Martin Valdearcos, PhD

Title(s)Assistant Professor, Diabetes Center
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB, #1258
San Francisco CA 94143
Phone415-476-9847
ORCID ORCID Icon0000-0002-5784-2458 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Granada, Granada, SpainB.S.09/2005Biology
    Institute of Molecular Biology and Genetics, Valladolid, SpainPh.D.04/2011Innate immunity and lipid metabolism
    University of California San Francisco, San Francisco, CAPostdoc09/2017Obesity and Diabetes
    University of California, San Francisco, CA2021Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    Microglia are emerging as critical regulators of brain homeostasis with an expanding array of functions beyond their established roles as immune sentinels such as synaptic remodeling, neuronal excitability, and myelin plasticity. These highly dynamic cells continuously monitor their microenvironment for alterations, and distinct populations and activation states have been identified based on brain anatomical location, sex, and age. While microglia can respond to both local cues and peripheral factors, the complete repertoire of signals and transduction cascades governing their function remains to be elucidated. We recently showed that microglia are involved in the hypothalamic regulation of energy and glucose homeostasis. However, the cellular and molecular mechanisms by which microglial dysfunction contributes to metabolic disease are poorly understood. Our laboratory is dedicated to unraveling the functional heterogeneity of microglia, exploring their regulation by nutritional and metabolic signals, and understanding their interactions with other glial cells and neurons in the control of metabolic function
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Identification of AgRP cells in the murine hindbrain that drive feeding. Mol Metab. 2024 Feb; 80:101886. Bachor TP, Hwang E, Yulyaningsih E, Attal K, Mifsud F, Pham V, Vagena E, Huarcaya R, Valdearcos M, Vaisse C, Williams KW, Emmerson PJ, Xu AW. PMID: 38246589; PMCID: PMC10844855.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance. Cell Metab. 2023 09 05; 35(9):1613-1629.e8. Douglass JD, Ness KM, Valdearcos M, Wyse-Jackson A, Dorfman MD, Frey JM, Fasnacht RD, Santiago OD, Niraula A, Banerjee J, Robblee M, Koliwad SK, Thaler JP. PMID: 37572666; PMCID: PMC10528677.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis. Sci Signal. 2022 05 10; 15(733):eabj8204. Vagena E, Crneta J, Engström P, He L, Yulyaningsih E, Korpel NL, Cheang RT, Bachor TP, Huang A, Michel G, Attal K, Berrios DI, Valdearcos M, Koliwad SK, Olson DP, Yi CX, Xu AW. PMID: 35536884.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. Metabolic factors in the regulation of hypothalamic innate immune responses in obesity. Exp Mol Med. 2022 04; 54(4):393-402. Folick A, Cheang RT, Valdearcos M, Koliwad SK. PMID: 35474339; PMCID: PMC9076660.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis. Front Endocrinol (Lausanne). 2021; 12:668396. Folick A, Koliwad SK, Valdearcos M. PMID: 34122343; PMCID: PMC8191416.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    6. Blocking Kv1.3 potassium channels prevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice. Br J Anaesth. 2020 09; 125(3):298-307. Lai IK, Valdearcos M, Morioka K, Saxena S, Feng X, Li R, Uchida Y, Lijun A, Li W, Pan J, Koliwad S, Marcucio R, Wulff H, Maze M. PMID: 32624183; PMCID: PMC7497028.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    7. mTORC1 to AMPK switching underlies β-cell metabolic plasticity during maturation and diabetes. J Clin Invest. 2019 07 02; 129(10):4124-4137. Jaafar R, Tran S, Shah AN, Sun G, Valdearcos M, Marchetti P, Masini M, Swisa A, Giacometti S, Bernal-Mizrachi E, Matveyenko A, Hebrok M, Dor Y, Rutter GA, Koliwad SK, Bhushan A. PMID: 31265435; PMCID: PMC6763225.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    8. Hypothalamic microglia as potential regulators of metabolic physiology. Nat Metab. 2019 03; 1(3):314-320. Valdearcos M, Myers MG, Koliwad SK. PMID: 32694719.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    9. Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metab. 2018 Jun 05; 27(6):1356. Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK. PMID: 29874568.
      View in: PubMed   Mentions: 18     Fields:    
    10. Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice. Br J Anaesth. 2018 Mar; 120(3):537-545. Hu J, Feng X, Valdearcos M, Lutrin D, Uchida Y, Koliwad SK, Maze M. PMID: 29452810; PMCID: PMC6200097.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    11. Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility. Cell Metab. 2017 Jul 05; 26(1):185-197.e3. Valdearcos M, Douglass JD, Robblee MM, Dorfman MD, Stifler DR, Bennett ML, Gerritse I, Fasnacht R, Barres BA, Thaler JP, Koliwad SK. PMID: 28683286; PMCID: PMC5569901.
      View in: PubMed   Mentions: 191     Fields:    Translation:AnimalsCells
    12. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Rep. 2017 06 13; 19(11):2257-2271. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. PMID: 28614713; PMCID: PMC5651178.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    13. Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice. JCI Insight. 2017 04 06; 2(7):e91229. Feng X, Valdearcos M, Uchida Y, Lutrin D, Maze M, Koliwad SK. PMID: 28405620; PMCID: PMC5374063.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    14. Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity. Biochim Biophys Acta. 2016 09; 1861(9 Pt A):1083-1095. Peña L, Meana C, Astudillo AM, Lordén G, Valdearcos M, Sato H, Murakami M, Balsinde J, Balboa MA. PMID: 27317983.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    15. Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells. Cell Rep. 2016 Mar 22; 14(11):2611-23. Robblee MM, Kim CC, Porter Abate J, Valdearcos M, Sandlund KL, Shenoy MK, Volmer R, Iwawaki T, Koliwad SK. PMID: 26971994; PMCID: PMC5242525.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    16. Leptin potentiates astrogenesis in the developing hypothalamus. Mol Metab. 2015 Nov; 4(11):881-9. Rottkamp DM, Rudenko IA, Maier MT, Roshanbin S, Yulyaningsih E, Perez L, Valdearcos M, Chua S, Koliwad SK, Xu AW. PMID: 26629411; PMCID: PMC4632125.
      View in: PubMed   Mentions: 17     Fields:    
    17. Hypothalamic inflammation in the control of metabolic function. Annu Rev Physiol. 2015; 77:131-60. Valdearcos M, Xu AW, Koliwad SK. PMID: 25668019.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    18. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Rep. 2014 Dec 24; 9(6):2124-38. Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK. PMID: 25497089; PMCID: PMC4617309.
      View in: PubMed   Mentions: 260     Fields:    Translation:AnimalsCells
    19. Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages. J Immunol. 2014 Nov 01; 193(9):4614-22. Meana C, Peña L, Lordén G, Esquinas E, Guijas C, Valdearcos M, Balsinde J, Balboa MA. PMID: 25252959.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    20. Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages. J Biol Chem. 2012 Mar 30; 287(14):10894-904. Valdearcos M, Esquinas E, Meana C, Peña L, Gil-de-Gómez L, Balsinde J, Balboa MA. PMID: 22334674; PMCID: PMC3322858.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    21. Subcellular localization and role of lipin-1 in human macrophages. J Immunol. 2011 May 15; 186(10):6004-13. Valdearcos M, Esquinas E, Meana C, Gil-de-Gómez L, Guijas C, Balsinde J, Balboa MA. PMID: 21478406.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    22. The cationic cluster of group IVA phospholipase A2 (Lys488/Lys541/Lys543/Lys544) is involved in translocation of the enzyme to phagosomes in human macrophages. J Lipid Res. 2010 Feb; 51(2):388-99. Casas J, Valdearcos M, Pindado J, Balsinde J, Balboa MA. PMID: 19717620; PMCID: PMC2803241.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    23. Requirement of JNK-mediated phosphorylation for translocation of group IVA phospholipase A2 to phagosomes in human macrophages. J Immunol. 2009 Aug 15; 183(4):2767-74. Casas J, Meana C, Esquinas E, Valdearcos M, Pindado J, Balsinde J, Balboa MA. PMID: 19625654.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
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