Michelle Arkin, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address600 16th Street, #S512D
San Francisco CA 94158
Phone415-514-4313
PronounsShe/Her/Hers
ORCID ORCID Icon0000-0002-9366-6770 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Bryn Mawr College, Pennsylvania, USAAB06/1990Chemistry
    Caltech, California, USAPhD02/1997Chemistry
    Genentech, California, USA6/1998Protein Engineering
    Collapse Awards and Honors
    Bryn Mawr College1989Shippen Science Scholarship
    Bryn Mawr College1989Dorothy Nepper Marshall Fellowship
    Armed Force1989Armed Forces Communications and Electronics Association Scholarship
    Bryn Mawr College1990  - 1991European Traveling Fellowship
    General Electric Foundation1991  - 1992Blodgett Fellowship
    National Science Foundation 1992  - 1995Predoctoral Fellowship
    National Institutes of Health 1995  - 1997National Institutes of Health Traineeship
    Daymon Runyon – Walter Winchell Cancer Research Foundation 1997  - 1999Daymon Runyon – Walter Winchell Cancer Research Foundation Postdoctoral Fellowship
    SLAS2013Finalist, SLAS Innovation Award
    ONO Pharma Foundation2018  - 2021Breakthrough Chemical Biology Research Award
    American Chemical Society, Organic Division2024Cope Scholar Award
    American Chemical Society, Biological Division2024Gordon Hammes Lecture Award

    Collapse Overview 
    Collapse Overview
    Michelle’s lab develops innovative approaches to screen for chemical tools and drug leads, using biophysical approaches like fragment-based drug discovery and biological approaches including high-content imaging with primary cells and organisms. Our goal is to demonstrate ‘druggability’ of new target classes and to use our compounds to discover new targets for drug discovery. Areas of interest include protein-protein interactions, allosteric and scaffolding sites in enzymes, and orphan and neglected diseases. Michelle is co-Director of the Small Molecule Discovery Center, a collaborative research and core lab that includes a high-throughput screening facility and medicinal chemistry (smdc.ucsf.edu).

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death. Mol Cell Neurosci. 2024 Jul 20; 130:103954. Theofilas P, Wang C, Butler D, Morales DO, Petersen C, Ambrose A, Chin B, Yang T, Khan S, Ng R, Kayed R, Karch CM, Miller BL, Gestwicki JE, Gan L, Temple S, Arkin MR, Grinberg LT. PMID: 39032719.
      View in: PubMed   Mentions:    Fields:    
    2. 14-3-3 Protein-Protein Interactions: From Mechanistic Understanding to Their Small-Molecule Stabilization. Chembiochem. 2024 Jul 15; 25(14):e202400214. Somsen BA, Cossar PJ, Arkin MR, Brunsveld L, Ottmann C. PMID: 38738787.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues. SLAS Discov. 2024 Jul; 29(5):100165. Vickery HR, Virta JM, Konstantinidou M, Arkin MR. PMID: 38797286.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants. Am J Hum Genet. 2024 06 06; 111(6):1222-1238. Silva DB, Trinidad M, Ljungdahl A, Revalde JL, Berguig GY, Wallace W, Patrick CS, Bomba L, Arkin M, Dong S, Estrada K, Hutchinson K, LeBowitz JH, Schlessinger A, Johannesen KM, Møller RS, Giacomini KM, Froelich S, Sanders SJ, Wuster A. PMID: 38781976; PMCID: PMC11179425.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Molecular glues for protein-protein interactions: Progressing toward a new dream. Cell Chem Biol. 2024 Jun 20; 31(6):1064-1088. Konstantinidou M, Arkin MR. PMID: 38701786; PMCID: PMC11193649.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Anal Chem. 2024 04 02; 96(13):5223-5231. D'Ippolito RA, Rabara D, Blanco MA, Alberico E, Drew MR, Ramakrishnan N, Sontan D, Widmeyer SRT, Scheidemantle GM, Messing S, Turner D, Arkin M, Maciag AE, Stephen AG, Esposito D, McCormick F, Nissley DV, DeHart CJ. PMID: 38498381; PMCID: PMC10993199.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    7. An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis. J Clin Invest. 2024 Mar 07; 134(9). Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, Tsukui T, Sheppard D, Arkin MR, Peng T. PMID: 38451724; PMCID: PMC11060735.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Synthetic autophagy receptor. Autophagy. 2024 Mar; 20(3):701-703. Jiang Z, Kuo YH, Arkin MR. PMID: 37934826; PMCID: PMC10936620.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    9. Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening. RSC Chem Biol. 2024 Mar 06; 5(3):209-215. Ortiz G, Longbotham JE, Qin SL, Zhang MY, Lee GM, Neitz RJ, Kelly MJS, Arkin MR, Fujimori DG. PMID: 38456036; PMCID: PMC10915964.
      View in: PubMed   Mentions:
    10. The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nat Struct Mol Biol. 2023 Dec; 30(12):2009-2019. Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR. PMID: 37945741; PMCID: PMC10716044.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation. J Am Chem Soc. 2023 11 08; 145(44):23939-23947. Jiang Z, Kuo YH, Arkin MR. PMID: 37748140; PMCID: PMC10636752.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments. J Am Chem Soc. 2023 09 20; 145(37):20328-20343. Konstantinidou M, Visser EJ, Vandenboorn E, Chen S, Jaishankar P, Overmans M, Dutta S, Neitz RJ, Renslo AR, Ottmann C, Brunsveld L, Arkin MR. PMID: 37676236; PMCID: PMC10515640.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking. Angew Chem Int Ed Engl. 2023 09 11; 62(37):e202308004. Visser EJ, Jaishankar P, Sijbesma E, Pennings MAM, Vandenboorn EMF, Guillory X, Neitz RJ, Morrow J, Dutta S, Renslo AR, Brunsveld L, Arkin MR, Ottmann C. PMID: 37455289; PMCID: PMC11287480.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    14. From tethered to freestanding stabilizers of 14-3-3 protein-protein interactions via fragment linking. Angewandte Chemie. 2023 Aug 1. Visser VE, Jaishankar JP, Sijbesma SE, Pennings PM, Vandenboorn VE, Guillory GX, Neitz NR, Morrow MJ, Dutta DS, Renslo RA, Brunsveld BL, Arkin AM, Ottmann OC. .
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    15. Systematic Study of Heteroarene Stacking Using a Congeneric Set of Molecular Glues for Procaspase-6. J Med Chem. 2023 07 27; 66(14):9784-9796. Togo T, Tram L, Denton LG, ElHilali-Pollard X, Gu J, Jiang J, Liu C, Zhao Y, Zhao Y, Zheng Y, Zheng Y, Yang J, Fan P, Arkin MR, Härmä H, Sun D, Canan SS, Wheeler SE, Renslo AR. PMID: 37406165; PMCID: PMC10388292.
      View in: PubMed   Mentions:    Fields:    
    16. The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. bioRxiv. 2023 May 15. Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR. PMID: 37292947; PMCID: PMC10245715.
      View in: PubMed   Mentions:
    17. Venetoclax and dinaciclib elicit synergistic preclinical efficacy against hypodiploid acute lymphoblastic leukemia. Haematologica. 2023 05 01; 108(5):1272-1283. Pariury H, Fandel J, Bachl S, Ang KK, Markossian S, Wilson CG, Braun BS, Popescu B, Wohlfeil M, Beckman K, Xirenayi S, Roy RP, Olshen AB, Smith C, Arkin MR, Loh ML, Diaz-Flores E. PMID: 36700399; PMCID: PMC10153511.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol. 2023 06 15; 30(6):573-590.e6. Andlovic B, Heilmann G, Ninck S, Andrei SA, Centorrino F, Higuchi Y, Kato N, Brunsveld L, Arkin M, Menninger S, Choidas A, Wolf A, Klebl B, Kaschani F, Kaiser M, Eickhoff J, Ottmann C. PMID: 37130519.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Abstract A018: A top-down proteomic assay to evaluate KRAS4B-compound engagement. Molecular Cancer Research. 2023 May 1; 21(5_Supplement):a018-a018. D'Ippolito DR, DeHart DC, Rabara RD, Blanco BM, Alberico AE, Ramakrishnan RN, Widmeyer WS, Messing MS, Turner TD, Arkin AM, Maciag MA, Stephen SA, Esposito ED, McCormick MF, Nissley ND. .
      View in: Publisher Site   Mentions:
    20. Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. J Am Chem Soc. 2023 05 10; 145(18):10015-10021. Van Horn KS, Wang D, Medina-Cleghorn D, Lee PS, Bryant C, Altobelli C, Jaishankar P, Leung KK, Ng RA, Ambrose AJ, Tang Y, Arkin MR, Renslo AR. PMID: 37104712; PMCID: PMC10176470.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. ACS Cent Sci. 2023 May 24; 9(5):937-946. Kenanova DN, Visser EJ, Virta JM, Sijbesma E, Centorrino F, Vickery HR, Zhong M, Neitz RJ, Brunsveld L, Ottmann C, Arkin MR. PMID: 37252362; PMCID: PMC10214524.
      View in: PubMed   Mentions: 3  
    22. Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach. J Am Chem Soc. 2023 03 29; 145(12):6741-6752. Somsen BA, Schellekens RJC, Verhoef CJA, Arkin MR, Ottmann C, Cossar PJ, Brunsveld L. PMID: 36926879; PMCID: PMC10064330.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency. Proc Natl Acad Sci U S A. 2022 Nov 16; 119(46):e2210247119. Koleske ML, McInnes G, Brown JEH, Thomas N, Hutchinson K, Chin MY, Koehl A, Arkin MR, Schlessinger A, Gallagher RC, Song YS, Altman RB, Giacomini KM. PMID: 36343260; PMCID: PMC9674959.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    24. LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface. Biochemistry. 2022 11 01; 61(21):2295-2302. Tang Y, Kay A, Jiang Z, Arkin MR. PMID: 36264309; PMCID: PMC9631991.
      View in: PubMed   Mentions: 1     Fields:    
    25. Abstract B004: ATR-CHK1-WEE1 pathway is a critical dependency in the context of DNA damage and replicative stress in osteosarcoma. Clinical Cancer Research. 2022 Sep 15; 28(18_Supplement):b004-b004. Sayles SL, Martell MH, Koehne KA, Ang AK, Wilson WC, Arkin AM, Sweet-Cordero SE. .
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    26. Cryo-EM structures reveal dramatic remodeling of the p97 hexamer by the multi-domain adapter UBXD1. Acta Crystallographica Section A: Foundations and advances. 2022 Jul 29; 78(a1):a202-a202. Braxton BJ, Altobelli AC, Arkin AM, Southworth SD. .
      View in: Publisher Site   Mentions:
    27. Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein-Protein Interactions. J Am Chem Soc. 2022 07 27; 144(29):13218-13225. Jiang Z, Kuo YH, Zhong M, Zhang J, Zhou XX, Xing L, Wells JA, Wang Y, Arkin MR. PMID: 35819848; PMCID: PMC9335864.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    28. Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: Diagnostic and therapeutic implications. Neuropathol Appl Neurobiol. 2022 08; 48(5):e12819. Theofilas P, Piergies AMH, Oh I, Lee YB, Li SH, Pereira FL, Petersen C, Ehrenberg AJ, Eser RA, Ambrose AJ, Chin B, Yang T, Khan S, Ng R, Spina S, Seeley WW, Miller BL, Arkin MR, Grinberg LT. PMID: 35508761; PMCID: PMC9472770.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    29. Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model. ACS Chem Neurosci. 2022 05 18; 13(10):1505-1516. Chin MY, Ang KH, Davies J, Alquezar C, Garda VG, Rooney B, Leng K, Kampmann M, Arkin MR, Kao AW. PMID: 35522480; PMCID: PMC9121341.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    30. Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine. Cell Chem Biol. 2022 05 19; 29(5):785-798.e19. Hulce KR, Jaishankar P, Lee GM, Bohn MF, Connelly EJ, Wucherer K, Ongpipattanakul C, Volk RF, Chuo SW, Arkin MR, Renslo AR, Craik CS. PMID: 35364007; PMCID: PMC9133232.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. In Vivo Dopamine Neuron Imaging-Based Small Molecule Screen Identifies Novel Neuroprotective Compounds and Targets. Front Pharmacol. 2022; 13:837756. Kim GJ, Mo H, Liu H, Okorie M, Chen S, Zheng J, Li H, Arkin M, Huang B, Guo S. PMID: 35370735; PMCID: PMC8971663.
      View in: PubMed   Mentions: 3  
    32. Caspase-6-cleaved tau is relevant in Alzheimer's disease but not in 4-repeat tauopathies: Diagnostic and therapeutic implications. Alzheimer's & Dementia. 2022 Feb 1; 17. Piergies PA, Theofilas TP, Li LS, Petersen PC, Ehrenberg EA, Eser ER, Chin CB, Yang YT, Khan KS, Ng NR, Spina SS, Seeley SW, Miller MB, Arkin AM, Grinberg GL. .
      View in: Publisher Site   Mentions:
    33. Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation. Alzheimer's & Dementia. 2021 Dec 1; 17(S3). Theofilas TP, Ambrose AA, Butler BD, Wang WC, Morales MD, Petersen PC, Chin CB, Yang YT, Khan KS, Ng NR, Kayed KR, Karch KC, Miller MB, Gestwicki GJ, Gan GL, Temple TS, Arkin AM, Grinberg GL. .
      View in: Publisher Site   Mentions:
    34. A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. Elife. 2021 09 22; 10. Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S. PMID: 34550070; PMCID: PMC8457844.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    35. Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH. ACS Sens. 2021 06 25; 6(6):2168-2180. Chin MY, Patwardhan AR, Ang KH, Wang AL, Alquezar C, Welch M, Nguyen PT, Grabe M, Molofsky AV, Arkin MR, Kao AW. PMID: 34102054; PMCID: PMC8240087.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    36. Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. ACS Med Chem Lett. 2021 Jun 10; 12(6):976-982. Sijbesma E, Hallenbeck KK, Andrei SA, Rust RR, Adriaans JMC, Brunsveld L, Arkin MR, Ottmann C. PMID: 34136078; PMCID: PMC8201753.
      View in: PubMed   Mentions: 6  
    37. Real-Time Assessment of Mitochondrial Toxicity in HepG2 Cells Using the Seahorse Extracellular Flux Analyzer. Curr Protoc. 2021 Mar; 1(3):e75. Espinosa JA, Pohan G, Arkin MR, Markossian S. PMID: 33735523.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. Reimagining dots and dashes: Visualizing structure and function of organelles for high-content imaging analysis. Cell Chem Biol. 2021 03 18; 28(3):320-337. Chin MY, Espinosa JA, Pohan G, Markossian S, Arkin MR. PMID: 33600764; PMCID: PMC7995685.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    39. An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease. Pathogens. 2021 Jan 14; 10(1). Tyagi R, Bulman CA, Cho-Ngwa F, Fischer C, Marcellino C, Arkin MR, McKerrow JH, McNamara CW, Mahoney M, Tricoche N, Jawahar S, Janetka JW, Lustigman S, Sakanari J, Mitreva M. PMID: 33466870; PMCID: PMC7830784.
      View in: PubMed   Mentions: 7  
    40. A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery. Commun Biol. 2020 12 21; 3(1):747. Chen S, Suzuki BM, Dohrmann J, Singh R, Arkin MR, Caffrey CR. PMID: 33349640; PMCID: PMC7752906.
      View in: PubMed   Mentions: 9  Translation:Animals
    41. Caspase-6-mediated tau cleavage and pathology in Alzheimer’s disease and other tauopathies. Alzheimer's & Dementia. 2020 Dec 7; 16(S3). Piergies PA, Theofilas TP, Petersen PC, Ehrenberg EA, Li LS, Morales MD, Eser ER, Yang YT, Khan KS, Chin CB, Ng NR, Arkin AM, Grinberg GL. .
      View in: Publisher Site   Mentions:
    42. Multiparametric High-Content Assays to Measure Cell Health and Oxidative Damage as a Model for Drug-Induced Liver Injury. Curr Protoc Chem Biol. 2020 12; 12(4):e90. Pohan G, Espinosa JA, Chen S, Ang KK, Arkin MR, Markossian S. PMID: 33315311; PMCID: PMC8269189.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    43. Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers. ACS Chem Biol. 2020 12 18; 15(12):3143-3148. Sijbesma E, Somsen BA, Miley GP, Leijten-van de Gevel IA, Brunsveld L, Arkin MR, Ottmann C. PMID: 33196173; PMCID: PMC7754187.
      View in: PubMed   Mentions: 15     Fields:    
    44. Expression and purification of active human kinases using Pichia pastoris as a general-purpose host. Protein Expr Purif. 2021 03; 179:105780. Abdel Aziz MH, Fan Y, Liu L, Moasser MM, Fu H, Jura N, Arkin MR. PMID: 33115654.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    45. Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 Sep; 21(9):1135. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Coronado PER, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32661365.
      View in: PubMed   Mentions: 2     Fields:    
    46. High-Throughput Screening: today's biochemical and cell-based approaches. Drug Discov Today. 2020 10; 25(10):1807-1821. Blay V, Tolani B, Ho SP, Arkin MR. PMID: 32801051.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    47. Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex. ACS Chem Biol. 2020 08 21; 15(8):2041-2047. Leandro J, Khamrui S, Wang H, Suebsuwong C, Nemeria NS, Huynh K, Moustakim M, Secor C, Wang M, Dodatko T, Stauffer B, Wilson CG, Yu C, Arkin MR, Jordan F, Sanchez R, DeVita RJ, Lazarus MB, Houten SM. PMID: 32633484; PMCID: PMC7890914.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    48. Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J Med Chem. 2020 07 09; 63(13):6694-6707. Guillory X, Wolter M, Leysen S, Neves JF, Kuusk A, Genet S, Somsen B, Morrow JK, Rivers E, van Beek L, Patel J, Goodnow R, Schoenherr H, Fuller N, Cao Q, Doveston RG, Brunsveld L, Arkin MR, Castaldi P, Boyd H, Landrieu I, Chen H, Ottmann C. PMID: 32501690; PMCID: PMC7356319.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    49. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 05; 21(5):513-524. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32284594; PMCID: PMC7523413.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    50. Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. G3 (Bethesda). 2020 02 06; 10(2):849-862. Zhang P, Zhai Y, Cregg J, Ang KK, Arkin M, Kenyon C. PMID: 31879284; PMCID: PMC7003076.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    51. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. Mol Neurodegener. 2020 01 06; 15(1):2. Chen X, Li Y, Wang C, Tang Y, Mok SA, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL, Gestwicki JE, Arkin M, Cuervo AM, Gan L. PMID: 31906970; PMCID: PMC6945522.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    52. Chapter 5 Screening and biophysics in small molecule discovery. . 2020 Jan 1; 127-161. Wilson WC, Arkin AM. .
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    53. Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening. PLoS One. 2019; 14(12):e0226270. Sanchez MI, de Vries LE, Lehmann C, Lee JT, Ang KK, Wilson C, Chen S, Arkin MR, Bogyo M, Deu E. PMID: 31851699; PMCID: PMC6919601.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    54. A Cell-Based Renilla Luminescence Reporter Plasmid Assay for High-Throughput Screening to Identify Novel FDA-Approved Drug Inhibitors of HPV-16 Infection. SLAS Discov. 2020 01; 25(1):79-86. Walhart T, Isaacson-Wechsler E, Ang KH, Arkin M, Tugizov S, Palefsky JM. PMID: 31361520; PMCID: PMC6925341.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    55. Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat Chem Biol. 2019 08; 15(8):786-794. Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE. PMID: 31320752; PMCID: PMC6693490.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    56. TAU-MEDIATED CELL DEATH MECHANISMS IN MAPT V337M IPSC-DERIVED HUMAN NEURONS. Alzheimer's & Dementia. 2019 Jul 1; 15(7):p1006. Theofilas TP, Hayath HM, Wang WC, Butler BD, McAllen MS, Arkin AM, Gestwicki GJ, Cuervo CA, Kayed KR, Karch KC, Temple TS, Gan GL, Grinberg GL. .
      View in: Publisher Site   Mentions:
    57. Modulating protein-protein interaction networks in protein homeostasis. Curr Opin Chem Biol. 2019 06; 50:55-65. Zhong M, Lee GM, Sijbesma E, Ottmann C, Arkin MR. PMID: 30913483; PMCID: PMC6609442.
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    58. Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers. J Am Chem Soc. 2019 02 27; 141(8):3524-3531. Sijbesma E, Hallenbeck KK, Leysen S, de Vink PJ, Skóra L, Jahnke W, Brunsveld L, Arkin MR, Ottmann C. PMID: 30707565.
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    59. Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes. Microb Cell. 2019 Jan 07; 6(1):65-101. Klein HL, Ang KKH, Arkin MR, Beckwitt EC, Chang YH, Fan J, Kwon Y, Morten MJ, Mukherjee S, Pambos OJ, El Sayyed H, Thrall ES, Vieira-da-Rocha JP, Wang Q, Wang S, Yeh HY, Biteen JS, Chi P, Heyer WD, Kapanidis AN, Loparo JJ, Strick TR, Sung P, Van Houten B, Niu H, Rothenberg E. PMID: 30652106; PMCID: PMC6334232.
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    60. Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris. mBio. 2018 10 30; 9(5). Laurie MT, White CV, Retallack H, Wu W, Moser MS, Sakanari JA, Ang K, Wilson C, Arkin MR, DeRisi JL. PMID: 30377287; PMCID: PMC6212833.
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    61. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 11; 19(11):1212-1223. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. PMID: 30323343; PMCID: PMC6317891.
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    62. Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97. ACS Med Chem Lett. 2018 Nov 08; 9(11):1075-1081. LaPorte MG, Burnett JC, Colombo R, Bulfer SL, Alverez C, Chou TF, Neitz RJ, Green N, Moore WJ, Yue Z, Li S, Arkin MR, Wipf P, Huryn DM. PMID: 30429948; PMCID: PMC6231190.
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    63. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Endocrinology. 2018 09 01; 159(9):3321-3330. Lee J, Pappalardo Z, Chopra DG, Hennings TG, Vaughn I, Lan C, Choe JJ, Ang K, Chen S, Arkin M, McManus MT, German MS, Ku GM. PMID: 30059978; PMCID: PMC6112596.
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    64. Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development. Dis Model Mech. 2018 07 30; 11(7). El-Sakkary N, Chen S, Arkin MR, Caffrey CR, Ribeiro P. PMID: 29925529; PMCID: PMC6078403.
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    65. Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clin Transl Sci. 2018 09; 11(5):461-470. Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, Weidner JR, Riss T, Trask OJ, Auld D, Dahlin JL, Devanaryan V, Foley TL, McGee J, Kahl SD, Kales SC, Arkin M, Baell J, Bejcek B, Gal-Edd N, Glicksman M, Haas JV, Iversen PW, Hoeppner M, Lathrop S, Sayers E, Liu H, Trawick B, McVey J, Lemmon VP, Li Z, McManus O, Minor L, Napper A, Wildey MJ, Pacifici R, Chin WW, Xia M, Xu X, Lal-Nag M, Hall MD, Michael S, Inglese J, Simeonov A, Austin CP. PMID: 29877628; PMCID: PMC6132369.
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    66. Abstract SY23-03: Development and mechanistic characterization of USP7 deubiquitinase inhibitors. Cancer Research. 2018 Jul 1; 78(13_Supplement):sy23-03-sy23-03. Wertz WI, Kategaya KL, Lello LP, Rouge RL, Pastor PR, Clark CK, Drummond DJ, Kleinheinz KT, Lin LE, Upton UJ, Prakash PS, Heideker HJ, McCleland MM, Ritorto RM, Alessi AD, Trost TM, Bainbridge BT, Kwok KM, Ma MT, Stiffler SZ, Brasher BB, Tang TY, Jaishanker JP, Hearn HB, Renslo RA, Arkin AM, Cohen CF, Yu YK, Peale PF, Gnad GF, Chang CM, Klijn KC, Blackwood BE, Martin MS, Forrest FW, Ernst EJ, Ndubaku NC, Wang WX, Beresini BM, Tsui TV, Schwerdtfeger SC, Blake BR, Murray MJ, Maurer MT. .
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    67. Small-Molecule Screening for Genetic Diseases. Annu Rev Genomics Hum Genet. 2018 08 31; 19:263-288. Markossian S, Ang KK, Wilson CG, Arkin MR. PMID: 29799800.
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    68. EXTH-55. REPURPOSING THERAPEUTICS IN PATIENT-DERIVED GLIOMAS AND AN IDH1 MUTANT GLIOMA MODEL. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi84-vi85. Schmidt SC, Chen CS, IIkhanizadeh IS, Sabelstrom SH, Yuan YE, Ding DA, Weiss WW, Berger BM, Arkin AM, Persson PA. .
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    69. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 10 26; 550(7677):534-538. Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, Bainbridge TW, Kwok MCM, Ma TP, Stiffler Z, Brasher B, Tang Y, Jaishankar P, Hearn BR, Renslo AR, Arkin MR, Cohen F, Yu K, Peale F, Gnad F, Chang MT, Klijn C, Blackwood E, Martin SE, Forrest WF, Ernst JA, Ndubaku C, Wang X, Beresini MH, Tsui V, Schwerdtfeger C, Blake RA, Murray J, Maurer T, Wertz IE. PMID: 29045385.
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    70. A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments. SLAS Discov. 2018 02; 23(2):183-192. Hallenbeck KK, Davies JL, Merron C, Ogden P, Sijbesma E, Ottmann C, Renslo AR, Wilson C, Arkin MR. PMID: 28945980; PMCID: PMC6609441.
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    71. Chemical Biology as a Driver of Innovation in Cancer Research and Drug Discovery. Cell Chem Biol. 2017 09 21; 24(9):1057. Kostic M, Arkin M. PMID: 28938086.
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    72. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiol Aging. 2018 01; 61:1-12. Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. PMID: 29031088; PMCID: PMC5705284.
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    73. Applying Biophysical and Biochemical Methods to the Discovery of Allosteric Modulators of the AAA ATPase p97. Applied Biophysics for Drug Discovery. 2017 Aug 10; 217-240. Bulfer BS, Arkin AM. .
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    74. Joining Forces: The Chemical Biology-Medicinal Chemistry Continuum. Cell Chem Biol. 2017 Sep 21; 24(9):1058-1065. Plowright AT, Ottmann C, Arkin M, Auberson YP, Timmerman H, Waldmann H. PMID: 28602761.
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    75. High-Throughput Screening To Identify Potent and Specific Inhibitors of Microbial Sulfate Reduction. Environ Sci Technol. 2017 Jun 20; 51(12):7278-7285. Carlson HK, Mullan MR, Mosqueda LA, Chen S, Arkin MR, Coates JD. PMID: 28492331.
      View in: PubMed   Mentions: 4     Fields:    Translation:CellsPHPublic Health
    76. A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site. Org Biomol Chem. 2017 May 16; 15(19):4096-4114. Burnett JC, Lim C, Peyser BD, Samankumara LP, Kovaliov M, Colombo R, Bulfer SL, LaPorte MG, Hermone AR, McGrath CF, Arkin MR, Gussio R, Huryn DM, Wipf P. PMID: 28352916; PMCID: PMC5472064.
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    77. A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. Diabetes. 2017 06; 66(6):1703-1712. Pappalardo Z, Gambhir Chopra D, Hennings TG, Richards H, Choe J, Yang K, Baeyens L, Ang K, Chen S, Arkin M, German MS, McManus MT, Ku GM. PMID: 28246293; PMCID: PMC5440024.
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    78. Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery. Curr Top Med Chem. 2017; 17(1):4-15. Hallenbeck KK, Turner DM, Renslo AR, Arkin MR. PMID: 27449257; PMCID: PMC5321175.
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    79. Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen. SLAS Discov. 2017 03; 22(3):324-331. Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J. PMID: 27932698; PMCID: PMC5491343.
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    80. A High-Content Larval Zebrafish Brain Imaging Method for Small Molecule Drug Discovery. PLoS One. 2016; 11(10):e0164645. Liu H, Chen S, Huang K, Kim J, Mo H, Iovine R, Gendre J, Pascal P, Li Q, Sun Y, Dong Z, Arkin M, Guo S, Huang B. PMID: 27732643; PMCID: PMC5061318.
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    81. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. Elife. 2016 07 20; 5. Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. PMID: 27435960; PMCID: PMC4954757.
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    82. p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions. ACS Chem Biol. 2016 08 19; 11(8):2112-6. Bulfer SL, Chou TF, Arkin MR. PMID: 27267671; PMCID: PMC5224236.
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    83. Challenges and solutions to developing an automated high-throughput/high-content screening platform for the ‘neglected’ schistosome parasite. The FASEB Journal. 2016 Apr 1; 30(S1). Caffrey CC, Chen CS, Suzuki SB, Singh SR, Arkin AM. .
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    84. 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science. 2016 Feb 19; 351(6275):871-5. Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, Subramaniam S. PMID: 26822609; PMCID: PMC6946184.
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    85. Making FBDD Work in Academia. Fragment-based Drug Discovery Lessons and Outlook. 2016 Jan 11; 223-246. Bulfer BS, Jean-Francois JF, Arkin AM. .
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    86. Interview with Michelle Arkin, PhD. Assay Drug Dev Technol. 2016 Jan-Feb; 14(1):14-8. Arkin M. PMID: 26866749.
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    87. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. ACS Med Chem Lett. 2016 Feb 11; 7(2):182-7. Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, Arkin MR, Wipf P, Huryn DM. PMID: 26985295; PMCID: PMC4753542.
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    88. A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. Elife. 2015 Dec 11; 4. Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. PMID: 26653140; PMCID: PMC4749390.
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    89. Covalent targeting of acquired cysteines in cancer. Curr Opin Chem Biol. 2016 Feb; 30:61-67. Visscher M, Arkin MR, Dansen TB. PMID: 26629855; PMCID: PMC4731306.
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    90. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. ACS Med Chem Lett. 2015 Dec 10; 6(12):1225-30. Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, LaPorte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. PMID: 26713109; PMCID: PMC4677369.
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    91. Tackling reproducibility in academic preclinical drug discovery. Nat Rev Drug Discov. 2015 11; 14(11):733-4. Frye SV, Arkin MR, Arrowsmith CH, Conn PJ, Glicksman MA, Hull-Ryde EA, Slusher BS. PMID: 26388229.
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    92. Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease. PLoS Pathog. 2015 Jul; 11(7):e1005058. Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, Glynne RJ, Supek F. PMID: 26186534; PMCID: PMC4506092.
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    93. Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. PLoS Negl Trop Dis. 2015; 9(6):e0003878. Ekins S, de Siqueira-Neto JL, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C. PMID: 26114876; PMCID: PMC4482694.
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    94. Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4834-4837. Neitz RJ, Bryant C, Chen S, Gut J, Hugo Caselli E, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR. PMID: 26144347; PMCID: PMC4737481.
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    95. Altered cofactor regulation with disease-associated p97/VCP mutations. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):E1705-14. Zhang X, Gui L, Zhang X, Bulfer SL, Sanghez V, Wong DE, Lee Y, Lehmann L, Lee JS, Shih PY, Lin HJ, Iacovino M, Weihl CC, Arkin MR, Wang Y, Chou TF. PMID: 25775548; PMCID: PMC4394316.
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    96. Tethering in RNA: an RNA-binding fragment discovery tool. Molecules. 2015 Mar 04; 20(3):4148-61. Tran K, Arkin MR, Beal PA. PMID: 25749683; PMCID: PMC4760646.
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    97. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. PMID: 25700363; PMCID: PMC4336141.
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    98. A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP. J Biomol Screen. 2015 Jul; 20(6):788-800. Chimenti MS, Bulfer SL, Neitz RJ, Renslo AR, Jacobson MP, James TL, Arkin MR, Kelly MJ. PMID: 25690569.
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    99. Biophysical methods for identifying fragment-based inhibitors of protein-protein interactions. Methods Mol Biol. 2015; 1278:587-613. Pfaff SJ, Chimenti MS, Kelly MJ, Arkin MR. PMID: 25859978.
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    100. Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem J. 2015 Jan 01; 465(1):149-61. Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J. PMID: 25287889; PMCID: PMC4410814.
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    101. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18590-5. Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. PMID: 25518860; PMCID: PMC4284534.
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    102. Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015 Jan; 20(1):101-11. Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. PMID: 25281737.
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    103. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. Chem Biol. 2014 Sep 18; 21(9):1102-14. Arkin MR, Tang Y, Wells JA. PMID: 25237857; PMCID: PMC4179228.
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    104. Screening for noise in gene expression identifies drug synergies. Science. 2014 Jun 20; 344(6190):1392-6. Dar RD, Hosmane NN, Arkin MR, Siliciano RF, Weinberger LS. PMID: 24903562; PMCID: PMC4122234.
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    105. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. J Mol Biol. 2014 Jul 29; 426(15):2886-99. Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR. PMID: 24878061; PMCID: PMC4102644.
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    106. UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area. Comb Chem High Throughput Screen. 2014 May; 17(4):333-42. Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. PMID: 24661212.
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    107. Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases. Curr Top Med Chem. 2014; 14(3):319-25. Flygare JA, Arkin MR. PMID: 24283214.
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    108. Inside Cover: Tailoring Small Molecules for an Allosteric Site on Procaspase-6 (ChemMedChem 1/2014). ChemMedChem. 2014 Jan 1; 9(1):2-2. Murray MJ, Giannetti GA, Steffek SM, Gibbons GP, Hearn HB, Cohen CF, Tam TC, Pozniak PC, Bravo BB, Lewcock LJ, Jaishankar JP, Ly LC, Zhao ZX, Tang TY, Chugha CP, Arkin AM, Flygare FJ, Renslo RA. .
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    109. Probing structural adaptivity at PPI interfaces with small molecules. Drug Discov Today Technol. 2013 Dec; 10(4):e501-8. Wilson CG, Arkin MR. PMID: 24451641.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    110. Tailoring small molecules for an allosteric site on procaspase-6. ChemMedChem. 2014 Jan; 9(1):73-7, 2. Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. PMID: 24259468.
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    111. Bringing together the academic drug discovery community. Nat Rev Drug Discov. 2013 Nov; 12(11):811-2. Slusher BS, Conn PJ, Frye S, Glicksman M, Arkin M. PMID: 24172316; PMCID: PMC4076044.
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    112. Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife. 2013 Sep 10; 2:e00508. Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S. PMID: 24040509; PMCID: PMC3771564.
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    113. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16; 8(8):1841-51. Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL. PMID: 23738709; PMCID: PMC3747594.
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    114. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28; 2:e00498. Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. PMID: 23741617; PMCID: PMC3667625.
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    115. Abstract 5524: Library screen to rapidly determine activity against normal and mutant bone marrow progenitor cells. Cancer Research. 2013 Apr 15; 73(8_Supplement):5524-5524. Hong HW, Akutagawa AJ, Chen CS, Arkin AM, Braun BB. .
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    116. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein J Org Chem. 2013; 9:15-25. Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. PMID: 23400640; PMCID: PMC3566858.
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    117. Protein–Protein Interactions – Inhibition. Encyclopedia of Biophysics. 2013 Jan 1; 2093-2098. Chugha CP, Arkin AM. .
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    118. P2X Receptors for ATP: Molecular Properties and Functional Roles. . 2013 Jan 1; 1819-1824. Evans ER, Bertini BI, Parigi PG, Davies DN, Morris MV, van der Kamp vM, Nagayama NK, Koynova KR, Tenchov TB, van der Kamp vM, Nath NA, Rhoades RE, van der Kamp vM, Biteen BJ, Bizzarri BR, Tang TK, Blankenship BR, Grotjohann GI, Fromme FP, McConnell MI, Brudvig BG, Yang YX, Matthews MJ, Marsh MD, Rodger RA, Rahmani RB, Ghanbari GH, Tzamtzis TS, Burriesci BG, Seifalian SA, Kipper KM, Harding HS, Jones JT, Coulson-Thomas CV, Gesteira GT, Coulson-Thomas CY, Nader NH, Lehtomaki LE, Mackay MJ, Bernèche BS, Yang YS, Jan JL, Yunus YS, Jonas JA, Lakard LB, Winter WR, Winter WR, Friedler FA, Katz KC, Whitmore WL, Janes JR, Hirst HJ, Matthews MJ, Rodger RA, Akke AM, Lundström LP, Gilardi GG, Lee LA, Kear KJ, Fanucci FG, van der Kamp vM, Skoff SD, Zanni ZM, Callender CR, Dyer DR, Pande PV, Towse TC, Daggett DV, van der Kamp vM, Roberts RG, Inagaki IF, Ellis EJ, Kobe KB, Kloppmann KE, Hoenigschmid HP, Rost RB, Eryilmaz EE, Liu LD, Cowburn CD, Mujika MJ, Lopez LX, Tramontano TA, Sadowski SM, Roche RD, Buenavista BM, McGuffin ML, Sadowski SM, Rodnina RM, Peng PJ, Wilkins WM, Sokratous SK, Afonso AJ, Chugha CP, Arkin AM, Schreiber SG, Lesk LA, Mulloy MB, Warren WJ, Mayer MJ, García-Rubio GI, García-Rubio GI, Chary CK, Srivastava SA, Schwartz SC, Zhang ZH, Guo GP, Hille HR. .
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    119. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. PLoS One. 2012; 7(12):e50864. Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR. PMID: 23227217; PMCID: PMC3515450.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    120. An In Vitro Library Screen to Rapidly Determine Activity Against Normal and Mutant Bone Marrow Progenitor Cells. Blood. 2012 Nov 16; 120(21):4916-4916. Hong HW, Chen CS, Akutagawa AJ, Arkin AM, Braun BB. .
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    121. Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13644-9. Wu VM, Chen SC, Arkin MR, Reiter JF. PMID: 22864913; PMCID: PMC3427101.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    122. Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis. 2012; 6(7):e1736. Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. PMID: 22860142; PMCID: PMC3409115.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    123. Analysis of high-throughput screening assays using cluster enrichment. Stat Med. 2012 Dec 30; 31(30):4175-89. Pu M, Hayashi T, Cottam H, Mulvaney J, Arkin M, Corr M, Carson D, Messer K. PMID: 22763983; PMCID: PMC3635947.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    124. Novel cruzain inhibitors for the treatment of Chagas' disease. Chem Biol Drug Des. 2012 Sep; 80(3):398-405. Rogers KE, Keränen H, Durrant JD, Ratnam J, Doak A, Arkin MR, McCammon JA. PMID: 22613098; PMCID: PMC3503458.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    125. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nat Med. 2012 Jun; 18(6):956-60. Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. PMID: 22610278; PMCID: PMC3411919.
      View in: PubMed   Mentions: 150     Fields:    Translation:Animals
    126. Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. ACS Med Chem Lett. 2012 Mar 08; 3(3):203-6. Zhong M, Gadek TR, Bui M, Shen W, Burnier J, Barr KJ, Hanan EJ, Oslob JD, Yu CH, Zhu J, Arkin MR, Evanchik MJ, Flanagan WM, Hoch U, Hyde J, Prabhu S, Silverman JA, Wright J. PMID: 24900456; PMCID: PMC4025648.
      View in: PubMed   Mentions: 27  
    127. Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis. BMC Genomics. 2012; 13 Suppl 1:S4. Lee H, Moody-Davis A, Saha U, Suzuki BM, Asarnow D, Chen S, Arkin M, Caffrey CR, Singh R. PMID: 22369037; PMCID: PMC3471343.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    128. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J Biol Chem. 2011 Sep 30; 286(39):34147-54. Tang Y, Wells JA, Arkin MR. PMID: 21828056; PMCID: PMC3190824.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    129. A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. PLoS Negl Trop Dis. 2011 Jul; 5(7):e1253. De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH. PMID: 21811648; PMCID: PMC3139667.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    130. Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. PMID: 21572521; PMCID: PMC3086806.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    131. Screening technologies for unusual and challenging targets. The FASEB Journal. 2011 Apr 1; 25:314.1-314.1. Arkin AM, Chen CS, Suzuki SB, Popescu PV, Renslo RA, Wells WJ, Singh SR, Caffrey CC. .
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    132. A high-throughput turbidometric assay for screening inhibitors of Leishmania major protein disulfide isomerase. J Biomol Screen. 2011 Jun; 16(5):545-51. Ben Khalaf N, De Muylder G, Ratnam J, Kean-Hooi Ang K, Arkin M, McKerrow J, Chenik M. PMID: 21441416.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    133. An image-based assay for high throughput screening of Giardia lamblia. J Microbiol Methods. 2011 Mar; 84(3):398-405. Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. PMID: 21262276.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    134. Small-molecule inhibitors of IL-2/IL-2R: lessons learned and applied. Curr Top Microbiol Immunol. 2011; 348:25-59. Wilson CG, Arkin MR. PMID: 20703966.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    135. Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2011 Jan 01; 21(1):307-10. Zhong M, Hanan EJ, Shen W, Bui M, Arkin MR, Barr KJ, Evanchik MJ, Hoch U, Hyde J, Martell JR, Oslob JD, Paulvannan K, Prabhu S, Silverman JA, Wright J, Yu CH, Zhu J, Flanagan WM. PMID: 21109434.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    136. Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 01; 20(17):5269-73. Zhong M, Shen W, Barr KJ, Arbitrario JP, Arkin MR, Bui M, Chen T, Cunningham BC, Evanchik MJ, Hanan EJ, Hoch U, Huen K, Hyde J, Kumer JL, Lac T, Lawrence CE, Martell JR, Oslob JD, Paulvannan K, Prabhu S, Silverman JA, Wright J, Yu CH, Zhu J, Flanagan WM. PMID: 20655213.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    137. Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrob Agents Chemother. 2010 Aug; 54(8):3326-34. Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS. PMID: 20547819; PMCID: PMC2916317.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    138. Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. PLoS One. 2010 Apr 15; 5(4):e10186. Hawtin RE, Stockett DE, Byl JA, McDowell RS, Nguyen T, Arkin MR, Conroy A, Yang W, Osheroff N, Fox JA. PMID: 20419121; PMCID: PMC2855444.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    139. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem. 2010 Jan 14; 53(1):52-60. Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ. PMID: 19908842; PMCID: PMC2804034.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    140. Finding Small Molecule Ligands for Protein-Protein Interactions and Other “Undruggable” Targets. Biophysical Journal. 2010 Jan 1; 98(3):411a. Arkin AM. .
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    141. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6218-21. Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. PMID: 19773167; PMCID: PMC3760505.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    142. Two approaches to discovering and developing new drugs for Chagas disease. Mem Inst Oswaldo Cruz. 2009 Jul; 104 Suppl 1:263-9. McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. PMID: 19753483; PMCID: PMC4156466.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimals
    143. The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions. Curr Opin Chem Biol. 2009 Jun; 13(3):284-90. Arkin MR, Whitty A. PMID: 19553156.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    144. The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness. J Nat Prod. 2009 Feb 27; 72(2):218-22. Rubio BK, Tenney K, Ang KH, Abdulla M, Arkin M, McKerrow JH, Crews P. PMID: 19159277; PMCID: PMC2880650.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    145. SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother Pharmacol. 2009 Sep; 64(4):723-32. Conroy A, Stockett DE, Walker D, Arkin MR, Hoch U, Fox JA, Hawtin RE. PMID: 19169685.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCellsCTClinical Trials
    146. HER-2-directed, small-molecule antagonists. Curr Opin Investig Drugs. 2008 Dec; 9(12):1264-76. Arkin M, Moasser MM. PMID: 19037833; PMCID: PMC3031872.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    147. A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties. Bioorg Med Chem Lett. 2008 Nov 01; 18(21):5763-5. Choong IC, Serafimova I, Fan J, Stockett D, Chan E, Cheeti S, Lu Y, Fahr B, Pham P, Arkin MR, Walker DH, Hoch U. PMID: 18842409.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    148. Identification of Nonpeptidic Small-Molecule Inhibitors of Interleukin-2. ChemInform. 2005 Jul 5; 36(27). Waal WN, Yang YW, Oslob OJ, Arkin AM, Hyde HJ, Lu LW, McDowell MR, Yu YC, Raimundo RB. .
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    149. Protein-protein interactions and cancer: small molecules going in for the kill. Curr Opin Chem Biol. 2005 Jun; 9(3):317-24. Arkin M. PMID: 15939335.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    150. Identification of nonpeptidic small-molecule inhibitors of interleukin-2. Bioorg Med Chem Lett. 2005 Feb 15; 15(4):983-7. Waal ND, Yang W, Oslob JD, Arkin MR, Hyde J, Lu W, McDowell RS, Yu CH, Raimundo BC. PMID: 15686897.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    151. Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem. 2004 Jun 03; 47(12):3111-30. Raimundo BC, Oslob JD, Braisted AC, Hyde J, McDowell RS, Randal M, Waal ND, Wilkinson J, Yu CH, Arkin MR. PMID: 15163192.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    152. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov. 2004 Apr; 3(4):301-17. Arkin MR, Wells JA. PMID: 15060526.
      View in: PubMed   Mentions: 518     Fields:    Translation:HumansAnimalsCells
    153. Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2. Biochemistry. 2003 Jun 03; 42(21):6475-83. Hyde J, Braisted AC, Randal M, Arkin MR. PMID: 12767230.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    154. Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J Am Chem Soc. 2003 Apr 02; 125(13):3714-5. Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC. PMID: 12656598.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    155. Binding of small molecules to an adaptive protein-protein interface. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1603-8. Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. PMID: 12582206; PMCID: PMC149879.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    156. Drug discovery at signaling interfaces. Ernst Schering Res Found Workshop. 2003; (42):19-27. Wells J, Arkin M, Braisted A, DeLano W, McDowell B, Oslob J, Raimundo B, Randal M. PMID: 12664533.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    157. A New Data Analysis Method to Determine Binding Constants of Small Molecules to Proteins Using Equilibrium Analytical Ultracentrifugation with Absorption Optics Volume 299, Number 1 (2001), pages 98–107. Analytical Biochemistry. 2002 May 1; 304(2):275. Arkin AM, Lear LJ. .
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    158. A new data analysis method to determine binding constants of small molecules to proteins using equilibrium analytical ultracentrifugation with absorption optics. Anal Biochem. 2001 Dec 01; 299(1):98-107. Arkin M, Lear JD. PMID: 11726190.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    159. Mutational Analysis. Encyclopedia of Genetics. 2001 Jan 1; (Biochemistry351996):1279-1284. Arkin AM. .
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    160. In vitro Mutagenesis. Encyclopedia of Genetics. 2001 Jan 1; (Proceedings of the National Academy of Sciences, USA901993):1010-1014. Arkin AM. .
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    161. In Vitro Mutagenesis. Brenner\u0027s Encyclopedia of Genetics. 2001 Jan 1; (Proceedings of the National Academy of Sciences of the United States of America901993):46-50. Arkin AM. .
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    162. Probing the importance of second sphere residues in an esterolytic antibody by phage display. J Mol Biol. 1998 Dec 11; 284(4):1083-94. Arkin MR, Wells JA. PMID: 9837728.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    163. First Observation of the Key Intermediate in the “Light-Switch” Mechanism of [Ru(phen) 2 dppz] 2+. Journal of the American Chemical Society. 1997 Nov 1; 119(47):11458-11467. Olson OE, Hu HD, Hörmann HA, Jonkman JA, Arkin AM, Stemp SE, Barton BJ, Barbara BP. .
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    164. Long-range oxidation of guanine by Ru(III) in duplex DNA. Chem Biol. 1997 May; 4(5):389-400. Arkin MR, Stemp ED, Pulver SC, Barton JK. PMID: 9195873.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    165. Oxidation of Guanine in DNA by Ru(phen) 2 (dppz) 3+ Using the Flash-Quench Technique. Journal of the American Chemical Society. 1997 Mar 1; 119(12):2921-2925. Stemp SE, Arkin AM, Barton BJ. .
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    166. Rates of DNA-mediated electron transfer between metallointercalators. Science. 1996 Jul 26; 273(5274):475-80. Arkin MR, Stemp ED, Holmlin RE, Barton JK, Hörmann A, Olson EJ, Barbara PF. PMID: 8662532.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    167. Metallointercalators as Probes of the DNA p-way. . 1996 May 5; 246:449-469. Arkin AM, Jenkins JY, Murphy MC, Turro TN, Barton BJ. .
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    168. Time Resolved Electron Transfer Studies Between Metallointercalators in DNA. . 1996 Jan 1; 62:359-360. Hörmann HA, Olson OE, Barbara BP, Arkin AM, Stemp SE, Holmlin HR, Barton BJ. .
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    169. Luminescence Quenching in Supramolecular Systems:  A Comparison of DNA- and SDS Micelle-Mediated Photoinduced Electron Transfer between Metal Complexes. Journal of the American Chemical Society. 1996 Jan 1; 118(9):2267-2274. Arkin AM, Stemp SE, Turro TC, Turro TN, Barton BJ. .
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    170. DNA-mediated electron transfer. Journal of Inorganic Biochemistry. 1995 Aug 1; 59(2-3):132. Barton BJ, Arkin AM, Stemp SE, Holmlin HR, Jenkins JY. .
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    171. Rates of electron transfer reactions between metallointercalators. Journal of Inorganic Biochemistry. 1995 Aug 1; 59(2-3):266. Arkin AM, Stemp SE, Holmin HR, Hoermann HA, Olson OE, Barbara BP, Barton BJ. .
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    172. Tetrahydropterin Reactions of Dioxo-Molybdenum(6+) Complexes: Does Redox Occur?. Journal of the American Chemical Society. 1995 May 1; 117(21):5812-5823. Burgmayer BS, Arkin AM, Bostick BL, Dempster DS, Everett EK, Layton LH, Paul PK, Rogge RC, Rheingold RA. .
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    173. Electron transfer between metallointercalators bound to DNA: Spectral identification of the transient intermediate. Journal of the American Chemical Society. 1995 Mar 1; 117(8):2375-2376. Stemp SE, Arkin AM, Barton BJ. .
      View in: Publisher Site   Mentions:
    174. Fast photoinduced electron transfer through DNA intercalation. Proc Natl Acad Sci U S A. 1994 Jun 07; 91(12):5315-9. Murphy CJ, Arkin MR, Ghatlia ND, Bossmann S, Turro NJ, Barton JK. PMID: 8202486; PMCID: PMC43985.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    175. Long-range photoinduced electron transfer through a DNA helix. Science. 1993 Nov 12; 262(5136):1025-9. Murphy CJ, Arkin MR, Jenkins Y, Ghatlia ND, Bossmann SH, Turro NJ, Barton JK. PMID: 7802858.
      View in: PubMed   Mentions: 80     Fields:    Translation:Cells
    176. Evidence for photoelectron transfer through DNA intercalation. Journal of Inorganic Biochemistry. 1993 Jul 1; 51(1-2):526. Arkin AM, Murphy MC, Jenkins JY, Turro TN, Barton BJ. .
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    177. Redox reactions of reduced pterins with copper and molybdenum complexes. Journal of Inorganic Biochemistry. 1991 Aug 1; 43(2-3):581. Burgmayer BS, Everett EK, Arkin AM, Mosny MK. .
      View in: Publisher Site   Mentions:
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