Jim Wells, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1700 4th St
San Francisco CA 94158
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    Other Positions
    Title(s)Chair, Pharmaceutical Chemistry

    Collapse Biography 
    Collapse Awards and Honors
    1979  - 1981Damon M. Runyon-Walter Winchell Postdoctoral Fellowship
    American Cancer Society1990Pfizer Award for achievements in enzyme chemistry
    Perdue University1991Joseph Foster Award Lecturer
    Washington State University1992Alumni Achievement Award
    Temple University1994Distinguished Award Lecture
    Rockefeller University1995Stein Memorial Award Lecture
    SUNY Stony Brook1997Begelsteil Award Lecture
    1997Frontiers in Biological Sciences Lecture, Case Western Reserve
    Washington State University1997Distinguished Alumni Award
    Protein Society1998Christian B. Anfinsin Awar
    American Peptide Society1998Vincent du Vignead Award
    NAS1999Elected Member to the National Academy of Sciences
    Protein Society2003Hans Neurath Award
    Harvard Medical School2005Otto Krayer Lectureship
    Boston College2005Boston College Distinguished Lectureship in Chemistry
    Stanford University2005Cutting Award Lecture
    2005Braisted Award Lecture
    American Cancer Society, Biotech2006Perlman Lecture Award of the ACS Biotechnology Division
    Nature Biotechnology2006Shortlisted Nominee, Nature Biotechnology’s Who’s Who in Biotech, most significant contribution to b
    CABM, Rutgers University2006Paul Janssen Prize in Adv. Biotech and Medicine
    Yale University2007Fred Richards Distinguished Lecture
    Rockefeller University2008Jane Darnell Distinguished Lecture
    Johns Hopkins University2009Kossiakoff Lecture in Biophysics
    University of Chicago2009Herman S. Bloch Award, “for scientific excellence in industry”
    Thomas Jefferson University2009Weinhouse Lecture in Biochemistry
    ASBMB2010Merck Award
    American Cancer Society2011Smissman Award in Medicinal Chemistry
    University of Illinois2011Ada Doisy Lectures
    Washington University, St Louis2011Carl and Gerty Cori Lecture
    University of Wisconsin, Madison2011Green Lecture
    St Luke's, Boise ID2011Burkholder Award Lecture
    Vanderbilt University, TN2012Lubomir S. Hnilica Endowed Lecture
    University of Washington, Seattle2012Gordon Lecture
    Gladstone, San Francisco2012Keynote at Gladstone Scientific Retreat
    UCSC Department of Chemistry and Biochemistry2013Keynote Speaker
    ICSB and Kyoto University2013Keynote Speaker at ICSB Meeting
    Tsinghua University2013Keynote Speaker, Symposium of Frontier Sciences on New Drug Discovery
    American Academy of Arts and Sciences2015Elected Member of Academy

    Collapse Overview 
    Collapse Overview
    James "Jim" Wells focuses on understanding and modulating signaling processes in human cells through protein and small molecule design. His lab seeks activators as well as inhibitors of signaling molecules, including proteases and kinases, and uses them to study the consequences of triggering specific nodes of signaling circuits. He is especially interested in the inter-protein circuitry of pathways involved in cell death and inflammation, and the intra-protein allosteric circuitry that governs how distant functional sites in one protein communicate.

    Collapse Research 
    Collapse Research Activities and Funding
    Antibody Research Technology Center
    NIH/NCI P41CA196276Sep 24, 2014 - Aug 31, 2019
    Role: Co-Investigator
    Affinity-directed tagging of protein binding partners in signaling
    NIH R01CA191018Jun 16, 2014 - May 31, 2019
    Role: Principal Investigator
    Generation of recombinant thiopeptides to target antimicrobial-resistant bacteria
    NIH R21AI111662Mar 1, 2014 - Feb 29, 2016
    Role: Principal Investigator
    Automated System for High-Throughput In Vitro Selection of Recombinant Antibodies
    NIH S10OD012037May 15, 2012 - May 14, 2014
    Role: Principal Investigator
    Regulating Proteolysis to Dissect Apoptosis
    NIH R01GM097316Sep 20, 2011 - Jun 30, 2015
    Role: Principal Investigator
    Approaches to discover and quantify apoptotic biomarkers for cancer treatment
    NIH R01CA154802Feb 1, 2011 - Jan 31, 2015
    Role: Principal Investigator
    Start-up Funds for Junior Faculty in Chemical Biology Group at UCSF
    NIH P30GM092427Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    High-throughput SPR Instrument for Small Molecule Discovery
    NIH S10RR025448Jan 1, 2009 - Dec 31, 2009
    Role: Principal Investigator
    Direct Chemical Activators of Caspases
    NIH R01CA136779Dec 5, 2008 - Nov 30, 2014
    Role: Principal Investigator
    Global Analysis of Proteolysis in Apoptosis
    NIH R01GM081051Apr 1, 2007 - Jul 31, 2016
    Role: Principal Investigator
    Site-specific Allosteric Inhibitors for Inflammatory Caspases
    NIH R01AI070292Mar 15, 2007 - Feb 28, 2013
    Role: Principal Investigator
    Activators of Procaspase-7
    NIH R21NS057022Jul 20, 2006 - Jul 19, 2007
    Role: Principal Investigator
    New Advances in Drug Discovery
    NIH R13CA098965Jan 13, 2003 - Dec 31, 2003
    Role: Principal Investigator
    HIV Integrase Drug Discovery Using Tethering Technology
    NIH R43AI052630Jul 1, 2002 - Jun 30, 2004
    Role: Principal Investigator
    NIH R43CA083440Jul 16, 1999 - Jun 30, 2000
    Role: Principal Investigator
    NIH R44CA085141Jul 1, 1999 - Feb 28, 2003
    Role: Principal Investigator
    NIH R43CA085141Jul 1, 1999 - Jun 30, 2001
    Role: Principal Investigator
    NIH R43CA062794Sep 30, 1996 - Mar 29, 1997
    Role: Principal Investigator
    NIH R43HD030126Feb 1, 1993 - Jul 31, 1993
    Role: Principal Investigator
    NIH R01HD026265Sep 1, 1989 - Oct 31, 1990
    Role: Principal Investigator
    NIH R01MH045661Jul 1, 1989 - Jun 30, 1990
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection. medRxiv. 2020 Aug 21. Elledge SK, Zhou XX, Byrnes JR, Martinko AJ, Lui I, Pance K, Lim SA, Glasgow JE, Glasgow AA, Turcios K, Iyer N, Torres L, Peluso MJ, Henrich TJ, Wang TT, Tato CM, Leung KK, Greenhouse B, Wells JA. PMID: 32839788.
      View in: PubMed   Mentions:
    2. Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike. bioRxiv. 2020 Aug 10. Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, Zhou XX, Leung KK, Wells JA. PMID: 32817948.
      View in: PubMed   Mentions:
    3. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. bioRxiv. 2020 Aug 01. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 32766586.
      View in: PubMed   Mentions:
    4. Redox priming promotes Aurora A activation during mitosis. Sci Signal. 2020 Jul 21; 13(641). Lim DC, Joukov V, Rettenmaier TJ, Kumagai A, Dunphy WG, Wells JA, Yaffe MB. PMID: 32694171.
      View in: PubMed   Mentions:    Fields:    
    5. A SARS-CoV-2 serological assay to determine the presence of blocking antibodies that compete for human ACE2 binding. medRxiv. 2020 May 29. Byrnes JR, Zhou XX, Lui I, Elledge SK, Glasgow JE, Lim SA, Loudermilk R, Chiu CY, Wilson MR, Leung KK, Wells JA. PMID: 32511506.
      View in: PubMed   Mentions:
    6. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chem Biol. 2020 Jun 18; 27(6):647-656.e6. Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, Walensky LD. PMID: 32413285.
      View in: PubMed   Mentions:    Fields:    
    7. Theranostic Targeting of CUB Domain Containing Protein 1 (CDCP1) in Pancreatic Cancer. Clin Cancer Res. 2020 Jul 15; 26(14):3608-3615. Moroz A, Wang YH, Sharib JM, Wei J, Zhao N, Huang Y, Chen Z, Martinko AJ, Zhuo J, Lim SA, Zhang LH, Seo Y, Carlin S, Leung KK, Collisson EA, Kirkwood KS, Wells JA, Evans MJ. PMID: 32341034.
      View in: PubMed   Mentions:    Fields:    
    8. National Cancer Institute Think-Tank Meeting Report on Proteomic Cartography and Biomarkers at the Single-Cell Level: Interrogation of Premalignant Lesions. J Proteome Res. 2020 May 01; 19(5):1900-1912. Kagan J, Moritz RL, Mazurchuk R, Lee JH, Kharchenko PV, Rozenblatt-Rosen O, Ruppin E, Edfors F, Ginty F, Goltsev Y, Wells JA, LaCava J, Riesterer JL, Germain RN, Shi T, Chee MS, Budnik BA, Yates JR, Chait BT, Moffitt JR, Smith RD, Srivastava S. PMID: 32163288.
      View in: PubMed   Mentions:    Fields:    
    9. Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7764-7775. Leung KK, Wilson GM, Kirkemo LL, Riley NM, Coon JJ, Wells JA. PMID: 32205440.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):5733-5740. Elledge SK, Tran HL, Christian AH, Steri V, Hann B, Toste FD, Chang CJ, Wells JA. PMID: 32123103.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. N-Terminal Modification of Proteins with Subtiligase Specificity Variants. Curr Protoc Chem Biol. 2020 Mar; 12(1):e79. Weeks AM, Wells JA. PMID: 32074409.
      View in: PubMed   Mentions:    Fields:    
    12. Profiling the Surfaceome Identifies Therapeutic Targets for Cells with Hyperactive mTORC1 Signaling. Mol Cell Proteomics. 2020 02; 19(2):294-307. Wei J, Leung K, Truillet C, Ruggero D, Wells JA, Evans MJ. PMID: 31792071.
      View in: PubMed   Mentions: 1     Fields:    
    13. Subtiligase-Catalyzed Peptide Ligation. Chem Rev. 2020 Mar 25; 120(6):3127-3160. Weeks AM, Wells JA. PMID: 31663725.
      View in: PubMed   Mentions:    Fields:    
    14. Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases. J Med Chem. 2019 07 25; 62(14):6512-6524. Yueh C, Rettenmaier J, Xia B, Hall DR, Alekseenko A, Porter KA, Barkovich K, Keseru G, Whitty A, Wells JA, Vajda S, Kozakov D. PMID: 31274316.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Neuronally Enriched RUFY3 Is Required for Caspase-Mediated Axon Degeneration. Neuron. 2019 08 07; 103(3):412-422.e4. Hertz NT, Adams EL, Weber RA, Shen RJ, O'Rourke MK, Simon DJ, Zebroski H, Olsen O, Morgan CW, Mileur TR, Hitchcock AM, Sinnott Armstrong NA, Wainberg M, Bassik MC, Molina H, Wells JA, Tessier-Lavigne M. PMID: 31221560.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome. Proc Natl Acad Sci U S A. 2019 01 08; 116(2):695-700. Leung KK, Nguyen A, Shi T, Tang L, Ni X, Escoubet L, MacBeth KJ, DiMartino J, Wells JA. PMID: 30584089.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Engineering Improved Antiphosphotyrosine Antibodies Based on an Immunoconvergent Binding Motif. J Am Chem Soc. 2018 12 05; 140(48):16615-16624. Mou Y, Zhou XX, Leung K, Martinko AJ, Yu JY, Chen W, Wells JA. PMID: 30398859.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators. Proc Natl Acad Sci U S A. 2018 09 04; 115(36):8960-8965. Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL, Fierke CA, Mapp AK. PMID: 30127017.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins. ACS Chem Biol. 2018 09 21; 13(9):2398-2405. Hill ME, Kumar A, Wells JA, Hobman TC, Julien O, Hardy JA. PMID: 30080377.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    20. An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife. 2018 06 07; 7. Keedy DA, Hill ZB, Biel JT, Kang E, Rettenmaier TJ, Brandão-Neto J, Pearce NM, von Delft F, Wells JA, Fraser JS. PMID: 29877794.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    21. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 05 07; 15(5):2054-2059. Spangler B, Kline T, Hanson J, Li X, Zhou S, Wells JA, Sato AK, Renslo AR. PMID: 29569925.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. Proc Natl Acad Sci U S A. 2018 03 13; 115(11):2836-2841. Pollock SB, Hu A, Mou Y, Martinko AJ, Julien O, Hornsby M, Ploder L, Adams JJ, Geng H, Müschen M, Sidhu SS, Moffat J, Wells JA. PMID: 29476010.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018 03; 25(3):486-541. Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G. PMID: 29362479.
      View in: PubMed   Mentions: 260     Fields:    Translation:HumansAnimalsCells
    24. Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins. Elife. 2018 01 23; 7. Martinko AJ, Truillet C, Julien O, Diaz JE, Horlbeck MA, Whiteley G, Blonder J, Weissman JS, Bandyopadhyay S, Evans MJ, Wells JA. PMID: 29359686.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    25. Human antibody-based chemically induced dimerizers for cell therapeutic applications. Nat Chem Biol. 2018 02; 14(2):112-117. Hill ZB, Martinko AJ, Nguyen DP, Wells JA. PMID: 29200207.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    26. Engineering peptide ligase specificity by proteomic identification of ligation sites. Nat Chem Biol. 2018 Jan; 14(1):50-57. Weeks AM, Wells JA. PMID: 29155430.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    27. Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades. Mol Cancer Res. 2018 01; 16(1):58-68. Srinivasan SR, Cesa LC, Li X, Julien O, Zhuang M, Shao H, Chung J, Maillard I, Wells JA, Duckett CS, Gestwicki JE. PMID: 28970360.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    28. A Split-Abl Kinase for Direct Activation in Cells. Cell Chem Biol. 2017 Oct 19; 24(10):1250-1258.e4. Diaz JE, Morgan CW, Minogue CE, Hebert AS, Coon JJ, Wells JA. PMID: 28919041.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    29. Engineering a light-activated caspase-3 for precise ablation of neurons in vivo. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):E8174-E8183. Smart AD, Pache RA, Thomsen ND, Kortemme T, Davis GW, Wells JA. PMID: 28893998.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    30. Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics. Cell Syst. 2017 06 28; 4(6):636-644.e9. Liu TY, Huang HH, Wheeler D, Xu Y, Wells JA, Song YS, Wiita AP. PMID: 28578850.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    31. Caspases and their substrates. Cell Death Differ. 2017 08; 24(8):1380-1389. Julien O, Wells JA. PMID: 28498362.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    32. Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product. J Am Chem Soc. 2017 02 22; 139(7):2541-2544. Tran HL, Lexa KW, Julien O, Young TS, Walsh CT, Jacobson MP, Wells JA. PMID: 28170244.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    33. Redox-based reagents for chemoselective methionine bioconjugation. Science. 2017 02 10; 355(6325):597-602. Lin S, Yang X, Jia S, Weeks AM, Hornsby M, Lee PS, Nichiporuk RV, Iavarone AT, Wells JA, Toste FD, Chang CJ. PMID: 28183972.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    34. Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast. Mol Cell Proteomics. 2017 04; 16(4):512-523. Calvo SE, Julien O, Clauser KR, Shen H, Kamer KJ, Wells JA, Mootha VK. PMID: 28122942.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    35. Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface. Oncotarget. 2016 Dec 27; 7(52):86948-86971. Ye X, Chan KC, Waters AM, Bess M, Harned A, Wei BR, Loncarek J, Luke BT, Orsburn BC, Hollinger BD, Stephens RM, Bagni R, Martinko A, Wells JA, Nissley DV, McCormick F, Whiteley G, Blonder J. PMID: 27894102.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    36. A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models. J Med Chem. 2016 12 22; 59(24):11161-11170. Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR. PMID: 27936709.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    37. Direct Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase. J Am Chem Soc. 2016 10 12; 138(40):13123-13126. Hill ZB, Pollock SB, Zhuang M, Wells JA. PMID: 27626304.
      View in: PubMed   Mentions: 4     Fields:    
    38. Enzyme-catalyzed expressed protein ligation. Nat Methods. 2016 Nov; 13(11):925-927. Henager SH, Chu N, Chen Z, Bolduc D, Dempsey DR, Hwang Y, Wells J, Cole PA. PMID: 27669326.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    39. Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein a-synuclein. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9587-92. Wang W, Nguyen LT, Burlak C, Chegini F, Guo F, Chataway T, Ju S, Fisher OS, Miller DW, Datta D, Wu F, Wu CX, Landeru A, Wells JA, Cookson MR, Boxer MB, Thomas CJ, Gai WP, Ringe D, Petsko GA, Hoang QQ. PMID: 27482083.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    40. Stem Cells and Regeneration in the Digestive System: Keystone Meeting. Gastroenterology. 2016 09; 151(3):e6-9. Soffers JH, Hansen D, Sinagoga KL, Li B, Martin MG, Wells J, Grompe M, Li L. PMID: 27480172.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    41. A reactivity-based probe of the intracellular labile ferrous iron pool. Nat Chem Biol. 2016 09; 12(9):680-5. Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, Renslo AR. PMID: 27376690.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    42. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity. Nat Commun. 2016 07 01; 7:12009. Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA. PMID: 27363581.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    43. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. ACS Chem Biol. 2016 06 17; 11(6):1603-12. Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA. PMID: 27032039.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    44. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proc Natl Acad Sci U S A. 2016 Apr 05; 113(14):E2001-10. Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. PMID: 27006500.
      View in: PubMed   Mentions: 17     Fields:    
    45. Initial Results from the Survey of Organizational Research Climates (SOuRCe) in the U.S. Department of Veterans Affairs Healthcare System. PLoS One. 2016; 11(3):e0151571. Martinson BC, Nelson D, Hagel-Campbell E, Mohr D, Charns MP, Bangerter A, Thrush CR, Ghilardi JR, Bloomfield H, Owen R, Wells JA. PMID: 26967736.
      View in: PubMed   Mentions: 4     Fields:    
    46. CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites. J Mol Biol. 2016 Feb 22; 428(4):709-719. Cimermancic P, Weinkam P, Rettenmaier TJ, Bichmann L, Keedy DA, Woldeyes RA, Schneidman-Duhovny D, Demerdash ON, Mitchell JC, Wells JA, Fraser JS, Sali A. PMID: 26854760.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    47. Small-Molecule Allosteric Modulators of the Protein Kinase PDK1 from Structure-Based Docking. J Med Chem. 2015 Oct 22; 58(20):8285-8291. Rettenmaier TJ, Fan H, Karpiak J, Doak A, Sali A, Shoichet BK, Wells JA. PMID: 26443011.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    48. A High Through-put Platform for Recombinant Antibodies to Folded Proteins. Mol Cell Proteomics. 2015 Oct; 14(10):2833-47. Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, Hoey RJ, Lai D, Griffin C, Li Z, Vizeacoumar FJ, Dong D, Campbell E, Anderson S, Zhong N, Gräslund S, Koide S, Moffat J, Sidhu S, Kossiakoff A, Wells J. PMID: 26290498.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    49. Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8344-9. Morgan CW, Diaz JE, Zeitlin SG, Gray DC, Wells JA. PMID: 26106156.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    50. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18590-5. Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. PMID: 25518860.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    51. An improved single-chain Fab platform for efficient display and recombinant expression. J Mol Biol. 2015 Jan 30; 427(2):576-86. Koerber JT, Hornsby MJ, Wells JA. PMID: 25481745.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    52. In amnio MRI of mouse embryos. PLoS One. 2014; 9(10):e109143. Roberts TA, Norris FC, Carnaghan H, Savery D, Wells JA, Siow B, Scambler PJ, Pierro A, De Coppi P, Eaton S, Lythgoe MF. PMID: 25330230.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    53. Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Mol Cell. 2014 Nov 06; 56(3):360-75. Ordureau A, Sarraf SA, Duda DM, Heo JM, Jedrychowski MP, Sviderskiy VO, Olszewski JL, Koerber JT, Xie T, Beausoleil SA, Wells JA, Gygi SP, Schulman BA, Harper JW. PMID: 25284222.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansCells
    54. Unraveling the mechanism of cell death induced by chemical fibrils. Nat Chem Biol. 2014 Nov; 10(11):969-76. Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. PMID: 25262416.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    55. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. Chem Biol. 2014 Sep 18; 21(9):1102-14. Arkin MR, Tang Y, Wells JA. PMID: 25237857.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansCells
    56. Cell biology. New tricks for an old dimer. Science. 2014 May 16; 344(6185):703-4. Wells JA, Kossiakoff AA. PMID: 24833381.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    57. Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):7594-9. Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA. PMID: 24821784.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    58. FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions. Medchemcomm. 2014 Mar 01; 5:370-375. Lodge JM, Rettenmaier TJ, Wells JA, Pomerantz WC, Mapp AK. PMID: 24795804.
      View in: PubMed   Mentions:
    59. Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini. Methods Enzymol. 2014; 544:327-58. Wiita AP, Seaman JE, Wells JA. PMID: 24974296.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    60. Methods in Enzymology. Regulated cell death part B--necroptotic, autophagic and other non-apoptotic mechanisms. Preface. Methods Enzymol. 2014; 545:xiii. Ashkenazi A, Wells JA, Yuan J. PMID: 25065895.
      View in: PubMed   Mentions:    Fields:    
    61. Turning on caspases with genetics and small molecules. Methods Enzymol. 2014; 544:179-213. Morgan CW, Julien O, Unger EK, Shah NM, Wells JA. PMID: 24974291.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    62. Regulated cell death part A: apoptotic mechanisms. Preface. Methods Enzymol. 2014; 544:xv. Ashkenazi A, Yuan J, Wells JA. PMID: 24974300.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    63. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28; 503(7477):548-51. Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. PMID: 24256730.
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    64. Global cellular response to chemotherapy-induced apoptosis. Elife. 2013 Oct 29; 2:e01236. Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA. PMID: 24171104.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    65. Nature-inspired design of motif-specific antibody scaffolds. Nat Biotechnol. 2013 Oct; 31(10):916-21. Koerber JT, Thomsen ND, Hannigan BT, Degrado WF, Wells JA. PMID: 23955275.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    66. Next generation therapeutics. Curr Opin Chem Biol. 2013 Jun; 17(3):317-9. Carter PJ, Hazuda D, Wells JA. PMID: 23683350.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    67. Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8477-82. Thomsen ND, Koerber JT, Wells JA. PMID: 23650375.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    68. Ordering a dynamic protein via a small-molecule stabilizer. J Am Chem Soc. 2013 Mar 06; 135(9):3363-6. Wang N, Majmudar CY, Pomerantz WC, Gagnon JK, Sadowsky JD, Meagher JL, Johnson TK, Stuckey JA, Brooks CL, Wells JA, Mapp AK. PMID: 23384013.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    69. Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. J Biol Chem. 2013 Apr 05; 288(14):9971-81. Datta D, McClendon CL, Jacobson MP, Wells JA. PMID: 23386603.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    70. The DegraBase: a database of proteolysis in healthy and apoptotic human cells. Mol Cell Proteomics. 2013 Mar; 12(3):813-24. Crawford ED, Seaman JE, Agard N, Hsu GW, Julien O, Mahrus S, Nguyen H, Shimbo K, Yoshihara HA, Zhuang M, Chalkley RJ, Wells JA. PMID: 23264352.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    71. Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Mol Cell. 2013 Jan 24; 49(2):273-82. Zhuang M, Guan S, Wang H, Burlingame AL, Wells JA. PMID: 23201124.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    72. Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Cell Death Differ. 2012 Dec; 19(12):2040-8. Crawford ED, Seaman JE, Barber AE, David DC, Babbitt PC, Burlingame AL, Wells JA. PMID: 22918439.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    73. Fibrils colocalize caspase-3 with procaspase-3 to foster maturation. J Biol Chem. 2012 Sep 28; 287(40):33781-95. Zorn JA, Wolan DW, Agard NJ, Wells JA. PMID: 22872644.
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    74. Quantitative profiling of caspase-cleaved substrates reveals different drug-induced and cell-type patterns in apoptosis. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12432-7. Shimbo K, Hsu GW, Nguyen H, Mahrus S, Trinidad JC, Burlingame AL, Wells JA. PMID: 22802652.
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    75. Global kinetic analysis of proteolysis via quantitative targeted proteomics. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):1913-8. Agard NJ, Mahrus S, Trinidad JC, Lynn A, Burlingame AL, Wells JA. PMID: 22308409.
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    76. Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair. J Orthop Res. 2012 Jul; 30(7):1095-102. Liu F, Porter RM, Wells J, Glatt V, Pilapil C, Evans CH. PMID: 22213093.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    77. Identification of specific tethered inhibitors for caspase-5. Chem Biol Drug Des. 2012 Feb; 79(2):209-15. Gao J, Wells JA. PMID: 22014003.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    78. Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation. J Am Chem Soc. 2011 Dec 14; 133(49):19630-3. Zorn JA, Wille H, Wolan DW, Wells JA. PMID: 22066605.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    79. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J Biol Chem. 2011 Sep 30; 286(39):34147-54. Tang Y, Wells JA, Arkin MR. PMID: 21828056.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    80. Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6056-61. Sadowsky JD, Burlingame MA, Wolan DW, McClendon CL, Jacobson MP, Wells JA. PMID: 21430264.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    81. Caspase substrates and cellular remodeling. Annu Rev Biochem. 2011; 80:1055-87. Crawford ED, Wells JA. PMID: 21456965.
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    82. Activation of specific apoptotic caspases with an engineered small-molecule-activated protease. Cell. 2010 Aug 20; 142(4):637-46. Gray DC, Mahrus S, Wells JA. PMID: 20723762.
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    83. Prediction of protease substrates using sequence and structure features. Bioinformatics. 2010 Jul 15; 26(14):1714-22. Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A. PMID: 20505003.
      View in: PubMed   Mentions: 23     Fields:    
    84. Turning enzymes ON with small molecules. Nat Chem Biol. 2010 Mar; 6(3):179-188. Zorn JA, Wells JA. PMID: 20154666.
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    85. Inflammatory stimuli regulate caspase substrate profiles. Mol Cell Proteomics. 2010 May; 9(5):880-93. Agard NJ, Maltby D, Wells JA. PMID: 20173201.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    86. Sampling the N-terminal proteome of human blood. Proc Natl Acad Sci U S A. 2010 Mar 09; 107(10):4561-6. Wildes D, Wells JA. PMID: 20173099.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    87. Molecules that modulate Apaf-1 activity. Med Res Rev. 2011 Jul; 31(4):649-75. Pérez-Payá E, Orzáez M, Mondragón L, Wolan D, Wells JA, Messeguer A, Vicent MJ. PMID: 20099266.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    88. Warren L. DeLano 21 June 1972-3 November 2009. Nat Struct Mol Biol. 2009 Dec; 16(12):1202-3. Brunger AT, Wells JA. PMID: 19956203.
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    89. Small-molecule activators of a proenzyme. Science. 2009 Nov 06; 326(5954):853-8. Wolan DW, Zorn JA, Gray DC, Wells JA. PMID: 19892984.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    90. Methods for the proteomic identification of protease substrates. Curr Opin Chem Biol. 2009 Dec; 13(5-6):503-9. Agard NJ, Wells JA. PMID: 19729334.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    91. Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. J Biol Chem. 2009 Sep 18; 284(38):26063-9. Hardy JA, Wells JA. PMID: 19581639.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    92. Two-state selection of conformation-specific antibodies. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3071-6. Gao J, Sidhu SS, Wells JA. PMID: 19208804.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    93. Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini. Cell. 2008 Sep 05; 134(5):866-76. Mahrus S, Trinidad JC, Barkan DT, Sali A, Burlingame AL, Wells JA. PMID: 18722006.
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    94. Tags for labeling protein N-termini with subtiligase for proteomics. Bioorg Med Chem Lett. 2008 Nov 15; 18(22):6000-3. Yoshihara HA, Mahrus S, Wells JA. PMID: 18762420.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    95. An allosteric circuit in caspase-1. J Mol Biol. 2008 Sep 19; 381(5):1157-67. Datta D, Scheer JM, Romanowski MJ, Wells JA. PMID: 18590738.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    96. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature. 2007 Dec 13; 450(7172):1001-9. Wells JA, McClendon CL. PMID: 18075579.
      View in: PubMed   Mentions: 564     Fields:    Translation:HumansAnimalsCells
    97. Computational approach to site-directed ligand discovery. Proteins. 2007 Aug 01; 68(2):551-60. Tóth G, Mukhyala K, Wells JA. PMID: 17444517.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    98. Evaluation of technical approaches to tele-electromyography via internet protocol networks. Telemed J E Health. 2007 Feb; 13(1):33-9. Simmons SC, Moore DP, Wells J. PMID: 17309352.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    99. Diurnal variation in retinal thickening measurement by optical coherence tomography in center-involved diabetic macular edema. Arch Ophthalmol. 2006 Dec; 124(12):1701-7. Danis RP, Glassman AR, Aiello LP, Antoszyk AN, Beck RW, Browning DJ, Ciardella AP, Kinyoun JL, Murtha TJ, Topping TM, Shami M, Sharuk GS, Wells JA. PMID: 17159029.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    100. Hot-spot mimicry of a cytokine receptor by a small molecule. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15422-7. Thanos CD, DeLano WL, Wells JA. PMID: 17032757.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    101. Positive pressure ventilation with the laryngeal mask airway in the operating room and prehospital: a practical review. J Trauma. 2006 Jun; 60(6):1371-6. Matioc AA, Wells JA. PMID: 16766989.
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    102. A common allosteric site and mechanism in caspases. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7595-600. Scheer JM, Romanowski MJ, Wells JA. PMID: 16682620.
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    103. Malonate-assisted purification of human caspases. Protein Expr Purif. 2005 May; 41(1):148-53. Scheer JM, Wells JA, Romanowski MJ. PMID: 15802232.
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    104. Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2719-24. Buck E, Wells JA. PMID: 15710877.
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    105. Searching for new allosteric sites in enzymes. Curr Opin Struct Biol. 2004 Dec; 14(6):706-15. Hardy JA, Wells JA. PMID: 15582395.
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    106. Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor. J Biol Chem. 2005 Feb 11; 280(6):4009-12. Buck E, Bourne H, Wells JA. PMID: 15550394.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    107. Discovery of an allosteric site in the caspases. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12461-6. Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA. PMID: 15314233.
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    108. Apo cytochrome c inhibits caspases by preventing apoptosome formation. Biochem Biophys Res Commun. 2004 Jul 02; 319(3):944-50. Martin AG, Nguyen J, Wells JA, Fearnhead HO. PMID: 15184073.
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    109. Mechanistic diversity of cytokine receptor signaling across cell membranes. Sci STKE. 2004 Apr 28; 2004(231):re7. Stroud RM, Wells JA. PMID: 15126678.
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    110. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov. 2004 Apr; 3(4):301-17. Arkin MR, Wells JA. PMID: 15060526.
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    111. Tethering: fragment-based drug discovery. Annu Rev Biophys Biomol Struct. 2004; 33:199-223. Erlanson DA, Wells JA, Braisted AC. PMID: 15139811.
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    112. Potent small-molecule binding to a dynamic hot spot on IL-2. J Am Chem Soc. 2003 Dec 17; 125(50):15280-1. Thanos CD, Randal M, Wells JA. PMID: 14664558.
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    113. Propylene glycol-associated renal toxicity from lorazepam infusion. Pharmacotherapy. 2003 Sep; 23(9):1094-9. Yaucher NE, Fish JT, Smith HW, Wells JA. PMID: 14524641.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    114. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7533-8. Nguyen JT, Wells JA. PMID: 12808146.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    115. Binding of small molecules to an adaptive protein-protein interface. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1603-8. Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. PMID: 12582206.
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    116. Drug discovery at signaling interfaces. Ernst Schering Res Found Workshop. 2003; (42):19-27. Wells J, Arkin M, Braisted A, DeLano W, McDowell B, Oslob J, Raimundo B, Randal M. PMID: 12664533.
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    117. BVA governance. Vet Rec. 2002 Aug 24; 151(8):247; author reply 247. Johnson B, Gorman NT, Hird JF, Wadsworth DE, Wells JA, Dyson SJ, Bleby J. PMID: 12219907.
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    118. Nocturnal polyuria in type 2 diabetes: a symptom of obstructive sleep apnea. Diabetes Educ. 2002 May-Jun; 28(3):424-34. Chasens ER, Umlauf MG, Pillion DJ, Wells JA. PMID: 12068651.
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    119. The LMA-unique in a prehospital trauma patient: interaction with a semirigid cervical collar: a case report. J Trauma. 2002 Jan; 52(1):162-4. Matioc AA, Wells JA. PMID: 11791069.
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    120. Acute barium poisoning treated with hemodialysis. Am J Emerg Med. 2001 Mar; 19(2):175-7. Wells JA, Wood KE. PMID: 11239275.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    121. Metabolic databases - what next? Trends Biochem Sci. 2001 Feb; 26(2):137-40. Gerrard JA, Sparrow AD, Wells JA. PMID: 11166573.
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    122. Site-directed ligand discovery. Proc Natl Acad Sci U S A. 2000 Aug 15; 97(17):9367-72. Erlanson DA, Braisted AC, Raphael DR, Randal M, Stroud RM, Gordon EM, Wells JA. PMID: 10944209.
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    123. Mutational analysis of the major coat protein of M13 identifies residues that control protein display. Protein Sci. 2000 Apr; 9(4):647-54. Weiss GA, Wells JA, Sidhu SS. PMID: 10794407.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    124. High copy display of large proteins on phage for functional selections. J Mol Biol. 2000 Feb 18; 296(2):487-95. Sidhu SS, Weiss GA, Wells JA. PMID: 10669603.
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    125. Convergent solutions to binding at a protein-protein interface. Science. 2000 Feb 18; 287(5456):1279-83. DeLano WL, Ultsch MH, de Vos AM, Wells JA. PMID: 10678837.
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    126. Phage display for selection of novel binding peptides. Methods Enzymol. 2000; 328:333-63. Sidhu SS, Lowman HB, Cunningham BC, Wells JA. PMID: 11075354.
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    127. Urinary incontinence in a geriatric patient with a complex neurologic history. J Wound Ostomy Continence Nurs. 1999 Sep; 26(5):270-4; discussion 274-5. Wells JA, Ouslander JG, Meadows E, Johnson VY. PMID: 10795211.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    128. Selection for improved subtiligases by phage display. Proc Natl Acad Sci U S A. 1999 Aug 17; 96(17):9497-502. Atwell S, Wells JA. PMID: 10449721.
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    129. Growth hormone binding affinity for its receptor surpasses the requirements for cellular activity. Biochemistry. 1999 Jan 05; 38(1):81-9. Pearce KH, Cunningham BC, Fuh G, Teeri T, Wells JA. PMID: 9890885.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    130. Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site. Biochemistry. 1998 Dec 22; 37(51):17754-64. Fairbrother WJ, Christinger HW, Cochran AG, Fuh G, Keenan CJ, Quan C, Shriver SK, Tom JY, Wells JA, Cunningham BC. PMID: 9922141.
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    131. Probing the importance of second sphere residues in an esterolytic antibody by phage display. J Mol Biol. 1998 Dec 11; 284(4):1083-94. Arkin MR, Wells JA. PMID: 9837728.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    132. Will any dimer do? Nat Struct Biol. 1998 Nov; 5(11):938-40. Ballinger MD, Wells JA. PMID: 9808034.
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    133. Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis. J Biol Chem. 1998 May 08; 273(19):11667-74. Jones JT, Ballinger MD, Pisacane PI, Lofgren JA, Fitzpatrick VD, Fairbrother WJ, Wells JA, Sliwkowski MX. PMID: 9565587.
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    134. Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display. J Biol Chem. 1998 May 08; 273(19):11675-84. Ballinger MD, Jones JT, Lofgren JA, Fairbrother WJ, Akita RW, Sliwkowski MX, Wells JA. PMID: 9565588.
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    135. Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor. J Biol Chem. 1998 May 01; 273(18):11197-204. Fuh G, Li B, Crowley C, Cunningham B, Wells JA. PMID: 9556609.
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    136. Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity. J Mol Biol. 1998 Apr 17; 277(5):1111-28. Clackson T, Ultsch MH, Wells JA, de Vos AM. PMID: 9571026.
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    137. Interface pressure, wound healing, and satisfaction in the evaluation of a non-powered fluid mattress. Ostomy Wound Manage. 1998 Feb; 44(2):38-42, 44-6, 48 passim. Wells JA, Karr D. PMID: 9526420.
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    138. Incidence of idiopathic full-thickness macular holes in fellow eyes. A 5-year prospective natural history study. Ophthalmology. 1998 Feb; 105(2):353-9. Ezra E, Wells JA, Gray RH, Kinsella FM, Orr GM, Grego J, Arden GB, Gregor ZJ. PMID: 9479299.
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    139. Surgical removal of non-age-related subfoveal choroidal neovascular membranes. Eye (Lond). 1998; 12 ( Pt 5):775-80. Eckstein M, Wells JA, Aylward B, Gregor Z. PMID: 10070507.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    140. Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor. Cell. 1997 Nov 28; 91(5):695-704. Wiesmann C, Fuh G, Christinger HW, Eigenbrot C, Wells JA, de Vos AM. PMID: 9393862.
      View in: PubMed   Mentions: 91     Fields:    Translation:Cells
    141. Structural plasticity in a remodeled protein-protein interface. Science. 1997 Nov 07; 278(5340):1125-8. Atwell S, Ultsch M, De Vos AM, Wells JA. PMID: 9353194.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    142. Phage display of a catalytic antibody to optimize affinity for transition-state analog binding. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10063-8. Baca M, Scanlan TS, Stephenson RC, Wells JA. PMID: 9294163.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    143. Structural mimicry of a native protein by a minimized binding domain. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10080-5. Starovasnik MA, Braisted AC, Wells JA. PMID: 9294166.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    144. Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci. 1997 Sep; 6(9):1806-24. Scheidig AJ, Hynes TR, Pelletier LA, Wells JA, Kossiakoff AA. PMID: 9300481.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    145. Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites. J Biol Chem. 1997 Aug 15; 272(33):20595-602. Pearce KH, Potts BJ, Presta LG, Bald LN, Fendly BM, Wells JA. PMID: 9252374.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    146. Minimized proteins. Curr Opin Struct Biol. 1997 Aug; 7(4):457-62. Cunningham BC, Wells JA. PMID: 9266165.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    147. Song development by grey catbirds Anim Behav. 1997 Aug; 54(2):457-64. Kroodsma DE, Houlihan PW, Fallon PA, Wells JA. PMID: 9268478.
      View in: PubMed   Mentions: 9     Fields:    
    148. Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7192-7. Muller YA, Li B, Christinger HW, Wells JA, Cunningham BC, de Vos AM. PMID: 9207067.
      View in: PubMed   Mentions: 84     Fields:    Translation:Cells
    149. Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library. J Mol Biol. 1997 Jul 04; 270(1):26-35. Atwell S, Ridgway JB, Wells JA, Carter P. PMID: 9231898.
      View in: PubMed   Mentions: 54     Fields:    Translation:Cells
    150. Antibody humanization using monovalent phage display. J Biol Chem. 1997 Apr 18; 272(16):10678-84. Baca M, Presta LG, O'Connor SJ, Wells JA. PMID: 9099717.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    151. Synthesis of proteins by subtiligase. Methods Enzymol. 1997; 289:298-313. Braisted AC, Judice JK, Wells JA. PMID: 9353727.
      View in: PubMed   Mentions: 14     Fields:    
    152. Furilisin: a variant of subtilisin BPN' engineered for cleaving tribasic substrates. Biochemistry. 1996 Oct 22; 35(42):13579-85. Ballinger MD, Tom J, Wells JA. PMID: 8885837.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    153. Long-acting growth hormones produced by conjugation with polyethylene glycol. J Biol Chem. 1996 Sep 06; 271(36):21969-77. Clark R, Olson K, Fuh G, Marian M, Mortensen D, Teshima G, Chang S, Chu H, Mukku V, Canova-Davis E, Somers T, Cronin M, Winkler M, Wells JA. PMID: 8703002.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    154. Structural and mutational analysis of affinity-inert contact residues at the growth hormone-receptor interface. Biochemistry. 1996 Aug 13; 35(32):10300-7. Pearce KH, Ultsch MH, Kelley RF, de Vos AM, Wells JA. PMID: 8756685.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    155. Hormone mimicry. Science. 1996 Jul 26; 273(5274):449-50. Wells JA. PMID: 8677438.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    156. Minimizing a binding domain from protein A. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):5688-92. Braisted AC, Wells JA. PMID: 8650153.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    157. Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisation. Br J Ophthalmol. 1996 Apr; 80(4):363-6. Wells JA, Murthy R, Chibber R, Nunn A, Molinatti PA, Kohner EM, Gregor ZJ. PMID: 8703891.
      View in: PubMed   Mentions: 40     Fields:    Translation:Humans
    158. Binding in the growth hormone receptor complex. Proc Natl Acad Sci U S A. 1996 Jan 09; 93(1):1-6. Wells JA. PMID: 8552582.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    159. Hematopoietic receptor complexes. Annu Rev Biochem. 1996; 65:609-34. Wells JA, de Vos AM. PMID: 8811191.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    160. Surgical treatment of full-thickness macular holes using autologous serum. Eye (Lond). 1996; 10 ( Pt 5):593-9. Wells JA, Gregor ZJ. PMID: 8977788.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    161. Minimization of a polypeptide hormone. Science. 1995 Dec 08; 270(5242):1657-60. Li B, Tom JY, Oare D, Yen R, Fairbrother WJ, Wells JA, Cunningham BC. PMID: 7502074.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    162. Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group. N Engl J Med. 1995 Oct 26; 333(17):1093-8. Goddard AD, Covello R, Luoh SM, Clackson T, Attie KM, Gesundheit N, Rundle AC, Wells JA, Carlsson LM. PMID: 7565946.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    163. Designing subtilisin BPN' to cleave substrates containing dibasic residues. Biochemistry. 1995 Oct 17; 34(41):13312-9. Ballinger MD, Tom J, Wells JA. PMID: 7577915.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    164. Structural and functional epitopes in the growth hormone receptor complex. Biotechnology (N Y). 1995 Jul; 13(7):647-51. Wells JA. PMID: 9634801.
      View in: PubMed   Mentions: 3     Fields:    
    165. Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines. J Biol Chem. 1995 Jun 02; 270(22):13133-7. Fuh G, Wells JA. PMID: 7768908.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    166. The prevalence of homosexual behavior and attraction in the United States, the United Kingdom and France: results of national population-based samples. Arch Sex Behav. 1995 Jun; 24(3):235-48. Sell RL, Wells JA, Wypij D. PMID: 7611844.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    167. A hot spot of binding energy in a hormone-receptor interface. Science. 1995 Jan 20; 267(5196):383-6. Clackson T, Wells JA. PMID: 7529940.
      View in: PubMed   Mentions: 530     Fields:    Translation:HumansCells
    168. Subtiligase: a tool for semisynthesis of proteins. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12544-8. Chang TK, Jackson DY, Burnier JP, Wells JA. PMID: 7809074.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    169. Readability of HIV/AIDS educational materials: the role of the medium of communication, target audience, and producer characteristics. Patient Educ Couns. 1994 Dec; 24(3):249-59. Wells JA. PMID: 7753718.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    170. Dissecting the energetics of an antibody-antigen interface by alanine shaving and molecular grafting. Protein Sci. 1994 Dec; 3(12):2351-7. Jin L, Wells JA. PMID: 7538848.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    171. Ocular findings associated with a 3 base pair deletion in the peripherin-RDS gene in autosomal dominant retinitis pigmentosa. Br J Ophthalmol. 1994 Nov; 78(11):831-6. Wroblewski JJ, Wells JA, Eckstein A, Fitzke FW, Jubb C, Keen TJ, Inglehearn CF, Bhattacharya SS, Arden GB, Jay MR. PMID: 7848979.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    172. A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues. Science. 1994 Oct 14; 266(5183):243-7. Jackson DY, Burnier J, Quan C, Stanley M, Tom J, Wells JA. PMID: 7939659.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    173. Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors. Ophthalmology. 1994 Sep; 101(9):1522-8. Holz FG, Wolfensberger TJ, Piguet B, Gross-Jendroska M, Wells JA, Minassian DC, Chisholm IH, Bird AC. PMID: 8090455.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    174. Engineering an interfacial zinc site to increase hormone-receptor affinity. Chem Biol. 1994 Sep; 1(1):25-30. Matthews DJ, Wells JA. PMID: 9383367.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    175. A survey of furin substrate specificity using substrate phage display. Protein Sci. 1994 Aug; 3(8):1197-205. Matthews DJ, Goodman LJ, Gorman CM, Wells JA. PMID: 7987214.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    176. Pouching principles and products. Ostomy Wound Manage. 1994 Jul-Aug; 40(6):50-8, 60-3. Wells JA, Doughty DB. PMID: 7880372.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    177. Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes. Endocrinology. 1994 Jun; 134(6):2397-403. Ilondo MM, Damholt AB, Cunningham BA, Wells JA, De Meyts P, Shymko RM. PMID: 8194466.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    178. Production of an atrial natriuretic peptide variant that is specific for type A receptor. EMBO J. 1994 Jun 01; 13(11):2508-15. Cunningham BC, Lowe DG, Li B, Bennett BD, Wells JA. PMID: 8013451.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    179. In vitro selection of zinc fingers with altered DNA-binding specificity. Biochemistry. 1994 May 17; 33(19):5689-95. Jamieson AC, Kim SH, Wells JA. PMID: 8180194.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    180. A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4110-4. Wells JA, Fairbrother WJ, Otlewski J, Laskowski M, Burnier J. PMID: 8183880.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    181. The stoichiometry of growth hormone-binding protein complexes in human plasma: comparison with cell surface receptors. J Clin Endocrinol Metab. 1994 May; 78(5):1113-8. Baumann G, Lowman HB, Mercado M, Wells JA. PMID: 8175967.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    182. Literacy of women attending family planning clinics in Virginia and reading levels of brochures on HIV prevention. Fam Plann Perspect. 1994 May-Jun; 26(3):113-5, 131. Wells JA, Ruscavage D, Parker B, McArthur L. PMID: 8070547.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    183. A second-generation study of 427 probands with congenital heart defects and their 837 children. J Am Coll Cardiol. 1994 May; 23(6):1459-67. Whittemore R, Wells JA, Castellsague X. PMID: 8176107.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    184. In vitro selection from protein and peptide libraries. Trends Biotechnol. 1994 May; 12(5):173-84. Clackson T, Wells JA. PMID: 7764900.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    185. Corneal opacities in spondyloepiphyseal dysplasia tarda. Cornea. 1994 May; 13(3):280-3. Wells JA, Ellerine NP, Fernhoff PM, Waring GO. PMID: 8033583.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    186. Structural and functional basis for hormone binding and receptor oligomerization. Curr Opin Cell Biol. 1994 Apr; 6(2):163-73. Wells JA. PMID: 8024806.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    187. Structure from function: screening structural models with functional data. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):113-7. Jin L, Cohen FE, Wells JA. PMID: 7506411.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    188. Macular dystrophy associated with mutations at codon 172 in the human retinal degeneration slow gene. Ophthalmology. 1994 Jan; 101(1):12-22. Wroblewski JJ, Wells JA, Eckstein A, Fitzke F, Jubb C, Keen TJ, Inglehearn C, Bhattacharya S, Arden GB, Jay M. PMID: 8302543.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    189. Affinity maturation of human growth hormone by monovalent phage display. J Mol Biol. 1993 Dec 05; 234(3):564-78. Lowman HB, Wells JA. PMID: 8254660.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    190. Comparison of a structural and a functional epitope. J Mol Biol. 1993 Dec 05; 234(3):554-63. Cunningham BC, Wells JA. PMID: 7504735.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansCells
    191. Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland. Endocrinology. 1993 Oct; 133(4):1602-8. Feldman M, Ruan W, Cunningham BC, Wells JA, Kleinberg DL. PMID: 8404600.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    192. Age-related Bruch's membrane change: a clinical study of the relative role of heredity and environment. Br J Ophthalmol. 1993 Jul; 77(7):400-3. Piguet B, Wells JA, Palmvang IB, Wormald R, Chisholm IH, Bird AC. PMID: 8343465.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansPHPublic Health
    193. Substrate phage: selection of protease substrates by monovalent phage display. Science. 1993 May 21; 260(5111):1113-7. Matthews DJ, Wells JA. PMID: 8493554.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    194. Mechanism-based design of prolactin receptor antagonists. J Biol Chem. 1993 Mar 15; 268(8):5376-81. Fuh G, Colosi P, Wood WI, Wells JA. PMID: 8449901.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    195. Structure and function of human growth hormone: implications for the hematopoietins. Annu Rev Biophys Biomol Struct. 1993; 22:329-51. Wells JA, de Vos AM. PMID: 7688610.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    196. The molecular basis for growth hormone-receptor interactions. Recent Prog Horm Res. 1993; 48:253-75. Wells JA, Cunningham BC, Fuh G, Lowman HB, Bass SH, Mulkerrin MG, Ultsch M, deVos AM. PMID: 8441850.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    197. Health behavior changes in the United States, the United Kingdom, and France. J Gen Intern Med. 1992 Nov-Dec; 7(6):615-22. Retchin SM, Wells JA, Valleron AJ, Albrecht GL. PMID: 1453245.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    198. Immunodominant structures of human growth hormone identified by homolog-scanning mutagenesis. Mol Immunol. 1992 Sep; 29(9):1081-8. Weber JR, Nelson C, Cunningham BC, Wells JA, Fong S. PMID: 1495498.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    199. Incorporation of a stabilizing Ca(2+)-binding loop into subtilisin BPN'. Biochemistry. 1992 Sep 01; 31(34):7796-801. Braxton S, Wells JA. PMID: 1510966.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    200. High resolution functional analysis of antibody-antigen interactions. J Mol Biol. 1992 Aug 05; 226(3):851-65. Jin L, Fendly BM, Wells JA. PMID: 1380563.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    201. Rapid evolution of peptide and protein binding properties in vitro. Curr Opin Biotechnol. 1992 Aug; 3(4):355-62. Wells JA, Lowman HB. PMID: 1368436.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    202. Prevalence of obesity: a comparative survey in France, the United Kingdom and the United States. Int J Obes Relat Metab Disord. 1992 Aug; 16(8):565-72. Laurier D, Guiguet M, Chau NP, Wells JA, Valleron AJ. PMID: 1326486.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    203. Effect of aging and exercise on GLUT-4 glucose transporters in muscle. Am J Physiol. 1992 Aug; 263(2 Pt 1):E362-7. Kern M, Dolan PL, Mazzeo RS, Wells JA, Dohm GL. PMID: 1514619.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    204. Rational design of potent antagonists to the human growth hormone receptor. Science. 1992 Jun 19; 256(5064):1677-80. Fuh G, Cunningham BC, Fukunaga R, Nagata S, Goeddel DV, Wells JA. PMID: 1535167.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    205. Growth hormone augments superoxide anion secretion of human neutrophils by binding to the prolactin receptor. J Clin Invest. 1992 Feb; 89(2):451-7. Fu YK, Arkins S, Fuh G, Cunningham BC, Wells JA, Fong S, Cronin MJ, Dantzer R, Kelley KW. PMID: 1310696.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    206. [Prevalence of obesity in France]. Rev Epidemiol Sante Publique. 1992; 40(5):365-7. Laurier D, Guiguet M, Chau NP, Wells JA, Valleron AJ. PMID: 1480813.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    207. Keratoconus associated with posterior polymorphous dystrophy. Am J Ophthalmol. 1991 Dec 15; 112(6):729-31. Bechara SJ, Grossniklaus HE, Waring GO, Wells JA. PMID: 1957913.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    208. Selecting high-affinity binding proteins by monovalent phage display. Biochemistry. 1991 Nov 12; 30(45):10832-8. Lowman HB, Bass SH, Simpson N, Wells JA. PMID: 1932005.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    209. Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science. 1991 Nov 08; 254(5033):821-5. Cunningham BC, Ultsch M, De Vos AM, Mulkerrin MG, Clauser KR, Wells JA. PMID: 1948064.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansCells
    210. Dimerization of human growth hormone by zinc. Science. 1991 Aug 02; 253(5019):545-8. Cunningham BC, Mulkerrin MG, Wells JA. PMID: 1907025.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    211. French intravenous drug users: knowledge and sexual behavior change. Eur J Epidemiol. 1991 Jul; 7(4):423-6. Guiguet M, Cohen M, Flahault A, Wells JA, Valleron AJ. PMID: 1915793.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    212. The importance of a distal hydrogen bonding group in stabilizing the transition state in subtilisin BPN'. J Biol Chem. 1991 Jun 25; 266(18):11797-800. Braxton S, Wells JA. PMID: 1904870.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    213. Probing the mechanism and improving the rate of substrate-assisted catalysis in subtilisin BPN'. Biochemistry. 1991 Jun 25; 30(25):6142-8. Carter P, Abrahmsén L, Wells JA. PMID: 2059622.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    214. Mutational analysis and protein engineering of receptor-binding determinants in human placental lactogen. J Biol Chem. 1991 Jun 15; 266(17):10982-8. Lowman HB, Cunningham BC, Wells JA. PMID: 2040614.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    215. A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4498-502. Bass SH, Mulkerrin MG, Wells JA. PMID: 2034689.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    216. Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution. Biochemistry. 1991 Apr 30; 30(17):4151-9. Abrahmsén L, Tom J, Burnier J, Butcher KA, Kossiakoff A, Wells JA. PMID: 2021606.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    217. Rational design of receptor-specific variants of human growth hormone. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):3407-11. Cunningham BC, Wells JA. PMID: 2014261.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    218. Systematic mutational analyses of protein-protein interfaces. Methods Enzymol. 1991; 202:390-411. Wells JA. PMID: 1723781.
      View in: PubMed   Mentions: 97     Fields:    Translation:Cells
    219. Zinc mediation of the binding of human growth hormone to the human prolactin receptor. Science. 1990 Dec 21; 250(4988):1709-12. Cunningham BC, Bass S, Fuh G, Wells JA. PMID: 2270485.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    220. Additivity of mutational effects in proteins. Biochemistry. 1990 Sep 18; 29(37):8509-17. Wells JA. PMID: 2271534.
      View in: PubMed   Mentions: 164     Fields:    Translation:Cells
    221. Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level. Biochem J. 1990 Sep 01; 270(2):397-400. Kern M, Wells JA, Stephens JM, Elton CW, Friedman JE, Tapscott EB, Pekala PH, Dohm GL. PMID: 2205203.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    222. Increased glucose transporter (GLUT4) protein expression in hyperthyroidism. Biochem Biophys Res Commun. 1990 Aug 31; 171(1):182-8. Casla A, Rovira A, Wells JA, Dohm GL. PMID: 2203344.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    223. The role of lysine-234 in beta-lactamase catalysis probed by site-directed mutagenesis. Biochemistry. 1990 Jun 19; 29(24):5797-806. Ellerby LM, Escobar WA, Fink AL, Mitchinson C, Wells JA. PMID: 1974463.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    224. Engineering human prolactin to bind to the human growth hormone receptor. Science. 1990 Mar 23; 247(4949 Pt 1):1461-5. Cunningham BC, Henner DJ, Wells JA. PMID: 2321008.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    225. The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain. J Biol Chem. 1990 Feb 25; 265(6):3111-5. Fuh G, Mulkerrin MG, Bass S, McFarland N, Brochier M, Bourell JH, Light DR, Wells JA. PMID: 2406245.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    226. The effect of fasting on the activation in vivo of the insulin receptor kinase. Biochem J. 1990 Feb 01; 265(3):887-90. Contreras I, Dohm GL, Abdallah S, Wells JA, Mooney N, Rovira A, Caro JF. PMID: 2407238.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    227. Part I: The NGRI Registry: initial analyses of data collected on Connecticut insanity acquittees. Bull Am Acad Psychiatry Law. 1990; 18(2):115-28. Zonana HV, Wells JA, Getz MA, Buchanan J. PMID: 2372573.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    228. Part II: Sex differences in persons found not guilty by reason of insanity: analysis of data from the Connecticut NGRI Registry. Bull Am Acad Psychiatry Law. 1990; 18(2):129-42. Zonana HV, Bartel RL, Wells JA, Buchanan JA, Getz MA. PMID: 2372574.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    229. Respiratory rate during acute asthma. Chest. 1990 Jan; 97(1):58-62. Kesten S, Maleki-Yazdi R, Sanders BR, Wells JA, McKillop SL, Chapman KR, Rebuck AS. PMID: 2403901.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    230. Functional interaction among catalytic residues in subtilisin BPN'. Proteins. 1990; 7(4):335-42. Carter P, Wells JA. PMID: 2199971.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    231. Identification and design of binding determinants in proteins. Biochem Soc Symp. 1990; 57:143-5. Wells JA, Cunningham BC. PMID: 2099738.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    232. Hormone phage: an enrichment method for variant proteins with altered binding properties. Proteins. 1990; 8(4):309-14. Bass S, Greene R, Wells JA. PMID: 1708882.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    233. High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science. 1989 Jun 02; 244(4908):1081-5. Cunningham BC, Wells JA. PMID: 2471267.
      View in: PubMed   Mentions: 363     Fields:    Translation:HumansCells
    234. Protein engineering of disulfide bonds in subtilisin BPN'. Biochemistry. 1989 May 30; 28(11):4807-15. Mitchinson C, Wells JA. PMID: 2504281.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    235. Changes in glucose transporters in muscle in response to exercise. Am J Physiol. 1989 May; 256(5 Pt 1):E580-7. Fushiki T, Wells JA, Tapscott EB, Dohm GL. PMID: 2655468.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    236. Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis. Science. 1989 Mar 10; 243(4896):1330-6. Cunningham BC, Jhurani P, Ng P, Wells JA. PMID: 2466339.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    237. Engineering subtilisin BPN' for site-specific proteolysis. Proteins. 1989; 6(3):240-8. Carter P, Nilsson B, Burnier JP, Burdick D, Wells JA. PMID: 2516317.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    238. The influence of source of insurance coverage on the health care utilization patterns of the elderly. J Health Hum Resour Adm. 1989; 11(3):285-311. Dunlop BD, Wells JA, Wilensky GR. PMID: 10303344.
      View in: PubMed   Mentions:
    239. Subtilisin--an enzyme designed to be engineered. Trends Biochem Sci. 1988 Aug; 13(8):291-7. Wells JA, Estell DA. PMID: 3154281.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    240. Dissecting the catalytic triad of a serine protease. Nature. 1988 Apr 07; 332(6164):564-8. Carter P, Wells JA. PMID: 3282170.
      View in: PubMed   Mentions: 112     Fields:    Translation:Cells
    241. GrantWatch. Foundation funding for AIDS education. Health Aff (Millwood). 1988; 7(5):146-58. Wells JA, Zuercher A, Clinton J. PMID: 3229713.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    242. Recruitment of substrate-specificity properties from one enzyme into a related one by protein engineering. Proc Natl Acad Sci U S A. 1987 Aug; 84(15):5167-71. Wells JA, Cunningham BC, Graycar TP, Estell DA. PMID: 3299378.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    243. Improvement in the alkaline stability of subtilisin using an efficient random mutagenesis and screening procedure. Protein Eng. 1987 Aug-Sep; 1(4):319-25. Cunningham BC, Wells JA. PMID: 3334089.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    244. Engineering enzyme specificity by "substrate-assisted catalysis". Science. 1987 Jul 24; 237(4813):394-9. Carter P, Wells JA. PMID: 3299704.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    245. Patient age distribution in thalassemia major: changes from 1973 to 1985. Pediatrics. 1987 Jul; 80(1):53-7. Pearson HA, Guiliotis DK, Rink L, Wells JA. PMID: 3601518.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    246. Designing substrate specificity by protein engineering of electrostatic interactions. Proc Natl Acad Sci U S A. 1987 Mar; 84(5):1219-23. Wells JA, Powers DB, Bott RR, Graycar TP, Estell DA. PMID: 3547407.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    247. Foundation funding for AIDS programs. Health Aff (Millwood). 1987; 6(3):113-23. Wells JA. PMID: 3679069.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    248. On the evolution of specificity and catalysis in subtilisin. Cold Spring Harb Symp Quant Biol. 1987; 52:647-52. Wells JA, Cunningham BC, Graycar TP, Estell DA, Carter P. PMID: 3331349.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    249. Thoracoabdominal motion in response to treadmill and cycle exercise. Am Rev Respir Dis. 1986 Dec; 134(6):1125-8. Wells JA, Smyth RJ, Rebuck AS. PMID: 3098144.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    250. Probing steric and hydrophobic effects on enzyme-substrate interactions by protein engineering. Science. 1986 Aug 08; 233(4764):659-63. Estell DA, Graycar TP, Miller JV, Powers DB, Wells JA, Burnier JP, Ng PG. PMID: 17835820.
      View in: PubMed   Mentions: 27     Fields:    
    251. In vivo formation and stability of engineered disulfide bonds in subtilisin. J Biol Chem. 1986 May 15; 261(14):6564-70. Wells JA, Powers DB. PMID: 3516996.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    252. Secretion and autoproteolytic maturation of subtilisin. Proc Natl Acad Sci U S A. 1986 May; 83(10):3096-100. Power SD, Adams RM, Wells JA. PMID: 3517850.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    253. 2-[(4-Azido-2-nitrophenyl)amino]ethyl triphosphate, a novel chromophoric and photoaffinity analogue of ATP. Synthesis, characterization, and interaction with myosin subfragment 1. Biochemistry. 1985 Sep 10; 24(19):5226-35. Nakamaye KL, Wells JA, Bridenbaugh RL, Okamoto Y, Yount RG. PMID: 4074691.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    254. Engineering an enzyme by site-directed mutagenesis to be resistant to chemical oxidation. J Biol Chem. 1985 Jun 10; 260(11):6518-21. Estell DA, Graycar TP, Wells JA. PMID: 3922976.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    255. Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites. Gene. 1985; 34(2-3):315-23. Wells JA, Vasser M, Powers DB. PMID: 3891521.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    256. Characterization of the properties of ethenoadenosine nucleotides bound or trapped at the active site of myosin subfragment 1. Biochemistry. 1984 Aug 14; 23(17):3994-4002. Perkins WJ, Wells JA, Yount RG. PMID: 6237680.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    257. An improved method for purifying 2',5'-oligoadenylate synthetases. J Biol Chem. 1984 Jan 25; 259(2):1363-70. Wells JA, Swyryd EA, Stark GR. PMID: 6693390.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    258. Awareness by consumers and the adoption of a new service: an HMO example. J Health Care Mark. 1984; 4(1):17-24. Griffith MJ, Wells JA. PMID: 10266249.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    259. Cloning, sequencing, and secretion of Bacillus amyloliquefaciens subtilisin in Bacillus subtilis. Nucleic Acids Res. 1983 Nov 25; 11(22):7911-25. Wells JA, Ferrari E, Henner DJ, Estell DA, Chen EY. PMID: 6316278.
      View in: PubMed   Mentions: 93     Fields:    Translation:Cells
    260. Musculoskeletal disorders among letter carriers. A comparison of weight carrying, walking & sedentary occupations. J Occup Med. 1983 Nov; 25(11):814-20. Wells JA, Zipp JF, Schuette PT, McEleney J. PMID: 6644392.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    261. Trapping of transition metal-nucleotide complexes in myosin subfragment 1 by cross-linking thiols; divalent transition metal probes of the active site. Biochemistry. 1983 Jan 18; 22(2):490-6. Dalbey RE, Wells JA, Yount RG. PMID: 6824640.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    262. Physiogenic bias as invalidity in psychiatric symptom scales. J Health Soc Behav. 1982 Sep; 23(3):235-52. Wells JA, Strickland DE. PMID: 7175160.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    263. Chemical modification of myosin by active-site trapping of metal-nucleotides with thiol crosslinking reagents. Methods Enzymol. 1982; 85 Pt B:93-116. Wells JA, Yount RG. PMID: 7121292.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    264. Cross-linking of myosin subfragment 1. Nucleotide-enhanced modification by a variety of bifunctional reagents. J Biol Chem. 1980 Dec 10; 255(23):11135-40. Wells JA, Knoeber C, Sheldon MC, Werber MM, Yount RG. PMID: 7440533.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    265. Mechanism of inactivation of myosin subfragment 1 by Co(III)phenATP. A reinvestigation. J Biol Chem. 1980 Aug 25; 255(16):7552-5. Wells JA, Werber MM, Yount RG. PMID: 6447149.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    266. Reaction of 5,5'-dithiobis(2-nitrobenzoic acid) with myosin subfragment one: evidence for formation of a single protein disulfide with trapping of metal nucleotide at the active site. Biochemistry. 1980 Apr 15; 19(8):1711-7. Wells JA, Yount RG. PMID: 6445748.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    267. Magnesium nucleotide is stoichiometrically trapped at the active site of myosin and its active proteolytic fragments by thiol cross-linking reagents. J Biol Chem. 1980 Feb 25; 255(4):1598-602. Wells JA, Sheldon M, Yount RG. PMID: 6444414.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    268. "Reaction of 5,5'-dithiobis (2-nitrobenzoic acid) with myosin subfragment one: Evidence for formation of a single protein disulfide with trapping of metal nucleotide at the active site". Biochemistry. 1980; 19:1711-1717. Wells, J.A. and Yount, R.G.
    269. "Magnesium nucleotide is stoichiometrically trapped at the active site of myosin and its proteolytic subfragments by thiol cross-linking reagents". J. Biol. Chem. 1980; 255:1598-1602. Wells, J.A., Sheldon, M., and Yount, R.G.
    270. Inactivation of myosin subfragment one by cobalt(II)/cobalt(III) phenanthroline complexes. I. Incorporation of Co(III) by in situ oxidation of Co(II). Biochemistry. 1979 Oct 30; 18(22):4793-9. Wells JA, Werber MM, Legg JI, Yount RG. PMID: 41570.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    271. Inactivation of myosin subfragment one by cobalt(II)/cobalt(III) phenanthroline complexes. 2. Cobalt chelation of two critical SH groups. Biochemistry. 1979 Oct 30; 18(22):4800-5. Wells JA, Werber MM, Yount RG. PMID: 159719.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    272. Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin subfragment 1. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):4966-70. Wells JA, Yount RG. PMID: 159451.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    273. Occupational stress and health among factory workers. J Health Soc Behav. 1979 Jun; 20(2):139-60. House JS, McMichael AJ, Wells JA, Kaplan BH, Landerman LR. PMID: 479526.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    274. "Inactivation of myosin subfragment one by cobalt (II)/cobalt (III) phenanthroline complexes. 1. Incorporation of Co(III) by in situ oxidation of Co(II)". Biochemistry. 1979; 18:4793-4799. . Wells, J.A., Werber, M.M. and Yount, R.G.
    275. "Active site trapping of nucleotides by crosslinking two sulfhydryls in myosin sub-fragment 1". Proc. Natl. Acad. Sci. USA. 1979; 76:4966-4970. Wells, J.A. and Yount, R.G.
    276. "Inactivation of myosin subfragment one by cobalt (II)/cobalt (III) phenanthroline complexes. 2. Cobalt chelation of two critical SH groups". Biochemistry. 1979; 18:4800-4805. Wells, J.A., Werber, M.M., Legg, J.I., and Yount, R.G.
    277. Do we need a burn severity grading system. J Trauma. 1977 Mar; 17(3):252-5. Fisher JC, Wells JA, Fulwider BT, Edgerton MT. PMID: 850285.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    278. Issues in specialty certification. ANA Publ. 1975; (PMH-2):6-14. Wells JA. PMID: 1045880.
      View in: PubMed   Mentions:    Fields:    
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