Suzanne Noble, MD, PhD

Title(s)Associate Professor, Microbiology and Immunology
SchoolSchool of Medicine
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ORCID ORCID Icon0000-0001-9855-8448 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1997 Medicine
    University of California, San Francisco Postdoctoral StudiesGraduate Division
    University of California, San FranciscoPh.D.1995 Graduate Division (Biochemistry)

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Exploring Paneth Cell Peptide YY (PYY), a unique anti-microbial peptide that maintains fungal commensalism, in the pathogenesis of ileal Crohn?s Disease
    NIH R01DK113788Apr 1, 2017 - Feb 28, 2021
    Role: Co-Principal Investigator
    Treatment and Prevention of Systemic Candidiasis
    NIH R33AI127489Dec 9, 2016 - Nov 30, 2021
    Role: Principal Investigator
    Treatment and Prevention of Systemic Candidiasis
    NIH R21AI127489Dec 9, 2016 - Nov 30, 2018
    Role: Principal Investigator
    Signals and switches for Candida albicans commensalism
    NIH R01AI108992Dec 15, 2013 - Nov 30, 2020
    Role: Principal Investigator
    The Candida albicans commensal program
    NIH R21AI099659Feb 15, 2012 - Jan 31, 2015
    Role: Principal Investigator
    A Genetic Approach to Virulence in C. albicans
    NIH K08AI062800May 15, 2005 - Apr 30, 2010
    Role: Principal Investigator
    Comprehensive Biology: Exploiting the Yeast Genome
    NIH P41RR011823Sep 30, 1996 - Jun 30, 2016
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism. Science. 2023 08 04; 381(6657):502-508. Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB. PMID: 37535745; PMCID: PMC10876062.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    2. Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence. Nat Commun. 2023 07 27; 14(1):4528. Liu Z, Basso P, Hossain S, Liston SD, Robbins N, Whitesell L, Noble SM, Cowen LE. PMID: 37500616; PMCID: PMC10374912.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans. mBio. 2023 04 25; 14(2):e0343422. Lash E, Prudent V, Stogios PJ, Savchenko A, Noble SM, Robbins N, Cowen LE. PMID: 36809010; PMCID: PMC10128014.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response. Cell Host Microbe. 2022 11 09; 30(11):1589-1601.e5. Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM. PMID: 36323314; PMCID: PMC9744107.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    5. Christine Guthrie (1945-2022). Science. 2022 09 02; 377(6610):1049. Noble S, Burgess SM, Strauss E. PMID: 36048934.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity. Cell Rep. 2022 05 17; 39(7):110837. Shao TY, Kakade P, Witchley JN, Frazer C, Murray KL, Ene IV, Haslam DB, Hagan T, Noble SM, Bennett RJ, Way SS. PMID: 35584674; PMCID: PMC9196946.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    7. Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets. Nat Commun. 2021 11 11; 12(1):6497. Fu C, Zhang X, Veri AO, Iyer KR, Lash E, Xue A, Yan H, Revie NM, Wong C, Lin ZY, Polvi EJ, Liston SD, VanderSluis B, Hou J, Yashiroda Y, Gingras AC, Boone C, O'Meara TR, O'Meara MJ, Noble S, Robbins N, Myers CL, Cowen LE. PMID: 34764269; PMCID: PMC8586148.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    8. Adaptive immunity induces mutualism between commensal eukaryotes. Nature. 2021 08; 596(7870):114-118. Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. PMID: 34262174; PMCID: PMC8904204.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimals
    9. Recording of DNA-binding events reveals the importance of a repurposed Candida albicans regulatory network for gut commensalism. Cell Host Microbe. 2021 06 09; 29(6):1002-1013.e9. Witchley JN, Basso P, Brimacombe CA, Abon NV, Noble SM. PMID: 33915113; PMCID: PMC8216204.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    10. Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization. J Vis Exp. 2019 11 05; (153). Witchley JN, Penumetcha PM, Noble SM. PMID: 31762460.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    11. A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. PLoS Biol. 2019 06; 17(6):e3000331. Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM. PMID: 31226107; PMCID: PMC6613695.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    12. Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection. Cell Host Microbe. 2019 Mar 13; 25(3):432-443.e6. Witchley JN, Penumetcha P, Abon NV, Woolford CA, Mitchell AP, Noble SM. PMID: 30870623; PMCID: PMC6581065.
      View in: PubMed   Mentions: 103     Fields:    Translation:Animals
    13. High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis. mBio. 2018 08 21; 9(4). O'Meara TR, Duah K, Guo CX, Maxson ME, Gaudet RG, Koselny K, Wellington M, Powers ME, MacAlpine J, O'Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen SD, Cowen LE. PMID: 30131363; PMCID: PMC6106084.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    14. Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections. Nat Commun. 2017 09 19; 8(1):599. Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA. PMID: 28928442; PMCID: PMC5605711.
      View in: PubMed   Mentions: 161     Fields:    Translation:Humans
    15. Candida albicans cell-type switching and functional plasticity in the mammalian host. Nat Rev Microbiol. 2017 02; 15(2):96-108. Noble SM, Gianetti BA, Witchley JN. PMID: 27867199; PMCID: PMC5957277.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansAnimalsCells
    16. Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa. J Bacteriol. 2014 May; 196(9):1683-93. Phelan VV, Moree WJ, Aguilar J, Cornett DS, Koumoutsi A, Noble SM, Pogliano K, Guerrero CA, Dorrestein PC. PMID: 24532776; PMCID: PMC3993319.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    17. Candida albicans specializations for iron homeostasis: from commensalism to virulence. Curr Opin Microbiol. 2013 Dec; 16(6):708-15. Noble SM. PMID: 24121029; PMCID: PMC3855070.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    18. Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism. Nat Genet. 2013 Sep; 45(9):1088-91. Pande K, Chen C, Noble SM. PMID: 23892606; PMCID: PMC3758371.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimals
    19. Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host. PLoS Pathog. 2012; 8(11):e1002956. Chen C, Noble SM. PMID: 23133381; PMCID: PMC3486892.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    20. An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. Cell Host Microbe. 2011 Aug 18; 10(2):118-35. Chen C, Pande K, French SD, Tuch BB, Noble SM. PMID: 21843869; PMCID: PMC3165008.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    21. Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Nat Genet. 2010 Jul; 42(7):590-8. Noble SM, French S, Kohn LA, Chen V, Johnson AD. PMID: 20543849; PMCID: PMC2893244.
      View in: PubMed   Mentions: 397     Fields:    Translation:HumansAnimalsCells
    22. Genetics and molecular biology in Candida albicans. Methods Enzymol. 2010; 470:737-58. Hernday AD, Noble SM, Mitrovich QM, Johnson AD. PMID: 20946834.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    23. A phenotypic profile of the Candida albicans regulatory network. PLoS Genet. 2009 Dec; 5(12):e1000783. Homann OR, Dea J, Noble SM, Johnson AD. PMID: 20041210; PMCID: PMC2790342.
      View in: PubMed   Mentions: 274     Fields:    Translation:AnimalsCells
    24. An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. PLoS Genet. 2009 Sep; 5(9):e1000664. Elson SL, Noble SM, Solis NV, Filler SG, Johnson AD. PMID: 19779551; PMCID: PMC2739428.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    25. Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell. 2008 Oct 03; 135(1):174-88. Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM. PMID: 18854164; PMCID: PMC2628477.
      View in: PubMed   Mentions: 246     Fields:    Translation:HumansAnimals
    26. Genetics of Candida albicans, a diploid human fungal pathogen. Annu Rev Genet. 2007; 41:193-211. Noble SM, Johnson AD. PMID: 17614788.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    27. Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence. Mol Biol Cell. 2005 Oct; 16(10):4814-26. Hromatka BS, Noble SM, Johnson AD. PMID: 16030247; PMCID: PMC1237085.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    28. Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans. Eukaryot Cell. 2005 Feb; 4(2):298-309. Noble SM, Johnson AD. PMID: 15701792; PMCID: PMC549318.
      View in: PubMed   Mentions: 338     Fields:    Translation:HumansAnimals
    29. Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF). Science. 1996 Nov 29; 274(5292):1511-4. Chanfreau G, Noble SM, Guthrie C. PMID: 8929408.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    30. Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. EMBO J. 1996 Aug 15; 15(16):4368-79. Noble SM, Guthrie C. PMID: 8861964; PMCID: PMC452161.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    31. Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics. 1996 May; 143(1):67-80. Noble SM, Guthrie C. PMID: 8722763; PMCID: PMC1207296.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
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