Loading...

Carolyn Hendrickson, MD, MPH

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-476-0735
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoCertificate2014Clinical Research
    University of California, BerkeleyMPH2008Epidemiology
    University of California, San FranciscoM.D.2007 Medicine
    University of California, Santa BarbaraMA 2003Molecular, Cellular, Developmental Biology
    University of California, Santa BarbaraBS2001Molecular, Cellular, Developmental Biology
    University of California, Santa BarbaraBA2001English Literature

    Collapse Overview 
    Collapse Overview
    Dr. Hendrickson is a pulmonary and critical care medicine subspecialist with an expertise and research focus in acute lung injury and acute respiratory distress syndrome (ARDS), the most common life-threatening manifestation of COVID-19 disease. She is the co-medical director of the Medical Intensive Care Unit at Zuckerberg San Francisco General Hospital, the safety-net hospital for our county that has cared for approximately half of all ICU patients with COVID-19 disease in San Francisco. Dr. Hendrickson serves as the physician lead to establish and run the newly established COVID ICU.

    COVID-19 Related Research Efforts:
    As an ARDS translational researchers and the Co-Medical Director of the Intensive Care Unit at Zuckerberg San Francisco General Hospital (ZSFG), Dr. Hendrickson pivoted her research endeavors to study COVID-19 disease with a specific interest in pneumonia and ARDS. She is the site principal investigator for two important COVID-19- related studies:
    1. STAT Trial - a randomized clinical trial sponsored by the Department of Defense testing mesenchymal stromal cells for ARDS that primarily enrolls critically ill patients with ARDS
    from COVID-19
    2. COMET Study- a longitudinal cohort study of hospitalized patients with COVID-19 disease with biospecimen collection sponsored by the National Institute of Health (https://www.comet-study.org). She is also the Clinical Operations Lead and a member of the Executive Committee for the
    COMET study.

    Additionally, Dr. Hendrickson is a co-investigator on two other COVID-19-related randomized controlled clinical trials: one testing COVID-19 convalescent plasma for patients with COVID-19 pneumonia, the CAPRI study, and a second comparing two anticoagulation strategies for hospitalized patients with SARS-CoV-2 infection, ACTIV-4.

    Collapse Research 
    Collapse Research Activities and Funding
    Acute Respiratory Distress Syndrome after Isolated Traumatic Brain Injury: Platelet Biology, Endothelial Activation, and Mechanical Ventilation
    NIH K23HL133495Aug 1, 2016 - Jul 31, 2021
    Role: Principal Investigator
    The Risk of Acute Respiratory Distress Syndrome after Severe Isolated Traumatic B
    NIH F32HL124911Aug 4, 2014 - Aug 3, 2016
    Role: Principal Investigator
    Understanding Asthma Endotypes
    NIH U19AI077439Apr 1, 2008 - Jul 31, 2011
    Role: Executive Committee Member, Co-Investigator, Clinical Operations Lead
    Role Description: UCSF COVID-19 Extended Immunophenotyping Studies: COMET is an NIAID-funded multi-institutional study to collect detailed clinical, laboratory, and radiographic data in coordination with biologic sampling of blood and respiratory secretions and viral shedding in nasal secretions in order to identify immunophenotypic features of COVID-19 -related susceptibility and/or progression in order to generate hypotheses for effective host-directed therapeutic interventions. The COMET study is closely aligned with the multi-center IMPACC study funded by the NIH’s National Institute of Allergy and Infectious Diseases (NIAID), and eligible participants from COMET will be included in IMPACC.

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19. bioRxiv. 2021 Mar 10. van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Voyer TL, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, UCSF COMET consortium , Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ. PMID: 33758859.
      View in: PubMed   Mentions:
    2. Internal and External Validation of an Alcohol Biomarker for Screening in Trauma. Ann Surg. 2021 Feb 01. Afshar M, Baker K, Corral J, Ross E, Lowery E, Gonzalez R, Burnham EL, Callcut RA, Kornblith LZ, Hendrickson C, Kovacs EJ, Joyce C. PMID: 33534233.
      View in: PubMed   Mentions:    Fields:    
    3. Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 Jan 25. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33494096.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. Res Sq. 2021 Jan 14. Sarma A, Christenson S, Mick E, Deiss T, DeVoe C, Pisco A, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha B, Neff N, Tan M, Serpa PH, Ansel KM, Wilson J, Leligdowicz A, Seigel E, Sirota M, DeRisi J, Matthay M, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Calfee C, Langelier C. PMID: 33469573.
      View in: PubMed   Mentions:
    5. 448. Disproportionate Burden of COVID-19 on Latinx Residents among Hospitalized Patients at San Francisco’s Public Health Hospital. Open Forum Infectious Diseases. 2020 Dec 31; 7(Suppl 1):s292-s292. Vivek Jain, Lillian B Brown, Carina Marquez, Luis Rubio, Natasha Spottiswoode, Bethlehem Churnet, Katherine Brooks, Mengyu Zhou, Timothy Muldoon, Carolyn Hendrickson, Adithya Cattamanchi, Antonio Gomez, Brian Haas, Edwin Charlebois, Annie Luetkemeyer, Annie Luetkemeyer, Monica Gandhi, Diane Havlir, Sumant Ranji, Lisa Gail Winston. .
      View in: Publisher Site   Mentions:
    6. Global Absence and Targeting of Protective Immune States in Severe COVID-19. bioRxiv. 2020 Oct 29. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33140050.
      View in: PubMed   Mentions:
    7. Global Absence and Targeting of Protective Immune States in Severe COVID-19. Res Sq. 2020 Oct 28. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33140041.
      View in: PubMed   Mentions:
    8. Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury. Am J Physiol Renal Physiol. 2020 12 01; 319(6):F979-F987. Kwong YD, Mehta KM, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson C, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD. PMID: 33044866.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Higher plasma cystatin C is associated with mortality after acute respiratory distress syndrome: findings from a Fluid and Catheter Treatment Trial (FACTT) substudy. Crit Care. 2020 07 11; 24(1):416. Hendrickson CM, Kwong YD, Belzer AG, Shlipak MG, Matthay MA, Liu KD. PMID: 32653023.
      View in: PubMed   Mentions:    Fields:    
    10. Cigarette Smoking and ARDS After Blunt Trauma: The Influence of Changing Smoking Patterns and Resuscitation Practices. Chest. 2020 Oct; 158(4):1490-1498. Moazed F, Hendrickson C, Conroy A, Kornblith LZ, Benowitz NL, Delucchi K, Cohen MJ, Calfee CS. PMID: 32574574.
      View in: PubMed   Mentions:    Fields:    
    11. Management and Outcomes of Critically-Ill Patients with COVID-19 Pneumonia at a Safety-net Hospital in San Francisco, a Region with Early Public Health Interventions: A Case Series. medRxiv. 2020 May 29. Vanderburg S, Alipanah N, Crowder R, Yoon C, Wang R, Thakur N, Slown K, Shete PB, Rofael M, Metcalfe JZ, Merrifield C, Marquez C, Malcolm K, Lipnick M, Jain V, Gomez A, Burns G, Brown LB, Berger C, Auyeung V, Cattamanchi A, Hendrickson CM. PMID: 32511538.
      View in: PubMed   Mentions:
    12. Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive Care Med. 2020 06; 46(6):1222-1231. Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS. PMID: 32206845.
      View in: PubMed   Mentions: 4     Fields:    
    13. Potential Value of Biomarker Signatures in Sepsis and Acute Respiratory Distress Syndrome in Children and Adults. Crit Care Med. 2020 03; 48(3):428-430. Hendrickson CM, Matthay MA. PMID: 32058380.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Peripheral blood leukocyte telomere length is associated with survival of sepsis patients. Eur Respir J. 2020 01; 55(1). Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ. PMID: 31619475.
      View in: PubMed   Mentions: 5     Fields:    
    15. It's About Time: Transfusion effects on postinjury platelet aggregation over time. J Trauma Acute Care Surg. 2019 11; 87(5):1042-1051. Kornblith LZ, Decker A, Conroy AS, Hendrickson CM, Fields AT, Robles AJ, Callcut RA, Cohen MJ. PMID: 31389915.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    16. Do Plasma Biomarkers Have Value in Identifying Hypoxemic Trauma Patients Who Will Develop ARDS?. Journal of the American College of Surgeons. 2019 Oct 1; 229(4):e225. James T. Ross, Carolyn M. Hendrickson, Brenda Nunez-Garcia, Erin Ross, Amanda Conroy, Michael A. Matthay, Rachael A. Callcut, Lucy Z. Kornblith. .
      View in: Publisher Site   Mentions:
    17. Treatment outcomes among HIV-positive orphaned and non-orphaned children on antiretroviral therapy in Johannesburg, South Africa. S Afr Med J. 2019 Aug 28; 109(9):679-685. Hendrickson C, Evans D, Brennan AT, Patz S, Untiedt S, Bassett J, Levin L, Sanne I, Fox MP. PMID: 31635594.
      View in: PubMed   Mentions:
    18. Embolic Hypodermic Needle Causing Traumatic Cardiac Tamponade: A Case Report. Crit Care Explor. 2019 Aug; 1(8):e0038. Yen AF, Homer CM, Mohapatra A, Langnas E, Gomez A, Hendrickson CM. PMID: 32166279.
      View in: PubMed   Mentions:
    19. A new frontier in ARDS trials: phenotyping before randomisation. Lancet Respir Med. 2019 10; 7(10):830-831. Hendrickson CM, Calfee CS. PMID: 31399380.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Predictors of postinjury acute respiratory distress syndrome: Lung injury persists in the era of hemostatic resuscitation. J Trauma Acute Care Surg. 2019 08; 87(2):371-378. Kornblith LZ, Robles AJ, Conroy AS, Redick BJ, Howard BM, Hendrickson CM, Moore S, Nelson MF, Moazed F, Callcut RA, Calfee CS, Cohen MJ. PMID: 31033882.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Perhaps it's not the platelet: Ristocetin uncovers the potential role of von Willebrand factor in impaired platelet aggregation following traumatic brain injury. J Trauma Acute Care Surg. 2018 11; 85(5):873-880. Kornblith LZ, Robles AJ, Conroy AS, Hendrickson CM, Calfee CS, Fields AT, Callcut RA, Cohen MJ. PMID: 29985231.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care. J Trauma Acute Care Surg. 2018 07; 85(1):148-154. Robles AJ, Kornblith LZ, Hendrickson CM, Howard BM, Conroy AS, Moazed F, Calfee CS, Cohen MJ, Callcut RA. PMID: 29958249.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury. Trauma Surg Acute Care Open. 2018; 3(1):e000171. Hendrickson CM, Gibb SL, Miyazawa BY, Keating SM, Ross E, Conroy AS, Calfee CS, Pati S, Cohen MJ. PMID: 30023434.
      View in: PubMed   Mentions:
    24. Endothelial biomarkers in human sepsis: pathogenesis and prognosis for ARDS. Pulm Circ. 2018 Apr-Jun; 8(2):2045894018769876. Hendrickson CM, Matthay MA. PMID: 29575977.
      View in: PubMed   Mentions:
    25. Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure. J Trauma Acute Care Surg. 2018 02; 84(2):365-371. Moazed F, Hendrickson C, Nelson M, Conroy A, Cohen MJ, Calfee CS. PMID: 29140951.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    26. Characterization of distinct coagulopathic phenotypes in injury: Pathway-specific drivers and implications for individualized treatment. J Trauma Acute Care Surg. 2017 06; 82(6):1055-1062. Christie SA, Kornblith LZ, Howard BM, Conroy AS, Kunitake RC, Nelson MF, Hendrickson CM, Calfee CS, Callcut RA, Cohen MJ. PMID: 28338598.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days. . 2017 05 01; 312(5):L579-L585. Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA, . PMID: 28213470.
      View in: PubMed   Mentions:
    28. The acute respiratory distress syndrome following isolated severe traumatic brain injury. J Trauma Acute Care Surg. 2016 06; 80(6):989-97. Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ. PMID: 26881489.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    29. Misclassification of acute respiratory distress syndrome after traumatic injury: The cost of less rigorous approaches. J Trauma Acute Care Surg. 2015 Sep; 79(3):417-24. Hendrickson CM, Dobbins S, Redick BJ, Greenberg MD, Calfee CS, Cohen MJ. PMID: 26307875.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    30. Differences in degree, differences in kind: characterizing lung injury in trauma. J Trauma Acute Care Surg. 2015 Apr; 78(4):735-41. Howard BM, Kornblith LZ, Hendrickson CM, Redick BJ, Conroy AS, Nelson MF, Callcut RA, Calfee CS, Cohen MJ. PMID: 25742257.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    31. Biology and pathology of fibroproliferation following the acute respiratory distress syndrome. Intensive Care Med. 2015 Jan; 41(1):147-50. Hendrickson CM, Crestani B, Matthay MA. PMID: 25480350.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Lifetime trauma exposure and prospective cardiovascular events and all-cause mortality: findings from the Heart and Soul Study. Psychosom Med. 2013 Nov-Dec; 75(9):849-55. Hendrickson CM, Neylan TC, Na B, Regan M, Zhang Q, Cohen BE. PMID: 24149074.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    33. Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic. Semin Respir Crit Care Med. 2013 Aug; 34(4):475-86. Hendrickson CM, Matthay MA. PMID: 23934716.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    34. Differences in biofilm formation and antimicrobial resistance of Pseudomonas aeruginosa isolated from airways of mechanically ventilated patients and cystic fibrosis patients. Int J Antimicrob Agents. 2011 Apr; 37(4):309-15. Fricks-Lima J, Hendrickson CM, Allgaier M, Zhuo H, Wiener-Kronish JP, Lynch SV, Yang K. PMID: 21382698.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells