Yue Leng, PhD

Title(s)Assistant Professor, Psychiatry
SchoolSchool of Medicine
Address675 18th Street
San Francisco CA 94107
Phone415-221-4810 ext. 26565
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of Cambridge, Cambridge, UKPhD07/2015Epidemiology
    University of Cambridge, Cambridge, UKMPhil08/2011Epidemiology
    Sun Yat-Sen University School of Medicine, Guangzhou, ChinaBMed06/2010Preventive Medicine
    Collapse Awards and Honors
    National Institute on Aging2017  - 2022Pathway to Independence Award (K99/R00)
    Global Brain Health Institute2017  - 2018Atlantic Fellow
    University of Cambridge2011  - 2015Cambridge International Scholarship
    China Medical Board (New York)2010  - 2011Next Generation Fellowship

    Collapse Overview 
    Collapse Overview
    As an internationally-trained epidemiologist, Dr. Leng is interested in studying the link between sleep and neurodegeneration in older adults. Her research program, supported by an NIH K99/R00 award, focuses on the relationship between napping, sleep, circadian rhythms and risk of neurodegenerative diseases. Dr. Leng is also interested in developing behavioral sleep intervention programs in patients with mild cognitive impairment, with the ultimate goal of decreasing risk of Alzheimer’s onset or progression.

    Collapse Research 
    Collapse Research Activities and Funding
    Napping, Sleep, Cognitive Decline and Risk of Alzheimer's Disease
    NIH R00AG056598Aug 15, 2017 - Jan 31, 2023
    Role: Principal Investigator
    Napping, Sleep, Cognitive Decline and Risk of Alzheimer's Disease
    NIH K99AG056598Aug 15, 2017 - Feb 15, 2020
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cognitive and Functional Trajectories in Older Adults With Prediagnostic Parkinson Disease. Neurology. 2022 Dec 29. Bock MA, Vittinghoff E, Bahorik AL, Leng Y, Fink H, Yaffe K. PMID: 36581466.
      View in: PubMed   Mentions:
    2. Age differences in the association between sleep and Alzheimer's disease biomarkers in the EPAD cohort. Alzheimers Dement (Amst). 2022; 14(1):e12380. Naismith SL, Leng Y, Palmer JR, Lucey BP. PMID: 36447477; PMCID: PMC9695753.
      View in: PubMed   Mentions:
    3. Associations of 24-hour Light Exposure and Activity Patterns and Risk of Cognitive Impairment and Decline in Older Men: The MrOS Sleep Study. J Gerontol A Biol Sci Med Sci. 2022 Sep 26. Blackwell TL, Figueiro MG, Tranah GJ, Zeitzer JM, Yaffe K, Ancoli-Israel S, Kado DM, Ensrud KE, Lane NE, Leng Y, Stone KL, Osteoporotic Fractures in Men (MrOS) Study Group. PMID: 36156079.
      View in: PubMed   Mentions:
    4. Depression, Depression Treatments, and Risk of Incident Dementia: A Prospective Cohort Study of 354,313 Participants. Biol Psychiatry. 2022 Sep 05. Yang L, Deng YT, Leng Y, Ou YN, Li YZ, Chen SD, He XY, Wu BS, Huang SY, Zhang YR, Kuo K, Feng W, Dong Q, Feng JF, Suckling J, Smith AD, Li F, Cheng W, Yu JT. PMID: 36526487.
      View in: PubMed   Mentions:
    5. Editorial: Current Concept and Translational Study in ALS-FTD Spectrum: From Genetics, Neuroinflammation to Neurodegeneration. Front Mol Neurosci. 2022; 15:935115. Guo W, Zou ZY, Leng Y, Shen DD, Chen S. PMID: 35754709; PMCID: PMC9231587.
      View in: PubMed   Mentions:
    6. Daytime napping and Alzheimer's dementia: A potential bidirectional relationship. Alzheimers Dement. 2022 Mar 17. Li P, Gao L, Yu L, Zheng X, Ulsa MC, Yang HW, Gaba A, Yaffe K, Bennett DA, Buchman AS, Hu K, Leng Y. PMID: 35297533; PMCID: PMC9481741.
      View in: PubMed   Mentions: 1     Fields:    
    7. Public Willingness and Determinants of COVID-19 Vaccination at the Initial Stage of Mass Vaccination in China. Vaccines (Basel). 2021 Oct 13; 9(10). Zhao YM, Liu L, Sun J, Yan W, Yuan K, Zheng YB, Lu ZA, Liu L, Ni SY, Su SZ, Zhu XM, Zeng N, Gong YM, Wu P, Ran MS, Leng Y, Shi J, Shi L, Lu L, Bao YP. PMID: 34696281; PMCID: PMC8538840.
      View in: PubMed   Mentions: 9  
    8. Predicting incident dementia and mild cognitive impairment in older women with nonparametric analysis of circadian activity rhythms in the Study of Osteoporotic Fractures. Sleep. 2021 10 11; 44(10). Posner AB, Tranah GJ, Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Leng Y, Zeitzer JM, Chen DM, Webber KR, Stone KL. PMID: 33964167; PMCID: PMC8503832.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Peripheral Clock System Abnormalities in Patients With Parkinson's Disease. Front Aging Neurosci. 2021; 13:736026. Li T, Cheng C, Jia C, Leng Y, Qian J, Yu H, Liu Y, Wang N, Yang Y, Al-Nusaif M, Le W. PMID: 34658839; PMCID: PMC8519399.
      View in: PubMed   Mentions: 2  
    10. Current Alzheimer disease research highlights: evidence for novel risk factors. Chin Med J (Engl). 2021 Sep 09; 134(18):2150-2159. Brenowitz WD, Xiang Y, McEvoy CT, Yang C, Yaffe K, Le WD, Leng Y. PMID: 34507318; PMCID: PMC8478399.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Association between contact with a general practitioner and depressive symptoms during the COVID-19 pandemic and lockdown: a large community-based study in Hangzhou, China. BMJ Open. 2021 08 13; 11(8):e052383. Yang F, Lin W, Frost E, Min Y, Xu X, Wang X, Li W, Leng Y, Zhao X, He W, Hsing AW, Zhu S. PMID: 34389582; PMCID: PMC8366284.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    12. Sleep Timing and Risk of Dementia Among the Chinese Elderly in an Urban Community: The Shanghai Aging Study. Front Neurol. 2021; 12:629507. Li X, Ding D, Zhao Q, Wu W, Xiao Z, Luo J, Yaffe K, Leng Y. PMID: 33995242; PMCID: PMC8116668.
      View in: PubMed   Mentions:
    13. Grandparental care and sleep disturbances in preschool children: a population-based prospective cohort study. Sleep Med. 2021 06; 82:165-171. Li W, Wang G, Yu Z, Ip P, Leng Y, Zhang Y, Zhao J, Zhang J, Jiang Y, Deng Y, Wu Y, Meng M, Zhu Q, Jiang F. PMID: 33933721.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Traumatic Brain Injury and Incidence Risk of Sleep Disorders in Nearly 200,000 US Veterans. Neurology. 2021 03 30; 96(13):e1792-e1799. Leng Y, Byers AL, Barnes DE, Peltz CB, Li Y, Yaffe K. PMID: 33658328; PMCID: PMC8055309.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Pharmacological and non-pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review. J Sleep Res. 2021 08; 30(4):e13229. Blackman J, Swirski M, Clynes J, Harding S, Leng Y, Coulthard E. PMID: 33289311; PMCID: PMC8365694.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    16. Genetic Risk of Alzheimer's Disease and Sleep Duration in Non-Demented Elders. Ann Neurol. 2021 01; 89(1):177-181. Leng Y, Ackley SF, Glymour MM, Yaffe K, Brenowitz WD. PMID: 32951248; PMCID: PMC8048405.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. Association of Circadian Abnormalities in Older Adults With an Increased Risk of Developing Parkinson Disease. JAMA Neurol. 2020 10 01; 77(10):1270-1278. Leng Y, Blackwell T, Cawthon PM, Ancoli-Israel S, Stone KL, Yaffe K. PMID: 32539075; PMCID: PMC7296450.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    18. Sleep Duration and Cognitive Aging-Beyond a U-Shaped Association. JAMA Netw Open. 2020 09 01; 3(9):e2014008. Leng Y, Yaffe K. PMID: 32955568.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. Corrigendum to: Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study. Sleep. 2020 07 13; 43(7). Zitser J, Anatürk M, Zsoldos E, Mahmood A, Filippini N, Suri S, Leng Y, Yaffe K, Singh-Manoux A, Kivimaki M, Ebmeier K, Sexton C. PMID: 32191796; PMCID: PMC7355394.
      View in: PubMed   Mentions:    Fields:    
    20. Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study. Sleep. 2020 05 12; 43(5). Zitser J, Anatürk M, Zsoldos E, Mahmood A, Filippini N, Suri S, Leng Y, Yaffe K, Singh-Manoux A, Kivimaki M, Ebmeier K, Sexton C. PMID: 31904084; PMCID: PMC7215267.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    21. Multidimensional Sleep and Mortality in Older Adults: A Machine-Learning Comparison With Other Risk Factors. J Gerontol A Biol Sci Med Sci. 2019 11 13; 74(12):1903-1909. Wallace ML, Buysse DJ, Redline S, Stone KL, Ensrud K, Leng Y, Ancoli-Israel S, Hall MH. PMID: 30778527; PMCID: PMC6853700.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    22. To nap or not to nap: more questions than answers. Heart. 2019 12; 105(23):1768-1769. Leng Y, Yaffe K. PMID: 31501229.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Association between earthquake experience and depression 37 years after the Tangshan earthquake: a cross-sectional study. BMJ Open. 2019 08 20; 9(8):e026110. Gao X, Leng Y, Guo Y, Yang J, Cui Q, Geng B, Hu H, Zhou Y. PMID: 31434762; PMCID: PMC6707697.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. Cross-cultural disparities of subjective sleep parameters and their age-related trends over the first three years of human life: A systematic review and meta-analysis. Sleep Med Rev. 2019 12; 48:101203. Lin QM, Spruyt K, Leng Y, Jiang YR, Wang GH, Dong SM, Mei H, Jiang F. PMID: 31494051.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Connections Between Insomnia and Cognitive Aging. Neurosci Bull. 2020 Jan; 36(1):77-84. Sexton CE, Sykara K, Karageorgiou E, Zitser J, Rosa T, Yaffe K, Leng Y. PMID: 31222500; PMCID: PMC6940406.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    26. Objective napping, cognitive decline, and risk of cognitive impairment in older men. Alzheimers Dement. 2019 08; 15(8):1039-1047. Leng Y, Redline S, Stone KL, Ancoli-Israel S, Yaffe K. PMID: 31227429; PMCID: PMC6699896.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    27. Interventions involving a major dietary component improve cognitive function in cognitively healthy adults: a systematic review and meta-analysis. Nutr Res. 2019 06; 66:1-12. McEvoy CT, Leng Y, Peeters GM, Kaup AR, Allen IE, Yaffe K. PMID: 31022563.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    28. Association between circadian rhythms and neurodegenerative diseases. Lancet Neurol. 2019 03; 18(3):307-318. Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K. PMID: 30784558; PMCID: PMC6426656.
      View in: PubMed   Mentions: 113     Fields:    Translation:Humans
    29. Gender differences in the relationship between alcohol consumption and insomnia in the northern Chinese population. PLoS One. 2018; 13(12):e0207392. Guo Y, Hu H, Liu Y, Leng Y, Gao X, Cui Q, Chen J, Geng B, Zhou Y. PMID: 30521547; PMCID: PMC6283629.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Mortality risk of loneliness in the oldest old over a 10-year follow-up. Aging Ment Health. 2020 01; 24(1):35-40. Wang H, Leng Y, Zhao E, Fleming J, Brayne C, CC75C Study Collaboration. PMID: 30450926.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Excessive daytime sleepiness, objective napping and 11-year risk of Parkinson's disease in older men. Int J Epidemiol. 2018 10 01; 47(5):1679-1686. Leng Y, Goldman SM, Cawthon PM, Stone KL, Ancoli-Israel S, Yaffe K. PMID: 29873737; PMCID: PMC6208269.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    32. Antidepressant Use and Cognitive Outcomes in Very Old Women. J Gerontol A Biol Sci Med Sci. 2018 09 11; 73(10):1390-1395. Leng Y, Diem SJ, Stone KL, Yaffe K. PMID: 29244058; PMCID: PMC6132122.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    33. Intracranial Aneurysm Wall Enhancement Associated with Aneurysm Rupture: A Systematic Review and Meta-analysis. Acad Radiol. 2019 05; 26(5):664-673. Wang X, Zhu C, Leng Y, Degnan AJ, Lu J. PMID: 29908979.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    34. Corrigendum to: "Who Take Naps? Self-Reported and Objectively Measured Napping in Very Old Women". J Gerontol A Biol Sci Med Sci. 2018 03 02; 73(3):419. Leng Y, Stone K, Ancoli-Israel S, Covinsky K, Yaffe K. PMID: 29155930; PMCID: PMC5861936.
      View in: PubMed   Mentions: 1     Fields:    
    35. Who Take Naps? Self-Reported and Objectively Measured Napping in Very Old Women. J Gerontol A Biol Sci Med Sci. 2018 03 02; 73(3):374-379. Leng Y, Stone K, Ancoli-Israel S, Covinsky K, Yaffe K. PMID: 28329031; PMCID: PMC5861957.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    36. Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review and Meta-analysis. JAMA Neurol. 2017 10 01; 74(10):1237-1245. Leng Y, McEvoy CT, Allen IE, Yaffe K. PMID: 28846764; PMCID: PMC5710301.
      View in: PubMed   Mentions: 90     Fields:    Translation:Humans
    37. How are age-related differences in sleep quality associated with health outcomes? An epidemiological investigation in a UK cohort of 2406 adults. BMJ Open. 2017 Jul 31; 7(7):e014920. Gadie A, Shafto M, Leng Y, Kievit RA, Cam-CAN . PMID: 28760786; PMCID: PMC5642766.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    38. Periodic Limb Movements in Sleep are Associated with Greater Cognitive Decline in Older Men without Dementia. Sleep. 2016 Oct 01; 39(10):1807-1810. Leng Y, Blackwell T, Stone KL, Hoang TD, Redline S, Yaffe K. PMID: 27568800; PMCID: PMC5020362.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    39. A population study of the association between sleep disturbance and suicidal behaviour in people with mental illness. J Psychiatr Res. 2016 11; 82:149-54. Stubbs B, Wu YT, Prina AM, Leng Y, Cosco TD. PMID: 27501141.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    40. Daytime napping and increased risk of incident respiratory diseases: symptom, marker, or risk factor? Sleep Med. 2016 07; 23:12-15. Leng Y, Wainwright NW, Cappuccio FP, Surtees PG, Hayat S, Luben R, Brayne C, Khaw KT. PMID: 27692271; PMCID: PMC5066369.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    41. Daytime napping, sleep duration and increased 8-year risk of type 2 diabetes in a British population. Nutr Metab Cardiovasc Dis. 2016 11; 26(11):996-1003. Leng Y, Cappuccio FP, Surtees PG, Luben R, Brayne C, Khaw KT. PMID: 27484757; PMCID: PMC5084679.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    42. Sleep duration and risk of fatal and nonfatal stroke: a prospective study and meta-analysis. Neurology. 2015 Mar 17; 84(11):1072-9. Leng Y, Cappuccio FP, Wainwright NW, Surtees PG, Luben R, Brayne C, Khaw KT. PMID: 25716357; PMCID: PMC4371404.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    43. Daytime napping, sleep duration and serum C reactive protein: a population-based cohort study. BMJ Open. 2014 Nov 11; 4(11):e006071. Leng Y, Ahmadi-Abhari S, Wainwright NW, Cappuccio FP, Surtees PG, Luben R, Brayne C, Khaw KT. PMID: 25387759; PMCID: PMC4244397.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    44. Daytime napping and the risk of all-cause and cause-specific mortality: a 13-year follow-up of a British population. Am J Epidemiol. 2014 May 01; 179(9):1115-24. Leng Y, Wainwright NW, Cappuccio FP, Surtees PG, Hayat S, Luben R, Brayne C, Khaw KT. PMID: 24685532; PMCID: PMC3992821.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    45. Self-reported sleep patterns in a British population cohort. Sleep Med. 2014 Mar; 15(3):295-302. Leng Y, Wainwright NW, Cappuccio FP, Surtees PG, Luben R, Wareham N, Brayne C, Khaw KT. PMID: 24503473; PMCID: PMC3988958.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    46. Epidemiology of esophageal cancer in Yanting - regional report of a national screening programme in China. Asian Pac J Cancer Prev. 2013; 14(4):2429-32. Wang X, Fan JC, Wang AR, Leng Y, Li J, Bao Y, Wang Y, Yang QF, Ren Y. PMID: 23725152.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    47. The association between social stress and global cognitive function in a population-based study: the European Prospective Investigation into Cancer (EPIC)-Norfolk study. Psychol Med. 2013 Mar; 43(3):655-66. Leng Y, Wainwright NW, Hayat S, Stephan BC, Matthews FE, Luben R, Surtees PG, Khaw KT, Brayne C. PMID: 22687394.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    48. Cervical cancer in Indigenous women: The case of Australia. Maturitas. 2011 Nov; 70(3):234-45. Shannon GD, Franco OH, Powles J, Leng Y, Pashayan N. PMID: 21889857.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
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