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Christopher Pilcher

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-476-4082 ext. 403
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityAB1986Biology
    University of Vermont College of MedicineMD1993Medicine
    Oxford University John Radcliffe HospitalSenior House Officer1996Paediatrics
    Duke University Medical CenterResidency1997Internal Medicine and Pediatrics
    University of North Carolina at Chapel HillFellowship2000Infectious Diseases

    Collapse Research 
    Collapse Research Activities and Funding
    A Pilot of Intervention to Promote Acute HIV Testing by Ambulatory Care Providers
    NIH/NIMH R34MH096606Sep 7, 2012 - Jun 30, 2015
    Role: Principal Investigator
    Host Factors Influencing HIV Viral Load and Infectivity in Semen
    NIH/NICHD R01HD074511Jul 25, 2012 - May 31, 2017
    Role: Principal Investigator
    Targeting Acute HIV
    NIH/NIMH R01MH068686Sep 19, 2003 - Jun 30, 2010
    Role: Principal Investigator
    CYTOREDUCTIVE CHEMOTHERAPY TARGETING HIV RESERVOIRS
    NIH/NIAID K23AI001781Jul 1, 2000 - Jun 30, 2005
    Role: Principal Investigator
    General Clinical Research Center
    NIH M01RR000046Oct 1, 1974 - May 31, 2008
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Grebe E, Welte A, Hall J, Keating SM, Facente SN, Marson K, Martin JN, Little SJ, Price MA, Kallas EG, Busch MP, Pilcher C, Murphy G. Infection Staging and Incidence Surveillance Applications of High Dynamic Range Diagnostic Immuno-Assay Platforms. J Acquir Immune Defic Syndr. 2017 Sep 07. PMID: 28914669.
      View in: PubMed
    2. de Mulder M, SenGupta D, Deeks SG, Martin JN, Pilcher C, Hecht FM, Sacha JB, Nixon DF, Michaud HA. Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers. Retrovirology. 2017 Aug 22; 14(1):41. PMID: 28830571.
      View in: PubMed
    3. Keating SM, Pilcher C, Jain V, Lebedeva M, Hampton D, Abdel-Mohsen M, Deng X, Murphy G, Welte A, Facente SN, Hecht F, Deeks SG, Pillai SK, Busch MP. HIV Antibody Level as a Marker of HIV Persistence and Low-Level Viral Replication. J Infect Dis. 2017 Jul 01; 216(1):72-81. PMID: 28498985.
      View in: PubMed
    4. Rutstein SE, Ananworanich J, Fidler S, Johnson C, Sanders EJ, Sued O, Saez-Cirion A, Pilcher C, Fraser C, Cohen MS, Vitoria M, Doherty M, Tucker JD. Clinical and public health implications of acute and early HIV detection and treatment: a scoping review. J Int AIDS Soc. 2017 06 28; 20(1):21579. PMID: 28691435.
      View in: PubMed
    5. Rutishauser R, Hartogensis W, Deguit CD, Krone M, Hoh R, Hecht R, Pilcher C, Bacchetti P, Deeks SG, Hunt PW, McCune JM. Early and Delayed Antiretroviral Therapy Results in Comparable Reductions in CD8+ T Cell Exhaustion Marker Expression. AIDS Res Hum Retroviruses. 2017 Jul; 33(7):658-667. PMID: 28335609.
      View in: PubMed
    6. Marson KG, Marlin R, Pham P, Cohen SE, Jones D, Roemer M, Peters PJ, Haller B, Pilcher C. Real-world performance of the new US HIV testing algorithm in medical settings. J Clin Virol. 2017 Jun; 91:73-78. PMID: 28434809.
      View in: PubMed
    7. Christopoulos KA, Hartogensis W, Glidden DV, Pilcher C, Gandhi M, Geng EH. Limitations of using the Lorenz curve framework to understand the distribution of population viral load: authors' reply. AIDS. 2017 Mar 13; 31(5):742-743. PMID: 28225455.
      View in: PubMed
    8. Schlusser KE, Pilcher C, Kallas EG, Santos BR, Deeks SG, Facente S, Keating SM, Busch MP, Murphy G, Welte A, Quinn T, Eshleman SH, Laeyendecker O. Comparison of cross-sectional HIV incidence assay results from dried blood spots and plasma. PLoS One. 2017; 12(2):e0172283. PMID: 28231277.
      View in: PubMed
    9. Christopoulos K, Hartogensis W, Glidden DV, Pilcher C, Gandhi M, Geng EH. The Lorenz curve: a novel method for understanding viral load distribution at the population level. AIDS. 2017 Jan 14; 31(2):309-310. PMID: 27831945.
      View in: PubMed
    10. Pilcher C, Ospina-Norvell C, Dasgupta A, Jones D, Hartogensis W, Torres S, Calderon F, Demicco E, Geng E, Gandhi M, Havlir DV, Hatano H. The Effect of Same-Day Observed Initiation of Antiretroviral Therapy on HIV Viral Load and Treatment Outcomes in a US Public Health Setting. J Acquir Immune Defic Syndr. 2017 Jan 01; 74(1):44-51. PMID: 27434707.
      View in: PubMed
    11. Murphy G, Pilcher C, Keating SM, Kassanjee R, Facente SN, Welte A, Grebe E, Marson K, Busch MP, Dailey P, Parkin N, Osborn J, Ongarello S, Marsh K, Garcia-Calleja JM. Moving towards a reliable HIV incidence test - current status, resources available, future directions and challenges ahead. Epidemiol Infect. 2017 Apr; 145(5):925-941. PMID: 28004622.
      View in: PubMed
    12. Keating SM, Kassanjee R, Lebedeva M, Facente SN, MacArthur JC, Grebe E, Murphy G, Welte A, Martin JN, Little S, Price MA, Kallas EG, Busch MP, Pilcher C. Performance of the Bio-Rad Geenius HIV1/2 Supplemental Assay in Detecting "Recent" HIV Infection and Calculating Population Incidence. J Acquir Immune Defic Syndr. 2016 Dec 15; 73(5):581-588. PMID: 27509247.
      View in: PubMed
    13. Kassanjee R, Pilcher C, Busch MP, Murphy G, Facente SN, Keating SM, Mckinney E, Marson K, Price MA, Martin JN, Little SJ, Hecht FM, Kallas EG, Welte A. Viral load criteria and threshold optimization to improve HIV incidence assay characteristics. AIDS. 2016 Sep 24; 30(15):2361-71. PMID: 27454561; PMCID: PMC5024345 [Available on 09/24/17].
    14. Keating SM, Pilcher C, Busch MP. Editorial Commentary: Timing Is Everything: Shortcomings of Current HIV Diagnostics in the Early Treatment Era. Clin Infect Dis. 2016 Aug 15; 63(4):562-4. PMID: 27317798.
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    15. Gearhart TL, Montelaro RC, Schurdak ME, Pilcher C, Rinaldo CR, Kodadek T, Park Y, Islam K, Yurko R, Marques ET, Burke DS. Selection of a potential diagnostic biomarker for HIV infection from a random library of non-biological synthetic peptoid oligomers. J Immunol Methods. 2016 Aug; 435:85-9. PMID: 27182050; PMCID: PMC4947968.
    16. Vujkovic-Cvijin I, Swainson LA, Chu SN, Ortiz AM, Santee CA, Petriello A, Dunham RM, Fadrosh DW, Lin DL, Faruqi AA, Huang Y, Apetrei C, Pandrea I, Hecht FM, Pilcher C, Klatt NR, Brenchley JM, Lynch SV, McCune JM. Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques. Cell Rep. 2015 Nov 24; 13(8):1589-97. PMID: 26586432; PMCID: PMC4782968.
    17. Pilcher C, Bisol CA, Paganella MP, Vallabhaneni S, da Motta LR, Kato SK, Sperhacke RD, Kallas EG, Hecht FM, Diaz RS. Efficient Identification of HIV Serodiscordant Couples by Existing HIV Testing Programs in South Brazil. PLoS One. 2015; 10(11):e0142638. PMID: 26562436; PMCID: PMC4642994.
    18. Eriksson EM, Liegler T, Keh CE, Karlsson AC, Holditch SJ, Pilcher C, Loeb L, Nixon DF, Hecht FM. Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences. PLoS One. 2014; 10(4):e0120787. PMID: 25919393; PMCID: PMC4412704.
    19. von Stockenstrom S, Odevall L, Lee E, Sinclair E, Bacchetti P, Killian M, Epling L, Shao W, Hoh R, Ho T, Faria NR, Lemey P, Albert J, Hunt P, Loeb L, Pilcher C, Poole L, Hatano H, Somsouk M, Douek D, Boritz E, Deeks SG, Hecht FM, Palmer S. Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV Therapy. J Infect Dis. 2015 Aug 15; 212(4):596-607. PMID: 25712966; PMCID: PMC4539896.
    20. Abdel-Mohsen M, Wang C, Strain MC, Lada SM, Deng X, Cockerham LR, Pilcher C, Hecht FM, Liegler T, Richman DD, Deeks SG, Pillai SK. Select host restriction factors are associated with HIV persistence during antiretroviral therapy. AIDS. 2015 Feb 20; 29(4):411-20. PMID: 25602681; PMCID: PMC4385712.
    21. Rosenberg NE, Pilcher C, Busch MP, Cohen MS. How can we better identify early HIV infections? Curr Opin HIV AIDS. 2015 Jan; 10(1):61-8. PMID: 25389806; PMCID: PMC4490585.
    22. Hollingsworth TD, Pilcher C, Hecht FM, Deeks SG, Fraser C. High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men-San Francisco, California. J Infect Dis. 2015 Jun 01; 211(11):1757-60. PMID: 25542958; PMCID: PMC4425938.
    23. Kassanjee R, Pilcher C, Keating SM, Facente SN, McKinney E, Price MA, Martin JN, Little S, Hecht FM, Kallas EG, Welte A, Busch MP, Murphy G. Independent assessment of candidate HIV incidence assays on specimens in the CEPHIA repository. AIDS. 2014 Oct 23; 28(16):2439-49. PMID: 25144218; PMCID: PMC4210690.
    24. Cockerham LR, Jain V, Sinclair E, Glidden DV, Hartogenesis W, Hatano H, Hunt PW, Martin JN, Pilcher C, Sekaly R, McCune JM, Hecht FM, Deeks SG. Programmed death-1 expression on CD4? and CD8? T cells in treated and untreated HIV disease. AIDS. 2014 Jul 31; 28(12):1749-58. PMID: 24871455; PMCID: PMC4206412.
    25. Raposo RA, Abdel-Mohsen M, Deng X, Hecht FM, Pilcher C, Pillai SK, Nixon DF. Dynamic regulation of host restriction factor expression over the course of HIV-1 infection in vivo. J Virol. 2014 Oct; 88(19):11624-9. PMID: 25031350; PMCID: PMC4178813.
    26. Wang C, Abdel-Mohsen M, Strain MC, Lada SM, Yukl S, Cockerham LR, Pilcher C, Hecht FM, Sinclair E, Liegler T, Richman DD, Deeks SG, Pillai SK. Decreased HIV type 1 transcription in CCR5-?32 heterozygotes during suppressive antiretroviral therapy. J Infect Dis. 2014 Dec 01; 210(11):1838-43. PMID: 24935955; PMCID: PMC4271057.
    27. Gold JA, Grill M, Peterson J, Pilcher C, Lee E, Hecht FM, Fuchs D, Yiannoutsos CT, Price RW, Robertson K, Spudich S. Longitudinal characterization of depression and mood states beginning in primary HIV infection. AIDS Behav. 2014 Jun; 18(6):1124-32. PMID: 24385231.
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    28. Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher C, Gagsteiger F, Fändrich M, Kirchhoff F, Münch J. Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nat Commun. 2014 Apr 01; 5:3508. PMID: 24691351; PMCID: PMC4129123.
    29. Burns DN, DeGruttola V, Pilcher C, Kretzschmar M, Gordon CM, Flanagan EH, Duncombe C, Cohen MS. Toward an endgame: finding and engaging people unaware of their HIV-1 infection in treatment and prevention. AIDS Res Hum Retroviruses. 2014 Mar; 30(3):217-24. PMID: 24410300; PMCID: PMC3938938.
    30. Michaud HA, de Mulder M, SenGupta D, Deeks SG, Martin JN, Pilcher C, Hecht FM, Sacha JB, Nixon DF. Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection. Retrovirology. 2014 Jan 28; 11:10. PMID: 24472118; PMCID: PMC3907665.
    31. Pilcher C, Louie B, Facente S, Keating S, Hackett J, Vallari A, Hall C, Dowling T, Busch MP, Klausner JD, Hecht FM, Liska S, Pandori MW. Performance of rapid point-of-care and laboratory tests for acute and established HIV infection in San Francisco. PLoS One. 2013; 8(12):e80629. PMID: 24349007; PMCID: PMC3861178.
    32. Ooms M, Brayton B, Letko M, Maio SM, Pilcher C, Hecht FM, Barbour JD, Simon V. HIV-1 Vif adaptation to human APOBEC3H haplotypes. Cell Host Microbe. 2013 Oct 16; 14(4):411-21. PMID: 24139399.
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    33. Crawford TQ, Hecht FM, Pilcher C, Ndhlovu LC, Barbour JD. Activation associated ERK1/2 signaling impairments in CD8+ T cells co-localize with blunted polyclonal and HIV-1 specific effector functions in early untreated HIV-1 infection. PLoS One. 2013; 8(10):e77412. PMID: 24143233; PMCID: PMC3797111.
    34. Tugizov SM, Herrera R, Chin-Hong P, Veluppillai P, Greenspan D, Michael Berry J, Pilcher C, Shiboski CH, Jay N, Rubin M, Chein A, Palefsky JM. HIV-associated disruption of mucosal epithelium facilitates paracellular penetration by human papillomavirus. Virology. 2013 Nov; 446(1-2):378-88. PMID: 24074602; PMCID: PMC3809142.
    35. Christopoulos KA, Massey AD, Lopez AM, Hare CB, Johnson MO, Pilcher C, Fielding H, Dawson-Rose C. Patient perspectives on the experience of being newly diagnosed with HIV in the emergency department/urgent care clinic of a public hospital. PLoS One. 2013; 8(8):e74199. PMID: 23991214; PMCID: PMC3753265.
    36. Jain V, Hartogensis W, Bacchetti P, Hunt PW, Hatano H, Sinclair E, Epling L, Lee TH, Busch MP, McCune JM, Pilcher C, Hecht FM, Deeks SG. Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size. J Infect Dis. 2013 Oct 15; 208(8):1202-11. PMID: 23852127; PMCID: PMC3778965.
    37. Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG. Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient. PLoS Pathog. 2013; 9(5):e1003347. PMID: 23671416; PMCID: PMC3649997.
    38. Christopoulos KA, Massey AD, Lopez AM, Geng EH, Johnson MO, Pilcher C, Fielding H, Dawson-Rose C. "Taking a half day at a time:" patient perspectives and the HIV engagement in care continuum. AIDS Patient Care STDS. 2013 Apr; 27(4):223-30. PMID: 23565926; PMCID: PMC3661033.
    39. Champiat S, Garrison KE, Raposo RA, Burwitz BJ, Reed J, Tandon R, York VA, Newman LP, Nimityongskul FA, Wilson NA, Almeida RR, Martin JN, Deeks SG, Rosenberg MG, Wiznia AA, Spotts GE, Pilcher C, Hecht FM, Ostrowski MA, Sacha JB, Nixon DF. T cells target APOBEC3 proteins in human immunodeficiency virus type 1-infected humans and simian immunodeficiency virus-infected Indian rhesus macaques. J Virol. 2013 Jun; 87(11):6073-80. PMID: 23536679; PMCID: PMC3648095.
    40. Vallabhaneni S, McConnell JJ, Loeb L, Hartogensis W, Hecht FM, Grant RM, Pilcher C. Changes in seroadaptive practices from before to after diagnosis of recent HIV infection among men who have sex with men. PLoS One. 2013; 8(2):e55397. PMID: 23405145; PMCID: PMC3566177.
    41. Christopoulos KA, Zetola NM, Klausner JD, Haller B, Louie B, Hare CB, Pandori M, Nassos P, Roemer M, Pilcher C. Leveraging a rapid, round-the-clock HIV testing system to screen for acute HIV infection in a large urban public medical center. J Acquir Immune Defic Syndr. 2013 Feb 01; 62(2):e30-8. PMID: 23117503; PMCID: PMC3548997.
    42. Vallabhaneni S, Li X, Vittinghoff E, Donnell D, Pilcher C, Buchbinder SP. Seroadaptive practices: association with HIV acquisition among HIV-negative men who have sex with men. PLoS One. 2012; 7(10):e45718. PMID: 23056215; PMCID: PMC3463589.
    43. Champiat S, Raposo RA, Maness NJ, Lehman JL, Purtell SE, Hasenkrug AM, Miller JC, Dean H, Koff WC, Hong MA, Martin JN, Deeks SG, Spotts GE, Pilcher C, Hecht FM, Kallas EG, Garrison KE, Nixon DF. Influence of HAART on alternative reading frame immune responses over the course of HIV-1 infection. PLoS One. 2012; 7(6):e39311. PMID: 22768072; PMCID: PMC3387156.
    44. Hampton KH, Serre ML, Gesink DC, Pilcher C, Miller WC. Adjusting for sampling variability in sparse data: geostatistical approaches to disease mapping. Int J Health Geogr. 2011 Oct 06; 10:54. PMID: 21978359; PMCID: PMC3204220.
    45. Hecht FM, Wellman R, Busch MP, Pilcher C, Norris PJ, Margolick JB, Collier AC, Little SJ, Markowitz M, Routy JP, Holte S. Identifying the early post-HIV antibody seroconversion period. J Infect Dis. 2011 Aug 15; 204(4):526-33. PMID: 21791654; PMCID: PMC3144168.
    46. Facente SN, Pilcher C, Hartogensis WE, Klausner JD, Philip SS, Louie B, Christopoulos KA, Dowling T, Colfax GN. Performance of risk-based criteria for targeting acute HIV screening in San Francisco. PLoS One. 2011; 6(7):e21813. PMID: 21755003; PMCID: PMC3130783.
    47. Powers KA, Hoffman IF, Ghani AC, Hosseinipour MC, Pilcher C, Price MA, Pettifor AE, Chilongozi DA, Martinson FE, Cohen MS, Miller WC. Sexual partnership patterns in malawi: implications for HIV/STI transmission. Sex Transm Dis. 2011 Jul; 38(7):657-66. PMID: 21301383; PMCID: PMC3125407.
    48. Jain V, Sucupira MC, Bacchetti P, Hartogensis W, Diaz RS, Kallas EG, Janini LM, Liegler T, Pilcher C, Grant RM, Cortes R, Deeks SG, Hecht FM. Differential persistence of transmitted HIV-1 drug resistance mutation classes. J Infect Dis. 2011 Apr 15; 203(8):1174-81. PMID: 21451005; PMCID: PMC3107558.
    49. Jain V, Liegler T, Vittinghoff E, Hartogensis W, Bacchetti P, Poole L, Loeb L, Pilcher C, Grant RM, Deeks SG, Hecht FM. Transmitted drug resistance in persons with acute/early HIV-1 in San Francisco, 2002-2009. PLoS One. 2010 Dec 10; 5(12):e15510. PMID: 21170322; PMCID: PMC3000814.
    50. Busch MP, Pilcher C, Mastro TD, Kaldor J, Vercauteren G, Rodriguez W, Rousseau C, Rehle TM, Welte A, Averill MD, Garcia Calleja JM. Beyond detuning: 10 years of progress and new challenges in the development and application of assays for HIV incidence estimation. AIDS. 2010 Nov 27; 24(18):2763-71. PMID: 20975514.
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    51. Hsiang MS, Lin M, Dokomajilar C, Kemere J, Pilcher C, Dorsey G, Greenhouse B. PCR-based pooling of dried blood spots for detection of malaria parasites: optimization and application to a cohort of Ugandan children. J Clin Microbiol. 2010 Oct; 48(10):3539-43. PMID: 20686079; PMCID: PMC2953134.
    52. Bebell LM, Pilcher C, Dorsey G, Havlir D, Kamya MR, Busch MP, Dunn Williams J, Nugent CT, Bentsen C, Rosenthal PJ, Charlebois ED. Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria. AIDS. 2010 Jul 31; 24(12):1945-52. PMID: 20543656; PMCID: PMC2909782.
    53. Pilcher C, Christopoulos KA, Golden M. Public health rationale for rapid nucleic acid or p24 antigen tests for HIV. J Infect Dis. 2010 Apr 15; 201 Suppl 1:S7-15. PMID: 20225950.
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    54. Hulgan T, Donahue JP, Smeaton L, Pu M, Wang H, Lederman MM, Smith K, Valdez H, Pilcher C, Haas DW. Oral cyclosporin A inhibits CD4 T cell P-glycoprotein activity in HIV-infected adults initiating treatment with nucleoside reverse transcriptase inhibitors. Eur J Clin Pharmacol. 2009 Nov; 65(11):1081-8. PMID: 19779705; PMCID: PMC2873632.
    55. McCoy SI, Eron JJ, Kuruc JD, Strauss RP, Macdonald PD, Fiscus SA, Barnhart J, Pilcher C, Leone PA, Miller WC. Sexually transmitted infections among patients with acute HIV in North Carolina. Sex Transm Dis. 2009 Jun; 36(6):372-4. PMID: 19387421; PMCID: PMC2708082.
    56. Miller WC, Leone PA, McCoy S, Nguyen TQ, Williams DE, Pilcher C. Targeted testing for acute HIV infection in North Carolina. AIDS. 2009 Apr 27; 23(7):835-43. PMID: 19318909; PMCID: PMC2828678.
    57. Nugent CT, Dockter J, Bernardin F, Hecht R, Smith D, Delwart E, Pilcher C, Richman D, Busch M, Giachetti C. Detection of HIV-1 in alternative specimen types using the APTIMA HIV-1 RNA Qualitative Assay. J Virol Methods. 2009 Jul; 159(1):10-4. PMID: 19442838; PMCID: PMC2930826.
    58. Hurt CB, McCoy SI, Kuruc J, Nelson JA, Kerkau M, Fiscus S, McGee K, Sebastian J, Leone P, Pilcher C, Hicks C, Eron J. Transmitted antiretroviral drug resistance among acute and recent HIV infections in North Carolina from 1998 to 2007. Antivir Ther. 2009; 14(5):673-8. PMID: 19704170; PMCID: PMC2860724.
    59. Pilcher C, Hare CB. The deadliest catch: fishing for HIV in new waters. Ann Intern Med. 2008 Aug 05; 149(3):204-5. PMID: 18678848.
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    60. Westreich DJ, Hudgens MG, Fiscus SA, Pilcher C. Optimizing screening for acute human immunodeficiency virus infection with pooled nucleic acid amplification tests. J Clin Microbiol. 2008 May; 46(5):1785-92. PMID: 18353930; PMCID: PMC2395100.
    61. Pilcher C, Wong JK, Pillai SK. Inferring HIV transmission dynamics from phylogenetic sequence relationships. PLoS Med. 2008 Mar 18; 5(3):e69. PMID: 18351799; PMCID: PMC2267810.
    62. Daar ES, Pilcher C, Hecht FM. Clinical presentation and diagnosis of primary HIV-1 infection. Curr Opin HIV AIDS. 2008 Jan; 3(1):10-5. PMID: 19372938.
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    63. Patterson KB, Leone PA, Fiscus SA, Kuruc J, McCoy SI, Wolf L, Foust E, Williams D, Eron JJ, Pilcher C. Frequent detection of acute HIV infection in pregnant women. AIDS. 2007 Nov 12; 21(17):2303-8. PMID: 18090278.
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    64. Powers KA, Miller WC, Pilcher C, Mapanje C, Martinson FE, Fiscus SA, Chilongozi DA, Namakhwa D, Price MA, Galvin SR, Hoffman IF, Cohen MS. Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithm. AIDS. 2007 Oct 18; 21(16):2237-42. PMID: 18090052; PMCID: PMC2673577.
    65. Pilcher C, Joaki G, Hoffman IF, Martinson FE, Mapanje C, Stewart PW, Powers KA, Galvin S, Chilongozi D, Gama S, Price MA, Fiscus SA, Cohen MS. Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection. AIDS. 2007 Aug 20; 21(13):1723-30. PMID: 17690570; PMCID: PMC2673564.
    66. Kim HY, Hudgens MG, Dreyfuss JM, Westreich DJ, Pilcher C. Comparison of group testing algorithms for case identification in the presence of test error. Biometrics. 2007 Dec; 63(4):1152-63. PMID: 17501946.
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    67. Gulick RM, Lalama CM, Ribaudo HJ, Shikuma CM, Schackman BR, Schouten J, Squires KE, Koletar SL, Pilcher C, Reichman RC, Klingman KL, Kuritzkes DR. Intensification of a triple-nucleoside regimen with tenofovir or efavirenz in HIV-1-infected patients with virological suppression. AIDS. 2007 Apr 23; 21(7):813-23. PMID: 17415036.
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    68. Zetola NM, Pilcher C. Diagnosis and management of acute HIV infection. Infect Dis Clin North Am. 2007 Mar; 21(1):19-48, vii. PMID: 17502228.
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    69. Priddy FH, Pilcher C, Moore RH, Tambe P, Park MN, Fiscus SA, Feinberg MB, del Rio C. Detection of acute HIV infections in an urban HIV counseling and testing population in the United States. J Acquir Immune Defic Syndr. 2007 Feb 01; 44(2):196-202. PMID: 17312561.
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    70. Hecht F, Pilcher C. Lessons from primary HIV infection. Focus. 2007 Feb; 22(2):1-5. PMID: 17549830.
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    71. Fiscus SA, Pilcher C, Miller WC, Powers KA, Hoffman IF, Price M, Chilongozi DA, Mapanje C, Krysiak R, Gama S, Martinson FE, Cohen MS. Rapid, real-time detection of acute HIV infection in patients in Africa. J Infect Dis. 2007 Feb 01; 195(3):416-24. PMID: 17205481.
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    72. Kilby JM, Bucy RP, Mildvan D, Fischl M, Santana-Bagur J, Lennox J, Pilcher C, Zolopa A, Lawrence J, Pollard RB, Habib RE, Sahner D, Fox L, Aga E, Bosch RJ, Mitsuyasu R. A randomized, partially blinded phase 2 trial of antiretroviral therapy, HIV-specific immunizations, and interleukin-2 cycles to promote efficient control of viral replication (ACTG A5024). J Infect Dis. 2006 Dec 15; 194(12):1672-6. PMID: 17109338.
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    73. Pilcher C, Eaton L, Kalichman S, Bisol C, de Souza Rda S. Approaching "HIV elimination": interventions for acute HIV infection. Curr HIV/AIDS Rep. 2006 Nov; 3(4):160-8. PMID: 17032575.
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    74. Gulick RM, Ribaudo HJ, Shikuma CM, Lalama C, Schackman BR, Meyer WA, Acosta EP, Schouten J, Squires KE, Pilcher C, Murphy RL, Koletar SL, Carlson M, Reichman RC, Bastow B, Klingman KL, Kuritzkes DR. Three- vs four-drug antiretroviral regimens for the initial treatment of HIV-1 infection: a randomized controlled trial. JAMA. 2006 Aug 16; 296(7):769-81. PMID: 16905783.
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    75. Pilcher C, Fiscus SA, Nguyen TQ, Foust E, Wolf L, Williams D, Ashby R, O'Dowd JO, McPherson JT, Stalzer B, Hightow L, Miller WC, Eron JJ, Cohen MS, Leone PA. Detection of acute infections during HIV testing in North Carolina. N Engl J Med. 2005 May 05; 352(18):1873-83. PMID: 15872202.
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    76. McDougal JS, Pilcher C, Parekh BS, Gershy-Damet G, Branson BM, Marsh K, Wiktor SZ. Surveillance for HIV-1 incidence using tests for recent infection in resource-constrained countries. AIDS. 2005 May; 19 Suppl 2:S25-30. PMID: 15930838.
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    77. Hightow LB, MacDonald PD, Pilcher C, Kaplan AH, Foust E, Nguyen TQ, Leone PA. The unexpected movement of the HIV epidemic in the Southeastern United States: transmission among college students. J Acquir Immune Defic Syndr. 2005 Apr 15; 38(5):531-7. PMID: 15793362.
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    78. Cohen MS, Pilcher C. Amplified HIV transmission and new approaches to HIV prevention. J Infect Dis. 2005 May 01; 191(9):1391-3. PMID: 15809893.
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    79. Ritola K, Pilcher C, Fiscus SA, Hoffman NG, Nelson JA, Kitrinos KM, Hicks CB, Eron JJ, Swanstrom R. Multiple V1/V2 env variants are frequently present during primary infection with human immunodeficiency virus type 1. J Virol. 2004 Oct; 78(20):11208-18. PMID: 15452240; PMCID: PMC521858.
    80. Gulick RM, Ribaudo HJ, Shikuma CM, Lustgarten S, Squires KE, Meyer WA, Acosta EP, Schackman BR, Pilcher C, Murphy RL, Maher WE, Witt MD, Reichman RC, Snyder S, Klingman KL, Kuritzkes DR. Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection. N Engl J Med. 2004 Apr 29; 350(18):1850-61. PMID: 15115831.
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    81. Pilcher C, Tien HC, Eron JJ, Vernazza PL, Leu SY, Stewart PW, Goh LE, Cohen MS. Brief but efficient: acute HIV infection and the sexual transmission of HIV. J Infect Dis. 2004 May 15; 189(10):1785-92. PMID: 15122514.
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    82. Pilcher C, Eron JJ, Galvin S, Gay C, Cohen MS. Acute HIV revisited: new opportunities for treatment and prevention. J Clin Invest. 2004 Apr; 113(7):937-45. PMID: 15057296; PMCID: PMC379335.
    83. Wohl DA, Pilcher C, Evans S, Revuelta M, McComsey G, Yang Y, Zackin R, Alston B, Welch S, Basar M, Kashuba A, Kondo P, Martinez A, Giardini J, Quinn J, Littles M, Wingfield H, Koletar SL. Absence of sustained hyperlactatemia in HIV-infected patients with risk factors for mitochondrial toxicity. J Acquir Immune Defic Syndr. 2004 Mar 01; 35(3):274-8. PMID: 15076242.
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    84. Donovan BJ, Rublein JC, Leone PA, Pilcher C. HIV infection: point-of-care testing. Ann Pharmacother. 2004 Apr; 38(4):670-6. PMID: 14990775.
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    85. Pilcher C, Price MA, Hoffman IF, Galvin S, Martinson FE, Kazembe PN, Eron JJ, Miller WC, Fiscus SA, Cohen MS. Frequent detection of acute primary HIV infection in men in Malawi. AIDS. 2004 Feb 20; 18(3):517-24. PMID: 15090805.
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    86. Freel SA, Fiscus SA, Pilcher C, Menezes P, Giner J, Patrick E, Lennox JL, Hicks CB, Eron JJ, Shugars DC. Envelope diversity, coreceptor usage and syncytium-inducing phenotype of HIV-1 variants in saliva and blood during primary infection. AIDS. 2003 Sep 26; 17(14):2025-33. PMID: 14502005.
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    87. Weintrob AC, Giner J, Menezes P, Patrick E, Benjamin DK, Lennox J, Pilcher C, Eron JJ, Hicks CB. Infrequent diagnosis of primary human immunodeficiency virus infection: missed opportunities in acute care settings. Arch Intern Med. 2003 Sep 22; 163(17):2097-100. PMID: 14504125.
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    88. Pilcher C, McPherson JT, Leone PA, Smurzynski M, Owen-O'Dowd J, Peace-Brewer AL, Harris J, Hicks CB, Eron JJ, Fiscus SA. Real-time, universal screening for acute HIV infection in a routine HIV counseling and testing population. JAMA. 2002 Jul 10; 288(2):216-21. PMID: 12095386.
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    89. Pilcher C, Wohl DA, Hicks CB. Diagnosing primary HIV infection. Ann Intern Med. 2002 Mar 19; 136(6):488-9; author reply 488-9. PMID: 11900505.
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    90. Garba ML, Pilcher C, Bingham AL, Eron J, Frelinger JA. HIV antigens can induce TGF-beta(1)-producing immunoregulatory CD8+ T cells. J Immunol. 2002 Mar 01; 168(5):2247-54. PMID: 11859112.
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    91. Pilcher C, Eron JJ, Vemazza PL, Battegay M, Harr T, Yerly S, Vom S, Perrin L. Sexual transmission during the incubation period of primary HIV infection. JAMA. 2001 Oct 10; 286(14):1713-4. PMID: 11594895.
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    92. Pilcher C, Shugars DC, Fiscus SA, Miller WC, Menezes P, Giner J, Dean B, Robertson K, Hart CE, Lennox JL, Eron JJ, Hicks CB. HIV in body fluids during primary HIV infection: implications for pathogenesis, treatment and public health. AIDS. 2001 May 04; 15(7):837-45. PMID: 11399956.
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    93. Pilcher C, Eron JJ, Ngo L, Dusek A, Sista P, Gleavy J, Brooks D, Venetta T, DiMassimo E, Hopkins S. Prolonged therapy with the fusion inhibitor T-20 in combination with oral antiretroviral agents in an HIV-infected individual. AIDS. 1999 Oct 22; 13(15):2171-3. PMID: 10546874.
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    94. Pilcher C, Miller WC, Beatty ZA, Eron JJ. Detectable HIV-1 RNA at levels below quantifiable limits by amplicor HIV-1 monitor is associated with virologic relapse on antiretroviral therapy. AIDS. 1999 Jul 30; 13(11):1337-42. PMID: 10449286.
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    95. Pilcher C, Perkins MD, Fiscus SA, Johnston DM, Dietze R, Duque UH, Zago AM, Assad-Antunes F, Eron JJ. Genotypic resistance and the treatment of HIV-1 infection in Espírito Santo, Brazil. J Infect Dis. 1999 May; 179(5):1259-63. PMID: 10191233.
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    96. Dyer JR, Pilcher C, Shepard R, Schock J, Eron JJ, Fiscus SA. Comparison of NucliSens and Roche Monitor assays for quantitation of levels of human immunodeficiency virus type 1 RNA in plasma. J Clin Microbiol. 1999 Feb; 37(2):447-9. PMID: 9889240; PMCID: PMC84337.
    97. Harrison TR, Calhoun JA, Cullen GE, Wilkins WE, Pilcher C. STUDIES IN CONGESTIVE HEART FAILURE: XV. Reflex Versus Chemical Factors in the Production of Rapid Breathing. J Clin Invest. 1932 Jan; 11(1):133-54. PMID: 16694024; PMCID: PMC435804.
    98. Pilcher C, Calhoun JA, Cullen GE, Harrison TR. STUDIES IN CONGESTIVE HEART FAILURE: V. The Potassium Content of Skeletal Muscle Obtained by Biopsy. J Clin Invest. 1930 Oct; 9(2):191-6. PMID: 16693926; PMCID: PMC435689.
    99. Harrison TR, Pilcher C, Ewing G. STUDIES IN CONGESTIVE HEART FAILURE: IV. The Potassium Content of Skeletal and Cardiac Muscle. J Clin Invest. 1930 Apr; 8(3):325-35. PMID: 16693898; PMCID: PMC424623.
    100. Pilcher C, Clark G, Harrison TR. STUDIES IN CONGESTIVE HEART FAILURE: III. The Buffering Power of the Blood and Tissues. J Clin Invest. 1930 Apr; 8(3):317-23. PMID: 16693897; PMCID: PMC424622.
    101. Harrison TR, Pilcher C. STUDIES IN CONGESTIVE HEART FAILURE: II. The Respiratory Exchange During and After Exercise. J Clin Invest. 1930 Apr; 8(3):291-315. PMID: 16693896; PMCID: PMC424621.
    102. Harrison TR, Pilcher C. STUDIES IN CONGESTIVE HEART FAILURE: I. The Effect of Edema on Oxygen Utilization. J Clin Invest. 1930 Feb; 8(2):259-90. PMID: 16693895; PMCID: PMC424620.
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