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Philip Bickler, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentAnesthesia
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-476-1411
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Intracellular signaling in anesthetic and hypoxic preconditioning of neurons
    NIH/NIGMS R01GM052212Aug 1, 1994 - Feb 28, 2012
    Role: Principal Investigator
    BRAIN ION CHANNEL REGULATION IN ANOXIA AND ANESTHESIA
    NIH/NIGMS R29GM052212Aug 1, 1994 - Jul 31, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lundeberg J, Feiner JR, Schober A, Sall JW, Eilers H, Bickler P. Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels. High Alt Med Biol. 2018 Jun 20. PMID: 29924642.
      View in: PubMed
    2. Louie A, Feiner JR, Bickler P, Rhodes L, Bernstein M, Lucero J. Four Types of Pulse Oximeters Accurately Detect Hypoxia during Low Perfusion and Motion. Anesthesiology. 2018 Mar; 128(3):520-530. PMID: 29200008.
      View in: PubMed
    3. Lipnick MS, Cahill EA, Feiner JR, Bickler P. Comparison of Transcranial Doppler and Ultrasound-Tagged Near Infrared Spectroscopy for Measuring Relative Changes in Cerebral Blood Flow in Human Subjects. Anesth Analg. 2018 Feb; 126(2):579-587. PMID: 29189269.
      View in: PubMed
    4. Schober A, Feiner JR, Bickler P, Rollins MD. Effects of Changes in Arterial Carbon Dioxide and Oxygen Partial Pressures on Cerebral Oximeter Performance. Anesthesiology. 2018 01; 128(1):97-108. PMID: 29084012.
      View in: PubMed
    5. Yang N, Gabatto P, Bickler P. Reduction in N-methyl-D-aspartate Receptor-mediated Cell Death in Hippocampal Neurons by Glucose Reduction Preconditioning. J Neurosurg Anesthesiol. 2017 Oct; 29(4):448-457. PMID: 28368913.
      View in: PubMed
    6. Srejic U, Larson P, Bickler P. Little Black Boxes: Noncardiac Implantable Electronic Medical Devices and Their Anesthetic and Surgical Implications. Anesth Analg. 2017 07; 125(1):124-138. PMID: 28489640.
      View in: PubMed
    7. Zhou R, Bickler P. Interaction of Isoflurane, Tumor Necrosis Factor-a and ß-Amyloid on Long-term Potentiation in Rat Hippocampal Slices. Anesth Analg. 2017 02; 124(2):582-587. PMID: 28099324.
      View in: PubMed
    8. Bickler P, Feiner JR, Lipnick MS, Batchelder P, MacLeod DB, Severinghaus JW. Effects of Acute, Profound Hypoxia on Healthy Humans: Implications for Safety of Tests Evaluating Pulse Oximetry or Tissue Oximetry Performance. Anesth Analg. 2017 01; 124(1):146-153. PMID: 27529318.
      View in: PubMed
    9. Bickler P, Feiner J, Rollins M, Meng L. Tissue Oximetry and Clinical Outcomes. Anesth Analg. 2017 01; 124(1):72-82. PMID: 27308951.
      View in: PubMed
    10. Bickler P, Cannesson M, Shelley KH. Trends and Challenges in Clinical Monitoring: Papers From the 2015 IAMPOV Symposium. Anesth Analg. 2017 01; 124(1):2-3. PMID: 27551739.
      View in: PubMed
    11. Lewin M, Samuel S, Merkel J, Bickler P. Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation. Toxins (Basel). 2016 08 25; 8(9). PMID: 27571102.
      View in: PubMed
    12. Lipnick MS, Feiner JR, Au P, Bernstein M, Bickler P. The Accuracy of 6 Inexpensive Pulse Oximeters Not Cleared by the Food and Drug Administration: The Possible Global Public Health Implications. Anesth Analg. 2016 08; 123(2):338-45. PMID: 27089002.
      View in: PubMed
    13. Bickler P. Enough Information to Evaluate Clinical Monitors? Anesth Analg. 2016 07; 123(1):254-5. PMID: 27314698.
      View in: PubMed
    14. Kulcke A, Feiner J, Menn I, Holmer A, Hayoz J, Bickler P. The Accuracy of Pulse Spectroscopy for Detecting Hypoxemia and Coexisting Methemoglobin or Carboxyhemoglobin. Anesth Analg. 2016 06; 122(6):1856-65. PMID: 27111642.
      View in: PubMed
    15. Lewin MR, Samuel SP, Wexler DS, Bickler P, Vaiyapuri S, Mensh BD. Early Treatment with Intranasal Neostigmine Reduces Mortality in a Mouse Model of Naja naja (Indian Cobra) Envenomation. J Trop Med. 2014; 2014:131835. PMID: 24955095; PMCID: PMC4052076.
    16. Gregersen M, Lee DH, Gabatto P, Bickler P. Limitations of Mild, Moderate, and Profound Hypothermia in Protecting Developing Hippocampal Neurons After Simulated Ischemia. Ther Hypothermia Temp Manag. 2013 Dec 01; 3(4):178-188. PMID: 24380031.
      View in: PubMed
    17. Bickler P, Feiner JR, Rollins MD. Factors affecting the performance of 5 cerebral oximeters during hypoxia in healthy volunteers. Anesth Analg. 2013 Oct; 117(4):813-23. PMID: 24023027.
      View in: PubMed
    18. Brosnan H, Bickler P. Xenon neurotoxicity in rat hippocampal slice cultures is similar to isoflurane and sevoflurane. Anesthesiology. 2013 Aug; 119(2):335-44. PMID: 23591069.
      View in: PubMed
    19. Lewin MR, Bickler P, Heier T, Feiner J, Montauk L, Mensh B. Reversal of experimental paralysis in a human by intranasal neostigmine aerosol suggests a novel approach to the early treatment of neurotoxic envenomation. Clin Case Rep. 2013 Oct; 1(1):7-15. PMID: 25356201; PMCID: PMC4184533.
    20. Feiner JR, Rollins MD, Sall JW, Eilers H, Au P, Bickler P. Accuracy of carboxyhemoglobin detection by pulse CO-oximetry during hypoxemia. Anesth Analg. 2013 Oct; 117(4):847-58. PMID: 23477959; PMCID: PMC4476500.
    21. Sall JW, Stratmann G, Leong J, Woodward E, Bickler P. Propofol at clinically relevant concentrations increases neuronal differentiation but is not toxic to hippocampal neural precursor cells in vitro. Anesthesiology. 2012 Nov; 117(5):1080-90. PMID: 23001052; PMCID: PMC3483886.
    22. Bickler P, Warren DE, Clark JP, Gabatto P, Gregersen M, Brosnan H. Anesthetic protection of neurons injured by hypothermia and rewarming: roles of intracellular Ca2+ and excitotoxicity. Anesthesiology. 2012 Aug; 117(2):280-92. PMID: 22728782; PMCID: PMC3428020.
    23. Shih J, May LD, Gonzalez HE, Lee EW, Alvi RS, Sall JW, Rau V, Bickler P, Lalchandani GR, Yusupova M, Woodward E, Kang H, Wilk AJ, Carlston CM, Mendoza MV, Guggenheim JN, Schaefer M, Rowe AM, Stratmann G. Delayed environmental enrichment reverses sevoflurane-induced memory impairment in rats. Anesthesiology. 2012 Mar; 116(3):586-602. PMID: 22354242; PMCID: PMC4146425.
    24. Pianezza A, Salces y Nedeo A, Chaynes P, Bickler P, Minville V. The emergence level of the musculocutaneous nerve from the brachial plexus: implications for infraclavicular nerve blocks. Anesth Analg. 2012 May; 114(5):1131-3. PMID: 22312122.
      View in: PubMed
    25. Bickler P, Fahlman CS, Gray JJ. Hypoxic preconditioning failure in aging hippocampal neurons: impaired gene expression and rescue with intracellular calcium chelation. J Neurosci Res. 2010 Dec; 88(16):3520-9. PMID: 20936695.
      View in: PubMed
    26. Feiner JR, Bickler P. Improved accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia. Anesth Analg. 2010 Nov; 111(5):1160-7. PMID: 20841412.
      View in: PubMed
    27. Bickler P, Fahlman CS. Enhanced hypoxic preconditioning by isoflurane: signaling gene expression and requirement of intracellular Ca2+ and inositol triphosphate receptors. Brain Res. 2010 Jun 22; 1340:86-95. PMID: 20434434; PMCID: PMC3478070.
    28. Rubinsky L, Raichman N, Lavee J, Frenk H, Ben-Jacob E, Bickler P. Antifreeze protein suppresses spontaneous neural activity and protects neurons from hypothermia/re-warming injury. Neurosci Res. 2010 Jul; 67(3):256-9. PMID: 20398707.
      View in: PubMed
    29. Stratmann G, Sall JW, Bell JS, Alvi RS, May Ld, Ku B, Dowlatshahi M, Dai R, Bickler P, Russell I, Lee MT, Hrubos MW, Chiu C. Isoflurane does not affect brain cell death, hippocampal neurogenesis, or long-term neurocognitive outcome in aged rats. Anesthesiology. 2010 Feb; 112(2):305-15. PMID: 20098132.
      View in: PubMed
    30. Osredkar D, Sall JW, Bickler P, Ferriero DM. Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke. Neurobiol Dis. 2010 May; 38(2):259-65. PMID: 20117210; PMCID: PMC2854222.
    31. Feiner JR, Bickler P, Mannheimer PD. Accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia. Anesth Analg. 2010 Jul; 111(1):143-8. PMID: 20007731.
      View in: PubMed
    32. Bickler P, Fahlman CS. Expression of signal transduction genes differs after hypoxic or isoflurane preconditioning of rat hippocampal slice cultures. Anesthesiology. 2009 Aug; 111(2):258-66. PMID: 19568165; PMCID: PMC3478094.
    33. Baranov D, Bickler P, Crosby GJ, Culley DJ, Eckenhoff MF, Eckenhoff RG, Hogan KJ, Jevtovic-Todorovic V, Palotás A, Perouansky M, Planel E, Silverstein JH, Wei H, Whittington RA, Xie Z, Zuo Z. Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease. Anesth Analg. 2009 May; 108(5):1627-30. PMID: 19372347; PMCID: PMC2769511.
    34. Christian SL, Ross AP, Zhao HW, Kristenson HJ, Zhan X, Rasley BT, Bickler P, Drew KL. Arctic ground squirrel (Spermophilus parryii) hippocampal neurons tolerate prolonged oxygen-glucose deprivation and maintain baseline ERK1/2 and JNK activation despite drastic ATP loss. J Cereb Blood Flow Metab. 2008 Jul; 28(7):1307-19. PMID: 18398417; PMCID: PMC2792705.
    35. Feiner JR, Severinghaus JW, Bickler P. Dark skin decreases the accuracy of pulse oximeters at low oxygen saturation: the effects of oximeter probe type and gender. Anesth Analg. 2007 Dec; 105(6 Suppl):S18-23, tables of contents. PMID: 18048893.
      View in: PubMed
    36. Bickler P, Buck LT. Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability. Annu Rev Physiol. 2007; 69:145-70. PMID: 17037980.
      View in: PubMed
    37. Bickler P, Brandes J, Lee M, Bozic K, Chesbro B, Claassen J. Bleeding complications from femoral and sciatic nerve catheters in patients receiving low molecular weight heparin. Anesth Analg. 2006 Oct; 103(4):1036-7. PMID: 17000826.
      View in: PubMed
    38. Bickler P, Fahlman CS. The inhaled anesthetic, isoflurane, enhances Ca2+-dependent survival signaling in cortical neurons and modulates MAP kinases, apoptosis proteins and transcription factors during hypoxia. Anesth Analg. 2006 Aug; 103(2):419-29, table of contents. PMID: 16861427.
      View in: PubMed
    39. Zhan X, Fahlman CS, Bickler P. Isoflurane neuroprotection in rat hippocampal slices decreases with aging: changes in intracellular Ca2+ regulation and N-methyl-D-aspartate receptor-mediated Ca2+ influx. Anesthesiology. 2006 May; 104(5):995-1003. PMID: 16645452.
      View in: PubMed
    40. Platts-Mills TF, Lewin MR, Wells J, Bickler P. Improvised cricothyrotomy provides reliable airway access in an unembalmed human cadaver model. Wilderness Environ Med. 2006; 17(2):81-6. PMID: 16805143.
      View in: PubMed
    41. Bickler P, Zhan X, Fahlman CS. Isoflurane preconditions hippocampal neurons against oxygen-glucose deprivation: role of intracellular Ca2+ and mitogen-activated protein kinase signaling. Anesthesiology. 2005 Sep; 103(3):532-9. PMID: 16129978.
      View in: PubMed
    42. Bickler P, Feiner JR, Severinghaus JW. Effects of skin pigmentation on pulse oximeter accuracy at low saturation. Anesthesiology. 2005 Apr; 102(4):715-9. PMID: 15791098.
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    43. Gray JJ, Bickler P, Fahlman CS, Zhan X, Schuyler JA. Isoflurane neuroprotection in hypoxic hippocampal slice cultures involves increases in intracellular Ca2+ and mitogen-activated protein kinases. Anesthesiology. 2005 Mar; 102(3):606-15. PMID: 15731600.
      View in: PubMed
    44. Hedrick MS, Fahlman CS, Bickler P. Intracellular calcium and survival of tadpole forebrain cells in anoxia. J Exp Biol. 2005 Feb; 208(Pt 4):681-6. PMID: 15695760.
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    45. Liu C, Cotten JF, Schuyler JA, Fahlman CS, Au JD, Bickler P, Yost CS. Protective effects of TASK-3 (KCNK9) and related 2P K channels during cellular stress. Brain Res. 2005 Jan 21; 1031(2):164-73. PMID: 15649441.
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    46. Feiner JR, Bickler P, Estrada S, Donohoe PH, Fahlman CS, Schuyler JA. Mild hypothermia, but not propofol, is neuroprotective in organotypic hippocampal cultures. Anesth Analg. 2005 Jan; 100(1):215-25. PMID: 15616081.
      View in: PubMed
    47. Bickler P. Clinical perspectives: neuroprotection lessons from hypoxia-tolerant organisms. J Exp Biol. 2004 Aug; 207(Pt 18):3243-9. PMID: 15299045.
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    48. Paige M, Bickler P. Falsely low pulse oximetry values in patients receiving docetaxel (Taxotere). Anesth Analg. 2004 Aug; 99(2):622-3. PMID: 15271755.
      View in: PubMed
    49. Bickler P, Warner DS, Stratmann G, Schuyler JA. gamma-Aminobutyric acid-A receptors contribute to isoflurane neuroprotection in organotypic hippocampal cultures. Anesth Analg. 2003 Aug; 97(2):564-71, table of contents. PMID: 12873954.
      View in: PubMed
    50. Bickler P, Donohoe PH. Adaptive responses of vertebrate neurons to hypoxia. J Exp Biol. 2002 Dec; 205(Pt 23):3579-86. PMID: 12409484.
      View in: PubMed
    51. Bickler P, Donohoe PH, Buck LT. Molecular adaptations for survival during anoxia: lessons from lower vertebrates. Neuroscientist. 2002 Jun; 8(3):234-42. PMID: 12061503.
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    52. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler P, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. J Cereb Blood Flow Metab. 2002 Mar; 22(3):342-52. PMID: 11891440.
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    53. Sullivan BL, Leu D, Taylor DM, Fahlman CS, Bickler P. Isoflurane prevents delayed cell death in an organotypic slice culture model of cerebral ischemia. Anesthesiology. 2002 Jan; 96(1):189-95. PMID: 11753020.
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