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Rajalingam Raja, PhD

Title(s)Professor, Surgery
SchoolSchool of Medicine
Phone415-476-0647
ORCID ORCID Icon0000-0001-8821-7877 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Royal College of Pathologists, UKFRCPath2018Histocompatibility and Immunogenetics
    American Board of Histocompatibility and Immunogenetics (ABHI), USAD(ABHI)2008Histocompatibility Testing
    Stanford University, Stanford, CAPost-Doctoral Research2002Immunogenetics
    All India Institute of Medical Sciences, New Delhi, IndiaPh.D.1996Histocompatibility & Immunogenetics
    University of Madras, Chennai, IndiaM.Phil.1989Endocrinology
    Bharathiyar University, Coimbatore, IndiaM.Sc.1988Zoology
    University of Madras, Chennai, IndiaB.Sc.1984Zoology
    Collapse Awards and Honors
    Indian Society for Histocompatibility and Immunogenetics (ISHI)2016Prof. NK Mehra Oration Award 2016
    New York State Department of Health2012Certificate of Qualification, Histocompatibility Laboratory Director
    Department of Public Health, State of California2009Histocompatibility Laboratory Director
    Indian Council of Medical Research (ICMR)1996Shakuntala Amir Chand prize for the best Ph.D. thesis in Biomedical Sciences in India
    FIMSA & IUIS1996Clinical Immunology Training Award
    Bharathiyar University, Coimbatore, India1988University First Rank in post-graduation (M.Sc.: Zoology, Biochemicstry, Molecular Biology)

    Collapse Overview 
    Collapse Overview
    Dr. Raja has over 30 years of experience in studying the basic and clinical aspects of Histocompatibility and Immunogenetics. During the Ph.D. program in the Department of Transplantation Immunology and Immunogenetics, All India Institute of Medical Sciences, Dr. Raja developed DNA-based HLA typing method and studied the diversity of HLA in Asian Indians, and the association between HLA alleles and infectious diseases. During 6 years of postdoctoral training in the Parham laboratory, Stanford University, Dr. Raja defined the KIR genomic diversity in several non-human species. In 2002, Dr. Raja joined as Associate Director of the University of California at Los Angeles (UCLA) Immunogenetics Center, which provides clinical histocompatibility testing. After 11 years of UCLA experience, Dr. Raja became the program director of the University of California San Francisco (UCSF) Immunogenetics and Transplantation Laboratory (ITL), which facilitates over 800 solid organ and bone marrow transplantations per year. As the CLIA-approved Laboratory Director, Clinical Consultant and Technical Supervisor, Dr. Raja provides leadership to all areas of clinical Histocompatibility and Immunogenetics testing including stem cell transplantation, various solid organ transplantations (kidney, pancreas, liver, heart, lung), testing for HLA-associated diseases, and testing for transfusion services. Dr. Raja's current research is focused on understanding the KIR-HLA genomic differences in human populations and their relevance in therapeutic transplantations and disease association. Dr. Raja involves in teaching and training in histocompatibility, immunogenetics and transplant immunology, and mentors post-doctoral research fellows, residents, and visiting scholars.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Diego VP, Luu BW, Hofmann M, Dinh LV, Almeida M, Powell JS, Rajalingam R, Peralta JM, Kumar S, Curran JE, Sauna ZE, Kellerman R, Park Y, Key NS, Escobar MA, Huynh H, Verhagen AM, Williams-Blangero S, Lehmann PV, Maraskovsky E, Blangero J, Howard TE. Quantitative HLA-class-II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A. J Thromb Haemost. 2020 Jan; 18(1):201-216. PMID: 31556206.
      View in: PubMed
    2. Roll GR, Webber AB, Gae DH, Laszik Z, Tavakol M, Mayen L, Cunniffe K, Syed S, Hirose R, Freise C, Feng S, Roberts JP, Ascher NL, Stock PG, Rajalingam R. A virtual crossmatch based strategy facilitates sharing of deceased donor kidneys for highly sensitized recipients. Transplantation. 2019 Aug 19. PMID: 31449187.
      View in: PubMed
    3. Gupta N, Henry RG, Kang SM, Strober J, Lim DA, Ryan T, Perry R, Farrell J, Ulman M, Rajalingam R, Gage A, Huhn SL, Barkovich AJ, Rowitch DH. Long-Term Safety, Immunologic Response, and Imaging Outcomes following Neural Stem Cell Transplantation for Pelizaeus-Merzbacher Disease. Stem Cell Reports. 2019 08 13; 13(2):254-261. PMID: 31378671.
      View in: PubMed
    4. Dehn J, Spellman S, Hurley CK, Shaw BE, Barker JN, Burns LJ, Confer DL, Eapen M, Fernandez-Vina M, Hartzman R, Maiers M, Marino SR, Mueller C, Perales MA, Rajalingam R, Pidala J. Selection of unrelated donors and cord blood units for hematopoietic cell transplantation: guidelines from the NMDP/CIBMTR. Blood. 2019 09 19; 134(12):924-934. PMID: 31292117.
      View in: PubMed
    5. Gao Y, Twigg AR, Hirose R, Roll GR, Nowacki AS, Maytin EV, Vidimos AT, Rajalingam R, Arron ST. Association of HLA Antigen Mismatch With Risk of Developing Skin Cancer After Solid-Organ Transplant. JAMA Dermatol. 2019 03 01; 155(3):307-314. PMID: 30673077.
      View in: PubMed
    6. Rajalingam R. Diversity of Killer Cell Immunoglobulin-Like Receptors and Disease. Clin Lab Med. 2018 12; 38(4):637-653. PMID: 30420058.
      View in: PubMed
    7. Maruthamuthu S, Rajalingam R, Pandian K, Madasamy S, Manoharan M, Pitchai L, Murugesan A, Mariakuttikan J. Inhibitory natural killer cell receptor KIR3DL1 with its ligand Bw4 constraints HIV-1 disease among South Indians. AIDS. 2018 11 28; 32(18):2679-2688. PMID: 30289808.
      View in: PubMed
    8. Calabrese DR, Florez R, Dewey K, Hui C, Torgerson D, Chong T, Faust H, Rajalingam R, Hays SR, Golden JA, Kukreja J, Singer JP, Greenland JR. Genotypes associated with tacrolimus pharmacokinetics impact clinical outcomes in lung transplant recipients. Clin Transplant. 2018 08; 32(8):e13332. PMID: 29920787.
      View in: PubMed
    9. Chheda ZS, Kohanbash G, Okada K, Jahan N, Sidney J, Pecoraro M, Yang X, Carrera DA, Downey KM, Shrivastav S, Liu S, Lin Y, Lagisetti C, Chuntova P, Watchmaker PB, Mueller S, Pollack IF, Rajalingam R, Carcaboso AM, Mann M, Sette A, Garcia KC, Hou Y, Okada H. Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy. J Exp Med. 2018 01 02; 215(1):141-157. PMID: 29203539.
      View in: PubMed
    10. Boudreau JE, Giglio F, Gooley TA, Stevenson PA, Le Luduec JB, Shaffer BC, Rajalingam R, Hou L, Hurley CK, Noreen H, Reed EF, Yu N, Vierra-Green C, Haagenson M, Malkki M, Petersdorf EW, Spellman S, Hsu KC. KIR3DL1/HLA-B Subtypes Govern Acute Myelogenous Leukemia Relapse After Hematopoietic Cell Transplantation. J Clin Oncol. 2017 07 10; 35(20):2268-2278. PMID: 28520526.
      View in: PubMed
    11. Greenland JR, Sun H, Calabrese D, Chong T, Singer JP, Kukreja J, Hays SR, Golden JA, Caughey GH, Venstrom JM, Rajalingam R. HLA Mismatching Favoring Host-Versus-Graft NK Cell Activity Via KIR3DL1 Is Associated With Improved Outcomes Following Lung Transplantation. Am J Transplant. 2017 Aug; 17(8):2192-2199. PMID: 28375571.
      View in: PubMed
    12. Faust HE, Golden JA, Rajalingam R, Wang AS, Green G, Hays SR, Kukreja J, Singer JP, Wolters PJ, Greenland JR. Short lung transplant donor telomere length is associated with decreased CLAD-free survival. Thorax. 2017 11; 72(11):1052-1054. PMID: 28446663.
      View in: PubMed
    13. Rajalingam R. The Impact of HLA Class I-Specific Killer Cell Immunoglobulin-Like Receptors on Antibody-Dependent Natural Killer Cell-Mediated Cytotoxicity and Organ Allograft Rejection. Front Immunol. 2016; 7:585. PMID: 28066408.
      View in: PubMed
    14. Greenland JR, Wong CM, Ahuja R, Wang AS, Uchida C, Golden JA, Hays SR, Leard LE, Rajalingam R, Singer JP, Kukreja J, Wolters PJ, Caughey GH, Tang Q. Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts. Transplantation. 2016 10; 100(10):2090-8. PMID: 27077597.
      View in: PubMed
    15. Norman PJ, Hollenbach JA, Nemat-Gorgani N, Marin WM, Norberg SJ, Ashouri E, Jayaraman J, Wroblewski EE, Trowsdale J, Rajalingam R, Oksenberg JR, Chiaroni J, Guethlein LA, Traherne JA, Ronaghi M, Parham P. Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing. Am J Hum Genet. 2016 Aug 04; 99(2):375-91. PMID: 27486779.
      View in: PubMed
    16. Levinson RD, Yung M, Meguro A, Ashouri E, Yu F, Mizuki N, Ohno S, Rajalingam R. KIR and HLA Genotypes Implicated in Reduced Killer Lymphocytes Immunity Are Associated with Vogt-Koyanagi-Harada Disease. PLoS One. 2016; 11(8):e0160392. PMID: 27490240.
      View in: PubMed
    17. Faridi RM, Kemp TJ, Dharmani-Khan P, Lewis V, Tripathi G, Rajalingam R, Daly A, Berka N, Storek J, Masood Khan F. Donor-Recipient Matching for KIR Genotypes Reduces Chronic GVHD and Missing Inhibitory KIR Ligands Protect against Relapse after Myeloablative, HLA Matched Hematopoietic Cell Transplantation. PLoS One. 2016; 11(6):e0158242. PMID: 27341514.
      View in: PubMed
    18. Sun H, Lin DC, Cao Q, Guo X, Marijon H, Zhao Z, Gery S, Xu L, Yang H, Pang B, Lee VK, Lim HJ, Doan N, Said JW, Chu P, Mayakonda A, Thomas T, Forscher C, Baloglu E, Shacham S, Rajalingam R, Koeffler HP. CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1-Dependent IGF-1 Signaling. Cancer Res. 2016 05 01; 76(9):2687-97. PMID: 26956669.
      View in: PubMed
    19. Heaney AP, Sumerel B, Rajalingam R, Bergsneider M, Yong WH, Liau LM. HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis. J Clin Endocrinol Metab. 2015 Nov; 100(11):4092-7. PMID: 26317559.
      View in: PubMed
    20. Lin L, Ma C, Wei B, Aziz N, Rajalingam R, Yusung S, Erlich HA, Trachtenberg EA, Targan SR, McGovern DP, Heath JR, Braun J. Human NK cells licensed by killer Ig receptor genes have an altered cytokine program that modifies CD4+ T cell function. J Immunol. 2014 Jul 15; 193(2):940-9. PMID: 24935928.
      View in: PubMed
    21. Osman AE, Mubasher M, ElSheikh NE, AlHarthi H, Al Yami AS, Rajalingam R, Al-Dehaimi A, Middleton D, ElGhazali G. Characterization of human killer immunoglobulin-like receptors (KIRs) among healthy Saudis. Hum Immunol. 2014 Jun; 75(6):536-40. PMID: 24613458.
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    22. Rajalingam R, Ashouri E. Gene-specific PCR typing of killer cell immunoglobulin-like receptors. Methods Mol Biol. 2013; 1034:239-55. PMID: 23775740.
      View in: PubMed
    23. Vierra-Green C, Roe D, Hou L, Hurley CK, Rajalingam R, Reed E, Lebedeva T, Yu N, Stewart M, Noreen H, Hollenbach JA, Guethlein LA, Wang T, Spellman S, Maiers M. Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals. PLoS One. 2012; 7(11):e47491. PMID: 23139747.
      View in: PubMed
    24. Sauna ZE, Ameri A, Kim B, Yanover C, Viel KR, Rajalingam R, Cole SA, Howard TE. Observations regarding the immunogenicity of BDD-rFVIII derived from a mechanistic personalized medicine perspective. J Thromb Haemost. 2012 Sep; 10(9):1961-5. PMID: 22734827.
      View in: PubMed
    25. Rajalingam R. Overview of the killer cell immunoglobulin-like receptor system. Methods Mol Biol. 2012; 882:391-414. PMID: 22665247.
      View in: PubMed
    26. Rajalingam R. Human diversity of killer cell immunoglobulin-like receptors and disease. Korean J Hematol. 2011 Dec; 46(4):216-28. PMID: 22259627.
      View in: PubMed
    27. Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, Gragert L, Babrzadeh F, Gharizadeh B, Luo M, Plummer FA, Kimani J, Carrington M, Middleton D, Rajalingam R, Beksac M, Marsh SG, Maiers M, Guethlein LA, Tavoularis S, Little AM, Green RE, Norman PJ, Parham P. The shaping of modern human immune systems by multiregional admixture with archaic humans. Science. 2011 Oct 07; 334(6052):89-94. PMID: 21868630.
      View in: PubMed
    28. Solgi G, Ghafari H, Ashouri E, Alimoghdam K, Rajalingam R, Amirzargar A. Comparison of KIR gene content profiles revealed a difference between northern and southern Persians in the distribution of KIR2DS5 and its linked loci. Hum Immunol. 2011 Nov; 72(11):1079-83. PMID: 21867738.
      View in: PubMed
    29. Rajalingam R, Gebel HM. KIR-HLA mismatching in human renal allograft transplantation: emergence of a new concept. Am J Transplant. 2011 Sep; 11(9):1771-2. PMID: 21714847.
      View in: PubMed
    30. Sanchez-Mazas A, Fernandez-Viña M, Middleton D, Hollenbach JA, Buhler S, Di D, Rajalingam R, Dugoujon JM, Mack SJ, Thorsby E. Immunogenetics as a tool in anthropological studies. Immunology. 2011 Jun; 133(2):143-64. PMID: 21480890.
      View in: PubMed
    31. Mackensen F, David F, Schwenger V, Smith LK, Rajalingam R, Levinson RD, Austin CR, Houghton D, Martin TM, Rosenbaum JT. HLA-DRB1*0102 is associated with TINU syndrome and bilateral, sudden-onset anterior uveitis but not with interstitial nephritis alone. Br J Ophthalmol. 2011 Jul; 95(7):971-5. PMID: 21059595.
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    32. Abi-Rached L, Moesta AK, Rajalingam R, Guethlein LA, Parham P. Human-specific evolution and adaptation led to major qualitative differences in the variable receptors of human and chimpanzee natural killer cells. PLoS Genet. 2010 Nov 04; 6(11):e1001192. PMID: 21079681.
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    33. Levinson RD, Okada AA, Ashouri E, Keino H, Rajalingam R. Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals. Hum Immunol. 2010 Feb; 71(2):192-4. PMID: 19897003.
      View in: PubMed
    34. Bonagura VR, Du Z, Ashouri E, Luo L, Hatam LJ, DeVoti JA, Rosenthal DW, Steinberg BM, Abramson AL, Gjertson DW, Reed EF, Rajalingam R. Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis. Hum Immunol. 2010 Feb; 71(2):212-9. PMID: 19861144.
      View in: PubMed
    35. Levinson RD, Martin TM, Luo L, Ashouri E, Rosenbaum JT, Smith JR, Austin CR, Lutt JR, Rajalingam R. Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1505-10. PMID: 19850842.
      View in: PubMed
    36. Ashouri E, Farjadian S, Reed EF, Ghaderi A, Rajalingam R. KIR gene content diversity in four Iranian populations. Immunogenetics. 2009 Jul; 61(7):483-92. PMID: 19521696.
      View in: PubMed
    37. Ashouri E, Ghaderi A, Reed EF, Rajalingam R. A novel duplex SSP-PCR typing method for KIR gene profiling. Tissue Antigens. 2009 Jul; 74(1):62-7. PMID: 19392793.
      View in: PubMed
    38. Alves LG, Rajalingam R, Canavez F. A novel real-time PCR method for KIR genotyping. Tissue Antigens. 2009 Feb; 73(2):188-91. PMID: 19140829.
      View in: PubMed
    39. Shastry A, Sedimbi SK, Rajalingam R, Nikitina-Zake L, Rumba I, Wigzell H, Sanjeevi CB. Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians. Int J Immunogenet. 2008 Dec; 35(6):439-46. PMID: 19046302.
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    40. Shastry A, Sedimbi SK, Rajalingam R, Rumba I, Kanungo A, Sanjeevi CB. Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations. Ann N Y Acad Sci. 2008 Dec; 1150:133-8. PMID: 19120281.
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    41. Rajalingam R. Variable interactions of recipient killer cell immunoglobulin-like receptors with self and allogenic human leukocyte antigen class I ligands may influence the outcome of solid organ transplants. Curr Opin Organ Transplant. 2008 Aug; 13(4):430-7. PMID: 18685341.
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    42. Du Z, Sharma SK, Spellman S, Reed EF, Rajalingam R. KIR2DL5 alleles mark certain combination of activating KIR genes. Genes Immun. 2008 Jul; 9(5):470-80. PMID: 18509341.
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    43. Levinson RD, Du Z, Luo L, Holland GN, Rao NA, Reed EF, Rajalingam R. KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease. Hum Immunol. 2008 Jun; 69(6):349-53. PMID: 18571006.
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    44. Rajalingam R, Du Z, Meenagh A, Luo L, Kavitha VJ, Pavithra-Arulvani R, Vidhyalakshmi A, Sharma SK, Balazs I, Reed EF, Pitchappan RM, Middleton D. Distinct diversity of KIR genes in three southern Indian populations: comparison with world populations revealed a link between KIR gene content and pre-historic human migrations. Immunogenetics. 2008 May; 60(5):207-17. PMID: 18369612.
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    45. Kulkarni S, Single RM, Martin MP, Rajalingam R, Badwe R, Joshi N, Carrington M. Comparison of the rapidly evolving KIR locus in Parsis and natives of India. Immunogenetics. 2008 Apr; 60(3-4):121-9. PMID: 18351333.
      View in: PubMed
    46. Levinson RD, Du Z, Luo L, Monnet D, Tabary T, Brezin AP, Zhao L, Gjertson DW, Holland GN, Reed EF, Cohen JH, Rajalingam R. Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals. Genes Immun. 2008 Apr; 9(3):249-58. PMID: 18340360.
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    47. Luo L, Du Z, Sharma SK, Cullen R, Spellman S, Reed EF, Rajalingam R. Chain-terminating natural mutations affect the function of activating KIR receptors 3DS1 and 2DS3. Immunogenetics. 2007 Oct; 59(10):779-92. PMID: 17646980.
      View in: PubMed
    48. Rajalingam R. Killer cell immunoglobulin-like receptors influence the innate and adaptive immune responses. Iran J Immunol. 2007 Jun; 4(2):61-78. PMID: 17652846.
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    49. Du Z, Gjertson DW, Reed EF, Rajalingam R. Receptor-ligand analyses define minimal killer cell Ig-like receptor (KIR) in humans. Immunogenetics. 2007 Jan; 59(1):1-15. PMID: 17103212.
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    50. Levinson RD, See RF, Rajalingam R, Reed EF, Park MS, Rao NA, Holland GN. HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California. Hum Immunol. 2004 Dec; 65(12):1477-82. PMID: 15603876.
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    51. Levinson RD, Rajalingam R, Park MS, Reed EF, Gjertson DW, Kappel PJ, See RF, Rao NA, Holland GN. Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy. Am J Ophthalmol. 2004 Oct; 138(4):631-4. PMID: 15488792.
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    52. Jin YP, Fishbein MC, Said JW, Jindra PT, Rajalingam R, Rozengurt E, Reed EF. Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells. Hum Immunol. 2004 Apr; 65(4):291-302. PMID: 15120184.
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    53. Rajalingam R, Ge P, Reed EF. A sequencing-based typing method for HLA-DQA1 alleles. Hum Immunol. 2004 Apr; 65(4):373-9. PMID: 15120193.
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    54. Rajalingam R, Parham P, Abi-Rached L. Domain shuffling has been the main mechanism forming new hominoid killer cell Ig-like receptors. J Immunol. 2004 Jan 01; 172(1):356-69. PMID: 14688344.
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    55. Yawata M, Yawata N, McQueen KL, Cheng NW, Guethlein LA, Rajalingam R, Shilling HG, Parham P. Predominance of group A KIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression. Immunogenetics. 2002 Nov; 54(8):543-50. PMID: 12439616.
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    56. Rajalingam R, Krausa P, Shilling HG, Stein JB, Balamurugan A, McGinnis MD, Cheng NW, Mehra NK, Parham P. Distinctive KIR and HLA diversity in a panel of north Indian Hindus. Immunogenetics. 2002 Mar; 53(12):1009-19. PMID: 11904677.
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    57. Shum BP, Flodin LR, Muir DG, Rajalingam R, Khakoo SI, Cleland S, Guethlein LA, Uhrberg M, Parham P. Conservation and variation in human and common chimpanzee CD94 and NKG2 genes. J Immunol. 2002 Jan 01; 168(1):240-52. PMID: 11751968.
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    58. Canavez F, Young NT, Guethlein LA, Rajalingam R, Khakoo SI, Shum BP, Parham P. Comparison of chimpanzee and human leukocyte Ig-like receptor genes reveals framework and rapidly evolving genes. J Immunol. 2001 Nov 15; 167(10):5786-94. PMID: 11698452.
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    59. Mehra NK, Jaini R, Rajalingam R, Balamurugan A, Kaur G. Molecular diversity of HLA-A*02 in Asian Indians: predominance of A*0211. Tissue Antigens. 2001 Jun; 57(6):502-7. PMID: 11556980.
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    60. Gardiner CM, Guethlein LA, Shilling HG, Pando M, Carr WH, Rajalingam R, Vilches C, Parham P. Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism. J Immunol. 2001 Mar 01; 166(5):2992-3001. PMID: 11207248.
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    61. Rajalingam R, Hong M, Adams EJ, Shum BP, Guethlein LA, Parham P. Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes. J Exp Med. 2001 Jan 01; 193(1):135-46. PMID: 11136827.
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    62. Rajalingam R, Gardiner CM, Canavez F, Vilches C, Parham P. Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors. Tissue Antigens. 2001 Jan; 57(1):22-31. PMID: 11169255.
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    63. Vilches C, Pando MJ, Rajalingam R, Gardiner CM, Parham P. Discovery of two novel variants of KIR2DS5 reveals this gene to be a common component of human KIR 'B' haplotypes. Tissue Antigens. 2000 Nov; 56(5):453-6. PMID: 11144295.
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    64. Rajalingam R, Mehra NK, Jain RC. Cold reactive lymphocytotoxic antibodies in pulmonary tuberculosis: correlation with disease activity and HLA. Indian J Exp Biol. 2000 Jul; 38(7):643-50. PMID: 11215305.
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    65. Rajalingam R, Mehra NK, Singal DP. Polymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians. Indian J Exp Biol. 2000 Jul; 38(7):658-62. PMID: 11215307.
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    66. Khakoo SI, Rajalingam R, Shum BP, Weidenbach K, Flodin L, Muir DG, Canavez F, Cooper SL, Valiante NM, Lanier LL, Parham P. Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans. Immunity. 2000 Jun; 12(6):687-98. PMID: 10894168.
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    67. Vilches C, Rajalingam R, Uhrberg M, Gardiner CM, Young NT, Parham P. KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains. J Immunol. 2000 Jun 01; 164(11):5797-804. PMID: 10820258.
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    68. Shum BP, Rajalingam R, Magor KE, Azumi K, Carr WH, Dixon B, Stet RJ, Adkison MA, Hedrick RP, Parham P. A divergent non-classical class I gene conserved in salmonids. Immunogenetics. 1999 Jun; 49(6):479-90. PMID: 10380691.
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    69. Mehra NK, Mitra DK, Rajalingam R. Polymorphic MHC molecules dictate cytokine profile and clinical disease in mycobacterial diseases. Indian J Clin Biochem. 1997 Dec; 12(Suppl 1):100. PMID: 23100914.
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    70. Rajalingam R, Mehra NK, Mehra RD, Neolia S, Jain RC, Pande JN. HLA class I profile in Asian Indian patients with pulmonary tuberculosis. Indian J Exp Biol. 1997 Oct; 35(10):1055-9. PMID: 9475039.
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    71. Habeeb MA, Rajalingam R, Dhar A, Kumar A, Sharma MP, Mehra NK. HLA association and occurrence of autoantibodies in Asian-Indian patients with ulcerative colitis. Am J Gastroenterol. 1997 May; 92(5):772-6. PMID: 9149183.
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    72. Rajalingam R, Singal DP, Mehra NK. Transporter associated with antigen-processing (TAP) genes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis. Tissue Antigens. 1997 Feb; 49(2):168-72. PMID: 9062973.
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    73. Mitra DK, Rajalingam R, Taneja V, Bhattacharyya BC, Mehra NK. HLA-DR polymorphism modulates the cytokine profile of Mycobacterium leprae HSP-reactive CD4+ T cells. Clin Immunol Immunopathol. 1997 Jan; 82(1):60-7. PMID: 9000043.
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    74. Rajalingam R, Mehra NK, Chopra GS, Puri MM, Jain RC. Anti-IgG autoantibodies and possible immune regulatory mechanisms in patients with pulmonary tuberculosis. Tuber Lung Dis. 1996 Dec; 77(6):502-9. PMID: 9039442.
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    75. Mehra NK, Rajalingam R, Sagar S, Jain S, Sharma BK. Direct role of HLA-B5 in influencing susceptibility to Takayasu aortoarteritis. Int J Cardiol. 1996 Aug; 54 Suppl:S71-9. PMID: 9119529.
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    76. Rajalingam R, Mehra NK, Pande JN, Jain RC, Singla R. Correlation of serum interleukin-2 receptor-alpha levels with clinical manifestations in pulmonary tuberculosis. Tuber Lung Dis. 1996 Aug; 77(4):374-9. PMID: 8796256.
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    77. Rajalingam R, Mehra NK, Jain RC, Myneedu VP, Pande JN. Polymerase chain reaction--based sequence-specific oligonucleotide hybridization analysis of HLA class II antigens in pulmonary tuberculosis: relevance to chemotherapy and disease severity. J Infect Dis. 1996 Mar; 173(3):669-76. PMID: 8627031.
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    78. Mehra NK, Rajalingam R, Giphart MJ. Generation of DR51-associated DQA1, DQB1 haplotypes in Asian Indians. Tissue Antigens. 1996 Jan; 47(1):85-9. PMID: 8929717.
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