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Jianlong Lou

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentAnesthesia
Address1001 Potrero Ave, SFGH 1
San Francisco CA 94110
Phone415-206-4137
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fan Y, Garcia-Rodriguez C, Lou J, Wen W, Conrad F, Zhai W, Smith TJ, Smith LA, Marks JD. A three monoclonal antibody combination potently neutralizes multiple botulinum neurotoxin serotype F subtypes. PLoS One. 2017; 12(3):e0174187. PMID: 28323873.
      View in: PubMed
    2. Fan Y, Barash JR, Lou J, Conrad F, Marks JD, Arnon SS. Immunological Characterization and Neutralizing Ability of Monoclonal Antibodies Directed Against Botulinum Neurotoxin Type H. J Infect Dis. 2016 May 15; 213(10):1606-14. PMID: 26936913; PMCID: PMC4837907.
    3. Fan Y, Dong J, Lou J, Wen W, Conrad F, Geren IN, Garcia-Rodriguez C, Smith TJ, Smith LA, Ho M, Pires-Alves M, Wilson BA, Marks JD. Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B. Toxins (Basel). 2015 Aug 26; 7(9):3405-23. PMID: 26343720; PMCID: PMC4591640.
    4. Fan Y, Geren IN, Dong J, Lou J, Wen W, Conrad F, Smith TJ, Smith LA, Ho M, Pires-Alves M, Wilson BA, Marks JD. Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity. PLoS One. 2015; 10(8):e0135306. PMID: 26275214; PMCID: PMC4537209.
    5. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL. TGF-ß-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 01; 195(3):1182-90. PMID: 26109638; PMCID: PMC4506848.
    6. Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL. Transforming Growth Factor-ß and Interleukin-1ß Signaling Pathways Converge on the Chemokine CCL20 Promoter. J Biol Chem. 2015 Jun 05; 290(23):14717-28. PMID: 25918170; PMCID: PMC4505537.
    7. Jenko KL, Zhang Y, Kostenko Y, Fan Y, Garcia-Rodriguez C, Lou J, Marks JD, Varnum SM. Development of an ELISA microarray assay for the sensitive and simultaneous detection of ten biodefense toxins. Analyst. 2014 Oct 21; 139(20):5093-102. PMID: 25112421.
      View in: PubMed
    8. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. Selective targeting of TGF-ß activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79. PMID: 24944194; PMCID: PMC4341974.
    9. Strotmeier J, Mahrhold S, Krez N, Janzen C, Lou J, Marks JD, Binz T, Rummel A. Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A. FEBS Lett. 2014 Apr 02; 588(7):1087-93. PMID: 24583011; PMCID: PMC4067265.
    10. Janardhanan P, Mello CM, Singh BR, Lou J, Marks JD, Cai S. RNA aptasensor for rapid detection of natively folded type A botulinum neurotoxin. Talanta. 2013 Dec 15; 117:273-80. PMID: 24209341; PMCID: PMC3909959.
    11. Mahrhold S, Strotmeier J, Garcia-Rodriguez C, Lou J, Marks JD, Rummel A, Binz T. Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E. Biochem J. 2013 Jul 01; 453(1):37-47. PMID: 23621114.
      View in: PubMed
    12. Zhang Y, Lou J, Jenko KL, Marks JD, Varnum SM. Simultaneous and sensitive detection of six serotypes of botulinum neurotoxin using enzyme-linked immunosorbent assay-based protein antibody microarrays. Anal Biochem. 2012 Nov 15; 430(2):185-92. PMID: 22935296; PMCID: PMC3589981.
    13. Zhou Y, Goenaga AL, Harms BD, Zou H, Lou J, Conrad F, Adams GP, Schoeberl B, Nielsen UB, Marks JD. Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies. Mol Cancer Ther. 2012 Jul; 11(7):1467-76. PMID: 22564724; PMCID: PMC4209485.
    14. Kalb SR, Santana WI, Geren IN, Garcia-Rodriguez C, Lou J, Smith TJ, Marks JD, Smith LA, Pirkle JL, Barr JR. Extraction and inhibition of enzymatic activity of botulinum neurotoxins /B1, /B2, /B3, /B4, and /B5 by a panel of monoclonal anti-BoNT/B antibodies. BMC Biochem. 2011 Nov 15; 12:58. PMID: 22085466; PMCID: PMC3250939.
    15. Wang Y, Keck ZY, Saha A, Xia J, Conrad F, Lou J, Eckart M, Marks JD, Foung SK. Affinity maturation to improve human monoclonal antibody neutralization potency and breadth against hepatitis C virus. J Biol Chem. 2011 Dec 23; 286(51):44218-33. PMID: 22002064; PMCID: PMC3243554.
    16. Stephen Nishimura, Jianlong Lou, Jody Lynn Baron, James D Marks. Antibodies that bind integrin Alpha-V Beta-8. 2011.
    17. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avß8-mediated activation of TGF-ß. J Clin Invest. 2011 Jul; 121(7):2863-75. PMID: 21646718; PMCID: PMC3223836.
    18. Garcia-Rodriguez C, Geren IN, Lou J, Conrad F, Forsyth C, Wen W, Chakraborti S, Zao H, Manzanarez G, Smith TJ, Brown J, Tepp WH, Liu N, Wijesuriya S, Tomic MT, Johnson EA, Smith LA, Marks JD. Response re: 'Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin' by Garcia-Rodriguez et al., PEDS, 2011;24:321-331. Protein Eng Des Sel. 2011 Apr 18. PMID: 21502303.
      View in: PubMed
    19. Rudnick SI, Lou J, Shaller CC, Tang Y, Klein-Szanto AJ, Weiner LM, Marks JD, Adams GP. Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors. Cancer Res. 2011 Mar 15; 71(6):2250-9. PMID: 21406401; PMCID: PMC3077882.
    20. Stephen Nishimura, Jianlong Lou, Jody Lynn Baron, James D Marks. INTEGRIN aVß8 NEUTRALIZING ANTIBODY. 2010.
    21. Garcia-Rodriguez C, Geren IN, Lou J, Conrad F, Forsyth C, Wen W, Chakraborti S, Zao H, Manzanarez G, Smith TJ, Brown J, Tepp WH, Liu N, Wijesuriya S, Tomic MT, Johnson EA, Smith LA, Marks JD. Neutralizing human monoclonal antibodies binding multiple serotypes of botulinum neurotoxin. Protein Eng Des Sel. 2011 Mar; 24(3):321-31. PMID: 21149386; PMCID: PMC3038462.
    22. James D. Marks, Jianbo Dong, Jianlong Lou. Anti-Botulinum Neurotoxin Antibodies. 2010.
    23. Kalb SR, Garcia-Rodriguez C, Lou J, Baudys J, Smith TJ, Marks JD, Smith LA, Pirkle JL, Barr JR. Extraction of BoNT/A, /B, /E, and /F with a single, high affinity monoclonal antibody for detection of botulinum neurotoxin by Endopep-MS. PLoS One. 2010 Aug 17; 5(8):e12237. PMID: 20808925; PMCID: PMC2923190.
    24. James D Marks, Isin Geren, Maria Consuelo Garcia, Jianlong Lou, Ali Razai. THERAPEUTIC MONOCLONAL ANTIBODIES THAT NEUTRALIZE BOTULINUM NEUROTOXINS. 2010.
    25. James D Marks, Isin Geren, Jianlong Lou. THERAPEUTIC MONOCLONAL ANTIBODIES THAT NEUTRALIZE BOTULINUM NEUROTOXINS. 2010.
    26. Lou J, Geren I, Garcia-Rodriguez C, Forsyth CM, Wen W, Knopp K, Brown J, Smith T, Smith LA, Marks JD. Affinity maturation of human botulinum neurotoxin antibodies by light chain shuffling via yeast mating. Protein Eng Des Sel. 2010 Apr; 23(4):311-9. PMID: 20156888; PMCID: PMC2841544.
    27. Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS. Tumor detection by imaging proteolytic activity. Cancer Res. 2010 Feb 15; 70(4):1505-12. PMID: 20145119; PMCID: PMC2823079.
    28. Dong J, Thompson AA, Fan Y, Lou J, Conrad F, Ho M, Pires-Alves M, Wilson BA, Stevens RC, Marks JD. A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region. J Mol Biol. 2010 Apr 09; 397(4):1106-18. PMID: 20138889; PMCID: PMC2903050.
    29. Jianlong Lou and James D Marks. Antibody Engineering. Roland Kontermann and Stefan Dübel (Eds.). Affinity Maturation by Chain Shuffling and Site Directed Mutagenesis. 2010; 377-396.
    30. Cheng LW, Stanker LH, Henderson TD, Lou J, Marks JD. Antibody protection against botulinum neurotoxin intoxication in mice. Infect Immun. 2009 Oct; 77(10):4305-13. PMID: 19651864; PMCID: PMC2747958.
    31. Ozanich RM, Bruckner-Lea CJ, Warner MG, Miller K, Antolick KC, Marks JD, Lou J, Grate JW. Rapid multiplexed flow cytometric assay for botulinum neurotoxin detection using an automated fluidic microbead-trapping flow cell for enhanced sensitivity. Anal Chem. 2009 Jul 15; 81(14):5783-93. PMID: 19530657.
      View in: PubMed
    32. Warner MG, Grate JW, Tyler A, Ozanich RM, Miller KD, Lou J, Marks JD, Bruckner-Lea CJ. Quantum dot immunoassays in renewable surface column and 96-well plate formats for the fluorescence detection of botulinum neurotoxin using high-affinity antibodies. Biosens Bioelectron. 2009 Sep 15; 25(1):179-84. PMID: 19643593; PMCID: PMC2728038.
    33. Kalb SR, Lou J, Garcia-Rodriguez C, Geren IN, Smith TJ, Moura H, Marks JD, Smith LA, Pirkle JL, Barr JR. Extraction and inhibition of enzymatic activity of botulinum neurotoxins/A1, /A2, and /A3 by a panel of monoclonal anti-BoNT/A antibodies. PLoS One. 2009; 4(4):e5355. PMID: 19399171; PMCID: PMC2670495.
    34. Grate JW, Warner MG, Ozanich RM, Miller KD, Colburn HA, Dockendorff B, Antolick KC, Anheier NC, Lind MA, Lou J, Marks JD, Bruckner-Lea CJ. Renewable surface fluorescence sandwich immunoassay biosensor for rapid sensitive botulinum toxin detection in an automated fluidic format. Analyst. 2009 May; 134(5):987-96. PMID: 19381395.
      View in: PubMed
    35. Marks James D; Geren Isin N; Garcia Maria Consuelo; Lou Jianlong; Razai Ali. Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins. 2009.
    36. Leung KM, Feng DX, Lou J, Zhou Y, Fung KP, Waye MM, Tsui SK, Chan PK, Marks JD, Pang SF, Kan YW. Development of human single-chain antibodies against SARS-associated coronavirus. Intervirology. 2008; 51(3):173-81. PMID: 18724064.
      View in: PubMed
    37. Marks James D; Amersdorfer Peter; Geren Isin; Lou Jianlong; Razai Ali; Garcia Maria Consuelos. Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins. 2008.
    38. Marks James, Garcia Consuelo, Isin N. Geren, Lou J, Charles M. Forsyth, Fraser Conrad, Wen Weihua, Theresa J. Smith, Brown Jennifer, Al-Saleem Fetweh, Ancharski Denise, Lance L. Simpson, William H. Tepp, Eric A. Johnson and Leonard A. Smith. Toxicon. Recombinant antibody potently neutralizes types A, B, and E botulinum neurotoxins by a clearance-driven mechanism. 2008; 51(Summlement):50.
    39. Fischer A, Garcia-Rodriguez C, Geren I, Lou J, Marks JD, Nakagawa T, Montal M. Molecular architecture of botulinum neurotoxin E revealed by single particle electron microscopy. J Biol Chem. 2008 Feb 15; 283(7):3997-4003. PMID: 18032388.
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    40. Tang Y, Lou J, Alpaugh RK, Robinson MK, Marks JD, Weiner LM. Regulation of antibody-dependent cellular cytotoxicity by IgG intrinsic and apparent affinity for target antigen. J Immunol. 2007 Sep 01; 179(5):2815-23. PMID: 17709495.
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    41. James D Marks, Peter Amersdorfer, Isin Geren, Jianlong Lou, Ali Razai, Consuelos Maria Garcia. THERAPEUTIC MONOCLONAL ANTIBODIES THAT NEUTRALIZE BOTULINUM NEUROTOXINS. 2007.
    42. Garcia-Rodriguez C, Levy R, Arndt JW, Forsyth CM, Razai A, Lou J, Geren I, Stevens RC, Marks JD. Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin. Nat Biotechnol. 2007 Jan; 25(1):107-16. PMID: 17173035.
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    43. Kehoe JW, Velappan N, Walbolt M, Rasmussen J, King D, Lou J, Knopp K, Pavlik P, Marks JD, Bertozzi CR, Bradbury AR. Using phage display to select antibodies recognizing post-translational modifications independently of sequence context. Mol Cell Proteomics. 2006 Dec; 5(12):2350-63. PMID: 16971384.
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    44. Varnum SM, Warner MG, Dockendorff B, Anheier NC, Lou J, Marks JD, Smith LA, Feldhaus MJ, Grate JW, Bruckner-Lea CJ. Enzyme-amplified protein microarray and a fluidic renewable surface fluorescence immunoassay for botulinum neurotoxin detection using high-affinity recombinant antibodies. Anal Chim Acta. 2006 Jun 16; 570(2):137-43. PMID: 17723391.
      View in: PubMed
    45. Horak E, Heitner T, Robinson MK, Simmons HH, Garrison J, Russeva M, Furmanova P, Lou J, Zhou Y, Yuan QA, Weiner LM, Adams GP, Marks JD. Isolation of scFvs to in vitro produced extracellular domains of EGFR family members. Cancer Biother Radiopharm. 2005 Dec; 20(6):603-13. PMID: 16398612.
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    46. Smith TJ, Lou J, Geren IN, Forsyth CM, Tsai R, Laporte SL, Tepp WH, Bradshaw M, Johnson EA, Smith LA, Marks JD. Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization. Infect Immun. 2005 Sep; 73(9):5450-7. PMID: 16113261; PMCID: PMC1231122.
    47. Razai A, Garcia-Rodriguez C, Lou J, Geren IN, Forsyth CM, Robles Y, Tsai R, Smith TJ, Smith LA, Siegel RW, Feldhaus M, Marks JD. Molecular evolution of antibody affinity for sensitive detection of botulinum neurotoxin type A. J Mol Biol. 2005 Aug 05; 351(1):158-69. PMID: 16002090.
      View in: PubMed
    48. Weaver-Feldhaus JM, Lou J, Coleman JR, Siegel RW, Marks JD, Feldhaus MJ. Yeast mating for combinatorial Fab library generation and surface display. FEBS Lett. 2004 Apr 23; 564(1-2):24-34. PMID: 15094038.
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    49. Bradbury A, Velappan N, Verzillo V, Ovecka M, Chasteen L, Sblattero D, Marzari R, Lou J, Siegel R, Pavlik P. Antibodies in proteomics II: screening, high-throughput characterization and downstream applications. Trends Biotechnol. 2003 Jul; 21(7):312-7. PMID: 12837616.
      View in: PubMed
    50. Bradbury A, Velappan N, Verzillo V, Ovecka M, Chasteen L, Sblattero D, Marzari R, Lou J, Siegel R, Pavlik P. Antibodies in proteomics I: generating antibodies. Trends Biotechnol. 2003 Jun; 21(6):275-81. PMID: 12788548.
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    51. Lou J, Marzari R, Verzillo V, Ferrero F, Pak D, Sheng M, Yang C, Sblattero D, Bradbury A. Antibodies in haystacks: how selection strategy influences the outcome of selection from molecular diversity libraries. J Immunol Methods. 2001 Jul 01; 253(1-2):233-42. PMID: 11384684.
      View in: PubMed
    52. Sblattero D, Lou J, Marzari R, Bradbury A. In vivo recombination as a tool to generate molecular diversity in phage antibody libraries. J Biotechnol. 2001 Jun; 74(4):303-15. PMID: 11526909.
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    53. Lou J . Applied Biotoxin and Toxicology , Chen Ning Qing, Meng Zhao He( Eds),. Sterigmatocystin. 2001; 311-329.
    54. Lou J . Modern Microbiology and Toxicology Jiao Bing Hua, Xie Zheng Yang( Eds). Sterigmatocystin. 2000; 374-383.
    55. Feng J, Ci YX, Lou J, Zhang XQ. Voltammetric behavior of mammalian tumor cells and bioanalytical applications in cell metabolism. Bioelectrochem Bioenerg. 1999 Feb; 48(1):217-22. PMID: 10228590.
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    56. Jun Feng, Ti Yu Gao, Jian Long Lou, Yun Xiang Ci and Zhen Quan Guo. Electromagnetic Biology and Medicine. Electrochemical Voltammetric Features in Living Tissues of MICE. 1999; 18(3):317-323.
    57. Lou J, Guo ZQ, Meng ZH. Production and characterization of a monoclonal antibody against sterigmatocystin. Biomed Environ Sci. 1996 Mar; 9(1):17-25. PMID: 8721623.
      View in: PubMed
    58. Meng Zhao He, Lou J, Guo Zhen Quan, Tian He Jing, and Liu Zhao Qian. Tumor in China. The Correlation of Sterigmatocystin and Human Cancer. 1996; 5(8):26-27.
    59. Lou J, Wang Y, Wang D, Meng Z. [Production and characterization of sterigmatocystin]. Wei Sheng Wu Xue Bao. 1995 Oct; 35(5):358-63. PMID: 8701584.
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    60. Tian H, Lou J, Du C. [Determination of sterigmatocystin in cancerous tissues, blood and urine in patients with liver and stomach cancer]. Zhonghua Yu Fang Yi Xue Za Zhi. 1995 Sep; 29(5):276-8. PMID: 8556937.
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    61. Lou J, Guo Z, Meng Z. [Preparation and identification of monoclonal antibody against sterigmatocystin]. Zhonghua Yu Fang Yi Xue Za Zhi. 1995 Mar; 29(2):92-5. PMID: 7796690.
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    62. Lou J, Meng ZH, Wang DS. Production and characterization of sterigmatocystin. Biomed Environ Sci. 1994 Dec; 7(4):293-301. PMID: 7702759.
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    63. Lou J, Meng Zhaohe. Journal of Hygiene Research. Screening of sterigmatocystin-producing aspergillus strains. 1993; 22(5):299-302.
    64. Lou J, Meng Zhao He. Progress in Sterigmatocystin Research. 1992.
    65. Lou J, Meng Zhao He. Medical Science Abroad. Progress in Sterigmatocystin Research. 1992; 19(4):218-221.
    66. Lou J, Zou Kang Nan. Chinese Journal of Public Health. Production and Application of Antibody against Sterigmatocystin. 1991; 10(6):367-370.
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