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19. Cell Rep. 2021 07 20; 36(3):109414.
Neidleman J, Luo X, George AF, McGregor M, Yang J, Yun C, Murray V, Gill G, Greene WC, Vasquez J, Lee SA, Ghosn E, Lynch KL, Roan NR. PMID: 34260965; PMCID: PMC8238659.
View in:
PubMed Mentions:
55 Fields:
-
Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection. Mucosal Immunol. 2021 09; 14(5):1203-1213.
Egedal JH, Xie G, Packard TA, Laustsen A, Neidleman J, Georgiou K, Pillai SK, Greene WC, Jakobsen MR, Roan NR. PMID: 33976386; PMCID: PMC8379073.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4+ T cell subsets in vivo. Cell Rep. 2021 04 27; 35(4):109038.
Xie G, Luo X, Ma T, Frouard J, Neidleman J, Hoh R, Deeks SG, Greene WC, Roan NR. PMID: 33910003; PMCID: PMC8202093.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo. J Virol. 2021 03 25; 95(8).
Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC. PMID: 33536176; PMCID: PMC8103695.
View in:
PubMed Mentions:
9 Fields:
-
No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells. BMC Biol. 2021 01 20; 19(1):10.
McGinnis CS, Siegel DA, Xie G, Hartoularos G, Stone M, Ye CJ, Gartner ZJ, Roan NR, Lee SA. PMID: 33472616; PMCID: PMC7816397.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells. J Virol. 2020 12 22; 95(2).
Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S. PMID: 33115867; PMCID: PMC7944458.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
Impact of Biological Sex on Immune Activation and Frequency of the Latent HIV Reservoir During Suppressive Antiretroviral Therapy. J Infect Dis. 2020 11 09; 222(11):1843-1852.
Falcinelli SD, Shook-Sa BE, Dewey MG, Sridhar S, Read J, Kirchherr J, James KS, Allard B, Ghofrani S, Stuelke E, Baker C, Roan NR, Eron JJ, Kuruc JD, Ramirez C, Gay C, Mollan KR, Margolis DM, Adimora AA, Archin NM. PMID: 32496542; PMCID: PMC7653086.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
-
The HIV-1 latent reservoir is largely sensitive to circulating T cells. Elife. 2020 10 06; 9.
Warren JA, Zhou S, Xu Y, Moeser MJ, MacMillan DR, Council O, Kirchherr J, Sung JM, Roan NR, Adimora AA, Joseph S, Kuruc JD, Gay CL, Margolis DM, Archin N, Brumme ZL, Swanstrom R, Goonetilleke N. PMID: 33021198; PMCID: PMC7593086.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
-
Reproductive tract immune cells from pregnant women or those using depot medroxyprogesterone acetate show no excess susceptibility to HIV-1: Results of an ex vivo fusion assay. Contraception. 2021 01; 103(1):44-47.
Seidman D, Cavrois M, Hilton JF, Roan NR, Averbach S, Takeda M, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K. PMID: 33007299; PMCID: PMC7736211.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir. Elife. 2020 09 29; 9.
Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA, Palmer S, Greene WC, Roan NR. PMID: 32990219; PMCID: PMC7524554.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansCells
-
Sequence-independent recognition of the amyloid structural motif by GFP protein family. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22122-22127.
Xu SCS, LoRicco JG, Bishop AC, James NA, Huynh WH, McCallum SA, Roan NR, Makhatadze GI. PMID: 32839332; PMCID: PMC7486722.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential. Cell Rep Med. 2020 09 22; 1(6):100081.
Neidleman J, Luo X, Frouard J, Xie G, Gill G, Stein ES, McGregor M, Ma T, George AF, Kosters A, Greene WC, Vasquez J, Ghosn E, Lee S, Roan NR. PMID: 32839763; PMCID: PMC7437502.
View in:
PubMed Mentions:
133 Fields:
-
Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy. Cell Rep. 2020 08 04; 32(5):107991.
Colomb F, Giron LB, Kuri-Cervantes L, Adeniji OS, Ma T, Dweep H, Battivelli E, Verdin E, Palmer CS, Tateno H, Kossenkov AV, Roan NR, Betts MR, Abdel-Mohsen M. PMID: 32755584; PMCID: PMC7432956.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Seminal Plasma-Derived Extracellular-Vesicle Fractions from HIV-Infected Men Exhibit Unique MicroRNA Signatures and Induce a Proinflammatory Response in Cells Isolated from the Female Reproductive Tract. J Virol. 2020 07 30; 94(16).
Marques de Menezes EG, Jang K, George AF, Nyegaard M, Neidleman J, Inglis HC, Danesh A, Deng X, Afshari A, Kim YH, Billaud JN, Marson K, Pilcher CD, Pillai SK, Norris PJ, Roan NR. PMID: 32434889; PMCID: PMC7394899.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Loss of Preexisting Immunological Memory Among Human Immunodeficiency Virus-Infected Women Despite Immune Reconstitution With Antiretroviral Therapy. J Infect Dis. 2020 06 29; 222(2):243-251.
Thomas A, Hammarlund E, Gao L, Holman S, Michel KG, Glesby M, Villacres MC, Golub ET, Roan NR, French AL, Augenbraun MH, Slifka MK. PMID: 31867597; PMCID: PMC7323495.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread. Elife. 2020 05 26; 9.
Ma T, Luo X, George AF, Mukherjee G, Sen N, Spitzer TL, Giudice LC, Greene WC, Roan NR. PMID: 32452381; PMCID: PMC7250576.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
-
Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. PLoS Pathog. 2020 04; 16(4):e1008450.
Hsiao F, Frouard J, Gramatica A, Xie G, Telwatte S, Lee GQ, Roychoudhury P, Schwarzer R, Luo X, Yukl SA, Lee S, Hoh R, Deeks SG, Jones RB, Cavrois M, Greene WC, Roan NR. PMID: 32353080; PMCID: PMC7192375.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
-
Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling. Hum Reprod. 2020 03 27; 35(3):617-640.
George AF, Jang KS, Nyegaard M, Neidleman J, Spitzer TL, Xie G, Chen JC, Herzig E, Laustsen A, Marques de Menezes EG, Houshdaran S, Pilcher CD, Norris PJ, Jakobsen MR, Greene WC, Giudice LC, Roan NR. PMID: 32219408; PMCID: PMC7105328.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansCells
-
Measuring the contribution of γδ T cells to the persistent HIV reservoir. AIDS. 2020 03 01; 34(3):363-371.
James KS, Trumble I, Clohosey ML, Moeser M, Roan NR, Adimora AA, Joseph SB, Archin NM, Hudgens M, Soriano-Sarabia N. PMID: 31764074; PMCID: PMC6994336.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansCells
-
Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo. PLoS One. 2019; 14(8):e0221181.
Cavrois M, Hilton JF, Roan NR, Takeda M, Seidman D, Averbach S, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K. PMID: 31437197; PMCID: PMC6705759.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
Single-cell Motility Analysis of Tethered Human Spermatozoa. Bio Protoc. 2019 Mar 05; 9(5).
Skinner WM, Mannowetz N, Lishko PV, Roan NR. PMID: 31032381; PMCID: PMC6482966.
View in:
PubMed Mentions:
3
-
Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function. Nat Commun. 2018 08 30; 9(1):3525.
Laustsen A, Bak RO, Krapp C, Kjær L, Egedahl JH, Petersen CC, Pillai S, Tang HQ, Uldbjerg N, Porteus M, Roan NR, Nyegaard M, Denton PW, Jakobsen MR. PMID: 30166549; PMCID: PMC6117296.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansCells
-
Potent and rapid activation of tropomyosin-receptor kinase A in endometrial stromal fibroblasts by seminal plasma. Biol Reprod. 2018 08 01; 99(2):336-348.
Martin JW, Chen JC, Neidleman J, Tatsumi K, Hu J, Giudice LC, Greene WC, Roan NR. PMID: 29518187; PMCID: PMC6084595.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
Structure, function and antagonism of semen amyloids. Chem Commun (Camb). 2018 Jul 05; 54(55):7557-7569.
Röcker A, Roan NR, Yadav JK, Fändrich M, Münch J. PMID: 29873340; PMCID: PMC6033663.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
-
Semen inhibits Zika virus infection of cells and tissues from the anogenital region. Nat Commun. 2018 06 07; 9(1):2207.
Müller JA, Harms M, Krüger F, Groß R, Joas S, Hayn M, Dietz AN, Lippold S, von Einem J, Schubert A, Michel M, Mayer B, Cortese M, Jang KS, Sandi-Monroy N, Deniz M, Ebner F, Vapalahti O, Otto M, Bartenschlager R, Herbeuval JP, Schmidt-Chanasit J, Roan NR, Münch J. PMID: 29880824; PMCID: PMC5992203.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
-
Resident T cells stand up to HIV. Sci Immunol. 2018 06 01; 3(24).
Roan NR. PMID: 29858287.
View in:
PubMed Mentions: Fields:
Translation:
HumansCells
-
An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S31-S39.
Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S. PMID: 28882052; PMCID: PMC5684666.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
-
Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017 07 25; 20(4):984-998.
Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR. PMID: 28746881; PMCID: PMC5560086.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansCells
-
Semen amyloids participate in spermatozoa selection and clearance. Elife. 2017 06 27; 6.
Roan NR, Sandi-Monroy N, Kohgadai N, Usmani SM, Hamil KG, Neidleman J, Montano M, Ständker L, Röcker A, Cavrois M, Rosen J, Marson K, Smith JF, Pilcher CD, Gagsteiger F, Sakk O, O'Rand M, Lishko PV, Kirchhoff F, Münch J, Greene WC. PMID: 28653619; PMCID: PMC5487211.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansCells
-
Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 2017 02; 13(2):e1006163.
Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR. PMID: 28207890; PMCID: PMC5312882.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansCells
-
Comparison of the effect of semen from HIV-infected and uninfected men on CD4+ T-cell infection. AIDS. 2016 05 15; 30(8):1197-208.
Camus C, Matusali G, Bourry O, Mahe D, Aubry F, Bujan L, Pasquier C, Massip P, Ravel C, Zirafi O, Munch J, Roan NR, Pineau C, Dejucq-Rainsford N. PMID: 26854806; PMCID: PMC4856179.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Gallic Acid Is an Antagonist of Semen Amyloid Fibrils That Enhance HIV-1 Infection. J Biol Chem. 2016 Jul 01; 291(27):14045-14055.
LoRicco JG, Xu CS, Neidleman J, Bergkvist M, Greene WC, Roan NR, Makhatadze GI. PMID: 27226574; PMCID: PMC4933164.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
Amyloid formation: functional friend or fearful foe? J Intern Med. 2016 Aug; 280(2):139-52.
Bergman P, Roan NR, Römling U, Bevins CL, Münch J. PMID: 27151743; PMCID: PMC4956559.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
-
Evaluation of EPI-X4 as a urinary peptide biomarker for diagnosis and prognosis of late acute GvHD. Bone Marrow Transplant. 2016 08; 51(8):1137-9.
Müller JA, Zirafi O, Roan NR, Lee SJ, Münch J. PMID: 27042833; PMCID: PMC4972659.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract. Curr HIV/AIDS Rep. 2016 Feb; 13(1):53-63.
Roan NR, Jakobsen MR. PMID: 26879654; PMCID: PMC5408509.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCells
-
Isolation and Culture of Human Endometrial Epithelial Cells and Stromal Fibroblasts. Bio Protoc. 2015 Oct 20; 5(20).
Chen JC, Roan NR. PMID: 27347495; PMCID: PMC4918807.
View in:
PubMed Mentions:
13
-
Improving preclinical models of HIV microbicide efficacy. Trends Microbiol. 2015 Aug; 23(8):445-7.
Roan NR, Münch J. PMID: 26250616; PMCID: PMC4818646.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsPHPublic Health
-
Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides. Sci Transl Med. 2014 Nov 12; 6(262):262ra157.
Zirafi O, Kim KA, Roan NR, Kluge SF, Müller JA, Jiang S, Mayer B, Greene WC, Kirchhoff F, Münch J. PMID: 25391483; PMCID: PMC4372245.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansCells
-
Structural characterization of semen coagulum-derived SEM1(86-107) amyloid fibrils that enhance HIV-1 infection. Biochemistry. 2014 May 27; 53(20):3267-77.
French KC, Roan NR, Makhatadze GI. PMID: 24811874; PMCID: PMC4039337.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
-
Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection. J Virol. 2014 Jul; 88(13):7221-34.
Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, Münch J, Witkowska HE, Greene WC. PMID: 24741080; PMCID: PMC4054457.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansCells
-
Interaction of fibronectin with semen amyloids synergistically enhances HIV infection. J Infect Dis. 2014 Oct 01; 210(7):1062-6.
Roan NR, Chu S, Liu H, Neidleman J, Witkowska HE, Greene WC. PMID: 24719472; PMCID: PMC4168303.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nat Commun. 2014 Apr 01; 5:3508.
Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher CD, Gagsteiger F, Fändrich M, Kirchhoff F, Münch J. PMID: 24691351; PMCID: PMC4129123.
View in:
PubMed Mentions:
55 Fields:
Translation:
HumansCells
-
Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts. Hum Reprod. 2014 Jun; 29(6):1255-70.
Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, Kohgadai N, Irwin JC, Greene WC, Giudice LC, Roan NR. PMID: 24626806; PMCID: PMC4017943.
View in:
PubMed Mentions:
34 Fields:
Translation:
HumansCells
-
Seminal plasma and semen amyloids enhance cytomegalovirus infection in cell culture. J Virol. 2013 Dec; 87(23):12583-91.
Tang Q, Roan NR, Yamamura Y. PMID: 24027327; PMCID: PMC3838150.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
-
Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses. Nat Nanotechnol. 2013 Feb; 8(2):130-6.
Yolamanova M, Meier C, Shaytan AK, Vas V, Bertoncini CW, Arnold F, Zirafi O, Usmani SM, Müller JA, Sauter D, Goffinet C, Palesch D, Walther P, Roan NR, Geiger H, Lunov O, Simmet T, Bohne J, Schrezenmeier H, Schwarz K, Ständker L, Forssmann WG, Salvatella X, Khalatur PG, Khokhlov AR, Knowles TP, Weil T, Kirchhoff F, Münch J. PMID: 23334171.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
-
[Role of semen-derived amyloid fibrils as facilitators of HIV infection]. Med Sci (Paris). 2012 Apr; 28(4):358-60.
Roan NR, Cavrois M, Greene WC. PMID: 22549858.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection. Cell Host Microbe. 2011 Dec 15; 10(6):541-50.
Roan NR, Müller JA, Liu H, Chu S, Arnold F, Stürzel CM, Walther P, Dong M, Witkowska HE, Kirchhoff F, Münch J, Greene WC. PMID: 22177559; PMCID: PMC3257029.
View in:
PubMed Mentions:
93 Fields:
Translation:
HumansCells
-
Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection. J Virol. 2012 Jan; 86(2):1244-9.
Arnold F, Schnell J, Zirafi O, Stürzel C, Meier C, Weil T, Ständker L, Forssmann WG, Roan NR, Greene WC, Kirchhoff F, Münch J. PMID: 22090109; PMCID: PMC3255800.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansCells
-
Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI. Retrovirology. 2010 Jun 23; 7:55.
Kim KA, Yolamanova M, Zirafi O, Roan NR, Staendker L, Forssmann WG, Burgener A, Dejucq-Rainsford N, Hahn BH, Shaw GM, Greene WC, Kirchhoff F, Münch J. PMID: 20573198; PMCID: PMC2914040.
View in:
PubMed Mentions:
81 Fields:
Translation:
HumansAnimalsCells
-
Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection). J Biol Chem. 2010 Jan 15; 285(3):1861-9.
Roan NR, Sowinski S, Münch J, Kirchhoff F, Greene WC. PMID: 19897482; PMCID: PMC2804344.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
-
T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis. J Immunol. 2009 Jul 15; 183(2):1313-9.
Gondek DC, Roan NR, Starnbach MN. PMID: 19561106; PMCID: PMC2723820.
View in:
PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
-
The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J Virol. 2009 Jan; 83(1):73-80.
Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC. PMID: 18945786; PMCID: PMC2612336.
View in:
PubMed Mentions:
105 Fields:
Translation:
HumansCells
-
Conquering sexually transmitted diseases. Nat Rev Immunol. 2008 Apr; 8(4):313-7.
Starnbach MN, Roan NR. PMID: 18309315.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansPHPublic Health
-
Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3831-6.
Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang JH, Bell GW, Starnbach MN, Ploegh HL. PMID: 18245382; PMCID: PMC2268777.
View in:
PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
-
A seminal finding for understanding HIV transmission. Cell. 2007 Dec 14; 131(6):1044-6.
Roan NR, Greene WC. PMID: 18083095.
View in:
PubMed Mentions:
13 Fields:
Translation:
Humans
-
Immune-mediated control of Chlamydia infection. Cell Microbiol. 2008 Jan; 10(1):9-19.
Roan NR, Starnbach MN. PMID: 17979983.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansCells
-
Antigen-specific CD8+ T cells respond to Chlamydia trachomatis in the genital mucosa. J Immunol. 2006 Dec 01; 177(11):7974-9.
Roan NR, Starnbach MN. PMID: 17114470.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells
-
Monitoring the T cell response to genital tract infection. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12069-74.
Roan NR, Gierahn TM, Higgins DE, Starnbach MN. PMID: 16880389; PMCID: PMC1567698.
View in:
PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
-
Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen. J Infect Dis. 2006 May 15; 193(10):1459-63.
Balsara ZR, Roan NR, Steele LN, Starnbach MN. PMID: 16619195.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Spt10-dependent transcriptional activation in Saccharomyces cerevisiae requires both the Spt10 acetyltransferase domain and Spt21. Mol Cell Biol. 2004 Jan; 24(1):135-43.
Hess D, Liu B, Roan NR, Sternglanz R, Winston F. PMID: 14673149; PMCID: PMC303362.
View in:
PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
-
The Listeria monocytogenes lemA gene product is not required for intracellular infection or to activate fMIGWII-specific T cells. Infect Immun. 2003 Dec; 71(12):6721-7.
D'Orazio SE, Velasquez M, Roan NR, Naveiras-Torres O, Starnbach MN. PMID: 14638756; PMCID: PMC308916.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells