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FDA's Final Rule on Laboratory-Developed Tests: What Is the Impact on Clinical Pharmacogenomics in the United States? J Appl Lab Med. 2025 Mar 03; 10(2):510-513.
van Wijk XMR, McMillin GA. PMID: 39365749.
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Advances in Cardiac Troponin Composition Assays: A Step Closer to the Clinic? Clin Chem. 2025 Mar 03; 71(3):342-344.
van Wijk XMR, Damen SAJ. PMID: 39697111.
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An Introduction to the Complete Blood Count for Clinical Chemists: White Blood Cells. J Appl Lab Med. 2025 Mar 03; 10(2):459-475.
Osa-Andrews B, van Wijk XMR, Herrera Rivera N, Seifert RP, Harris NS, Marin MJ. PMID: 39873240.
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An Introduction to the Complete Blood Count for Clinical Chemists: Red Blood Cells. J Appl Lab Med. 2024 Sep 03; 9(5):1025-1039.
Marin MJ, van Wijk XMR, Boothe PD, Harris NS, Winter WE. PMID: 38646908.
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FDA's Final Rule on Laboratory Developed Tests. Clin Chem. 2024 Sep 03; 70(9):1192-1194.
van Wijk XMR, Master SR, Genzen JR. PMID: 39222938.
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Humans
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An Introduction to the Complete Blood Count for Clinical Chemists: Platelets. J Appl Lab Med. 2024 Jul 01; 9(4):833-847.
van Wijk XMR, Sanchez Oviol Z, Winter WE, Harris NS, Marin MJ. PMID: 38549553.
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HumansCells
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Advances in sepsis biomarkers. Adv Clin Chem. 2024; 119:117-166.
Marin MJ, van Wijk XMR, Chambliss AB. PMID: 38514209.
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1 Fields:
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Humans
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The stability of blood gases and CO-oximetry under slushed ice and room temperature conditions. Clin Chem Lab Med. 2023 09 26; 61(10):1750-1759.
Zavorsky GS, van Wijk XMR. PMID: 37015069.
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Humans
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Reducing Specimen Rejection Rates Using Concentration-Dependent Hemolysis Rejection Thresholds. J Appl Lab Med. 2023 Mar 06; 8(2):285-295.
Tang NY, Mitchell KR, Groboske SE, Baldwin AD, Lenza M, Yeo KJ, van Wijk XMR. PMID: 36592084.
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Humans
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Implementation of pharmacogenomics into inpatient general medicine. Pharmacogenet Genomics. 2023 Feb 01; 33(2):19-23.
Chen T, O'Donnell PH, Middlestadt M, Ruhnke GW, Danahey K, van Wijk XMR, Choksi A, Knoebel R, Hartman S, Yeo KJ, Friedman PN, Ratain MJ, Nutescu EA, O'Leary KJ, Perera MA, Meltzer DO. PMID: 36729768.
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4 Fields:
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Humans
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Machine Learning in Healthcare: Mapping a Path to Title 21. Clin Chem. 2022 Mar 31; 68(4):609-610.
Marin MJ, Van Wijk XMR, Durant TJS. PMID: 36149375.
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1 Fields:
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Humans
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Stability of Whole Blood Electrolyte Specimens at Room Temperature vs. Slushed Ice Conditions. J Appl Lab Med. 2022 03 02; 7(2):541-554.
Zavorsky GS, van Wijk XMR, Gasparyan S, Stollenwerk NS, Brooks RA. PMID: 34448844.
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1 Fields:
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Humans
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Pilot Findings of Pharmacogenomics in Perioperative Care: Initial Results From the First Phase of the ImPreSS Trial. Anesth Analg. 2022 Nov 01; 135(5):929-940.
Truong TM, Apfelbaum JL, Danahey K, Schierer E, Ludwig J, George D, House L, Karrison T, Shahul S, Anitescu M, Choksi A, Hartman S, Knoebel RW, van Wijk XMR, Yeo KJ, Meltzer DO, Ratain MJ, O'Donnell PH. PMID: 35213469; PMCID: PMC9402808.
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Humans
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Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing. Cancer. 2022 Apr 15; 128(8):1649-1657.
Reizine NM, Danahey K, Truong TM, George D, House LK, Karrison TG, van Wijk XMR, Yeo KJ, Ratain MJ, O'Donnell PH. PMID: 35090043; PMCID: PMC9153953.
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2 Fields:
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Humans
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Development of an LC-MS/MS Method for Measurement of Irinotecan and Its Major Metabolites in Plasma: Technical Considerations. Lab Med. 2022 Jan 06; 53(1):47-52.
Aoullay Z, Van Wijk XMR, Yanhui M, Meddah B, Lynch KL, Cherrah Y, Wu AHB. PMID: 34351422.
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1 Fields:
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Humans
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Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients. J Pers Med. 2021 Dec 10; 11(12).
Saulsberry L, Danahey K, Middlestadt M, O'Leary KJ, Nutescu EA, Chen T, Lee JC, Ruhnke GW, George D, House L, van Wijk XMR, Yeo KJ, Choksi A, Hartman SW, Knoebel RW, Friedman PN, Rasmussen LV, Ratain MJ, Perera MA, Meltzer DO, O'Donnell PH. PMID: 34945816; PMCID: PMC8709436.
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1
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Large inter-assay difference of serum creatinine in pediatric population: a threat to accurate staging of chronic kidney disease. Pediatr Nephrol. 2022 Mar; 37(3):677-681.
Lao K, Sykes E, van Wijk XMR, Li J, Williams J, Gherasim C, Sun Q. PMID: 34757479.
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3 Fields:
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Humans
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Validation of a Large Custom-Designed Pharmacogenomics Panel on an Array Genotyping Platform. J Appl Lab Med. 2021 Nov 01; 6(6):1505-1516.
Tang NY, Pei X, George D, House L, Danahey K, Lipschultz E, Ratain MJ, O'Donnell PH, Yeo KJ, van Wijk XMR. PMID: 34263311; PMCID: PMC8561785.
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6 Fields:
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Humans
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Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among Opioid-Treated Oncology Patients. Oncologist. 2021 Nov; 26(11):e2042-e2052.
Reizine N, Danahey K, Schierer E, Liu P, Middlestadt M, Ludwig J, Truong TM, van Wijk XMR, Yeo KJ, Malec M, Ratain MJ, O'Donnell PH. PMID: 34423496; PMCID: PMC8571740.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Role of von Willebrand Factor in COVID-19 Associated Coagulopathy. J Appl Lab Med. 2021 09 01; 6(5):1305-1315.
Mei ZW, van Wijk XMR, Pham HP, Marin MJ. PMID: 33930144; PMCID: PMC8135722.
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21 Fields:
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HumansCells
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A retrospective analysis of high sensitivity cardiac troponin-T ranges in non-myocardial infarction emergency department visits. BMC Cardiovasc Disord. 2021 Jun 07; 21(1):283.
Kong N, Chua RFM, Besser SA, Heelan L, Nathan S, Spiegel TF, van Wijk XMR, Tabit CE. PMID: 34098902; PMCID: PMC8186234.
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3 Fields:
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Humans
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Short-term analytical imprecision for a fifth generation cardiac troponin T assay does not exceed rule-in and rule-out thresholds of the ESC 0/1-h algorithm. Clin Chim Acta. 2021 Aug; 519:204-205.
Tang NY, Datoru AD, van Wijk XMR. PMID: 33989613.
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Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality. J Appl Lab Med. 2021 04 29; 6(3):592-605.
van Wijk XMR, Yun C, Lynch KL. PMID: 33382901.
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6 Fields:
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Humans
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Cardiac Troponin Composition Characterization after Non ST-Elevation Myocardial Infarction: Relation with Culprit Artery, Ischemic Time Window, and Severity of Injury. Clin Chem. 2021 01 08; 67(1):227-236.
Damen SAJ, Cramer GE, Dieker HJ, Gehlmann H, Ophuis TJMO, Aengevaeren WRM, Fokkert M, Verheugt FWA, Suryapranata H, Wu AH, van Wijk XMR, Brouwer MA. PMID: 33418572.
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3 Fields:
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Humans
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Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial. Ther Adv Med Oncol. 2020; 12:1758835920974118.
Reizine N, Vokes EE, Liu P, Truong TM, Nanda R, Fleming GF, Catenacci DVT, Pearson AT, Parsad S, Danahey K, van Wijk XMR, Yeo KJ, Ratain MJ, O'Donnell PH. PMID: 33414846; PMCID: PMC7750903.
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4
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Analytical and Clinical Evaluation of the Automated Elecsys Anti-SARS-CoV-2 Antibody Assay on the Roche cobas e602 Analyzer. Am J Clin Pathol. 2020 Oct 13; 154(5):620-626.
Chan CW, Parker K, Tesic V, Baldwin A, Tang NY, van Wijk XMR, Yeo KJ. PMID: 32814955; PMCID: PMC7454296.
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19 Fields:
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HumansCells
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A comparison of venous blood gas analysis with paired specimens collected in syringes and evacuated blood collection tubes. Clin Chim Acta. 2020 Nov; 510:671-674.
Tang NY, Leanse JH, Tesic V, van Wijk XMR. PMID: 32818493.
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Evaluation of interference effects from hemolysis, icterus and lipemia on the Roche Elecsys® Anti-SARS-CoV-2 assay. Clin Chim Acta. 2020 Oct; 509:293-294.
Tang NY, Yeo KJ, van Wijk XMR. PMID: 32598879; PMCID: PMC7318977.
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1 Fields:
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HumansCellsPHPublic Health
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Pharmacogenomic-Based Decision Support to Predict Adherence to Medications. Clin Pharmacol Ther. 2020 Aug; 108(2):368-376.
Christian C, Borden BA, Danahey K, Yeo KJ, van Wijk XMR, Ratain MJ, O'Donnell PH. PMID: 32236960; PMCID: PMC7363565.
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PubMed Mentions:
6 Fields:
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Humans
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Can We Improve Current Cancer Screening Programs? Clin Chem. 2020 05 01; 66(5):746.
Marin MJ, van Wijk XMR. PMID: 32353138.
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HumansPHPublic Health
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False-Positive Hepatitis B Surface Antibody Results: An Example of Reagent Carryover. J Appl Lab Med. 2020 Mar 01; 5(2):429-431.
Tang NY, Groboske SE, Baldwin AD, Yeo KJ, van Wijk XMR. PMID: 32445392.
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1 Fields:
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Humans
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A root cause analysis of 'falsely elevated' oxygen saturation: investigation of pneumatic tube transport and differences between estimated and measured saturation in a critical patient population. Clin Chem Lab Med. 2020 Feb 25; 58(3):e72-e74.
van Wijk XMR, Leanse JH, Poinier A, Uriel N, O'Connor MF, Weber SG, Tesic V, Staneva I. PMID: 31525163.
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The ImPreSS Trial: Implementation of Point-of-Care Pharmacogenomic Decision Support in Perioperative Care. Clin Pharmacol Ther. 2019 Dec; 106(6):1179-1183.
Truong TM, Apfelbaum J, Shahul S, Anitescu M, Danahey K, Knoebel RW, Liebovitz D, Karrison T, van Wijk XMR, Yeo KJ, Meltzer D, Ratain MJ, O'Donnell PH. PMID: 31433489; PMCID: PMC7214100.
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8 Fields:
Translation:
HumansCTClinical Trials
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Evaluation of a New Generation Automated Assay for 25-Hydroxy Vitamin D Based on Competitive Protein Binding. J Appl Lab Med. 2019 Sep; 4(2):247-253.
Asif M, Groboske SE, Leung EKY, Yeo KJ, van Wijk XMR. PMID: 31639671.
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2 Fields:
Translation:
HumansCells
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Cardiac troponin I is present in plasma of type 1 myocardial infarction patients and patients with troponin I elevations due to other etiologies as complex with little free I. Clin Biochem. 2019 Nov; 73:35-43.
van Wijk XMR, Claassen S, Enea NS, Li P, Yang S, Brouwer MA, Cramer GE, Zuk R, Lynch KL, Wu AHB. PMID: 31247187.
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3 Fields:
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HumansAnimalsCells
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A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines. J Anal Toxicol. 2019 May 01; 43(4):316-320.
van Wijk XMR, Yun C, Hooshfar S, Arens AM, Lung D, Wu AHB, Lynch KL. PMID: 30462225.
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5 Fields:
Translation:
HumansPHPublic Health
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Mass spectrometry in emergency toxicology: Current state and future applications. Crit Rev Clin Lab Sci. 2019 06; 56(4):225-238.
Van Wijk XMR, Goodnough R, Colby JM. PMID: 30931660.
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6 Fields:
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HumansAnimalsPHPublic Health
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Losing sight of the Forest for the trees: Why clinical laboratories need to perform their own interference studies. Clin Chim Acta. 2018 08; 483:239-240.
Marin MJ, van Wijk XMR, Yeo KJ. PMID: 29750966.
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Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Sci Rep. 2017 08 21; 7(1):9008.
Ihse E, Yamakado H, van Wijk XM, Lawrence R, Esko JD, Masliah E. PMID: 28827536; PMCID: PMC5566500.
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66 Fields:
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HumansAnimalsCells
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Anticholinergic toxicity associated with ingestion of water containing lupini bean extract. Clin Toxicol (Phila). 2017 08; 55(7):687-688.
Li K, van Wijk XMR, Hayashi S, Lynch KL, Wu AHB, Smollin CG. PMID: 28443353.
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1 Fields:
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HumansAnimals
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PubMed Mentions:
1 Fields:
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HumansCellsPHPublic Health
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Whole-Genome Sequencing of Invasion-Resistant Cells Identifies Laminin α2 as a Host Factor for Bacterial Invasion. mBio. 2017 01 10; 8(1).
van Wijk XM, Döhrmann S, Hallström BM, Li S, Voldborg BG, Meng BX, McKee KK, van Kuppevelt TH, Yurchenco PD, Palsson BO, Lewis NE, Nizet V, Esko JD. PMID: 28074024; PMCID: PMC5225314.
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15 Fields:
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AnimalsCells
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Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse. Clin Toxicol (Phila). 2017 Jan; 55(1):71-72.
Vo KT, van Wijk XM, Wu AH, Lynch KL, Ho RY. PMID: 27736261.
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7 Fields:
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HumansPHPublic Health
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A comparison of methods for evaluation of a case of suspected macro-aspartate aminotransferase. Clin Chim Acta. 2016 Dec 01; 463:1-3.
van Wijk XMR, Magee CA, Wu AHB, Tana MM, Lynch KL. PMID: 27732874.
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3 Fields:
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HumansCells
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Adverse Effects From Counterfeit Alprazolam Tablets. JAMA Intern Med. 2016 10 01; 176(10):1554-1555.
Arens AM, van Wijk XM, Vo KT, Lynch KL, Wu AH, Smollin CG. PMID: 27532131.
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22 Fields:
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HumansPHPublic Health
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Counterfeit Norco Poisoning Outbreak - San Francisco Bay Area, California, March 25-April 5, 2016. MMWR Morb Mortal Wkly Rep. 2016 Apr 29; 65(16):420-3.
Vo KT, van Wijk XM, Lynch KL, Wu AH, Smollin CG. PMID: 27123589.
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6 Fields:
Translation:
HumansPHPublic Health
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Heparan Sulfate Modulates Neutrophil and Endothelial Function in Antibacterial Innate Immunity. Infect Immun. 2015 Sep; 83(9):3648-56.
Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC. PMID: 26150541; PMCID: PMC4534644.
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22 Fields:
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AnimalsCells
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A common sugar-nucleotide-mediated mechanism of inhibition of (glycosamino)glycan biosynthesis, as evidenced by 6F-GalNAc (Ac3). FASEB J. 2015 Jul; 29(7):2993-3002.
van Wijk XM, Lawrence R, Thijssen VL, van den Broek SA, Troost R, van Scherpenzeel M, Naidu N, Oosterhof A, Griffioen AW, Lefeber DJ, van Delft FL, van Kuppevelt TH. PMID: 25868729; PMCID: PMC4478805.
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16 Fields:
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HumansAnimalsCells
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Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction? Clin Chim Acta. 2015 Jun 15; 446:6-8.
Aw TC, van Wijk XM, Wu AH, Jaffe AS. PMID: 25862921.
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3 Fields:
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Humans
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A new ultra-high sensitivity troponin I assay for chest pain patients with no evidence of troponin I using a conventional assay. Clin Biochem. 2015 Mar; 48(4-5):358-9.
Wu AH, van Wijk XM. PMID: 25482854.
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1 Fields:
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Humans
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'Immunosequencing' of heparan sulfate from human cell lines and rat kidney: the (GlcNS6S-IdoA2S)₃ motif, recognized by antibody NS4F5, is located towards the non-reducing end. Biochem J. 2014 Aug 01; 461(3):461-8.
van Wijk XM, Oosterhof A, Versteeg EM, van de Westerlo EM, van Kuppevelt TH. PMID: 24819558.
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1 Fields:
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HumansAnimalsCells
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Modulation of heparan sulfate in the glomerular endothelial glycocalyx decreases leukocyte influx during experimental glomerulonephritis. Kidney Int. 2014 Nov; 86(5):932-42.
Rops AL, Loeven MA, van Gemst JJ, Eversen I, Van Wijk XM, Dijkman HB, van Kuppevelt TH, Berden JH, Rabelink TJ, Esko JD, van der Vlag J. PMID: 24759151.
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24 Fields:
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AnimalsCells
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Heparan sulfate in angiogenesis: a target for therapy. Angiogenesis. 2014 Jul; 17(3):443-62.
van Wijk XM, van Kuppevelt TH. PMID: 24146040.
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32 Fields:
Translation:
HumansAnimals
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Interfering with UDP-GlcNAc metabolism and heparan sulfate expression using a sugar analogue reduces angiogenesis. ACS Chem Biol. 2013 Oct 18; 8(10):2331-8.
van Wijk XM, Thijssen VL, Lawrence R, van den Broek SA, Dona M, Naidu N, Oosterhof A, van de Westerlo EM, Kusters LJ, Khaled Y, Jokela TA, Nowak-Sliwinska P, Kremer H, Stringer SE, Griffioen AW, van Wijk E, van Delft FL, van Kuppevelt TH. PMID: 23972127; PMCID: PMC3821560.
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11 Fields:
Translation:
AnimalsCells
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The distribution and function of chondroitin sulfate and other sulfated glycosaminoglycans in the human bladder and their contribution to the protective bladder barrier. J Urol. 2013 Jan; 189(1):336-42.
Janssen DA, van Wijk XM, Jansen KC, van Kuppevelt TH, Heesakkers JP, Schalken JA. PMID: 23174248.
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23 Fields:
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Humans
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The polybasic insertion in autotaxin α confers specific binding to heparin and cell surface heparan sulfate proteoglycans. J Biol Chem. 2013 Jan 04; 288(1):510-9.
Houben AJ, van Wijk XM, van Meeteren LA, van Zeijl L, van de Westerlo EM, Hausmann J, Fish A, Perrakis A, van Kuppevelt TH, Moolenaar WH. PMID: 23150666; PMCID: PMC3537048.
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22 Fields:
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HumansCells
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Extraction and structural analysis of glycosaminoglycans from formalin-fixed, paraffin-embedded tissues. Glycobiology. 2012 Dec; 22(12):1666-72.
van Wijk XM, Vallen MJ, van de Westerlo EM, Oosterhof A, Hao W, Versteeg EM, Raben J, Wismans RG, Smetsers TF, Dijkman HB, Schalkwijk J, van Kuppevelt TH. PMID: 22859440.
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3 Fields:
Translation:
Animals
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Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague-Dawley rats. Epilepsy Res. 2010 Sep; 91(1):28-34.
Rijkers K, Mescheriakova J, Majoie M, Lemmens E, van Wijk X, Philippens M, Van Kranen-Mastenbroek V, Schijns O, Vles J, Hoogland G. PMID: 20638246.
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5 Fields:
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Animals
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A 4-deoxy analogue of N-acetyl-D-glucosamine inhibits heparan sulphate expression and growth factor binding in vitro. Exp Cell Res. 2010 Sep 10; 316(15):2504-12.
van Wijk XM, Oosterhof A, van den Broek SA, Griffioen AW, ten Dam GB, Rutjes FP, van Delft FL, van Kuppevelt TH. PMID: 20433828.
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8 Fields:
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HumansCells