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Robert Hendren, DO

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentPsychiatry
Address401 Parnassus Ave, LangPorter
San Francisco CA 94143
Phone415-476-7044
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    Collapse Overview 
    Collapse Overview
    Robert L. Hendren, D.O., is Professor of Psychiatry and Behavioral Science; Division of Child and Adolescent Psychiatry; Co-Director of the UCSF Dyslexia Center; and Director, Neurodevelopmental, Translational Outcomes Research Program (NTORP). He works in the STAR Autism and Neurodevelopmental Disorders Program. Dr. Hendren is Past President of the American Academy of Child and Adolescent Psychiatry (2007-2009). He has published over 100 scientific papers and 5 books and has been listed in “The Best Doctors in America”, each year since it was first published in 1996.

    Dr. Hendren took his residency in general psychiatry at the Mayo Graduate School of Medicine, and his child and adolescent psychiatry fellowship at the Yale Child Study Center. He is board certified in General as well as Child and Adolescent Psychiatry. He has been on the faculty at the George Washington University School of Medicine, the University of New Mexico School of Medicine, and the University of Medicine and Dentistry of New Jersey (now Rutger’s) - Robert Wood Johnson and New Jersey Medical Schools. From 2001-2009, he was Professor of Psychiatry and Executive Director and Tsakopoulos-Vismara Chair at the University of California, Davis M.I.N.D. Institute (Medical Investigation of Neurodevelopmental Disorders).

    His current areas of research and publication interests are translational interventional outcomes research including clinical pharmacology, nutraceutical and nutritional trials using biomarkers (MRI, measures of inflammation, oxidative stress, immune function and pharmacogenomics) to enhance resilience in neurodevelopmental disorders. He is currently applying a targeted outcomes research approach in a collaborative projects with the Oak Hill School for youth with severe autism and neurodevelopmental spectrum disorders in San Anselmo, CA and at the Charles Armstrong School for youth with dyslexia in Belmont, CA.


    Collapse Research 
    Collapse Research Activities and Funding
    Pharmacogenomics in Autism Treatment
    NIH/NIMH R21MH080026Feb 1, 2008 - Jan 31, 2011
    Role: Principal Investigator
    NEUROPSYCHOPHYSIOLOGIC STUDY-SEVERELY DISTURBED CHILDREN
    NIH/NIMH R01MH045838Apr 1, 1991 - Mar 31, 1995
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bent S, Lawton B, Warren T, Widjaja F, Dang K, Fahey JW, Cornblatt B, Kinchen JM, Delucchi K, Hendren R. Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Mol Autism. 2018; 9:35. PMID: 29854372.
      View in: PubMed
    2. Hendren R, Haft SL, Black JM, White NC, Hoeft F. Recognizing Psychiatric Comorbidity With Reading Disorders. Front Psychiatry. 2018; 9:101. PMID: 29636707.
      View in: PubMed
    3. Caverzasi E, Mandelli ML, Hoeft F, Watson C, Meyer M, Allen IE, Papinutto N, Wang C, Gandini Wheeler-Kingshott CAM, Marco EJ, Mukherjee P, Miller ZA, Miller BL, Hendren R, Shapiro KA, Gorno-Tempini ML. Abnormal age-related cortical folding and neurite morphology in children with developmental dyslexia. Neuroimage Clin. 2018; 18:814-821. PMID: 29876267.
      View in: PubMed
    4. Dang K, Bent S, Lawton B, Warren T, Widjaja F, McDonald MG, Breard M, O'Keefe W, Hendren R. Integrating Autism Care through a School-Based Intervention Model: A Pilot Study. J Clin Med. 2017 Oct 19; 6(10). PMID: 29048365.
      View in: PubMed
    5. Ness SL, Manyakov NV, Bangerter A, Lewin D, Jagannatha S, Boice M, Skalkin A, Dawson G, Janvier YM, Goodwin MS, Hendren R, Leventhal B, Shic F, Cioccia W, Pandina G. JAKE® Multimodal Data Capture System: Insights from an Observational Study of Autism Spectrum Disorder. Front Neurosci. 2017; 11:517. PMID: 29018317.
      View in: PubMed
    6. Mitra I, Tsang K, Ladd-Acosta C, Croen LA, Aldinger KA, Hendren R, Traglia M, Lavillaureix A, Zaitlen N, Oldham MC, Levitt P, Nelson S, Amaral DG, Hertz-Picciotto I, Fallin MD, Weiss LA. Correction: Pleiotropic Mechanisms Indicated for Sex Differences in Autism. PLoS Genet. 2017 06; 13(6):e1006831. PMID: 28591140.
      View in: PubMed
    7. Bangerter A, Ness S, Aman MG, Esbensen AJ, Goodwin MS, Dawson G, Hendren R, Leventhal B, Khan A, Opler M, Harris A, Pandina G. Autism Behavior Inventory: A Novel Tool for Assessing Core and Associated Symptoms of Autism Spectrum Disorder. J Child Adolesc Psychopharmacol. 2017 Nov; 27(9):814-822. PMID: 28498053.
      View in: PubMed
    8. Bent S, Ailarov A, Dang KT, Widjaja F, Lawton BL, Hendren R. Open-Label Trial of Vitamin D3 Supplementation in Children with Autism Spectrum Disorder. J Altern Complement Med. 2017 May; 23(5):394-395. PMID: 28437142.
      View in: PubMed
    9. Bent S, Dang K, Widjaja F, Lawton B, Nazneen N, Hendren R. Examining Clinics for Children with Autism: The Autism Translating To Treatment Study. J Altern Complement Med. 2017 May; 23(5):340-347. PMID: 28084799.
      View in: PubMed
    10. Mitra I, Tsang K, Ladd-Acosta C, Croen LA, Aldinger KA, Hendren R, Traglia M, Lavillaureix A, Zaitlen N, Oldham MC, Levitt P, Nelson S, Amaral DG, Hertz-Picciotto I, Fallin MD, Weiss LA. Pleiotropic Mechanisms Indicated for Sex Differences in Autism. PLoS Genet. 2016 11; 12(11):e1006425. PMID: 27846226.
      View in: PubMed
    11. Aman MG, Findling RL, Hardan AY, Hendren R, Melmed RD, Kehinde-Nelson O, Hsu HA, Trugman JM, Palmer RH, Graham SM, Gage AT, Perhach JL, Katz E. Safety and Efficacy of Memantine in Children with Autism: Randomized, Placebo-Controlled Study and Open-Label Extension. J Child Adolesc Psychopharmacol. 2017 Jun; 27(5):403-412. PMID: 26978327.
      View in: PubMed
    12. Hendren R, James SJ, Widjaja F, Lawton B, Rosenblatt A, Bent S. Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism. J Child Adolesc Psychopharmacol. 2016 Nov; 26(9):774-783. PMID: 26889605.
      View in: PubMed
    13. Besterman AD, Hendren R. Psychopharmacological Management of Problem Behaviors in Mowat-Wilson Syndrome. J Child Adolesc Psychopharmacol. 2015 Oct; 25(8):656-7. PMID: 26402313; PMCID: PMC4615772 [Available on 10/01/16].
    14. Bent S, Hendren R. Complementary and alternative treatments for autism part 1: evidence-supported treatments. AMA J Ethics. 2015 Apr 01; 17(4):369-74. PMID: 25901707.
      View in: PubMed
    15. Choi JE, Widjaja F, Careaga M, Bent S, Ashwood P, Hendren R. Change in plasma cytokine levels during risperidone treatment in children with autism. J Child Adolesc Psychopharmacol. 2014 Dec; 24(10):586-9. PMID: 24828014.
      View in: PubMed
    16. Myers CA, Vandermosten M, Farris EA, Hancock R, Gimenez P, Black JM, Casto B, Drahos M, Tumber M, Hendren R, Hulme C, Hoeft F. White matter morphometric changes uniquely predict children's reading acquisition. Psychol Sci. 2014 Oct; 25(10):1870-83. PMID: 25212581; PMCID: PMC4326021.
    17. Goldani AA, Downs SR, Widjaja F, Lawton B, Hendren R. Biomarkers in autism. Front Psychiatry. 2014; 5:100. PMID: 25161627; PMCID: PMC4129499.
    18. Gimenez P, Bugescu N, Black JM, Hancock R, Pugh K, Nagamine M, Kutner E, Mazaika P, Hendren R, McCandliss BD, Hoeft F. Neuroimaging correlates of handwriting quality as children learn to read and write. Front Hum Neurosci. 2014; 8:155. PMID: 24678293; PMCID: PMC3958698.
    19. Bent S, Hendren R, Zandi T, Law K, Choi JE, Widjaja F, Kalb L, Nestle J, Law P. Internet-based, randomized, controlled trial of omega-3 fatty acids for hyperactivity in autism. J Am Acad Child Adolesc Psychiatry. 2014 Jun; 53(6):658-66. PMID: 24839884; PMCID: PMC4076340.
    20. Adviento B, Corbin IL, Widjaja F, Desachy G, Enrique N, Rosser T, Risi S, Marco EJ, Hendren R, Bearden CE, Rauen KA, Weiss LA. Autism traits in the RASopathies. J Med Genet. 2014 Jan; 51(1):10-20. PMID: 24101678; PMCID: PMC4230531.
    21. McBurnett K, Swetye M, Muhr H, Hendren R. Pharmacotherapy of inattention and ADHD in adolescents. Adolesc Med State Art Rev. 2013 Aug; 24(2):391-405, viii. PMID: 24298754.
      View in: PubMed
    22. Hendren R, Reeve A. Preface. Adolescent psychopharmacology update. Adolesc Med State Art Rev. 2013 Aug; 24(2):xi-xiii. PMID: 24298751.
      View in: PubMed
    23. Cheng JX, Widjaja F, Choi JE, Hendren R. Considering biomedical/CAM treatments. Adolesc Med State Art Rev. 2013 Aug; 24(2):446-64, x. PMID: 24298758.
      View in: PubMed
    24. Connolly CG, Wu J, Ho TC, Hoeft F, Wolkowitz O, Eisendrath S, Frank G, Hendren R, Max JE, Paulus MP, Tapert SF, Banerjee D, Simmons AN, Yang TT. Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents. Biol Psychiatry. 2013 Dec 15; 74(12):898-907. PMID: 23910949; PMCID: PMC4103629.
    25. Ho TC, Wu J, Shin DD, Liu TT, Tapert SF, Yang G, Connolly CG, Frank GK, Max JE, Wolkowitz O, Eisendrath S, Hoeft F, Banerjee D, Hood K, Hendren R, Paulus MP, Simmons AN, Yang TT. Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression. J Am Acad Child Adolesc Psychiatry. 2013 Oct; 52(10):1076-1091.e2. PMID: 24074474; PMCID: PMC3825460.
    26. Hendren R. Autism: biomedical complementary treatment approaches. Child Adolesc Psychiatr Clin N Am. 2013 Jul; 22(3):443-56, vi. PMID: 23806313.
      View in: PubMed
    27. Xie Y, Dixon JF, Yee OM, Zhang J, Chen YA, Deangelo S, Yellowlees P, Hendren R, Schweitzer JB. A study on the effectiveness of videoconferencing on teaching parent training skills to parents of children with ADHD. Telemed J E Health. 2013 Mar; 19(3):192-9. PMID: 23405952.
      View in: PubMed
    28. Lofthouse N, Hendren R, Hurt E, Arnold LE, Butter E. A review of complementary and alternative treatments for autism spectrum disorders. Autism Res Treat. 2012; 2012:870391. PMID: 23243505; PMCID: PMC3515887.
    29. Bent S, Bertoglio K, Ashwood P, Nemeth E, Hendren R. Brief report: Hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorder: a clinical trial. J Autism Dev Disord. 2012 Jun; 42(6):1127-32. PMID: 21818676.
      View in: PubMed
    30. Bent S, Bertoglio K, Ashwood P, Bostrom A, Hendren R. A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder. J Autism Dev Disord. 2011 May; 41(5):545-54. PMID: 20683766.
      View in: PubMed
    31. Hagerman RJ, Hendren R. Shifting the paradigm for autism treatments. Neurotherapeutics. 2010 Jul; 7(3):230-1. PMID: 20643374; PMCID: PMC4043294.
    32. Bent S, Hendren R. Improving the prediction of response to therapy in autism. Neurotherapeutics. 2010 Jul; 7(3):232-40. PMID: 20643375.
      View in: PubMed
    33. Bertoglio K, Jill James S, Deprey L, Brule N, Hendren R. Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism. J Altern Complement Med. 2010 May; 16(5):555-60. PMID: 20804367.
      View in: PubMed
    34. Stoddard J, Niendam T, Hendren R, Carter C, Simon TJ. Attenuated positive symptoms of psychosis in adolescents with chromosome 22q11.2 deletion syndrome. Schizophr Res. 2010 May; 118(1-3):118-21. PMID: 20056393; PMCID: PMC2856801.
    35. Hendren R, Bertoglio K, Ashwood P, Sharp F. Mechanistic biomarkers for autism treatment. Med Hypotheses. 2009 Dec; 73(6):950-4. PMID: 19619951.
      View in: PubMed
    36. Hilty DM, Yellowlees PM, Sonik P, Derlet M, Hendren R. Rural child and adolescent telepsychiatry: successes and struggles. Pediatr Ann. 2009 Apr; 38(4):228-32. PMID: 19455953.
      View in: PubMed
    37. Bent S, Bertoglio K, Hendren R. Omega-3 fatty acids for autistic spectrum disorder: a systematic review. J Autism Dev Disord. 2009 Aug; 39(8):1145-54. PMID: 19333748.
      View in: PubMed
    38. Corbett BA, Constantine LJ, Hendren R, Rocke D, Ozonoff S. Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development. Psychiatry Res. 2009 Apr 30; 166(2-3):210-22. PMID: 19285351; PMCID: PMC2683039.
    39. McCarthy M, Hendren R. Autism spectrum disorders have increased dramatically in prevalence in recent years. Preface. Psychiatr Clin North Am. 2009 Mar; 32(1):xiii-xv. PMID: 19248912.
      View in: PubMed
    40. Solomon M, Hessl D, Chiu S, Olsen E, Hendren R. Towards a neurodevelopmental model of clinical case formulation. Psychiatr Clin North Am. 2009 Mar; 32(1):199-211. PMID: 19248925; PMCID: PMC2692218.
    41. Bertoglio K, Hendren R. New developments in autism. Psychiatr Clin North Am. 2009 Mar; 32(1):1-14. PMID: 19248913.
      View in: PubMed
    42. Bent S, Bertoglio K, Hendren R. Regarding omega-3 fatty acids in severe autism. Arch Med Res. 2009 Jan; 40(1):64; author reply 65. PMID: 19064131.
      View in: PubMed
    43. Martin A, Hendren R, Greenhill LL, Bird HR. Hats off: journal awards. J Am Acad Child Adolesc Psychiatry. 2008 Dec; 47(12):1484-5. PMID: 19034192.
      View in: PubMed
    44. Hendren R. Casting a wide net to nurture mentally healthy children. J Am Acad Child Adolesc Psychiatry. 2008 Feb; 47(2):123-8. PMID: 18216713.
      View in: PubMed
    45. Chiu S, Widjaja F, Bates ME, Voelbel GT, Pandina G, Marble J, Blank JA, Day J, Brule N, Hendren R. Anterior cingulate volume in pediatric bipolar disorder and autism. J Affect Disord. 2008 Jan; 105(1-3):93-9. PMID: 17568686.
      View in: PubMed
    46. Sharp FR, Hendren R. Psychosis: atypical limbic epilepsy versus limbic hyperexcitability with onset at puberty? Epilepsy Behav. 2007 Jun; 10(4):515-20. PMID: 17416210; PMCID: PMC2680611.
    47. Solomon M, Hessl D, Chiu S, Hagerman R, Hendren R. A genetic etiology of pervasive developmental disorder guides treatment. Am J Psychiatry. 2007 Apr; 164(4):575-80. PMID: 17403969.
      View in: PubMed
    48. Voelbel GT, Bates ME, Buckman JF, Pandina G, Hendren R. Caudate nucleus volume and cognitive performance: Are they related in childhood psychopathology? Biol Psychiatry. 2006 Nov 01; 60(9):942-50. PMID: 16950212; PMCID: PMC2947855.
    49. Sugden SG, Kile SJ, Hendren R. Neurodevelopmental pathways to aggression: a model to understand and target treatment in youth. J Neuropsychiatry Clin Neurosci. 2006; 18(3):302-17. PMID: 16963580.
      View in: PubMed
    50. Horst RO, Hendren R. Integrated pharmacologic treatment of attention-deficit hyperactivity disorder (ADHD). Essent Psychopharmacol. 2005; 6(5):250-61. PMID: 16222910.
      View in: PubMed
    51. Hendren R. Discussion on integrated pharmacologic treatment of attention-deficit hyperactivity disorder (ADHD). Essent Psychopharmacol. 2005; 6(5):291-300. PMID: 16222913.
      View in: PubMed
    52. Hanft A, Hendren R. Pharmacotherapy of children and adolescents with pervasive developmental disorders. Essent Psychopharmacol. 2004; 6(1):12-24. PMID: 15612651.
      View in: PubMed
    53. Hendren R, De Backer I, Pandina GJ. Review of neuroimaging studies of child and adolescent psychiatric disorders from the past 10 years. J Am Acad Child Adolesc Psychiatry. 2000 Jul; 39(7):815-28. PMID: 10892223.
      View in: PubMed
    54. Brooks WM, Hodde-Vargas J, Vargas LA, Yeo RA, Ford CC, Hendren R. Frontal lobe of children with schizophrenia spectrum disorders: a proton magnetic resonance spectroscopic study. Biol Psychiatry. 1998 Feb 15; 43(4):263-9. PMID: 9513735.
      View in: PubMed
    55. Yeo RA, Hodde-Vargas J, Hendren R, Vargas LA, Brooks WM, Ford CC, Gangestad SW, Hart BL. Brain abnormalities in schizophrenia-spectrum children: implications for a neurodevelopmental perspective. Psychiatry Res. 1997 Nov 28; 76(1):1-13. PMID: 9498305.
      View in: PubMed
    56. Bailey RA, Hendren R. A Primer on Adolescent Psychopharmacology. Adolesc Med. 1997 Feb; 8(1):33-55. PMID: 10360007.
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    57. Hendren R, Hodde-Vargas J, Yeo RA, Vargas LA, Brooks WM, Ford C. Neuropsychophysiological study of children at risk for schizophrenia: a preliminary report. J Am Acad Child Adolesc Psychiatry. 1995 Oct; 34(10):1284-91. PMID: 7592265.
      View in: PubMed
    58. Hendren R. Adolescent psychotherapy research: a practical review. Am J Psychother. 1993; 47(3):334-43. PMID: 8214212.
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    59. Geraty RD, Hendren R, Flaa CJ. Ethical perspectives on managed care as it relates to child and adolescent psychiatry. J Am Acad Child Adolesc Psychiatry. 1992 May; 31(3):398-402. PMID: 1592769.
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    60. Davis G, Hendren R. What Pediatricians Should Know About Adolescent Psychiatry. Adolesc Med. 1992 Feb; 3(1):131-146. PMID: 10356171.
      View in: PubMed
    61. Hendren R. Brain imaging and neurodevelopmental psychiatry. West J Med. 1991 Nov; 155(5):522-3. PMID: 1815401; PMCID: PMC1003075.
    62. Hendren R, Hodde-Vargas JE, Vargas LA, Orrison WW, Dell L. Magnetic resonance imaging of severely disturbed children--a preliminary study. J Am Acad Child Adolesc Psychiatry. 1991 May; 30(3):466-70. PMID: 2055885.
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    63. Hendren R, Taylor WS, Lemke BJ, Lemke PA. An autistic boy copes with a terminal illness. J Am Acad Child Adolesc Psychiatry. 1990 Nov; 29(6):901-4. PMID: 2273018.
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    64. Hendren R, Sholevar GP, Weinberger DR, Wiener JM. Schizophrenia in a fourteen-year-old boy. J Am Acad Child Adolesc Psychiatry. 1990 Jan; 29(1):141-8. PMID: 2295568.
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    65. Hendren R, Atkins DM, Sumner CR, Barber JK. Model for the group treatment of eating disorders. Int J Group Psychother. 1987 Oct; 37(4):589-602. PMID: 3679642.
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    66. Hendren R, Barber JK, Sigafoos A. Eating-disordered symptoms in a nonclinical population: a study of female adolescents in two private schools. J Am Acad Child Psychiatry. 1986 Nov; 25(6):836-40. PMID: 3794126.
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    67. Wiener JM, Hendren R. Childhood depression. J Dev Behav Pediatr. 1983 Mar; 4(1):43-9. PMID: 6833504.
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    68. Hendren R. Depression in anorexia nervosa. J Am Acad Child Psychiatry. 1983 Jan; 22(1):59-62. PMID: 6826999.
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    69. Kuhnley EJ, Hendren R, Quinlan DM. Fire-setting by children. J Am Acad Child Psychiatry. 1982 Nov; 21(6):560-3. PMID: 7175051.
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