Nadia Roan, PhD

Title(s)Professor, Urology
SchoolSchool of Medicine
Address35 Medical Center Way
San Francisco CA 94143
Phone415-734-4883
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, CA05/2021Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    NIH2022  - 2027R01DK131526. PI: Roan
    NIH2022  - 2024R21AI172060. PI: Roan
    NIH2022  - 2024R21AI170166. PI: Roan
    NIH2017  - 2022P01AI131374. PI of P01: Greene, PI of Project 1: Roan
    NIH2022  - 2027P01AI69606. PI: Smith
    NIH2021  - 2026CARE Collaboratory. PI: Margolis
    NIH2021  - 2026HOPE Collaboratory. PI: Ott
    NIH2021  - 2022R01AI147777 Supplement
    Program for Breakthrough Biomedical Research2020  - 2021PBBR COVID-19 Grant. PI: Roan
    Fast Grants2020  - 2020Fast Grants for COVID-19 Research. PI: Roan
    NIH2019  - 2023R01AI147777. PI: Roan
    NIH2016  - 2021R01AI127219. PI: Roan
    NIH2016  - 2018R21AI122821. PI: Roan
    NIH2015  - 2017R21AI116252. PI: Roan
    NIH2022  - 2027P01AI69606. PI of P01: Yukl, PI of Project 3: Roan
    NIH2018  - 2023R01AI141003. PI: Henrich
    NIH2017  - 2020R15GM123447. PI: Jensen-Seaman
    amfAR2016  - 2021amfAR Cure Institute
    UCSF, NIH2016  - 2017NCTRI P50 Pilot Grant Award. PI: Roan
    NIH2016  - 2017WIHS W16036 PI: Yukl
    CFAR2014  - 2015Center for AIDS Research Basic Science HIV/AIDS grant
    NIH2013  - 2016K99/R00 (K99AI103262, R00AI104262). PI: Roan
    UCSF2013  - 2015Hellman Award for Early-Career Faculty
    NIH2012  - 2013KURe K12
    NIH2012  - 2017R01HD074511. PI: Pilcher
    CFAR2012Centers for AIDS Research Early Career Award of Excellence in Basic Research
    The J. David Gladstones Institutes2012Gladstone Institute of Virology and Immunology Award for Scientific Excellence
    A.P. Giannini Foundation2008  - 2010A.P. Giannini Foundation Postdoctoral Fellowship
    NIH2006Travel Award for the 11th International Symposium on Human Chlamydial Infections
    Harvard Medical School2004Manfred Karnovsky Fellowship Award
    U.C. Berkeley2001Outstanding Scholar Award
    NSF2001  - 2004National Science Foundation Pre-Doctoral Fellowship
    U.C. Berkeley2001F.H. Carpenter Memorial Price in Biochemistry
    U.C. Berkeley2001University Medal Finalist

    Collapse Overview 
    Collapse Overview
    The Roan Lab studies how intracellular and extracellular factors in the tissue microenvironment can affect infection by HIV, mucosal immunity, and reproductive health. We have demonstrated that genital and rectal fibroblasts, amongst the most abundant cells of the mucosa, potently increase HIV infection of T cells through at least two distinct mechanisms: promoting viral entry, and altering the cellular state of T cells to render them more permissive to viral replication. To characterize the molecular basis of how intrinsic and extrinsic perturbations can render some subsets of CD4+ T cells more susceptible than others to HIV infection, we are using a variety of global gene expression analysis approaches, including CyTOF and RNA-seq. These approaches are also being used to characterize the HIV latent reservoir and the nature of viral rebound upon antiretroviral treatment interruption. Another research interest in the lab is to understand how factors in seminal plasma affect reproductive health and susceptibility to sexually transmitted diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Multiomics characterization, induction, and elimination of the HIV gut reservoir
    NIH R01DK131526Jul 1, 2022 - Jun 30, 2027
    Role: Principal Investigator
    Characterizing ART-free NK cell-mediated control of HIV infection in people living with HIV
    NIH R21AI172060Jul 1, 2022 - Jun 30, 2024
    Role: Principal Investigator
    Single-cell analysis of glycomic and proteomic features of the HIV reservoir
    NIH R21AI170166Jul 1, 2022 - Jun 30, 2022
    Role: Principal Investigator
    Reservoir features associated with time-to-rebound during analytical treatment interruption
    NIH P01AI69606May 1, 2022 - Apr 30, 2027
    Role: Principal Investigator
    Leaving, Coming, and Staying HIV Obligate Microenvironments (HOME)
    NIH P01AI169609Apr 1, 2022 - Mar 31, 2027
    Role: Co-Investigator
    Phenotypic and mechanistic analysis of the in vivo HIV latent reservoir by single-cell technologies
    NIH R01AI147777Aug 1, 2019 - Jul 31, 2023
    Role: Principal Investigator
    SF Bay Area MACS/WIHS Combined Cohort Study
    NIH U01HL146242Apr 1, 2019 - Mar 31, 2026
    Role: Co-Investigator
    Targeting Non Viral Markers of HIV Persistence
    NIH R01AI141003May 15, 2018 - Apr 30, 2023
    Role: Co-Investigator
    Exploiting the Host-HIV Interface To Identify Biomarkers Predicting Time to Viral Rebound after Treatment Interruption
    NIH P01AI131374Aug 8, 2017 - Jul 31, 2022
    Role: Principal Investigator of Project 1
    Elucidating the mechanism of progesterone-induced permissivity in the upper female reproductive tract
    NIH R01AI127219Sep 26, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Characterization of Exosomes From Semen of Uninfected and HIV-Infected Men
    NIH R21AI122821Mar 1, 2016 - Feb 28, 2019
    Role: Principal Investigator
    Characterization of Gallic Acid as a Novel HIV Microbicide Candidate
    NIH R21AI116252Jul 1, 2015 - Jun 30, 2019
    Role: Principal Investigator
    Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization
    NIH R00AI104262May 15, 2013 - Nov 30, 2016
    Role: Principal Investigator
    Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization
    NIH K99AI104262May 15, 2013 - Apr 30, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CCL2: a Chemokine Potentially Promoting Early Seeding of the Latent HIV Reservoir. mBio. 2022 Sep 08; e0189122. Packard TA, Schwarzer R, Herzig E, Rao D, Luo X, Egedal JH, Hsiao F, Widera M, Hultquist JF, Grimmett ZW, Messer RJ, Krogan NJ, Deeks SG, Roan NR, Dittmer U, Hasenkrug KJ, Greene WC. PMID: 36073812.
      View in: PubMed   Mentions:
    2. SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice. PLoS One. 2022; 17(8):e0273430. Lee KS, Wong TY, Russ BP, Horspool AM, Miller OA, Rader NA, Givi JP, Winters MT, Wong ZYA, Cyphert HA, Denvir J, Stoilov P, Barbier M, Roan NR, Amin MS, Martinez I, Bevere JR, Damron FH. PMID: 36037222.
      View in: PubMed   Mentions:
    3. Female Genital Fibroblasts Diminish the In Vitro Efficacy of PrEP against HIV. Viruses. 2022 Aug 04; 14(8). George AF, McGregor M, Gingrich D, Neidleman J, Marquez RS, Young KC, Thanigaivelan KL, Greene WC, Tien PC, Deitchman AN, Spitzer TL, Roan NR. PMID: 36016345; PMCID: PMC9413545.
      View in: PubMed   Mentions:
    4. Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV. Elife. 2022 07 05; 11. Ma T, McGregor M, Giron L, Xie G, George AF, Abdel-Mohsen M, Roan NR. PMID: 35787792; PMCID: PMC9255966.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Subsets of Tissue CD4 T Cells Display Different Susceptibilities to HIV Infection and Death: Analysis by CyTOF and Single Cell RNA-seq. Front Immunol. 2022; 13:883420. Luo X, Frouard J, Zhang G, Neidleman J, Xie G, Sheedy E, Roan NR, Greene WC. PMID: 35784348; PMCID: PMC9245423.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination. Nature. 2022 07; 607(7918):351-355. Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, Garcia-Knight MA, Sotomayor-Gonzalez A, Servellita V, Gliwa A, Nguyen J, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Soveg FW, George AF, Fang X, Maishan M, Matthay M, Morris MK, Wadford D, Hanson C, Greene WC, Andino R, Spraggon L, Roan NR, Chiu CY, Doudna JA, Ott M. PMID: 35584773; PMCID: PMC9279157.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    7. Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood. BMC Med. 2022 04 15; 20(1):158. Vallvé-Juanico J, George AF, Sen S, Thomas R, Shin MG, Kushnoor D, Vásquez JJ, Vo KC, Irwin JC, Roan NR, Combes AJ, Giudice LC. PMID: 35421980; PMCID: PMC9011995.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Common and Divergent Features of T Cells from Blood, Gut, and Genital Tract of Antiretroviral Therapy-Treated HIV+ Women. J Immunol. 2022 04 01; 208(7):1790-1801. Xie G, Moron-Lopez S, Siegel DA, Yin K, Polos A, Cohen J, Greenblatt RM, Tien PC, Lee SA, Yukl SA, Roan NR. PMID: 35296537; PMCID: PMC8976750.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. T-Cell Immune Dysregulation and Mortality in Women With Human Immunodeficiency Virus. J Infect Dis. 2022 02 15; 225(4):675-685. Peters BA, Moon JY, Hanna DB, Kutsch O, Fischl M, Moran CA, Adimora AA, Gange S, Roan NR, Michel KG, Augenbraun M, Sharma A, Landay A, Desai S, Kaplan RC. PMID: 34448873; PMCID: PMC8844590.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells From HIV+ Controllers and ART-Suppressed Individuals. Front Immunol. 2022; 13:803417. George AF, Luo X, Neidleman J, Hoh R, Vohra P, Thomas R, Shin MG, Lee MJ, Blish CA, Deeks SG, Greene WC, Lee SA, Roan NR. PMID: 35154118; PMCID: PMC8829545.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Cell-Extrinsic Priming Increases Permissiveness of CD4+ T Cells to Human Immunodeficiency Virus Infection by Increasing C-C Chemokine Receptor Type 5 Co-receptor Expression and Cellular Activation Status. Front Microbiol. 2021; 12:763030. Pedersen JG, Egedal JH, Packard TA, Thavachelvam K, Xie G, van der Sluis RM, Greene WC, Roan NR, Jakobsen MR. PMID: 34899645; PMCID: PMC8661899.
      View in: PubMed   Mentions:
    12. Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells. PLoS Pathog. 2021 11; 17(11):e1010034. Adeniji OS, Kuri-Cervantes L, Yu C, Xu Z, Ho M, Chew GM, Shikuma C, Tomescu C, George AF, Roan NR, Ndhlovu LC, Liu Q, Muthumani K, Weiner DB, Betts MR, Xiao H, Abdel-Mohsen M. PMID: 34762717; PMCID: PMC8584986.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status. Elife. 2021 10 12; 10. Neidleman J, Luo X, McGregor M, Xie G, Murray V, Greene WC, Lee SA, Roan NR. PMID: 34636722; PMCID: PMC8545397.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCellsPHPublic Health
    14. Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8+ T Cells during Convalescence. J Immunol. 2021 09 01; 207(5):1344-1356. Ma T, Ryu H, McGregor M, Babcock B, Neidleman J, Xie G, George AF, Frouard J, Murray V, Gill G, Ghosn E, Newell EW, Lee SA, Roan NR. PMID: 34389625; PMCID: PMC8763019.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. Tissue-specific differences in HIV DNA levels and mechanisms that govern HIV transcription in blood, gut, genital tract and liver in ART-treated women. J Int AIDS Soc. 2021 07; 24(7):e25738. Moron-Lopez S, Xie G, Kim P, Siegel DA, Lee S, Wong JK, Price JC, Elnachef N, Greenblatt RM, Tien PC, Roan NR, Yukl SA. PMID: 34235864; PMCID: PMC8264406.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Reliable Estimation of CD8 T Cell Inhibition of In Vitro HIV-1 Replication. Front Immunol. 2021; 12:666991. Xu Y, Weideman AM, Abad-Fernandez M, Mollan KR, Kallon S, Samir S, Warren JA, Clutton G, Roan N, Adimora AA, Archin N, Kuruc J, Gay C, Hudgens MG, Goonetilleke N. PMID: 34276657; PMCID: PMC8278574.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19. Cell Rep. 2021 07 20; 36(3):109414. Neidleman J, Luo X, George AF, McGregor M, Yang J, Yun C, Murray V, Gill G, Greene WC, Vasquez J, Lee SA, Ghosn E, Lynch KL, Roan NR. PMID: 34260965; PMCID: PMC8238659.
      View in: PubMed   Mentions: 20     Fields:    
    18. Hyaluronic acid is a negative regulator of mucosal fibroblast-mediated enhancement of HIV infection. Mucosal Immunol. 2021 09; 14(5):1203-1213. Egedal JH, Xie G, Packard TA, Laustsen A, Neidleman J, Georgiou K, Pillai SK, Greene WC, Jakobsen MR, Roan NR. PMID: 33976386; PMCID: PMC8379073.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4+ T cell subsets in vivo. Cell Rep. 2021 04 27; 35(4):109038. Xie G, Luo X, Ma T, Frouard J, Neidleman J, Hoh R, Deeks SG, Greene WC, Roan NR. PMID: 33910003; PMCID: PMC8202093.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. Evaluating a New Class of AKT/mTOR Activators for HIV Latency Reversing Activity Ex Vivo and In Vivo. J Virol. 2021 Feb 03. Gramatica A, Schwarzer R, Brantley W, Varco-Merth B, Sperber HS, Hull PA, Montano M, Migueles SA, Rosenthal D, Hogan LE, Johnson JR, Packard TA, Grimmett ZW, Herzig E, Besnard E, Nekorchuk M, Hsiao F, Deeks SG, Snape M, Kiernan B, Roan NR, Lifson JD, Estes JD, Picker LJ, Verdin E, Krogan NJ, Henrich TJ, Connors M, Ott M, Pillai SK, Okoye AA, Greene WC. PMID: 33536176; PMCID: PMC8103695.
      View in: PubMed   Mentions: 5     Fields:    
    21. No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells. BMC Biol. 2021 01 20; 19(1):10. McGinnis CS, Siegel DA, Xie G, Hartoularos G, Stone M, Ye CJ, Gartner ZJ, Roan NR, Lee SA. PMID: 33472616; PMCID: PMC7816397.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    22. Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103+ and Gut CD4+ T Cells. J Virol. 2020 12 22; 95(2). Yukl SA, Khan S, Chen TH, Trapecar M, Wu F, Xie G, Telwatte S, Fulop D, Pico AR, Laird GM, Ritter KD, Jones NG, Lu CM, Siliciano RF, Roan NR, Milush JM, Somsouk M, Deeks SG, Hunt PW, Sanjabi S. PMID: 33115867; PMCID: PMC7944458.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    23. Impact of Biological Sex on Immune Activation and Frequency of the Latent HIV Reservoir During Suppressive Antiretroviral Therapy. J Infect Dis. 2020 11 09; 222(11):1843-1852. Falcinelli SD, Shook-Sa BE, Dewey MG, Sridhar S, Read J, Kirchherr J, James KS, Allard B, Ghofrani S, Stuelke E, Baker C, Roan NR, Eron JJ, Kuruc JD, Ramirez C, Gay C, Mollan KR, Margolis DM, Adimora AA, Archin NM. PMID: 32496542; PMCID: PMC7653086.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    24. The HIV-1 latent reservoir is largely sensitive to circulating T cells. Elife. 2020 10 06; 9. Warren JA, Zhou S, Xu Y, Moeser MJ, MacMillan DR, Council O, Kirchherr J, Sung JM, Roan NR, Adimora AA, Joseph S, Kuruc JD, Gay CL, Margolis DM, Archin N, Brumme ZL, Swanstrom R, Goonetilleke N. PMID: 33021198; PMCID: PMC7593086.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    25. Reproductive tract immune cells from pregnant women or those using depot medroxyprogesterone acetate show no excess susceptibility to HIV-1: Results of an ex vivo fusion assay. Contraception. 2021 01; 103(1):44-47. Seidman D, Cavrois M, Hilton JF, Roan NR, Averbach S, Takeda M, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K. PMID: 33007299; PMCID: PMC7736211.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir. Elife. 2020 09 29; 9. Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA, Palmer S, Greene WC, Roan NR. PMID: 32990219; PMCID: PMC7524554.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    27. Sequence-independent recognition of the amyloid structural motif by GFP protein family. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22122-22127. Xu SCS, LoRicco JG, Bishop AC, James NA, Huynh WH, McCallum SA, Roan NR, Makhatadze GI. PMID: 32839332; PMCID: PMC7486722.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. SARS-CoV-2-Specific T Cells Exhibit Phenotypic Features of Helper Function, Lack of Terminal Differentiation, and High Proliferation Potential. Cell Rep Med. 2020 09 22; 1(6):100081. Neidleman J, Luo X, Frouard J, Xie G, Gill G, Stein ES, McGregor M, Ma T, George AF, Kosters A, Greene WC, Vasquez J, Ghosn E, Lee S, Roan NR. PMID: 32839763; PMCID: PMC7437502.
      View in: PubMed   Mentions: 80     Fields:    
    29. Sialyl-LewisX Glycoantigen Is Enriched on Cells with Persistent HIV Transcription during Therapy. Cell Rep. 2020 08 04; 32(5):107991. Colomb F, Giron LB, Kuri-Cervantes L, Adeniji OS, Ma T, Dweep H, Battivelli E, Verdin E, Palmer CS, Tateno H, Kossenkov AV, Roan NR, Betts MR, Abdel-Mohsen M. PMID: 32755584; PMCID: PMC7432956.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    30. Seminal Plasma-Derived Extracellular-Vesicle Fractions from HIV-Infected Men Exhibit Unique MicroRNA Signatures and Induce a Proinflammatory Response in Cells Isolated from the Female Reproductive Tract. J Virol. 2020 07 30; 94(16). Marques de Menezes EG, Jang K, George AF, Nyegaard M, Neidleman J, Inglis HC, Danesh A, Deng X, Afshari A, Kim YH, Billaud JN, Marson K, Pilcher CD, Pillai SK, Norris PJ, Roan NR. PMID: 32434889; PMCID: PMC7394899.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    31. Loss of Preexisting Immunological Memory Among Human Immunodeficiency Virus-Infected Women Despite Immune Reconstitution With Antiretroviral Therapy. J Infect Dis. 2020 06 29; 222(2):243-251. Thomas A, Hammarlund E, Gao L, Holman S, Michel KG, Glesby M, Villacres MC, Golub ET, Roan NR, French AL, Augenbraun MH, Slifka MK. PMID: 31867597; PMCID: PMC7323495.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    32. HIV efficiently infects T cells from the endometrium and remodels them to promote systemic viral spread. Elife. 2020 05 26; 9. Ma T, Luo X, George AF, Mukherjee G, Sen N, Spitzer TL, Giudice LC, Greene WC, Roan NR. PMID: 32452381; PMCID: PMC7250576.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    33. Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. PLoS Pathog. 2020 04; 16(4):e1008450. Hsiao F, Frouard J, Gramatica A, Xie G, Telwatte S, Lee GQ, Roychoudhury P, Schwarzer R, Luo X, Yukl SA, Lee S, Hoh R, Deeks SG, Jones RB, Cavrois M, Greene WC, Roan NR. PMID: 32353080; PMCID: PMC7192375.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    34. Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling. Hum Reprod. 2020 03 27; 35(3):617-640. George AF, Jang KS, Nyegaard M, Neidleman J, Spitzer TL, Xie G, Chen JC, Herzig E, Laustsen A, Marques de Menezes EG, Houshdaran S, Pilcher CD, Norris PJ, Jakobsen MR, Greene WC, Giudice LC, Roan NR. PMID: 32219408; PMCID: PMC7105328.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    35. Measuring the contribution of γδ T cells to the persistent HIV reservoir. AIDS. 2020 03 01; 34(3):363-371. James KS, Trumble I, Clohosey ML, Moeser M, Roan NR, Adimora AA, Joseph SB, Archin NM, Hudgens M, Soriano-Sarabia N. PMID: 31764074; PMCID: PMC6994336.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    36. Effects of the levonorgestrel-containing intrauterine device, copper intrauterine device, and levonorgestrel-containing oral contraceptive on susceptibility of immune cells from cervix, endometrium and blood to HIV-1 fusion measured ex vivo. PLoS One. 2019; 14(8):e0221181. Cavrois M, Hilton JF, Roan NR, Takeda M, Seidman D, Averbach S, Chang E, Raman N, Greenblatt R, Shacklett BL, Smith-McCune K. PMID: 31437197; PMCID: PMC6705759.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    37. Single-cell Motility Analysis of Tethered Human Spermatozoa. Bio Protoc. 2019 Mar 05; 9(5). Skinner WM, Mannowetz N, Lishko PV, Roan NR. PMID: 31032381; PMCID: PMC6482966.
      View in: PubMed   Mentions:
    38. Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function. Nat Commun. 2018 08 30; 9(1):3525. Laustsen A, Bak RO, Krapp C, Kjær L, Egedahl JH, Petersen CC, Pillai S, Tang HQ, Uldbjerg N, Porteus M, Roan NR, Nyegaard M, Denton PW, Jakobsen MR. PMID: 30166549; PMCID: PMC6117296.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    39. Potent and rapid activation of tropomyosin-receptor kinase A in endometrial stromal fibroblasts by seminal plasma. Biol Reprod. 2018 08 01; 99(2):336-348. Martin JW, Chen JC, Neidleman J, Tatsumi K, Hu J, Giudice LC, Greene WC, Roan NR. PMID: 29518187; PMCID: PMC6084595.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    40. Structure, function and antagonism of semen amyloids. Chem Commun (Camb). 2018 Jul 05; 54(55):7557-7569. Röcker A, Roan NR, Yadav JK, Fändrich M, Münch J. PMID: 29873340; PMCID: PMC6033663.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    41. Semen inhibits Zika virus infection of cells and tissues from the anogenital region. Nat Commun. 2018 06 07; 9(1):2207. Müller JA, Harms M, Krüger F, Groß R, Joas S, Hayn M, Dietz AN, Lippold S, von Einem J, Schubert A, Michel M, Mayer B, Cortese M, Jang KS, Sandi-Monroy N, Deniz M, Ebner F, Vapalahti O, Otto M, Bartenschlager R, Herbeuval JP, Schmidt-Chanasit J, Roan NR, Münch J. PMID: 29880824; PMCID: PMC5992203.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    42. Resident T cells stand up to HIV. Sci Immunol. 2018 06 01; 3(24). Roan NR. PMID: 29858287.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    43. An Optimized and Validated Method for Isolation and Characterization of Lymphocytes from HIV+ Human Gut Biopsies. AIDS Res Hum Retroviruses. 2017 Nov; 33(S1):S31-S39. Trapecar M, Khan S, Roan NR, Chen TH, Telwatte S, Deswal M, Pao M, Somsouk M, Deeks SG, Hunt PW, Yukl S, Sanjabi S. PMID: 28882052; PMCID: PMC5684666.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    44. Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017 07 25; 20(4):984-998. Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR. PMID: 28746881; PMCID: PMC5560086.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    45. Semen amyloids participate in spermatozoa selection and clearance. Elife. 2017 06 27; 6. Roan NR, Sandi-Monroy N, Kohgadai N, Usmani SM, Hamil KG, Neidleman J, Montano M, Ständker L, Röcker A, Cavrois M, Rosen J, Marson K, Smith JF, Pilcher CD, Gagsteiger F, Sakk O, O'Rand M, Lishko PV, Kirchhoff F, Münch J, Greene WC. PMID: 28653619; PMCID: PMC5487211.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    46. Mucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells. PLoS Pathog. 2017 02; 13(2):e1006163. Neidleman JA, Chen JC, Kohgadai N, Müller JA, Laustsen A, Thavachelvam K, Jang KS, Stürzel CM, Jones JJ, Ochsenbauer C, Chitre A, Somsouk M, Garcia MM, Smith JF, Greenblatt RM, Münch J, Jakobsen MR, Giudice LC, Greene WC, Roan NR. PMID: 28207890; PMCID: PMC5312882.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    47. Comparison of the effect of semen from HIV-infected and uninfected men on CD4+ T-cell infection. AIDS. 2016 05 15; 30(8):1197-208. Camus C, Matusali G, Bourry O, Mahe D, Aubry F, Bujan L, Pasquier C, Massip P, Ravel C, Zirafi O, Munch J, Roan NR, Pineau C, Dejucq-Rainsford N. PMID: 26854806; PMCID: PMC4856179.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    48. Gallic Acid Is an Antagonist of Semen Amyloid Fibrils That Enhance HIV-1 Infection. J Biol Chem. 2016 Jul 01; 291(27):14045-14055. LoRicco JG, Xu CS, Neidleman J, Bergkvist M, Greene WC, Roan NR, Makhatadze GI. PMID: 27226574; PMCID: PMC4933164.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    49. Amyloid formation: functional friend or fearful foe? J Intern Med. 2016 Aug; 280(2):139-52. Bergman P, Roan NR, Römling U, Bevins CL, Münch J. PMID: 27151743; PMCID: PMC4956559.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    50. Evaluation of EPI-X4 as a urinary peptide biomarker for diagnosis and prognosis of late acute GvHD. Bone Marrow Transplant. 2016 08; 51(8):1137-9. Müller JA, Zirafi O, Roan NR, Lee SJ, Münch J. PMID: 27042833; PMCID: PMC4972659.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    51. Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract. Curr HIV/AIDS Rep. 2016 Feb; 13(1):53-63. Roan NR, Jakobsen MR. PMID: 26879654; PMCID: PMC5408509.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    52. Isolation and Culture of Human Endometrial Epithelial Cells and Stromal Fibroblasts. Bio Protoc. 2015 Oct 20; 5(20). Chen JC, Roan NR. PMID: 27347495; PMCID: PMC4918807.
      View in: PubMed   Mentions: 11  
    53. Improving preclinical models of HIV microbicide efficacy. Trends Microbiol. 2015 Aug; 23(8):445-7. Roan NR, Münch J. PMID: 26250616; PMCID: PMC4818646.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsPHPublic Health
    54. Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides. Sci Transl Med. 2014 Nov 12; 6(262):262ra157. Zirafi O, Kim KA, Roan NR, Kluge SF, Müller JA, Jiang S, Mayer B, Greene WC, Kirchhoff F, Münch J. PMID: 25391483; PMCID: PMC4372245.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    55. Structural characterization of semen coagulum-derived SEM1(86-107) amyloid fibrils that enhance HIV-1 infection. Biochemistry. 2014 May 27; 53(20):3267-77. French KC, Roan NR, Makhatadze GI. PMID: 24811874; PMCID: PMC4039337.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    56. Liquefaction of semen generates and later degrades a conserved semenogelin peptide that enhances HIV infection. J Virol. 2014 Jul; 88(13):7221-34. Roan NR, Liu H, Usmani SM, Neidleman J, Müller JA, Avila-Herrera A, Gawanbacht A, Zirafi O, Chu S, Dong M, Kumar ST, Smith JF, Pollard KS, Fändrich M, Kirchhoff F, Münch J, Witkowska HE, Greene WC. PMID: 24741080; PMCID: PMC4054457.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    57. Interaction of fibronectin with semen amyloids synergistically enhances HIV infection. J Infect Dis. 2014 Oct 01; 210(7):1062-6. Roan NR, Chu S, Liu H, Neidleman J, Witkowska HE, Greene WC. PMID: 24719472; PMCID: PMC4168303.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    58. Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nat Commun. 2014 Apr 01; 5:3508. Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher CD, Gagsteiger F, Fändrich M, Kirchhoff F, Münch J. PMID: 24691351; PMCID: PMC4129123.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    59. Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts. Hum Reprod. 2014 Jun; 29(6):1255-70. Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, Kohgadai N, Irwin JC, Greene WC, Giudice LC, Roan NR. PMID: 24626806; PMCID: PMC4017943.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    60. Seminal plasma and semen amyloids enhance cytomegalovirus infection in cell culture. J Virol. 2013 Dec; 87(23):12583-91. Tang Q, Roan NR, Yamamura Y. PMID: 24027327; PMCID: PMC3838150.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    61. Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses. Nat Nanotechnol. 2013 Feb; 8(2):130-6. Yolamanova M, Meier C, Shaytan AK, Vas V, Bertoncini CW, Arnold F, Zirafi O, Usmani SM, Müller JA, Sauter D, Goffinet C, Palesch D, Walther P, Roan NR, Geiger H, Lunov O, Simmet T, Bohne J, Schrezenmeier H, Schwarz K, Ständker L, Forssmann WG, Salvatella X, Khalatur PG, Khokhlov AR, Knowles TP, Weil T, Kirchhoff F, Münch J. PMID: 23334171.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    62. [Role of semen-derived amyloid fibrils as facilitators of HIV infection]. Med Sci (Paris). 2012 Apr; 28(4):358-60. Roan NR, Cavrois M, Greene WC. PMID: 22549858.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    63. Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection. Cell Host Microbe. 2011 Dec 15; 10(6):541-50. Roan NR, Müller JA, Liu H, Chu S, Arnold F, Stürzel CM, Walther P, Dong M, Witkowska HE, Kirchhoff F, Münch J, Greene WC. PMID: 22177559; PMCID: PMC3257029.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    64. Naturally occurring fragments from two distinct regions of the prostatic acid phosphatase form amyloidogenic enhancers of HIV infection. J Virol. 2012 Jan; 86(2):1244-9. Arnold F, Schnell J, Zirafi O, Stürzel C, Meier C, Weil T, Ständker L, Forssmann WG, Roan NR, Greene WC, Kirchhoff F, Münch J. PMID: 22090109; PMCID: PMC3255800.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    65. Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI. Retrovirology. 2010 Jun 23; 7:55. Kim KA, Yolamanova M, Zirafi O, Roan NR, Staendker L, Forssmann WG, Burgener A, Dejucq-Rainsford N, Hahn BH, Shaw GM, Greene WC, Kirchhoff F, Münch J. PMID: 20573198; PMCID: PMC2914040.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    66. Aminoquinoline surfen inhibits the action of SEVI (semen-derived enhancer of viral infection). J Biol Chem. 2010 Jan 15; 285(3):1861-9. Roan NR, Sowinski S, Münch J, Kirchhoff F, Greene WC. PMID: 19897482; PMCID: PMC2804344.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    67. T cell responses in the absence of IFN-gamma exacerbate uterine infection with Chlamydia trachomatis. J Immunol. 2009 Jul 15; 183(2):1313-9. Gondek DC, Roan NR, Starnbach MN. PMID: 19561106; PMCID: PMC2723820.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    68. The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J Virol. 2009 Jan; 83(1):73-80. Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC. PMID: 18945786; PMCID: PMC2612336.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    69. Conquering sexually transmitted diseases. Nat Rev Immunol. 2008 Apr; 8(4):313-7. Starnbach MN, Roan NR. PMID: 18309315.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansPHPublic Health
    70. Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3831-6. Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang JH, Bell GW, Starnbach MN, Ploegh HL. PMID: 18245382; PMCID: PMC2268777.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    71. A seminal finding for understanding HIV transmission. Cell. 2007 Dec 14; 131(6):1044-6. Roan NR, Greene WC. PMID: 18083095.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    72. Immune-mediated control of Chlamydia infection. Cell Microbiol. 2008 Jan; 10(1):9-19. Roan NR, Starnbach MN. PMID: 17979983.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    73. Antigen-specific CD8+ T cells respond to Chlamydia trachomatis in the genital mucosa. J Immunol. 2006 Dec 01; 177(11):7974-9. Roan NR, Starnbach MN. PMID: 17114470.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    74. Monitoring the T cell response to genital tract infection. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12069-74. Roan NR, Gierahn TM, Higgins DE, Starnbach MN. PMID: 16880389; PMCID: PMC1567698.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    75. Developmental regulation of Chlamydia trachomatis class I accessible protein-1, a CD8+ T cell antigen. J Infect Dis. 2006 May 15; 193(10):1459-63. Balsara ZR, Roan NR, Steele LN, Starnbach MN. PMID: 16619195.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    76. Spt10-dependent transcriptional activation in Saccharomyces cerevisiae requires both the Spt10 acetyltransferase domain and Spt21. Mol Cell Biol. 2004 Jan; 24(1):135-43. Hess D, Liu B, Roan NR, Sternglanz R, Winston F. PMID: 14673149; PMCID: PMC303362.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    77. The Listeria monocytogenes lemA gene product is not required for intracellular infection or to activate fMIGWII-specific T cells. Infect Immun. 2003 Dec; 71(12):6721-7. D'Orazio SE, Velasquez M, Roan NR, Naveiras-Torres O, Starnbach MN. PMID: 14638756; PMCID: PMC308916.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
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