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Anil Bhushan, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentDiabetes Center
Address513 Parnassus Avenue
San Francisco CA 94117
Phone415-502-3295
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    Collapse Biography 
    Collapse Education and Training
    UCDavisPhD1992Biochemistry and Biophysics
    Salk InstitutePostdoctoral 1999

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of beta cell maturation
    NIH/NIDDK R01DK108666Sep 30, 2015 - Jul 31, 2019
    Role: Co-Principal Investigator
    Polycomb genes regulation of beta cell regeneration
    NIH/NIDDK R01DK080996Mar 1, 2008 - Apr 30, 2018
    Role: Principal Investigator
    Cell Cycle Control Of Beta Cell Mass
    NIH/NIDDK R01DK068763Jul 5, 2004 - Jun 30, 2016
    Role: Principal Investigator
    SPECIFICITY OF ACTIVIN SIGNALING THROUGH TYPE I RECEPTOR
    NIH/NICHD F32HD007969Sep 9, 1995
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Featured Videos
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tschen SI, Zeng C, Field L, Dhawan S, Bhushan A, Georgia S. Cyclin D2 is sufficient to drive beta cell self-renewal and regeneration. Cell Cycle. 2017 Aug 01; 0. PMID: 28763258.
      View in: PubMed
    2. Thompson P, Bhushan A. ß Cells led astray by transcription factors and the company they keep. J Clin Invest. 2017 Jan 03; 127(1):94-97. PMID: 27941244.
      View in: PubMed
    3. Dhawan S, Dirice E, Kulkarni RN, Bhushan A. Inhibition of TGF-ß Signaling Promotes Human Pancreatic ß-Cell Replication. Diabetes. 2016 May; 65(5):1208-18. PMID: 26936960; PMCID: PMC4839200 [Available on 05/01/17].
      View in: PubMed, PubMed Central
    4. Dhawan S, Tschen SI, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A. DNA methylation directs functional maturation of pancreatic ß cells. J Clin Invest. 2015 Jul 01; 125(7):2851-60. PMID: 26098213; PMCID: PMC4563682.
      View in: PubMed, PubMed Central
    5. Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN. Human ß-cell proliferation and intracellular signaling: part 3. Diabetes. 2015 Jun; 64(6):1872-85. PMID: 25999530; PMCID: PMC4439562.
      View in: PubMed, PubMed Central
    6. Zhou JX, Dhawan S, Fu H, Snyder E, Bottino R, Kundu S, Kim SK, Bhushan A. Combined modulation of polycomb and trithorax genes rejuvenates ß cell replication. J Clin Invest. 2013 Nov; 123(11):4849-58. PMID: 24216481; PMCID: PMC3809789.
      View in: PubMed, PubMed Central
    7. Kartikasari AE, Zhou JX, Kanji MS, Chan DN, Sinha A, Grapin-Botton A, Magnuson MA, Lowry WE, Bhushan A. The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and Eomes to drive endoderm differentiation. EMBO J. 2013 May 15; 32(10):1393-408. PMID: 23584530; PMCID: PMC3655467.
      View in: PubMed, PubMed Central
    8. Georgia S, Kanji M, Bhushan A. DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis. Genes Dev. 2013 Feb 15; 27(4):372-7. PMID: 23431054; PMCID: PMC3589554.
      View in: PubMed, PubMed Central
    9. Kanji MS, Martin MG, Bhushan A. Dicer1 is required to repress neuronal fate during endocrine cell maturation. Diabetes. 2013 May; 62(5):1602-11. PMID: 23382448; PMCID: PMC3636616.
      View in: PubMed, PubMed Central
    10. Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L. Nkx2.2 repressor complex regulates islet ß-cell specification and prevents ß-to-a-cell reprogramming. Genes Dev. 2011 Nov 01; 25(21):2291-305. PMID: 22056672; PMCID: PMC3219233.
      View in: PubMed, PubMed Central
    11. Tschen SI, Georgia S, Dhawan S, Bhushan A. Skp2 is required for incretin hormone-mediated ß-cell proliferation. Mol Endocrinol. 2011 Dec; 25(12):2134-43. PMID: 21980072; PMCID: PMC3231831.
      View in: PubMed, PubMed Central
    12. Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A. Pancreatic ß cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell. 2011 Apr 19; 20(4):419-29. PMID: 21497756; PMCID: PMC3086024.
      View in: PubMed, PubMed Central
    13. Georgia S, Bhushan A. Pregnancy hormones boost beta cells via serotonin. Nat Med. 2010 Jul; 16(7):756-7. PMID: 20613752.
      View in: PubMed
    14. Matveyenko AV, Georgia S, Bhushan A, Butler PC. Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats. Am J Physiol Endocrinol Metab. 2010 Nov; 299(5):E713-20. PMID: 20587750; PMCID: PMC3774125.
      View in: PubMed, PubMed Central
    15. Georgia S, Hinault C, Kawamori D, Hu J, Meyer J, Kanji M, Bhushan A, Kulkarni RN. Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes. 2010 Apr; 59(4):987-96. PMID: 20103709; PMCID: PMC2844846.
      View in: PubMed, PubMed Central
    16. Dhawan S, Tschen SI, Bhushan A. Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes Dev. 2009 Apr 15; 23(8):906-11. PMID: 19390085; PMCID: PMC2675870.
      View in: PubMed, PubMed Central
    17. Tschen SI, Dhawan S, Gurlo T, Bhushan A. Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. Diabetes. 2009 Jun; 58(6):1312-20. PMID: 19228811; PMCID: PMC2682690.
      View in: PubMed, PubMed Central
    18. Schulthess FT, Katz S, Ardestani A, Kawahira H, Georgia S, Bosco D, Bhushan A, Maedler K. Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass. PLoS One. 2009; 4(2):e4394. PMID: 19197367; PMCID: PMC2632884.
      View in: PubMed, PubMed Central
    19. Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A, Rizza RA, Butler PC. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes. 2008 Jun; 57(6):1584-94. PMID: 18334605; PMCID: PMC3697779.
      View in: PubMed, PubMed Central
    20. Dhawan S, Georgia S, Bhushan A. Formation and regeneration of the endocrine pancreas. Curr Opin Cell Biol. 2007 Dec; 19(6):634-45. PMID: 18061427; PMCID: PMC2695413.
      View in: PubMed, PubMed Central
    21. Butler PC, Meier JJ, Butler AE, Bhushan A. The replication of beta cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab. 2007 Nov; 3(11):758-68. PMID: 17955017.
      View in: PubMed
    22. Zhong L, Georgia S, Tschen SI, Nakayama K, Nakayama K, Bhushan A. Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. J Clin Invest. 2007 Oct; 117(10):2869-76. PMID: 17823659; PMCID: PMC1964513.
      View in: PubMed, PubMed Central
    23. Butler AE, Huang A, Rao PN, Bhushan A, Hogan WJ, Rizza RA, Butler PC. Hematopoietic stem cells derived from adult donors are not a source of pancreatic beta-cells in adult nondiabetic humans. Diabetes. 2007 Jul; 56(7):1810-6. PMID: 17456852.
      View in: PubMed
    24. Georgia S, Bhushan A. p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes. 2006 Nov; 55(11):2950-6. PMID: 17065330.
      View in: PubMed
    25. Georgia S, Soliz R, Li M, Zhang P, Bhushan A. p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol. 2006 Oct 01; 298(1):22-31. PMID: 16899237.
      View in: PubMed
    26. Meier JJ, Bhushan A, Butler PC. The potential for stem cell therapy in diabetes. Pediatr Res. 2006 Apr; 59(4 Pt 2):65R-73R. PMID: 16549551.
      View in: PubMed
    27. Wang X, Ge S, Gonzalez I, McNamara G, Rountree CB, Xi KK, Huang G, Bhushan A, Crooks GM. Formation of pancreatic duct epithelium from bone marrow during neonatal development. Stem Cells. 2006 Feb; 24(2):307-14. PMID: 16510429.
      View in: PubMed
    28. Georgia S, Bhushan A. Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest. 2004 Oct; 114(7):963-8. PMID: 15467835; PMCID: PMC518666.
      View in: PubMed, PubMed Central
    29. Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R. Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development. 2001 Dec; 128(24):5109-17. PMID: 11748146.
      View in: PubMed
    30. Bhushan A, Chen Y, Vale W. Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos. Dev Biol. 1998 Aug 15; 200(2):260-8. PMID: 9705232.
      View in: PubMed
    31. Chen Y, Bhushan A, Vale W. Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):12938-43. PMID: 9371779; PMCID: PMC24242.
      View in: PubMed, PubMed Central
    32. Bhushan A, Lin HY, Lodish HF, Kintner CR. The transforming growth factor beta type II receptor can replace the activin type II receptor in inducing mesoderm. Mol Cell Biol. 1994 Jun; 14(6):4280-5. PMID: 8196664; PMCID: PMC358794.
      View in: PubMed, PubMed Central
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