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Staphylococcus aureus-specific skin resident memory T cells protect against bacteria colonization but exacerbate atopic dermatitis-like flares in mice. J Allergy Clin Immunol. 2024 Aug; 154(2):355-374.
Braun C, Badiou C, Guironnet-Paquet A, Iwata M, Lenief V, Mosnier A, Beauclair C, Renucci E, Bouschon P, Cuzin R, Briend Y, Patra V, Patot S, Scharschmidt TC, van Wamel W, Lemmens N, Nakajima S, Vandenesh F, Nicolas JF, Lina G, Nosbaum A, Vocanson M. PMID: 38734386.
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AnimalsCells
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Preclinical Atopic Dermatitis Skin in Infants: An Emerging Research Area. J Invest Dermatol. 2024 May; 144(5):1001-1009.
Paller AS, Scharschmidt TC, Kezic S, Irvine AD. PMID: 38573278.
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Humans
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218 Staphylococcus aureus-specific skin resident memory T cells protect against bacteria colonization but exacerbate atopic dermatitis-like flares in mice. Journal of Investigative Dermatology. 2023 Nov 1; 143(11):s369.
Braun BC, Badiou BC, Guironnet-Paquet GA, Iwata IM, Lenief LV, Mosnier MA, Beauclair BC, Renucci RE, Bouchon BP, Cuzin CR, Briend BY, Patra PV, Patot PS, Scharschmidt ST, van Wamel vW, Lemmens LN, Nakajima NS, Vandenesh VF, Nicolas NJ, Lina LG, Nosbaum NA, Vocanson VM. .
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Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation. bioRxiv. 2023 Oct 02.
Dhariwala MO, DeRogatis AM, Okoro JN, Weckel A, Tran VM, Habrylo I, Ojewumi OT, Tammen AE, Leech JM, Merana GR, Carale RO, Barrere-Cain R, Hiam-Galvez KJ, Spitzer MH, Scharschmidt TC. PMID: 37873143; PMCID: PMC10592812.
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LB1714 Increased epidermal penetration in aged skin modulates systemic inflammation. Journal of Investigative Dermatology. 2023 Sep 1; 143(9):b18.
Celli CA, Man MM, Gonzalez GJ, Parenteau PT, Meyer MJ, Elias EP, Abuabara AK, Grunfeld GC, Scharschmidt ST, Mauro MT. .
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Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup. Immunity. 2023 06 13; 56(6):1239-1254.e7.
Weckel A, Dhariwala MO, Ly K, Tran VM, Ojewumi OT, Riggs JB, Gonzalez JR, Dwyer LR, Okoro JN, Leech JM, Bacino MS, Cho GD, Merana G, Anandasabapathy N, Kumamoto Y, Scharschmidt TC. PMID: 37028427; PMCID: PMC10330031.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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FLG Deficiency in Mice Alters the Early-Life CD4+ T-Cell Response to Skin Commensal Bacteria. J Invest Dermatol. 2023 05; 143(5):790-800.e12.
Gonzalez JR, Celli A, Weckel A, Dhariwala MO, Merana GR, Ojewumi OT, Okoro J, Dwyer LR, Tran VM, Meyer JM, Mauro TM, Scharschmidt TC. PMID: 36496196.
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3 Fields:
Translation:
AnimalsCells
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The best offense is a good beta-defensin. Immunity. 2022 09 13; 55(9):1586-1588.
Dhariwala MO, Scharschmidt TC. PMID: 36103856.
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Cells
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544 Commensal induced accumulation of monocyte-derived cells in neonatal skin regulates long-term cutaneous type 17 inflammation. Journal of Investigative Dermatology. 2022 Aug 1; 142(8):s92.
Dhariwala DM, Okoro OJ, Scharschmidt ST. .
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561 Filaggrin deficiency confers an altered early life T cell response to commensal skin bacteria. Journal of Investigative Dermatology. 2022 Aug 1; 142(8):s95.
Gonzalez GJ, Scharschmidt ST. .
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Early life tolerance depends on a subset of specialized dendritic cells and is reinforced by the skin microbiota. BioRxiv. 2022.
View Publication.
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Intestinal inflammation alters the antigen-specific immune response to a skin commensal. Cell Rep. 2022 05 31; 39(9):110891.
Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC. PMID: 35649365; PMCID: PMC9248974.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Early life host-microbe interactions in skin. Cell Host Microbe. 2022 05 11; 30(5):684-695.
Dwyer LR, Scharschmidt TC. PMID: 35550671; PMCID: PMC9178950.
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10 Fields:
Translation:
Humans
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Skin immunity: dissecting the complex biology of our body's outer barrier. Mucosal Immunol. 2022 04; 15(4):551-561.
Zhang C, Merana GR, Harris-Tryon T, Scharschmidt TC. PMID: 35361906.
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16 Fields:
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Baby's skin bacteria: first impressions are long-lasting. Trends Immunol. 2021 12; 42(12):1088-1099.
Dhariwala MO, Scharschmidt TC. PMID: 34743922; PMCID: PMC9206859.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Layilin Anchors Regulatory T Cells in Skin. J Immunol. 2021 10 01; 207(7):1763-1775.
Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD. PMID: 34470859; PMCID: PMC8489406.
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5 Fields:
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HumansAnimalsCells
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Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation. Sci Immunol. 2021 08 27; 6(62).
Moreau JM, Dhariwala MO, Gouirand V, Boda DP, Boothby IC, Lowe MM, Cohen JN, Macon CE, Leech JM, Kalekar LA, Scharschmidt TC, Rosenblum MD. PMID: 34452925; PMCID: PMC8958044.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
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Elucidating the Role of the Skin Barrier Protein Filaggrin in the Adaptive Immune Response to Commensals. The FASEB Journal. 2021 May 14; 35(S1).
Gonzalez GJ, Scharschmidt ST. .
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Hair of the mouse: A skin bacteria "cocktail" gets follicles back on their feet. Cell Host Microbe. 2021 05 12; 29(5):742-744.
Gonzalez JR, Merana GR, Scharschmidt TC. PMID: 33984276.
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AnimalsCells
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002 Colitis alters the antigen-specific response to skin commensal bacteria and predisposes to neutrophilic skin inflammation. Journal of Investigative Dermatology. 2021 May 1; 141(5):s1.
Merana MG, Dhariwala DM, Scharschmidt ST. .
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Colitis alters the antigen-specific response to skin commensal bacteria and predisposes to neutrophilic skin inflammation. The Journal of Immunology. 2021 May 1; 206(1_Supplement):16.28-16.28.
Merana MG, Dhariwala DM, Dwyer DL, Scharschmidt ST. .
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Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020 11 17; 1(8):100132.
Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC. PMID: 33294857; PMCID: PMC7691438.
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12 Fields:
Translation:
HumansCells
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MAIT cells are imprinted by the microbiota in early life and promote tissue repair. The Journal of Immunology. 2020 May 1; 204(1_Supplement):84.2-84.2.
Constantinides CM, Link LV, Tamoutounour TS, Wong WA, Perez-Chaparro PP, Han HS, Chen CY, Li LK, Farhat FS, Weckel WA, Krishnamurthy KS, Vujkovic-Cvijin VI, Linehan LJ, Bouladoux BN, Merrill ME, Roy RS, Cua CD, Adams AE, Bhandoola BA, Scharschmidt ST, Aubé AJ, Fischbach FM, Belkaid BY. .
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Atlas of atopic dermatitis. J Allergy Clin Immunol. 2020 06; 145(6):1558-1559.
Boothby IC, Gonzalez JR, Scharschmidt TC. PMID: 32344054.
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HumansCells
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Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. JCI Insight. 2019 12 19; 4(24).
Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD. PMID: 31852848; PMCID: PMC6975275.
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40 Fields:
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HumansAnimalsCells
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Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria. Cell Host Microbe. 2019 12 11; 26(6):795-809.e5.
Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC. PMID: 31784259; PMCID: PMC6989301.
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36 Fields:
Translation:
AnimalsCells
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MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Science. 2019 10 25; 366(6464).
Constantinides MG, Link VM, Tamoutounour S, Wong AC, Perez-Chaparro PJ, Han SJ, Chen YE, Li K, Farhat S, Weckel A, Krishnamurthy SR, Vujkovic-Cvijin I, Linehan JL, Bouladoux N, Merrill ED, Roy S, Cua DJ, Adams EJ, Bhandoola A, Scharschmidt TC, Aubé J, Fischbach MA, Belkaid Y. PMID: 31649166; PMCID: PMC7603427.
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222 Fields:
Translation:
HumansAnimalsCells
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Antibiotics for Acne-A Pilot Study of Collateral Damage to the Skin Microbiome. JAMA Dermatol. 2019 04 01; 155(4):419-421.
Scharschmidt TC. PMID: 30758480.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells. Sci Immunol. 2018 12 21; 3(30).
Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD. PMID: 30578350.
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21 Fields:
Translation:
AnimalsCells
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The microbiome in patients with atopic dermatitis. J Allergy Clin Immunol. 2019 01; 143(1):26-35.
Paller AS, Kong HH, Seed P, Naik S, Scharschmidt TC, Gallo RL, Luger T, Irvine AD. PMID: 30476499; PMCID: PMC7163929.
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PubMed Mentions:
176 Fields:
Translation:
HumansCells
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Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization. Microbiome. 2018 09 05; 6(1):154.
Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W. PMID: 30185226; PMCID: PMC6125946.
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PubMed Mentions:
119 Fields:
Translation:
HumansCells
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Skin Commensal Antigens: Taking the Road Less Traveled. Trends Immunol. 2018 04; 39(4):259-261.
Dhariwala MO, Scharschmidt TC. PMID: 29478772; PMCID: PMC5880706.
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Cells
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Fighting staph: Not child’s play. Science Translational Medicine. 2018 Jan 17; 10(424):eaar7518.
Scharschmidt ST. .
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Successful treatment of mucous membrane pemphigoid with bortezomib. JAAD Case Rep. 2018 Jan; 4(1):81-83.
Saeed L, Schmidt TH, Gensler LS, Gross AJ, Fox LP, Scharschmidt TC, Gaensler K, Naik H, Rosenblum MA, Shinkai K. PMID: 29387757; PMCID: PMC5771728.
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PubMed Mentions:
3
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S. aureus
induces IL-36 to start the itch. Science Translational Medicine. 2017 Nov 29; 9(418):eaar2445.
Scharschmidt ST. .
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Growing good bugs with mom’s milk. Science Translational Medicine. 2017 Oct 18; 9(412):eaap8172.
Scharschmidt ST. .
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ILC
regs
: The new kid in class. Science Translational Medicine. 2017 Sep 6; 9(406):eaao6121.
Scharschmidt ST. .
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Interferon with antitumor immunity. Science Translational Medicine. 2017 Jul 26; 9(400):eaao0976.
Scharschmidt ST. .
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Skin Dysbiosis Goes "Off-Leish". Cell Host Microbe. 2017 Jul 12; 22(1):1-3.
Scharschmidt TC. PMID: 28704646.
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HumansAnimalsCells
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A vitamin to D-crease sunburn. Sci Transl Med. 2017 06 14; 9(394).
Scharschmidt TC. PMID: 28615360.
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Translation:
Humans
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Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell. 2017 Jun 01; 169(6):1119-1129.e11.
Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. PMID: 28552347; PMCID: PMC5504703.
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PubMed Mentions:
292 Fields:
Translation:
HumansAnimalsCells
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Measuring inflammation in IBD with an OSM-ostat. Sci Transl Med. 2017 05 03; 9(388).
Scharschmidt TC. PMID: 28469037.
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HumansCells
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Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin. Cell Host Microbe. 2017 Apr 12; 21(4):467-477.e5.
Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD. PMID: 28343820; PMCID: PMC5516645.
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PubMed Mentions:
113 Fields:
Translation:
AnimalsCells
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When TLRs fail, IgG has your back. Sci Transl Med. 2017 03 22; 9(382).
Scharschmidt TC. PMID: 28330862.
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Humans
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Establishing Tolerance to Commensal Skin Bacteria: Timing Is Everything. Dermatol Clin. 2017 Jan; 35(1):1-9.
Scharschmidt TC. PMID: 27890233; PMCID: PMC5130113.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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014 Commensal microbes augment expression of the hair follicle chemokine Ccl20 to facilitate accumulation of Tregs in neonatal skin. Journal of Investigative Dermatology. 2016 May 1; 136(5):s3.
Scharschmidt ST, Vasquez VK, Pauli PM, Truong TH, Sonnenburg SJ, Millar MS, Rosenblum RM. .
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Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing. J Immunol. 2016 Mar 01; 196(5):2010-4.
Nosbaum A, Prevel N, Truong HA, Mehta P, Ettinger M, Scharschmidt TC, Ali NH, Pauli ML, Abbas AK, Rosenblum MD. PMID: 26826250; PMCID: PMC4761457.
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PubMed Mentions:
196 Fields:
Translation:
AnimalsCells
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A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity. 2015 Nov 17; 43(5):1011-21.
Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD. PMID: 26588783; PMCID: PMC4654993.
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PubMed Mentions:
241 Fields:
Translation:
AnimalsCells
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Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid mediated. J Invest Dermatol. 2014 Dec; 134(12):2890-2897.
Lin TK, Man MQ, Santiago JL, Scharschmidt TC, Hupe M, Martin-Ezquerra G, Youm JK, Zhai Y, Trullas C, Feingold KR, Elias PM. PMID: 24991965; PMCID: PMC4227540.
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PubMed Mentions:
13 Fields:
Translation:
Animals
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What Lives On Our Skin: Ecology, Genomics and Therapeutic Opportunities Of the Skin Microbiome. Drug Discov Today Dis Mech. 2013 Dec 01; 10(3-4).
Scharschmidt TC, Fischbach MA. PMID: 24273587; PMCID: PMC3833721.
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PubMed Mentions:
80
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Neurogenic rosacea: a distinct clinical subtype requiring a modified approach to treatment. Arch Dermatol. 2011 Jan; 147(1):123-6.
Scharschmidt TC, Yost JM, Truong SV, Steinhoff M, Wang KC, Berger TG. PMID: 21242409; PMCID: PMC3692271.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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Epidermal barrier dysfunction in non-atopic HIV: evidence for an "inside-to-outside" pathogenesis. J Invest Dermatol. 2010 Apr; 130(4):1185-8.
Gunathilake R, Schmuth M, Scharschmidt TC, Gruber R, Grabher D, Leslie KS, Maurer TA, Mauro TM, Elias PM. PMID: 19924137; PMCID: PMC4548930.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol. 2009 Sep; 124(3):496-506, 506.e1-6.
Scharschmidt TC, Man MQ, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, Silva KA, Mauro TM, Hupe M, Cho S, Wu Y, Celli A, Schmuth M, Feingold KR, Elias PM. PMID: 19733297; PMCID: PMC2881668.
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PubMed Mentions:
86 Fields:
Translation:
Animals
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Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota. J Invest Dermatol. 2009 Oct; 129(10):2435-42.
Scharschmidt TC, List K, Grice EA, Szabo R, NISC Comparative Sequencing Program, Renaud G, Lee CC, Wolfsberg TG, Bugge TH, Segre JA. PMID: 19387477; PMCID: PMC2791707.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
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Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis. J Invest Dermatol. 2009 Jul; 129(7):1824-35.
Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM. PMID: 19177139; PMCID: PMC2695850.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Modeling atopic dermatitis with increasingly complex mouse models. J Invest Dermatol. 2008 May; 128(5):1061-4.
Scharschmidt TC, Segre JA. PMID: 18408744; PMCID: PMC3523690.
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PubMed Mentions:
13 Fields:
Translation:
Animals
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Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem. 2007 Dec 14; 282(50):36714-23.
List K, Currie B, Scharschmidt TC, Szabo R, Shireman J, Molinolo A, Cravatt BF, Segre J, Bugge TH. PMID: 17940283.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Clinical trial design issues raised during recombinant DNA advisory committee review of gene transfer protocols. Hum Gene Ther. 2006 Apr; 17(4):448-54.
Scharschmidt T, Lo B. PMID: 16610932.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Clinical Trial Design Issues Raised During Recombinant DNA Advisory Committee Review of Gene Transfer Protocols. Human Gene Therapy. 2006 Mar 1; 0(0):060301061832002.
Scharschmidt ST, Lo LB. .
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Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens. J Biol Chem. 2001 May 25; 276(21):17808-14.
An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC. PMID: 11279159.
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PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells