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Stephen Bent, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-221-4810
ORCID ORCID Icon0000-0002-4767-9714 Additional info
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    Collapse Biography 
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    University of California, San FranciscoResidency School of Medicine - Internal Medicine
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training

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    Dr. Bent's main research interest is the evaluation of the safety and efficacy of herbal remedies and dietary supplements. He served as the project director for one of the first large randomized controlled trials of saw palmetto for enlarged prostate, which gained international recognition for demonstrating that this commonly used herb was no more effective than placebo. Dr. Bent has also served as the principal investigator or co-investigator of several other large randomized controlled trials, including a study of a Chinese herbal remedy used to treat fatigue in the elderly and an internet-based study examining the efficacy of the herbs valerian (for sleep) and kava (for anxiety). Recently, Dr. Bent has conducted clinical trials of complementary and alternative therapies in children with autism, including studies of omega-3 fatty acids, methyl B12, sulforaphane, and vitamin D. Dr. Bent was also the Principal Investigator of the first-ever fully internet-based randomized controlled trial of a pharmaceutical drug and the first internet-based trial of a treatment (omega-3 fatty acids) conducted in children with autism. He plans to further develop internet-based technology to speed the testing of promising new therapies. Dr. Bent is an expert in evidence-based medicine and ambulatory care, and has coauthored textbooks in both areas.

    Collapse Research 
    Collapse Research Activities and Funding
    Early Identification of Adverse Reactions to Herbs
    NIH/NCCIH K08AT001338Dec 16, 2002 - Nov 30, 2008
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Implementing an established musculoskeletal educational curriculum in a new context: a study of effectiveness and feasibility. Med Educ Online. 2020 Dec; 25(1):1760466. Pearson M, Barker AM, Battistone MJ, Bent S, Odden K, O'Brien B. PMID: 32379582.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Optimal management of esophageal cancer in Africa: A systemic review of treatment strategies. Int J Cancer. 2020 Sep 15. Buckle GC, Mahapatra R, Mwachiro M, Akoko L, Mmbaga EJ, White RE, Bent S, Van Loon K. PMID: 32930395.
      View in: PubMed   Mentions:    Fields:    
    3. Quality of Life Among School-Age Children With Autism: The Oak Hill School Outcomes Study. Semin Pediatr Neurol. 2020 Jul; 34:100808. Bent S, Wahlberg J, Chen Y, Widjaja F, McDonald MG, Hendren RL. PMID: 32446439.
      View in: PubMed   Mentions:    Fields:    
    4. Breast Cancer Screening in Women With Schizophrenia: A Systematic Review and Meta-Analysis. Psychiatr Serv. 2020 03 01; 71(3):263-268. Hwong A, Wang K, Bent S, Mangurian C. PMID: 31722645.
      View in: PubMed   Mentions: 2     Fields:    
    5. Population health interventions to improve colorectal cancer screening by fecal immunochemical tests: A systematic review. Prev Med. 2019 01; 118:113-121. Issaka RB, Avila P, Whitaker E, Bent S, Somsouk M. PMID: 30367972.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    6. Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Mol Autism. 2018; 9:35. Bent S, Lawton B, Warren T, Widjaja F, Dang K, Fahey JW, Cornblatt B, Kinchen JM, Delucchi K, Hendren RL. PMID: 29854372.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    7. Integrating Autism Care through a School-Based Intervention Model: A Pilot Study. J Clin Med. 2017 Oct 19; 6(10). Dang K, Bent S, Lawton B, Warren T, Widjaja F, McDonald MG, Breard M, O'Keefe W, Hendren RL. PMID: 29048365.
      View in: PubMed   Mentions:
    8. Anticoagulation for the treatment of venous thromboembolism in patients with brain metastases: a meta-analysis and systematic review. J Thromb Thrombolysis. 2017 Oct; 44(3):392-398. Hunter BD, Minichiello T, Bent S. PMID: 28836150.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. Open-Label Trial of Vitamin D3 Supplementation in Children with Autism Spectrum Disorder. J Altern Complement Med. 2017 May; 23(5):394-395. Bent S, Ailarov A, Dang KT, Widjaja F, Lawton BL, Hendren RL. PMID: 28437142.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    10. Examining Clinics for Children with Autism: The Autism Translating To Treatment Study. J Altern Complement Med. 2017 May; 23(5):340-347. Bent S, Dang K, Widjaja F, Lawton B, Nazneen N, Hendren RL. PMID: 28084799.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism. J Child Adolesc Psychopharmacol. 2016 11; 26(9):774-783. Hendren RL, James SJ, Widjaja F, Lawton B, Rosenblatt A, Bent S. PMID: 26889605.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    12. The Impact of Clinical Decision Rules on Computed Tomography Use and Yield for Pulmonary Embolism: A Systematic Review and Meta-analysis. Ann Emerg Med. 2016 06; 67(6):693-701.e3. Wang RC, Bent S, Weber E, Neilson J, Smith-Bindman R, Fahimi J. PMID: 26747217.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    13. Complementary and alternative treatments for autism part 1: evidence-supported treatments. AMA J Ethics. 2015 Apr 01; 17(4):369-74. Bent S, Hendren RL. PMID: 25901707.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    14. Internet-based, randomized, controlled trial of omega-3 fatty acids for hyperactivity in autism. J Am Acad Child Adolesc Psychiatry. 2014 Jun; 53(6):658-66. Bent S, Hendren RL, Zandi T, Law K, Choi JE, Widjaja F, Kalb L, Nestle J, Law P. PMID: 24839884.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    15. Brief report: Hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorder: a clinical trial. J Autism Dev Disord. 2012 Jun; 42(6):1127-32. Bent S, Bertoglio K, Ashwood P, Nemeth E, Hendren RL. PMID: 21818676.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    16. Procalcitonin-guided antibiotic therapy for chronic obstructive pulmonary disease exacerbations. Expert Rev Anti Infect Ther. 2011 Jun; 9(6):727-35. Tokman S, Schuetz P, Bent S. PMID: 21692680.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder. J Autism Dev Disord. 2011 May; 41(5):545-54. Bent S, Bertoglio K, Ashwood P, Bostrom A, Hendren RL. PMID: 20683766.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    18. Improving the prediction of response to therapy in autism. Neurotherapeutics. 2010 Jul; 7(3):232-40. Bent S, Hendren RL. PMID: 20643375.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    19. The impact of a "low-intensity" versus "high-intensity" medical intensive care unit on patient outcomes in critically ill veterans. J Intensive Care Med. 2010 Jul; 25(4):233-9. Singer JP, Kohlwes J, Bent S, Zimmerman L, Eisner MD. PMID: 20444736.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Why change is needed in research examining dietary supplements. Clin Pharmacol Ther. 2010 Feb; 87(2):147-9. Tsourounis C, Bent S. PMID: 20107446.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    21. The prognosis and treatment of acquired hemophilia: a systematic review and meta-analysis. Blood Coagul Fibrinolysis. 2009 Oct; 20(7):517-23. Bitting RL, Bent S, Li Y, Kohlwes J. PMID: 19644360.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    22. Gender as a risk factor for advanced neoplasia and colorectal cancer: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2009 Jun; 7(6):676-81.e1-3. Nguyen SP, Bent S, Chen YH, Terdiman JP. PMID: 19514116.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    23. Antibiotic and anti-inflammatory use and the risk of prostate cancer. BMC Res Notes. 2009 Apr 17; 2:57. Daniels NA, Chen YH, Bent S. PMID: 19374749.
      View in: PubMed   Mentions: 5     Fields:    
    24. Omega-3 fatty acids for autistic spectrum disorder: a systematic review. J Autism Dev Disord. 2009 Aug; 39(8):1145-54. Bent S, Bertoglio K, Hendren RL. PMID: 19333748.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    25. The relation of alpha-linolenic acid to the risk of prostate cancer: a systematic review and meta-analysis. Am J Clin Nutr. 2009 May; 89(5):1558S-1564S. Simon JA, Chen YH, Bent S. PMID: 19321563.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    26. Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin. J Gen Intern Med. 2009 May; 24(5):656-64. Kangelaris KN, Bent S, Nussbaum RL, Garcia DA, Tice JA. PMID: 19306050.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    27. Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center. J Gen Intern Med. 2008 Jun; 23(6):854-9. Bent S. PMID: 18415652.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    28. Initial experience with a group presentation of study results to research participants. Trials. 2008 Mar 21; 9:16. Avins AL, Bent S, Padula A, Staccone S, Badua E, Goldberg H. PMID: 18355417.
      View in: PubMed   Mentions: 3     Fields:    
    29. A detailed safety assessment of a saw palmetto extract. Complement Ther Med. 2008 Jun; 16(3):147-54. Avins AL, Bent S, Staccone S, Badua E, Padula A, Goldberg H, Neuhaus J, Hudes E, Shinohara K, Kane C. PMID: 18534327.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    30. Efficacy of short-course antibiotic regimens for community-acquired pneumonia: a meta-analysis. Am J Med. 2007 Sep; 120(9):783-90. Li JZ, Winston LG, Moore DH, Bent S. PMID: 17765048.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    31. Does this adult patient have septic arthritis? JAMA. 2007 Apr 04; 297(13):1478-88. Margaretten ME, Kohlwes J, Moore D, Bent S. PMID: 17405973.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    32. Valerian for sleep: a systematic review and meta-analysis. Am J Med. 2006 Dec; 119(12):1005-12. Bent S, Padula A, Moore D, Patterson M, Mehling W. PMID: 17145239.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    33. Saw palmetto and lower urinary tract symptoms: what is the latest evidence? Curr Urol Rep. 2006 Jul; 7(4):260-5. Avins AL, Bent S. PMID: 16930496.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    34. The PRIME curriculum. Clinical research training during residency. J Gen Intern Med. 2006 May; 21(5):506-9. Kohlwes RJ, Shunk RL, Avins A, Garber J, Bent S, Shlipak MG. PMID: 16704399.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    35. Brief communication: Better ways to question patients about adverse medical events: a randomized, controlled trial. Ann Intern Med. 2006 Feb 21; 144(4):257-61. Bent S, Padula A, Avins AL. PMID: 16490911.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    36. Saw palmetto for benign prostatic hyperplasia. N Engl J Med. 2006 Feb 09; 354(6):557-66. Bent S, Kane C, Shinohara K, Neuhaus J, Hudes ES, Goldberg H, Avins AL. PMID: 16467543.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCTClinical Trials
    37. Spontaneous bleeding associated with ginkgo biloba: a case report and systematic review of the literature: a case report and systematic review of the literature. J Gen Intern Med. 2005 Jul; 20(7):657-61. Bent S, Goldberg H, Padula A, Avins AL. PMID: 16050865.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    38. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. Medicine (Baltimore). 2005 Jul; 84(4):197-207. Jacobs BP, Bent S, Tice JA, Blackwell T, Cummings SR. PMID: 16010204.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCTClinical Trials
    39. Use of an embedded N-of-1 trial to improve adherence and increase information from a clinical study. Contemp Clin Trials. 2005 Jun; 26(3):397-401. Avins AL, Bent S, Neuhaus JM. PMID: 15911473.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCTClinical Trials
    40. N-acetylcysteine for the prevention of contrast-induced nephropathy. A systematic review and meta-analysis. J Gen Intern Med. 2005 Feb; 20(2):193-200. Liu R, Nair D, Ix J, Moore DH, Bent S. PMID: 15836554.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    41. Safety and efficacy of citrus aurantium for weight loss. Am J Cardiol. 2004 Nov 15; 94(10):1359-61. Bent S, Padula A, Neuhaus J. PMID: 15541270.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    42. Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents. Ann Intern Med. 2004 Oct 05; 141(7):537-46. Terasawa T, Blackmore CC, Bent S, Kohlwes RJ. PMID: 15466771.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    43. The use of systematic reviews and meta-analyses in infection control and hospital epidemiology. Am J Infect Control. 2004 Jun; 32(4):246-54. Bent S, Shojania KG, Saint S. PMID: 15175624.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    44. Commonly used herbal medicines in the United States: a review. Am J Med. 2004 Apr 01; 116(7):478-85. Bent S, Ko R. PMID: 15047038.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansPHPublic Health
    45. A randomized controlled trial of a Chinese herbal remedy to increase energy, memory, sexual function, and quality of life in elderly adults in Beijing, China. Am J Med. 2003 Oct 15; 115(6):441-7. Bent S, Xu L, Lui LY, Nevitt M, Schneider E, Tian G, Guo S, Cummings S. PMID: 14563500.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    46. Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C. A systematic review and critical analysis. Ann Intern Med. 2003 Jul 01; 139(1):46-50. Gupta S, Bent S, Kohlwes J. PMID: 12834318.
      View in: PubMed   Mentions: 96     Fields:    Translation:Humans
    47. The relative safety of ephedra compared with other herbal products. Ann Intern Med. 2003 Mar 18; 138(6):468-71. Bent S, Tiedt TN, Odden MC, Shlipak MG. PMID: 12639079.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    48. The optimal use of diagnostic testing in women with acute uncomplicated cystitis. Am J Med. 2002 Jul 08; 113 Suppl 1A:20S-28S. Bent S, Saint S. PMID: 12113868.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    49. Does this woman have an acute uncomplicated urinary tract infection? JAMA. 2002 May 22-29; 287(20):2701-10. Bent S, Nallamothu BK, Simel DL, Fihn SD, Saint S. PMID: 12020306.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    50. An evidence-based review of the 10 most commonly used herbs. West J Med. 1999 Sep; 171(3):168-71. Mar C, Bent S. PMID: 10560291.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    51. Antibiotics in acute bronchitis: a meta-analysis. Am J Med. 1999 Jul; 107(1):62-7. Bent S, Saint S, Vittinghoff E, Grady D. PMID: 10403354.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    52. Commentary: Adulterants in herbal products: dangerous and deceitful. West J Med. 1999 May; 170(5):259-60. Bent S. PMID: 18751139.
      View in: PubMed   Mentions:    Fields:    
    53. Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis. JAMA. 1995 Mar 22-29; 273(12):957-60. Saint S, Bent S, Vittinghoff E, Grady D. PMID: 7884956.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
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