Stalinraja Maruthamuthu, PhD

Title(s)Postdoctoral Scholar, Surgery
SchoolSchool of Medicine
Address1100 Van Ness Ave., #820
San Francisco CA
ORCID ORCID Icon0000-0003-4298-2121 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Madurai Kamaraj University, IndiaPhD2016Immunology
    Bhat biotech Ltd, Bangalore, IndiaTrainee2008Recombinant arbovirus protein characterization
    Manonmaniam Sundaranar University, Tamil Nadu, IndiaMaster's2007Biotechnology
    Collapse Awards and Honors
    The American Society for Histocompatibility and Immunogenetics2022ASHI Scholar Award
    MDPI journal Special Issue "The Molecular Mechanism of Vascular Remodeling"2022Guest Editor
    Madurai Kamaraj University2012  - 2016Meritorious Fellow
    Madurai Kamaraj University2010  - 2012Genomics Fellow
    Manonmaniam Sundaranar University2006  - 2006TN- Govt. Students (M.Sc., Project) Fellowship

    Collapse Overview 
    Collapse Overview
    I am a postdoctoral Scholar working with Dr.Rajalingam Raja, who is the director of Immunogenetics and Transplantation Laboratory (ITL) at UCSF. My contributions have been recognized with the ASHI (The American Society for Histocompatibility and Immunogenetics) scholar award for the year 2022.

    Additionally, I have taken on the role of guest editor for the journal "Cells" Special Issue titled "The Molecular Mechanism of Vascular Remodeling." During my PhD, my research focused on studying the diversity of NK cell receptors within the Southern Indian population. My findings highlighted the protective role of the NK cell receptor KIR in HIV disease progression.

    Currently, my work at UCSF delves into unraveling the functions of NK cell receptors KIR and FcR in kidney transplantation and their implications in SARS-CoV-2. Our research initiatives involve NK cell-based immune assays, aimed at identifying potential biomarkers for kidney transplant rejection. Moreover, I am actively involved in a desensitization study targeting plasma cells to decrease HLA antibodies, facilitating kidney transplantation for highly sensitized waitlist candidates. Within this clinical trial, I utilize multicolor flow cytometry to analyze B cell subpopulations, seeking to comprehend the therapeutic impact of plasma cell depletion.

    Main theme of my research is to study the influence of host immunogenetic factors against infectious diseases and transplanted organs through molecular and cellular biological approaches.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses. Cell Rep. 2023 07 25; 42(7):112682. Duan M, Nguyen DC, Joyner CJ, Saney CL, Tipton CM, Andrews J, Lonial S, Kim C, Hentenaar I, Kosters A, Ghosn E, Jackson A, Knechtle S, Maruthamuthu S, Chandran S, Martin T, Rajalingam R, Vincenti F, Breeden C, Sanz I, Gibson G, Lee FE. PMID: 37355988; PMCID: PMC10391632.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    2. The microbiome and rheumatic heart disease: current knowledge and future perspectives. Acta Cardiol. 2023 Jul; 78(5):525-533. Nagarajan G, Govindan R, Poomarimuthu M, Andiappan R, Elango S, Maruthamuthu S, Mariakuttikan J, Kadiam S. PMID: 37171266.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses. bioRxiv. 2023 Jan 20. Duan M, Nguyen DC, Joyner CJ, Saney CL, Tipton CM, Andrews J, Lonial S, Kim C, Hentenaar I, Kosters A, Ghosn E, Jackson A, Knechtle S, Maruthamuthu S, Chandran S, Martin T, Rajalingam R, Vincenti F, Breeden C, Sanz I, Gibson G, Eun-Hyung Lee F. PMID: 36711623; PMCID: PMC9882341.
      View in: PubMed   Mentions:
    4. Next-generation sequencing revealed linked alleles of different HLA loci associated with susceptibility and protection to COVID-19. 2022; (83):84. P. Raghav, S. Maruthamuthu, N. Lee, D. Kong, R. Rajalingam, N. Kaur, A. Butte, K. Reyes, C. Chiu, D. Ng, C. Chiu. View Publication.
    5. Individualized Constellation of Killer Cell Immunoglobulin-Like Receptors and Cognate HLA Class I Ligands that Controls Natural Killer Cell Antiviral Immunity Predisposes COVID-19. Front Genet. 2022; 13:845474. Maruthamuthu S, Rajalingam K, Kaur N, Morvan MG, Soto J, Lee N, Kong D, Hu Z, Reyes K, Ng D, Butte AJ, Chiu C, Rajalingam R. PMID: 35273641; PMCID: PMC8902362.
      View in: PubMed   Mentions: 9  
    6. A DECREASE IN KIR-HLA GENE COMBINATIONS THAT INVOLVE IN NK CELL MATURATION IS ASSOCIATED WITH COVID-19. 2021; (82):21. S. Maruthamuthu, J. Soto, N. Lee, D. Kong, R. Rajalingam, . View Publication.
    7. Concurrent typing of over 4000 samples by long-range PCR amplicon-based NGS and rSSO revealed the need to verify NGS typing for HLA allelic dropouts. Hum Immunol. 2021 Aug; 82(8):581-587. Kong D, Lee N, Dela Cruz ID, Dames C, Maruthamuthu S, Golden T, Rajalingam R. PMID: 33980471.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Inhibitory natural killer cell receptor KIR3DL1 with its ligand Bw4 constraints HIV-1 disease among South Indians. AIDS. 2018 11 28; 32(18):2679-2688. Maruthamuthu S, Rajalingam R, Pandian K, Madasamy S, Manoharan M, Pitchai L, Murugesan A, Mariakuttikan J. PMID: 30289808.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. P124 Centromeric BB KIR genotypes that are lacking KIR2DL3 are associated with HIV seropositive individuals of long term non progressor to AIDS. 2017; 78:1. Stalinraja, Maruthamuthu; Suresh, Madasamy; Mythreyee, Manoharan; Rajalingam, Raja; Jayalakshmi, Mariakuttikan; . View Publication.
    10. Predominance of B haplotype associated KIR genes in Tamil Speaking Dravidians. Hum Immunol. 2015 May; 76(5):344-7. Maruthamuthu S, Mariakuttikan J. PMID: 25842054.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    11. Protective role of Mannose binding Lectin (MBL2) promoter haplotypes on TB infection in South Indian HIV-1 patients. 2014; 14(3):1. Pandian, K., Maruthamuthu, S., Madasamy, S., Mariakuttikan, J . View Publication.
    12. Homozygous KIR2DL3 confers susceptibility to tuberculosis infection in HIV seropositive individuals. 2014; 14(3):1. Maruthamuthu, Stalinraja; Madasamy, Suresh; Mariakuttikan, Jayalakshmi; . View Publication.
    13. Protective effect of KIR3DS1 in asymptomatic HIV-1 seroconverters towards AIDS. 2012; 12(1):1. Stalinraja, M; Kalyanaraman, N; Leishman, P; Suresh, M; Jayalakshmi, M; . View Publication.
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