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Mallar Bhattacharya, MD

TitleAssistant Professor
SchoolUCSF School of Medicine
DepartmentMedicine
Phone415-514-4275
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityB.A.1998
    Oxford UniversityM.Sc.1999
    Harvard UniversityM.D.2004Medical School
    Johns Hopkins HospitalResidency2007Internal Medicine
    University of California, San FranciscoFellowship2010Pulmonary and Critical Care

    Collapse Overview 
    Collapse Overview
    Dr. Bhattacharya is an Assistant Professor of Medicine in the Division of Pulmonary and Critical Care at UCSF Medical Center. He completed baccalaureate and medical degrees at Harvard University and an internship and residency on the Osler medical service at Johns Hopkins Hospital. He then went on to complete a clinical fellowship in pulmonary and critical care at UCSF, followed by research training in the laboratory of Dr. Dean Sheppard at the UCSF Lung Biology Center. He joined the faculty in 2012.

    Research Interests
    1) Airway Smooth Muscle: Asthma is a disease of dynamic airway narrowing. My laboratory studies the molecular determinants of airway smooth muscle contraction, ranging from specific contractile pathways to regulation of gene transcription in the setting of airway inflammation. Through this work, I hope to identify new targets for treatment of asthma.

    2) Acute lung injury: The endothelium maintains barrier integrity of the lung vasculature. My laboratory seeks to understand the mechanisms governing disruption of this barrier during acute lung injury in order to spur discovery of novel pathways for treatment of lung edema.


    Collapse Research 
    Collapse Research Activities and Funding
    The Regulation of RhoA Activation in Airway Smooth Muscle
    NIH/NHLBI R01HL131560May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    IQGAP1 In Vascular Barrier Regulation During Acute Lung Injury
    NIH/NHLBI K08HL114641Sep 1, 2012 - Jun 30, 2017
    Role: Principal Investigator
    Regulation of Endothelial Permeability by Integrin alpha-v beta-3
    NIH/NHLBI F32HL099026Jan 1, 2011 - Dec 31, 2011
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Bhattacharya M. Could a coffee a day keep the inflammasome away? Sci Transl Med. 2017 Feb 08; 9(376). PMID: 28179502.
      View in: PubMed
    2. Bhattacharya M. Mesenchymal metamorphosis. Sci Transl Med. 2016 Dec 21; 8(370):370ec202. PMID: 28003541.
      View in: PubMed
    3. Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D. IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest. 2014 Nov; 124(11):4895-8. PMID: 25271629; PMCID: PMC4347230.
    4. Su G, Atakilit A, Li JT, Wu N, Luong J, Chen R, Bhattacharya M, Sheppard D. Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin avß5. Crit Care Med. 2013 Feb; 41(2):546-53. PMID: 23263571.
      View in: PubMed
    5. Bhattacharya M, Su G, Su X, Oses-Prieto JA, Li JT, Huang X, Hernandez H, Atakilit A, Burlingame AL, Matthay MA, Sheppard D. IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Jul 01; 303(1):L12-9. PMID: 22561460; PMCID: PMC3426434.
    6. Su G, Atakilit A, Li JT, Wu N, Bhattacharya M, Zhu J, Shieh JE, Li E, Chen R, Sun S, Su CP, Sheppard D. Absence of integrin avß3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Am J Respir Crit Care Med. 2012 Jan 01; 185(1):58-66. PMID: 21980034; PMCID: PMC3262039.
    7. Sigle RO, Gil SG, Bhattacharya M, Ryan MC, Yang TM, Brown TA, Boutaud A, Miyashita Y, Olerud J, Carter WG. Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5. J Cell Sci. 2004 Sep 01; 117(Pt 19):4481-94. PMID: 15316072.
      View in: PubMed
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