Yvonne Kapila, DDS, PhD

SchoolUCSF School of Dentistry
DepartmentOrofacial Sciences
Address513 Parnassus Avenue
San Francisco CA 94117
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    Collapse Research Activities and Funding
    Oral Treponema Surface Proteins: Host Cell Interactions
    NIH/NIDCR R01DE025225Jul 1, 2015 - May 31, 2020
    Role: Co-Principal Investigator
    Biomarkers of Aggressive Oral Cancer
    NIH/NIDCR R56DE023333Sep 25, 2013 - Aug 31, 2015
    Role: Principal Investigator
    NIH/NIDCR R01DE014429Sep 15, 2004 - Jun 30, 2010
    Role: Principal Investigator
    Fibronectin Regulation of Anoikis
    NIH/NIDCR R56DE014429Dec 1, 2001 - Apr 30, 2012
    Role: Principal Investigator
    Apoptosis Regulated by Fibronectin Signaling Pathways
    NIH/NIDCR R01DE013725Apr 1, 2000 - Sep 30, 2011
    Role: Principal Investigator
    NIH/NIDCR K15DE000344Dec 15, 1993 - Dec 14, 1998
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lin GH, Kapila Y, Wang HL. Parameters to Define Peri-implantitis: A Review And A Proposed Multi-Domain Scale. J Oral Implantol. 2017 Sep 05. PMID: 28873021.
      View in: PubMed
    2. Shin JM, Luo T, Kamarajan P, Fenno JC, Rickard AH, Kapila YL. Microbial Communities Associated with Primary and Metastatic Head and Neck Squamous Cell Carcinoma - A High Fusobacterial and Low Streptococcal Signature. Sci Rep. 2017 Aug 30; 7(1):9934. PMID: 28855542.
      View in: PubMed
    3. Kajwadkar R, Shin JM, Lin GH, Fenno JC, Rickard AH, Kapila YL. High-purity Nisin Alone or in Combination with Sodium Hypochlorite Is Effective against Planktonic and Biofilm Populations of Enterococcus faecalis. J Endod. 2017 Jun; 43(6):989-994. PMID: 28457635.
      View in: PubMed
    4. Kamarajan P, Rajendiran TM, Kinchen J, Bermúdez M, Danciu T, Kapila YL. Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase. J Proteome Res. 2017 Mar 03; 16(3):1315-1326. PMID: 28168879.
      View in: PubMed
    5. Maska B, Lin GH, Othman A, Behdin S, Travan S, Benavides E, Kapila Y. Dental implants and grafting success remain high despite large variations in maxillary sinus mucosal thickening. Int J Implant Dent. 2017 Dec; 3(1):1. PMID: 28101784.
      View in: PubMed
    6. Shin JM, Kamarajan P, Fenno JC, Rickard AH, Kapila YL. Metabolomics of Head and Neck Cancer: A Mini-Review. Front Physiol. 2016; 7:526. PMID: 27877135.
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    7. Dabiri D, Halubai S, Layher M, Klausner C, Makhoul H, Lin GH, Eckert G, Abuhussein H, Kamarajan P, Kapila Y. The Role of Apoptotic Factors in Assessing Progression of Periodontal Disease. Int J Dent Oral Sci. 2016 Sep; 3(9):318-325. PMID: 28540365.
      View in: PubMed
    8. Dabiri D, Fontana M, Kapila Y, Eckert G, Sokal-Gutierrez K. Community-based assessment and intervention for early childhood caries in rural El Salvador. Int Dent J. 2016 Aug; 66(4):221-8. PMID: 27080395.
      View in: PubMed
    9. Shin JM, Gwak JW, Kamarajan P, Fenno JC, Rickard AH, Kapila YL. Biomedical applications of nisin. J Appl Microbiol. 2016 Jun; 120(6):1449-65. PMID: 26678028; PMCID: PMC4866897 [Available on 06/01/17].
    10. Alhazzazi TY, Kamarajan P, Xu Y, Ai T, Chen L, Verdin E, Kapila Y. A Novel Sirtuin-3 Inhibitor, LC-0296, Inhibits Cell Survival and Proliferation, and Promotes Apoptosis of Head and Neck Cancer Cells. Anticancer Res. 2016 Jan; 36(1):49-60. PMID: 26722027.
      View in: PubMed
    11. Godovikova V, Goetting-Minesky MP, Shin JM, Kapila YL, Rickard AH, Fenno JC. A Modified Shuttle Plasmid Facilitates Expression of a Flavin Mononucleotide-Based Fluorescent Protein in Treponema denticola ATCC 35405. Appl Environ Microbiol. 2015 Sep; 81(18):6496-504. PMID: 26162875; PMCID: PMC4542240.
    12. Crouch S, Farkash J, Branch A, Vasconcellos L, Veronesi G, Kapila YL. To Brazil and Back: An International Dental Student Exchange Program. J Mich Dent Assoc. 2015 Jul; 97(7):40, 42-3. PMID: 26292504.
      View in: PubMed
    13. Kamarajan P, Hayami T, Matte B, Liu Y, Danciu T, Ramamoorthy A, Worden F, Kapila S, Kapila Y. Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival. PLoS One. 2015; 10(7):e0131008. PMID: 26132406; PMCID: PMC4489501.
    14. Shin JM, Ateia I, Paulus JR, Liu H, Fenno JC, Rickard AH, Kapila YL. Antimicrobial nisin acts against saliva derived multi-species biofilms without cytotoxicity to human oral cells. Front Microbiol. 2015; 6:617. PMID: 26150809; PMCID: PMC4471743.
    15. Joo NE, Miao D, Bermúdez M, Stallcup WB, Kapila YL. Shedding of NG2 by MMP-13 attenuates anoikis. DNA Cell Biol. 2014 Dec; 33(12):854-62. PMID: 25166220; PMCID: PMC4248241.
    16. Miao D, Godovikova V, Qian X, Seshadrinathan S, Kapila YL, Fenno JC. Treponema denticola upregulates MMP-2 activation in periodontal ligament cells: interplay between epigenetics and periodontal infection. Arch Oral Biol. 2014 Oct; 59(10):1056-64. PMID: 24973519; PMCID: PMC4120104.
    17. Lesch A, Pisano J, Kapila YL. The student perspective: international exchange programs. J Mich Dent Assoc. 2014 Jun; 96(6):33-4. PMID: 25007466.
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    18. Tsai CY, Garaicoa-Pazmino C, Mori K, Benavides E, Kaigler D, Kapila Y. Implant success remains high despite grafting voids in the maxillary sinus. Clin Oral Implants Res. 2015 Apr; 26(4):447-53. PMID: 24720484.
      View in: PubMed
    19. Abuhussein H, Bashutski JD, Dabiri D, Halubai S, Layher M, Klausner C, Makhoul H, Kapila Y. The role of factors associated with apoptosis in assessing periodontal disease status. J Periodontol. 2014 Aug; 85(8):1086-95. PMID: 24359166.
      View in: PubMed
    20. Kamarajan P, Shin JM, Qian X, Matte B, Zhu JY, Kapila YL. ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC. Cancer Med. 2013 Dec; 2(6):793-802. PMID: 24403253; PMCID: PMC3892384.
    21. Alhazzazi TY, Kamarajan P, Verdin E, Kapila Y. Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer. 2013 Mar; 4(3-4):164-71. PMID: 24020007; PMCID: PMC3764471.
    22. Makhoul H, Bashutski J, Halubai S, Dabiri D, Benavides E, Kapila YL. Apoptotic activity of gingival crevicular fluid from localized aggressive periodontitis. J Int Acad Periodontol. 2013 Jan; 15(1):2-7. PMID: 23413626.
      View in: PubMed
    23. Joo NE, Ritchie K, Kamarajan P, Miao D, Kapila YL. Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1. Cancer Med. 2012 Dec; 1(3):295-305. PMID: 23342279; PMCID: PMC3544465.
    24. Tripathi P, Kamarajan P, Somashekar BS, MacKinnon N, Chinnaiyan AM, Kapila YL, Rajendiran TM, Ramamoorthy A. Delineating metabolic signatures of head and neck squamous cell carcinoma: phospholipase A2, a potential therapeutic target. Int J Biochem Cell Biol. 2012 Nov; 44(11):1852-61. PMID: 22743333; PMCID: PMC3455146.
    25. Kamarajan P, Alhazzazi TY, Danciu T, D'silva NJ, Verdin E, Kapila Y. Receptor-interacting protein (RIP) and Sirtuin-3 (SIRT3) are on opposite sides of anoikis and tumorigenesis. Cancer. 2012 Dec 01; 118(23):5800-10. PMID: 22674009; PMCID: PMC3443499.
    26. Somashekar BS, Kamarajan P, Danciu T, Kapila YL, Chinnaiyan AM, Rajendiran TM, Ramamoorthy A. Magic angle spinning NMR-based metabolic profiling of head and neck squamous cell carcinoma tissues. J Proteome Res. 2011 Nov 04; 10(11):5232-41. PMID: 21961579; PMCID: PMC3208743.
    27. Alhazzazi TY, Kamarajan P, Verdin E, Kapila Y. SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta. 2011 Aug; 1816(1):80-8. PMID: 21586315; PMCID: PMC3129516.
    28. Hayami T, Kapila YL, Kapila S. Divergent upstream osteogenic events contribute to the differential modulation of MG63 cell osteoblast differentiation by MMP-1 (collagenase-1) and MMP-13 (collagenase-3). Matrix Biol. 2011 May; 30(4):281-9. PMID: 21539914; PMCID: PMC3116144.
    29. Marchesan JT, Scanlon CS, Soehren S, Matsuo M, Kapila YL. Implications of cultured periodontal ligament cells for the clinical and experimental setting: a review. Arch Oral Biol. 2011 Oct; 56(10):933-43. PMID: 21470594; PMCID: PMC3132241.
    30. Scanlon C, Marchesan J, Soehren S, Matsuo M, Kapila Y. Capturing the regenerative potential of periodontal ligament fibroblasts. J Stem Cells Regen Med. 2011; 7(1):54-6. PMID: 21738334.
      View in: PubMed
    31. Alhazzazi TY, Kamarajan P, Joo N, Huang JY, Verdin E, D'Silva NJ, Kapila Y. Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer. 2011 Apr 15; 117(8):1670-8. PMID: 21472714; PMCID: PMC3117020.
    32. Miao D, Fenno JC, Timm JC, Joo NE, Kapila YL. The Treponema denticola chymotrypsin-like protease dentilisin induces matrix metalloproteinase-2-dependent fibronectin fragmentation in periodontal ligament cells. Infect Immun. 2011 Feb; 79(2):806-11. PMID: 21115719; PMCID: PMC3028863.
    33. Bunek J, Kamarajan P, Kapila YL. Anoikis mediators in oral squamous cell carcinoma. Oral Dis. 2011 May; 17(4):355-61. PMID: 21114588; PMCID: PMC3072433.
    34. Pirih FQ, Michalski MN, Cho SW, Koh AJ, Berry JE, Ghaname E, Kamarajan P, Bonnelye E, Ross CW, Kapila YL, Jurdic P, McCauley LK. Parathyroid hormone mediates hematopoietic cell expansion through interleukin-6. PLoS One. 2010 Oct 27; 5(10):e13657. PMID: 21048959; PMCID: PMC2965090.
    35. Ghosh A, Chen TC, Kapila YL. Anoikis triggers Mdm2-dependent p53 degradation. Mol Cell Biochem. 2010 Oct; 343(1-2):201-9. PMID: 20577896; PMCID: PMC2943547.
    36. Kamarajan P, Garcia-Pardo A, D'Silva NJ, Kapila YL. The CS1 segment of fibronectin is involved in human OSCC pathogenesis by mediating OSCC cell spreading, migration, and invasion. BMC Cancer. 2010 Jun 25; 10:330. PMID: 20579373; PMCID: PMC3146068.
    37. Paula-Silva FW, Ghosh A, Arzate H, Kapila S, da Silva LA, Kapila YL. Calcium hydroxide promotes cementogenesis and induces cementoblastic differentiation of mesenchymal periodontal ligament cells in a CEMP1- and ERK-dependent manner. Calcif Tissue Int. 2010 Aug; 87(2):144-57. PMID: 20440482.
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    38. Ghosh A, Joo NE, Chen TC, Kapila YL. Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells. J Periodontal Res. 2010 Aug; 45(4):481-7. PMID: 20337881; PMCID: PMC2894266.
    39. Paula-Silva FW, da Silva LA, Kapila YL. Matrix metalloproteinase expression in teeth with apical periodontitis is differentially modulated by the modality of root canal treatment. J Endod. 2010 Feb; 36(2):231-7. PMID: 20113780; PMCID: PMC2818380.
    40. Joseph J, Kapila YL, Hayami T, Kapila S. Disease-associated extracellular matrix suppresses osteoblastic differentiation of human periodontal ligament cells via MMP-1. Calcif Tissue Int. 2010 Feb; 86(2):154-62. PMID: 19953231; PMCID: PMC3152822.
    41. Kamarajan P, Bunek J, Lin Y, Nunez G, Kapila YL. Receptor-interacting protein shuttles between cell death and survival signaling pathways. Mol Biol Cell. 2010 Feb 01; 21(3):481-8. PMID: 19955213; PMCID: PMC2814792.
    42. Daniels TE, Kapila Y. Comments on atrophic lingual papillae and candidiasis in Sjögren syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jan; 109(1):4; author reply 4. PMID: 19828340.
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    43. de Paula-Silva FW, D'Silva NJ, da Silva LA, Kapila YL. High matrix metalloproteinase activity is a hallmark of periapical granulomas. J Endod. 2009 Sep; 35(9):1234-42. PMID: 19720222; PMCID: PMC2736957.
    44. Xu J, Wang W, Kapila Y, Lotz J, Kapila S. Multiple differentiation capacity of STRO-1+/CD146+ PDL mesenchymal progenitor cells. Stem Cells Dev. 2009 Apr; 18(3):487-96. PMID: 18593336; PMCID: PMC2702120.
    45. Paula-Silva FW, Ghosh A, Silva LA, Kapila YL. TNF-alpha promotes an odontoblastic phenotype in dental pulp cells. J Dent Res. 2009 Apr; 88(4):339-44. PMID: 19407154; PMCID: PMC3144054.
    46. Ghosh A, Park JY, Fenno C, Kapila YL. Porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-Jun N-terminal kinase 1-mediated nitric oxide generation and cell death. Infect Immun. 2008 Dec; 76(12):5514-23. PMID: 18838522; PMCID: PMC2583576.
    47. Hayami T, Kapila YL, Kapila S. MMP-1 (collagenase-1) and MMP-13 (collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells. Matrix Biol. 2008 Oct; 27(8):682-92. PMID: 18755271; PMCID: PMC2683744.
    48. Joo NE, Watanabe T, Chen C, Chekenya M, Stallcup WB, Kapila YL. NG2, a novel proapoptotic receptor, opposes integrin alpha4 to mediate anoikis through PKCalpha-dependent suppression of FAK phosphorylation. Cell Death Differ. 2008 May; 15(5):899-907. PMID: 18292781; PMCID: PMC3940336.
    49. Kamarajan P, Kapila YL. An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK. Apoptosis. 2007 Dec; 12(12):2221-31. PMID: 17879163.
      View in: PubMed
    50. Hayami T, Zhang Q, Kapila Y, Kapila S. Dexamethasone's enhancement of osteoblastic markers in human periodontal ligament cells is associated with inhibition of collagenase expression. Bone. 2007 Jan; 40(1):93-104. PMID: 16934542.
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    51. Dai R, Iwama A, Wang S, Kapila YL. Disease-associated fibronectin matrix fragments trigger anoikis of human primary ligament cells: p53 and c-myc are suppressed. Apoptosis. 2005 May; 10(3):503-12. PMID: 15909113.
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    52. Tafolla E, Wang S, Wong B, Leong J, Kapila YL. JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53. J Biol Chem. 2005 May 20; 280(20):19992-9. PMID: 15778501.
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    53. Lu H, Jin D, Kapila YL. Application of laser capture microdissection to phage display peptide library screening. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Dec; 98(6):692-7. PMID: 15583542.
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    54. Zhang Y, Lu H, Dazin P, Kapila Y. Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. J Biol Chem. 2004 Nov 12; 279(46):48342-9. PMID: 15331608.
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    55. Zhang Y, Lu H, Dazin P, Kapila Y. Functional differences between integrin alpha4 and integrins alpha5/alphav in modulating the motility of human oral squamous carcinoma cells in response to the V region and heparin-binding domain of fibronectin. Exp Cell Res. 2004 Apr 15; 295(1):48-58. PMID: 15051489.
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    56. Jee SW, Wang S, Kapila YL. Specific pro-apoptotic fibronectin fragments modulate proteinase expression in periodontal ligament cells. J Periodontol. 2004 Apr; 75(4):523-30. PMID: 15152815.
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    57. Iwama A, Nishigaki N, Nakamura K, Imaizumi I, Shibata N, Yamasaki M, Nakamura H, Kameyama Y, Kapila Y. The effect of high sugar intake on the development of periradicular lesions in rats with type 2 diabetes. J Dent Res. 2003 Apr; 82(4):322-5. PMID: 12651940.
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    58. Shiga M, Kapila Y, Zhang Q, Hayami T, Kapila S. Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: potential association between collagenase expression and changes in alkaline phosphatase phenotype. J Bone Miner Res. 2003 Jan; 18(1):67-77. PMID: 12510807.
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    59. Huynh QN, Wang S, Tafolla E, Gansky SA, Kapila S, Armitage GC, Kapila Y. Specific fibronectin fragments as markers of periodontal disease status. J Periodontol. 2002 Oct; 73(10):1101-10. PMID: 12416766.
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    60. Kapila YL, Wang S, Dazin P, Tafolla E, Mass MJ. The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells. J Biol Chem. 2002 Mar 08; 277(10):8482-91. PMID: 11751853.
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    61. Kapila Y, Doan D, Tafolla E, Fletterick R. Three-dimensional structural analysis of fibronectin heparin-binding domain mutations. J Cell Biochem Suppl. 2001; Suppl 36:156-61. PMID: 11455580.
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    62. Hu B, Kapila YL, Buddhikot M, Shiga M, Kapila S. Coordinate induction of collagenase-1, stromelysin-1 and urokinase plasminogen activator (uPA) by the 120-kDa cell-binding fibronectin fragment in fibrocartilaginous cells: uPA contributes to activation of procollagenase-1. Matrix Biol. 2000 Dec; 19(7):657-69. PMID: 11102755.
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    63. Kapila YL, Wang S, Johnson PW. Mutations in the heparin binding domain of fibronectin in cooperation with the V region induce decreases in pp125(FAK) levels plus proteoglycan-mediated apoptosis via caspases. J Biol Chem. 1999 Oct 22; 274(43):30906-13. PMID: 10521484.
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    64. Kapila Y, Lancero H, Johnson PW. The response of periodontal ligament cells to fibronectin. J Periodontol. 1998 Sep; 69(9):1008-19. PMID: 9776029.
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    65. Kapila YL, Niu J, Johnson PW. The high affinity heparin-binding domain and the V region of fibronectin mediate invasion of human oral squamous cell carcinoma cells in vitro. J Biol Chem. 1997 Jul 25; 272(30):18932-8. PMID: 9228073.
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    66. Kapila YL, Kashani H. Cocaine-associated rapid gingival recession and dental erosion. A case report. J Periodontol. 1997 May; 68(5):485-8. PMID: 9182745.
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    67. Kapila YL, Kapila S, Johnson PW. Fibronectin and fibronectin fragments modulate the expression of proteinases and proteinase inhibitors in human periodontal ligament cells. Matrix Biol. 1996 Sep; 15(4):251-61. PMID: 8892225.
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