Balyn Zaro, PhD

Title(s)Associate Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
AddressSan Francisco CA 94158
Phone415-514-9219
ORCID ORCID Icon0000-0002-8938-9889 Additional info
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    Collapse Biography 
    Collapse education and training
    Stanford School of Medicine, Stanford, CA08/2019Stem Cell Biology and Innate Immunity
    Scripps Research Institute, La Jolla, CA08/2017Chemical Biology
    University of Southern California, Los Angeles, CAPh.D.08/2014Chemical Biology
    University of Southern California, Los Angeles, CAB.S.06/2009Chemistry

    Collapse Overview 

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Macrophages release neuraminidase and cleaved calreticulin for programmed cell removal. Proc Natl Acad Sci U S A. 2025 May 27; 122(21):e2426644122. Banuelos A, Baez M, Zhang A, Yilmaz L, Kasberg W, Volk R, Georgeos N, Koren-Sedova E, Le U, Burden AT, Marjon KD, Lippincott-Schwartz J, Zaro BW, Weissman IL. PMID: 40397678.
      View in: PubMed   Mentions:    Fields:    
    2. Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein. Nat Biotechnol. 2025 Apr 23. George BM, Eleftheriou M, Yankova E, Perr J, Chai P, Nestola G, Almahayni K, Evans S, Damaskou A, Hemberger H, Lebedenko CG, Rak J, Yu Q, Bapcum E, Russell J, Bagri J, Volk RF, Spiekermann M, Stone RM, Giotopoulos G, Huntly BJP, Baxter J, Camargo F, Liu J, Zaro BW, Vassiliou GS, Möckl L, de la Rosa J, Flynn RA, Tzelepis K. PMID: 40269321.
      View in: PubMed   Mentions:    Fields:    
    3. RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry. Cell. 2025 Apr 03; 188(7):1878-1895.e25. Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA. PMID: 40020667; PMCID: PMC11972160.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    4. C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin. bioRxiv. 2025 Jan 20. Mella J, Volk R, Zaro B, Buchwalter A. PMID: 39896633; PMCID: PMC11785080.
      View in: PubMed   Mentions:
    5. Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology. bioRxiv. 2024 Oct 29. Boucher MJ, Banerjee S, Joshi MB, Wei AL, Huang MY, Lei S, Ciranni M, Condon A, Langen A, Goddard TD, Caradonna I, Goranov AI, Homer CM, Mortensen Y, Petnic S, Reilly MC, Xiong Y, Susa KJ, Pastore VP, Zaro BW, Madhani HD. PMID: 39484549; PMCID: PMC11526942.
      View in: PubMed   Mentions:
    6. O-GlcNAc modification of HSP27 alters its protein interactions and promotes refolding of proteins through the BAG3/HSP70 co-chaperone. Protein Sci. 2024 Oct; 33(10):e5173. Javed A, Johnson OT, Balana AT, Volk RF, Langen A, Ahn BS, Zaro BW, Gestwicki JE, Pratt MR. PMID: 39291732; PMCID: PMC11409196.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi. bioRxiv. 2024 Apr 30. Tal MC, Hansen PS, Ogasawara HA, Feng Q, Volk RF, Lee B, Casebeer SE, Blacker GS, Shoham M, Galloway SD, Sapiro AL, Hayes B, Torrez Dulgeroff LB, Raveh T, Pothineni VR, Potula HS, Rajadas J, Bastounis EE, Chou S, Robinson WH, Coburn J, Weissman IL, Zaro BW. PMID: 38746193; PMCID: PMC11092639.
      View in: PubMed   Mentions:
    8. Correction to "Changes in Metabolic Chemical Reporter Structure Yield a Selective Probe of O-GlcNAc Modification". J Am Chem Soc. 2023 Oct 11; 145(40):22284. Chuh KN, Zaro BW, Piller F, Piller V, Pratt MR. PMID: 37774147; PMCID: PMC10571073.
      View in: PubMed   Mentions:    Fields:    
    9. Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission. Elife. 2023 Jul 14; 12. Sapiro AL, Hayes BM, Volk RF, Zhang JY, Brooks DM, Martyn C, Radkov A, Zhao Z, Kinnersley M, Secor PR, Zaro BW, Chou S. PMID: 37449477; PMCID: PMC10393048.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    10. EMC chaperone-CaV structure reveals an ion channel assembly intermediate. Nature. 2023 Jul; 619(7969):410-419. Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL. PMID: 37196677; PMCID: PMC10896479.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    11. MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes. Cell Rep. 2023 03 28; 42(3):112249. Datta R, Gholampour MA, Yang CD, Volk R, Lin S, Podolsky MJ, Arnold T, Rieder F, Zaro BW, Verzi M, Lehner R, Abumrad N, Lizama CO, Atabai K. PMID: 36924494; PMCID: PMC10138282.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions. PLoS Biol. 2022 08; 20(8):e3001759. Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Volk RF, Hofmann KL, Zaro B, Chuang PT. PMID: 36026468; PMCID: PMC9469998.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Secreted fungal virulence effector triggers allergic inflammation via TLR4. Nature. 2022 08; 608(7921):161-167. Dang EV, Lei S, Radkov A, Volk RF, Zaro BW, Madhani HD. PMID: 35896747; PMCID: PMC9744105.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    14. Improved Electrophile Design for Exquisite Covalent Molecule Selectivity. ACS Chem Biol. 2022 06 17; 17(6):1440-1449. Montaño JL, Wang BJ, Volk RF, Warrington SE, Garda VG, Hofmann KL, Chen LC, Zaro BW. PMID: 35587148.
      View in: PubMed   Mentions: 3     Fields:    
    15. Proteomic characterization of phagocytic primary human monocyte-derived macrophages. RSC Chem Biol. 2022 Jun 08; 3(6):783-793. Volk RF, Montaño JL, Warrington SE, Hofmann KL, Zaro BW. PMID: 35755185; PMCID: PMC9175098.
      View in: PubMed   Mentions:
    16. Refinement of Covalent EGFR Inhibitor AZD9291 to Eliminate Off-target Activity. Tetrahedron Lett. 2021 Jun 22; 74. Bouffard E, Zaro BW, Dix MM, Cravatt B, Wong CH. PMID: 34764521; PMCID: PMC8577418.
      View in: PubMed   Mentions: 3     Fields:    
    17. Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells. Elife. 2020 11 25; 9. Zaro BW, Noh JJ, Mascetti VL, Demeter J, George B, Zukowska M, Gulati GS, Sinha R, Flynn RA, Banuelos A, Zhang A, Wilkinson AC, Jackson P, Weissman IL. PMID: 33236985; PMCID: PMC7688314.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    18. Metabolic Labeling for the Visualization and Identification of Potentially O-GlcNAc-Modified Proteins. Curr Protoc Chem Biol. 2020 06; 12(2):e81. Pedowitz NJ, Zaro BW, Pratt MR. PMID: 32289208; PMCID: PMC7502289.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    19. O-Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent Background Labeling of Proteins but Are Generally Reliable Tools for the Identification of Glycoproteins. Front Chem. 2020; 8:318. Darabedian N, Yang B, Ding R, Cutolo G, Zaro BW, Woo CM, Pratt MR. PMID: 32411667; PMCID: PMC7198827.
      View in: PubMed   Mentions: 9  
    20. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature. 2019 08; 572(7769):392-396. Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, Krishnan V, Hatakeyama J, Dorigo O, Barkal LJ, Weissman IL. PMID: 31367043; PMCID: PMC6697206.
      View in: PubMed   Mentions: 570     Fields:    Translation:HumansCells
    21. The Proteome-Wide Potential for Reversible Covalency at Cysteine. Angew Chem Int Ed Engl. 2019 08 12; 58(33):11385-11389. Senkane K, Vinogradova EV, Suciu RM, Crowley VM, Zaro BW, Bradshaw JM, Brameld KA, Cravatt BF. PMID: 31222866; PMCID: PMC6684851.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    22. Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4-MyD88 Complex. J Immunol. 2019 05 01; 202(9):2737-2746. Zaro BW, Vinogradova EV, Lazar DC, Blewett MM, Suciu RM, Takaya J, Studer S, de la Torre JC, Casanova JL, Cravatt BF, Teijaro JR. PMID: 30885957; PMCID: PMC6478521.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    23. Azide- and Alkyne-Bearing Metabolic Chemical Reporters of Glycosylation Show Structure-Dependent Feedback Inhibition of the Hexosamine Biosynthetic Pathway. Chembiochem. 2018 09 17; 19(18):1918-1921. Walter LA, Batt AR, Darabedian N, Zaro BW, Pratt MR. PMID: 29979493; PMCID: PMC6261355.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    24. Correction to "An Alkyne-Aspirin Chemical Reporter for the Detection of Aspirin-Dependent Protein Modification in Living Cells". J Am Chem Soc. 2018 04 11; 140(14):4954. Bateman LA, Zaro BW, Miller SM, Pratt MR. PMID: 29589917.
      View in: PubMed   Mentions:    Fields:    
    25. The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8. J Am Chem Soc. 2017 06 14; 139(23):7872-7885. Chuh KN, Batt AR, Zaro BW, Darabedian N, Marotta NP, Brennan CK, Amirhekmat A, Pratt MR. PMID: 28528544; PMCID: PMC6225779.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    26. Metabolic Chemical Reporters of Glycans Exhibit Cell-Type-Selective Metabolism and Glycoprotein Labeling. Chembiochem. 2017 07 04; 18(13):1177-1182. Batt AR, Zaro BW, Navarro MX, Pratt MR. PMID: 28231413; PMCID: PMC5580397.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    27. The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase. ACS Chem Biol. 2017 03 17; 12(3):787-794. Zaro BW, Batt AR, Chuh KN, Navarro MX, Pratt MR. PMID: 28135057; PMCID: PMC6223259.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    28. Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible Inhibitors. J Am Chem Soc. 2016 12 14; 138(49):15841-15844. Zaro BW, Whitby LR, Lum KM, Cravatt BF. PMID: 27960302; PMCID: PMC5273863.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    29. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells. Sci Signal. 2016 09 13; 9(445):rs10. Blewett MM, Xie J, Zaro BW, Backus KM, Altman A, Teijaro JR, Cravatt BF. PMID: 27625306; PMCID: PMC5068918.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    30. O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. Nat Chem. 2015 Nov; 7(11):913-20. Marotta NP, Lin YH, Lewis YE, Ambroso MR, Zaro BW, Roth MT, Arnold DB, Langen R, Pratt MR. PMID: 26492012; PMCID: PMC4618406.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansCells
    31. Chemoproteomics reveals Toll-like receptor fatty acylation. BMC Biol. 2014 Nov 05; 12:91. Chesarino NM, Hach JC, Chen JL, Zaro BW, Rajaram MV, Turner J, Schlesinger LS, Pratt MR, Hang HC, Yount JS. PMID: 25371237; PMCID: PMC4240870.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    32. Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification. J Am Chem Soc. 2014 Sep 03; 136(35):12283-95. Chuh KN, Zaro BW, Piller F, Piller V, Pratt MR. PMID: 25153642; PMCID: PMC4156869.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    33. Chemical reporter for visualizing metabolic cross-talk between carbohydrate metabolism and protein modification. ACS Chem Biol. 2014 Sep 19; 9(9):1991-6. Zaro BW, Chuh KN, Pratt MR. PMID: 25062036; PMCID: PMC4168799.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    34. Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy. PLoS One. 2014; 9(5):e95561. Gurel Z, Zaro BW, Pratt MR, Sheibani N. PMID: 24788674; PMCID: PMC4006792.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    35. An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells. J Am Chem Soc. 2013 Oct 02; 135(39):14568-73. Bateman LA, Zaro BW, Miller SM, Pratt MR. PMID: 23998633.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    36. Incorporation of unnatural sugars for the identification of glycoproteins. Methods Mol Biol. 2013; 951:57-67. Zaro BW, Hang HC, Pratt MR. PMID: 23296524; PMCID: PMC4228939.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    37. N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation. Chem Commun (Camb). 2013 May 14; 49(39):4328-30. Bateman LA, Zaro BW, Chuh KN, Pratt MR. PMID: 23235740; PMCID: PMC6223258.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    38. Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8146-51. Zaro BW, Yang YY, Hang HC, Pratt MR. PMID: 21540332; PMCID: PMC3100932.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    39. Robust in-gel fluorescence detection of mucin-type O-linked glycosylation. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):5062-6. Zaro BW, Bateman LA, Pratt MR. PMID: 21531554.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    40. Precise control of protein concentration in living cells. Angew Chem Int Ed Engl. 2010 Nov 02; 49(45):8458-61. Lau HD, Yaegashi J, Zaro BW, Pratt MR. PMID: 20878685.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
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