Jim Wells, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1700 4th St
San Francisco CA 94158
Phone415-514-4498
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    Other Positions
    Title(s)Chair, Pharmaceutical Chemistry


    Collapse Biography 
    Collapse Awards and Honors
    1979  - 1981Damon M. Runyon-Walter Winchell Postdoctoral Fellowship
    American Cancer Society1990Pfizer Award for achievements in enzyme chemistry
    Perdue University1991Joseph Foster Award Lecturer
    Washington State University1992Alumni Achievement Award
    Temple University1994Distinguished Award Lecture
    Rockefeller University1995Stein Memorial Award Lecture
    SUNY Stony Brook1997Begelsteil Award Lecture
    1997Frontiers in Biological Sciences Lecture, Case Western Reserve
    Washington State University1997Distinguished Alumni Award
    Protein Society1998Christian B. Anfinsin Awar
    American Peptide Society1998Vincent du Vignead Award
    NAS1999Elected Member to the National Academy of Sciences
    Protein Society2003Hans Neurath Award
    Harvard Medical School2005Otto Krayer Lectureship
    Boston College2005Boston College Distinguished Lectureship in Chemistry
    Stanford University2005Cutting Award Lecture
    2005Braisted Award Lecture
    American Cancer Society, Biotech2006Perlman Lecture Award of the ACS Biotechnology Division
    Nature Biotechnology2006Shortlisted Nominee, Nature Biotechnology’s Who’s Who in Biotech, most significant contribution to b
    CABM, Rutgers University2006Paul Janssen Prize in Adv. Biotech and Medicine
    Yale University2007Fred Richards Distinguished Lecture
    Rockefeller University2008Jane Darnell Distinguished Lecture
    Johns Hopkins University2009Kossiakoff Lecture in Biophysics
    University of Chicago2009Herman S. Bloch Award, “for scientific excellence in industry”
    Thomas Jefferson University2009Weinhouse Lecture in Biochemistry
    ASBMB2010Merck Award
    American Cancer Society2011Smissman Award in Medicinal Chemistry
    University of Illinois2011Ada Doisy Lectures
    Washington University, St Louis2011Carl and Gerty Cori Lecture
    University of Wisconsin, Madison2011Green Lecture
    St Luke's, Boise ID2011Burkholder Award Lecture
    Vanderbilt University, TN2012Lubomir S. Hnilica Endowed Lecture
    University of Washington, Seattle2012Gordon Lecture
    Gladstone, San Francisco2012Keynote at Gladstone Scientific Retreat
    UCSC Department of Chemistry and Biochemistry2013Keynote Speaker
    ICSB and Kyoto University2013Keynote Speaker at ICSB Meeting
    Tsinghua University2013Keynote Speaker, Symposium of Frontier Sciences on New Drug Discovery
    American Academy of Arts and Sciences2015Elected Member of Academy

    Collapse Overview 
    Collapse Overview
    James "Jim" Wells focuses on understanding and modulating signaling processes in human cells through protein and small molecule design. His lab seeks activators as well as inhibitors of signaling molecules, including proteases and kinases, and uses them to study the consequences of triggering specific nodes of signaling circuits. He is especially interested in the inter-protein circuitry of pathways involved in cell death and inflammation, and the intra-protein allosteric circuitry that governs how distant functional sites in one protein communicate.

    Collapse Research 
    Collapse Research Activities and Funding
    Antibody Research Technology Center
    NIH P41CA196276Sep 24, 2014 - Aug 31, 2019
    Role: Co-Investigator
    Affinity-directed tagging of protein binding partners in signaling
    NIH R01CA191018Jun 16, 2014 - May 31, 2019
    Role: Principal Investigator
    Generation of recombinant thiopeptides to target antimicrobial-resistant bacteria
    NIH R21AI111662Mar 1, 2014 - Feb 29, 2016
    Role: Principal Investigator
    Automated System for High-Throughput In Vitro Selection of Recombinant Antibodies
    NIH S10OD012037May 15, 2012 - May 14, 2014
    Role: Principal Investigator
    Regulating Proteolysis to Dissect Apoptosis
    NIH R01GM097316Sep 20, 2011 - Jun 30, 2015
    Role: Principal Investigator
    Approaches to discover and quantify apoptotic biomarkers for cancer treatment
    NIH R01CA154802Feb 1, 2011 - Jan 31, 2015
    Role: Principal Investigator
    Start-up Funds for Junior Faculty in Chemical Biology Group at UCSF
    NIH P30GM092427Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    High-throughput SPR Instrument for Small Molecule Discovery
    NIH S10RR025448Jan 1, 2009 - Dec 31, 2009
    Role: Principal Investigator
    Direct Chemical Activators of Caspases
    NIH R01CA136779Dec 5, 2008 - Nov 30, 2014
    Role: Principal Investigator
    Global Analysis of Proteolysis in Apoptosis
    NIH R01GM081051Apr 1, 2007 - Jul 31, 2016
    Role: Principal Investigator
    Site-specific Allosteric Inhibitors for Inflammatory Caspases
    NIH R01AI070292Mar 15, 2007 - Feb 28, 2013
    Role: Principal Investigator
    Activators of Procaspase-7
    NIH R21NS057022Jul 20, 2006 - Jul 19, 2007
    Role: Principal Investigator
    New Advances in Drug Discovery
    NIH R13CA098965Jan 13, 2003 - Dec 31, 2003
    Role: Principal Investigator
    HIV Integrase Drug Discovery Using Tethering Technology
    NIH R43AI052630Jul 1, 2002 - Jun 30, 2004
    Role: Principal Investigator
    FRET METHOD FOR IDENTIFYING HORMONE ANTAGONISTS
    NIH R43CA083440Jul 16, 1999 - Jun 30, 2000
    Role: Principal Investigator
    SITE-DIRECTED DRUG DISCOVERY
    NIH R44CA085141Jul 1, 1999 - Feb 28, 2003
    Role: Principal Investigator
    METHOD FOR DRUG DISCOVERY USING FRAGMENT ASSEMBLY
    NIH R43CA085141Jul 1, 1999 - Jun 30, 2001
    Role: Principal Investigator
    CANCER INFORMATION MATERIALS FOR LOW LITERACY WOMEN
    NIH R43CA062794Sep 30, 1996 - Mar 29, 1997
    Role: Principal Investigator
    READABLE HIV PREVENTION MATERIALS FOR LOW-LITERACY WOMEN
    NIH R43HD030126Feb 1, 1993 - Jul 31, 1993
    Role: Principal Investigator
    AIDS RISK REDUCTION AND CONDOM USE IN A NATIONAL SAMPLE
    NIH R01HD026265Sep 1, 1989 - Oct 31, 1990
    Role: Principal Investigator
    ANALYSIS OF AIDS BEHAVIOR CHANGE IN A NATIONAL SAMPLE
    NIH R01MH045661Jul 1, 1989 - Jun 30, 1990
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease. Clin Cancer Res. 2022 07 15; 28(14):3066-3075. Zhao N, Chopra S, Trepka K, Wang YH, Sakhamuri S, Hooshdaran N, Kim H, Zhou J, Lim SA, Leung KK, Egusa EA, Zhu J, Zhang L, Foye A, Sriram R, Chan E, Seo Y, Feng FY, Small EJ, Chou J, Wells JA, Aggarwal R, Evans MJ. PMID: 35604681; PMCID: PMC9288514.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. Nat Commun. 2022 07 15; 13(1):4121. Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL, Martin TG, Shah N, Vandenberg S, Prakash S, Besse L, Driessen C, Posey AD, Mullins RD, Eyquem J, Wells JA, Wiita AP. PMID: 35840578; PMCID: PMC9287322.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein-Protein Interactions. J Am Chem Soc. 2022 07 27; 144(29):13218-13225. Jiang Z, Kuo YH, Zhong M, Zhang J, Zhou XX, Xing L, Wells JA, Wang Y, Arkin MR. PMID: 35819848; PMCID: PMC9335864.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability. Nat Chem Biol. 2022 07; 18(7):751-761. Li Z, Ferguson L, Deol KK, Roberts MA, Magtanong L, Hendricks JM, Mousa GA, Kilinc S, Schaefer K, Wells JA, Bassik MC, Goga A, Dixon SJ, Ingolia NT, Olzmann JA. PMID: 35637349.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation. Mol Cell Proteomics. 2022 07; 21(7):100247. Solomon PE, Kirkemo LL, Wilson GM, Leung KK, Almond MH, Sayles LC, Sweet-Cordero EA, Rosenberg OS, Coon JJ, Wells JA. PMID: 35594991; PMCID: PMC9212846.
      View in: PubMed   Mentions:    Fields:    
    6. Roadmap for Optimizing and Broadening Antibody-Based PROTACs for Degradation of Cell Surface Proteins. ACS Chem Biol. 2022 05 20; 17(5):1259-1268. Gramespacher JA, Cotton AD, Burroughs PWW, Seiple IB, Wells JA. PMID: 35481357.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. Cell-surface tethered promiscuous biotinylators enable comparative small-scale surface proteomic analysis of human extracellular vesicles and cells. Elife. 2022 03 08; 11. Kirkemo LL, Elledge SK, Yang J, Byrnes JR, Glasgow JE, Blelloch R, Wells JA. PMID: 35257663; PMCID: PMC8983049.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Switchable assembly and function of antibody complexes in vivo using a small molecule. Proc Natl Acad Sci U S A. 2022 03 01; 119(9). Martinko AJ, Simonds EF, Prasad S, Ponce A, Bracken CJ, Wei J, Wang YH, Chow TL, Huang Z, Evans MJ, Wells JA, Hill ZB. PMID: 35210365; PMCID: PMC8892515.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Engineering Antibodies Targeting p16 MHC-Peptide Complexes. ACS Chem Biol. 2022 03 18; 17(3):545-555. Rettko NJ, Campisi J, Wells JA. PMID: 35212540.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression. Mol Cell Proteomics. 2022 04; 21(4):100217. Byrnes JR, Weeks AM, Shifrut E, Carnevale J, Kirkemo L, Ashworth A, Marson A, Wells JA. PMID: 35217172; PMCID: PMC9006863.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers. J Clin Invest. 2022 02 15; 132(4). Lim SA, Zhou J, Martinko AJ, Wang YH, Filippova EV, Steri V, Wang D, Remesh SG, Liu J, Hann B, Kossiakoff AA, Evans MJ, Leung KK, Wells JA. PMID: 35166238; PMCID: PMC8843743.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Identifying and antagonizing the interactions between layilin and glycosylated collagens. Cell Chem Biol. 2022 04 21; 29(4):597-604.e7. Glasgow JE, Byrnes JR, Barbee SD, Moreau JM, Rosenblum MD, Wells JA. PMID: 35104453.
      View in: PubMed   Mentions:    Fields:    
    13. Response to Vaccination Against SARS-CoV-2 in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis With Renal Involvement. Front Med (Lausanne). 2021; 8:817845. Carruthers JE, Wells J, Gupta A, Kallon D, Cox A, Pina N, Yaqoob MM, Rajakariar R. PMID: 35127773; PMCID: PMC8811045.
      View in: PubMed   Mentions:
    14. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. Nat Cell Biol. 2022 01; 24(1):24-34. Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. PMID: 35027731; PMCID: PMC8820466.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction. Blood Adv. 2021 12 14; 5(23):4901-4909. Fong KP, Molnar KS, Agard N, Litvinov RI, Kim OV, Wells JA, Weisel JW, DeGrado WF, Bennett JS. PMID: 34570183; PMCID: PMC9153048.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. Phage-Based Profiling of Rare Single Cells Using Nanoparticle-Directed Capture. ACS Nano. 2021 12 28; 15(12):19202-19210. Ma Y, Chen K, Xia F, Atwal R, Wang H, Ahmed SU, Cardarelli L, Lui I, Duong B, Wang Z, Wells JA, Sidhu SS, Kelley SO. PMID: 34813293.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance. Front Immunol. 2021; 12:686439. Muller YD, Ferreira LMR, Ronin E, Ho P, Nguyen V, Faleo G, Zhou Y, Lee K, Leung KK, Skartsis N, Kaul AM, Mulder A, Claas FHJ, Wells JA, Bluestone JA, Tang Q. PMID: 34616392; PMCID: PMC8488356.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    18. BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2. bioRxiv. 2021 Sep 20. Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman JS, Wells JA, Conklin BR, TenOever BR, Chakrabarti LA, Vignuzzi M, Tian R, Kampmann M. PMID: 33501440; PMCID: PMC7836110.
      View in: PubMed   Mentions:
    19. Biotin as a Reactive Handle to Selectively Label Proteins and DNA with Small Molecules. ACS Chem Biol. 2021 Aug 19. Cotton AD, Wells JA, Seiple IB. PMID: 34410115.
      View in: PubMed   Mentions:    Fields:    
    20. A functional mammalian display screen identifies rare antibodies that stimulate NK cell-mediated cytotoxicity. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). Kang E, Kadoch C, Rubenstein JL, Lanier LL, Wells JA. PMID: 34330834; PMCID: PMC8346823.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay. Sci Adv. 2021 Jul; 7(31). Peluso MJ, Takahashi S, Hakim J, Kelly JD, Torres L, Iyer NS, Turcios K, Janson O, Munter SE, Thanh C, Donatelli J, Nixon CC, Hoh R, Tai V, Fehrman EA, Hernandez Y, Spinelli MA, Gandhi M, Palafox MA, Vallari A, Rodgers MA, Prostko J, Hackett J, Trinh L, Wrin T, Petropoulos CJ, Chiu CY, Norris PJ, DiGermanio C, Stone M, Busch MP, Elledge SK, Zhou XX, Wells JA, Shu A, Kurtz TW, Pak JE, Wu W, Burbelo PD, Cohen JI, Rutishauser RL, Martin JN, Deeks SG, Henrich TJ, Rodriguez-Barraquer I, Greenhouse B. PMID: 34330709; PMCID: PMC8324059.
      View in: PubMed   Mentions: 36     Fields:    
    22. Real world utilization of REGEN-COV2 at a community hospital. Am J Emerg Med. 2021 Dec; 50:129-131. Ash J, Leavitt R, Dietrich T, Schritter S, Wells J, Santarelli A, Ashurst J. PMID: 34364110; PMCID: PMC8313789.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody that Targets two Distinct Epitopes on αv Integrins. J Mol Biol. 2021 07 23; 433(15):167090. Gallo E, Kelil A, Haughey M, Cazares-Olivera M, Yates BP, Zhang M, Wang NY, Blazer L, Carderelli L, Adams JJ, Kossiakoff AA, Wells JA, Xie W, Sidhu SS. PMID: 34090922.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    24. Reply to Liu et al.: Specific mutations matter in specificity and catalysis in ACE2. Proc Natl Acad Sci U S A. 2021 04 13; 118(15). Glasgow J, Glasgow A, Kortemme T, Wells JA. PMID: 33833059; PMCID: PMC8053976.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    25. Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. Nat Biotechnol. 2021 08; 39(8):928-935. Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer NS, Torres L, Peluso MJ, Henrich TJ, Wang TT, Tato CM, Leung KK, Greenhouse B, Wells JA. PMID: 33767397; PMCID: PMC8355051.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    26. The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28. Front Immunol. 2021; 12:639818. Muller YD, Nguyen DP, Ferreira LMR, Ho P, Raffin C, Valencia RVB, Congrave-Wilson Z, Roth TL, Eyquem J, Van Gool F, Marson A, Perez L, Wells JA, Bluestone JA, Tang Q. PMID: 33833759; PMCID: PMC8021955.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    27. SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay. medRxiv. 2021 Mar 05. Peluso MJ, Takahashi S, Hakim J, Kelly JD, Torres L, Iyer NS, Turcios K, Janson O, Munter SE, Thanh C, Nixon CC, Hoh R, Tai V, Fehrman EA, Hernandez Y, Spinelli MA, Gandhi M, Palafox MA, Vallari A, Rodgers MA, Prostko J, Hackett J, Trinh L, Wrin T, Petroplolous CJ, Chiu CY, Norris PJ, DiGermanio C, Stone M, Busch MP, Elledge SK, Zhou XX, Wells JA, Shu A, Kurtz TW, Pak JE, Wu W, Burbelo PD, Cohen JI, Rutishauser RL, Martin JN, Deeks SG, Henrich TJ, Rodriguez-Barraquer I, Greenhouse B. PMID: 33688675; PMCID: PMC7941652.
      View in: PubMed   Mentions: 2  
    28. Mapping proteolytic neo-N termini at the surface of living cells. Proc Natl Acad Sci U S A. 2021 02 23; 118(8). Weeks AM, Byrnes JR, Lui I, Wells JA. PMID: 33536314; PMCID: PMC7923363.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    29. The seroprevalence of SARS-CoV-2 in a rural southwest community. J Osteopath Med. 2021 Feb 01; 121(2):199-210. Santarelli A, Lalitsasivimol D, Bartholomew N, Reid S, Reid J, Lyon C, Wells J, Ashurst J. PMID: 33567087.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    30. Large remodeling of the Myc-induced cell surface proteome in B cells and prostate cells creates new opportunities for immunotherapy. Proc Natl Acad Sci U S A. 2021 01 26; 118(4). Chen W, Mou KY, Solomon P, Aggarwal R, Leung KK, Wells JA. PMID: 33483421; PMCID: PMC7848737.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1. J Am Chem Soc. 2021 01 20; 143(2):593-598. Cotton AD, Nguyen DP, Gramespacher JA, Seiple IB, Wells JA. PMID: 33395526; PMCID: PMC8154509.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    32. Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2. MAbs. 2021 Jan-Dec; 13(1):1893426. Lim SA, Gramespacher JA, Pance K, Rettko NJ, Solomon P, Jin J, Lui I, Elledge SK, Liu J, Bracken CJ, Simmons G, Zhou XX, Leung KK, Wells JA. PMID: 33666135; PMCID: PMC7939556.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    33. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28046-28055. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 33093202; PMCID: PMC7668070.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    34. Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2. Nat Chem Biol. 2021 01; 17(1):113-121. Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium, Zhou XX, Leung KK, Wells JA. PMID: 33082574; PMCID: PMC8356808.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    35. Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps. J Am Chem Soc. 2020 10 14; 142(41):17703-17713. Zhou XX, Bracken CJ, Zhang K, Zhou J, Mou Y, Wang L, Cheng Y, Leung KK, Wells JA. PMID: 32924468; PMCID: PMC8168474.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    36. ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens. Cell Rep Med. 2020 10 20; 1(7):100123. Zamecnik CR, Rajan JV, Yamauchi KA, Mann SA, Loudermilk RP, Sowa GM, Zorn KC, Alvarenga BD, Gaebler C, Caskey M, Stone M, Norris PJ, Gu W, Chiu CY, Ng D, Byrnes JR, Zhou XX, Wells JA, Robbiani DF, Nussenzweig MC, DeRisi JL, Wilson MR. PMID: 32995758; PMCID: PMC7513813.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    37. Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25464-25475. Zhou J, Li S, Leung KK, O'Donovan B, Zou JY, DeRisi JL, Wells JA. PMID: 32973096; PMCID: PMC7568340.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    38. Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding. mSphere. 2020 09 16; 5(5). Byrnes JR, Zhou XX, Lui I, Elledge SK, Glasgow JE, Lim SA, Loudermilk RP, Chiu CY, Wang TT, Wilson MR, Leung KK, Wells JA. PMID: 32938700; PMCID: PMC7494835.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCellsPHPublic Health
    39. Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. medRxiv. 2020 Aug 21. Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer N, Torres L, Peluso MJ, Henrich TJ, Wang TT, Tato CM, Leung KK, Greenhouse B, Wells JA. PMID: 32839788; PMCID: PMC7444307.
      View in: PubMed   Mentions: 1  
    40. Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike. bioRxiv. 2020 Aug 10. Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium, Zhou XX, Leung KK, Wells JA. PMID: 32817948; PMCID: PMC7430580.
      View in: PubMed   Mentions:
    41. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. bioRxiv. 2020 Aug 04. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 32766586; PMCID: PMC7402043.
      View in: PubMed   Mentions:
    42. ATAD5 restricts R-loop formation through PCNA unloading and RNA helicase maintenance at the replication fork. Nucleic Acids Res. 2020 07 27; 48(13):7218-7238. Kim S, Kang N, Park SH, Wells J, Hwang T, Ryu E, Kim BG, Hwang S, Kim SJ, Kang S, Lee S, Stirling P, Myung K, Lee KY. PMID: 32542338; PMCID: PMC7367208.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    43. Redox priming promotes Aurora A activation during mitosis. Sci Signal. 2020 07 21; 13(641). Lim DC, Joukov V, Rettenmaier TJ, Kumagai A, Dunphy WG, Wells JA, Yaffe MB. PMID: 32694171; PMCID: PMC8514121.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    44. Split enzymes: Design principles and strategy. Methods Enzymol. 2020; 644:275-296. Lim SA, Wells JA. PMID: 32943149.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    45. A SARS-CoV-2 serological assay to determine the presence of blocking antibodies that compete for human ACE2 binding. medRxiv. 2020 May 29. Byrnes JR, Zhou XX, Lui I, Elledge SK, Glasgow JE, Lim SA, Loudermilk R, Chiu CY, Wilson MR, Leung KK, Wells JA. PMID: 32511506; PMCID: PMC7273274.
      View in: PubMed   Mentions:
    46. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chem Biol. 2020 06 18; 27(6):647-656.e6. Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, Walensky LD. PMID: 32413285; PMCID: PMC7405809.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    47. Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer. Clin Cancer Res. 2020 07 15; 26(14):3608-3615. Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhuo J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, Kirkwood KS, Wells JA, Evans MJ. PMID: 32341034; PMCID: PMC7367754.
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    48. National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions. J Proteome Res. 2020 05 01; 19(5):1900-1912. Kagan J, Moritz RL, Mazurchuk R, Lee JH, Kharchenko PV, Rozenblatt-Rosen O, Ruppin E, Edfors F, Ginty F, Goltsev Y, Wells JA, LaCava J, Riesterer JL, Germain RN, Shi T, Chee MS, Budnik BA, Yates JR, Chait BT, Moffitt JR, Smith RD, Srivastava S. PMID: 32163288.
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    49. Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7764-7775. Leung KK, Wilson GM, Kirkemo LL, Riley NM, Coon JJ, Wells JA. PMID: 32205440; PMCID: PMC7148585.
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    50. Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):5733-5740. Elledge SK, Tran HL, Christian AH, Steri V, Hann B, Toste FD, Chang CJ, Wells JA. PMID: 32123103; PMCID: PMC7084160.
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    51. N-Terminal Modification of Proteins with Subtiligase Specificity Variants. Curr Protoc Chem Biol. 2020 03; 12(1):e79. Weeks AM, Wells JA. PMID: 32074409.
      View in: PubMed   Mentions: 3     Fields:    
    52. Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling. Mol Cell Proteomics. 2020 02; 19(2):294-307. Wei J, Leung K, Truillet C, Ruggero D, Wells JA, Evans MJ. PMID: 31792071; PMCID: PMC7000124.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    53. Subtiligase-Catalyzed Peptide Ligation. Chem Rev. 2020 03 25; 120(6):3127-3160. Weeks AM, Wells JA. PMID: 31663725.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    54. Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases. J Med Chem. 2019 07 25; 62(14):6512-6524. Yueh C, Rettenmaier J, Xia B, Hall DR, Alekseenko A, Porter KA, Barkovich K, Keseru G, Whitty A, Wells JA, Vajda S, Kozakov D. PMID: 31274316; PMCID: PMC7019049.
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    55. Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration. Neuron. 2019 08 07; 103(3):412-422.e4. Hertz NT, Adams EL, Weber RA, Shen RJ, O'Rourke MK, Simon DJ, Zebroski H, Olsen O, Morgan CW, Mileur TR, Hitchcock AM, Sinnott Armstrong NA, Wainberg M, Bassik MC, Molina H, Wells JA, Tessier-Lavigne M. PMID: 31221560; PMCID: PMC8024238.
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    56. Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome. Proc Natl Acad Sci U S A. 2019 01 08; 116(2):695-700. Leung KK, Nguyen A, Shi T, Tang L, Ni X, Escoubet L, MacBeth KJ, DiMartino J, Wells JA. PMID: 30584089; PMCID: PMC6329958.
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    57. Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif. J Am Chem Soc. 2018 12 05; 140(48):16615-16624. Mou Y, Zhou XX, Leung K, Martinko AJ, Yu JY, Chen W, Wells JA. PMID: 30398859.
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    58. Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):8960-8965. Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL, Fierke CA, Mapp AK. PMID: 30127017; PMCID: PMC6130367.
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    59. The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins. ACS Chem Biol. 2018 09 21; 13(9):2398-2405. Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA. PMID: 30080377.
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    60. An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife. 2018 06 07; 7. Keedy DA, Hill ZB, Biel JT, Kang E, Rettenmaier TJ, Brandão-Neto J, Pearce NM, von Delft F, Wells JA, Fraser JS. PMID: 29877794; PMCID: PMC6039181.
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    61. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 05 07; 15(5):2054-2059. Spangler B, Kline T, Hanson J, Li X, Zhou S, Wells JA, Sato AK, Renslo AR. PMID: 29569925.
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    62. Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. Proc Natl Acad Sci U S A. 2018 03 13; 115(11):2836-2841. Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA. PMID: 29476010; PMCID: PMC5856557.
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    63. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 Mar; 25(3):486-541. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. PMID: 29362479; PMCID: PMC5864239.
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    64. Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. Elife. 2018 01 23; 7. Martinko AJ, Truillet C, Julien O, Diaz JE, Horlbeck MA, Whiteley G, Blonder J, Weissman JS, Bandyopadhyay S, Evans MJ, Wells JA. PMID: 29359686; PMCID: PMC5796798.
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    65. Human antibody-based chemically induced dimerizers for cell therapeutic applications. Nat Chem Biol. 2018 02; 14(2):112-117. Hill ZB, Martinko AJ, Nguyen DP, Wells JA. PMID: 29200207; PMCID: PMC6352901.
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    66. Engineering peptide ligase specificity by proteomic identification of ligation sites. Nat Chem Biol. 2018 Jan; 14(1):50-57. Weeks AM, Wells JA. PMID: 29155430; PMCID: PMC5726896.
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    67. Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades. Mol Cancer Res. 2018 01; 16(1):58-68. Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett CS, Gestwicki JE. PMID: 28970360; PMCID: PMC6101036.
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    68. A Split-Abl Kinase for Direct Activation in Cells. Cell Chem Biol. 2017 Oct 19; 24(10):1250-1258.e4. Diaz JE, Morgan CW, Minogue CE, Hebert AS, Coon JJ, Wells JA. PMID: 28919041; PMCID: PMC5650542.
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    69. Engineering a light-activated caspase-3 for precise ablation of neurons in vivo. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8174-E8183. Smart AD, Pache RA, Thomsen ND, Kortemme T, Davis GW, Wells JA. PMID: 28893998; PMCID: PMC5625904.
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    70. Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics. Cell Syst. 2017 06 28; 4(6):636-644.e9. Liu TY, Huang HH, Wheeler D, Xu Y, Wells JA, Song YS, Wiita AP. PMID: 28578850; PMCID: PMC5546878.
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    71. Caspases and their substrates. Cell Death Differ. 2017 08; 24(8):1380-1389. Julien O, Wells JA. PMID: 28498362; PMCID: PMC5520456.
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    72. Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product. J Am Chem Soc. 2017 02 22; 139(7):2541-2544. Tran HL, Lexa KW, Julien O, Young TS, Walsh CT, Jacobson MP, Wells JA. PMID: 28170244; PMCID: PMC5345905.
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    73. Redox-based reagents for chemoselective methionine bioconjugation. Science. 2017 02 10; 355(6325):597-602. Lin S, Yang X, Jia S, Weeks AM, Hornsby M, Lee PS, Nichiporuk RV, Iavarone AT, Wells JA, Toste FD, Chang CJ. PMID: 28183972; PMCID: PMC5827972.
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    74. Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast. Mol Cell Proteomics. 2017 04; 16(4):512-523. Calvo SE, Julien O, Clauser KR, Shen H, Kamer KJ, Wells JA, Mootha VK. PMID: 28122942; PMCID: PMC5383775.
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    75. Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface. Oncotarget. 2016 Dec 27; 7(52):86948-86971. Ye X, Chan KC, Waters AM, Bess M, Harned A, Wei BR, Loncarek J, Luke BT, Orsburn BC, Hollinger BD, Stephens RM, Bagni R, Martinko A, Wells JA, Nissley DV, McCormick F, Whiteley G, Blonder J. PMID: 27894102; PMCID: PMC5341332.
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    76. A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models. J Med Chem. 2016 12 22; 59(24):11161-11170. Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR. PMID: 27936709; PMCID: PMC5184369.
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    77. Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase. J Am Chem Soc. 2016 10 12; 138(40):13123-13126. Hill ZB, Pollock SB, Zhuang M, Wells JA. PMID: 27626304; PMCID: PMC5308480.
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    78. Enzyme-catalyzed expressed protein ligation. Nat Methods. 2016 Nov; 13(11):925-927. Henager SH, Chu N, Chen Z, Bolduc D, Dempsey DR, Hwang Y, Wells J, Cole PA. PMID: 27669326; PMCID: PMC5088058.
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    79. Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9587-92. Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T, Ju S, Fisher OS, Miller DW, Datta D, Wu F, Wu CX, Landeru A, Wells JA, Cookson MR, Boxer MB, Thomas CJ, Gai WP, Ringe D, Petsko GA, Hoang QQ. PMID: 27482083; PMCID: PMC5003239.
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    80. Stem Cells and Regeneration in the Digestive System: Keystone Meeting. Gastroenterology. 2016 09; 151(3):e6-9. Soffers JH, Hansen D, Sinagoga KL, Li B, Martin MG, Wells J, Grompe M, Li L. PMID: 27480172; PMCID: PMC6044286.
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    81. A reactivity-based probe of the intracellular labile ferrous iron pool. Nat Chem Biol. 2016 09; 12(9):680-5. Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, Renslo AR. PMID: 27376690; PMCID: PMC4990480.
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    82. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity. Nat Commun. 2016 07 01; 7:12009. Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA. PMID: 27363581; PMCID: PMC4932181.
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    83. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. ACS Chem Biol. 2016 06 17; 11(6):1603-12. Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA. PMID: 27032039; PMCID: PMC4912419.
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    84. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):E2001-10. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. PMID: 27006500; PMCID: PMC4833263.
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    85. Initial Results from the Survey of Organizational Research Climates (SOuRCe) in the U.S. Department of Veterans Affairs Healthcare System. PLoS One. 2016; 11(3):e0151571. Martinson BC, Nelson D, Hagel-Campbell E, Mohr D, Charns MP, Bangerter A, Thrush CR, Ghilardi JR, Bloomfield H, Owen R, Wells JA. PMID: 26967736; PMCID: PMC4788347.
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    86. CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites. J Mol Biol. 2016 Feb 22; 428(4):709-719. Cimermancic P, Weinkam P, Rettenmaier TJ, Bichmann L, Keedy DA, Woldeyes RA, Schneidman-Duhovny D, Demerdash ON, Mitchell JC, Wells JA, Fraser JS, Sali A. PMID: 26854760; PMCID: PMC4794384.
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    87. Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking. J Med Chem. 2015 Oct 22; 58(20):8285-8291. Rettenmaier TJ, Fan H, Karpiak J, Doak A, Sali A, Shoichet BK, Wells JA. PMID: 26443011; PMCID: PMC5099076.
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    88. A High Through-put Platform for Recombinant Antibodies to Folded Proteins. Mol Cell Proteomics. 2015 Oct; 14(10):2833-47. Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, Hoey RJ, Lai D, Griffin C, Li Z, Vizeacoumar FJ, Dong D, Campbell E, Anderson S, Zhong N, Gräslund S, Koide S, Moffat J, Sidhu S, Kossiakoff A, Wells J. PMID: 26290498; PMCID: PMC4597156.
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    89. Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8344-9. Morgan CW, Diaz JE, Zeitlin SG, Gray DC, Wells JA. PMID: 26106156; PMCID: PMC4500269.
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    90. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18590-5. Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. PMID: 25518860; PMCID: PMC4284534.
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    91. An improved single-chain Fab platform for efficient display and recombinant expression. J Mol Biol. 2015 Jan 30; 427(2):576-86. Koerber JT, Hornsby MJ, Wells JA. PMID: 25481745; PMCID: PMC4297586.
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    92. In amnio MRI of mouse embryos. PLoS One. 2014; 9(10):e109143. Roberts TA, Norris FC, Carnaghan H, Savery D, Wells JA, Siow B, Scambler PJ, Pierro A, De Coppi P, Eaton S, Lythgoe MF. PMID: 25330230; PMCID: PMC4198080.
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    93. Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Mol Cell. 2014 Nov 06; 56(3):360-375. Ordureau A, Sarraf SA, Duda DM, Heo JM, Jedrychowski MP, Sviderskiy VO, Olszewski JL, Koerber JT, Xie T, Beausoleil SA, Wells JA, Gygi SP, Schulman BA, Harper JW. PMID: 25284222; PMCID: PMC4254048.
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    94. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Nov; 10(11):969-76. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. PMID: 25262416; PMCID: PMC4201873.
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    95. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. Chem Biol. 2014 Sep 18; 21(9):1102-14. Arkin MR, Tang Y, Wells JA. PMID: 25237857; PMCID: PMC4179228.
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    96. Cell biology. New tricks for an old dimer. Science. 2014 May 16; 344(6185):703-4. Wells JA, Kossiakoff AA. PMID: 24833381.
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    97. Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7594-9. Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA. PMID: 24821784; PMCID: PMC4040605.
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    98. FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions. Medchemcomm. 2014 Mar 01; 5:370-375. Lodge JM, Rettenmaier TJ, Wells JA, Pomerantz WC, Mapp AK. PMID: 24795804; PMCID: PMC4005387.
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    99. Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini. Methods Enzymol. 2014; 544:327-58. Wiita AP, Seaman JE, Wells JA. PMID: 24974296; PMCID: PMC4260929.
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    100. Methods in Enzymology. Regulated cell death part B--necroptotic, autophagic and other non-apoptotic mechanisms. Preface. Methods Enzymol. 2014; 545:xiii. Ashkenazi A, Wells JA, Yuan J. PMID: 25065895.
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    101. Turning on caspases with genetics and small molecules. Methods Enzymol. 2014; 544:179-213. Morgan CW, Julien O, Unger EK, Shah NM, Wells JA. PMID: 24974291; PMCID: PMC4249682.
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    102. Regulated cell death part A: apoptotic mechanisms. Preface. Methods Enzymol. 2014; 544:xv. Ashkenazi A, Yuan J, Wells JA. PMID: 24974300.
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    103. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28; 503(7477):548-51. Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. PMID: 24256730; PMCID: PMC4274051.
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    104. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013 Oct 29; 2:e01236. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. PMID: 24171104; PMCID: PMC3808542.
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    105. Nature-inspired design of motif-specific antibody scaffolds. Nat Biotechnol. 2013 Oct; 31(10):916-21. Koerber JT, Thomsen ND, Hannigan BT, Degrado WF, Wells JA. PMID: 23955275; PMCID: PMC3795957.
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    106. Next generation therapeutics. Curr Opin Chem Biol. 2013 Jun; 17(3):317-9. Carter PJ, Hazuda D, Wells JA. PMID: 23683350.
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    107. Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8477-82. Thomsen ND, Koerber JT, Wells JA. PMID: 23650375; PMCID: PMC3666719.
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    108. Ordering a dynamic protein via a small-molecule stabilizer. J Am Chem Soc. 2013 Mar 06; 135(9):3363-6. Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL, Wells JA, Mapp AK. PMID: 23384013; PMCID: PMC3607081.
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    109. Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. J Biol Chem. 2013 Apr 05; 288(14):9971-9981. Datta D, McClendon CL, Jacobson MP, Wells JA. PMID: 23386603; PMCID: PMC3617296.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    110. The DegraBase: a database of proteolysis in healthy and apoptotic human cells. Mol Cell Proteomics. 2013 Mar; 12(3):813-24. Crawford ED, Seaman JE, Agard N, Hsu GW, Julien O, Mahrus S, Nguyen H, Shimbo K, Yoshihara HA, Zhuang M, Chalkley RJ, Wells JA. PMID: 23264352; PMCID: PMC3591672.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    111. Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Mol Cell. 2013 Jan 24; 49(2):273-82. Zhuang M, Guan S, Wang H, Burlingame AL, Wells JA. PMID: 23201124; PMCID: PMC3557559.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    112. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Cell Death Differ. 2012 Dec; 19(12):2040-8. Crawford ED, Seaman JE, Barber AE, David DC, Babbitt PC, Burlingame AL, Wells JA. PMID: 22918439; PMCID: PMC3504717.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    113. Fibrils colocalize caspase-3 with procaspase-3 to foster maturation. J Biol Chem. 2012 Sep 28; 287(40):33781-95. Zorn JA, Wolan DW, Agard NJ, Wells JA. PMID: 22872644; PMCID: PMC3460474.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    114. Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12432-7. Shimbo K, Hsu GW, Nguyen H, Mahrus S, Trinidad JC, Burlingame AL, Wells JA. PMID: 22802652; PMCID: PMC3412033.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    115. Global kinetic analysis of proteolysis via quantitative targeted proteomics. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):1913-8. Agard NJ, Mahrus S, Trinidad JC, Lynn A, Burlingame AL, Wells JA. PMID: 22308409; PMCID: PMC3277568.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    116. Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair. J Orthop Res. 2012 Jul; 30(7):1095-102. Liu F, Porter RM, Wells J, Glatt V, Pilapil C, Evans CH. PMID: 22213093; PMCID: PMC3349003.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    117. Identification of specific tethered inhibitors for caspase-5. Chem Biol Drug Des. 2012 Feb; 79(2):209-15. Gao J, Wells JA. PMID: 22014003; PMCID: PMC3271850.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    118. Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. J Am Chem Soc. 2011 Dec 14; 133(49):19630-3. Zorn JA, Wille H, Wolan DW, Wells JA. PMID: 22066605; PMCID: PMC3253528.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    119. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J Biol Chem. 2011 Sep 30; 286(39):34147-54. Tang Y, Wells JA, Arkin MR. PMID: 21828056; PMCID: PMC3190824.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    120. Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6056-61. Sadowsky JD, Burlingame MA, Wolan DW, McClendon CL, Jacobson MP, Wells JA. PMID: 21430264; PMCID: PMC3076885.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    121. Caspase substrates and cellular remodeling. Annu Rev Biochem. 2011; 80:1055-87. Crawford ED, Wells JA. PMID: 21456965.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    122. Activation of specific apoptotic caspases with an engineered small-molecule-activated protease. Cell. 2010 Aug 20; 142(4):637-46. Gray DC, Mahrus S, Wells JA. PMID: 20723762; PMCID: PMC3689538.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    123. Prediction of protease substrates using sequence and structure features. Bioinformatics. 2010 Jul 15; 26(14):1714-22. Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A. PMID: 20505003; PMCID: PMC2894511.
      View in: PubMed   Mentions: 29     Fields:    
    124. Turning enzymes ON with small molecules. Nat Chem Biol. 2010 Mar; 6(3):179-188. Zorn JA, Wells JA. PMID: 20154666.
      View in: PubMed   Mentions: 90     Fields:    
    125. Inflammatory stimuli regulate caspase substrate profiles. Mol Cell Proteomics. 2010 May; 9(5):880-93. Agard NJ, Maltby D, Wells JA. PMID: 20173201; PMCID: PMC2871421.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    126. Sampling the N-terminal proteome of human blood. Proc Natl Acad Sci U S A. 2010 Mar 09; 107(10):4561-6. Wildes D, Wells JA. PMID: 20173099; PMCID: PMC2842036.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    127. Molecules that modulate Apaf-1 activity. Med Res Rev. 2011 Jul; 31(4):649-75. Pérez-Payá E, Orzáez M, Mondragón L, Wolan D, Wells JA, Messeguer A, Vicent MJ. PMID: 20099266.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    128. Warren L. DeLano 21 June 1972-3 November 2009. Nat Struct Mol Biol. 2009 Dec; 16(12):1202-3. Brunger AT, Wells JA. PMID: 19956203.
      View in: PubMed   Mentions: 2     Fields:    
    129. Small-molecule activators of a proenzyme. Science. 2009 Nov 06; 326(5954):853-8. Wolan DW, Zorn JA, Gray DC, Wells JA. PMID: 19892984; PMCID: PMC2886848.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    130. Methods for the proteomic identification of protease substrates. Curr Opin Chem Biol. 2009 Dec; 13(5-6):503-9. Agard NJ, Wells JA. PMID: 19729334; PMCID: PMC2787889.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    131. Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. J Biol Chem. 2009 Sep 18; 284(38):26063-9. Hardy JA, Wells JA. PMID: 19581639; PMCID: PMC2758006.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    132. Two-state selection of conformation-specific antibodies. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3071-6. Gao J, Sidhu SS, Wells JA. PMID: 19208804; PMCID: PMC2651286.
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    133. Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini. Cell. 2008 Sep 05; 134(5):866-76. Mahrus S, Trinidad JC, Barkan DT, Sali A, Burlingame AL, Wells JA. PMID: 18722006; PMCID: PMC2566540.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansCells
    134. Tags for labeling protein N-termini with subtiligase for proteomics. Bioorg Med Chem Lett. 2008 Nov 15; 18(22):6000-3. Yoshihara HA, Mahrus S, Wells JA. PMID: 18762420; PMCID: PMC2590642.
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    135. An allosteric circuit in caspase-1. J Mol Biol. 2008 Sep 19; 381(5):1157-67. Datta D, Scheer JM, Romanowski MJ, Wells JA. PMID: 18590738; PMCID: PMC2626611.
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    136. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature. 2007 Dec 13; 450(7172):1001-9. Wells JA, McClendon CL. PMID: 18075579.
      View in: PubMed   Mentions: 690     Fields:    Translation:HumansAnimalsCells
    137. Computational approach to site-directed ligand discovery. Proteins. 2007 Aug 01; 68(2):551-60. Tóth G, Mukhyala K, Wells JA. PMID: 17444517.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    138. Evaluation of technical approaches to tele-electromyography via internet protocol networks. Telemed J E Health. 2007 Feb; 13(1):33-9. Simmons SC, Moore DP, Wells J. PMID: 17309352.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    139. Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema. Arch Ophthalmol. 2006 Dec; 124(12):1701-7. Diabetic Retinopathy Clinical Research Network, Danis RP, Glassman AR, Aiello LP, Antoszyk AN, Beck RW, Browning DJ, Ciardella AP, Kinyoun JL, Murtha TJ, Topping TM, Shami M, Sharuk GS, Wells JA. PMID: 17159029; PMCID: PMC2279019.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    140. Hot-spot mimicry of a cytokine receptor by a small molecule. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15422-7. Thanos CD, DeLano WL, Wells JA. PMID: 17032757; PMCID: PMC1592646.
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    141. Positive pressure ventilation with the laryngeal mask airway in the operating room and prehospital: a practical review. J Trauma. 2006 Jun; 60(6):1371-6. Matioc AA, Wells JA. PMID: 16766989.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    142. A common allosteric site and mechanism in caspases. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7595-600. Scheer JM, Romanowski MJ, Wells JA. PMID: 16682620; PMCID: PMC1458511.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    143. Malonate-assisted purification of human caspases. Protein Expr Purif. 2005 May; 41(1):148-53. Scheer JM, Wells JA, Romanowski MJ. PMID: 15802232.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    144. Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2719-24. Buck E, Wells JA. PMID: 15710877; PMCID: PMC549436.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    145. Searching for new allosteric sites in enzymes. Curr Opin Struct Biol. 2004 Dec; 14(6):706-15. Hardy JA, Wells JA. PMID: 15582395.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    146. Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor. J Biol Chem. 2005 Feb 11; 280(6):4009-12. Buck E, Bourne H, Wells JA. PMID: 15550394.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    147. Discovery of an allosteric site in the caspases. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12461-6. Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA. PMID: 15314233; PMCID: PMC514654.
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    148. Apo cytochrome c inhibits caspases by preventing apoptosome formation. Biochem Biophys Res Commun. 2004 Jul 02; 319(3):944-50. Martin AG, Nguyen J, Wells JA, Fearnhead HO. PMID: 15184073.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    149. Mechanistic diversity of cytokine receptor signaling across cell membranes. Sci STKE. 2004 Apr 28; 2004(231):re7. Stroud RM, Wells JA. PMID: 15126678.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    150. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov. 2004 Apr; 3(4):301-17. Arkin MR, Wells JA. PMID: 15060526.
      View in: PubMed   Mentions: 511     Fields:    Translation:HumansAnimalsCells
    151. Tethering: fragment-based drug discovery. Annu Rev Biophys Biomol Struct. 2004; 33:199-223. Erlanson DA, Wells JA, Braisted AC. PMID: 15139811.
      View in: PubMed   Mentions: 114     Fields:    Translation:Cells
    152. Potent small-molecule binding to a dynamic hot spot on IL-2. J Am Chem Soc. 2003 Dec 17; 125(50):15280-1. Thanos CD, Randal M, Wells JA. PMID: 14664558.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    153. Propylene glycol-associated renal toxicity from lorazepam infusion. Pharmacotherapy. 2003 Sep; 23(9):1094-9. Yaucher NE, Fish JT, Smith HW, Wells JA. PMID: 14524641.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    154. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7533-8. Nguyen JT, Wells JA. PMID: 12808146; PMCID: PMC164621.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    155. Binding of small molecules to an adaptive protein-protein interface. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1603-8. Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. PMID: 12582206; PMCID: PMC149879.
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    156. Drug discovery at signaling interfaces. Ernst Schering Res Found Workshop. 2003; (42):19-27. Wells J, Arkin M, Braisted A, DeLano W, McDowell B, Oslob J, Raimundo B, Randal M. PMID: 12664533.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    157. BVA governance. Vet Rec. 2002 Aug 24; 151(8):247; author reply 247. Johnson B, Gorman NT, Hird JF, Wadsworth DE, Wells JA, Dyson SJ, Bleby J. PMID: 12219907.
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    158. Nocturnal polyuria in type 2 diabetes: a symptom of obstructive sleep apnea. Diabetes Educ. 2002 May-Jun; 28(3):424-34. Chasens ER, Umlauf MG, Pillion DJ, Wells JA. PMID: 12068651.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    159. The LMA-unique in a prehospital trauma patient: interaction with a semirigid cervical collar: a case report. J Trauma. 2002 Jan; 52(1):162-4. Matioc AA, Wells JA. PMID: 11791069.
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    160. Acute barium poisoning treated with hemodialysis. Am J Emerg Med. 2001 Mar; 19(2):175-7. Wells JA, Wood KE. PMID: 11239275.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    161. Metabolic databases - what next? Trends Biochem Sci. 2001 Feb; 26(2):137-40. Gerrard JA, Sparrow AD, Wells JA. PMID: 11166573.
      View in: PubMed   Mentions: 5     Fields:    
    162. Site-directed ligand discovery. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9367-72. Erlanson DA, Braisted AC, Raphael DR, Randal M, Stroud RM, Gordon EM, Wells JA. PMID: 10944209; PMCID: PMC16870.
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    163. Mutational analysis of the major coat protein of M13 identifies residues that control protein display. Protein Sci. 2000 Apr; 9(4):647-54. Weiss GA, Wells JA, Sidhu SS. PMID: 10794407; PMCID: PMC2144610.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    164. High copy display of large proteins on phage for functional selections. J Mol Biol. 2000 Feb 18; 296(2):487-95. Sidhu SS, Weiss GA, Wells JA. PMID: 10669603.
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    165. Convergent solutions to binding at a protein-protein interface. Science. 2000 Feb 18; 287(5456):1279-83. DeLano WL, Ultsch MH, de Vos AM, Wells JA. PMID: 10678837.
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    166. Phage display for selection of novel binding peptides. Methods Enzymol. 2000; 328:333-63. Sidhu SS, Lowman HB, Cunningham BC, Wells JA. PMID: 11075354.
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    167. Urinary incontinence in a geriatric patient with a complex neurologic history. J Wound Ostomy Continence Nurs. 1999 Sep; 26(5):270-4; discussion 274-5. Wells JA, Ouslander JG, Meadows E, Johnson VY. PMID: 10795211.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    168. Selection for improved subtiligases by phage display. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9497-502. Atwell S, Wells JA. PMID: 10449721; PMCID: PMC22237.
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    169. Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity. Biochemistry. 1999 Jan 05; 38(1):81-9. Pearce KH, Cunningham BC, Fuh G, Teeri T, Wells JA. PMID: 9890885.
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    170. Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site. Biochemistry. 1998 Dec 22; 37(51):17754-64. Fairbrother WJ, Christinger HW, Cochran AG, Fuh G, Keenan CJ, Quan C, Shriver SK, Tom JY, Wells JA, Cunningham BC. PMID: 9922141.
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    171. Probing the importance of second sphere residues in an esterolytic antibody by phage display. J Mol Biol. 1998 Dec 11; 284(4):1083-94. Arkin MR, Wells JA. PMID: 9837728.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    172. Will any dimer do? Nat Struct Biol. 1998 Nov; 5(11):938-40. Ballinger MD, Wells JA. PMID: 9808034.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    173. Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis. J Biol Chem. 1998 May 08; 273(19):11667-74. Jones JT, Ballinger MD, Pisacane PI, Lofgren JA, Fitzpatrick VD, Fairbrother WJ, Wells JA, Sliwkowski MX. PMID: 9565587.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    174. Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display. J Biol Chem. 1998 May 08; 273(19):11675-84. Ballinger MD, Jones JT, Lofgren JA, Fairbrother WJ, Akita RW, Sliwkowski MX, Wells JA. PMID: 9565588.
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    175. Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor. J Biol Chem. 1998 May 01; 273(18):11197-204. Fuh G, Li B, Crowley C, Cunningham B, Wells JA. PMID: 9556609.
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    176. Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity. J Mol Biol. 1998 Apr 17; 277(5):1111-28. Clackson T, Ultsch MH, Wells JA, de Vos AM. PMID: 9571026.
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    177. Interface pressure, wound healing, and satisfaction in the evaluation of a non-powered fluid mattress. Ostomy Wound Manage. 1998 Feb; 44(2):38-42, 44-6, 48 passim. Wells JA, Karr D. PMID: 9526420.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    178. Incidence of idiopathic full-thickness macular holes in fellow eyes. A 5-year prospective natural history study. Ophthalmology. 1998 Feb; 105(2):353-9. Ezra E, Wells JA, Gray RH, Kinsella FM, Orr GM, Grego J, Arden GB, Gregor ZJ. PMID: 9479299.
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    179. Surgical removal of non-age-related subfoveal choroidal neovascular membranes. Eye (Lond). 1998; 12 ( Pt 5):775-80. Eckstein M, Wells JA, Aylward B, Gregor Z. PMID: 10070507.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    180. Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor. Cell. 1997 Nov 28; 91(5):695-704. Wiesmann C, Fuh G, Christinger HW, Eigenbrot C, Wells JA, de Vos AM. PMID: 9393862.
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    181. Structural plasticity in a remodeled protein-protein interface. Science. 1997 Nov 07; 278(5340):1125-8. Atwell S, Ultsch M, De Vos AM, Wells JA. PMID: 9353194.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    182. Phage display of a catalytic antibody to optimize affinity for transition-state analog binding. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10063-8. Baca M, Scanlan TS, Stephenson RC, Wells JA. PMID: 9294163; PMCID: PMC23305.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    183. Structural mimicry of a native protein by a minimized binding domain. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10080-5. Starovasnik MA, Braisted AC, Wells JA. PMID: 9294166; PMCID: PMC23311.
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    184. Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci. 1997 Sep; 6(9):1806-24. Scheidig AJ, Hynes TR, Pelletier LA, Wells JA, Kossiakoff AA. PMID: 9300481; PMCID: PMC2143802.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    185. Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites. J Biol Chem. 1997 Aug 15; 272(33):20595-602. Pearce KH, Potts BJ, Presta LG, Bald LN, Fendly BM, Wells JA. PMID: 9252374.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    186. Minimized proteins. Curr Opin Struct Biol. 1997 Aug; 7(4):457-62. Cunningham BC, Wells JA. PMID: 9266165.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    187. Song development by grey catbirds Anim Behav. 1997 Aug; 54(2):457-64. Kroodsma DE, Houlihan PW, Fallon PA, Wells JA. PMID: 9268478.
      View in: PubMed   Mentions: 14     Fields:    
    188. Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7192-7. Muller YA, Li B, Christinger HW, Wells JA, Cunningham BC, de Vos AM. PMID: 9207067; PMCID: PMC23789.
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    189. Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library. J Mol Biol. 1997 Jul 04; 270(1):26-35. Atwell S, Ridgway JB, Wells JA, Carter P. PMID: 9231898.
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    190. Antibody humanization using monovalent phage display. J Biol Chem. 1997 Apr 18; 272(16):10678-84. Baca M, Presta LG, O'Connor SJ, Wells JA. PMID: 9099717.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    191. Synthesis of proteins by subtiligase. Methods Enzymol. 1997; 289:298-313. Braisted AC, Judice JK, Wells JA. PMID: 9353727.
      View in: PubMed   Mentions: 19     Fields:    
    192. Furilisin: a variant of subtilisin BPN' engineered for cleaving tribasic substrates. Biochemistry. 1996 Oct 22; 35(42):13579-85. Ballinger MD, Tom J, Wells JA. PMID: 8885837.
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    193. Long-acting growth hormones produced by conjugation with polyethylene glycol. J Biol Chem. 1996 Sep 06; 271(36):21969-77. Clark R, Olson K, Fuh G, Marian M, Mortensen D, Teshima G, Chang S, Chu H, Mukku V, Canova-Davis E, Somers T, Cronin M, Winkler M, Wells JA. PMID: 8703002.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    194. Structural and mutational analysis of affinity-inert contact residues at the growth hormone-receptor interface. Biochemistry. 1996 Aug 13; 35(32):10300-7. Pearce KH, Ultsch MH, Kelley RF, de Vos AM, Wells JA. PMID: 8756685.
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    195. Hormone mimicry. Science. 1996 Jul 26; 273(5274):449-50. Wells JA. PMID: 8677438.
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    196. Minimizing a binding domain from protein A. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):5688-92. Braisted AC, Wells JA. PMID: 8650153; PMCID: PMC39121.
      View in: PubMed   Mentions: 70     Fields:    Translation:Cells
    197. Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisation. Br J Ophthalmol. 1996 Apr; 80(4):363-6. Wells JA, Murthy R, Chibber R, Nunn A, Molinatti PA, Kohner EM, Gregor ZJ. PMID: 8703891; PMCID: PMC505466.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    198. Binding in the growth hormone receptor complex. Proc Natl Acad Sci U S A. 1996 Jan 09; 93(1):1-6. Wells JA. PMID: 8552582; PMCID: PMC40168.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    199. Hematopoietic receptor complexes. Annu Rev Biochem. 1996; 65:609-34. Wells JA, de Vos AM. PMID: 8811191.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    200. Surgical treatment of full-thickness macular holes using autologous serum. Eye (Lond). 1996; 10 ( Pt 5):593-9. Wells JA, Gregor ZJ. PMID: 8977788.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    201. Minimization of a polypeptide hormone. Science. 1995 Dec 08; 270(5242):1657-60. Li B, Tom JY, Oare D, Yen R, Fairbrother WJ, Wells JA, Cunningham BC. PMID: 7502074.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    202. Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group. N Engl J Med. 1995 Oct 26; 333(17):1093-8. Goddard AD, Covello R, Luoh SM, Clackson T, Attie KM, Gesundheit N, Rundle AC, Wells JA, Carlsson LM. PMID: 7565946.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    203. Designing subtilisin BPN' to cleave substrates containing dibasic residues. Biochemistry. 1995 Oct 17; 34(41):13312-9. Ballinger MD, Tom J, Wells JA. PMID: 7577915.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    204. Structural and functional epitopes in the growth hormone receptor complex. Biotechnology (N Y). 1995 Jul; 13(7):647-51. Wells JA. PMID: 9634801.
      View in: PubMed   Mentions: 3     Fields:    
    205. Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines. J Biol Chem. 1995 Jun 02; 270(22):13133-7. Fuh G, Wells JA. PMID: 7768908.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    206. The prevalence of homosexual behavior and attraction in the United States, the United Kingdom and France: results of national population-based samples. Arch Sex Behav. 1995 Jun; 24(3):235-48. Sell RL, Wells JA, Wypij D. PMID: 7611844.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    207. A hot spot of binding energy in a hormone-receptor interface. Science. 1995 Jan 20; 267(5196):383-6. Clackson T, Wells JA. PMID: 7529940.
      View in: PubMed   Mentions: 617     Fields:    Translation:HumansCells
    208. Subtiligase: a tool for semisynthesis of proteins. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12544-8. Chang TK, Jackson DY, Burnier JP, Wells JA. PMID: 7809074; PMCID: PMC45475.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    209. Readability of HIV/AIDS educational materials: the role of the medium of communication, target audience, and producer characteristics. Patient Educ Couns. 1994 Dec; 24(3):249-59. Wells JA. PMID: 7753718.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    210. Dissecting the energetics of an antibody-antigen interface by alanine shaving and molecular grafting. Protein Sci. 1994 Dec; 3(12):2351-7. Jin L, Wells JA. PMID: 7538848; PMCID: PMC2142782.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    211. Ocular findings associated with a 3 base pair deletion in the peripherin-RDS gene in autosomal dominant retinitis pigmentosa. Br J Ophthalmol. 1994 Nov; 78(11):831-6. Wroblewski JJ, Wells JA, Eckstein A, Fitzke FW, Jubb C, Keen TJ, Inglehearn CF, Bhattacharya SS, Arden GB, Jay MR, et al. PMID: 7848979; PMCID: PMC504967.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    212. A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues. Science. 1994 Oct 14; 266(5183):243-7. Jackson DY, Burnier J, Quan C, Stanley M, Tom J, Wells JA. PMID: 7939659.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    213. Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors. Ophthalmology. 1994 Sep; 101(9):1522-8. Holz FG, Wolfensberger TJ, Piguet B, Gross-Jendroska M, Wells JA, Minassian DC, Chisholm IH, Bird AC. PMID: 8090455.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    214. Engineering an interfacial zinc site to increase hormone-receptor affinity. Chem Biol. 1994 Sep; 1(1):25-30. Matthews DJ, Wells JA. PMID: 9383367.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    215. A survey of furin substrate specificity using substrate phage display. Protein Sci. 1994 Aug; 3(8):1197-205. Matthews DJ, Goodman LJ, Gorman CM, Wells JA. PMID: 7987214; PMCID: PMC2142928.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    216. Pouching principles and products. Ostomy Wound Manage. 1994 Jul-Aug; 40(6):50-8, 60-3. Wells JA, Doughty DB. PMID: 7880372.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    217. Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes. Endocrinology. 1994 Jun; 134(6):2397-403. Ilondo MM, Damholt AB, Cunningham BA, Wells JA, De Meyts P, Shymko RM. PMID: 8194466.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    218. Production of an atrial natriuretic peptide variant that is specific for type A receptor. EMBO J. 1994 Jun 01; 13(11):2508-15. Cunningham BC, Lowe DG, Li B, Bennett BD, Wells JA. PMID: 8013451; PMCID: PMC395124.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    219. In vitro selection of zinc fingers with altered DNA-binding specificity. Biochemistry. 1994 May 17; 33(19):5689-95. Jamieson AC, Kim SH, Wells JA. PMID: 8180194.
      View in: PubMed   Mentions: 53     Fields:    Translation:Cells
    220. A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4110-4. Wells JA, Fairbrother WJ, Otlewski J, Laskowski M, Burnier J. PMID: 8183880; PMCID: PMC43734.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    221. The stoichiometry of growth hormone-binding protein complexes in human plasma: comparison with cell surface receptors. J Clin Endocrinol Metab. 1994 May; 78(5):1113-8. Baumann G, Lowman HB, Mercado M, Wells JA. PMID: 8175967.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    222. Literacy of women attending family planning clinics in Virginia and reading levels of brochures on HIV prevention. Fam Plann Perspect. 1994 May-Jun; 26(3):113-5, 131. Wells JA, Ruscavage D, Parker B, McArthur L. PMID: 8070547.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    223. A second-generation study of 427 probands with congenital heart defects and their 837 children. J Am Coll Cardiol. 1994 May; 23(6):1459-67. Whittemore R, Wells JA, Castellsague X. PMID: 8176107.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    224. In vitro selection from protein and peptide libraries. Trends Biotechnol. 1994 May; 12(5):173-84. Clackson T, Wells JA. PMID: 7764900.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    225. Corneal opacities in spondyloepiphyseal dysplasia tarda. Cornea. 1994 May; 13(3):280-3. Wells JA, Ellerine NP, Fernhoff PM, Waring GO. PMID: 8033583.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    226. Structural and functional basis for hormone binding and receptor oligomerization. Curr Opin Cell Biol. 1994 Apr; 6(2):163-73. Wells JA. PMID: 8024806.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    227. Structure from function: screening structural models with functional data. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):113-7. Jin L, Cohen FE, Wells JA. PMID: 7506411; PMCID: PMC42896.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    228. Macular dystrophy associated with mutations at codon 172 in the human retinal degeneration slow gene. Ophthalmology. 1994 Jan; 101(1):12-22. Wroblewski JJ, Wells JA, Eckstein A, Fitzke F, Jubb C, Keen TJ, Inglehearn C, Bhattacharya S, Arden GB, Jay M, et al. PMID: 8302543.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    229. Affinity maturation of human growth hormone by monovalent phage display. J Mol Biol. 1993 Dec 05; 234(3):564-78. Lowman HB, Wells JA. PMID: 8254660.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    230. Comparison of a structural and a functional epitope. J Mol Biol. 1993 Dec 05; 234(3):554-63. Cunningham BC, Wells JA. PMID: 7504735.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansCells
    231. Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland. Endocrinology. 1993 Oct; 133(4):1602-8. Feldman M, Ruan W, Cunningham BC, Wells JA, Kleinberg DL. PMID: 8404600.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    232. Age-related Bruch's membrane change: a clinical study of the relative role of heredity and environment. Br J Ophthalmol. 1993 Jul; 77(7):400-3. Piguet B, Wells JA, Palmvang IB, Wormald R, Chisholm IH, Bird AC. PMID: 8343465; PMCID: PMC504547.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansPHPublic Health
    233. Substrate phage: selection of protease substrates by monovalent phage display. Science. 1993 May 21; 260(5111):1113-7. Matthews DJ, Wells JA. PMID: 8493554.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    234. Mechanism-based design of prolactin receptor antagonists. J Biol Chem. 1993 Mar 15; 268(8):5376-81. Fuh G, Colosi P, Wood WI, Wells JA. PMID: 8449901.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    235. Structure and function of human growth hormone: implications for the hematopoietins. Annu Rev Biophys Biomol Struct. 1993; 22:329-51. Wells JA, de Vos AM. PMID: 7688610.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    236. The molecular basis for growth hormone-receptor interactions. Recent Prog Horm Res. 1993; 48:253-75. Wells JA, Cunningham BC, Fuh G, Lowman HB, Bass SH, Mulkerrin MG, Ultsch M, deVos AM. PMID: 8441850.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    237. Health behavior changes in the United States, the United Kingdom, and France. J Gen Intern Med. 1992 Nov-Dec; 7(6):615-22. Retchin SM, Wells JA, Valleron AJ, Albrecht GL. PMID: 1453245.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    238. Immunodominant structures of human growth hormone identified by homolog-scanning mutagenesis. Mol Immunol. 1992 Sep; 29(9):1081-8. Weber JR, Nelson C, Cunningham BC, Wells JA, Fong S. PMID: 1495498.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    239. Incorporation of a stabilizing Ca(2+)-binding loop into subtilisin BPN'. Biochemistry. 1992 Sep 01; 31(34):7796-801. Braxton S, Wells JA. PMID: 1510966.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    240. High resolution functional analysis of antibody-antigen interactions. J Mol Biol. 1992 Aug 05; 226(3):851-65. Jin L, Fendly BM, Wells JA. PMID: 1380563.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    241. Rapid evolution of peptide and protein binding properties in vitro. Curr Opin Biotechnol. 1992 Aug; 3(4):355-62. Wells JA, Lowman HB. PMID: 1368436.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    242. Prevalence of obesity: a comparative survey in France, the United Kingdom and the United States. Int J Obes Relat Metab Disord. 1992 Aug; 16(8):565-72. Laurier D, Guiguet M, Chau NP, Wells JA, Valleron AJ. PMID: 1326486.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    243. Effect of aging and exercise on GLUT-4 glucose transporters in muscle. Am J Physiol. 1992 Aug; 263(2 Pt 1):E362-7. Kern M, Dolan PL, Mazzeo RS, Wells JA, Dohm GL. PMID: 1514619.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    244. Rational design of potent antagonists to the human growth hormone receptor. Science. 1992 Jun 19; 256(5064):1677-80. Fuh G, Cunningham BC, Fukunaga R, Nagata S, Goeddel DV, Wells JA. PMID: 1535167.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    245. Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor. J Clin Invest. 1992 Feb; 89(2):451-7. Fu YK, Arkins S, Fuh G, Cunningham BC, Wells JA, Fong S, Cronin MJ, Dantzer R, Kelley KW. PMID: 1310696; PMCID: PMC442872.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    246. [Prevalence of obesity in France]. Rev Epidemiol Sante Publique. 1992; 40(5):365-7. Laurier D, Guiguet M, Chau NP, Wells JA, Valleron AJ. PMID: 1480813.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    247. Keratoconus associated with posterior polymorphous dystrophy. Am J Ophthalmol. 1991 Dec 15; 112(6):729-31. Bechara SJ, Grossniklaus HE, Waring GO, Wells JA. PMID: 1957913.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    248. Selecting high-affinity binding proteins by monovalent phage display. Biochemistry. 1991 Nov 12; 30(45):10832-8. Lowman HB, Bass SH, Simpson N, Wells JA. PMID: 1932005.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    249. Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science. 1991 Nov 08; 254(5033):821-5. Cunningham BC, Ultsch M, De Vos AM, Mulkerrin MG, Clauser KR, Wells JA. PMID: 1948064.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansCells
    250. Dimerization of human growth hormone by zinc. Science. 1991 Aug 02; 253(5019):545-8. Cunningham BC, Mulkerrin MG, Wells JA. PMID: 1907025.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    251. French intravenous drug users: knowledge and sexual behavior change. Eur J Epidemiol. 1991 Jul; 7(4):423-6. Guiguet M, Cohen M, Flahault A, Wells JA, Valleron AJ. PMID: 1915793.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    252. The importance of a distal hydrogen bonding group in stabilizing the transition state in subtilisin BPN'. J Biol Chem. 1991 Jun 25; 266(18):11797-800. Braxton S, Wells JA. PMID: 1904870.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    253. Probing the mechanism and improving the rate of substrate-assisted catalysis in subtilisin BPN'. Biochemistry. 1991 Jun 25; 30(25):6142-8. Carter P, Abrahmsén L, Wells JA. PMID: 2059622.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    254. Mutational analysis and protein engineering of receptor-binding determinants in human placental lactogen. J Biol Chem. 1991 Jun 15; 266(17):10982-8. Lowman HB, Cunningham BC, Wells JA. PMID: 2040614.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    255. A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4498-502. Bass SH, Mulkerrin MG, Wells JA. PMID: 2034689; PMCID: PMC51688.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    256. Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution. Biochemistry. 1991 Apr 30; 30(17):4151-9. Abrahmsén L, Tom J, Burnier J, Butcher KA, Kossiakoff A, Wells JA. PMID: 2021606.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    257. Rational design of receptor-specific variants of human growth hormone. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):3407-11. Cunningham BC, Wells JA. PMID: 2014261; PMCID: PMC51456.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    258. Systematic mutational analyses of protein-protein interfaces. Methods Enzymol. 1991; 202:390-411. Wells JA. PMID: 1723781.
      View in: PubMed   Mentions: 103     Fields:    Translation:Cells
    259. Zinc mediation of the binding of human growth hormone to the human prolactin receptor. Science. 1990 Dec 21; 250(4988):1709-12. Cunningham BC, Bass S, Fuh G, Wells JA. PMID: 2270485.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    260. Additivity of mutational effects in proteins. Biochemistry. 1990 Sep 18; 29(37):8509-17. Wells JA. PMID: 2271534.
      View in: PubMed   Mentions: 189     Fields:    Translation:Cells
    261. Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level. Biochem J. 1990 Sep 01; 270(2):397-400. Kern M, Wells JA, Stephens JM, Elton CW, Friedman JE, Tapscott EB, Pekala PH, Dohm GL. PMID: 2205203; PMCID: PMC1131735.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    262. Increased glucose transporter (GLUT4) protein expression in hyperthyroidism. Biochem Biophys Res Commun. 1990 Aug 31; 171(1):182-8. Casla A, Rovira A, Wells JA, Dohm GL. PMID: 2203344.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    263. The role of lysine-234 in beta-lactamase catalysis probed by site-directed mutagenesis. Biochemistry. 1990 Jun 19; 29(24):5797-806. Ellerby LM, Escobar WA, Fink AL, Mitchinson C, Wells JA. PMID: 1974463.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    264. Engineering human prolactin to bind to the human growth hormone receptor. Science. 1990 Mar 23; 247(4949 Pt 1):1461-5. Cunningham BC, Henner DJ, Wells JA. PMID: 2321008.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    265. The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain. J Biol Chem. 1990 Feb 25; 265(6):3111-5. Fuh G, Mulkerrin MG, Bass S, McFarland N, Brochier M, Bourell JH, Light DR, Wells JA. PMID: 2406245.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    266. The effect of fasting on the activation in vivo of the insulin receptor kinase. Biochem J. 1990 Feb 01; 265(3):887-90. Contreras I, Dohm GL, Abdallah S, Wells JA, Mooney N, Rovira A, Caro JF. PMID: 2407238; PMCID: PMC1133714.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    267. Part I: The NGRI Registry: initial analyses of data collected on Connecticut insanity acquittees. Bull Am Acad Psychiatry Law. 1990; 18(2):115-28. Zonana HV, Wells JA, Getz MA, Buchanan J. PMID: 2372573.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    268. Part II: Sex differences in persons found not guilty by reason of insanity: analysis of data from the Connecticut NGRI Registry. Bull Am Acad Psychiatry Law. 1990; 18(2):129-42. Zonana HV, Bartel RL, Wells JA, Buchanan JA, Getz MA. PMID: 2372574.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    269. Respiratory rate during acute asthma. Chest. 1990 Jan; 97(1):58-62. Kesten S, Maleki-Yazdi R, Sanders BR, Wells JA, McKillop SL, Chapman KR, Rebuck AS. PMID: 2403901.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    270. Functional interaction among catalytic residues in subtilisin BPN'. Proteins. 1990; 7(4):335-42. Carter P, Wells JA. PMID: 2199971.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    271. Identification and design of binding determinants in proteins. Biochem Soc Symp. 1990; 57:143-5. Wells JA, Cunningham BC. PMID: 2099738.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    272. Hormone phage: an enrichment method for variant proteins with altered binding properties. Proteins. 1990; 8(4):309-14. Bass S, Greene R, Wells JA. PMID: 1708882.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    273. High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science. 1989 Jun 02; 244(4908):1081-5. Cunningham BC, Wells JA. PMID: 2471267.
      View in: PubMed   Mentions: 416     Fields:    Translation:HumansCells
    274. Protein engineering of disulfide bonds in subtilisin BPN'. Biochemistry. 1989 May 30; 28(11):4807-15. Mitchinson C, Wells JA. PMID: 2504281.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    275. Changes in glucose transporters in muscle in response to exercise. Am J Physiol. 1989 May; 256(5 Pt 1):E580-7. Fushiki T, Wells JA, Tapscott EB, Dohm GL. PMID: 2655468.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    276. Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis. Science. 1989 Mar 10; 243(4896):1330-6. Cunningham BC, Jhurani P, Ng P, Wells JA. PMID: 2466339.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    277. Engineering subtilisin BPN' for site-specific proteolysis. Proteins. 1989; 6(3):240-8. Carter P, Nilsson B, Burnier JP, Burdick D, Wells JA. PMID: 2516317.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    278. The influence of source of insurance coverage on the health care utilization patterns of the elderly. J Health Hum Resour Adm. 1989; 11(3):285-311. Dunlop BD, Wells JA, Wilensky GR. PMID: 10303344.
      View in: PubMed   Mentions: 1  Translation:Humans
    279. Subtilisin--an enzyme designed to be engineered. Trends Biochem Sci. 1988 Aug; 13(8):291-7. Wells JA, Estell DA. PMID: 3154281.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    280. Dissecting the catalytic triad of a serine protease. Nature. 1988 Apr 07; 332(6164):564-8. Carter P, Wells JA. PMID: 3282170.
      View in: PubMed   Mentions: 133     Fields:    Translation:Cells
    281. GrantWatch. Foundation funding for AIDS education. Health Aff (Millwood). 1988; 7(5):146-58. Wells JA, Zuercher A, Clinton J. PMID: 3229713.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    282. Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering. Proc Natl Acad Sci U S A. 1987 Aug; 84(15):5167-71. Wells JA, Cunningham BC, Graycar TP, Estell DA. PMID: 3299378; PMCID: PMC298815.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    283. Improvement in the alkaline stability of subtilisin using an efficient random mutagenesis and screening procedure. Protein Eng. 1987 Aug-Sep; 1(4):319-25. Cunningham BC, Wells JA. PMID: 3334089.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    284. Engineering enzyme specificity by "substrate-assisted catalysis". Science. 1987 Jul 24; 237(4813):394-9. Carter P, Wells JA. PMID: 3299704.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    285. Patient age distribution in thalassemia major: changes from 1973 to 1985. Pediatrics. 1987 Jul; 80(1):53-7. Pearson HA, Guiliotis DK, Rink L, Wells JA. PMID: 3601518.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    286. Designing substrate specificity by protein engineering of electrostatic interactions. Proc Natl Acad Sci U S A. 1987 Mar; 84(5):1219-23. Wells JA, Powers DB, Bott RR, Graycar TP, Estell DA. PMID: 3547407; PMCID: PMC304398.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    287. Foundation funding for AIDS programs. Health Aff (Millwood). 1987; 6(3):113-23. Wells JA. PMID: 3679069.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    288. On the evolution of specificity and catalysis in subtilisin. Cold Spring Harb Symp Quant Biol. 1987; 52:647-52. Wells JA, Cunningham BC, Graycar TP, Estell DA, Carter P. PMID: 3331349.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    289. Thoracoabdominal motion in response to treadmill and cycle exercise. Am Rev Respir Dis. 1986 Dec; 134(6):1125-8. Wells JA, Smyth RJ, Rebuck AS. PMID: 3098144.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    290. Probing steric and hydrophobic effects on enzyme-substrate interactions by protein engineering. Science. 1986 Aug 08; 233(4764):659-63. Estell DA, Graycar TP, Miller JV, Powers DB, Wells JA, Burnier JP, Ng PG. PMID: 17835820.
      View in: PubMed   Mentions: 32     Fields:    
    291. In vivo formation and stability of engineered disulfide bonds in subtilisin. J Biol Chem. 1986 May 15; 261(14):6564-70. Wells JA, Powers DB. PMID: 3516996.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    292. Secretion and autoproteolytic maturation of subtilisin. Proc Natl Acad Sci U S A. 1986 May; 83(10):3096-100. Power SD, Adams RM, Wells JA. PMID: 3517850; PMCID: PMC323459.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    293. 2-[(4-Azido-2-nitrophenyl)amino]ethyl triphosphate, a novel chromophoric and photoaffinity analogue of ATP. Synthesis, characterization, and interaction with myosin subfragment 1. Biochemistry. 1985 Sep 10; 24(19):5226-35. Nakamaye KL, Wells JA, Bridenbaugh RL, Okamoto Y, Yount RG. PMID: 4074691.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    294. Engineering an enzyme by site-directed mutagenesis to be resistant to chemical oxidation. J Biol Chem. 1985 Jun 10; 260(11):6518-21. Estell DA, Graycar TP, Wells JA. PMID: 3922976.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    295. Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites. Gene. 1985; 34(2-3):315-23. Wells JA, Vasser M, Powers DB. PMID: 3891521.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    296. Characterization of the properties of ethenoadenosine nucleotides bound or trapped at the active site of myosin subfragment 1. Biochemistry. 1984 Aug 14; 23(17):3994-4002. Perkins WJ, Wells JA, Yount RG. PMID: 6237680.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    297. An improved method for purifying 2',5'-oligoadenylate synthetases. J Biol Chem. 1984 Jan 25; 259(2):1363-70. Wells JA, Swyryd EA, Stark GR. PMID: 6693390.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    298. Awareness by consumers and the adoption of a new service: an HMO example. J Health Care Mark. 1984; 4(1):17-24. Griffith MJ, Wells JA. PMID: 10266249.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    299. Cloning, sequencing, and secretion of Bacillus amyloliquefaciens subtilisin in Bacillus subtilis. Nucleic Acids Res. 1983 Nov 25; 11(22):7911-25. Wells JA, Ferrari E, Henner DJ, Estell DA, Chen EY. PMID: 6316278; PMCID: PMC326549.
      View in: PubMed   Mentions: 98     Fields:    Translation:Cells
    300. Musculoskeletal disorders among letter carriers. A comparison of weight carrying, walking & sedentary occupations. J Occup Med. 1983 Nov; 25(11):814-20. Wells JA, Zipp JF, Schuette PT, McEleney J. PMID: 6644392.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    301. Trapping of transition metal-nucleotide complexes in myosin subfragment 1 by cross-linking thiols; divalent transition metal probes of the active site. Biochemistry. 1983 Jan 18; 22(2):490-6. Dalbey RE, Wells JA, Yount RG. PMID: 6824640.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    302. Physiogenic bias as invalidity in psychiatric symptom scales. J Health Soc Behav. 1982 Sep; 23(3):235-52. Wells JA, Strickland DE. PMID: 7175160.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    303. Chemical modification of myosin by active-site trapping of metal-nucleotides with thiol crosslinking reagents. Methods Enzymol. 1982; 85 Pt B:93-116. Wells JA, Yount RG. PMID: 7121292.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    304. Cross-linking of myosin subfragment 1. Nucleotide-enhanced modification by a variety of bifunctional reagents. J Biol Chem. 1980 Dec 10; 255(23):11135-40. Wells JA, Knoeber C, Sheldon MC, Werber MM, Yount RG. PMID: 7440533.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    305. Mechanism of inactivation of myosin subfragment 1 by Co(III)phenATP. A reinvestigation. J Biol Chem. 1980 Aug 25; 255(16):7552-5. Wells JA, Werber MM, Yount RG. PMID: 6447149.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    306. Reaction of 5,5'-dithiobis(2-nitrobenzoic acid) with myosin subfragment one: evidence for formation of a single protein disulfide with trapping of metal nucleotide at the active site. Biochemistry. 1980 Apr 15; 19(8):1711-7. Wells JA, Yount RG. PMID: 6445748.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    307. Magnesium nucleotide is stoichiometrically trapped at the active site of myosin and its active proteolytic fragments by thiol cross-linking reagents. J Biol Chem. 1980 Feb 25; 255(4):1598-602. Wells JA, Sheldon M, Yount RG. PMID: 6444414.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    308. "Reaction of 5,5'-dithiobis (2-nitrobenzoic acid) with myosin subfragment one: Evidence for formation of a single protein disulfide with trapping of metal nucleotide at the active site". Biochemistry. 1980; 19:1711-1717. Wells, J.A. and Yount, R.G.
    309. "Magnesium nucleotide is stoichiometrically trapped at the active site of myosin and its proteolytic subfragments by thiol cross-linking reagents". J. Biol. Chem. 1980; 255:1598-1602. Wells, J.A., Sheldon, M., and Yount, R.G.
    310. Inactivation of myosin subfragment one by cobalt(II)/cobalt(III) phenanthroline complexes. I. Incorporation of Co(III) by in situ oxidation of Co(II). Biochemistry. 1979 Oct 30; 18(22):4793-9. Wells JA, Werber MM, Legg JI, Yount RG. PMID: 41570.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    311. Inactivation of myosin subfragment one by cobalt(II)/cobalt(III) phenanthroline complexes. 2. Cobalt chelation of two critical SH groups. Biochemistry. 1979 Oct 30; 18(22):4800-5. Wells JA, Werber MM, Yount RG. PMID: 159719.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    312. Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin subfragment 1. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):4966-70. Wells JA, Yount RG. PMID: 159451; PMCID: PMC413059.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    313. Occupational stress and health among factory workers. J Health Soc Behav. 1979 Jun; 20(2):139-60. House JS, McMichael AJ, Wells JA, Kaplan BH, Landerman LR. PMID: 479526.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    314. "Inactivation of myosin subfragment one by cobalt (II)/cobalt (III) phenanthroline complexes. 1. Incorporation of Co(III) by in situ oxidation of Co(II)". Biochemistry. 1979; 18:4793-4799. . Wells, J.A., Werber, M.M. and Yount, R.G.
    315. "Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin sub-fragment 1". Proc. Natl. Acad. Sci. USA. 1979; 76:4966-4970. Wells, J.A. and Yount, R.G.
    316. "Inactivation of myosin subfragment one by cobalt (II)/cobalt (III) phenanthroline complexes. 2. Cobalt chelation of two critical SH groups". Biochemistry. 1979; 18:4800-4805. Wells, J.A., Werber, M.M., Legg, J.I., and Yount, R.G.
    317. Do we need a burn severity grading system. J Trauma. 1977 Mar; 17(3):252-5. Fisher JC, Wells JA, Fulwider BT, Edgerton MT. PMID: 850285.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    318. Issues in specialty certification. ANA Publ. 1975; (PMH-2):6-14. Wells JA. PMID: 1045880.
      View in: PubMed   Mentions:    Fields:    
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