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67O Polygenic risk score associations with immune checkpoint inhibitors related endocrine toxicity. Annals of Oncology. 2024 Sep 1; 35:s240-s241.
Thorball TC, Quandt QZ, Saha SA, Yao YL, Midda MP, Xu XY, Bejan BC, Hodel HF, Stravodimou SA, Shearer-Kang SE, Aldrich AM, Philips PE, Liu LG, Schoenfeld SA, Johnson JD, Ziv ZE, Fellay FJ, Mohindra MR, Balko BJ, Chandler CG. .
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Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease. Cold Spring Harb Perspect Med. 2024 Jul 22.
Quandt Z, Perdigoto A, Anderson MS, Herold KC. PMID: 39038853.
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PubMed Mentions: Fields:
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Phase II trial of pembrolizumab, ipilimumab, and aspirin in melanoma: clinical outcomes and translational predictors of response. BJC Rep. 2024 Jun 24; 2(1):46.
Quandt Z, Jacob S, Fadlullah MZH, Wu C, Wu C, Huppert L, Levine LS, Sison P, Tsai KK, Chow M, Kang JH, Hwang J, Lee JC, Oglesby A, Venegas J, Brintz BJ, Tan AC, Anderson MS, Rosenblum MD, Young A, Daud AI. PMID: 39516257; PMCID: PMC11524064.
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Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events. medRxiv. 2024 Jun 11.
Middha P, Thummalapalli R, Quandt Z, Balaratnam K, Cardenas E, Falcon CJ, Princess Margaret Lung Group, Gubens MA, Huntsman S, Khan K, Li M, Lovly CM, Patel D, Zhan LJ, Liu G, Aldrich MC, Schoenfeld AJ, Ziv E. PMID: 38947092; PMCID: PMC11213033.
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Incidence and time to onset of immunotherapy-related adrenal insufficiency in the I-SPY2 trial. Journal of Clinical Oncology. 2024 Jun 1; 42(16_suppl):584-584.
Nanda NR, Cohen CR, Quandt QZ, Basu BA, Yau YC, Chien CA, Pusztai PL, Han HH, Stringer-Reasor SE, Isaacs IC, Hershman HD, Shatsky SR, Perlmutter PJ, Yee YD, DeMichele DA, van 't Veer vL, Hylton HN, Esserman EL, Rugo RH. .
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HLA associations with immunotherapy related endocrine toxicity. Journal of Clinical Oncology. 2024 Jun 1; 42(16_suppl):2516-2516.
Quandt QZ, Thorball TC, Middha MP, Johnson JD, Bejan BC, Yao YL, Xu XY, Hodel HF, Stravodimou SA, Shearer-Kang SE, Liu LG, Aldrich AM, Schoenfeld SA, Ziv ZE, Phillips PE, Fellay FJ, Bergmann BE, Chandler CG, Balko BJ, Saha SA. .
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Association of germline polygenic risk for thyroid autoimmunity with overall survival in the I-SPY2 Trial. Journal of Clinical Oncology. 2024 Jun 1; 42(16_suppl):10600-10600.
Fergus FK, Middha MP, Quandt QZ, Shieh SY, Basu BA, Sayaman SR, Pohlmann PP, Yee YD, Shatsky SR, Isaacs IC, Campbell CM, Hirst HG, Brown Swigart BL, van 't Veer vL, Ziv ZE, Esserman EL. .
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Abstract PS14-03: Delayed and post-treatment immune toxicities in patients with breast cancer receiving immune checkpoint inhibitors. Cancer Research. 2024 May 2; 84(9_Supplement):ps14-03-ps14-03.
Jacob JS, Fisch FS, Face FC, Huppert HL, Quandt QZ, Quintal QL, Melisko MM, Majure MM, Chien CJ, Blaes BA, Rugo RH. .
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Outcomes and Adverse Events in Patients with Cancer after Diagnosis of Immunotherapy-Associated Diabetes Mellitus: A Retrospective Cohort Study. Cancers (Basel). 2024 Apr 25; 16(9).
Duvalyan E, Brondfield S, Rushakoff RJ, Anderson MS, Quandt Z. PMID: 38730614; PMCID: PMC11083325.
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Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency. J Exp Med. 2024 Jun 03; 221(6).
Johnson MB, Ogishi M, Domingo-Vila C, De Franco E, Wakeling MN, Imane Z, Resnick B, Williams E, Galão RP, Caswell R, Russ-Silsby J, Seeleuthner Y, Rinchai D, Fagniez I, Benson B, Dufort MJ, Speake C, Smithmyer ME, Hudson M, Dobbs R, EXE-T1D consortium, Quandt Z, Hattersley AT, Zhang P, Boisson-Dupuis S, Anderson MS, Casanova JL, Tree TI, Oram RA. PMID: 38634869; PMCID: PMC11032109.
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1 Fields:
Translation:
Humans
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Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis. Nat Commun. 2024 Mar 26; 15(1):2568.
Middha P, Thummalapalli R, Betti MJ, Yao L, Quandt Z, Balaratnam K, Bejan CA, Cardenas E, Falcon CJ, Faleck DM, Princess Margaret Lung Group, Gubens MA, Huntsman S, Johnson DB, Kachuri L, Khan K, Li M, Lovly CM, Murray MH, Patel D, Werking K, Xu Y, Zhan LJ, Balko JM, Liu G, Aldrich MC, Schoenfeld AJ, Ziv E. PMID: 38531883; PMCID: PMC10966072.
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4 Fields:
Translation:
Humans
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Abstract 3460: Predicting cessation of immune checkpoint inhibitor therapy due to severe adverse events with an integrated autoimmune disease polygenic risk score. Cancer Research. 2024 Mar 22; 84(6_Supplement):3460-3460.
Middha MP, Thummalapalli TR, Quandt QZ, Group GP, Gubens GM, Lovly LC, Liu LG, Aldrich AM, Schoenfeld SA, Ziv ZE. .
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Managing hyperglycemia and rash associated with alpelisib: expert consensus recommendations using the Delphi technique. NPJ Breast Cancer. 2024 Jan 31; 10(1):12.
Gallagher EJ, Moore H, Lacouture ME, Dent SF, Farooki A, Goncalves MD, Isaacs C, Johnston A, Juric D, Quandt Z, Spring L, Berman B, Decker M, Hortobagyi GN, Kaffenberger BH, Kwong BY, Pluard T, Rao R, Schwartzberg L, Broder MS. PMID: 38297009; PMCID: PMC10831089.
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2
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Safety and efficacy of immune checkpoint inhibitor cancer therapy in patients with preexisting type 1 diabetes mellitus. Front Endocrinol (Lausanne). 2023; 14:1242830.
Hilder R, Tsai K, Quandt Z, Isaacs D, Drakaki A, Xing Y, In GK, Angell TE, Lechner MG. PMID: 38027216; PMCID: PMC10643762.
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2 Fields:
Translation:
Humans
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Evaluating Survival After Hospitalization Due to Immune-Related Adverse Events From Checkpoint Inhibitors. Oncologist. 2023 10 03; 28(10):e950-e959.
Silverstein J, Wright F, Wang M, Young A, Kim D, De Dios K, Brondfield S, Quandt Z. PMID: 37335906; PMCID: PMC10546826.
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4 Fields:
Translation:
Humans
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Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis. medRxiv. 2023 Sep 13.
Middha P, Thummalapalli R, Betti MJ, Yao L, Quandt Z, Balaratnam K, Bejan CA, Cardenas E, Falcon CJ, Faleck DM, Princess Margaret Lung Group, Gubens MA, Huntsman S, Johnson DB, Kachuri L, Khan K, Li M, Lovly CM, Murray MH, Patel D, Werking K, Xu Y, Zhan LJ, Balko JM, Liu G, Aldrich MC, Schoenfeld AJ, Ziv E. PMID: 37292751; PMCID: PMC10246037.
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Editorial: Immune checkpoint inhibitors in cancer: balancing the benefits with the side effects? Front Endocrinol (Lausanne). 2023; 14:1268402.
Gomes-Lima CJ, Zhou W, Quandt Z. PMID: 37766679; PMCID: PMC10520552.
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Translation:
Humans
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Signal detection in real-world data and confirmation in clinical trials: Diabetes as a case study for a conversation worth having. Cancer. 2023 09 15; 129(18):2769-2770.
Sharon E, Othus M, Quandt ZE. PMID: 37439269; PMCID: PMC11060182.
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Translation:
Humans
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The cognitive load of inpatient consults involving immune-related adverse events. Journal of Clinical Oncology. 2023 Jun 1; 41(16_suppl):11033-11033.
Brondfield BS, Silverstein SJ, de Dios dK, Quandt QZ. .
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Delayed immune toxicities in patients with breast cancer receiving immune checkpoint inhibitors. Journal of Clinical Oncology. 2023 Jun 1; 41(16_suppl):e24091-e24091.
Jacob JS, Quandt QZ, Melisko MM, Majure MM, Chien CA, Blaes BA, Heditsian HD, Esserman EL, Rugo RH. .
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Spectrum of Clinical Presentations, Imaging Findings, and HLA Types in Immune Checkpoint Inhibitor-Induced Hypophysitis. J Endocr Soc. 2023 Feb 09; 7(4):bvad012.
Quandt Z, Kim S, Villanueva-Meyer J, Coupe C, Young A, Kang JH, Yazdany J, Schmajuk G, Rush S, Ziv E, Perdigoto AL, Herold K, Lechner MG, Su MA, Tyrrell JB, Bluestone J, Anderson M, Masharani U. PMID: 36860908; PMCID: PMC9969737.
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8
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Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression. Nat Biotechnol. 2023 05; 41(5):717-727.
Gravina A, Tediashvili G, Rajalingam R, Quandt Z, Deisenroth C, Schrepfer S, Deuse T. PMID: 36593395; PMCID: PMC10188358.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy. Diabetes. 2023 01 01; 72(1):59-70.
Mandel-Brehm C, Vazquez SE, Liverman C, Cheng M, Quandt Z, Kung AF, Parent A, Miao B, Disse E, Cugnet-Anceau C, Dalle S, Orlova E, Frolova E, Alba D, Michels A, Oftedal BE, Lionakis MS, Husebye ES, Agarwal AK, Li X, Zhu C, Li Q, Oral E, Brown R, Anderson MS, Garg A, DeRisi JL. PMID: 35709010; PMCID: PMC9797316.
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11 Fields:
Translation:
HumansAnimals
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Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq. Elife. 2022 10 27; 11.
Vazquez SE, Mann SA, Bodansky A, Kung AF, Quandt Z, Ferré EMN, Landegren N, Eriksson D, Bastard P, Zhang SY, Liu J, Mitchell A, Proekt I, Yu D, Mandel-Brehm C, Wang CY, Miao B, Sowa G, Zorn K, Chan AY, Tagi VM, Shimizu C, Tremoulet A, Lynch K, Wilson MR, Kämpe O, Dobbs K, Delmonte OM, Bacchetta R, Notarangelo LD, Burns JC, Casanova JL, Lionakis MS, Torgerson TR, Anderson MS, DeRisi JL. PMID: 36300623; PMCID: PMC9711525.
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PubMed Mentions:
20 Fields:
Translation:
HumansCells
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Expert consensus recommendations for managing hyperglycemia and rash in patients with PIK3CA-mutated, hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) advanced breast cancer (ABC) treated with alpelisib (ALP). Journal of Clinical Oncology. 2022 Sep 30; 40(28_suppl):422-422.
Gallagher GE, Moore MH, Lacouture LM, Dent DS, Farooki FA, Goncalves GM, Isaacs IC, Johnston JA, Juric JD, Quandt QZ, Spring SL, Berman BB, Decker DM, Hortobagyi HG, Kaffenberger KB, Kwong KB, Pluard PT, Rao RR, Schwartzberg SL, Broder BM. .
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Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor-induced diabetes. JCI Insight. 2022 09 08; 7(17).
Perdigoto AL, Deng S, Du KC, Kuchroo M, Burkhardt DB, Tong A, Israel G, Robert ME, Weisberg SP, Kirkiles-Smith N, Stamatouli AM, Kluger HM, Quandt Z, Young A, Yang ML, Mamula MJ, Pober JS, Anderson MS, Krishnaswamy S, Herold KC. PMID: 35925682; PMCID: PMC9536276.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimals
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Immune checkpoint inhibitor–induced diabetes mellitus across NCI trials. Journal of Clinical Oncology. 2022 Jun 1; 40(16_suppl):2668-2668.
Quandt QZ, Hill HV, Dib DJ, Burian BJ, Tessler TS, Naqash NA, Anderson AM, Othus OM, Sharon SE. .
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189-OR: Immune-Profiling of Pancreatic Tissue Affected by Immune Checkpoint Inhibitor–Induced Diabetes (CPI-D). Diabetes. 2022 Jun 1; 71(Supplement_1).
QUANDT QZ, YOUNG YA, BARLOW BG, DONG DS, SMITH SJ, KUSMARTSEVA KI, BRUSKO BT, COOPER CS, ANDERSON AM. .
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Evaluating survival following severe immune-related adverse events requiring hospitalization. Journal of Clinical Oncology. 2022 Jun 1; 40(16_suppl):2666-2666.
Wright WF, Kim KD, Silverstein SJ, Wang WM, de Dios dK, Young YA, Quandt QZ, Brondfield BS. .
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Autoantibody discovery across monogenic, acquired, and COVID19-associated autoimmunity with scalable PhIP-Seq. bioRxiv. 2022 Mar 24.
Vazquez SE, Mann SA, Bodansky A, Kung AF, Quandt Z, Ferré EMN, Landegren N, Eriksson D, Bastard P, Zhang SY, Liu J, Mitchell A, Mandel-Brehm C, Miao B, Sowa G, Zorn K, Chan AY, Shimizu C, Tremoulet A, Lynch K, Wilson MR, Kampe O, Dobbs K, Delmonte OM, Notarangelo LD, Burns JC, Casanova JL, Lionakis MS, Torgerson TR, Anderson MS, DeRisi JL. PMID: 35350199; PMCID: PMC8963698.
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Patient-Centered Diabetes Care of Cancer Patients. Curr Diab Rep. 2021 12 13; 21(12):62.
Kotwal A, Cheung YM, Cromwell G, Drincic A, Leblebjian H, Quandt Z, Rushakoff RJ, McDonnell ME. PMID: 34902069.
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4 Fields:
Translation:
Humans
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Immunotherapy-Mediated Thyroid Dysfunction: Genetic Risk and Impact on Outcomes with PD-1 Blockade in Non-Small Cell Lung Cancer. Clin Cancer Res. 2021 09 15; 27(18):5131-5140.
Luo J, Martucci VL, Quandt Z, Groha S, Murray MH, Lovly CM, Rizvi H, Egger JV, Plodkowski AJ, Abu-Akeel M, Schulze I, Merghoub T, Cardenas E, Huntsman S, Li M, Hu D, Gubens MA, Gusev A, Aldrich MC, Hellmann MD, Ziv E. PMID: 34244291; PMCID: PMC8815444.
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32 Fields:
Translation:
Humans
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Case 20: Partial ß-Cell Destruction: An Atypical Case of Immune Checkpoint Inhibitor Diabetes. . 2021 Jan 1; 80-82.
Quandt QZ, Mehta MP, Tsai TK, Hsiao HV, Rushakoff RR. .
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Case 21: Checkpoint Inhibitor–Induced Diabetes. . 2021 Jan 1; 83-85.
Mehta MP, Quandt QZ, Rushakoff RR. .
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Autoimmune Endocrinopathies: An Emerging Complication of Immune Checkpoint Inhibitors. Annu Rev Med. 2021 01 27; 72:313-330.
Quandt Z, Young A, Perdigoto AL, Herold KC, Anderson MS. PMID: 32886542.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Breaking β Cell Tolerance After 100 Years of Life: Intratumoral Immunotherapy-Induced Diabetes Mellitus. J Endocr Soc. 2020 Oct 01; 4(10):bvaa114.
Quandt Z, Coupe C, Anderson M, Uihlein A, Young A. PMID: 32964173; PMCID: PMC7491923.
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PubMed Mentions:
1
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Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq. Elife. 2020 05 15; 9.
Vazquez SE, Ferré EM, Scheel DW, Sunshine S, Miao B, Mandel-Brehm C, Quandt Z, Chan AY, Cheng M, German M, Lionakis M, DeRisi JL, Anderson MS. PMID: 32410729; PMCID: PMC7228772.
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PubMed Mentions:
32 Fields:
Translation:
HumansCells
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SUN-298 Spectrum of Imaging in Immune Checkpoint Inhibitor Induced Hypophysitis. Journal of the Endocrine Society. 2020 May 8; 4(Supplement_1):sun-298-.
Quandt QZ, Kim KS, Villanueva-Meyer VJ, Coupe CC, Tyrrell TJ, Bluestone BJ, Anderson AM, Masharani MU. .
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SAT-418 Finding the Needles in the Haystack: Harnessing the Electronic Health Record to Find Thyroid Immune Related Adverse Events. Journal of the Endocrine Society. 2020 May 8; 4(Suppl 1).
Quandt QZ, Trupin TL, Evans EM, Schmajuk SG, Anderson AM, Bluestone BJ, Jinoos JY. .
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SAT-667 Partial Beta-Cell Destruction: An Atypical Case of Immune Checkpoint Inhibitor Diabetes Mellitus. Journal of the Endocrine Society. 2020 May 8; 4(Supplement_1):sat-667-.
Quandt QZ, Tsai TK, Hsiao HV. .
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Immune checkpoint inhibitor diabetes mellitus: a novel form of autoimmune diabetes. Clin Exp Immunol. 2020 05; 200(2):131-140.
Quandt Z, Young A, Anderson M. PMID: 32027018; PMCID: PMC7160652.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimals
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Chapter 19 Thyroid Disorders During Pregnancy, Postpartum, and Lactation. Maternal-Fetal and Neonatal Endocrinology. 2020 Jan 1; 287-315.
Quandt QZ, Salmeen SK, Block-Kurbisch BI. .
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Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma. J Clin Invest. 2019 08 01; 129(11):4676-4681.
Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson MS, Oakes SA. PMID: 31369399; PMCID: PMC6819098.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Checkpoint inhibitor-induced insulin-dependent diabetes: an emerging syndrome. Lancet Diabetes Endocrinol. 2019 06; 7(6):421-423.
Perdigoto AL, Quandt Z, Anderson M, Herold KC. PMID: 30885563.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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The Balancing Act between Cancer Immunity and Autoimmunity in Response to Immunotherapy. Cancer Immunol Res. 2018 12; 6(12):1445-1452.
Young A, Quandt Z, Bluestone JA. PMID: 30510057; PMCID: PMC6281171.
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PubMed Mentions:
78 Fields:
Translation:
HumansAnimals
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Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors. Diabetes. 2018 08; 67(8):1471-1480.
Stamatouli AM, Quandt Z, Perdigoto AL, Clark PL, Kluger H, Weiss SA, Gettinger S, Sznol M, Young A, Rushakoff R, Lee J, Bluestone JA, Anderson M, Herold KC. PMID: 29937434; PMCID: PMC6054443.
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PubMed Mentions:
254 Fields:
Translation:
HumansAnimals
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Phase 2 trial of pembrolizumab (PEM) plus granulocyte macrophage colony stimulating factor (GM-CSF) in advanced biliary cancers (ABC): Clinical outcomes and biomarker analyses. Journal of Clinical Oncology. 2018 May 20; 36(15_suppl):4087-4087.
Kelley KR, Mitchell ME, Behr BS, Hwang HJ, Keenan KB, Umetsu US, Gordan GJ, Ko KA, Cinar CP, Atreya AC, Van Loon VK, Weber WT, Ngo NZ, Quandt QZ, Liu LC, Venook VA, Fong FL. .
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Phase II trial of pembrolizumab (PEM) plus granulocyte macrophage colony stimulating factor (GM-CSF) in advanced biliary cancers (ABC). Journal of Clinical Oncology. 2018 Feb 1; 36(4_suppl):386-386.
Kelley KR, Mitchell ME, Behr BS, Hwang HJ, Keenan KB, Cheung CA, Gordan GJ, Ko KA, Cinar CP, Atreya AC, Van Loon VK, Weber WT, Ngo NZ, Quandt QZ, Liu LC, Venook VA, Fong FL. .
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Spontaneous tumor lysis syndrome in a patient with metastatic prostate cancer. Mol Clin Oncol. 2017 Apr; 6(4):589-592.
Serling-Boyd N, Quandt Z, Allaudeen N. PMID: 28413674; PMCID: PMC5374943.
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PubMed Mentions:
11
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The association of alcohol consumption with mammographic density in a multiethnic urban population. BMC Cancer. 2015; 15:1094.
Quandt Z, Flom JD, Tehranifar P, Reynolds D, Terry MB, McDonald JA. PMID: 25777420; PMCID: PMC4374505.
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PubMed Mentions:
19 Fields:
Translation:
Humans
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Association of age, stature, and education with ocular dimensions in an older white population. Arch Ophthalmol. 2009 Jan; 127(1):88-93.
Lee KE, Klein BE, Klein R, Quandt Z, Wong TY. PMID: 19139346; PMCID: PMC2725427.
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PubMed Mentions:
30 Fields:
Translation:
Humans