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Martin Valdearcos Contreras, PhD

Title(s)Assistant Professor, Diabetes Center
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-476-9847
ORCID ORCID Icon0000-0002-5784-2458 Additional info
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    My research interest focuses on the emerging field of neuro-immune interactions underlying obesity, and in particular how immunological and metabolic responses affect homeostasis and disease pathogenesis. I have a particular interest in understanding how CNS myeloid cells sense metabolic factors and interact with hypothalamic neurons to control energy and glucose homeostasis.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metab. 2017 Jul 05; 26(1):185-197.e3. Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK. PMID: 28683286.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    2. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Rep. 2017 06 13; 19(11):2257-2271. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. PMID: 28614713.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    3. Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. JCI Insight. 2017 04 06; 2(7):e91229. Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK. PMID: 28405620.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    4. Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity. Biochim Biophys Acta. 2016 09; 1861(9 Pt A):1083-1095. Peña L, Meana C, Astudillo AM, Lordén G, Valdearcos M, Sato H, Murakami M, Balsinde J, Balboa MA. PMID: 27317983.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    5. Saturated Fatty Acids Engage an IRE1a-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells. Cell Rep. 2016 Mar 22; 14(11):2611-23. Robblee MM, Kim CC, Porter Abate J, Valdearcos M, Sandlund KL, Shenoy MK, Volmer R, Iwawaki T, Koliwad SK. PMID: 26971994.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    6. Leptin potentiates astrogenesis in the developing hypothalamus. Mol Metab. 2015 Nov; 4(11):881-9. Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW. PMID: 26629411.
      View in: PubMed   Mentions: 11     Fields:    
    7. Hypothalamic inflammation in the control of metabolic function. Annu Rev Physiol. 2015; 77:131-60. Valdearcos M, Xu AW, Koliwad SK. PMID: 25668019.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    8. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep. 2014 Dec 24; 9(6):2124-38. Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK. PMID: 25497089.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    9. Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages. J Immunol. 2014 Nov 01; 193(9):4614-22. Meana C, Peña L, Lordén G, Esquinas E, Guijas C, Valdearcos M, Balsinde J, Balboa MA. PMID: 25252959.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    10. Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages. J Biol Chem. 2012 Mar 30; 287(14):10894-904. Valdearcos M, Esquinas E, Meana C, Peña L, Gil-de-Gómez L, Balsinde J, Balboa MA. PMID: 22334674.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    11. Subcellular localization and role of lipin-1 in human macrophages. J Immunol. 2011 May 15; 186(10):6004-13. Valdearcos M, Esquinas E, Meana C, Gil-de-Gómez L, Guijas C, Balsinde J, Balboa MA. PMID: 21478406.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    12. The cationic cluster of group IVA phospholipase A2 (Lys488/Lys541/Lys543/Lys544) is involved in translocation of the enzyme to phagosomes in human macrophages. J Lipid Res. 2010 Feb; 51(2):388-99. Casas J, Valdearcos M, Pindado J, Balsinde J, Balboa MA. PMID: 19717620.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. Requirement of JNK-mediated phosphorylation for translocation of group IVA phospholipase A2 to phagosomes in human macrophages. J Immunol. 2009 Aug 15; 183(4):2767-74. Casas J, Meana C, Esquinas E, Valdearcos M, Pindado J, Balsinde J, Balboa MA. PMID: 19625654.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
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