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Stephen Bent, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-750-2093
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    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine - Internal Medicine

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    Dr. Bent's main research interest is the evaluation of the safety and efficacy of herbal remedies and dietary supplements. He served as the project director for one of the first large randomized controlled trials of saw palmetto for enlarged prostate, which gained international recognition for demonstrating that this commonly used herb was no more effective than placebo. Dr. Bent has also served as the principal investigator or co-investigator of several other large randomized controlled trials, including a study of a Chinese herbal remedy used to treat fatigue in the elderly and an internet-based study examining the efficacy of the herbs valerian (for sleep) and kava (for anxiety). Recently, Dr. Bent has conducted clinical trials of complementary and alternative therapies in children with autism, including studies of omega-3 fatty acids, methyl B12, sulforaphane, and vitamin D. Dr. Bent was also the Principal Investigator of the first-ever fully internet-based randomized controlled trial of a pharmaceutical drug and the first internet-based trial of a treatment (omega-3 fatty acids) conducted in children with autism. He plans to further develop internet-based technology to speed the testing of promising new therapies. Dr. Bent is an expert in evidence-based medicine and ambulatory care, and has coauthored textbooks in both areas.

    Collapse Research 
    Collapse Research Activities and Funding
    Early Identification of Adverse Reactions to Herbs
    NIH/NCCIH K08AT001338Dec 16, 2002 - Nov 30, 2008
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bent S, Lawton B, Warren T, Widjaja F, Dang K, Fahey JW, Cornblatt B, Kinchen JM, Delucchi K, Hendren RL. Identification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli. Mol Autism. 2018; 9:35. PMID: 29854372.
      View in: PubMed
    2. Dang K, Bent S, Lawton B, Warren T, Widjaja F, McDonald MG, Breard M, O'Keefe W, Hendren RL. Integrating Autism Care through a School-Based Intervention Model: A Pilot Study. J Clin Med. 2017 Oct 19; 6(10). PMID: 29048365.
      View in: PubMed
    3. Hunter BD, Minichiello T, Bent S. Anticoagulation for the treatment of venous thromboembolism in patients with brain metastases: a meta-analysis and systematic review. J Thromb Thrombolysis. 2017 Oct; 44(3):392-398. PMID: 28836150.
      View in: PubMed
    4. Bent S, Ailarov A, Dang KT, Widjaja F, Lawton BL, Hendren RL. Open-Label Trial of Vitamin D3 Supplementation in Children with Autism Spectrum Disorder. J Altern Complement Med. 2017 May; 23(5):394-395. PMID: 28437142.
      View in: PubMed
    5. Bent S, Dang K, Widjaja F, Lawton B, Nazneen N, Hendren RL. Examining Clinics for Children with Autism: The Autism Translating To Treatment Study. J Altern Complement Med. 2017 May; 23(5):340-347. PMID: 28084799.
      View in: PubMed
    6. Hendren RL, James SJ, Widjaja F, Lawton B, Rosenblatt A, Bent S. Randomized, Placebo-Controlled Trial of Methyl B12 for Children with Autism. J Child Adolesc Psychopharmacol. 2016 11; 26(9):774-783. PMID: 26889605.
      View in: PubMed
    7. Wang RC, Bent S, Weber E, Neilson J, Smith-Bindman R, Fahimi J. The Impact of Clinical Decision Rules on Computed Tomography Use and Yield for Pulmonary Embolism: A Systematic Review and Meta-analysis. Ann Emerg Med. 2016 06; 67(6):693-701.e3. PMID: 26747217.
      View in: PubMed
    8. Bent S, Hendren RL. Complementary and alternative treatments for autism part 1: evidence-supported treatments. AMA J Ethics. 2015 Apr 01; 17(4):369-74. PMID: 25901707.
      View in: PubMed
    9. Bent S, Hendren RL, Zandi T, Law K, Choi JE, Widjaja F, Kalb L, Nestle J, Law P. Internet-based, randomized, controlled trial of omega-3 fatty acids for hyperactivity in autism. J Am Acad Child Adolesc Psychiatry. 2014 Jun; 53(6):658-66. PMID: 24839884; PMCID: PMC4076340.
      View in: PubMed, PubMed Central
    10. Bent S, Bertoglio K, Ashwood P, Nemeth E, Hendren RL. Brief report: Hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorder: a clinical trial. J Autism Dev Disord. 2012 Jun; 42(6):1127-32. PMID: 21818676.
      View in: PubMed
    11. Tokman S, Schuetz P, Bent S. Procalcitonin-guided antibiotic therapy for chronic obstructive pulmonary disease exacerbations. Expert Rev Anti Infect Ther. 2011 Jun; 9(6):727-35. PMID: 21692680.
      View in: PubMed
    12. Bent S, Bertoglio K, Ashwood P, Bostrom A, Hendren RL. A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder. J Autism Dev Disord. 2011 May; 41(5):545-54. PMID: 20683766.
      View in: PubMed
    13. Bent S, Hendren RL. Improving the prediction of response to therapy in autism. Neurotherapeutics. 2010 Jul; 7(3):232-40. PMID: 20643375.
      View in: PubMed
    14. Singer JP, Kohlwes J, Bent S, Zimmerman L, Eisner MD. The impact of a "low-intensity" versus "high-intensity" medical intensive care unit on patient outcomes in critically ill veterans. J Intensive Care Med. 2010 Jul; 25(4):233-9. PMID: 20444736; PMCID: PMC3577353.
      View in: PubMed, PubMed Central
    15. Tsourounis C, Bent S. Why change is needed in research examining dietary supplements. Clin Pharmacol Ther. 2010 Feb; 87(2):147-9. PMID: 20107446.
      View in: PubMed
    16. Bitting RL, Bent S, Li Y, Kohlwes J. The prognosis and treatment of acquired hemophilia: a systematic review and meta-analysis. Blood Coagul Fibrinolysis. 2009 Oct; 20(7):517-23. PMID: 19644360.
      View in: PubMed
    17. Nguyen SP, Bent S, Chen YH, Terdiman JP. Gender as a risk factor for advanced neoplasia and colorectal cancer: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2009 Jun; 7(6):676-81.e1-3. PMID: 19514116.
      View in: PubMed
    18. Daniels NA, Chen YH, Bent S. Antibiotic and anti-inflammatory use and the risk of prostate cancer. BMC Res Notes. 2009 Apr 17; 2:57. PMID: 19374749; PMCID: PMC2672937.
      View in: PubMed, PubMed Central
    19. Bent S, Bertoglio K, Hendren RL. Omega-3 fatty acids for autistic spectrum disorder: a systematic review. J Autism Dev Disord. 2009 Aug; 39(8):1145-54. PMID: 19333748.
      View in: PubMed
    20. Simon JA, Chen YH, Bent S. The relation of alpha-linolenic acid to the risk of prostate cancer: a systematic review and meta-analysis. Am J Clin Nutr. 2009 May; 89(5):1558S-1564S. PMID: 19321563.
      View in: PubMed
    21. Kangelaris KN, Bent S, Nussbaum RL, Garcia DA, Tice JA. Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin. J Gen Intern Med. 2009 May; 24(5):656-64. PMID: 19306050; PMCID: PMC2669873.
      View in: PubMed, PubMed Central
    22. Bent S. Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center. J Gen Intern Med. 2008 Jun; 23(6):854-9. PMID: 18415652; PMCID: PMC2517879.
      View in: PubMed, PubMed Central
    23. Avins AL, Bent S, Padula A, Staccone S, Badua E, Goldberg H. Initial experience with a group presentation of study results to research participants. Trials. 2008 Mar 21; 9:16. PMID: 18355417; PMCID: PMC2322950.
      View in: PubMed, PubMed Central
    24. Avins AL, Bent S, Staccone S, Badua E, Padula A, Goldberg H, Neuhaus J, Hudes E, Shinohara K, Kane C. A detailed safety assessment of a saw palmetto extract. Complement Ther Med. 2008 Jun; 16(3):147-54. PMID: 18534327.
      View in: PubMed
    25. Li JZ, Winston LG, Moore DH, Bent S. Efficacy of short-course antibiotic regimens for community-acquired pneumonia: a meta-analysis. Am J Med. 2007 Sep; 120(9):783-90. PMID: 17765048.
      View in: PubMed
    26. Margaretten ME, Kohlwes J, Moore D, Bent S. Does this adult patient have septic arthritis? JAMA. 2007 Apr 04; 297(13):1478-88. PMID: 17405973.
      View in: PubMed
    27. Bent S, Padula A, Moore D, Patterson M, Mehling W. Valerian for sleep: a systematic review and meta-analysis. Am J Med. 2006 Dec; 119(12):1005-12. PMID: 17145239; PMCID: PMC4394901.
      View in: PubMed, PubMed Central
    28. Avins AL, Bent S. Saw palmetto and lower urinary tract symptoms: what is the latest evidence? Curr Urol Rep. 2006 Jul; 7(4):260-5. PMID: 16930496.
      View in: PubMed
    29. Kohlwes RJ, Shunk RL, Avins A, Garber J, Bent S, Shlipak MG. The PRIME curriculum. Clinical research training during residency. J Gen Intern Med. 2006 May; 21(5):506-9. PMID: 16704399; PMCID: PMC1484802.
      View in: PubMed, PubMed Central
    30. Bent S, Padula A, Avins AL. Brief communication: Better ways to question patients about adverse medical events: a randomized, controlled trial. Ann Intern Med. 2006 Feb 21; 144(4):257-61. PMID: 16490911.
      View in: PubMed
    31. Bent S, Kane C, Shinohara K, Neuhaus J, Hudes ES, Goldberg H, Avins AL. Saw palmetto for benign prostatic hyperplasia. N Engl J Med. 2006 Feb 09; 354(6):557-66. PMID: 16467543.
      View in: PubMed
    32. Bent S, Goldberg H, Padula A, Avins AL. Spontaneous bleeding associated with ginkgo biloba: a case report and systematic review of the literature: a case report and systematic review of the literature. J Gen Intern Med. 2005 Jul; 20(7):657-61. PMID: 16050865; PMCID: PMC1490168.
      View in: PubMed, PubMed Central
    33. Jacobs BP, Bent S, Tice JA, Blackwell T, Cummings SR. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. Medicine (Baltimore). 2005 Jul; 84(4):197-207. PMID: 16010204.
      View in: PubMed
    34. Avins AL, Bent S, Neuhaus JM. Use of an embedded N-of-1 trial to improve adherence and increase information from a clinical study. Contemp Clin Trials. 2005 Jun; 26(3):397-401. PMID: 15911473.
      View in: PubMed
    35. Liu R, Nair D, Ix J, Moore DH, Bent S. N-acetylcysteine for the prevention of contrast-induced nephropathy. A systematic review and meta-analysis. J Gen Intern Med. 2005 Feb; 20(2):193-200. PMID: 15836554; PMCID: PMC1490056.
      View in: PubMed, PubMed Central
    36. Bent S, Padula A, Neuhaus J. Safety and efficacy of citrus aurantium for weight loss. Am J Cardiol. 2004 Nov 15; 94(10):1359-61. PMID: 15541270.
      View in: PubMed
    37. Terasawa T, Blackmore CC, Bent S, Kohlwes RJ. Systematic review: computed tomography and ultrasonography to detect acute appendicitis in adults and adolescents. Ann Intern Med. 2004 Oct 05; 141(7):537-46. PMID: 15466771.
      View in: PubMed
    38. Bent S, Shojania KG, Saint S. The use of systematic reviews and meta-analyses in infection control and hospital epidemiology. Am J Infect Control. 2004 Jun; 32(4):246-54. PMID: 15175624.
      View in: PubMed
    39. Bent S, Ko R. Commonly used herbal medicines in the United States: a review. Am J Med. 2004 Apr 01; 116(7):478-85. PMID: 15047038.
      View in: PubMed
    40. Bent S, Xu L, Lui LY, Nevitt M, Schneider E, Tian G, Guo S, Cummings S. A randomized controlled trial of a Chinese herbal remedy to increase energy, memory, sexual function, and quality of life in elderly adults in Beijing, China. Am J Med. 2003 Oct 15; 115(6):441-7. PMID: 14563500.
      View in: PubMed
    41. Gupta S, Bent S, Kohlwes J. Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C. A systematic review and critical analysis. Ann Intern Med. 2003 Jul 01; 139(1):46-50. PMID: 12834318.
      View in: PubMed
    42. Bent S, Tiedt TN, Odden MC, Shlipak MG. The relative safety of ephedra compared with other herbal products. Ann Intern Med. 2003 Mar 18; 138(6):468-71. PMID: 12639079.
      View in: PubMed
    43. Bent S, Saint S. The optimal use of diagnostic testing in women with acute uncomplicated cystitis. Am J Med. 2002 Jul 08; 113 Suppl 1A:20S-28S. PMID: 12113868.
      View in: PubMed
    44. Bent S, Nallamothu BK, Simel DL, Fihn SD, Saint S. Does this woman have an acute uncomplicated urinary tract infection? JAMA. 2002 May 22-29; 287(20):2701-10. PMID: 12020306.
      View in: PubMed
    45. Mar C, Bent S. An evidence-based review of the 10 most commonly used herbs. West J Med. 1999 Sep; 171(3):168-71. PMID: 10560291; PMCID: PMC1305802.
      View in: PubMed, PubMed Central
    46. Bent S, Saint S, Vittinghoff E, Grady D. Antibiotics in acute bronchitis: a meta-analysis. Am J Med. 1999 Jul; 107(1):62-7. PMID: 10403354.
      View in: PubMed
    47. Bent S. Commentary: Adulterants in herbal products: dangerous and deceitful. West J Med. 1999 May; 170(5):259-60. PMID: 18751139.
      View in: PubMed
    48. Saint S, Bent S, Vittinghoff E, Grady D. Antibiotics in chronic obstructive pulmonary disease exacerbations. A meta-analysis. JAMA. 1995 Mar 22-29; 273(12):957-60. PMID: 7884956.
      View in: PubMed
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