Tiffany Scharschmidt, MD

Title(s)Associate Professor, Dermatology
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Awards and Honors
    Doris Duke Charitable Foundation2017Clinical Scientist Development Award
    Burroughs Wellcome Fund2016Career Award for Medical Scientists
    American Academy of Dermatology2016Young Investigator Award
    Midwinter Conference of Immunologists 2015Ray Owen Young Investigator Award
    Dermatology Foundation2013  - 2015Physician Scientist Career Development Award
    National Institutes of Health2018Director’s New Innovator Award

    Collapse Research 
    Collapse Research Activities and Funding
    Decoding and harnessing microbial tuning of T cell responses in early life
    NIH/NIAID DP2AI144968Sep 30, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Elucidating mechanisms of tolerance to commensal skin bacteria
    NIH/NIAMS K08AR068409Aug 1, 2015 - Jul 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Scharschmidt TC. Antibiotics for Acne-A Pilot Study of Collateral Damage to the Skin Microbiome. JAMA Dermatol. 2019 Feb 13. PMID: 30758480.
      View in: PubMed
    2. Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD. The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells. Sci Immunol. 2018 Dec 21; 3(30). PMID: 30578350.
      View in: PubMed
    3. Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD. The microbiome in patients with atopic dermatitis. J Allergy Clin Immunol. 2019 Jan; 143(1):26-35. PMID: 30476499.
      View in: PubMed
    4. Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W. Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization. Microbiome. 2018 09 05; 6(1):154. PMID: 30185226.
      View in: PubMed
    5. Dhariwala MO, Scharschmidt TC. Skin Commensal Antigens: Taking the Road Less Traveled. Trends Immunol. 2018 04; 39(4):259-261. PMID: 29478772.
      View in: PubMed
    6. Saeed L, Schmidt TH, Gensler LS, Gross AJ, Fox LP, Scharschmidt TC, Gaensler K, Naik H, Rosenblum MA, Shinkai K. Successful treatment of mucous membrane pemphigoid with bortezomib. JAAD Case Rep. 2018 Jan; 4(1):81-83. PMID: 29387757.
      View in: PubMed
    7. Scharschmidt TC. Skin Dysbiosis Goes "Off-Leish". Cell Host Microbe. 2017 Jul 12; 22(1):1-3. PMID: 28704646.
      View in: PubMed
    8. Scharschmidt TC. A vitamin to D-crease sunburn. Sci Transl Med. 2017 06 14; 9(394). PMID: 28615360.
      View in: PubMed
    9. Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell. 2017 Jun 01; 169(6):1119-1129.e11. PMID: 28552347.
      View in: PubMed
    10. Scharschmidt TC. Measuring inflammation in IBD with an OSM-ostat. Sci Transl Med. 2017 05 03; 9(388). PMID: 28469037.
      View in: PubMed
    11. Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD. Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin. Cell Host Microbe. 2017 Apr 12; 21(4):467-477.e5. PMID: 28343820.
      View in: PubMed
    12. Scharschmidt TC. When TLRs fail, IgG has your back. Sci Transl Med. 2017 03 22; 9(382). PMID: 28330862.
      View in: PubMed
    13. Scharschmidt TC. Establishing Tolerance to Commensal Skin Bacteria: Timing Is Everything. Dermatol Clin. 2017 Jan; 35(1):1-9. PMID: 27890233.
      View in: PubMed
    14. Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, Ali NH, Pauli ML, Abbas AK, Rosenblum MD. Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing. J Immunol. 2016 Mar 01; 196(5):2010-4. PMID: 26826250; PMCID: PMC4761457 [Available on 03/01/17].
    15. Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD. A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity. 2015 Nov 17; 43(5):1011-21. PMID: 26588783; PMCID: PMC4654993 [Available on 11/17/16].
    16. Lin TK, Man MQ, Santiago JL, Scharschmidt TC, Hupe M, Martin-Ezquerra G, Youm JK, Zhai Y, Trullas C, Feingold KR, Elias PM. Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid mediated. J Invest Dermatol. 2014 Dec; 134(12):2890-2897. PMID: 24991965; PMCID: PMC4227540.
    17. Scharschmidt TC, Fischbach MA. What Lives On Our Skin: Ecology, Genomics and Therapeutic Opportunities Of the Skin Microbiome. Drug Discov Today Dis Mech. 2013 Dec 01; 10(3-4). PMID: 24273587.
      View in: PubMed
    18. Scharschmidt TC, Amerson EH, Rosenberg OS, Jacobs RA, McCalmont TH, Shinkai K. Immune reconstitution reactions in human immunodeficiency virus-negative patients: report of a case and review of the literature. JAMA Dermatol. 2013 Jan; 149(1):74-8. PMID: 23324760; PMCID: PMC3773570.
    19. Scharschmidt TC, Yost JM, Truong SV, Steinhoff M, Wang KC, Berger TG. Neurogenic rosacea: a distinct clinical subtype requiring a modified approach to treatment. Arch Dermatol. 2011 Jan; 147(1):123-6. PMID: 21242409; PMCID: PMC3692271.
    20. Gunathilake R, Schmuth M, Scharschmidt TC, Gruber R, Grabher D, Leslie KS, Maurer TA, Mauro TM, Elias PM. Epidermal barrier dysfunction in non-atopic HIV: evidence for an "inside-to-outside" pathogenesis. J Invest Dermatol. 2010 Apr; 130(4):1185-8. PMID: 19924137; PMCID: PMC4548930.
    21. Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol. 2009 Sep; 124(3):496-506, 506.e1-6. PMID: 19733297; PMCID: PMC2881668.
    22. Scharschmidt TC, List K, Grice EA, Szabo R, Renaud G, Lee CC, Wolfsberg TG, Bugge TH, Segre JA. Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota. J Invest Dermatol. 2009 Oct; 129(10):2435-42. PMID: 19387477.
      View in: PubMed
    23. Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM. Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis. J Invest Dermatol. 2009 Jul; 129(7):1824-35. PMID: 19177139; PMCID: PMC2695850.
    24. Scharschmidt TC, Segre JA. Modeling atopic dermatitis with increasingly complex mouse models. J Invest Dermatol. 2008 May; 128(5):1061-4. PMID: 18408744.
      View in: PubMed
    25. List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, Bugge TH. Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem. 2007 Dec 14; 282(50):36714-23. PMID: 17940283.
      View in: PubMed
    26. Scharschmidt T, Lo B. Clinical trial design issues raised during recombinant DNA advisory committee review of gene transfer protocols. Hum Gene Ther. 2006 Apr; 17(4):448-54. PMID: 16610932.
      View in: PubMed
    27. An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC. Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens. J Biol Chem. 2001 May 25; 276(21):17808-14. PMID: 11279159.
      View in: PubMed