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Ralph Marcucio, PhD

Title(s)Professor, Orthopaedic Surgery
SchoolSchool of Medicine
Phone628-206-5366
ORCID ORCID Icon0000-0002-0537-818X Additional info
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    Transcriptional regulatory landscapes underlying FEZ Formation
    NIH/NIDCR R01DE028324Mar 11, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Understanding the Forces that Shape the Face
    NIH/NIDCR R21DE028198Sep 15, 2018 - Aug 31, 2020
    Role: Principal Investigator
    The role of continuous phenotypic variation in structural defects of the face
    NIH/NIDCR R01DE019638Jan 1, 2016 - Feb 28, 2015
    Role: Principal Investigator
    Effects of Aging on Macrophages and Bone Regeneration
    NIH/NIA R01AG046282Sep 30, 2013 - May 31, 2017
    Role: Principal Investigator
    Developmental mechanisms underlying genotype-phenotype correlations
    NIH/NIDCR R01DE021708Apr 27, 2011 - Mar 31, 2016
    Role: Principal Investigator
    Molecular Basis of Tissue Interactions that Regulate Craniofacial Development
    NIH/NIDCR R01DE018234Jun 1, 2007 - May 31, 2012
    Role: Principal Investigator
    BMP-Mediated Tissue Interactions that Pattern the Face
    NIH/NIDCR R03DE015901Jan 1, 2005 - Dec 31, 2007
    Role: Principal Investigator
    CELL DEATH IN EMBRYONIC HEAD MUSCLES
    NIH/NIDCR F32DE005683Apr 1, 1997
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Br J Anaesth. 2020 09; 125(3):298-307. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M. PMID: 32624183.
      View in: PubMed   Mentions:    Fields:    
    2. Biomedical research models in the science of fracture healing - Pitfalls & promises. Injury. 2020 Jun 15. Marmor MT, Dailey H, Marcucio R, Hunt AC. PMID: 32591215.
      View in: PubMed   Mentions:    Fields:    
    3. Facial shape and allometry quantitative trait locus intervals in the Diversity Outbred mouse are enriched for known skeletal and facial development genes. PLoS One. 2020; 15(6):e0233377. Katz DC, Aponte JD, Liu W, Green RM, Mayeux JM, Pollard KM, Pomp D, Munger SC, Murray SA, Roseman CC, Percival CJ, Cheverud J, Marcucio RS, Hallgrímsson B. PMID: 32502155.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. miR-199 Family Contributes to Regulation of Sonic Hedgehog Expression During Craniofacial Development. Dev Dyn. 2020 May 11. Richbourg HA, Hu DP, Xu Y, Barczak AJ, Marcucio RS. PMID: 32391617.
      View in: PubMed   Mentions:    Fields:    
    5. A novel mouse model to study fracture healing of the proximal femur. J Orthop Res. 2020 Mar 31. Haffner-Luntzer M, Weber B, Lam C, Fischer V, Lackner I, Ignatius A, Kalbitz M, Marcucio RS, Miclau T. PMID: 32232999.
      View in: PubMed   Mentions: 1     Fields:    
    6. Age-related changes to macrophages are detrimental to fracture healing in mice. Aging Cell. 2020 03; 19(3):e13112. Clark D, Brazina S, Yang F, Hu D, Hsieh CL, Niemi EC, Miclau T, Nakamura MC, Marcucio R. PMID: 32096907.
      View in: PubMed   Mentions:    Fields:    
    7. SATB1 establishes ameloblast cell polarity and regulates directional amelogenin secretion for enamel formation. BMC Biol. 2019 12 13; 17(1):104. Zhang Y, Zheng L, Le M, Nakano Y, Chan B, Huang Y, Torbaty PM, Kohwi Y, Marcucio R, Habelitz S, Den Besten PK, Kohwi-Shigematsu T. PMID: 31830989.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. AGE-RELATED CHANGES TO MACROPHAGES AFFECT FRACTURE HEALING. Innovation in Aging. 2019 Nov 8; 3(Supplement_1):s83-s83. Daniel Clark, Theodore Miclau, Mary Nakamura, Ralph Marcucio. .
      View in: Publisher Site   Mentions:
    9. Integration and the Developmental Genetics of Allometry. Integr Comp Biol. 2019 11 01; 59(5):1369-1381. Hallgrímsson B, Katz DC, Aponte JD, Larson JR, Devine J, Gonzalez PN, Young NM, Roseman CC, Marcucio RS. PMID: 31199435.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    10. Nonlinear gene expression-phenotype relationships contribute to variation and clefting in the A/WySn mouse. Dev Dyn. 2019 12; 248(12):1232-1242. Green RM, Leach CL, Diewert VM, Aponte JD, Schmidt EJ, Cheverud JM, Roseman CC, Young NM, Marcucio RS, Hallgrimsson B. PMID: 31469941.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Differential fracture response to traumatic brain injury suggests dominance of neuroinflammatory response in polytrauma. Sci Rep. 2019 08 21; 9(1):12199. Morioka K, Marmor Y, Sacramento JA, Lin A, Shao T, Miclau KR, Clark DR, Beattie MS, Marcucio RS, Miclau T, Ferguson AR, Bresnahan JC, Bahney CS. PMID: 31434912.
      View in: PubMed   Mentions: 1     Fields:    
    12. Fracture repair in the elderly: Clinical and experimental considerations. Injury. 2019 Jun; 50 Suppl 1:S62-S65. Meinberg EG, Clark D, Miclau KR, Marcucio R, Miclau T. PMID: 31130210.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via ß-AR signaling. Proc Natl Acad Sci U S A. 2019 04 23; 116(17):8615-8622. Haffner-Luntzer M, Foertsch S, Fischer V, Prystaz K, Tschaffon M, Mödinger Y, Bahney CS, Marcucio RS, Miclau T, Ignatius A, Reber SO. PMID: 30948630.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. The Society for Craniofacial Genetics and Developmental Biology 41st Annual Meeting. Am J Med Genet A. 2019 05; 179(5):864-869. Taneyhill LA, Moody SA, Cox T, Klein OD, Marcucio R, Schneider RA, Trainor PA. PMID: 30793834.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    15. Cellular biology of fracture healing. J Orthop Res. 2019 01; 37(1):35-50. Bahney CS, Zondervan RL, Allison P, Theologis A, Ashley JW, Ahn J, Miclau T, Marcucio RS, Hankenson KD. PMID: 30370699.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. The developmental-genetics of canalization. Semin Cell Dev Biol. 2019 04; 88:67-79. Hallgrimsson B, Green RM, Katz DC, Fish JL, Bernier FP, Roseman CC, Young NM, Cheverud JM, Marcucio RS. PMID: 29782925.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    17. Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering. Front Bioeng Biotechnol. 2018; 6:58. Wong SA, Rivera KO, Miclau T, Alsberg E, Marcucio RS, Bahney CS. PMID: 29868574.
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    18. The Society for Craniofacial Genetics and Developmental Biology 40th annual meeting. Am J Med Genet A. 2018 05; 176(5):1270-1273. Gammill L, Cox T, Moody S, Taneyhill L, Trainor P, Marcucio R. PMID: 29681098.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    19. Simulation enabled search for explanatory mechanisms of the fracture healing process. PLoS Comput Biol. 2018 02; 14(2):e1005980. Kennedy RC, Marmor M, Marcucio R, Hunt CA. PMID: 29394245.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    20. Living tissues are more than cell clusters: The extracellular matrix as a driving force in morphogenesis. Prog Biophys Mol Biol. 2018 09; 137:46-51. Linde-Medina M, Marcucio R. PMID: 29398066.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    21. Developmental constraint through negative pleiotropy in the zygomatic arch. Evodevo. 2018; 9:3. Percival CJ, Green R, Roseman CC, Gatti DM, Morgan JL, Murray SA, Donahue LR, Mayeux JM, Pollard KM, Hua K, Pomp D, Marcucio R, Hallgrímsson B. PMID: 29423138.
      View in: PubMed   Mentions:
    22. Developmental nonlinearity drives phenotypic robustness. Nat Commun. 2017 12 06; 8(1):1970. Green RM, Fish JL, Young NM, Smith FJ, Roberts B, Dolan K, Choi I, Leach CL, Gordon P, Cheverud JM, Roseman CC, Williams TJ, Marcucio RS, Hallgrímsson B. PMID: 29213092.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    23. Effects of Aging on Fracture Healing. Curr Osteoporos Rep. 2017 12; 15(6):601-608. Clark D, Nakamura M, Miclau T, Marcucio R. PMID: 29143915.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. Reverse engineering development: Crosstalk opportunities between developmental biology and tissue engineering. J Orthop Res. 2017 11; 35(11):2356-2368. Marcucio RS, Qin L, Alsberg E, Boerckel JD. PMID: 28660712.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    25. Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing? Front Cell Dev Biol. 2017; 5:45. Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T. PMID: 28523266.
      View in: PubMed   Mentions:
    26. Shaping the sound of voice. Elife. 2017 03 20; 6. Marcucio R. PMID: 28318485.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    27. Craniofacial diversification in the domestic pigeon and the evolution of the avian skull. Nat Ecol Evol. 2017 Mar 13; 1(4):95. Young NM, Linde-Medina M, Fondon JW, Hallgrímsson B, Marcucio RS. PMID: 28812673.
      View in: PubMed   Mentions: 5     Fields:    
    28. Quantifying three-dimensional morphology and RNA from individual embryos. Dev Dyn. 2017 05; 246(5):431-436. Green RM, Leach CL, Hoehn N, Marcucio RS, Hallgrímsson B. PMID: 28152580.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    29. The society for craniofacial genetics and developmental biology 39th annual meeting. Am J Med Genet A. 2017 Apr; 173(4):985-1006. Fish JL, Albertson C, Harris MP, Lozanoff S, Marcucio RS, Richtsmeier JT, Trainor PA. PMID: 28168819.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    30. Development Shapes a Consistent Inbreeding Effect in Mouse Crania of Different Line Crosses. J Exp Zool B Mol Dev Evol. 2016 12; 326(8):474-488. Pavlicev M, Mitteroecker P, Gonzalez PM, Rolian C, Jamniczky H, Villena FP, Marcucio R, Spritz R, Hallgrimsson B. PMID: 28097826.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    31. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development. 2017 01 15; 144(2):221-234. Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS. PMID: 28096214.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    32. Future Treatment Strategies for Delayed Bone Healing: An Osteoimmunologic Approach. J Am Acad Orthop Surg. 2016 Oct; 24(10):e134-5. Schmidt-Bleek K, Marcucio R, Duda G. PMID: 27579817.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    33. FGFR-associated craniosynostosis syndromes and gastrointestinal defects. Am J Med Genet A. 2016 12; 170(12):3215-3221. Hibberd CE, Bowdin S, Arudchelvan Y, Forrest CR, Brakora KA, Marcucio RS, Gong SG. PMID: 27481450.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    34. Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel. J Evol Biol. 2016 Sep; 29(9):1737-51. Gonzalez PN, Pavlicev M, Mitteroecker P, Pardo-Manuel de Villena F, Spritz RA, Marcucio RS, Hallgrímsson B. PMID: 27234063.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    35. The society for craniofacial genetics and developmental biology 38th annual meeting. Am J Med Genet A. 2016 07; 170(7):1732-53. Taneyhill LA, Hoover-Fong J, Lozanoff S, Marcucio R, Richtsmeier JT, Trainor PA. PMID: 27102868.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Facial surface morphology predicts variation in internal skeletal shape. Am J Orthod Dentofacial Orthop. 2016 Apr; 149(4):501-8. Young NM, Sherathiya K, Gutierrez L, Nguyen E, Bekmezian S, Huang JC, Hallgrímsson B, Lee JS, Marcucio RS. PMID: 27021454.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    37. Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes. Tissue Eng Part A. 2016 Mar; 22(5-6):427-35. Bahney CS, Jacobs L, Tamai R, Hu D, Luan TF, Wang M, Reddy S, Park M, Limburg S, Kim HT, Marcucio R, Kuo AC. PMID: 26830207.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    38. Beyond cell proliferation in avian facial morphogenesis. Dev Dyn. 2016 Mar; 245(3):190-6. Linde-Medina M, Hallgrímsson B, Marcucio R. PMID: 26637960.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    39. Stem Cell Therapies in Orthopaedic Trauma. J Orthop Trauma. 2015 Dec; 29 Suppl 12:S24-7. Marcucio RS, Nauth A, Giannoudis PV, Bahney C, Piuzzi NS, Muschler G, Miclau T. PMID: 26584262.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    40. Tissue engineering strategies for promoting vascularized bone regeneration. Bone. 2016 Feb; 83:197-209. Almubarak S, Nethercott H, Freeberg M, Beaudon C, Jha A, Jackson W, Marcucio R, Miclau T, Healy K, Bahney C. PMID: 26608518.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    41. Morphometrics, 3D Imaging, and Craniofacial Development. Curr Top Dev Biol. 2015; 115:561-97. Hallgrimsson B, Percival CJ, Green R, Young NM, Mio W, Marcucio R. PMID: 26589938.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    42. Facial Morphogenesis: Physical and Molecular Interactions Between the Brain and the Face. Curr Top Dev Biol. 2015; 115:299-320. Marcucio R, Hallgrimsson B, Young NM. PMID: 26589930.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    43. Genetics of murine craniofacial morphology: diallel analysis of the eight founders of the Collaborative Cross. J Anat. 2016 Jan; 228(1):96-112. Percival CJ, Liberton DK, Pardo-Manuel de Villena F, Spritz R, Marcucio R, Hallgrímsson B. PMID: 26426826.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    44. Correlations Between the Morphology of Sonic Hedgehog Expression Domains and Embryonic Craniofacial Shape. Evol Biol. 2015 Sep; 42(3):379-386. Xu Q, Jamniczky H, Hu D, Green RM, Marcucio RS, Hallgrimsson B, Mio W. PMID: 26321772.
      View in: PubMed   Mentions:
    45. Signals from the brain induce variation in avian facial shape. Dev Dyn. 2015 Sep; 244(9):1133-1143. Hu D, Young NM, Xu Q, Jamniczky H, Green RM, Mio W, Marcucio RS, Hallgrimsson B. PMID: 25903813.
      View in: PubMed   Mentions: 17     Fields:    
    46. Divergence of craniofacial developmental trajectories among avian embryos. Dev Dyn. 2015 Sep; 244(9):1158-1167. Smith FJ, Percival CJ, Young NM, Hu D, Schneider RA, Marcucio RS, Hallgrimsson B. PMID: 25703037.
      View in: PubMed   Mentions: 9     Fields:    
    47. Role of muscle stem cells during skeletal regeneration. Stem Cells. 2015 May; 33(5):1501-11. Abou-Khalil R, Yang F, Lieu S, Julien A, Perry J, Pereira C, Relaix F, Miclau T, Marcucio R, Colnot C. PMID: 25594525.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    48. The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells. Acta Biomater. 2015 May; 18:100-11. Song S, Kim EJ, Bahney CS, Miclau T, Marcucio R, Roy S. PMID: 25735800.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    49. A comparative examination of odontogenic gene expression in both toothed and toothless amniotes. J Exp Zool B Mol Dev Evol. 2015 May; 324(3):255-69. Lainoff AJ, Moustakas-Verho JE, Hu D, Kallonen A, Marcucio RS, Hlusko LJ. PMID: 25678399.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    50. The multifaceted role of the vasculature in endochondral fracture repair. Front Endocrinol (Lausanne). 2015; 6:4. Bahney CS, Hu DP, Miclau T, Marcucio RS. PMID: 25699016.
      View in: PubMed   Mentions:
    51. A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face. Development. 2015 Feb 01; 142(3):567-74. Hu D, Young NM, Li X, Xu Y, Hallgrímsson B, Marcucio RS. PMID: 25605783.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    52. Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice. Dis Model Mech. 2015 Feb; 8(2):139-46. Billington CJ, Schmidt B, Marcucio RS, Hallgrimsson B, Gopalakrishnan R, Petryk A. PMID: 25468951.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    53. Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage. Dis Model Mech. 2015 Jan; 8(1):31-43. Green RM, Feng W, Phang T, Fish JL, Li H, Spritz RA, Marcucio RS, Hooper J, Jamniczky H, Hallgrímsson B, Williams T. PMID: 25381013.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    54. Let's face it--complex traits are just not that simple. PLoS Genet. 2014 Nov; 10(11):e1004724. Hallgrimsson B, Mio W, Marcucio RS, Spritz R. PMID: 25375250.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    55. Holoprosencephaly: signaling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans. Wiley Interdiscip Rev Dev Biol. 2015 Jan-Feb; 4(1):17-32. Petryk A, Graf D, Marcucio R. PMID: 25339593.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    56. Surface landmark quantification of embryonic mouse craniofacial morphogenesis. BMC Dev Biol. 2014 Jul 24; 14:31. Percival CJ, Green R, Marcucio R, Hallgrímsson B. PMID: 25059626.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    57. Biological perspectives of delayed fracture healing. Injury. 2014 Jun; 45 Suppl 2:S8-S15. Hankenson KD, Zimmerman G, Marcucio R. PMID: 24857030.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    58. Embryonic bauplans and the developmental origins of facial diversity and constraint. Development. 2014 Mar; 141(5):1059-63. Young NM, Hu D, Lainoff AJ, Smith FJ, Diaz R, Tucker AS, Trainor PA, Schneider RA, Hallgrímsson B, Marcucio RS. PMID: 24550113.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    59. Delayed bone regeneration is linked to chronic inflammation in murine muscular dystrophy. J Bone Miner Res. 2014 Feb; 29(2):304-15. Abou-Khalil R, Yang F, Mortreux M, Lieu S, Yu YY, Wurmser M, Pereira C, Relaix F, Miclau T, Marcucio RS, Colnot C. PMID: 23857747.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    60. Stem cell-derived endochondral cartilage stimulates bone healing by tissue transformation. J Bone Miner Res. 2014; 29(5):1269-82. Bahney CS, Hu DP, Taylor AJ, Ferro F, Britz HM, Hallgrimsson B, Johnstone B, Miclau T, Marcucio RS. PMID: 24259230.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    61. Modulation of macrophage activity during fracture repair has differential effects in young adult and elderly mice. J Orthop Trauma. 2014; 28 Suppl 1:S10-4. Slade Shantz JA, Yu YY, Andres W, Miclau T, Marcucio R. PMID: 24378434.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    62. Contributor contact details. Bone Substitute Biomaterials. 2014 Jan 1; xi-xiii. K.K. Mallick, S. Sprio, M. Sandri, M. Iafisco, A. Ruffini, S. Minardi, A. Tampieri, P. Bhattacharya, G.H. van Lenthe, E.B. Hunziker, T.J. Blokhuis, V. Guarino, M.G. Raucci, A. Ronca, V. Cirillo, L. Ambrosio, K.K. Mallick, J. Winnett, A. Bansiddhi, D.C. Dunand, G.C. Wang, Z.F. Lu, H. Zreiqat, C.S. Bahney, R.S. Marcucio, J. Venkatesan, S.K. Kim, L. Grøndahl, C.S. Goonasekera, K.S. Jack, S.A. Clarke, P. Walsh. .
      View in: Publisher Site   Mentions:
    63. 9 Cartilage grafts for bone repair and regeneration. Bone Substitute Biomaterials. 2014 Jan 1; 219-243. C.S. Bahney, R.S. Marcucio. .
      View in: Publisher Site   Mentions:
    64. Selective estrogen receptor modulation prevents scoliotic curve progression: radiologic and histomorphometric study on a bipedal C57Bl6 mice model. Eur Spine J. 2014 Feb; 23(2):455-62. Demirkiran G, Dede O, Yalcin N, Akel I, Marcucio R, Acaroglu E. PMID: 24136418.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    65. Quantification of shape and cell polarity reveals a novel mechanism underlying malformations resulting from related FGF mutations during facial morphogenesis. Hum Mol Genet. 2013 Dec 20; 22(25):5160-72. Li X, Young NM, Tropp S, Hu D, Xu Y, Hallgrímsson B, Marcucio RS. PMID: 23906837.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    66. Beneficial effects of oxygen- and lactate-production in scaffold designs. Bone. 2013 Nov; 57(1):324. Marcucio R, Hunt TK, Miclau T. PMID: 23895996.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    67. The effect of hypoxia on facial shape variation and disease phenotypes in chicken embryos. Dis Model Mech. 2013 Jul; 6(4):915-24. Smith F, Hu D, Young NM, Lainoff AJ, Jamniczky HA, Maltepe E, Hallgrimsson B, Marcucio RS. PMID: 23592613.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    68. Disruption of thrombospondin-2 accelerates ischemic fracture healing. J Orthop Res. 2013 Jun; 31(6):935-43. Miedel E, Dishowitz MI, Myers MH, Dopkin D, Yu YY, Miclau TS, Marcucio R, Ahn J, Hankenson KD. PMID: 23280580.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    69. Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 01; 374(1):185-97. Griffin JN, Compagnucci C, Hu D, Fish J, Klein O, Marcucio R, Depew MJ. PMID: 23201021.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    70. The role of oxygen during fracture healing. Bone. 2013 Jan; 52(1):220-9. Lu C, Saless N, Wang X, Sinha A, Decker S, Kazakia G, Hou H, Williams B, Swartz HM, Hunt TK, Miclau T, Marcucio RS. PMID: 23063782.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    71. MMP9 regulates the cellular response to inflammation after skeletal injury. Bone. 2013 Jan; 52(1):111-9. Wang X, Yu YY, Lieu S, Yang F, Lang J, Lu C, Werb Z, Hu D, Miclau T, Marcucio R, Colnot C. PMID: 23010105.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    72. The generation of variation and the developmental basis for evolutionary novelty. J Exp Zool B Mol Dev Evol. 2012 Sep; 318(6):501-17. Hallgrímsson B, Jamniczky HA, Young NM, Rolian C, Schmidt-Ott U, Marcucio RS. PMID: 22649039.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    73. Anti-inflammatory treatment increases angiogenesis during early fracture healing. Arch Orthop Trauma Surg. 2012 Aug; 132(8):1205-13. Lu C, Xing Z, Wang X, Mao J, Marcucio RS, Miclau T. PMID: 22622792.
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    74. Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects. J Vis Exp. 2012 Apr 11; (62). Yu YY, Bahney C, Hu D, Marcucio RS, Miclau T. PMID: 22525683.
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    75. Neural crest cells pattern the surface cephalic ectoderm during FEZ formation. Dev Dyn. 2012 Apr; 241(4):732-40. Hu D, Marcucio RS. PMID: 22411554.
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    76. The metabolic basis of adolescent idiopathic scoliosis: 2011 report of the "metabolic" workgroup of the Fondation Yves Cotrel. Eur Spine J. 2012 Jun; 21(6):1033-42. Acaroglu E, Bobe R, Enouf J, Marcucio R, Moldovan F, Moreau A. PMID: 22402844.
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    77. Signaling by SHH rescues facial defects following blockade in the brain. Dev Dyn. 2012 Feb; 241(2):247-56. Chong HJ, Young NM, Hu D, Jeong J, McMahon AP, Hallgrimsson B, Marcucio RS. PMID: 22275045.
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    78. Vascular endothelial growth factor improves bone repair in a murine nonunion model. Iowa Orthop J. 2012; 32:90-4. Ogilvie CM, Lu C, Marcucio R, Lee M, Thompson Z, Hu D, Helms JA, Miclau T. PMID: 23576927.
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    79. Epigenetic integration of the developing brain and face. Developmental Dynamics. 2011 Dec 1; 240(12):2697-2697. Trish E. Parsons, Eric J. Schmidt, Julia C. Boughner, Heather A. Jamniczky, Ralph S. Marcucio, Benedikt Hallgrímsson. .
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    80. Is decreased bone mineral density associated with development of scoliosis? A bipedal osteopenic rat model. Scoliosis. 2011 Oct 31; 6(1):24. Dede O, Akel I, Demirkiran G, Yalcin N, Marcucio R, Acaroglu E. PMID: 22040734.
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    82. Mechanical stability affects angiogenesis during early fracture healing. J Orthop Trauma. 2011 Aug; 25(8):494-9. Lu C, Saless N, Hu D, Wang X, Xing Z, Hou H, Williams B, Swartz HM, Colnot C, Miclau T, Marcucio RS. PMID: 21738063.
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    83. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage. 2011 Oct; 19(10):1210-8. Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T. PMID: 21816228.
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    84. Assessing signaling properties of ectodermal epithelia during craniofacial development. J Vis Exp. 2011 Mar 24; (49). Hu D, Marcucio RS. PMID: 21490566.
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    85. Mechanisms that underlie co-variation of the brain and face. Genesis. 2011 Apr; 49(4):177-89. Marcucio RS, Young NM, Hu D, Hallgrimsson B. PMID: 21381182.
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    86. Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2. Dis Model Mech. 2011 Mar; 4(2):203-11. Lieu S, Hansen E, Dedini R, Behonick D, Werb Z, Miclau T, Marcucio R, Colnot C. PMID: 21135056.
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    87. Quantitative analyses link modulation of sonic hedgehog signaling to continuous variation in facial growth and shape. Development. 2010 Oct; 137(20):3405-9. Young NM, Chong HJ, Hu D, Hallgrímsson B, Marcucio RS. PMID: 20826528.
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    88. Trauma-induced inflammation and fracture healing. J Orthop Trauma. 2010 Sep; 24(9):522-5. Pape HC, Marcucio R, Humphrey C, Colnot C, Knobe M, Harvey EJ. PMID: 20736786.
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    89. Rejuvenation of the inflammatory system stimulates fracture repair in aged mice. J Orthop Res. 2010 Aug; 28(8):1000-6. Xing Z, Lu C, Hu D, Miclau T, Marcucio RS. PMID: 20108320.
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    90. Action of IL-1beta during fracture healing. J Orthop Res. 2010 Jun; 28(6):778-84. Lange J, Sapozhnikova A, Lu C, Hu D, Li X, Miclau T, Marcucio RS. PMID: 20041490.
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    91. Recombinant human bone morphogenetic protein-7 enhances fracture healing in an ischemic environment. J Orthop Res. 2010 May; 28(5):687-96. Lu C, Xing Z, Yu YY, Colnot C, Miclau T, Marcucio RS. PMID: 19918910.
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    92. Multiple roles for CCR2 during fracture healing. Dis Model Mech. 2010 Jul-Aug; 3(7-8):451-8. Xing Z, Lu C, Hu D, Yu YY, Wang X, Colnot C, Nakamura M, Wu Y, Miclau T, Marcucio RS. PMID: 20354109.
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    93. Absence of beta3 integrin accelerates early skeletal repair. J Orthop Res. 2010 Jan; 28(1):32-7. Hu D, Lu C, Sapozhnikova A, Barnett M, Sparrey C, Miclau T, Marcucio RS. PMID: 19637214.
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    94. Deciphering the Palimpsest: Studying the Relationship Between Morphological Integration and Phenotypic Covariation. Evol Biol. 2009 Dec; 36(4):355-376. Hallgrímsson B, Jamniczky H, Young NM, Rolian C, Parsons TE, Boughner JC, Marcucio RS. PMID: 23293400.
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    96. Basic research in orthopedic surgery: Current trends and future directions. Indian J Orthop. 2009 Oct; 43(4):318-23. Lu C, Buckley JM, Colnot C, Marcucio R, Miclau T. PMID: 19838378.
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    97. Comparison of the melatonin and calmodulin in paravertebral muscle and platelets of patients with or without adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2009 Aug 15; 34(18):E659-63. Acaroglu E, Akel I, Alanay A, Yazici M, Marcucio R. PMID: 19680092.
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    98. The effect of calmodulin antagonists on experimental scoliosis: a pinealectomized chicken model. Spine (Phila Pa 1976). 2009 Mar 15; 34(6):533-8. Akel I, Kocak O, Bozkurt G, Alanay A, Marcucio R, Acaroglu E. PMID: 19282733.
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    99. The effect of calmodulin antagonists on scoliosis: bipedal C57BL/6 mice model. Eur Spine J. 2009 Apr; 18(4):499-505. Akel I, Demirkiran G, Alanay A, Karahan S, Marcucio R, Acaroglu E. PMID: 19242737.
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    100. Effect of bone morphogenetic protein signaling on development of the jaw skeleton. Dev Dyn. 2008 Dec; 237(12):3727-37. Hu D, Colnot C, Marcucio RS. PMID: 18985754.
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    101. A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm. Development. 2009 Jan; 136(1):107-16. Hu D, Marcucio RS. PMID: 19036802.
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    102. Unique organization of the frontonasal ectodermal zone in birds and mammals. Dev Biol. 2009 Jan 01; 325(1):200-10. Hu D, Marcucio RS. PMID: 19013147.
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    103. Effect of age on vascularization during fracture repair. J Orthop Res. 2008 Oct; 26(10):1384-9. Lu C, Hansen E, Sapozhnikova A, Hu D, Miclau T, Marcucio RS. PMID: 18464248.
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    104. Tibial fracture decreases oxygen levels at the site of injury. Iowa Orthop J. 2008; 28:14-21. Lu C, Rollins M, Hou H, Swartz HM, Hopf H, Miclau T, Marcucio RS. PMID: 19223943.
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    105. Effects of delayed stabilization on fracture healing. J Orthop Res. 2007 Dec; 25(12):1552-8. Miclau T, Lu C, Thompson Z, Choi P, Puttlitz C, Marcucio R, Helms JA. PMID: 17593540.
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    106. Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. PLoS One. 2007 Nov 07; 2(11):e1150. Behonick DJ, Xing Z, Lieu S, Buckley JM, Lotz JC, Marcucio RS, Werb Z, Miclau T, Colnot C. PMID: 17987127.
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    107. Signaling by bone morphogenetic proteins directs formation of an ectodermal signaling center that regulates craniofacial development. Dev Biol. 2007 Dec 01; 312(1):103-14. Foppiano S, Hu D, Marcucio RS. PMID: 18028903.
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    108. Bone morphogenetic proteins (BMPs) direct formation of a signaling center that regulates facial development. Developmental Biology. 2007 Jun 1; 306(1):401-402. Ralph S. Marcucio, Silvia Foppiano, Diane Hu. .
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    109. Ischemia leads to delayed union during fracture healing: a mouse model. J Orthop Res. 2007 Jan; 25(1):51-61. Lu C, Miclau T, Hu D, Marcucio RS. PMID: 17019699.
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    110. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development. Pediatrics. 2006 Mar; 117(3):698-703. Haggstrom AN, Lammer EJ, Schneider RA, Marcucio R, Frieden IJ. PMID: 16510649.
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    111. Assessing angiogenesis during fracture healing. Iowa Orthop J. 2006; 26:17-26. Lu C, Marcucio R, Miclau T. PMID: 16789443.
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    112. Cellular basis for age-related changes in fracture repair. Journal of Orthopaedic Research®. 2005 Nov 1; 23(6):1300-1307. C LU, T MICLAU, D HU, E HANSEN, K TSUI, C PUTTLITZ, R MARCUCIO. .
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    113. Molecular interactions coordinating the development of the forebrain and face. Dev Biol. 2005 Aug 01; 284(1):48-61. Marcucio RS, Cordero DR, Hu D, Helms JA. PMID: 15979605.
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    114. Cellular basis for age-related changes in fracture repair. J Orthop Res. 2005 Nov; 23(6):1300-7. Lu C, Miclau T, Hu D, Hansen E, Tsui K, Puttlitz C, Marcucio RS. PMID: 15936915.
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    115. The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet. 2004 Nov; 36(11):1133-7. Churchill GA, Airey DC, Allayee H, Angel JM, Attie AD, Beatty J, Beavis WD, Belknap JK, Bennett B, Berrettini W, Bleich A, Bogue M, Broman KW, Buck KJ, Buckler E, Burmeister M, Chesler EJ, Cheverud JM, Clapcote S, Cook MN, Cox RD, Crabbe JC, Crusio WE, Darvasi A, Deschepper CF, Doerge RW, Farber CR, Forejt J, Gaile D, Garlow SJ, Geiger H, Gershenfeld H, Gordon T, Gu J, Gu W, de Haan G, Hayes NL, Heller C, Himmelbauer H, Hitzemann R, Hunter K, Hsu HC, Iraqi FA, Ivandic B, Jacob HJ, Jansen RC, Jepsen KJ, Johnson DK, Johnson TE, Kempermann G, Kendziorski C, Kotb M, Kooy RF, Llamas B, Lammert F, Lassalle JM, Lowenstein PR, Lu L, Lusis A, Manly KF, Marcucio R, Matthews D, Medrano JF, Miller DR, Mittleman G, Mock BA, Mogil JS, Montagutelli X, Morahan G, Morris DG, Mott R, Nadeau JH, Nagase H, Nowakowski RS, O'Hara BF, Osadchuk AV, Page GP, Paigen B, Paigen K, Palmer AA, Pan HJ, Peltonen-Palotie L, Peirce J, Pomp D, Pravenec M, Prows DR, Qi Z, Reeves RH, Roder J, Rosen GD, Schadt EE, Schalkwyk LC, Seltzer Z, Shimomura K, Shou S, Sillanpää MJ, Siracusa LD, Snoeck HW, Spearow JL, Svenson K, Tarantino LM, Threadgill D, Toth LA, Valdar W, de Villena FP, Warden C, Whatley S, Williams RW, Wiltshire T, Yi N, Zhang D, Zhang M, Zou F. PMID: 15514660.
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    116. Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. J Clin Invest. 2004 Aug; 114(4):485-94. Cordero D, Marcucio R, Hu D, Gaffield W, Tapadia M, Helms JA. PMID: 15314685.
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    117. Morphogenesis of blood vessels in the head muscles of avian embryo: spatial, temporal, and VEGF expression analyses. Dev Dyn. 2003 Aug; 227(4):470-83. Ruberte J, Carretero A, Navarro M, Marcucio RS, Noden D. PMID: 12889056.
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    118. A zone of frontonasal ectoderm regulates patterning and growth in the face. Development. 2003 May; 130(9):1749-58. Hu D, Marcucio RS, Helms JA. PMID: 12642481.
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    119. Prenatal morphogenesis of the human mental foramen. Eur J Oral Sci. 2002 Dec; 110(6):452-9. Radlanski RJ, Renz H, Müller U, Schneider RS, Marcucio RS, Helms JA. PMID: 12507219.
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    120. Differentiation of avian craniofacial muscles: I. Patterns of early regulatory gene expression and myosin heavy chain synthesis. Dev Dyn. 1999 Oct; 216(2):96-112. Noden DM, Marcucio R, Borycki AG, Emerson CP. PMID: 10536051.
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    121. Myotube heterogeneity in developing chick craniofacial skeletal muscles. Dev Dyn. 1999 Mar; 214(3):178-94. Marcucio RS, Noden DM. PMID: 10090145.
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    122. In vitro interaction between oviduct epithelial and equine sperm. Arch Androl. 1993 Sep-Oct; 31(2):79-86. Ellington JE, Ignotz GG, Varner DD, Marcucio RS, Mathison P, Ball BA. PMID: 8215695.
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