My long-term career goal is to optimize the health outcomes of infant and children living in resource limited settings. The current focus of my research is the optimization of treatment outcomes of children living with human immunodeficiency virus (HIV) infection. I serve as co-chair of the NIH/DHHS Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children that publishes treatment guidelines for children in the USA, and vice-chair to the Pediatric AIDS Working Group at the World Health Organization. Within the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT), I serve as Chair of the Treatment Scientific Committee and co-chair of P1093, a protocol establishing dosing and safety of Dolutegravir in children. I am also the principal investigator of the NICHD-funded study called The Treating Infants Early Study (TIES), which that enrolling infants who start treatment within the first weeks of life to look at safety, virologic decay, latent reservoir establishment. In Africa, I have been involved several trials looking that treatment of malaria and HIV in children, and now lead a cluster randomized trial of a multi-level intervention to improve outcomes in youth living with HIV in rural Kenya and Uganda. I continue to work broader issues of maternal child health through an NGO that I co-founded, now called Global Strategies.