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Sharof Tugizov, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address513 Parnassus Ave, Med Sci
San Francisco CA 94143
Phone415-514-3177
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Overview 
    Collapse Overview
    My current research focuses on the interactions of human viruses, including human immunodeficiency virus and Epstein-Barr virus with oropharyngeal mucosal epithelium. Specifically, I investigate the molecular mechanisms of transepithelial transmission of these viruses through the mucosal epithelium. Understanding viral transmission via the mucosal epithelium is important for preventing the initial steps of viral infection.


    Collapse Research 
    Collapse Research Activities and Funding
    Molecular mechanisms of oral HIV transmission modeling MTCT
    NIH/NIDCR R01DE023315May 1, 2013 - Mar 31, 2018
    Role: Principal Investigator
    HIV transcellular and transsynaptic penetration of mucosal epithelium
    NIH/NIDCR R21DE021011Jul 2, 2010 - Jun 30, 2013
    Role: Principal Investigator
    HIV AND EBV INTERACTION IN ORAL MUCOSAL EPITHELIUM
    NIH/NIDCR R21DE016009Mar 15, 2004 - Feb 28, 2007
    Role: Principal Investigator
    EBV BMRF-2 Protein in Infection of Oral Epithelial Cells
    NIH/NIDCR R01DE014894Jul 10, 2003 - Apr 30, 2010
    Role: Principal Investigator

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    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yasen A, Herrera R, Rosbe K, Lien K, Tugizov S. Release of HIV-1 sequestered in the vesicles of oral and genital mucosal epithelial cells by epithelial-lymphocyte interaction. PLoS Pathog. 2017 Feb; 13(2):e1006247. PMID: 28241053.
      View in: PubMed
    2. Haga T, Efird JT, Tugizov S, Palefsky JM. Increased TNF-alpha and sTNFR2 levels are associated with high-grade anal squamous intraepithelial lesions in HIV-positive patients with low CD4 level. Papillomavirus Res. 2017 Jun; 3:1-6. PMID: 28720441.
      View in: PubMed
    3. Tugizov S. Human immunodeficiency virus-associated disruption of mucosal barriers and its role in HIV transmission and pathogenesis of HIV/AIDS disease. Tissue Barriers. 2016 Jul-Sep; 4(3):e1159276. PMID: 27583187; PMCID: PMC4993574 [Available on 03/03/17].
      View in: PubMed, PubMed Central
    4. Herrera R, Morris M, Rosbe K, Feng Z, Weinberg A, Tugizov S. Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells. Virology. 2016 Jan; 487:172-87. PMID: 26539799.
      View in: PubMed
    5. Sufiawati I, Tugizov S. HIV-associated disruption of tight and adherens junctions of oral epithelial cells facilitates HSV-1 infection and spread. PLoS One. 2014; 9(2):e88803. PMID: 24586397; PMCID: PMC3931628.
      View in: PubMed, PubMed Central
    6. Tugizov S, Herrera R, Chin-Hong P, Veluppillai P, Greenspan D, Michael Berry J, Pilcher CD, Shiboski CH, Jay N, Rubin M, Chein A, Palefsky JM. HIV-associated disruption of mucosal epithelium facilitates paracellular penetration by human papillomavirus. Virology. 2013 Nov; 446(1-2):378-88. PMID: 24074602; PMCID: PMC3809142.
      View in: PubMed, PubMed Central
    7. Tugizov S, Herrera R, Palefsky JM. Epstein-Barr virus transcytosis through polarized oral epithelial cells. J Virol. 2013 Jul; 87(14):8179-94. PMID: 23698302; PMCID: PMC3700193.
      View in: PubMed, PubMed Central
    8. Tugizov S, Herrera R, Veluppillai P, Greenspan D, Soros V, Greene WC, Levy JA, Palefsky JM. Differential transmission of HIV traversing fetal oral/intestinal epithelia and adult oral epithelia. J Virol. 2012 Mar; 86(5):2556-70. PMID: 22205732; PMCID: PMC3302289.
      View in: PubMed, PubMed Central
    9. Challacombe SJ, Fidel PL, Tugizov S, Tao L, Wahl SM. HIV infection and specific mucosal immunity: workshop 4B. Adv Dent Res. 2011 Apr; 23(1):142-51. PMID: 21441496.
      View in: PubMed
    10. Tugizov S, Webster-Cyriaque JY, Syrianen S, Chattopadyay A, Sroussi H, Zhang L, Kaushal A. Mechanisms of viral infections associated with HIV: workshop 2B. Adv Dent Res. 2011 Apr; 23(1):130-6. PMID: 21441494.
      View in: PubMed
    11. Weinberg A, Naglik JR, Kohli A, Tugizov S, Fidel PL, Liu Y, Herzberg M. Innate immunity including epithelial and nonspecific host factors: workshop 1B. Adv Dent Res. 2011 Apr; 23(1):122-9. PMID: 21441493.
      View in: PubMed
    12. Tugizov S, Herrera R, Veluppillai P, Greenspan D, Soros V, Greene WC, Levy JA, Palefsky JM. HIV is inactivated after transepithelial migration via adult oral epithelial cells but not fetal epithelial cells. Virology. 2011 Jan 20; 409(2):211-22. PMID: 21056450; PMCID: PMC3034249.
      View in: PubMed, PubMed Central
    13. Dorner M, Zucol F, Alessi D, Haerle SK, Bossart W, Weber M, Byland R, Bernasconi M, Berger C, Tugizov S, Speck RF, Nadal D. beta1 integrin expression increases susceptibility of memory B cells to Epstein-Barr virus infection. J Virol. 2010 Jul; 84(13):6667-77. PMID: 20427540; PMCID: PMC2903285.
      View in: PubMed, PubMed Central
    14. Xiao J, Palefsky JM, Herrera R, Sunshine C, Tugizov S. EBV-positive human sera contain antibodies against the EBV BMRF-2 protein. Virology. 2009 Oct 10; 393(1):151-9. PMID: 19698968; PMCID: PMC2771626.
      View in: PubMed, PubMed Central
    15. Xiao J, Palefsky JM, Herrera R, Berline J, Tugizov S. EBV BMRF-2 facilitates cell-to-cell spread of virus within polarized oral epithelial cells. Virology. 2009 Jun 05; 388(2):335-43. PMID: 19394065; PMCID: PMC2726254.
      View in: PubMed, PubMed Central
    16. Haga T, Uchide N, Tugizov S, Palefsky JM. Role of E-cadherin in the induction of apoptosis of HPV16-positive CaSki cervical cancer cells during multicellular tumor spheroid formation. Apoptosis. 2008 Jan; 13(1):97-108. PMID: 17906929.
      View in: PubMed
    17. Xiao J, Palefsky JM, Herrera R, Berline J, Tugizov S. The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells. Virology. 2008 Jan 20; 370(2):430-42. PMID: 17945327; PMCID: PMC2268893.
      View in: PubMed, PubMed Central
    18. Tugizov S, Herrera R, Veluppillai P, Greenspan J, Greenspan D, Palefsky JM. Epstein-Barr virus (EBV)-infected monocytes facilitate dissemination of EBV within the oral mucosal epithelium. J Virol. 2007 Jun; 81(11):5484-96. PMID: 17376918; PMCID: PMC1900306.
      View in: PubMed, PubMed Central
    19. Xiao J, Palefsky JM, Herrera R, Tugizov S. Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Virology. 2007 Mar 15; 359(2):382-96. PMID: 17081581.
      View in: PubMed
    20. Tugizov S, Berline J, Herrera R, Penaranda ME, Nakagawa M, Palefsky J. Inhibition of human papillomavirus type 16 E7 phosphorylation by the S100 MRP-8/14 protein complex. J Virol. 2005 Jan; 79(2):1099-112. PMID: 15613338; PMCID: PMC538578.
      View in: PubMed, PubMed Central
    21. Tugizov S, Berline JW, Palefsky JM. Epstein-Barr virus infection of polarized tongue and nasopharyngeal epithelial cells. Nat Med. 2003 Mar; 9(3):307-14. PMID: 12592401.
      View in: PubMed
    22. Tugizov S, Maidji E, Xiao J, Pereira L. An acidic cluster in the cytosolic domain of human cytomegalovirus glycoprotein B is a signal for endocytosis from the plasma membrane. J Virol. 1999 Oct; 73(10):8677-88. PMID: 10482621; PMCID: PMC112888.
      View in: PubMed, PubMed Central
    23. Tugizov S, Maidji E, Xiao J, Zheng Z, Pereira L. Human cytomegalovirus glycoprotein B contains autonomous determinants for vectorial targeting to apical membranes of polarized epithelial cells. J Virol. 1998 Sep; 72(9):7374-86. PMID: 9696834; PMCID: PMC109962.
      View in: PubMed, PubMed Central
    24. Maidji E, Tugizov S, Abenes G, Jones T, Pereira L. A novel human cytomegalovirus glycoprotein, gpUS9, which promotes cell-to-cell spread in polarized epithelial cells, colocalizes with the cytoskeletal proteins E-cadherin and F-actin. J Virol. 1998 Jul; 72(7):5717-27. PMID: 9621030; PMCID: PMC110243.
      View in: PubMed, PubMed Central
    25. Navarro D, Lennette E, Tugizov S, Pereira L. Humoral immune response to functional regions of human cytomegalovirus glycoprotein B. J Med Virol. 1997 Aug; 52(4):451-9. PMID: 9260696.
      View in: PubMed
    26. Maidji E, Tugizov S, Jones T, Zheng Z, Pereira L. Accessory human cytomegalovirus glycoprotein US9 in the unique short component of the viral genome promotes cell-to-cell transmission of virus in polarized epithelial cells. J Virol. 1996 Dec; 70(12):8402-10. PMID: 8970961; PMCID: PMC190929.
      View in: PubMed, PubMed Central
    27. Zheng Z, Maidji E, Tugizov S, Pereira L. Mutations in the carboxyl-terminal hydrophobic sequence of human cytomegalovirus glycoprotein B alter transport and protein chaperone binding. J Virol. 1996 Nov; 70(11):8029-40. PMID: 8892927; PMCID: PMC190876.
      View in: PubMed, PubMed Central
    28. Tugizov S, Maidji E, Pereira L. Role of apical and basolateral membranes in replication of human cytomegalovirus in polarized retinal pigment epithelial cells. J Gen Virol. 1996 Jan; 77 ( Pt 1):61-74. PMID: 8558129.
      View in: PubMed
    29. Tugizov S, Wang Y, Qadri I, Navarro D, Maidji E, Pereira L. Mutated forms of human cytomegalovirus glycoprotein B are impaired in inducing syncytium formation. Virology. 1995 Jun 01; 209(2):580-91. PMID: 7778290.
      View in: PubMed
    30. Ramakrishnan M, Tugizov S, Pereira L, Lee AS. Conformation-defective herpes simplex virus 1 glycoprotein B activates the promoter of the grp94 gene that codes for the 94-kD stress protein in the endoplasmic reticulum. DNA Cell Biol. 1995 May; 14(5):373-84. PMID: 7748487.
      View in: PubMed
    31. Pereira L, Maidji E, Tugizov S, Jones T. Deletion mutants in human cytomegalovirus glycoprotein US9 are impaired in cell-cell transmission and in altering tight junctions of polarized human retinal pigment epithelial cells. Scand J Infect Dis Suppl. 1995; 99:82-7. PMID: 8668948.
      View in: PubMed
    32. Tugizov S, Navarro D, Paz P, Wang Y, Qadri I, Pereira L. Function of human cytomegalovirus glycoprotein B: syncytium formation in cells constitutively expressing gB is blocked by virus-neutralizing antibodies. Virology. 1994 Jun; 201(2):263-76. PMID: 8184537.
      View in: PubMed
    33. Tugizov S, Savchenkova IP, Grabovskaya IL, Makarova NE, Eraizer TL, Revazova EP, Kushch AA. Changes in expression of surface and core antigens of hepatitis B virus in different mutant clones of hepatoma PLC-PRF-5 cells. Virus Res. 1993 Nov; 30(2):189-203. PMID: 8249446.
      View in: PubMed
    34. Navarro D, Paz P, Tugizov S, Topp K, La Vail J, Pereira L. Glycoprotein B of human cytomegalovirus promotes virion penetration into cells, transmission of infection from cell to cell, and fusion of infected cells. Virology. 1993 Nov; 197(1):143-58. PMID: 7692667.
      View in: PubMed
    35. Grabovskaya IL, Tugizov S, Glukhova LA, Kushch AA. Cytogenetic analysis of human hepatocarcinoma cell line PLC-PRF-5 and its mutant clones with different degrees of cell differentiation. Cancer Genet Cytogenet. 1993 Feb; 65(2):147-51. PMID: 8384075.
      View in: PubMed
    36. Tugizov S, Savchenkova IP, Grabovskaia IL, Kushch AA. [Changes in the gene expression of the hepatitis B virus in PLC-PRF-5 cells of human hepatocarcinoma during their acquisition of drug resistance]. Vopr Virusol. 1992 Sep-Dec; 37(5-6):238-41. PMID: 1337803.
      View in: PubMed
    37. Shumai EP, Vorob'ev SM, Makarova NE, Tugizov S, Zverev VV, Kushch AA. [The immunoenzyme detection of the HIV-1 antigen by using monoclonal antibodies to protein p24]. Vopr Virusol. 1992 Sep-Dec; 37(5-6):229-32. PMID: 1290220.
      View in: PubMed
    38. Kushch AA, Tugizov S, Terletskaia EN, Posevaia TA, Nikitina AA, L'vov ND, Barinskii IF. [Human hybridoma neutralizing antibodies to the herpes simplex virus]. Vopr Virusol. 1992 Sep-Dec; 37(5-6):264-6. PMID: 1337804.
      View in: PubMed
    39. El'bert LB, Vorovich MF, Terletskaia EN, Lisitsina EA, Atanadze SN, Sidorovich IG, Khozinskii VV, Tugizov S, Kushch AA, Khapchaev IuKh. [The protective activity of preparations made from the tick-borne encephalitis virus grown using different cell cultures]. Zh Mikrobiol Epidemiol Immunobiol. 1992 Jan; (1):25-8. PMID: 1414102.
      View in: PubMed
    40. Filatov FP, Tugizov S, Savchenkova IP, Kumarev VP, Belikov AS, Kadoshnikov IuP, Kush AA, Uryvaev LV. [Recombinant surface proteins of the hepatitis B virus, exhibiting the immunodominant membrane protein of the HIV-1 virus]. Dokl Akad Nauk. 1992; 327(1):172-5. PMID: 1486344.
      View in: PubMed
    41. Shpilevaia MV, Tugizov S, Kushch AA, Tsilinskii IaIa, Makarova NE. [The biological and immunochemical properties of monoclonal antibodies to the Venezuelan equine encephalomyelitis virus]. Vopr Virusol. 1991 Nov-Dec; 36(6):495-8. PMID: 1723821.
      View in: PubMed
    42. Kushch AA, Tugizov S, Simonov VI, Timofeev IV, Perminova NP, Shumai EP. [The properties of monoclonal antibodies to HIV gag gene proteins]. Vopr Virusol. 1991 Jul-Aug; 36(4):275-7. PMID: 1796579.
      View in: PubMed
    43. Vorovich MF, Timofeev AV, Atanadze SN, Tugizov S, Sidorovich IG, Khozinskii VV, Kushch AA, El'bert LB. [The inhibition of the pH-dependent fusion of the tick-borne encephalitis virus with artificial membranes by using non-neutralizing monoclonal antibodies]. Dokl Akad Nauk SSSR. 1991; 316(1):231-4. PMID: 2055152.
      View in: PubMed
    44. Vorovitch MF, Timofeev AV, Atanadze SN, Tugizov S, Kushch AA, Elbert LB. pH-dependent fusion of tick-borne encephalitis virus with artificial membranes. Arch Virol. 1991; 118(1-2):133-8. PMID: 2048972.
      View in: PubMed
    45. Kushch AA, Beliavskii AV, Shumai EP, Tugizov S, Ovcharenko AV. [Monoclonal antibodies against topoisomerase I inhibit cell entering into the phase of DNA synthesis]. Dokl Akad Nauk SSSR. 1988; 300(4):968-71. PMID: 2844486.
      View in: PubMed
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