David Klonoff, MD

TitleClinical Professor
SchoolUCSF School of Medicine
Address3333 California Street
San Francisco CA 94118
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    Collapse Education and Training
    UC BerkeleyBS1972Genetics
    UC San FranciscoMD 1976School of Medicine
    UCLA HospitalIntern and Resident1978Internal Medicine
    UC San FranciscoResident1979Internal Medicine
    UC San FranciscoEndocrinology Fellow1981Metabolic Research Unit
    Collapse Awards and Honors
    UC Berkeley  - 1971Phi Beta Kappa (Junior Year)
    UC San Francisco  - 1975Alpha Omega Alpha (Junior Year)
    American College of Physicians  - 1991FACP
    FDA  - 2010Director's Citation
    Madras (India) Diabetes Research Foundation  - 2012Gold Medal Oration Award
    American Institute of Medical and Biological Engineering  - 2013Fellow AIMBE
    Fellow of Royal College of Physicians of Edinburgh  - 2014FRCP(Edin)

    Collapse Overview 
    Collapse Overview
    David C. Klonoff, M.D. is an endocrinologist specializing in diabetes technology. He is Medical Director of the Dorothy L. and James E. Frank Diabetes Research Institute of Mills-Peninsula Medical Center in San Mateo, California and a Clinical Professor of Medicine at UCSF. Dr. Klonoff received an FDA Director’s Special Citation Award in 2010 for outstanding contributions related to diabetes technology. In 2012 Dr. Klonoff was elected as a Fellow of the American Institute of Medical and Biological Engineering (AIMBE) and cited as one of the 1000 top bioengineers in the world, as well as among the top 2% of the world’s bioengineers for his engineering work in diabetes technology. He received the 2012 Gold Medal Oration and Distinguished Scientist Award from the Dr. Mohan’s Diabetes Specialities Centre and Madras Diabetes Research Foundation of Chennai, India. Dr. Klonoff was invited to participate in the White House Health and Cybersecurity Roundtable in 2015 and to speak at the European Parliament in 2010. He is the Founding Editor-in-Chief of Journal of Diabetes Science and Technology. He has authored over 260 publications. Dr. Klonoff has been a Principal Investigator on 110 clinical trials of diabetes drugs and devices, and has been lead investigator on multicenter trials for Novo, Sanofi, Diasome, and Medtronic. He was the lead investigator for the first randomized controlled multicenter trial of an outpatient artificial pancreas product, and published the results in the New England Journal of Medicine. He chaired the scientific advisory board for the first FDA-cleared insulin patch pump and participated in developing the first FDA-cleared dedicated diabetes telemedicine system. Dr. Klonoff founded the Diabetes Technology Meeting, the Clinical Diabetes Technology Meeting, the International Hospital Diabetes Meeting, the Digital Diabetes Meeting, and the Medical Device Cybersecurity and Privacy Meeting. Dr. Klonoff has chaired or served on grant review panels for NIH, CDC, NASA, NSF, US Army, NOAA, ADA, JDRF, Yale University, University of Michigan, and Diabetes UK. He has been an advisor to NASA and is an affiliate member of the Baylor University Center for Space Medicine. Dr. Klonoff is a graduate of UC Berkeley, where he was elected to Phi Beta Kappa in his junior year, and UCSF Medical School, where he was elected to Alpha Omega Alpha in his junior year. His postgraduate training included two years at UCLA Hospital and three years at UCSF Hospitals. He was a member of the NIH Diabetes Interagency Coordinating Committee, whose ten-year research plan was released in 2011. He founded DTSec (Diabetes Technology Cybersecurity Standard for Connected Diabetes Devices Program), which created the world’s first consensus medical device cybersecurity standard. For this work Dr. Klonoff was featured in an article in Wired Magazine:


    2006-Present Editor-in-Chief, Journal of Diabetes Science and Technology
    2000-Present Medical Director, Dorothy L. and James E. Frank Diabetes Research Institute,
    Mills-Peninsula Medical Center, San Mateo, California
    1995-Present Clinical Professor, Department of Medicine, U.C. San Francisco


    1972-1976 University of California at San Francisco: M.D.
    1968-1972 University of California at Berkeley: B.S. in Genetics (with Highest Honors)

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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Klonoff DC, Kerr D, Wong JC, Pavlovic Y, Koliwad S, Hu J, Salber P, Aguilera A, Long W, Hamilton G, Chen KY, Adi S. Digital Diabetes Congress 2017. J Diabetes Sci Technol. 2017 Sep; 11(5):1045-1052. PMID: 28786320.
      View in: PubMed
    2. Liang Y, Wanderer J, Nichols JH, Klonoff D, Rice MJ. Blood Gas Analyzer Accuracy of Glucose Measurements. Mayo Clin Proc. 2017 Jul; 92(7):1030-1041. PMID: 28645518.
      View in: PubMed
    3. Wallia A, Umpierrez GE, Rushakoff RJ, Klonoff DC, Rubin DJ, Hill Golden S, Cook CB, Thompson B. Consensus Statement on Inpatient Use of Continuous Glucose Monitoring. J Diabetes Sci Technol. 2017 Sep; 11(5):1036-1044. PMID: 28429611.
      View in: PubMed
    4. Klonoff DC, Freckmann G, Heinemann L. Insulin Pump Occlusions: For Patients Who Have Been Around the (Infusion) Block. J Diabetes Sci Technol. 2017 May; 11(3):451-454. PMID: 28355924.
      View in: PubMed
    5. Pfützner A, Klonoff D, Heinemann L, Ejskjaer N, Pickup J. Euglycemic ketosis in patients with type 2 diabetes on SGLT2-inhibitor therapy-an emerging problem and solutions offered by diabetes technology. Endocrine. 2017 Apr; 56(1):212-216. PMID: 28303514.
      View in: PubMed
    6. Klonoff DC, Fleming GA, Muchmore DB, Frier BM. Hypoglycemia evaluation and reporting in diabetes: Importance for the development of new therapies. Diabetes Metab Res Rev. 2017 Jul; 33(5). PMID: 28054743.
      View in: PubMed
    7. Ginsberg BH, Klonoff DC, Crabtree VP. Meeting Report. J Diabetes Sci Technol. 2017 Mar 01; 1932296817699640. PMID: 28349709.
      View in: PubMed
    8. Klonoff DC, Price WN. The Need for a Privacy Standard for Medical Devices That Transmit Protected Health Information Used in the Precision Medicine Initiative for Diabetes and Other Diseases. J Diabetes Sci Technol. 2017 Mar; 11(2):220-223. PMID: 27920271.
      View in: PubMed
    9. Klonoff DC, Nayberg I, Stauder U, Oualali H, Domenger C. Half-Unit Insulin Pens: Disease Management in Patients With Diabetes Who Are Sensitive to Insulin. J Diabetes Sci Technol. 2017 May; 11(3):623-630. PMID: 27898389.
      View in: PubMed
    10. Drincic A, Prahalad P, Greenwood D, Klonoff DC. Evidence-based Mobile Medical Applications in Diabetes. Endocrinol Metab Clin North Am. 2016 Dec; 45(4):943-965. PMID: 27823614.
      View in: PubMed
    11. Demircik F, Klonoff D, Musholt PB, Ramljak S, Pfützner A. Successful Performance of Laboratory Investigations with Blood Glucose Meters Employing a Dynamic Electrochemistry-Based Correction Algorithm Is Dependent on Careful Sample Handling. Diabetes Technol Ther. 2016 Oct; 18(10):650-656. PMID: 27749114.
      View in: PubMed
    12. Pohlmeier H, Berard L, Brulle-Wohlhueter C, Wu J, Dahmen R, Nowotny I, Klonoff D. Ease of Use of the Insulin Glargine 300 U/mL Pen Injector in Insulin-Naïve People With Type 2 Diabetes. J Diabetes Sci Technol. 2017 Mar; 11(2):263-269. PMID: 27664062.
      View in: PubMed
    13. Wallia A, Umpierrez GE, Nasraway SA, Klonoff DC. Round Table Discussion on Inpatient Use of Continuous Glucose Monitoring at the International Hospital Diabetes Meeting. J Diabetes Sci Technol. 2016 Sep; 10(5):1174-81. PMID: 27286715.
      View in: PubMed
    14. Klonoff DC, Kerr D. Digital Diabetes Communication: There's an App for That. J Diabetes Sci Technol. 2016 Sep; 10(5):1003-5. PMID: 27464752.
      View in: PubMed
    15. Sode K, Loew N, Ohnishi Y, Tsuruta H, Mori K, Kojima K, Tsugawa W, LaBelle JT, Klonoff DC. Novel fungal FAD glucose dehydrogenase derived from Aspergillus niger for glucose enzyme sensor strips. Biosens Bioelectron. 2017 Jan 15; 87:305-311. PMID: 27573296.
      View in: PubMed
    16. Hatada M, Tsugawa W, Kamio E, Loew N, Klonoff DC, Sode K. Development of a screen-printed carbon electrode based disposable enzyme sensor strip for the measurement of glycated albumin. Biosens Bioelectron. 2017 Feb 15; 88:167-173. PMID: 27522349.
      View in: PubMed
    17. Andelin M, Kropff J, Matuleviciene V, Joseph JI, Attvall S, Theodorsson E, Hirsch IB, Imberg H, Dahlqvist S, Klonoff D, Haraldsson B, DeVries JH, Lind M. Assessing the Accuracy of Continuous Glucose Monitoring (CGM) Calibrated With Capillary Values Using Capillary or Venous Glucose Levels as a Reference. J Diabetes Sci Technol. 2016 Jul; 10(4):876-84. PMID: 26810924; PMCID: PMC4928217 [Available on 01/24/17].
    18. Carter AW, Heinemann L, Klonoff DC. Quality Control of Insulins and Biosimilar Insulins: What Do We Know? J Diabetes Sci Technol. 2016 Jul; 10(4):811-5. PMID: 26989067; PMCID: PMC4928234 [Available on 03/16/17].
    19. Klonoff DC, Lias C, Beck S, Parkes JL, Kovatchev B, Vigersky RA, Arreaza-Rubin G, Burk RD, Kowalski A, Little R, Nichols J, Petersen M, Rawlings K, Sacks DB, Sampson E, Scott S, Seley JJ, Slingerland R, Vesper HW. Development of the Diabetes Technology Society Blood Glucose Monitor System Surveillance Protocol. J Diabetes Sci Technol. 2016 May; 10(3):697-707. PMID: 26481642.
      View in: PubMed
    20. Klonoff DC, Kleidermacher DN. Now Is the Time for a Cybersecurity Standard for Connected Diabetes Devices. J Diabetes Sci Technol. 2016 May; 10(3):623-6. PMID: 27460624.
      View in: PubMed
    21. Kameya M, Tsugawa W, Yamada-Tajima M, Hatada M, Suzuki K, Sakaguchi-Mikami A, Ferri S, Klonoff DC, Sode K. Electrochemical sensing system employing fructosamine 6-kinase enables glycated albumin measurement requiring no proteolytic digestion. Biotechnol J. 2016 Jun; 11(6):797-804. PMID: 27067959.
      View in: PubMed
    22. Klonoff DC. Telemedicine for Diabetes: Economic Considerations. J Diabetes Sci Technol. 2016 Feb 07; 10(2):251-3. PMID: 26856626; PMCID: PMC4773979 [Available on 02/07/17].
    23. Klonoff DC. Telemedicine for Diabetes: Current and Future Trends. J Diabetes Sci Technol. 2015 Dec 17; 10(1):3-5. PMID: 26682960; PMCID: PMC4738230 [Available on 12/17/16].
    24. Klonoff DC. What Do Your Fingernails Say About You? Can They Indicate That You Have Diabetes? J Diabetes Sci Technol. 2015 Nov; 9(6):1167-9. PMID: 26518486; PMCID: PMC4667320 [Available on 11/01/16].
    25. Klonoff DC, Draznin B, Drincic A, Dungan K, Gianchandani R, Inzucchi SE, Nichols JH, Rice MJ, Seley JJ. PRIDE Statement on the Need for a Moratorium on the CMS Plan to Cite Hospitals for Performing Point-of-Care Capillary Blood Glucose Monitoring on Critically Ill Patients. J Clin Endocrinol Metab. 2015 Oct; 100(10):3607-12. PMID: 26398626.
      View in: PubMed
    26. Pfützner A, Sachsenheimer D, Grenningloh M, Heschel M, Walther-Johannesen L, Gharabli R, Klonoff D. Using Insulin Infusion Sets in CSII for Longer Than the Recommended Usage Time Leads to a High Risk for Adverse Events: Results From a Prospective Randomized Crossover Study. J Diabetes Sci Technol. 2015 Sep 03; 9(6):1292-8. PMID: 26341262; PMCID: PMC4667306.
    27. Armstrong DG, Kleidermacher DN, Klonoff DC, Slepian MJ. Cybersecurity Regulation of Wireless Devices for Performance and Assurance in the Age of "Medjacking". J Diabetes Sci Technol. 2015 Aug 27; 10(2):435-8. PMID: 26319227; PMCID: PMC4773954.
    28. Klonoff D, Nayberg I, Thonius M, See F, Abdel-Tawab M, Erbstein F, Haak T. Accuracy and Injection Force of the Gla-300 Injection Device Compared With Other Commercialized Disposable Insulin Pens. J Diabetes Sci Technol. 2015 Aug 26; 10(1):125-30. PMID: 26311720; PMCID: PMC4738217.
    29. Klonoff DC, Prahalad P. Performance of Cleared Blood Glucose Monitors. J Diabetes Sci Technol. 2015 Jul; 9(4):895-910. PMID: 25990294; PMCID: PMC4525666.
    30. Cembrowski G, Lyon ME, Klonoff DC. Glucose data-mining study inconclusive. Can J Diabetes. 2015 Oct; 39(5):354-5. PMID: 26028478.
      View in: PubMed
    31. Klonoff D, Nayberg I, Erbstein F, Cali A, Brulle-Wohlhueter C, Haak T. Usability of the Gla-300 Injection Device Compared With Three Other Commercialized Disposable Insulin Pens: Results of an Interview-Based Survey. J Diabetes Sci Technol. 2015 Jul; 9(4):936-8. PMID: 26002837; PMCID: PMC4525641.
    32. Weiss R, Garg SK, Bergenstal RM, Klonoff DC, Bode BW, Bailey TS, Thrasher J, Schwartz F, Welsh JB, Kaufman FR. Predictors of Hypoglycemia in the ASPIRE In-Home Study and Effects of Automatic Suspension of Insulin Delivery. J Diabetes Sci Technol. 2015 May 18; 9(5):1016-20. PMID: 25986629; PMCID: PMC4667346.
    33. Klonoff DC. Cybersecurity for Connected Diabetes Devices. J Diabetes Sci Technol. 2015 Apr 16; 9(5):1143-7. PMID: 25883162; PMCID: PMC4667325.
    34. Klonoff DC. Trends in FDA regulation of software to control insulin dosing. J Diabetes Sci Technol. 2015 May; 9(3):503-6. PMID: 25872966; PMCID: PMC4604554.
    35. Klonoff D, Nayberg I, Rabbone I, Domenger C, Stauder U, Oualali H, Danne T. Functional Evaluation of the Reusable JuniorSTAR® Half-Unit Insulin Pen. J Diabetes Sci Technol. 2015 May; 9(3):625-31. PMID: 25633967; PMCID: PMC4604544.
    36. Klonoff DC. Precision medicine for managing diabetes. J Diabetes Sci Technol. 2015 Jan; 9(1):3-7. PMID: 25550409; PMCID: PMC4495533.
    37. Klonoff DC. Afrezza inhaled insulin: the fastest-acting FDA-approved insulin on the market has favorable properties. J Diabetes Sci Technol. 2014 Nov; 8(6):1071-3. PMID: 25355710; PMCID: PMC4455463.
    38. Landau Z, Klonoff D, Nayberg I, Feldman D, Levit SB, Lender D, Mosenzon O, Raz I, Wainstein J. Improved pharmacokinetic and pharmacodynamic profiles of insulin analogues using InsuPatch, a local heating device. Diabetes Metab Res Rev. 2014 Nov; 30(8):686-92. PMID: 24610683.
      View in: PubMed
    39. Pfützner A, Raz I, Bitton G, Klonoff D, Nagar R, Hermanns N, Haak T. Improved insulin absorption by means of standardized injection site modulation results in a safer and more efficient prandial insulin treatment. A review of the existing clinical data. J Diabetes Sci Technol. 2015 Jan; 9(1):116-22. PMID: 25352633; PMCID: PMC4495536.
    40. Matuleviciene V, Joseph JI, Andelin M, Hirsch IB, Attvall S, Pivodic A, Dahlqvist S, Klonoff D, Haraldsson B, Lind M. A clinical trial of the accuracy and treatment experience of the Dexcom G4 sensor (Dexcom G4 system) and Enlite sensor (guardian REAL-time system) tested simultaneously in ambulatory patients with type 1 diabetes. Diabetes Technol Ther. 2014 Nov; 16(11):759-67. PMID: 25233297; PMCID: PMC4201312.
    41. Klonoff DC, Vigersky RA, Nichols JH, Rice MJ. Timely hospital glucose measurement: here today, gone tomorrow? Mayo Clin Proc. 2014 Oct; 89(10):1331-5. PMID: 25199860.
      View in: PubMed
    42. Klonoff DC, Reyes JS. Hospital diabetes meeting: Arlington, Virginia, May 13, 2014. J Diabetes Sci Technol. 2014 Sep; 8(5):1048-51. PMID: 25172880; PMCID: PMC4455365.
    43. Klonoff DC. Point-of-Care Blood Glucose Meter Accuracy in the Hospital Setting. Diabetes Spectr. 2014 Aug; 27(3):174-9. PMID: 26246776; PMCID: PMC4523734.
    44. Kovatchev BP, Wakeman CA, Breton MD, Kost GJ, Louie RF, Tran NK, Klonoff DC. Computing the surveillance error grid analysis: procedure and examples. J Diabetes Sci Technol. 2014 Jul; 8(4):673-84. PMID: 25562887; PMCID: PMC4764239.
    45. Klonoff DC, Lias C, Vigersky R, Clarke W, Parkes JL, Sacks DB, Kirkman MS, Kovatchev B. The surveillance error grid. J Diabetes Sci Technol. 2014 Jul; 8(4):658-72. PMID: 25562886; PMCID: PMC4764212.
    46. Klonoff DC. ADAG study group data links A1C levels with empirically measured blood glucose values - new treatment guidelines will now be needed. J Diabetes Sci Technol. 2014 May; 8(3):439-43. PMID: 24876603; PMCID: PMC4455453.
    47. Garg SK, Brazg RL, Bailey TS, Buckingham BA, Slover RH, Klonoff DC, Shin J, Welsh JB, Kaufman FR. Hypoglycemia begets hypoglycemia: the order effect in the ASPIRE in-clinic study. Diabetes Technol Ther. 2014 Mar; 16(3):125-30. PMID: 24405492.
      View in: PubMed
    48. Klonoff DC. New Wearable Computers Move Ahead: Google Glass and Smart Wigs. J Diabetes Sci Technol. 2014 Jan; 8(1):3-5. PMID: 24876529.
      View in: PubMed
    49. Pfützner A, Klonoff DC, Pardo S, Parkes JL. Technical aspects of the Parkes error grid. J Diabetes Sci Technol. 2013 Sep 01; 7(5):1275-81. PMID: 24124954; PMCID: PMC3876371.
    50. Heinemann L, Klonoff DC. Freedom of speech and science: can companies force us to withdraw data they don't like? J Diabetes Sci Technol. 2013 Sep 01; 7(5):1100-1. PMID: 24124934; PMCID: PMC3876351.
    51. Chaudhry T, Klonoff DC. SMBG out of control: the need for educating patients about control solution. Diabetes Educ. 2013 Sep-Oct; 39(5):689-95. PMID: 23897920.
      View in: PubMed
    52. Draznin B, Gilden J, Golden SH, Inzucchi SE, Baldwin D, Bode BW, Boord JB, Braithwaite SS, Cagliero E, Dungan KM, Falciglia M, Figaro MK, Hirsch IB, Klonoff D, Korytkowski MT, Kosiborod M, Lien LF, Magee MF, Masharani U, Maynard G, McDonnell ME, Moghissi ES, Rasouli N, Rubin DJ, Rushakoff RJ, Sadhu AR, Schwartz S, Seley JJ, Umpierrez GE, Vigersky RA, Low CC, Wexler DJ. Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action. Diabetes Care. 2013 Jul; 36(7):1807-14. PMID: 23801791; PMCID: PMC3687296.
    53. Klonoff DC, Reyes JS. Do currently available blood glucose monitors meet regulatory standards? 1-day public meeting in Arlington, Virginia. J Diabetes Sci Technol. 2013 Jul 01; 7(4):1071-83. PMID: 23911191; PMCID: PMC3879774.
    54. Klonoff DC, Bergenstal RM, Garg SK, Bode BW, Meredith M, Slover RH, Ahmann A, Welsh JB, Lee SW. ASPIRE In-Home: rationale, design, and methods of a study to evaluate the safety and efficacy of automatic insulin suspension for nocturnal hypoglycemia. J Diabetes Sci Technol. 2013 Jul 01; 7(4):1005-10. PMID: 23911183; PMCID: PMC3879766.
    55. Bergenstal RM, Klonoff DC, Garg SK, Bode BW, Meredith M, Slover RH, Ahmann AJ, Welsh JB, Lee SW, Kaufman FR. Threshold-based insulin-pump interruption for reduction of hypoglycemia. N Engl J Med. 2013 Jul 18; 369(3):224-32. PMID: 23789889.
      View in: PubMed
    56. Klonoff DC. The current status of mHealth for diabetes: will it be the next big thing? J Diabetes Sci Technol. 2013 May 01; 7(3):749-58. PMID: 23759409; PMCID: PMC3869144.
    57. Heinemann L, Klonoff DC. Blood glucose meter market: this world is undergoing drastic changes. J Diabetes Sci Technol. 2013 May 01; 7(3):584-6. PMID: 23759389; PMCID: PMC3869124.
    58. Pfützner A, Bailey T, Campos C, Kahn D, Ambers E, Niemeyer M, Guerrero G, Klonoff D, Nayberg I. Accuracy and preference assessment of prefilled insulin pen versus vial and syringe with diabetes patients, caregivers, and healthcare professionals. Curr Med Res Opin. 2013 May; 29(5):475-81. PMID: 23402225.
      View in: PubMed
    59. Bergenstal RM, Ahmann AJ, Bailey T, Beck RW, Bissen J, Buckingham B, Deeb L, Dolin RH, Garg SK, Goland R, Hirsch IB, Klonoff DC, Kruger DF, Matfin G, Mazze RS, Olson BA, Parkin C, Peters A, Powers MA, Rodriguez H, Southerland P, Strock ES, Tamborlane W, Wesley DM. Recommendations for standardizing glucose reporting and analysis to optimize clinical decision making in diabetes: the ambulatory glucose profile. J Diabetes Sci Technol. 2013 Mar 01; 7(2):562-78. PMID: 23567014; PMCID: PMC3737658.
    60. Klonoff DC. Twelve modern digital technologies that are transforming decision making for diabetes and all areas of health care. J Diabetes Sci Technol. 2013 Mar 01; 7(2):291-5. PMID: 23566983; PMCID: PMC3737626.
    61. Bergenstal RM, Ahmann AJ, Bailey T, Beck RW, Bissen J, Buckingham B, Deeb L, Dolin RH, Garg SK, Goland R, Hirsch IB, Klonoff DC, Kruger DF, Matfin G, Mazze RS, Olson BA, Parkin C, Peters A, Powers MA, Rodriguez H, Southerland P, Strock ES, Tamborlane W, Wesley DM. Recommendations for standardizing glucose reporting and analysis to optimize clinical decision making in diabetes: the Ambulatory Glucose Profile (AGP). Diabetes Technol Ther. 2013 Mar; 15(3):198-211. PMID: 23448694.
      View in: PubMed
    62. Klonoff DC. Overview of fluorescence glucose sensing: a technology with a bright future. J Diabetes Sci Technol. 2012 Nov 01; 6(6):1242-50. PMID: 23294768; PMCID: PMC3570863.
    63. Klonoff DC. The current status of bolus calculator decision-support software. J Diabetes Sci Technol. 2012 Sep 01; 6(5):990-4. PMID: 23063023; PMCID: PMC3570831.
    64. Klonoff DC. Improved outcomes from diabetes monitoring: the benefits of better adherence, therapy adjustments, patient education, and telemedicine support. J Diabetes Sci Technol. 2012 May 01; 6(3):486-90. PMID: 22768877; PMCID: PMC3440062.
    65. Garg S, Brazg RL, Bailey TS, Buckingham BA, Slover RH, Klonoff DC, Shin J, Welsh JB, Kaufman FR. Reduction in duration of hypoglycemia by automatic suspension of insulin delivery: the in-clinic ASPIRE study. Diabetes Technol Ther. 2012 Mar; 14(3):205-9. PMID: 22316089.
      View in: PubMed
    66. Klonoff DC. The need for clinical accuracy guidelines for blood glucose monitors. J Diabetes Sci Technol. 2012 Jan 01; 6(1):1-4. PMID: 22401316; PMCID: PMC3320815.
    67. Paul N, Kohno T, Klonoff DC. A review of the security of insulin pump infusion systems. J Diabetes Sci Technol. 2011 Nov 01; 5(6):1557-62. PMID: 22226278; PMCID: PMC3262727.
    68. Klonoff DC, Blonde L, Cembrowski G, Chacra AR, Charpentier G, Colagiuri S, Dailey G, Gabbay RA, Heinemann L, Kerr D, Nicolucci A, Polonsky W, Schnell O, Vigersky R, Yale JF. Consensus report: the current role of self-monitoring of blood glucose in non-insulin-treated type 2 diabetes. J Diabetes Sci Technol. 2011 Nov 01; 5(6):1529-48. PMID: 22226276; PMCID: PMC3262725.
    69. Brazg RL, Bailey TS, Garg S, Buckingham BA, Slover RH, Klonoff DC, Nguyen X, Shin J, Welsh JB, Lee SW. The ASPIRE study: design and methods of an in-clinic crossover trial on the efficacy of automatic insulin pump suspension in exercise-induced hypoglycemia. J Diabetes Sci Technol. 2011 Nov 01; 5(6):1466-71. PMID: 22226267; PMCID: PMC3262716.
    70. Klonoff DC. Improving the safety of blood glucose monitoring. J Diabetes Sci Technol. 2011 Nov 01; 5(6):1307-11. PMID: 22226247; PMCID: PMC3262696.
    71. Klonoff DC, Buckingham B, Christiansen JS, Montori VM, Tamborlane WV, Vigersky RA, Wolpert H. Continuous glucose monitoring: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011 Oct; 96(10):2968-79. PMID: 21976745.
      View in: PubMed
    72. Klonoff DC, Zimliki CL, Stevens LA, Beaston P, Pinkos A, Choe SY, Arreaza-Rubín G, Heetderks W. Innovations in technology for the treatment of diabetes: clinical development of the artificial pancreas (an autonomous system). J Diabetes Sci Technol. 2011 May 01; 5(3):804-26. PMID: 21722597; PMCID: PMC3192648.
    73. Klonoff DC. Intensive insulin therapy in critically ill hospitalized patients: making it safe and effective. J Diabetes Sci Technol. 2011 May 01; 5(3):755-67. PMID: 21722591; PMCID: PMC3192642.
    74. Klonoff DC. Smart sensors for maintaining physiologic homeostasis. J Diabetes Sci Technol. 2011 May 01; 5(3):470-5. PMID: 21722562; PMCID: PMC3192613.
    75. Klonoff DC. Hospital diabetes: why quality of care matters to both patients and hospitals. J Diabetes Sci Technol. 2011 Jan 01; 5(1):1-4. PMID: 21303618; PMCID: PMC3045235.
    76. Klonoff DC. Incretin therapy for type 2 diabetes mellitus. Adv Ther. 2010 Dec; 27(12):881-94. PMID: 20978879.
      View in: PubMed
    77. Klonoff DC, Perz JF. Assisted monitoring of blood glucose: special safety needs for a new paradigm in testing glucose. J Diabetes Sci Technol. 2010 Sep 01; 4(5):1027-31. PMID: 20920422; PMCID: PMC2956804.
    78. Klonoff DC. Fibroblast growth factor: will this hormone be the hemoglobin A1c for managing phosphorus balance in chronic kidney disease? J Diabetes Sci Technol. 2010 Jul 01; 4(4):770-2. PMID: 20663436; PMCID: PMC2909504.
    79. Klonoff DC. The food and drug administration is now preparing to establish tighter performance requirements for blood glucose monitors. J Diabetes Sci Technol. 2010 May 01; 4(3):499-504. PMID: 20513313; PMCID: PMC2901024.
    80. Zhang Y, Jones PL, Klonoff DC. Second insulin pump safety meeting: summary report. J Diabetes Sci Technol. 2010 Mar 01; 4(2):488-93. PMID: 20307411; PMCID: PMC2864186.
    81. Klonoff DC. Regulatory controversies surround blood glucose monitoring devices. J Diabetes Sci Technol. 2010 Mar 01; 4(2):231-5. PMID: 20307381; PMCID: PMC2864156.
    82. Klonoff DC. The need for a glycemia modeling comparison workshop to facilitate development of an artificial pancreas. J Diabetes Sci Technol. 2010 Jan 01; 4(1):1-3. PMID: 20167161; PMCID: PMC2825618.
    83. Klonoff DC. The beneficial effects of a Paleolithic diet on type 2 diabetes and other risk factors for cardiovascular disease. J Diabetes Sci Technol. 2009 Nov 01; 3(6):1229-32. PMID: 20144375; PMCID: PMC2787021.
    84. Klonoff DC, Cobelli C, Kovatchev B, Zisser HC. Progress in development of an artificial pancreas. J Diabetes Sci Technol. 2009 Sep 01; 3(5):1002-4. PMID: 20144412; PMCID: PMC2769889.
    85. Klonoff DC, True MW. The missing element of telemedicine for diabetes: decision support software. J Diabetes Sci Technol. 2009 Sep 01; 3(5):996-1001. PMID: 20144411; PMCID: PMC2769905.
    86. Klonoff DC. The personalized medicine for diabetes meeting summary report. J Diabetes Sci Technol. 2009 Jul 01; 3(4):677-9. PMID: 20144312; PMCID: PMC2769958.
    87. Klonoff DC. Using telemedicine to improve outcomes in diabetes--an emerging technology. J Diabetes Sci Technol. 2009 Jul 01; 3(4):624-8. PMID: 20144303; PMCID: PMC2769943.
    88. Klonoff DC. A sweetened beverage tax is needed to combat the obesity epidemicas well as related absenteeism and presenteeism. J Diabetes Sci Technol. 2009 May 01; 3(3):408-10. PMID: 20144275; PMCID: PMC2769883.
    89. Klonoff DC, Reyes JS. Insulin pump safety meeting: summary report. J Diabetes Sci Technol. 2009 Mar 01; 3(2):396-402. PMID: 20144372; PMCID: PMC2771530.
    90. Fleming GA, Klonoff DC. Glutamic Acid decarboxylase therapy for recent-onset type 1 diabetes: are we at the end or the beginning of finding a cure? J Diabetes Sci Technol. 2009 Mar 01; 3(2):215-8. PMID: 20144352; PMCID: PMC2771509.
    91. Klonoff DC. Continuous glucose monitoring study does not demonstrate benefit in children and adolescents. J Pediatr. 2009 Mar; 154(3):463-4. PMID: 19874771.
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    92. Klonoff DC. The increasing incidence of diabetes in the 21st century. J Diabetes Sci Technol. 2009 Jan; 3(1):1-2. PMID: 20046646; PMCID: PMC2769839.
    93. Klonoff DC, Bergenstal R, Blonde L, Boren SA, Church TS, Gaffaney J, Jovanovic L, Kendall DM, Kollman C, Kovatchev BP, Leippert C, Owens DR, Polonsky WH, Reach G, Renard E, Riddell MC, Rubin RR, Schnell O, Siminiero LM, Vigersky RA, Wilson DM, Wollitzer AO. Consensus report of the coalition for clinical research-self-monitoring of blood glucose. J Diabetes Sci Technol. 2008 Nov; 2(6):1030-53. PMID: 19885292; PMCID: PMC2769823.
    94. Klonoff DC. United Kingdom prospective diabetes study follow-up studies establish a legacy effect of therapy for hyperglycemia but not hypertension. J Diabetes Sci Technol. 2008 Nov; 2(6):922-4. PMID: 19885280; PMCID: PMC2769819.
    95. Klonoff DC, Greenway F. Drugs in the pipeline for the obesity market. J Diabetes Sci Technol. 2008 Sep; 2(5):913-8. PMID: 19885278; PMCID: PMC2769782.
    96. Klonoff DC. Designing an artificial pancreas system to be compatible with other medical devices. J Diabetes Sci Technol. 2008 Sep; 2(5):741-5. PMID: 19885256; PMCID: PMC2769781.
    97. Rosenstock J, Bergenstal R, Defronzo RA, Hirsch IB, Klonoff D, Boss AH, Kramer D, Petrucci R, Yu W, Levy B. Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents. Diabetes Care. 2008 Nov; 31(11):2177-82. PMID: 18678610; PMCID: PMC2571070.
    98. Klonoff DC. Spending for diabetes drugs is increasing in the United States. J Diabetes Sci Technol. 2008 Jul; 2(4):543-5. PMID: 19885226; PMCID: PMC2769766.
    99. Klonoff DC. New evidence demonstrates that self-monitoring of blood glucose does not improve outcomes in type 2 diabetes-when this practice is not applied properly. J Diabetes Sci Technol. 2008 May; 2(3):342-8. PMID: 19885197; PMCID: PMC2769720.
    100. Klonoff DC. Personalized medicine for diabetes. J Diabetes Sci Technol. 2008 May; 2(3):335-41. PMID: 19885196; PMCID: PMC2769744.
    101. Klonoff DC. Summary of Seventh Annual Diabetes Technology Meeting October 25-27, 2007 San Francisco, California. J Diabetes Sci Technol. 2008 Mar; 2(2):316-A187. PMID: 19885363; PMCID: PMC2771484.
    102. Klonoff DC. The "catalyst to better diabetes care act of 2007". J Diabetes Sci Technol. 2008 Mar; 2(2):175-7. PMID: 19885339; PMCID: PMC2771497.
    103. Klonoff DC. Business and economics of diabetes. J Diabetes Sci Technol. 2008 Jan; 2(1):1-3. PMID: 19885170; PMCID: PMC2769700.
    104. Klonoff DC, Buse JB, Nielsen LL, Guan X, Bowlus CL, Holcombe JH, Wintle ME, Maggs DG. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin. 2008 Jan; 24(1):275-86. PMID: 18053320.
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    105. Klonoff DC. The benefits of implanted glucose sensors. J Diabetes Sci Technol. 2007 Nov; 1(6):797-800. PMID: 19885150; PMCID: PMC2769691.
    106. Klonoff DC. The new food and drug administration center for devices and radiological health engineering and physics laboratory and methods for testing software that controls infusion pumps. J Diabetes Sci Technol. 2007 Sep; 1(5):608-11. PMID: 19885126; PMCID: PMC2769651.
    107. Klonoff DC. Bariatric surgery for obese adolescents. J Diabetes Sci Technol. 2007 Jul; 1(4):451-3. PMID: 19885106; PMCID: PMC2769630.
    108. Klonoff DC. Replacements for trans fats-will there be an oil shortage? J Diabetes Sci Technol. 2007 May; 1(3):415-22. PMID: 19885099; PMCID: PMC2769584.
    109. Klonoff DC. Dirlotapide, a U.S. Food and Drug Administration-approved first-in-class obesity drug for dogs-will humans be next? J Diabetes Sci Technol. 2007 May; 1(3):314-6. PMID: 19885086; PMCID: PMC2769592.
    110. Klonoff DC. Subcutaneous continuous glucose monitoring in severe burn patients. Crit Care Med. 2007 May; 35(5):1445; author reply 1445-6. PMID: 17446759.
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    111. Klonoff DC. Summary of Sixth Annual Diabetes Technology Meeting, November 2-4, 2006, Atlanta, Georgia. J Diabetes Sci Technol. 2007 Mar; 1(2):264--7. PMID: 19888416; PMCID: PMC2771461.
    112. Klonoff DC. Technology to treat hyperglycemia in trauma. J Diabetes Sci Technol. 2007 Mar; 1(2):151-2. PMID: 19888398; PMCID: PMC2771477.
    113. Klonoff DC. Benefits and limitations of self-monitoring of blood glucose. J Diabetes Sci Technol. 2007 Jan; 1(1):130-2. PMID: 19888392; PMCID: PMC2769614.
    114. Nichols JH, Klonoff DC. The need for performance standards for continuous glucose monitors. J Diabetes Sci Technol. 2007 Jan; 1(1):92-4. PMID: 19888385; PMCID: PMC2769611.
    115. Klonoff DC. The artificial pancreas: how sweet engineering will solve bitter problems. J Diabetes Sci Technol. 2007 Jan; 1(1):72-81. PMID: 19888383; PMCID: PMC2769610.
    116. Buse JB, Klonoff DC, Nielsen LL, Guan X, Bowlus CL, Holcombe JH, Maggs DG, Wintle ME. Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials. Clin Ther. 2007 Jan; 29(1):139-53. PMID: 17379054.
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    117. Klonoff DC. A review of continuous glucose monitoring technology. Diabetes Technol Ther. 2005 Oct; 7(5):770-5. PMID: 16241880.
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    118. Crowe DJ, Klonoff DC. Time synching or time sinking? Diabetes Technol Ther. 2005 Oct; 7(5):663-4. PMID: 16241864.
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    119. Klonoff DC. Pyruvate therapy for severe hypoglycemia. Diabetes Technol Ther. 2005 Aug; 7(4):583-6. PMID: 16120029.
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    120. Klonoff DC. Continuous glucose monitoring: roadmap for 21st century diabetes therapy. Diabetes Care. 2005 May; 28(5):1231-9. PMID: 15855600.
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    121. Simmons M, Gillett D, Catanzaro B, Jacobs B, Klonoff DC, Sage B. An adaptive drug infusion system. Diabetes Technol Ther. 2004 Oct; 6(5):607-20. PMID: 15628815.
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    122. Klonoff DC. The need for separate performance goals for glucose sensors in the hypoglycemic, normoglycemic, and hyperglycemic ranges. Diabetes Care. 2004 Mar; 27(3):834-6. PMID: 14988313.
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    123. Klonoff DC. Technological advances in the treatment of diabetes mellitus: better bioengineering begets benefits in glucose measurement, the artificial pancreas, and insulin delivery. Pediatr Endocrinol Rev. 2003 Dec; 1(2):94-100. PMID: 16437014.
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    124. Klonoff DC. Diabetes and telemedicine: is the technology sound, effective, cost-effective, and practical? Diabetes Care. 2003 May; 26(5):1626-8. PMID: 12716831.
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    125. Klonoff DC. Technology for portable measurement of blood lactate. Diabetes Technol Ther. 2003; 5(6):929-31. PMID: 14709194.
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    126. Klonoff DC. Microdialysis of interstitial fluid for continuous glucose measurement. Diabetes Technol Ther. 2003; 5(4):539-43. PMID: 14511409.
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    127. Klonoff DC. The link between diabetes, military metabolic monitoring, and NASA. Diabetes Technol Ther. 2003; 5(3):351-3. PMID: 12833916.
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    128. Klonoff DC. A flaw in the use of sulfonylurea screening to diagnose sulfonylurea overdosages. Diabetes Technol Ther. 2003; 5(3):453-4. PMID: 12828830.
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    129. Klonoff DC. European trends in diabetes technology--continuous glucose measurements and computerized information-processing tools. Diabetes Technol Ther. 2002; 4(6):763-4. PMID: 12614486.
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    130. Klonoff DC. Current, emerging, and future trends in metabolic monitoring. Diabetes Technol Ther. 2002; 4(5):583-8. PMID: 12450438.
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    131. Hopmeier M, Glenn JF, Goldstein R, Hines J, Friedl K, Hunter-Schaedle K, Laughlin M, Loew M, Klonoff D. Technologies for Metabolic Monitoring (TMM): a new research initiative. Diabetes Technol Ther. 2002; 4(4):539-41. PMID: 12396749.
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    132. Klonoff DC. The First Annual Diabetes Technology Meeting--a new forum for accelerating the development of technology to fight diabetes. Diabetes Technol Ther. 2002; 4(2):201-2. PMID: 12079624.
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    133. Klonoff DC. FDA approves new glucose test for adult diabetics. Diabetes Technol Ther. 2001; 3(2):281. PMID: 11478334.
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    134. Klonoff DC. Special funding boosts type 1 diabetes research. Diabetes Technol Ther. 2001; 3(2):282. PMID: 11478335.
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    135. Klonoff DC. The need for hypoglycemia detection and prevention in type 1 diabetes. Diabetes Technol Ther. 2001; 3(4):567-70. PMID: 11911168.
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    136. Klonoff DC. The pen is mightier than the needle (and syringe). Diabetes Technol Ther. 2001; 3(4):631-3. PMID: 11911176.
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    137. Klonoff DC, Schwartz DM. An economic analysis of interventions for diabetes. Diabetes Care. 2000 Mar; 23(3):390-404. PMID: 10868871.
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    138. Klonoff DC. Serum fructosamine as a screening test for type 2 diabetes. Diabetes Technol Ther. 2000; 2(4):537-9. PMID: 11469616.
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    139. Klonoff DC. Allen M. Spiegel, M.D., named Director of NIDDK. Diabetes Technol Ther. 2000; 2(1):123. PMID: 11467311.
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    140. Klonoff DC. Clinical chemistry and clinical toxicology devices advisory panel recommendation on Glucowatch. Diabetes Technol Ther. 2000; 2(1):125-6. PMID: 11467313.
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    141. Klonoff DC. NIAID spearheads collaborative network for clinical research on immune tolerance. Diabetes Technol Ther. 2000; 2(1):124-5. PMID: 11467312.
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    142. Klonoff DC. Diabetes Prevention Program meets recruitment goals. Diabetes Technol Ther. 1999; 1(3):350-1. PMID: 11475280.
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    143. Klonoff DC. FDA approves new Glucose Monitoring System. Diabetes Technol Ther. 1999; 1(3):349. PMID: 11475279.
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    144. Klonoff DC. New products and new technologies for diabetes. Diabetes Technol Ther. 1999; 1(3):237-8. PMID: 11475267.
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    145. Klonoff DC. Expressing the sense of the Senate to raise the awareness of the devastating impact of diabetes and to support increased funds for diabetes research. Diabetes Technol Ther. 1999; 1(4):525-7. PMID: 11474837.
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    146. Klonoff DC. The UCSF Diabetes Symposium: Research Breakthroughs in Diabetes. Diabetes Technol Ther. 1999; 1(3):339-40. PMID: 11512541.
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    147. Klonoff DC. FDA Clinical Chemistry and Clinical Toxicology Devices Panel. Diabetes Technol Ther. 1999; 1(2):201-2. PMID: 11475293.
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    148. Klonoff DC. The promise of optical sensing strategies for glucose. Diabetes Technol Ther. 1999; 1(4):401-2. PMID: 11474823.
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    149. Klonoff DC. Inhaled insulin. Diabetes Technol Ther. 1999; 1(3):307-13. PMID: 11475277.
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    150. Klonoff DC. New labeling and use changes for Rezulin. Diabetes Technol Ther. 1999; 1(3):350. PMID: 11484719.
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    151. Klonoff DC. Noninvasive blood glucose monitoring. Diabetes Care. 1997 Mar; 20(3):433-7. PMID: 9051401.
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    152. Klonoff DC. Chronic fatigue syndrome and neurally mediated hypotension. JAMA. 1996 Feb 07; 275(5):359-60. PMID: 8569010.
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    153. Klonoff DC, Barrett BJ, Nolte MS, Cohen RM, Wyderski R. Hypoglycemia following inadvertent and factitious sulfonylurea overdosages. Diabetes Care. 1995 Apr; 18(4):563-7. PMID: 7497872.
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    154. Klonoff DC, Wiskocil RL. Inappropriate drug prescribing. JAMA. 1995 Feb 08; 273(6):456-7. PMID: 7837357.
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    155. Klonoff DC. Chronic fatigue syndrome. Clin Infect Dis. 1992 Nov; 15(5):812-23. PMID: 1445980.
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    156. Demeure MJ, Klonoff DC, Karam JH, Duh QY, Clark OH. Insulinomas associated with multiple endocrine neoplasia type I: the need for a different surgical approach. Surgery. 1991 Dec; 110(6):998-1004; discussion 1004-5. PMID: 1684067.
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    157. Klonoff DC, Jurow AH. Acute water intoxication as a complication of urine drug testing in the workplace. JAMA. 1991 Jan 02; 265(1):84-5. PMID: 1984128.
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    158. Klonoff DC, Kahn DG, Rosenzweig W, Wilson CB. Hyperprolactinemia in a patient with a pituitary and an ovarian dermoid tumor: case report. Neurosurgery. 1990 Feb; 26(2):335-9. PMID: 2308685.
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    159. Klonoff DC, Andrews BT, Obana WG. Stroke associated with cocaine use. Arch Neurol. 1989 Sep; 46(9):989-93. PMID: 2673163.
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    160. Klonoff DC. Association of hyperinsulinemia with chlorpropamide toxicity. Am J Med. 1988 Jan; 84(1):33-8. PMID: 3276184.
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    161. Kahn DG, Garfinkle JM, Klonoff DC, Pembrook LJ, Morrow DJ. Cryptosporidial and cytomegaloviral hepatitis and cholecystitis. Arch Pathol Lab Med. 1987 Sep; 111(9):879-81. PMID: 2820346.
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    162. Klonoff DC, Greenspan FS. The thyroid nodule. Adv Intern Med. 1982; 27:101-26. PMID: 7041541.
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    163. Klonoff DC. Macroamylasemia and other immunoglobulin-complexed enzyme disorders. West J Med. 1980 Nov; 133(5):392-407. PMID: 6162278; PMCID: PMC1272350.
    164. Mohsenifar Z, Klonoff D, Cassan S. Propionibacterium acnes pneumonia in a patient with lymphoma. Infection. 1979; 7(3):146-8. PMID: 478654.
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