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Philip Bickler, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-476-1411
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Intracellular signaling in anesthetic and hypoxic preconditioning of neurons
    NIH/NIGMS R01GM052212Aug 1, 1994 - Feb 28, 2012
    Role: Principal Investigator
    BRAIN ION CHANNEL REGULATION IN ANOXIA AND ANESTHESIA
    NIH/NIGMS R29GM052212Aug 1, 1994 - Jul 31, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Louie A, Feiner JR, Bickler P, Rhodes L, Bernstein M, Lucero J. Four Types of Pulse Oximeters Accurately Detect Hypoxia during Low Perfusion and Motion. Anesthesiology. 2018 Mar; 128(3):520-530. PMID: 29200008.
      View in: PubMed
    2. Lipnick MS, Cahill EA, Feiner JR, Bickler P. Comparison of Transcranial Doppler and Ultrasound-Tagged Near Infrared Spectroscopy for Measuring Relative Changes in Cerebral Blood Flow in Human Subjects. Anesth Analg. 2018 Feb; 126(2):579-587. PMID: 29189269.
      View in: PubMed
    3. Schober A, Feiner JR, Bickler P, Rollins MD. Effects of Changes in Arterial Carbon Dioxide and Oxygen Partial Pressures on Cerebral Oximeter Performance. Anesthesiology. 2018 01; 128(1):97-108. PMID: 29084012.
      View in: PubMed
    4. Yang N, Gabatto P, Bickler P. Reduction in N-methyl-D-aspartate Receptor-mediated Cell Death in Hippocampal Neurons by Glucose Reduction Preconditioning. J Neurosurg Anesthesiol. 2017 Oct; 29(4):448-457. PMID: 28368913.
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    5. Srejic U, Larson P, Bickler P. Little Black Boxes: Noncardiac Implantable Electronic Medical Devices and Their Anesthetic and Surgical Implications. Anesth Analg. 2017 07; 125(1):124-138. PMID: 28489640.
      View in: PubMed
    6. Zhou R, Bickler P. Interaction of Isoflurane, Tumor Necrosis Factor-a and ß-Amyloid on Long-term Potentiation in Rat Hippocampal Slices. Anesth Analg. 2017 02; 124(2):582-587. PMID: 28099324.
      View in: PubMed
    7. Bickler P, Feiner J, Rollins M, Meng L. Tissue Oximetry and Clinical Outcomes. Anesth Analg. 2017 01; 124(1):72-82. PMID: 27308951.
      View in: PubMed
    8. Bickler P, Feiner JR, Lipnick MS, Batchelder P, MacLeod DB, Severinghaus JW, et al. Effects of Acute, Profound Hypoxia on Healthy Humans: Implications for Safety of Tests Evaluating Pulse Oximetry or Tissue Oximetry Performance. Anesth Analg. 2017 01; 124(1):146-153. PMID: 27529318.
      View in: PubMed
    9. Bickler P, Cannesson M, Shelley KH. Trends and Challenges in Clinical Monitoring: Papers From the 2015 IAMPOV Symposium. Anesth Analg. 2017 01; 124(1):2-3. PMID: 27551739.
      View in: PubMed
    10. Lewin M, Samuel S, Merkel J, Bickler P. Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation. Toxins (Basel). 2016 08 25; 8(9). PMID: 27571102.
      View in: PubMed
    11. Lipnick MS, Feiner JR, Au P, Bernstein M, Bickler P. The Accuracy of 6 Inexpensive Pulse Oximeters Not Cleared by the Food and Drug Administration: The Possible Global Public Health Implications. Anesth Analg. 2016 08; 123(2):338-45. PMID: 27089002.
      View in: PubMed
    12. Bickler P. Enough Information to Evaluate Clinical Monitors? Anesth Analg. 2016 07; 123(1):254-5. PMID: 27314698.
      View in: PubMed
    13. Kulcke A, Feiner J, Menn I, Holmer A, Hayoz J, Bickler P. The Accuracy of Pulse Spectroscopy for Detecting Hypoxemia and Coexisting Methemoglobin or Carboxyhemoglobin. Anesth Analg. 2016 06; 122(6):1856-65. PMID: 27111642.
      View in: PubMed
    14. Bickler P, Clark JP, Gabatto P, Brosnan H. Hypoxic preconditioning and cell death from oxygen/glucose deprivation co-opt a subset of the unfolded protein response in hippocampal neurons. Neuroscience. 2015 Dec 03; 310:306-21. PMID: 26404874.
      View in: PubMed
    15. Lewin MR, Samuel SP, Wexler DS, Bickler P, Vaiyapuri S, Mensh BD. Early Treatment with Intranasal Neostigmine Reduces Mortality in a Mouse Model of Naja naja (Indian Cobra) Envenomation. J Trop Med. 2014; 2014:131835. PMID: 24955095; PMCID: PMC4052076.
      View in: PubMed, PubMed Central
    16. Gregersen M, Lee DH, Gabatto P, Bickler P. Limitations of Mild, Moderate, and Profound Hypothermia in Protecting Developing Hippocampal Neurons After Simulated Ischemia. Ther Hypothermia Temp Manag. 2013 Dec 01; 3(4):178-188. PMID: 24380031.
      View in: PubMed
    17. Bickler P, Feiner JR, Rollins MD. Factors affecting the performance of 5 cerebral oximeters during hypoxia in healthy volunteers. Anesth Analg. 2013 Oct; 117(4):813-23. PMID: 24023027.
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    18. Dubowitz G, Breyer K, Lipnick M, Sall JW, Feiner J, Ikeda K, MacLeod DB, Bickler P. Accuracy of the Lifebox pulse oximeter during hypoxia in healthy volunteers. Anaesthesia. 2013 Dec; 68(12):1220-3. PMID: 23992483.
      View in: PubMed
    19. Brosnan H, Bickler P. Xenon neurotoxicity in rat hippocampal slice cultures is similar to isoflurane and sevoflurane. Anesthesiology. 2013 Aug; 119(2):335-44. PMID: 23591069.
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    20. Lewin MR, Bickler P, Heier T, Feiner J, Montauk L, Mensh B. Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation. Clin Case Rep. 2013 Oct; 1(1):7-15. PMID: 25356201; PMCID: PMC4184533.
      View in: PubMed, PubMed Central
    21. Feiner JR, Rollins MD, Sall JW, Eilers H, Au P, Bickler P. Accuracy of carboxyhemoglobin detection by pulse CO-oximetry during hypoxemia. Anesth Analg. 2013 Oct; 117(4):847-58. PMID: 23477959; PMCID: PMC4476500.
      View in: PubMed, PubMed Central
    22. Sall JW, Stratmann G, Leong J, Woodward E, Bickler P. Propofol at clinically relevant concentrations increases neuronal differentiation but is not toxic to hippocampal neural precursor cells in vitro. Anesthesiology. 2012 Nov; 117(5):1080-90. PMID: 23001052; PMCID: PMC3483886.
      View in: PubMed, PubMed Central
    23. Bickler P, Warren DE, Clark JP, Gabatto P, Gregersen M, Brosnan H. Anesthetic protection of neurons injured by hypothermia and rewarming: roles of intracellular Ca2+ and excitotoxicity. Anesthesiology. 2012 Aug; 117(2):280-92. PMID: 22728782; PMCID: PMC3428020.
      View in: PubMed, PubMed Central
    24. Shih J, May LD, Gonzalez HE, Lee EW, Alvi RS, Sall JW, Rau V, Bickler P, Lalchandani GR, Yusupova M, Woodward E, Kang H, Wilk AJ, Carlston CM, Mendoza MV, Guggenheim JN, Schaefer M, Rowe AM, Stratmann G. Delayed environmental enrichment reverses sevoflurane-induced memory impairment in rats. Anesthesiology. 2012 Mar; 116(3):586-602. PMID: 22354242; PMCID: PMC4146425.
      View in: PubMed, PubMed Central
    25. Pianezza A, Salces y Nedeo A, Chaynes P, Bickler P, Minville V. The emergence level of the musculocutaneous nerve from the brachial plexus: implications for infraclavicular nerve blocks. Anesth Analg. 2012 May; 114(5):1131-3. PMID: 22312122.
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    26. Warren DE, Bickler P, Clark JP, Gregersen M, Brosnan H, McKleroy W, Gabatto P. Hypothermia and rewarming injury in hippocampal neurons involve intracellular Ca2+ and glutamate excitotoxicity. Neuroscience. 2012 Apr 05; 207:316-25. PMID: 22265728.
      View in: PubMed
    27. Bickler P, Fahlman CS, Gray JJ. Hypoxic preconditioning failure in aging hippocampal neurons: impaired gene expression and rescue with intracellular calcium chelation. J Neurosci Res. 2010 Dec; 88(16):3520-9. PMID: 20936695.
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    28. Feiner JR, Bickler P. Improved accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia. Anesth Analg. 2010 Nov; 111(5):1160-7. PMID: 20841412.
      View in: PubMed
    29. Bickler P, Fahlman CS. Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors. Brain Res. 2010 Jun 22; 1340:86-95. PMID: 20434434; PMCID: PMC3478070.
      View in: PubMed, PubMed Central
    30. Rubinsky L, Raichman N, Lavee J, Frenk H, Ben-Jacob E, Bickler P. Antifreeze protein suppresses spontaneous neural activity and protects neurons from hypothermia/re-warming injury. Neurosci Res. 2010 Jul; 67(3):256-9. PMID: 20398707.
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    31. Stratmann G, Sall JW, Bell JS, Alvi RS, May Ld, Ku B, Dowlatshahi M, Dai R, Bickler P, Russell I, Lee MT, Hrubos MW, Chiu C. Isoflurane does not affect brain cell death, hippocampal neurogenesis, or long-term neurocognitive outcome in aged rats. Anesthesiology. 2010 Feb; 112(2):305-15. PMID: 20098132.
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    32. Osredkar D, Sall JW, Bickler P, Ferriero DM. Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke. Neurobiol Dis. 2010 May; 38(2):259-65. PMID: 20117210; PMCID: PMC2854222.
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    33. Feiner JR, Bickler P, Mannheimer PD. Accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia. Anesth Analg. 2010 Jul; 111(1):143-8. PMID: 20007731.
      View in: PubMed
    34. Bickler P, Fahlman CS. Expression of signal transduction genes differs after hypoxic or isoflurane preconditioning of rat hippocampal slice cultures. Anesthesiology. 2009 Aug; 111(2):258-66. PMID: 19568165; PMCID: PMC3478094.
      View in: PubMed, PubMed Central
    35. Baranov D, Bickler P, Crosby GJ, Culley DJ, Eckenhoff MF, Eckenhoff RG, Hogan KJ, Jevtovic-Todorovic V, Palotás A, Perouansky M, Planel E, Silverstein JH, Wei H, Whittington RA, Xie Z, Zuo Z. Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease. Anesth Analg. 2009 May; 108(5):1627-30. PMID: 19372347; PMCID: PMC2769511.
      View in: PubMed, PubMed Central
    36. Bickler P, Fahlman CS, Gray J, McKleroy W. Inositol 1,4,5-triphosphate receptors and NAD(P)H mediate Ca2+ signaling required for hypoxic preconditioning of hippocampal neurons. Neuroscience. 2009 Apr 21; 160(1):51-60. PMID: 19217932; PMCID: PMC2684521.
      View in: PubMed, PubMed Central
    37. Christian SL, Ross AP, Zhao HW, Kristenson HJ, Zhan X, Rasley BT, Bickler P, Drew KL. Arctic ground squirrel (Spermophilus parryii) hippocampal neurons tolerate prolonged oxygen-glucose deprivation and maintain baseline ERK1/2 and JNK activation despite drastic ATP loss. J Cereb Blood Flow Metab. 2008 Jul; 28(7):1307-19. PMID: 18398417; PMCID: PMC2792705.
      View in: PubMed, PubMed Central
    38. Feiner JR, Severinghaus JW, Bickler P. Dark skin decreases the accuracy of pulse oximeters at low oxygen saturation: the effects of oximeter probe type and gender. Anesth Analg. 2007 Dec; 105(6 Suppl):S18-23, tables of contents. PMID: 18048893.
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    39. Bickler P, Buck LT. Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability. Annu Rev Physiol. 2007; 69:145-70. PMID: 17037980.
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    40. Bickler P, Brandes J, Lee M, Bozic K, Chesbro B, Claassen J. Bleeding complications from femoral and sciatic nerve catheters in patients receiving low molecular weight heparin. Anesth Analg. 2006 Oct; 103(4):1036-7. PMID: 17000826.
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    41. Bickler P, Fahlman CS. The inhaled anesthetic, isoflurane, enhances Ca2+-dependent survival signaling in cortical neurons and modulates MAP kinases, apoptosis proteins and transcription factors during hypoxia. Anesth Analg. 2006 Aug; 103(2):419-29, table of contents. PMID: 16861427.
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    42. Zhan X, Fahlman CS, Bickler P. Isoflurane neuroprotection in rat hippocampal slices decreases with aging: changes in intracellular Ca2+ regulation and N-methyl-D-aspartate receptor-mediated Ca2+ influx. Anesthesiology. 2006 May; 104(5):995-1003. PMID: 16645452.
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    43. Platts-Mills TF, Lewin MR, Wells J, Bickler P. Improvised cricothyrotomy provides reliable airway access in an unembalmed human cadaver model. Wilderness Environ Med. 2006; 17(2):81-6. PMID: 16805143.
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    44. Bickler P, Zhan X, Fahlman CS. Isoflurane preconditions hippocampal neurons against oxygen-glucose deprivation: role of intracellular Ca2+ and mitogen-activated protein kinase signaling. Anesthesiology. 2005 Sep; 103(3):532-9. PMID: 16129978.
      View in: PubMed
    45. Bickler P, Feiner JR, Severinghaus JW. Effects of skin pigmentation on pulse oximeter accuracy at low saturation. Anesthesiology. 2005 Apr; 102(4):715-9. PMID: 15791098.
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    46. Gray JJ, Bickler P, Fahlman CS, Zhan X, Schuyler JA. Isoflurane neuroprotection in hypoxic hippocampal slice cultures involves increases in intracellular Ca2+ and mitogen-activated protein kinases. Anesthesiology. 2005 Mar; 102(3):606-15. PMID: 15731600.
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    47. Hedrick MS, Fahlman CS, Bickler P. Intracellular calcium and survival of tadpole forebrain cells in anoxia. J Exp Biol. 2005 Feb; 208(Pt 4):681-6. PMID: 15695760.
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    48. Liu C, Cotten JF, Schuyler JA, Fahlman CS, Au JD, Bickler P, Yost CS. Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress. Brain Res. 2005 Jan 21; 1031(2):164-73. PMID: 15649441.
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    49. Feiner JR, Bickler P, Estrada S, Donohoe PH, Fahlman CS, Schuyler JA. Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures. Anesth Analg. 2005 Jan; 100(1):215-25. PMID: 15616081.
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    50. Bickler P. Clinical perspectives: neuroprotection lessons from hypoxia-tolerant organisms. J Exp Biol. 2004 Aug; 207(Pt 18):3243-9. PMID: 15299045.
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    51. Paige M, Bickler P. Falsely low pulse oximetry values in patients receiving docetaxel (Taxotere). Anesth Analg. 2004 Aug; 99(2):622-3. PMID: 15271755.
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    52. Bickler P, Fahlman CS, Ferriero DM. Hypoxia increases calcium flux through cortical neuron glutamate receptors via protein kinase C. J Neurochem. 2004 Feb; 88(4):878-84. PMID: 14756808.
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    53. Bickler P, Fahlman CS. Moderate increases in intracellular calcium activate neuroprotective signals in hippocampal neurons. Neuroscience. 2004; 127(3):673-83. PMID: 15283966.
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    54. Bickler P, Warner DS, Stratmann G, Schuyler JA. gamma-Aminobutyric acid-A receptors contribute to isoflurane neuroprotection in organotypic hippocampal cultures. Anesth Analg. 2003 Aug; 97(2):564-71, table of contents. PMID: 12873954.
      View in: PubMed
    55. Bickler P, Fahlman CS, Taylor DM. Oxygen sensitivity of NMDA receptors: relationship to NR2 subunit composition and hypoxia tolerance of neonatal neurons. Neuroscience. 2003; 118(1):25-35. PMID: 12676134.
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    56. Fahlman CS, Bickler P, Sullivan B, Gregory GA. Activation of the neuroprotective ERK signaling pathway by fructose-1,6-bisphosphate during hypoxia involves intracellular Ca2+ and phospholipase C. Brain Res. 2002 Dec 20; 958(1):43-51. PMID: 12468029.
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    57. Bickler P, Donohoe PH. Adaptive responses of vertebrate neurons to hypoxia. J Exp Biol. 2002 Dec; 205(Pt 23):3579-86. PMID: 12409484.
      View in: PubMed
    58. Bickler P, Donohoe PH, Buck LT. Molecular adaptations for survival during anoxia: lessons from lower vertebrates. Neuroscientist. 2002 Jun; 8(3):234-42. PMID: 12061503.
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    59. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler P, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. J Cereb Blood Flow Metab. 2002 Mar; 22(3):342-52. PMID: 11891440.
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    60. Sullivan BL, Leu D, Taylor DM, Fahlman CS, Bickler P. Isoflurane prevents delayed cell death in an organotypic slice culture model of cerebral ischemia. Anesthesiology. 2002 Jan; 96(1):189-95. PMID: 11753020.
      View in: PubMed
    61. Donohoe PH, Fahlman CS, Bickler P, Vexler ZS, Gregory GA. Neuroprotection and intracellular Ca2+ modulation with fructose-1,6-bisphosphate during in vitro hypoxia-ischemia involves phospholipase C-dependent signaling. Brain Res. 2001 Nov 02; 917(2):158-66. PMID: 11640901.
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    62. Eilers H, Philip LA, Bickler P, McKay WR, Schumacher MA. The reversal of fentanyl-induced tolerance by administration of "small-dose" ketamine. Anesth Analg. 2001 Jul; 93(1):213-4. PMID: 11429368.
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    63. Liniger R, Popovic R, Sullivan B, Gregory G, Bickler P. Effects of neuroprotective cocktails on hippocampal neuron death in an in vitro model of cerebral ischemia. J Neurosurg Anesthesiol. 2001 Jan; 13(1):19-25. PMID: 11145473.
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    64. Bickler P, Donohoe PH, Buck LT. Hypoxia-induced silencing of NMDA receptors in turtle neurons. J Neurosci. 2000 May 15; 20(10):3522-8. PMID: 10804192.
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    65. Popovic R, Liniger R, Bickler P. Anesthetics and mild hypothermia similarly prevent hippocampal neuron death in an in vitro model of cerebral ischemia. Anesthesiology. 2000 May; 92(5):1343-9. PMID: 10781280.
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    66. Taylor DM, Eger EI, Bickler P. Halothane, but not the nonimmobilizers perfluoropentane and 1,2-dichlorohexafluorocyclobutane, depresses synaptic transmission in hippocampal CA1 neurons in rats. Anesth Analg. 1999 Oct; 89(4):1040-5. PMID: 10512287.
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    67. Eilers H, Kindler CH, Bickler P. Different effects of volatile anesthetics and polyhalogenated alkanes on depolarization-evoked glutamate release in rat cortical brain slices. Anesth Analg. 1999 May; 88(5):1168-74. PMID: 10320189.
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    68. Kindler CH, Eilers H, Donohoe P, Ozer S, Bickler P. Volatile anesthetics increase intracellular calcium in cerebrocortical and hippocampal neurons. Anesthesiology. 1999 Apr; 90(4):1137-45. PMID: 10201687.
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    69. Buck L, Espanol M, Litt L, Bickler P. Reversible decreases in ATP and PCr concentrations in anoxic turtle brain. Comp Biochem Physiol A Mol Integr Physiol. 1998 Aug; 120(4):633-9. PMID: 9828395.
      View in: PubMed
    70. Bickler P. Reduction of NMDA receptor activity in cerebrocortex of turtles (Chrysemys picta) during 6 wk of anoxia. Am J Physiol. 1998 Jul; 275(1 Pt 2):R86-91. PMID: 9688964.
      View in: PubMed
    71. Bickler P, Buck LT. Adaptations of vertebrate neurons to hypoxia and anoxia: maintaining critical Ca2+ concentrations. J Exp Biol. 1998 Apr; 201(Pt 8):1141-52. PMID: 9510526.
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    72. Bickler P, Hansen BM. Hypoxia-tolerant neonatal CA1 neurons: relationship of survival to evoked glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices. Brain Res Dev Brain Res. 1998 Mar 12; 106(1-2):57-69. PMID: 9554954.
      View in: PubMed
    73. Hampson AJ, Bornheim LM, Scanziani M, Yost CS, Gray AT, Hansen BM, Leonoudakis DJ, Bickler P. Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission. J Neurochem. 1998 Feb; 70(2):671-6. PMID: 9453561.
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    74. Buck LT, Bickler P. Adenosine and anoxia reduce N-methyl-D-aspartate receptor open probability in turtle cerebrocortex. J Exp Biol. 1998 Jan; 201(Pt 2):289-97. PMID: 9405320.
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    75. Eilers H, Schaeffer E, Bickler P, Forsayeth JR. Functional deactivation of the major neuronal nicotinic receptor caused by nicotine and a protein kinase C-dependent mechanism. Mol Pharmacol. 1997 Dec; 52(6):1105-12. PMID: 9415721.
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    76. Gray AT, Buck LT, Feiner JR, Bickler P. Interactive effects of pH and temperature on N-methyl-D-aspartate receptor activity in rat cortical brain slices. J Neurosurg Anesthesiol. 1997 Apr; 9(2):180-7. PMID: 9100191.
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    77. Bickler P, Buck LT. Effects of fructose-1,6-bisphosphate on glutamate release and ATP loss from rat brain slices during hypoxia. J Neurochem. 1996 Oct; 67(4):1463-8. PMID: 8858928.
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    78. Talke P, Bickler P. Effects of dexmedetomidine on hypoxia-evoked glutamate release and glutamate receptor activity in hippocampal slices. Anesthesiology. 1996 Sep; 85(3):551-7. PMID: 8853085.
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    79. Eilers H, Bickler P. Hypothermia and isoflurane similarly inhibit glutamate release evoked by chemical anoxia in rat cortical brain slices. Anesthesiology. 1996 Sep; 85(3):600-7. PMID: 8853091.
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    80. Podolsky A, Eldridge MW, Richardson RS, Knight DR, Johnson EC, Hopkins SR, Johnson DH, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler P, Severinghaus JW, Wagner PD. Exercise-induced VA/Q inequality in subjects with prior high-altitude pulmonary edema. J Appl Physiol (1985). 1996 Aug; 81(2):922-32. PMID: 8872664.
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    81. Eldridge MW, Podolsky A, Richardson RS, Johnson DH, Knight DR, Johnson EC, Hopkins SR, Michimata H, Grassi B, Feiner J, Kurdak SS, Bickler P, Wagner PD, Severinghaus JW. Pulmonary hemodynamic response to exercise in subjects with prior high-altitude pulmonary edema. J Appl Physiol (1985). 1996 Aug; 81(2):911-21. PMID: 8872663.
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    82. Bickler P, Hansen BM. Alpha 2-adrenergic agonists reduce glutamate release and glutamate receptor-mediated calcium changes in hippocampal slices during hypoxia. Neuropharmacology. 1996 Jun; 35(6):679-87. PMID: 8887976.
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    83. Bickler P, Buck LT, Feiner JR. Volatile and intravenous anesthetics decrease glutamate release from cortical brain slices during anoxia. Anesthesiology. 1995 Dec; 83(6):1233-40. PMID: 8533916.
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    84. Buck LT, Bickler P. Role of adenosine in NMDA receptor modulation in the cerebral cortex of an anoxia-tolerant turtle (Chrysemys picta belli). J Exp Biol. 1995 Jul; 198(Pt 7):1621-8. PMID: 7658192.
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    85. Feiner JR, Bickler P, Severinghaus JW. Hypoxic ventilatory response predicts the extent of maximal breath-holds in man. Respir Physiol. 1995 Jun; 100(3):213-22. PMID: 7481110.
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    86. Bickler P, Hansen BM. Causes of calcium accumulation in rat cortical brain slices during hypoxia and ischemia: role of ion channels and membrane damage. Brain Res. 1994 Dec 05; 665(2):269-76. PMID: 7534604.
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    87. Bickler P, Buck LT, Hansen BM. Effects of isoflurane and hypothermia on glutamate receptor-mediated calcium influx in brain slices. Anesthesiology. 1994 Dec; 81(6):1461-9. PMID: 7992916.
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    88. Sato M, Severinghaus JW, Bickler P. Time course of augmentation and depression of hypoxic ventilatory responses at altitude. J Appl Physiol (1985). 1994 Jul; 77(1):313-6. PMID: 7961252.
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    89. Cardone C, Szenohradszky J, Yost S, Bickler P. Activation of brain acetylcholine receptors by neuromuscular blocking drugs. A possible mechanism of neurotoxicity. Anesthesiology. 1994 May; 80(5):1155-61; discussion 29A. PMID: 7912481.
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    90. O'Donnell BR, Bickler P. Influence of pH on calcium influx during hypoxia in rat cortical brain slices. Stroke. 1994 Jan; 25(1):171-7. PMID: 8266367.
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    91. Bickler P, Gallego SM, Hansen BM. Developmental changes in intracellular calcium regulation in rat cerebral cortex during hypoxia. J Cereb Blood Flow Metab. 1993 Sep; 13(5):811-9. PMID: 8103057.
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    92. Bickler P, Gallego SM. Inhibition of brain calcium channels by plasma proteins from anoxic turtles. Am J Physiol. 1993 Aug; 265(2 Pt 2):R277-81. PMID: 8103641.
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    93. Szenohradszky J, Trevor AJ, Bickler P, Caldwell JE, Sharma ML, Rampil IJ, Miller RD. Central nervous system effects of intrathecal muscle relaxants in rats. Anesth Analg. 1993 Jun; 76(6):1304-9. PMID: 8098920.
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    94. Bickler P. Cerebral anoxia tolerance in turtles: regulation of intracellular calcium and pH. Am J Physiol. 1992 Dec; 263(6 Pt 2):R1298-302. PMID: 1481942.
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    95. Bickler P, Kelleher JA. Fructose-1,6-bisphosphate stabilizes brain intracellular calcium during hypoxia in rats. Stroke. 1992 Nov; 23(11):1617-22. PMID: 1440710.
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    96. Bickler P, Julian D. Regional cerebral blood flow and tissue oxygenation during hypocarbia in geese. Am J Physiol. 1992 Aug; 263(2 Pt 2):R221-5. PMID: 1510162.
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    97. Bickler P, Sohn YJ. Mass spectrometers and infrared gas analyzers interpret bronchodilator propellants as anesthetic gases. Anesth Analg. 1992 Jul; 75(1):142-3. PMID: 1616143.
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    98. Bickler P. Effects of temperature and anoxia on regional cerebral blood flow in turtles. Am J Physiol. 1992 Mar; 262(3 Pt 2):R538-41. PMID: 1558224.
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    99. Miller AC, Bickler P. The laryngeal mask airway. An unusual complication. Anaesthesia. 1991 Aug; 46(8):659-60. PMID: 1887974.
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    100. Bissonnette B, Bickler P, Gregory GA, Severinghaus JW. Intracranial pressure and brain redox balance in rabbits. Can J Anaesth. 1991 Jul; 38(5):654-9. PMID: 1934221.
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    101. Bickler P, Spears R, McKay W. Intralipid solution mistakenly infused into epidural space. Anesth Analg. 1990 Dec; 71(6):712-3. PMID: 2240651.
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    102. Bickler P, Sessler DI. Efficiency of airway heat and moisture exchangers in anesthetized humans. Anesth Analg. 1990 Oct; 71(4):415-8. PMID: 2400121.
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    103. Bickler P, Schapera A, Bainton CR. Acute radial nerve injury from use of an automatic blood pressure monitor. Anesthesiology. 1990 Jul; 73(1):186-8. PMID: 2360731.
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    104. Bickler P, Gold B, Johnson BH. Diffusion of felt-tip marker pen ink into intravenous bags. Anesth Analg. 1989 Sep; 69(3):412. PMID: 2774247.
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    105. Bickler P, Koh SO, Severinghaus JW. Effects of hypoxia and hypocapnia on brain redox balance in ducks. Am J Physiol. 1989 Jul; 257(1 Pt 2):R132-5. PMID: 2502033.
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    106. Bickler P, Litt L, Banville DL, Severinghaus JW. Effects of acetazolamide on cerebral acid-base balance. J Appl Physiol (1985). 1988 Jul; 65(1):422-7. PMID: 3136134.
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    107. Bickler P, Litt L, Severinghaus JW. Effects of acetazolamide on cerebrocortical NADH and blood volume. J Appl Physiol (1985). 1988 Jul; 65(1):428-33. PMID: 3136135.
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    108. Bickler P, Dueck R, Prutow RJ. Effects of barbiturate anesthesia on functional residual capacity and ribcage/diaphragm contributions to ventilation. Anesthesiology. 1987 Feb; 66(2):147-52. PMID: 3813077.
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    109. Weinstein Y, Bernstein MH, Bickler P, Gonzales DV, Samaniego FC, Escobedo MA. Blood respiratory properties in pigeons at high altitudes: effects of acclimation. Am J Physiol. 1985 Dec; 249(6 Pt 2):R765-75. PMID: 3934990.
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    110. Bickler P. Blood acid-base status of an awake heterothermic rodent, Spermophilus tereticaudus. Respir Physiol. 1984 Sep; 57(3):307-16. PMID: 6441212.
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    111. Bickler P. CO2 balance of a heterothermic rodent: comparison of sleep, torpor, and awake states. Am J Physiol. 1984 Jan; 246(1 Pt 2):R49-55. PMID: 6421175.
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