Anil Bhushan, PhD
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Title(s) | Professor, Diabetes Center |
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School | School of Medicine |
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Address | 513 Parnassus Ave, HSW San Francisco CA 94143
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Phone | 415-502-3295 |
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vCard | Download vCard |
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Biography Salk Institute, La Jolla, CA | Postdoctoral | 1999 | Development Biology | UCDavis, Davis CA | PhD | 1992 | Biochemistry and Biophysics | INSERM, Paris, France | | 2001 | Diabetes |
Overview The long-term goal of my research is to understand the role of tissue secretory senescent cells in aging, autoimmunity and metabolic diseases. Our recent discovery shows that pancreatic beta cells acquire a secretome during T1D in mice and human and exhibit many non-cell autonomous properties. Senescent beta cells can remodel the islet environment in a paracrine manner by promoting bystander senescence and immune surveillance. We have identified key immune cells that can selectively eliminated senescent beta cells to halted progression of beta cell destruction prevent T1D in mouse models. We use a combination of mouse models of autoimmunity, humanized mouse models transplanted with senescent cells to investigate the underlying mechanism by which tissue senescent cells contribute to the development of the various diseases. We also now use utilize immune modulatory targets to identify new drugs that specifically eliminate tissue senescent human cells and develop an in vivo humanized mouse model to test efficacy of drugs to clear human senescent cells.
Research ORNG Applications Bibliographic
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BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes. Int J Mol Sci. 2019 Sep 26; 20(19).
Thompson PJ, Shah A, Apostolopolou H, Bhushan A. PMID: 31561444.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
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mTORC1 to AMPK switching underlies ß-cell metabolic plasticity during maturation and diabetes. J Clin Invest. 2019 07 02; 129(10):4124-4137.
Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A. PMID: 31265435.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet ß-Cell Function. Diabetes. 2019 09; 68(9):1806-1818.
Spaeth JM, Liu JH, Peters D, Guo M, Osipovich AB, Mohammadi F, Roy N, Bhushan A, Magnuson MA, Hebrok M, Wright CVE, Stein R. PMID: 31201281.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Author Correction: Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived ß cells. Nat Cell Biol. 2019 06; 21(6):792.
Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M. PMID: 30914825.
View in: PubMed Mentions: Fields:
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Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes. Cell Metab. 2019 05 07; 29(5):1045-1060.e10.
Thompson PJ, Shah A, Ntranos V, Van Gool F, Atkinson M, Bhushan A. PMID: 30799288.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimalsCells
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Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived ß cells. Nat Cell Biol. 2019 02; 21(2):263-274.
Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M. PMID: 30710150.
View in: PubMed Mentions: 31 Fields: Translation: HumansAnimalsCells
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Examining How the MAFB Transcription Factor Affects Islet ß-Cell Function Postnatally. Diabetes. 2019 02; 68(2):337-348.
Cyphert HA, Walker EM, Hang Y, Dhawan S, Haliyur R, Bonatakis L, Avrahami D, Brissova M, Kaestner KH, Bhushan A, Powers AC, Stein R. PMID: 30425060.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimalsCells
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Cyclin D2 is sufficient to drive ß cell self-renewal and regeneration. Cell Cycle. 2017; 16(22):2183-2191.
Tschen SI, Zeng C, Field L, Dhawan S, Bhushan A, Georgia S. PMID: 28763258.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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ß Cells led astray by transcription factors and the company they keep. J Clin Invest. 2017 01 03; 127(1):94-97.
Thompson P, Bhushan A. PMID: 27941244.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
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Inhibition of TGF-ß Signaling Promotes Human Pancreatic ß-Cell Replication. Diabetes. 2016 05; 65(5):1208-18.
Dhawan S, Dirice E, Kulkarni RN, Bhushan A. PMID: 26936960.
View in: PubMed Mentions: 20 Fields: Translation: HumansAnimalsCells
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DNA methylation directs functional maturation of pancreatic ß cells. J Clin Invest. 2015 Jul 01; 125(7):2851-60.
Dhawan S, Tschen SI, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A. PMID: 26098213.
View in: PubMed Mentions: 44 Fields: Translation: HumansAnimalsCells
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Human ß-cell proliferation and intracellular signaling: part 3. Diabetes. 2015 Jun; 64(6):1872-85.
Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN. PMID: 25999530.
View in: PubMed Mentions: 43 Fields: Translation: HumansAnimalsCells
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Combined modulation of polycomb and trithorax genes rejuvenates ß cell replication. J Clin Invest. 2013 Nov; 123(11):4849-58.
Zhou JX, Dhawan S, Fu H, Snyder E, Bottino R, Kundu S, Kim SK, Bhushan A. PMID: 24216481.
View in: PubMed Mentions: 28 Fields: Translation: HumansAnimalsCells
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The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation. EMBO J. 2013 May 15; 32(10):1393-408.
Kartikasari AE, Zhou JX, Kanji MS, Chan DN, Sinha A, Grapin-Botton A, Magnuson MA, Lowry WE, Bhushan A. PMID: 23584530.
View in: PubMed Mentions: 38 Fields: Translation: HumansAnimalsCells
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DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis. Genes Dev. 2013 Feb 15; 27(4):372-7.
Georgia S, Kanji M, Bhushan A. PMID: 23431054.
View in: PubMed Mentions: 25 Fields: Translation: AnimalsCells
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Dicer1 is required to repress neuronal fate during endocrine cell maturation. Diabetes. 2013 May; 62(5):1602-11.
Kanji MS, Martin MG, Bhushan A. PMID: 23382448.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Nkx2.2 repressor complex regulates islet ß-cell specification and prevents ß-to-a-cell reprogramming. Genes Dev. 2011 Nov 01; 25(21):2291-305.
Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L. PMID: 22056672.
View in: PubMed Mentions: 75 Fields: Translation: AnimalsCells
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Skp2 is required for incretin hormone-mediated ß-cell proliferation. Mol Endocrinol. 2011 Dec; 25(12):2134-43.
Tschen SI, Georgia S, Dhawan S, Bhushan A. PMID: 21980072.
View in: PubMed Mentions: 15 Fields: Translation: HumansAnimalsCells
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Pancreatic ß cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell. 2011 Apr 19; 20(4):419-29.
Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A. PMID: 21497756.
View in: PubMed Mentions: 98 Fields: Translation: AnimalsCells
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Pregnancy hormones boost beta cells via serotonin. Nat Med. 2010 Jul; 16(7):756-7.
Georgia S, Bhushan A. PMID: 20613752.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
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Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E713-20.
Matveyenko AV, Georgia S, Bhushan A, Butler PC. PMID: 20587750.
View in: PubMed Mentions: 22 Fields: Translation: HumansAnimalsCells
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Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes. 2010 Apr; 59(4):987-96.
Georgia S, Hinault C, Kawamori D, Hu J, Meyer J, Kanji M, Bhushan A, Kulkarni RN. PMID: 20103709.
View in: PubMed Mentions: 34 Fields: Translation: AnimalsCells
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Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes Dev. 2009 Apr 15; 23(8):906-11.
Dhawan S, Tschen SI, Bhushan A. PMID: 19390085.
View in: PubMed Mentions: 115 Fields: Translation: AnimalsCells
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Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. Diabetes. 2009 Jun; 58(6):1312-20.
Tschen SI, Dhawan S, Gurlo T, Bhushan A. PMID: 19228811.
View in: PubMed Mentions: 137 Fields: Translation: AnimalsCells
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Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass. PLoS One. 2009; 4(2):e4394.
Schulthess FT, Katz S, Ardestani A, Kawahira H, Georgia S, Bosco D, Bhushan A, Maedler K. PMID: 19197367.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes. 2008 Jun; 57(6):1584-94.
Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A, Rizza RA, Butler PC. PMID: 18334605.
View in: PubMed Mentions: 279 Fields: Translation: HumansCells
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Formation and regeneration of the endocrine pancreas. Curr Opin Cell Biol. 2007 Dec; 19(6):634-45.
Dhawan S, Georgia S, Bhushan A. PMID: 18061427.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimals
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The replication of beta cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab. 2007 Nov; 3(11):758-68.
Butler PC, Meier JJ, Butler AE, Bhushan A. PMID: 17955017.
View in: PubMed Mentions: 109 Fields: Translation: HumansAnimalsCells
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Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. J Clin Invest. 2007 Oct; 117(10):2869-76.
Zhong L, Georgia S, Tschen SI, Nakayama K, Nakayama K, Bhushan A. PMID: 17823659.
View in: PubMed Mentions: 53 Fields: Translation: AnimalsCells
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Hematopoietic stem cells derived from adult donors are not a source of pancreatic beta-cells in adult nondiabetic humans. Diabetes. 2007 Jul; 56(7):1810-6.
Butler AE, Huang A, Rao PN, Bhushan A, Hogan WJ, Rizza RA, Butler PC. PMID: 17456852.
View in: PubMed Mentions: 13 Fields: Translation: HumansCells
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p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes. 2006 Nov; 55(11):2950-6.
Georgia S, Bhushan A. PMID: 17065330.
View in: PubMed Mentions: 50 Fields: Translation: AnimalsCells
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p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol. 2006 Oct 01; 298(1):22-31.
Georgia S, Soliz R, Li M, Zhang P, Bhushan A. PMID: 16899237.
View in: PubMed Mentions: 64 Fields: Translation: AnimalsCells
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The potential for stem cell therapy in diabetes. Pediatr Res. 2006 Apr; 59(4 Pt 2):65R-73R.
Meier JJ, Bhushan A, Butler PC. PMID: 16549551.
View in: PubMed Mentions: 18 Fields: Translation: Humans
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Formation of pancreatic duct epithelium from bone marrow during neonatal development. Stem Cells. 2006 Feb; 24(2):307-14.
Wang X, Ge S, Gonzalez I, McNamara G, Rountree CB, Xi KK, Huang G, Bhushan A, Crooks GM. PMID: 16510429.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest. 2004 Oct; 114(7):963-8.
Georgia S, Bhushan A. PMID: 15467835.
View in: PubMed Mentions: 214 Fields: Translation: Animals
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Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development. 2001 Dec; 128(24):5109-17.
Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R. PMID: 11748146.
View in: PubMed Mentions: 157 Fields: Translation: AnimalsCells
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Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos. Dev Biol. 1998 Aug 15; 200(2):260-8.
Bhushan A, Chen Y, Vale W. PMID: 9705232.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):12938-43.
Chen Y, Bhushan A, Vale W. PMID: 9371779.
View in: PubMed Mentions: 27 Fields: Translation: AnimalsCells
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The transforming growth factor beta type II receptor can replace the activin type II receptor in inducing mesoderm. Mol Cell Biol. 1994 Jun; 14(6):4280-5.
Bhushan A, Lin HY, Lodish HF, Kintner CR. PMID: 8196664.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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Year | Publications |
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1994 | 1 | 1997 | 1 | 1998 | 1 | 2001 | 1 | 2004 | 1 | 2006 | 4 | 2007 | 4 | 2008 | 1 | 2009 | 3 | 2010 | 3 | 2011 | 3 | 2013 | 4 | 2015 | 2 | 2016 | 2 | 2017 | 1 | 2018 | 1 | 2019 | 6 |
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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