Willa Brenowitz, PhD, MPH
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Title(s) | Assistant Professor, Epidemiology & Biostatistics |
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School | School of Medicine |
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Address | 675 18th Street, #5132 San Francisco CA 94107
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vCard | Download vCard |
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Biography
Cornell University | BA | | Biology and Society |
University of Washington | MPH | | Health Services |
University of Washington | PhD | | Epidemiology |
University of California, San Francisco | Postdoctoral | | Epidemiology of Aging/Chronic Disease |
University of California, San Francisco | | | Diversity, Equity, and Inclusion Champion Training |
Overview
I am an epidemiologist and I am broadly interested in understanding factors that contribute to brain aging. I am especially interested in the role of multimorbidity in cognitive decline, as well as the intersection of genetic, psychosocial, and health factors across the lifecourse. I am also interested in using novel statistical and epidemiologic approaches to study AD and other chronic diseases in aging.
Much of my current research focuses on the relationship between sensory impairments (e.g. hearing and vision loss) and dementia in older adults. I am also interested in quasi experimental designs and instrumental variable analysis including Mendelian randomization. Such alternative study design offer opportunities to better understand early AD etiology and tease apart mechanisms that may contribute or be a marker of AD and brain aging.
My primary institution is Kaiser Permanente Center for Health Research, and I am a UCSF affiliate. I welcome student involvement, please feel free to contact me to discuss further.
Research
Bibliographic
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Snoring and risk of dementia: a prospective cohort and Mendelian randomization study. Sleep. 2025 Jan 13; 48(1).
Gao Y, Andrews S, Daghlas I, Brenowitz WD, Raji CA, Yaffe K, Leng Y. PMID: 38943476; PMCID: PMC11725511.
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LONGITUDINAL ASSOCIATIONS OF HEARING IMPAIRMENT WITH SOCIAL ISOLATION AMONG BLACK AND WHITE OLDER ADULTS. Innovation in Aging. 2024 Dec 31; 8(Supplement_1):1256-1256.
Thoma TM, Ferguson FE, Torres TJ, Armstrong AN, Yaffe YK, Brenowitz BW. .
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The relationship between APOE genotype and dementia varies by genetic ancestry and race/ethnicity. Alzheimer's & Dementia. 2024 Dec 1; 20(Suppl 7):e093068.
Gilmore GM, Varga VA, Schaefer SC, Banda BY, Hoffmann HT, Glymour GM, Weinmann WS, Choquet CH, Smith SN, Gilsanz GP, Massimino MS, Brenowitz BW. .
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Dementia risk scores, apolipoprotein E, and risk of Alzheimer's disease: One size does not fit all. Alzheimers Dement. 2024 Dec; 20(12):8595-8604.
Andrews SJ, Boeriu AI, Belloy ME, Renton AE, Fulton-Howard B, Brenowitz WD, Yaffe K, Alzheimer's Disease Neuroimaging Initiative. PMID: 39428957; PMCID: PMC11667490.
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1 Fields:
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Humans
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State Schooling Policies and Cognitive Performance Trajectories: A Natural Experiment in a National US Cohort of Black and White Adults. Epidemiology. 2025 Jan 01; 36(1):79-87.
Kim MH, Liu SY, Brenowitz WD, Murchland AR, Nguyen TT, Manly JJ, Howard VJ, Thomas MD, Hill-Jarrett T, Crowe M, Murchison CF, Glymour MM. PMID: 39329415; PMCID: PMC11598670.
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Dementia Risk Scores, APOE, and risk of Alzheimer disease: one size does not fit all. medRxiv. 2024 Aug 16.
Andrews SJ, Boeriu AI, Belloy ME, Renton AE, Fulton-Howard B, Brenowitz WD, Yaffe K, Alzheimer’s Disease Neuroimaging Initiative. PMID: 38746455; PMCID: PMC11092714.
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Visual Impairment, Eye Conditions, and Diagnoses of Neurodegeneration and Dementia. JAMA Netw Open. 2024 Jul 01; 7(7):e2424539.
Ferguson EL, Thoma M, Buto PT, Wang J, Glymour MM, Hoffmann TJ, Choquet H, Andrews SJ, Yaffe K, Casaletto K, Brenowitz WD. PMID: 39078629; PMCID: PMC11289698.
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Genetic risk score for Alzheimer's disease predicts brain volume differences in mid and late life in UK biobank participants. Alzheimers Dement. 2024 03; 20(3):1978-1987.
Buto PT, Wang J, La Joie R, Zimmerman SC, Glymour MM, Ackley SF, Hoffmann TJ, Yaffe K, Zeki Al Hazzouri A, Brenowitz WD. PMID: 38183377; PMCID: PMC10984491.
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1 Fields:
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Humans
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Olfactory Dysfunction and Depression Trajectories in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2024 01 01; 79(1).
Kamath V, Jiang K, Manning KJ, Mackin RS, Walker KA, Powell D, Lin FR, Chen H, Brenowitz WD, Yaffe K, Simonsick EM, Deal JA. PMID: 37357824; PMCID: PMC10733184.
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3 Fields:
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Humans
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ASSOCIATIONS OF VISUAL IMPAIRMENTS AND OCULAR DISEASE WITH BRAIN VOLUMES AND DEMENTIA IN UK BIOBANK. Innovation in Aging. 2023 Dec 21; 7(Suppl 1):192-193.
Ferguson FE, Buto BP, Thoma TJ, Casaletto CS, Choquet CT, Yaffe YK, Glymour GM, Brenowitz BW. .
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Food Insecurity, Memory, and Dementia Among US Adults Aged 50 Years and Older. JAMA Netw Open. 2023 11 01; 6(11):e2344186.
Qian H, Khadka A, Martinez SM, Singh S, Brenowitz WD, Zeki Al Hazzouri A, Hill-Jarrett TG, Glymour MM, Vable AM. PMID: 37988079; PMCID: PMC10663972.
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5 Fields:
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Humans
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Snoring and risk of dementia: a prospective cohort and Mendelian randomization study. medRxiv. 2023 Oct 13.
Gao Y, Andrews S, Brenowitz W, Raji CA, Yaffe K, Leng Y. PMID: 37873444; PMCID: PMC10593011.
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Education, incident cancer, and rate of memory decline in a national sample of US adults in mid-to-later-life. J Geriatr Oncol. 2023 06; 14(5):101530.
Ospina-Romero M, Brenowitz WD, Glymour MM, Westrick A, Graff RE, Hayes-Larson E, Mayeda ER, Ackley SF, Kobayashi LC. PMID: 37210786; PMCID: PMC10332197.
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Alzheimer's Disease Genetic Risk, Cognition, and Brain Aging in Midlife. Ann Neurol. 2023 03; 93(3):629-634.
Brenowitz WD, Fornage M, Launer LJ, Habes M, Davatzikos C, Yaffe K. PMID: 36511390; PMCID: PMC9974745.
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1 Fields:
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Observational studies in Alzheimer disease: bridging preclinical studies and clinical trials. Nat Rev Neurol. 2022 12; 18(12):747-757.
Brenowitz WD, Yaffe K. PMID: 36316487; PMCID: PMC9894623.
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3 Fields:
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Associations of dual sensory impairment with long-term depressive and anxiety symptoms in the United States. J Affect Disord. 2022 11 15; 317:114-122.
Armstrong NM, Vieira Ligo Teixeira C, Gendron C, Brenowitz WD, Lin FR, Swenor B, Powell DS, Deal JA, Simonsick EM, Jones RN. PMID: 35932940; PMCID: PMC10696594.
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2 Fields:
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Associations Between Handgrip Strength and Dementia Risk, Cognition, and Neuroimaging Outcomes in the UK Biobank Cohort Study. JAMA Netw Open. 2022 06 01; 5(6):e2218314.
Duchowny KA, Ackley SF, Brenowitz WD, Wang J, Zimmerman SC, Caunca MR, Glymour MM. PMID: 35737388; PMCID: PMC9227006.
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35 Fields:
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Examining the Combined Estimated Effects of Hearing Loss and Depressive Symptoms on Risk of Cognitive Decline and Incident Dementia. J Gerontol B Psychol Sci Soc Sci. 2022 05 05; 77(5):839-849.
Powell DS, Brenowitz WD, Yaffe K, Armstrong NM, Reed NS, Lin FR, Gross AL, Deal JA. PMID: 34655295; PMCID: PMC9071460.
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10 Fields:
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Humans
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Association of Genetic Variants Linked to Late-Onset Alzheimer Disease With Cognitive Test Performance by Midlife. JAMA Netw Open. 2022 04 01; 5(4):e225491.
Zimmerman SC, Brenowitz WD, Calmasini C, Ackley SF, Graff RE, Asiimwe SB, Staffaroni AM, Hoffmann TJ, Glymour MM. PMID: 35377426; PMCID: PMC8980909.
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10 Fields:
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Associations of dual sensory impairment with incident mobility and ADL difficulty. J Am Geriatr Soc. 2022 07; 70(7):1997-2007.
Armstrong NM, Vieira Ligo Teixeira C, Gendron C, Brenowitz WD, Lin FR, Swenor B, Deal JA, Simonsick EM, Jones RN. PMID: 35343588; PMCID: PMC9283239.
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8 Fields:
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Associations of Lower Extremity Peripheral Nerve Impairment and Risk of Dementia in Black and White Older Adults. Neurology. 2022 05 03; 98(18):e1837-e1845.
Brenowitz WD, Robbins NM, Strotmeyer ES, Yaffe K. PMID: 35264428; PMCID: PMC9109146.
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6 Fields:
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Invited Commentary: Body Mass Index and Risk of Dementia-Potential Explanations for Life-Course Differences in Risk Estimates and Future Research Directions. Am J Epidemiol. 2021 12 01; 190(12):2511-2514.
Brenowitz WD. PMID: 33831175; PMCID: PMC8796800.
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2 Fields:
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Assessing bidirectional associations between cognitive impairment and late age-related macular degeneration in the Age-Related Eye Disease Study 2. Alzheimers Dement. 2022 07; 18(7):1296-1305.
Le JT, Agrón E, Keenan TDL, Clemons TE, Brenowitz WD, Yaffe K, Chew EY, AREDS2 Research Group. PMID: 34758100; PMCID: PMC9085971.
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4 Fields:
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Extension of Mendelian Randomization to Identify Earliest Manifestations of Alzheimer Disease: Association of Genetic Risk Score for Alzheimer Disease With Lower Body Mass Index by Age 50 Years. Am J Epidemiol. 2021 10 01; 190(10):2163-2171.
Brenowitz WD, Zimmerman SC, Filshtein TJ, Yaffe K, Walter S, Hoffmann TJ, Jorgenson E, Whitmer RA, Whitmer RA, Glymour MM. PMID: 33843952; PMCID: PMC8576370.
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11 Fields:
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Current Alzheimer disease research highlights: evidence for novel risk factors. Chin Med J (Engl). 2021 Sep 09; 134(18):2150-2159.
Brenowitz WD, Xiang Y, McEvoy CT, Yang C, Yaffe K, Le WD, Leng Y. PMID: 34507318; PMCID: PMC8478399.
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12 Fields:
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The Association Between Cancer and Spousal Rate of Memory Decline: A Negative Control Study to Evaluate (Unmeasured) Social Confounding of the Cancer-memory Relationship. Alzheimer Dis Assoc Disord. 2021 Jul-Sep 01; 35(3):271-274.
Ospina-Romero M, Brenowitz WD, Glymour MM, Mayeda ER, Graff RE, Witte JS, Ackley SF, Lu KP, Kobayashi LC. PMID: 32568784; PMCID: PMC7749066.
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2 Fields:
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Humans
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Methods to Address Self-Selection and Reverse Causation in Studies of Neighborhood Environments and Brain Health. Int J Environ Res Public Health. 2021 06 16; 18(12).
Besser LM, Brenowitz WD, Meyer OL, Hoermann S, Renne J. PMID: 34208454; PMCID: PMC8296350.
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17 Fields:
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Amyloid-PET imaging offers small improvements in predictions of future cognitive trajectories. Neuroimage Clin. 2021; 31:102713.
Ackley SF, Hayes-Larson E, Brenowitz WD, Swinnerton K, Mungas D, Fletcher E, Singh B, Whitmer RA, Whitmer RA, DeCarli C, Maria Glymour M. PMID: 34153689; PMCID: PMC8233225.
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2 Fields:
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Does Hearing Impairment Affect Physical Function?: Current Evidence, Potential Mechanisms, and Future Research Directions for Healthy Aging. JAMA Netw Open. 2021 06 01; 4(6):e2114782.
Brenowitz WD, Wallhagen MI. PMID: 34170308.
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4 Fields:
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Humans
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The Bidirectional Relationship between Vision and Cognition: A Systematic Review and Meta-analysis. Ophthalmology. 2021 07; 128(7):981-992.
Vu TA, Fenwick EK, Gan ATL, Man REK, Tan BKJ, Gupta P, Ho KC, Reyes-Ortiz CA, Trompet S, Gussekloo J, O'Brien JM, Mueller-Schotte S, Wong TY, Tham YC, Cheng CY, Lee ATC, Rait G, Swenor BK, Varadaraj V, Brenowitz WD, Medeiros FA, Naël V, Narasimhalu K, Chen CLH, Lamoureux EL. PMID: 33333104.
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29 Fields:
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Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis. BMJ. 2021 02 25; 372:n156.
Ackley SF, Zimmerman SC, Brenowitz WD, Tchetgen Tchetgen EJ, Gold AL, Manly JJ, Mayeda ER, Filshtein TJ, Power MC, Elahi FM, Brickman AM, Glymour MM. PMID: 33632704; PMCID: PMC7905687.
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67 Fields:
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Humans
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Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline. J Alzheimers Dis. 2021; 83(3):1379-1389.
Brenowitz WD, Zeki Al Hazzouri A, Vittinghoff E, Golden SH, Fitzpatrick AL, Yaffe K. PMID: 34420969; PMCID: PMC9095065.
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9 Fields:
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Humans
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Association Between Alzheimer Disease and Cancer With Evaluation of Study Biases: A Systematic Review and Meta-analysis. JAMA Netw Open. 2020 11 02; 3(11):e2025515.
Ospina-Romero M, Glymour MM, Hayes-Larson E, Mayeda ER, Graff RE, Brenowitz WD, Ackley SF, Witte JS, Kobayashi LC. PMID: 33185677; PMCID: PMC7666424.
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50 Fields:
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Humans
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Apathy and risk of probable incident dementia among community-dwelling older adults. Neurology. 2020 12 15; 95(24):e3280-e3287.
Bock MA, Bahorik A, Brenowitz WD, Yaffe K. PMID: 33055276; PMCID: PMC7836653.
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13 Fields:
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Humans
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Genetic Risk of Alzheimer's Disease and Sleep Duration in Non-Demented Elders. Ann Neurol. 2021 01; 89(1):177-181.
Leng Y, Ackley SF, Glymour MM, Yaffe K, Brenowitz WD. PMID: 32951248; PMCID: PMC8048405.
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21 Fields:
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Humans
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16 Fields:
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Clinician-judged hearing impairment and associations with neuropathologic burden. Neurology. 2020 09 22; 95(12):e1640-e1649.
Brenowitz WD, Besser LM, Kukull WA, Keene CD, Glymour MM, Yaffe K. PMID: 32759190; PMCID: PMC7713726.
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8 Fields:
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HumansCells
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Incident dementia and faster rates of cognitive decline are associated with worse multisensory function summary scores. Alzheimers Dement. 2020 10; 16(10):1384-1392.
Brenowitz WD, Kaup AR, Yaffe K. PMID: 32657033; PMCID: PMC7901640.
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8 Fields:
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Humans
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Dual sensory impairment in older adults and risk of dementia from the GEM Study. Alzheimers Dement (Amst). 2020; 12(1):e12054.
Hwang PH, Longstreth WT, Brenowitz WD, Thielke SM, Lopez OL, Francis CE, DeKosky ST, Fitzpatrick AL. PMID: 32671180; PMCID: PMC7340796.
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21 Fields:
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State School Policies as Predictors of Physical and Mental Health: A Natural Experiment in the REGARDS Cohort. Am J Epidemiol. 2020 05 05; 189(5):384-393.
Brenowitz WD, Manly JJ, Murchland AR, Nguyen TT, Liu SY, Glymour MM, Levine DA, Crowe M, Hohman TJ, Dufouil C, Launer LJ, Hedden T, Eng CW, Wadley VG, Howard VJ. PMID: 31595946; PMCID: PMC7306678.
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5 Fields:
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Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy. J Neuropathol Exp Neurol. 2020 05 01; 79(5):465-473.
Gauthreaux K, Bonnett TA, Besser LM, Brenowitz WD, Teylan M, Mock C, Chen YC, Chan KCG, Keene CD, Zhou XH, Kukull WA. PMID: 32186726; PMCID: PMC7160616.
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12 Fields:
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Intention to Screen for Alzheimer's Disease by Residential Locale. Int J Environ Res Public Health. 2020 03 27; 17(7).
Besser LM, Brenowitz WD, Park J, Tolea MI, Galvin JE. PMID: 32230914; PMCID: PMC7178144.
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1 Fields:
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HumansPHPublic Health
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Estimating associations between antidepressant use and incident mild cognitive impairment in older adults with depression. PLoS One. 2020; 15(1):e0227924.
Han F, Bonnett T, Brenowitz WD, Teylan MA, Besser LM, Chen YC, Chan G, Cao KG, Gao Y, Zhou XH. PMID: 31951629; PMCID: PMC6968868.
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2 Fields:
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Life course biopsychosocial effects of retrospective childhood social support and later-life cognition. Psychol Aging. 2019 Nov; 34(7):867-883.
Zahodne LB, Sharifian N, Manly JJ, Sumner JA, Crowe M, Wadley VG, Howard VJ, Murchland AR, Brenowitz WD, Weuve J. PMID: 31566397; PMCID: PMC6829036.
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7 Fields:
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Reserve and Alzheimer's disease genetic risk: Effects on hospitalization and mortality. Alzheimers Dement. 2019 07; 15(7):907-916.
Filshtein TJ, Brenowitz WD, Mayeda ER, Hohman TJ, Walter S, Jones RN, Elahi FM, Glymour MM. PMID: 31327391; PMCID: PMC7049165.
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8 Fields:
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Rate of Memory Change Before and After Cancer Diagnosis. JAMA Netw Open. 2019 06 05; 2(6):e196160.
Ospina-Romero M, Abdiwahab E, Kobayashi L, Filshtein T, Brenowitz WD, Mayeda ER, Glymour MM. PMID: 31225893; PMCID: PMC6593639.
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28 Fields:
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Multiple Sensory Impairment Is Associated With Increased Risk of Dementia Among Black and White Older Adults. J Gerontol A Biol Sci Med Sci. 2019 05 16; 74(6):890-896.
Brenowitz WD, Kaup AR, Lin FR, Yaffe K. PMID: 30452551; PMCID: PMC6521912.
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51 Fields:
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Treated hypothyroidism is associated with cerebrovascular disease but not Alzheimer's disease pathology in older adults. Neurobiol Aging. 2018 02; 62:64-71.
Brenowitz WD, Han F, Kukull WA, Nelson PT. PMID: 29107848; PMCID: PMC5743774.
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14 Fields:
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Mixed neuropathologies and associations with domain-specific cognitive decline. Neurology. 2017 Oct 24; 89(17):1773-1781.
Brenowitz WD, Hubbard RA, Keene CD, Hawes SE, Longstreth WT, Woltjer RL, Kukull WA. PMID: 28939667; PMCID: PMC5664309.
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15 Fields:
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Alzheimer's disease neuropathologic change, Lewy body disease, and vascular brain injury in clinic- and community-based samples. Neurobiol Aging. 2017 May; 53:83-92.
Brenowitz WD, Keene CD, Hawes SE, Hubbard RA, Longstreth WT, Woltjer RL, Crane PK, Larson EB, Kukull WA. PMID: 28236716; PMCID: PMC5385292.
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34 Fields:
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Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement. 2017 Jun; 13(6):654-662.
Brenowitz WD, Hubbard RA, Keene CD, Hawes SE, Longstreth WT, Woltjer RL, Kukull WA. PMID: 27870939; PMCID: PMC5438283.
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46 Fields:
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Cerebral amyloid angiopathy and its co-occurrence with Alzheimer's disease and other cerebrovascular neuropathologic changes. Neurobiol Aging. 2015 Oct; 36(10):2702-8.
Brenowitz WD, Nelson PT, Besser LM, Heller KB, Kukull WA. PMID: 26239176; PMCID: PMC4562901.
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62 Fields:
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Longitudinal associations between self-rated health and performance-based physical function in a population-based cohort of older adults. PLoS One. 2014; 9(11):e111761.
Brenowitz WD, Hubbard RA, Crane PK, Gray SL, Zaslavsky O, Larson EB. PMID: 25365288; PMCID: PMC4218810.
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21 Fields:
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HumansCTClinical Trials
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Social relationships and risk of incident mild cognitive impairment in U.S. Alzheimer's disease centers. Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):253-60.
Brenowitz WD, Kukull WA, Beresford SA, Monsell SE, Williams EC. PMID: 24577205; PMCID: PMC4139444.
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7 Fields:
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Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease. Alzheimer Dis Assoc Disord. 2014 Jan-Mar; 28(1):36-43.
Besser LM, Gill DP, Monsell SE, Brenowitz W, Meranus DH, Kukull W, Gustafson DR. PMID: 24126214; PMCID: PMC3945175.
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72 Fields:
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Hippocampal sclerosis of aging is a key Alzheimer's disease mimic: clinical-pathologic correlations and comparisons with both alzheimer's disease and non-tauopathic frontotemporal lobar degeneration. J Alzheimers Dis. 2014; 39(3):691-702.
Brenowitz WD, Monsell SE, Schmitt FA, Kukull WA, Nelson PT. PMID: 24270205; PMCID: PMC3946156.
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64 Fields:
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Arteriolosclerosis that affects multiple brain regions is linked to hippocampal sclerosis of ageing. Brain. 2014 Jan; 137(Pt 1):255-67.
Neltner JH, Abner EL, Baker S, Schmitt FA, Kryscio RJ, Jicha GA, Smith CD, Hammack E, Kukull WA, Brenowitz WD, Van Eldik LJ, Nelson PT. PMID: 24271328; PMCID: PMC3891448.
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78 Fields:
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This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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Year | Publications |
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2013 | 1 |
2014 | 4 |
2015 | 1 |
2016 | 1 |
2017 | 3 |
2019 | 4 |
2020 | 12 |
2021 | 11 |
2022 | 8 |
2023 | 4 |
2024 | 8 |
2025 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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