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Eric Chow, PhD

Title(s)Assistant Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone415-418-3658
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    Collapse Biography 
    Collapse Education and Training
    University of California San FranciscoPhD12/2012Biochemistry
    University of California BerkeleyBA05/2003Molecular Biology

    Collapse Overview 
    Collapse Overview
    Eric Chow, PhD is an assistant professor in the Department of Biochemistry and Biophysics and Director of the Center for Advanced Technology (CAT) at UCSF. The CAT evaluates and brings new technologies top campus that are available to all UCSF labs and provides guidance for projects. Over the past decade, the CAT has been a hub for Next Generation Sequencing (NGS) at UCSF and beyond, supporting the development of NGS-based non-invasive pre-natal testing and pathogen diagnostics. Dr. Chow also runs a research program to devise new applications for NGS and to develop rapid pathogen detection systems in resource poor settings. He received his BA from the University of California, Berkeley, and his PhD performing genomic research in Tuberculosis at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Illumina NovaSeq 6000 Sequencing System
    NIH S10OD028511Jun 1, 2020 - May 31, 2021
    Role: Principal Investigator
    BRASL - A rapid Barcoded RNA Annealing, Selection, and Ligation assay to detect pathogens.
    NIH/NIAID R21AI120972Dec 1, 2015 - Nov 30, 2017
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Robust Sequence Determinants of a-Synuclein Toxicity in Yeast Implicate Membrane Binding. ACS Chem Biol. 2020 Aug 21; 15(8):2137-2153. Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZC, Pittman M, Reddy NR, Schwarz DMC, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M. PMID: 32786289.
      View in: PubMed   Mentions:    Fields:    
    2. The DNA methylation landscape of advanced prostate cancer. Nat Genet. 2020 Aug; 52(8):778-789. Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY. PMID: 32661416.
      View in: PubMed   Mentions:    Fields:    
    3. ZipSeq: barcoding for real-time mapping of single cell transcriptomes. Nat Methods. 2020 Aug; 17(8):833-843. Hu KH, Eichorst JP, McGinnis CS, Patterson DM, Chow ED, Kersten K, Jameson SC, Gartner ZJ, Rao AA, Krummel MF. PMID: 32632238.
      View in: PubMed   Mentions:    Fields:    
    4. Deep mutational scanning reveals the structural basis for a-synuclein activity. Nat Chem Biol. 2020 06; 16(6):653-659. Newberry RW, Leong JT, Chow ED, Kampmann M, DeGrado WF. PMID: 32152544.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. FLASH: a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences. Nucleic Acids Res. 2019 08 22; 47(14):e83. Quan J, Langelier C, Kuchta A, Batson J, Teyssier N, Lyden A, Caldera S, McGeever A, Dimitrov B, King R, Wilheim J, Murphy M, Ares LP, Travisano KA, Sit R, Amato R, Mumbengegwi DR, Smith JL, Bennett A, Gosling R, Mourani PM, Calfee CS, Neff NF, Chow ED, Kim PS, Greenhouse B, DeRisi JL, Crawford ED. PMID: 31114866.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    6. MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. Nat Methods. 2019 07; 16(7):619-626. McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ. PMID: 31209384.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    7. Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children. Clin Infect Dis. 2019 05 17; 68(11):1847-1855. Zinter MS, Dvorak CC, Mayday MY, Iwanaga K, Ly NP, McGarry ME, Church GD, Faricy LE, Rowan CM, Hume JR, Steiner ME, Crawford ED, Langelier C, Kalantar K, Chow ED, Miller S, Shimano K, Melton A, Yanik GA, Sapru A, DeRisi JL. PMID: 30239621.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. Predicting Splicing from Primary Sequence with Deep Learning. Cell. 2019 01 24; 176(3):535-548.e24. Jaganathan K, Kyriazopoulou Panagiotopoulou S, McRae JF, Darbandi SF, Knowles D, Li YI, Kosmicki JA, Arbelaez J, Cui W, Schwartz GB, Chow ED, Kanterakis E, Gao H, Kia A, Batzoglou S, Sanders SJ, Farh KK. PMID: 30661751.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    9. Miniaturization and optimization of 384-well compatible RNA sequencing library preparation. PLoS One. 2019; 14(1):e0206194. Mayday MY, Khan LM, Chow ED, Zinter MS, DeRisi JL. PMID: 30629604.
      View in: PubMed   Mentions: 5     Fields:    
    10. Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12353-E12362. Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL. PMID: 30482864.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    11. Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. JAMA Neurol. 2018 08 01; 75(8):947-955. Wilson MR, O'Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi JL. PMID: 29710329.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    12. Mass Azithromycin Distribution and Community Microbiome: A Cluster-Randomized Trial. Open Forum Infect Dis. 2018 Aug; 5(8):ofy182. Doan T, Hinterwirth A, Arzika AM, Cotter SY, Ray KJ, O'Brien KS, Zhong L, Chow ED, Zhou Z, Cummings SL, Fry D, Oldenburg CE, Worden L, Porco TC, Keenan JD, Lietman TM. PMID: 30151409.
      View in: PubMed   Mentions:
    13. Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. Biol Open. 2018 Jul 23; 7(7). Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio CM, Dai SA, Dickinson MS, Elledge SK, Helsell CVM, Hendel NL, Kang E, Kern N, Khoroshkin MS, Kirkemo LL, Lewis GR, Lou K, Marin WM, Maxwell AM, McTigue PF, Myers-Turnbull D, Nagy TL, Natale AM, Oltion K, Pourmal S, Reder GK, Rettko NJ, Rohweder PJ, Schwarz DMC, Tan SK, Thomas PV, Tibble RW, Town JP, Tsai MK, Ugur FS, Wassarman DR, Wolff AM, Wu TS, Bogdanoff D, Li J, Thorn KS, O'Conchúir S, Swaney DL, Chow ED, Madhani HD, Redding S, Bolon DN, Kortemme T, DeRisi JL, Kampmann M, Fraser JS. PMID: 30037883.
      View in: PubMed   Mentions:
    14. Mapping the Genetic Landscape of Human Cells. Cell. 2018 08 09; 174(4):953-967.e22. Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA. PMID: 30033366.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    15. Metagenomic DNA Sequencing for the Diagnosis of Intraocular Infections. Ophthalmology. 2017 08; 124(8):1247-1248. Doan T, Acharya NR, Pinsky BA, Sahoo MK, Chow ED, Banaei N, Budvytiene I, Cevallos V, Zhong L, Zhou Z, Lietman TM, DeRisi JL. PMID: 28526549.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. Erratum to: Illuminating uveitis: metagenomic deep sequencing identifies common and rare pathogens. Genome Med. 2016 11 22; 8(1):123. Doan T, Wilson MR, Crawford ED, Chow ED, Khan LM, Knopp KA, O'Donovan BD, Xia D, Hacker JK, Stewart JM, Gonzales JA, Acharya NR, DeRisi JL. PMID: 27876088.
      View in: PubMed   Mentions:    Fields:    
    17. UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes. Nat Microbiol. 2016 Sep 19; 1:16166. Lim MY, LaMonte G, Lee MCS, Reimer C, Tan BH, Corey V, Tjahjadi BF, Chua A, Nachon M, Wintjens R, Gedeck P, Malleret B, Renia L, Bonamy GMC, Ho PC, Yeung BKS, Chow ED, Lim L, Fidock DA, Diagana TT, Winzeler EA, Bifani P. PMID: 27642791.
      View in: PubMed   Mentions: 20     Fields:    
    18. Illuminating uveitis: metagenomic deep sequencing identifies common and rare pathogens. Genome Med. 2016 08 25; 8(1):90. Doan T, Wilson MR, Crawford ED, Chow ED, Khan LM, Knopp KA, O'Donovan BD, Xia D, Hacker JK, Stewart JM, Gonzales JA, Acharya NR, DeRisi JL. PMID: 27562436.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    19. Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting. Elife. 2016 04 25; 5. Mavor D, Barlow K, Thompson S, Barad BA, Bonny AR, Cario CL, Gaskins G, Liu Z, Deming L, Axen SD, Caceres E, Chen W, Cuesta A, Gate RE, Green EM, Hulce KR, Ji W, Kenner LR, Mensa B, Morinishi LS, Moss SM, Mravic M, Muir RK, Niekamp S, Nnadi CI, Palovcak E, Poss EM, Ross TD, Salcedo EC, See SK, Subramaniam M, Wong AW, Li J, Thorn KS, Conchúir SÓ, Roscoe BP, Chow ED, DeRisi JL, Kortemme T, Bolon DN, Fraser JS. PMID: 27111525.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    20. Depletion of Abundant Sequences by Hybridization (DASH): using Cas9 to remove unwanted high-abundance species in sequencing libraries and molecular counting applications. Genome Biol. 2016 Mar 04; 17:41. Gu W, Crawford ED, O'Donovan BD, Wilson MR, Chow ED, Retallack H, DeRisi JL. PMID: 26944702.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    21. Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia. Blood. 2015 Jan 15; 125(3):516-24. Stieglitz E, Troup CB, Gelston LC, Haliburton J, Chow ED, Yu KB, Akutagawa J, Taylor-Weiner AN, Liu YL, Wang YD, Beckman K, Emanuel PD, Braun BS, Abate A, Gerbing RB, Alonzo TA, Loh ML. PMID: 25395418.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    22. A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrob Agents Chemother. 2013 Dec; 57(12):6063-73. Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey CR. PMID: 24060869.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    23. Genetic and mass spectrometric tools for elucidating the physiological function(s) of cytochrome P450 enzymes from Mycobacterium tuberculosis. Methods Mol Biol. 2013; 987:79-94. Ouellet H, Chow ED, Guan S, Cox JS, Burlingame AL, de Montellano PR. PMID: 23475669.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    24. TB lipidomics--the final frontier. Chem Biol. 2011 Dec 23; 18(12):1517-8. Chow ED, Cox JS. PMID: 22195552.
      View in: PubMed   Mentions: 2     Fields:    
    25. Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one. Mol Microbiol. 2010 Aug; 77(3):730-42. Ouellet H, Guan S, Johnston JB, Chow ED, Kells PM, Burlingame AL, Cox JS, Podust LM, de Montellano PR. PMID: 20545858.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    26. Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell. 2008 Oct 03; 135(1):174-88. Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM. PMID: 18854164.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansAnimals
    27. Exploration of whole-genome responses of the human AIDS-associated yeast pathogen Cryptococcus neoformans var grubii: nitric oxide stress and body temperature. Curr Genet. 2007 Sep; 52(3-4):137-48. Chow ED, Liu OW, O'Brien S, Madhani HD. PMID: 17661046.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    28. Parallel beta-helix proteins required for accurate capsule polysaccharide synthesis and virulence in the yeast Cryptococcus neoformans. Eukaryot Cell. 2007 Apr; 6(4):630-40. Liu OW, Kelly MJ, Chow ED, Madhani HD. PMID: 17337638.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
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