Shea Andrews, PhD

Title(s)Assistant Professor, Psychiatry
SchoolSchool of Medicine
Address675 18th Street, #5134
San Francisco CA 94107
ORCID ORCID Icon0000-0002-1921-947 Additional info
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    Australian National University, CanberraPhD2017Medical Sciences
    University of Queensland, BrisbaneBSc (Hons)2012Genetics
    University of Queensland, BrisbaneBA2010Journalism and Mass Communication, and Political Science

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    Dr. Andrews is a genetic epidemiologist looking at the role of genetic and environmental risk factors in Alzheimer's disease. The Andrews Lab focuses on determining the causal pathways that underly the development of Alzheimer’s disease and related dementias (ADRD) by applying statistical genetic and genetic epidemiological approaches to large genetic & phenotypic datasets. Currently funded NIH-NIA and Alzheimer’s Association projects include (1) identifying causal risk factors for ADRD using genetic correlations, polygenic risk scores, and mendelian randomization; (2) understanding the role of mitochondrial genomics in ADRD pathogenesis; and (3) evaluating ancestry specific effects of AD genetic variants on AD endophenotypes.
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    Ancestry-specific effects of APOE on AD endophenotypes and risk factors
    Alzheimer's Association ABA-22-969581Jul 15, 2022 - Jul 14, 2025
    Role: Principal Investigator
    Elucidating the causal associations underlying Alzheimer's disease
    NIH K99AG070109Feb 1, 2021 - Jan 31, 2023
    Role: Principal Investigator
    Assessing the causal role of mitochondria in Alzheimer’s disease
    Alzheimer's Association AARF-20-675804Jun 1, 2020 - May 1, 2023
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry. JAMA Neurol. 2023 Dec 01; 80(12):1284-1294. Belloy ME, Andrews SJ, Le Guen Y, Cuccaro M, Farrer LA, Napolioni V, Greicius MD. PMID: 37930705; PMCID: PMC10628838.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    2. Causal Associations of Sleep Apnea with Alzheimer's Disease and Cardiovascular Disease: a Bidirectional Mendelian Randomization Analysis. medRxiv. 2023 Nov 22. Cavaillès C, Andrews SJ, Leng Y, Chatterjee A, Daghlas I, Yaffe K. PMID: 38045267; PMCID: PMC10690337.
      View in: PubMed   Mentions:
    3. Snoring and risk of dementia: a prospective cohort and Mendelian randomization study. medRxiv. 2023 Oct 13. Gao Y, Andrews S, Brenowitz W, Raji CA, Yaffe K, Leng Y. PMID: 37873444; PMCID: PMC10593011.
      View in: PubMed   Mentions:
    4. Blood-Based Transcriptomic Biomarkers Are Predictive of Neurodegeneration Rather Than Alzheimer's Disease. Int J Mol Sci. 2023 Oct 09; 24(19). Shvetcov A, Thomson S, Spathos J, Cho AN, Wilkins HM, Andrews SJ, Delerue F, Couttas TA, Issar JK, Isik F, Kaur S, Drummond E, Dobson-Stone C, Duffy SL, Rogers NM, Catchpoole D, Gold WA, Swerdlow RH, Brown DA, Finney CA. PMID: 37834458; PMCID: PMC10573468.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Shared genetic risk loci between Alzheimer's disease and related dementias, Parkinson's disease, and amyotrophic lateral sclerosis. Alzheimers Res Ther. 2023 06 16; 15(1):113. Wainberg M, Andrews SJ, Tripathy SJ. PMID: 37328865; PMCID: PMC10273745.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    6. Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred. Alzheimers Dement. 2023 09; 19(9):3835-3847. Cochran JN, Acosta-Uribe J, Esposito BT, Madrigal L, Aguillón D, Giraldo MM, Taylor JW, Bradley J, Fulton-Howard B, Andrews SJ, Acosta-Baena N, Alzate D, Garcia GP, Piedrahita F, Lopez HE, Anderson AG, Rodriguez-Nunez I, Roberts K, Absher D, Myers RM, Beecham GW, Reitz C, Rizzardi LF, Fernandez MV, Goate AM, Cruchaga C, Renton AE, Lopera F, Kosik KS. PMID: 36951251; PMCID: PMC10514237.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. The complex genetic architecture of Alzheimer's disease: novel insights and future directions. EBioMedicine. 2023 Apr; 90:104511. Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM. PMID: 36907103; PMCID: PMC10024184.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    8. Microglial efferocytosis: Diving into the Alzheimer's disease gene pool. Neuron. 2022 11 02; 110(21):3513-3533. Romero-Molina C, Garretti F, Andrews SJ, Marcora E, Goate AM. PMID: 36327897.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    9. The role of mitochondrial genome abundance in Alzheimer's disease. Alzheimers Dement. 2023 05; 19(5):2069-2083. Harerimana NV, Paliwali D, Romero-Molina C, Bennett DA, Pa J, Goate A, Swerdlow RH, Andrews SJ. PMID: 36224040.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease. Brain. 2022 07 29; 145(7):2541-2554. Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi SE, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski CC, Hernandez Saucedo H, Widaman KF, Buckley RF, Properzi MJ, Mormino EC, Yang HS, Harrison TM, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Zhong X, Raghavan NS, Vardarajan BN, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team, Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg GD, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Cuccaro ML, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ. PMID: 35552371; PMCID: PMC9337804.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    11. A Mitochondrial DNA Haplogroup Defines Patterns of Five-Year Cognitive Change. J Alzheimers Dis. 2022; 89(3):913-922. Watts A, Chalise P, Hu J, Hui D, Pa J, Andrews SJ, Michaelis EK, Swerdlow RH. PMID: 35964186; PMCID: PMC10015634.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    12. Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease. Alzheimers Dement. 2022 06; 18(6):1260-1278. Horgusluoglu E, Neff R, Song WM, Wang M, Wang Q, Arnold M, Krumsiek J, Galindo-Prieto B, Ming C, Nho K, Kastenmüller G, Han X, Baillie R, Zeng Q, Andrews S, Cheng H, Hao K, Goate A, Bennett DA, Saykin AJ, Kaddurah-Daouk R, Zhang B, Alzheimer's Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Metabolomics Consortium. PMID: 34757660; PMCID: PMC9085975.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    13. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 2022 01; 143(1):33-53. Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF. PMID: 34719765; PMCID: PMC8786260.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    14. A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants. BMC Bioinformatics. 2021 Sep 01; 22(1):417. McInerney TW, Fulton-Howard B, Patterson C, Paliwal D, Jermiin LS, Patel HR, Pa J, Swerdlow RH, Goate A, Easteal S, Andrews SJ, for the Alzheimer’s Disease Neuroimaging Initiative. PMID: 34470617; PMCID: PMC8409003.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    15. Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease. Neurobiol Aging. 2021 12; 108:213-222. Paliwal D, McInerney TW, Pa J, Swerdlow RH, Easteal S, Andrews SJ, Alzheimer's Disease Neuroimaging Initiative. PMID: 34521561.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. Mapping the human genetic architecture of COVID-19. Nature. 2021 Dec; 600(7889):472-477. COVID-19 Host Genetics Initiative. PMID: 34237774; PMCID: PMC8674144.
      View in: PubMed   Mentions: 363     Fields:    Translation:HumansCells
    17. Beyond association: successes and challenges in linking non-coding genetic variation to functional consequences that modulate Alzheimer's disease risk. Mol Neurodegener. 2021 04 21; 16(1):27. Novikova G, Andrews SJ, Renton AE, Marcora E. PMID: 33882988; PMCID: PMC8061035.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    18. Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity. EBioMedicine. 2021 Mar; 65:103277. Fadista J, Kraven LM, Karjalainen J, Andrews SJ, Geller F, COVID-19 Host Genetics Initiative, Baillie JK, Wain LV, Jenkins RG, Feenstra B. PMID: 33714028; PMCID: PMC7946355.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    19. The variant call format provides efficient and robust storage of GWAS summary statistics. Genome Biol. 2021 01 13; 22(1):32. Lyon MS, Andrews SJ, Elsworth B, Gaunt TR, Hemani G, Marcora E. PMID: 33441155; PMCID: PMC7805039.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    20. Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome. Ann Neurol. 2021 01; 89(1):54-65. Andrews SJ, Fulton-Howard B, O'Reilly P, Marcora E, Goate AM, collaborators of the Alzheimer's Disease Genetics Consortium. PMID: 32996171; PMCID: PMC8088901.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    21. Genetic variants and functional pathways associated with resilience to Alzheimer's disease. Brain. 2020 08 01; 143(8):2561-2575. Dumitrescu L, Mahoney ER, Mukherjee S, Lee ML, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski C, Hernandez Saucedo H, Widaman KF, Buckley R, Properzi M, Mormino E, Yang HS, Harrison T, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Moore AM, Cambronero F, Zhong X, Raghavan NS, Vardarajan B, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team, Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg G, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ. PMID: 32844198; PMCID: PMC7447518.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    22. Exploratory analysis of mtDNA haplogroups in two Alzheimer's longitudinal cohorts. Alzheimers Dement. 2020 08; 16(8):1164-1172. Swerdlow RH, Hui D, Chalise P, Sharma P, Wang X, Andrews SJ, Pa J, Mahnken JD, Morris J, Wilkins HM, Burns JM, Michaelis ML, Michaelis EK, Alzheimer's Disease Neuroimaging Initiative (ADNI). PMID: 32543785; PMCID: PMC9847473.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    23. Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan. BJPsych Open. 2020 May 08; 6(3):e47. Burns RA, Andrews S, Cherbuin N, Anstey KJ. PMID: 32381152; PMCID: PMC7331079.
      View in: PubMed   Mentions: 4  
    24. Interpretation of risk loci from genome-wide association studies of Alzheimer's disease. Lancet Neurol. 2020 04; 19(4):326-335. Andrews SJ, Fulton-Howard B, Goate A. PMID: 31986256; PMCID: PMC8176461.
      View in: PubMed   Mentions: 134     Fields:    Translation:Humans
    25. Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study. Alzheimers Dement. 2020 02; 16(2):345-353. Andrews SJ, Goate A, Anstey KJ. PMID: 31786126; PMCID: PMC7057166.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    26. Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis. Neurology. 2020 01 21; 94(3):e267-e281. Peters R, Yasar S, Anderson CS, Andrews S, Antikainen R, Arima H, Beckett N, Beer JC, Bertens AS, Booth A, van Boxtel M, Brayne C, Brodaty H, Carlson MC, Chalmers J, Corrada M, DeKosky S, Derby C, Dixon RA, Forette F, Ganguli M, van Gool WA, Guaita A, Hever AM, Hogan DB, Jagger C, Katz M, Kawas C, Kehoe PG, Keinanen-Kiukaanniemi S, Kenny RA, Köhler S, Kunutsor SK, Laukkanen J, Maxwell C, McFall GP, van Middelaar T, Moll van Charante EP, Ng TP, Peters J, Rawtaer I, Richard E, Rockwood K, Rydén L, Sachdev PS, Skoog I, Skoog J, Staessen JA, Stephan BCM, Sebert S, Thijs L, Trompet S, Tully PJ, Tzourio C, Vaccaro R, Vaaramo E, Walsh E, Warwick J, Anstey KJ. PMID: 31827004; PMCID: PMC7108807.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    27. Mitonuclear interactions influence Alzheimer's disease risk. Neurobiol Aging. 2020 03; 87:138.e7-138.e14. Andrews SJ, Fulton-Howard B, Patterson C, McFall GP, Gross A, Michaelis EK, Goate A, Swerdlow RH, Pa J, Alzheimer's Disease Neuroimaging Initiative. PMID: 31784277; PMCID: PMC7205324.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    28. Mendelian randomization indicates that TNF is not causally associated with Alzheimer's disease. Neurobiol Aging. 2019 12; 84:241.e1-241.e3. Andrews SJ, Goate A. PMID: 31587925.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Mitochondria and Alzheimer's: Is PTCD1 the Smoking Gun? Trends Neurosci. 2019 11; 42(11):759-762. Pa J, Andrews SJ, Swerdlow RH. PMID: 31421943; PMCID: PMC7086432.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    30. Alzheimer's Environmental and Genetic Risk Scores are Differentially Associated With General Cognitive Ability and Dementia Severity. Alzheimer Dis Assoc Disord. 2019 Apr-Jun; 33(2):95-103. Andrews SJ, McFall GP, Dixon RA, Cherbuin N, Eramudugolla R, Anstey KJ. PMID: 30681434.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. Protective Variants in Alzheimer's Disease. Curr Genet Med Rep. 2019 Mar; 7(1):1-12. Andrews SJ, Fulton-Howard B, Goate A. PMID: 33117616; PMCID: PMC7591108.
      View in: PubMed   Mentions: 8  
    32. Association of Alzheimer's Disease Genetic Risk Loci with Cognitive Performance and Decline: A Systematic Review. J Alzheimers Dis. 2019; 69(4):1109-1136. Andrews SJ, McFall GP, Booth A, Dixon RA, Anstey KJ. PMID: 31156182.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    33. Association of Alzheimer's genetic loci with mild behavioral impairment. Am J Med Genet B Neuropsychiatr Genet. 2018 12; 177(8):727-735. Andrews SJ, Ismail Z, Anstey KJ, Mortby M. PMID: 30378268.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    34. Sex Differences in the Impact of BDNF Genotype on the Longitudinal Relationship between Physical Activity and Cognitive Performance. Gerontology. 2018; 64(4):361-372. Watts A, Andrews SJ, Anstey KJ. PMID: 29402782.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    35. Memory Resilience to Alzheimer's Genetic Risk: Sex Effects in Predictor Profiles. J Gerontol B Psychol Sci Soc Sci. 2017 Oct 01; 72(6):937-946. McDermott KL, McFall GP, Andrews SJ, Anstey KJ, Dixon RA. PMID: 28025282; PMCID: PMC5927155.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    36. Validating the role of the Australian National University Alzheimer's Disease Risk Index (ANU-ADRI) and a genetic risk score in progression to cognitive impairment in a population-based cohort of older adults followed for 12 years. Alzheimers Res Ther. 2017 Mar 04; 9(1):16. Andrews SJ, Eramudugolla R, Velez JI, Cherbuin N, Easteal S, Anstey KJ. PMID: 28259165; PMCID: PMC5336661.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    37. Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study. J Alzheimers Dis. 2017; 57(2):423-436. Andrews SJ, Das D, Anstey KJ, Easteal S. PMID: 28269768.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    38. Association of genetic risk factors with cognitive decline: the PATH through life project. Neurobiol Aging. 2016 May; 41:150-158. Andrews SJ, Das D, Cherbuin N, Anstey KJ, Easteal S. PMID: 27103528.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    39. Interactive effect of APOE genotype and blood pressure on cognitive decline: the PATH through life study. J Alzheimers Dis. 2015; 44(4):1087-98. Andrews S, Das D, Anstey KJ, Easteal S. PMID: 25672766.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    40. Emerging evidence for functional peptides encoded by short open reading frames. Nat Rev Genet. 2014 Mar; 15(3):193-204. Andrews SJ, Rothnagel JA. PMID: 24514441.
      View in: PubMed   Mentions: 268     Fields:    Translation:HumansAnimalsCells
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