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    Fumiko Hoeft, MD, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    Address401 Parnassus Ave, LangPorter
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Education and Training
      Harvard U - NeurophysiologyPredocNeurology2000
      Caltech - Computation & Neural SystemsFellowshipBiology2003
      Stanford U - Developmental Cog NeurosciPostdocPsychology2005
      Keio U (Tokyo) - Medicine & NeurophysiologyMD PhDNeuropsychiatry2003
      Collapse Awards and Honors
      Learning & the Brain Foundation; Int'l, Mind, Brain & Education Society (IMBES)2015Transforming Education through Neuroscience Award
      UNESCO2015UNITWIN Network on Global Literacy
      White House2015OSTP Neuroscience and Learning Workshop
      International Dyslexia Association2014Norman Geschwind Memorial Lectureship
      NICHD2008K23 Career Award
      Lucile Packard Foundation for Children’s Health2008Spectrum Child Health & Clinical and Translational Science Award
      Brain & Behavior Research Foundation2008Young Investigator Award
      Stanford University2008Postdoctoral Mentor Award (Honorary Mention)
      Lucile Packard Foundation for Children’s Health2007Spectrum Child Health & Clinical and Translational Science Award
      Mind Science Foundation2005Tom Slick Research Award in Consciousness
      World Psychiatric Association2002XII World Congress of Psychiatry Award for Outstanding Contribution
      Cellular Science Research Foundation1998Young Investigator Award
      Japan North America Medical Exchange Foundation (JANAMEF)1998Young Investigator Award
      Yoshida Science Promotion Foundation1998Young Investigator Award
      Windward School2016Robert J. Schwartz Memorial Lectureship

      Collapse Overview 
      Collapse Overview
      GENERAL: Fumiko Hoeft MD PhD is Associate Professor of Child & Adolescent Psychiatry, Dyslexia Center, Director of the UCSF Hoeft Laboratory for Educational Neuroscience (, and Scientific Advisor of the Bay Area Discovery Museum’s Center for Childhood Creativity (BADM’s CCC). She received research training at Harvard, UCLA, Caltech and Stanford. Dr. Hoeft’s current research program focuses on brain development, and brain mechanisms underlying skill acquisition such as language and reading, and educationally relevant concepts such as motivation, mindset, grit and stereotype threat. She also has passion for research in dyslexia and autism. Recent honors include the Norman Geschwind Memorial Lectureship from the International Dyslexia Association (IDA), and Transforming Education through Neuroscience from Learning & the Brain Foundation, and International Mind Brain & Education Society (IMBES). She has published over 100 articles in journals such as the Proceedings for the National Academy of Sciences and the Journal of Neuroscience. Hoeft has delivered over 120 lectures including remarks at UNESCO, White House, and keynotes at IMBES. Her work has been covered in media such as The New York Times, NPR, CNN and the New Yorker.

      SCIENTIFIC: I am a developmental and cognitive neuroscientist with clinical training in psychiatry. Broadly speaking, our group examines brain development in children using various neuroimaging techniques such as TMS/tDCS, fNIRS, fMRI, aMRI, DTI/HARDI and MEG. We are interested in identifying how biology (gene) and environment influence the development of language, social and executive brain networks. We are also interested in developing practical (clinical and educational) applications of neuroimaging: for example, 1. by using machine learning methods and neuroimaging, behavioral, cognitive, genetic and environmental measures to predict outcome of interventions, academic achievement and clinical symptoms, 2. by using real-time fMRI (fNIRS) feedback training to enhance cognitive function and reduce symptoms, and 3. by investigating brain mechanisms underlying response to certain interventions and training such as motivation training and reading intervention. We study healthy children and also children with learning disabilities such as developmental dyslexia, and neurodevelopmental disorders such as idiopathic autism.
      Other appointments include: Research Scientist @ Haskins Laboratories at Yale Univ, and Adj Faculty of Neuropsychiatry @ Keio Univ Sch of Med (Japan).

      Collapse Interests
      neuroimaging, cognitive neuroscience, educational neuroscience, dyslexia, autism, motivation, SEL

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Gimenez P, Bugescu N, Black JM, Hancock R, Pugh K, Nagamine M, Kutner E, Mazaika P, Hendren R, McCandliss BD, Hoeft F. Neuroimaging correlates of handwriting quality as children learn to read and write. Front Hum Neurosci. 2014; 8:155.
        View in: PubMed PMC3958698
      2. Pugh KR, Frost SJ, Rothman DL, Hoeft F, Del Tufo SN, Mason GF, Molfese PJ, Mencl WE, Grigorenko EL, Landi N, Preston JL, Jacobsen L, Seidenberg MS, Fulbright RK. Glutamate and choline levels predict individual differences in reading ability in emergent readers. J Neurosci. 2014 Mar 12; 34(11):4082-9.
        View in: PubMed PMC3951703
      3. Hong DS, Hoeft F, Marzelli MJ, Lepage JF, Roeltgen D, Ross J, Reiss AL. Influence of the X-chromosome on neuroanatomy: evidence from Turner and Klinefelter syndromes. J Neurosci. 2014 Mar 5; 34(10):3509-16.
        View in: PubMed PMC3942570
      4. Preston JL, Molfese PJ, Mencl WE, Frost SJ, Hoeft F, Fulbright RK, Landi N, Grigorenko EL, Seki A, Felsenfeld S, Pugh KR. Structural brain differences in school-age children with residual speech sound errors. Brain Lang. 2014 Jan; 128(1):25-33.
        View in: PubMed PMC3926206
      5. Hong DS, Bray S, Haas BW, Hoeft F, Reiss AL. Aberrant neurocognitive processing of fear in young girls with Turner syndrome. Soc Cogn Affect Neurosci. 2014 Mar; 9(3):255-64.
        View in: PubMed PMC3980805
      6. Bray S, Hoeft F, Hong DS, Reiss AL. Aberrant functional network recruitment of posterior parietal cortex in Turner syndrome. Hum Brain Mapp. 2013 Dec; 34(12):3117-28.
        View in: PubMed
      7. Black JM, Tanaka H, Stanley L, Nagamine M, Zakerani N, Thurston A, Kesler S, Hulme C, Lyytinen H, Glover GH, Serrone C, Raman MM, Reiss AL, Hoeft F. Maternal history of reading difficulty is associated with reduced language-related gray matter in beginning readers. Neuroimage. 2012 Feb 1; 59(3):3021-32.
        View in: PubMed PMC3628690
      8. Mimura M, Hoeft F, Kato M, Kobayashi N, Sheau K, Piggot J, Mills D, Galaburda A, Korenberg JR, Bellugi U, Reiss AL. A preliminary study of orbitofrontal activation and hypersociability in Williams Syndrome. J Neurodev Disord. 2010 Jan 26; 2(2):93-98.
        View in: PubMed
      9. Ross J, Hoeft F. Introduction: cognitive profiles in sex chromosome disorders. Dev Disabil Res Rev. 2009; 15(4):269.
        View in: PubMed
      10. Steinman K, Ross J, Lai S, Reiss A, Hoeft F. Structural and functional neuroimaging in Klinefelter (47,XXY) syndrome: a review of the literature and preliminary results from a functional magnetic resonance imaging study of language. Dev Disabil Res Rev. 2009; 15(4):295-308.
        View in: PubMed PMC2876340
      11. Hagan CC, Hoeft F, Mackey A, Mobbs D, Reiss AL. Aberrant neural function during emotion attribution in female subjects with fragile X syndrome. J Am Acad Child Adolesc Psychiatry. 2008 Dec; 47(12):1443-354.
        View in: PubMed
      12. Dankert ME, Brensinger CM, Metzger KL, Li C, Koleva SG, Mesén A, Laprade B, Wiguna T, Han C, Farooq S, Severus WE, Gayares JG, Langosch JM, Lallart X, Tateno M, Mihai A, Nair SR, Belmaker R, Rybakowski J, Owe-Larsson B, Kane JM, Johnstone EC, MacIntyre DJ, Malhotra S, González-Pinto A, Mosquera F, Babb SM, Habib pour E, Fatemi SS, Swanson C, Adler C, Young A, Hoeft F, Sivakumar K, Radoeva PD, Lallart EA, Bilker WB, Siegel SJ. Attitudes of patients and family members towards implantable psychiatric medication. Schizophr Res. 2008 Oct; 105(1-3):279-86.
        View in: PubMed
      13. Reiss AL, Hoeft F, Tenforde AS, Chen W, Mobbs D, Mignot EJ. Anomalous hypothalamic responses to humor in cataplexy. PLoS One. 2008; 3(5):e2225.
        View in: PubMed PMC2377337
      14. Hoeft F, Hernandez A, Parthasarathy S, Watson CL, Hall SS, Reiss AL. Fronto-striatal dysfunction and potential compensatory mechanisms in male adolescents with fragile X syndrome. Hum Brain Mapp. 2007 Jun; 28(6):543-54.
        View in: PubMed
      15. Gothelf D, Hoeft F, Hinard C, Hallmayer JF, Stoecker JV, Antonarakis SE, Morris MA, Reiss AL. Abnormal cortical activation during response inhibition in 22q11.2 deletion syndrome. Hum Brain Mapp. 2007 Jun; 28(6):533-42.
        View in: PubMed
      16. deCharms RC, Maeda F, Glover GH, Ludlow D, Pauly JM, Soneji D, Gabrieli JD, Mackey SC. Control over brain activation and pain learned by using real-time functional MRI. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18626-31.
        View in: PubMed PMC1311906
      17. Maeda F, Kanai R, Shimojo S. Changing pitch induced visual motion illusion. Curr Biol. 2004 Dec 14; 14(23):R990-1.
        View in: PubMed
      18. Mackey SC, Maeda F. Functional imaging and the neural systems of chronic pain. Neurosurg Clin N Am. 2004 Jul; 15(3):269-88.
        View in: PubMed
      19. Maeda F, Pascual-Leone A. Transcranial magnetic stimulation: studying motor neurophysiology of psychiatric disorders. Psychopharmacology (Berl). 2003 Aug; 168(4):359-76.
        View in: PubMed
      20. Heiser M, Iacoboni M, Maeda F, Marcus J, Mazziotta JC. The essential role of Broca's area in imitation. Eur J Neurosci. 2003 Mar; 17(5):1123-8.
        View in: PubMed
      21. Aziz-Zadeh L, Maeda F, Zaidel E, Mazziotta J, Iacoboni M. Lateralization in motor facilitation during action observation: a TMS study. Exp Brain Res. 2002 May; 144(1):127-31.
        View in: PubMed
      22. Maeda F, Gangitano M, Thall M, Pascual-Leone A. Inter- and intra-individual variability of paired-pulse curves with transcranial magnetic stimulation (TMS). Clin Neurophysiol. 2002 Mar; 113(3):376-82.
        View in: PubMed
      23. Maeda F, Kleiner-Fisman G, Pascual-Leone A. Motor facilitation while observing hand actions: specificity of the effect and role of observer's orientation. J Neurophysiol. 2002 Mar; 87(3):1329-35.
        View in: PubMed
      24. Robertson EM, Tormos JM, Maeda F, Pascual-Leone A. The role of the dorsolateral prefrontal cortex during sequence learning is specific for spatial information. Cereb Cortex. 2001 Jul; 11(7):628-35.
        View in: PubMed
      25. Maeda F, Keenan JP, Tormos JM, Topka H, Pascual-Leone A. Interindividual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability. Exp Brain Res. 2000 Aug; 133(4):425-30.
        View in: PubMed
      26. Maeda F, Keenan JP, Pascual-Leone A. Interhemispheric asymmetry of motor cortical excitability in major depression as measured by transcranial magnetic stimulation. Br J Psychiatry. 2000 Aug; 177:169-73.
        View in: PubMed
      27. Maeda F, Keenan JP, Tormos JM, Topka H, Pascual-Leone A. Modulation of corticospinal excitability by repetitive transcranial magnetic stimulation. Clin Neurophysiol. 2000 May; 111(5):800-5.
        View in: PubMed
      28. Maeda F, Nathan JH. Understanding taijin kyofusho through its treatment, Morita therapy. J Psychosom Res. 1999 Jun; 46(6):525-30.
        View in: PubMed
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