Tiffany Scharschmidt, MD

Title(s)Associate Professor, Dermatology
SchoolSchool of Medicine
ORCID ORCID Icon0000-0001-5517-089X Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    Doris Duke Charitable Foundation2017Clinical Scientist Development Award
    Burroughs Wellcome Fund2016Career Award for Medical Scientists
    American Academy of Dermatology2016Young Investigator Award
    Midwinter Conference of Immunologists 2015Ray Owen Young Investigator Award
    Dermatology Foundation2013  - 2015Physician Scientist Career Development Award
    National Institutes of Health2018Director’s New Innovator Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Decoding and harnessing microbial tuning of T cell responses in early life
    NIH DP2AI144968Sep 30, 2018 - Jun 30, 2023
    Role: Principal Investigator
    Elucidating mechanisms of tolerance to commensal skin bacteria
    NIH K08AR068409Aug 1, 2015 - Jul 31, 2020
    Role: Principal Investigator

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hair of the mouse: A skin bacteria "cocktail" gets follicles back on their feet. Cell Host Microbe. 2021 05 12; 29(5):742-744. Gonzalez JR, Merana GR, Scharschmidt TC. PMID: 33984276.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020 Nov 17; 1(8):100132. Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC. PMID: 33294857.
      View in: PubMed   Mentions:
    3. Atlas of atopic dermatitis. J Allergy Clin Immunol. 2020 06; 145(6):1558-1559. Boothby IC, Gonzalez JR, Scharschmidt TC. PMID: 32344054.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Elucidating the Role of the Skin Barrier Protein Filaggrin in the Adaptive Immune Response to Commensals. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Jeanmarie R. Gonzalez, Tiffany C. Scharschmidt. .
      View in: Publisher Site   Mentions:
    5. Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. JCI Insight. 2019 12 19; 4(24). Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD. PMID: 31852848.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    6. Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria. Cell Host Microbe. 2019 12 11; 26(6):795-809.e5. Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC. PMID: 31784259.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    7. MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Science. 2019 10 25; 366(6464). Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y. PMID: 31649166.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    8. Antibiotics for Acne-A Pilot Study of Collateral Damage to the Skin Microbiome. JAMA Dermatol. 2019 04 01; 155(4):419-421. Scharschmidt TC. PMID: 30758480.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells. Sci Immunol. 2018 12 21; 3(30). Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD. PMID: 30578350.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    10. The microbiome in patients with atopic dermatitis. J Allergy Clin Immunol. 2019 01; 143(1):26-35. Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD. PMID: 30476499.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    11. Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization. Microbiome. 2018 09 05; 6(1):154. Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W. PMID: 30185226.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    12. Skin Commensal Antigens: Taking the Road Less Traveled. Trends Immunol. 2018 04; 39(4):259-261. Dhariwala MO, Scharschmidt TC. PMID: 29478772.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    13. Fighting staph: Not child’s play. Science Translational Medicine. 2018 Jan 17; 10(424):eaar7518. Tiffany C. Scharschmidt. .
      View in: Publisher Site   Mentions:
    14. Successful treatment of mucous membrane pemphigoid with bortezomib. JAAD Case Rep. 2018 Jan; 4(1):81-83. Saeed L, Schmidt TH, Gensler LS, Gross AJ, Fox LP, Scharschmidt TC, Gaensler K, Naik H, Rosenblum MA, Shinkai K. PMID: 29387757.
      View in: PubMed   Mentions:
    15. S. aureus induces IL-36 to start the itch. Science Translational Medicine. 2017 Nov 29; 9(418):eaar2445. Tiffany C. Scharschmidt. .
      View in: Publisher Site   Mentions:
    16. Growing good bugs with mom’s milk. Science Translational Medicine. 2017 Oct 18; 9(412):eaap8172. Tiffany C. Scharschmidt. .
      View in: Publisher Site   Mentions:
    17. ILC regs : The new kid in class. Science Translational Medicine. 2017 Sep 6; 9(406):eaao6121. Tiffany C. Scharschmidt. .
      View in: Publisher Site   Mentions:
    18. Interferon with antitumor immunity. Science Translational Medicine. 2017 Jul 26; 9(400):eaao0976. Tiffany C. Scharschmidt. .
      View in: Publisher Site   Mentions:
    19. Skin Dysbiosis Goes "Off-Leish". . 2017 Jul 12; 22(1):1-3. Scharschmidt TC. PMID: 28704646.
      View in: PubMed   Mentions:
    20. A vitamin to D-crease sunburn. Sci Transl Med. 2017 06 14; 9(394). Scharschmidt TC. PMID: 28615360.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    21. Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell. 2017 Jun 01; 169(6):1119-1129.e11. Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. PMID: 28552347.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    22. Measuring inflammation in IBD with an OSM-ostat. Sci Transl Med. 2017 05 03; 9(388). Scharschmidt TC. PMID: 28469037.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin. . 2017 Apr 12; 21(4):467-477.e5. Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD. PMID: 28343820.
      View in: PubMed   Mentions:
    24. When TLRs fail, IgG has your back. Sci Transl Med. 2017 03 22; 9(382). Scharschmidt TC. PMID: 28330862.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Establishing Tolerance to Commensal Skin Bacteria: Timing Is Everything. Dermatol Clin. 2017 Jan; 35(1):1-9. Scharschmidt TC. PMID: 27890233.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    26. 014 Commensal microbes augment expression of the hair follicle chemokine Ccl20 to facilitate accumulation of Tregs in neonatal skin. Journal of Investigative Dermatology. 2016 May 1; 136(5):s3. T.C. Scharschmidt, K.S. Vasquez, M.L. Pauli, H. Truong, J.L. Sonnenburg, S.E. Millar, M.D. Rosenblum. .
      View in: Publisher Site   Mentions:
    27. Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing. J Immunol. 2016 Mar 01; 196(5):2010-4. Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, Ali NH, Pauli ML, Abbas AK, Rosenblum MD. PMID: 26826250.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    28. A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity. 2015 Nov 17; 43(5):1011-21. Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD. PMID: 26588783.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    29. Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid mediated. J Invest Dermatol. 2014 Dec; 134(12):2890-2897. Lin TK, Man MQ, Santiago JL, Scharschmidt TC, Hupe M, Martin-Ezquerra G, Youm JK, Zhai Y, Trullas C, Feingold KR, Elias PM. PMID: 24991965.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    30. What Lives On Our Skin: Ecology, Genomics and Therapeutic Opportunities Of the Skin Microbiome. Drug Discov Today Dis Mech. 2013 Dec 01; 10(3-4). Scharschmidt TC, Fischbach MA. PMID: 24273587.
      View in: PubMed   Mentions:
    31. Immune reconstitution reactions in human immunodeficiency virus-negative patients: report of a case and review of the literature. JAMA Dermatol. 2013 Jan; 149(1):74-8. Scharschmidt TC, Amerson EH, Rosenberg OS, Jacobs RA, McCalmont TH, Shinkai K. PMID: 23324760.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    32. Neurogenic rosacea: a distinct clinical subtype requiring a modified approach to treatment. Arch Dermatol. 2011 Jan; 147(1):123-6. Scharschmidt TC, Yost JM, Truong SV, Steinhoff M, Wang KC, Berger TG. PMID: 21242409.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    33. Epidermal barrier dysfunction in non-atopic HIV: evidence for an "inside-to-outside" pathogenesis. J Invest Dermatol. 2010 Apr; 130(4):1185-8. Gunathilake R, Schmuth M, Scharschmidt TC, Gruber R, Grabher D, Leslie KS, Maurer TA, Mauro TM, Elias PM. PMID: 19924137.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol. 2009 Sep; 124(3):496-506, 506.e1-6. Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM. PMID: 19733297.
      View in: PubMed   Mentions: 68     Fields:    Translation:Animals
    35. Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota. J Invest Dermatol. 2009 Oct; 129(10):2435-42. Scharschmidt TC, List K, Grice EA, Szabo R, NISC Comparative Sequencing Program , Renaud G, Lee CC, Wolfsberg TG, Bugge TH, Segre JA. PMID: 19387477.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    36. Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis. J Invest Dermatol. 2009 Jul; 129(7):1824-35. Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM. PMID: 19177139.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    37. Modeling atopic dermatitis with increasingly complex mouse models. J Invest Dermatol. 2008 May; 128(5):1061-4. Scharschmidt TC, Segre JA. PMID: 18408744.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    38. Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem. 2007 Dec 14; 282(50):36714-23. List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, Bugge TH. PMID: 17940283.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    39. Clinical trial design issues raised during recombinant DNA advisory committee review of gene transfer protocols. Hum Gene Ther. 2006 Apr; 17(4):448-54. Scharschmidt T, Lo B. PMID: 16610932.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Clinical Trial Design Issues Raised During Recombinant DNA Advisory Committee Review of Gene Transfer Protocols. Human Gene Therapy. 2006 Mar 1; 0(0):060301061832002. Tiffany Scharschmidt, Bernard Lo. .
      View in: Publisher Site   Mentions:
    41. Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens. J Biol Chem. 2001 May 25; 276(21):17808-14. An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC. PMID: 11279159.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
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