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Ben Cheyette

Title(s)Professor Emeritus, Psychiatry
SchoolSchool of Medicine
Phone415-476-7826
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    Collapse Biography 
    Collapse Education and Training
    University of California Los AngelesM.D.1995David Geffen School of Medicine
    University of California Los AngelesPh.D1994Molecular Biology
    Princeton UniversityA.B.1988Biology
    University of WashingtonPostdoctoral Research Fellowship2002Molecular Pharmacology
    University of WashingtonClinical Specialty Training1999Psychiatry
    Collapse Awards and Honors
    UCSF2014  - 2016NARSAD Independent Investigator Award
    UW & University of California, San Francisco2001  - 2003NARSAD Young Investigator Award
    University of Washington (UW)1999  - 2001NARSAD Young Investigator Award
    University of Washington, Psychiatry1999Academic Excellence
    American Psychiatric Association1998Excellence in Psychiatry Residency
    National Institute of Mental Health1997Special Achievement as a Resident in Psychiatry
    UCLA School of Medicine1995Emil Bogen Prize for Outstanding Research Achievement
    Princeton University1988Charles M. Cannon Prize for Research Achievement
    Princeton University1988Sigma Xi National Scientific Honor Society
    Princeton University1988Magna Cum Laude, Biology
    -1984National Merit Scholar

    Collapse Research 
    Collapse Research Activities and Funding
    Autism-specific mutation in DACT1: Impact on brain development in a mouse model
    NIH R21MH085995Jun 8, 2009 - May 31, 2011
    Role: Principal Investigator
    The Dact/Sestd1 pathway in embryonic malformations
    NIH R01HD055300May 1, 2007 - Apr 30, 2018
    Role: Principal Investigator
    PROTEINS INTERACTING WITH DISHEVELLED IN VERTEBRATES
    NIH K08MH001750Sep 5, 1999 - Jul 31, 2004
    Role: Principal Investigator
    ROLE OF THE DROSOPHILA MED GENE IN AXON CONNECTIONS
    NIH F31MH010234Mar 27, 1991
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR. Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation. Cereb Cortex. 2019 Feb 01; 29(2):505-516. PMID: 29293918.
      View in: PubMed
    2. Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR. Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation. Cereb Cortex. 2018 Feb 21. PMID: 29474518.
      View in: PubMed
    3. Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR.Sestd1 encodes a developmentally dynamic synapse protein that complexes with BCR Rac1-GAP to regulate forebrain dendrite, spine and synapse formation. Cerebral Cortex. 2017.
      View Publication
    4. Mulligan KA, Cheyette BN. Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry. Mol Neuropsychiatry. 2017 Feb; 2(4):219-246. PMID: 28277568.
      View in: PubMed
    5. Martin PM, Stanley RE, Ross AP, Freitas AE, Moyer CE, Brumback AC, Iafrati J, Stapornwongkul KS, Dominguez S, Kivimäe S, Mulligan KA, Pirooznia M, McCombie WR, Potash JB, Zandi PP, Purcell SM, Sanders SJ, Zuo Y, Sohal VS, Cheyette BNR. DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/ß-catenin signaling. Mol Psychiatry. 2018 02; 23(2):467-475. PMID: 27752079.
      View in: PubMed
    6. Cheyette BN, Cheyette SN.Acute exacerbation of irritable bowel syndrome prevented by prn oral triptan. Clin J Gastroenterology. 2016; 6(9):375-378; PMID: 27699640 .
      View Publication
    7. Mulligan K, Cheyette BN."The Wnt Signaling Pathways." In R. P. Erickson & A. J. Wynshaw-Boris (Eds.) Inborn Errors of Development, 3rd edition. 2016; 323-329.
    8. Okerlund ND, Stanley RE, Cheyette BN. The Planar Cell Polarity Transmembrane Protein Vangl2 Promotes Dendrite, Spine and Glutamatergic Synapse Formation in the Mammalian Forebrain. Mol Neuropsychiatry. 2016 Jul; 2(2):107-14. PMID: 27606324; PMCID: PMC4996007 [Available on 07/01/17].
      View in: PubMed, PubMed Central
    9. Cheyette SR, Johnson P, Cheyette BN.ADHD & The Focused Mind. 2016; 260 pages. Print..
    10. Yang X, Fisher DA, Cheyette BN. SEC14 and Spectrin Domains 1 (Sestd1), Dishevelled 2 (Dvl2) and Dapper Antagonist of Catenin-1 (Dact1) co-regulate the Wnt/Planar Cell Polarity (PCP) pathway during mammalian development. Commun Integr Biol. 2013 Nov 01; 6(6):e26834. PMID: 24505507; PMCID: PMC3914910.
      View in: PubMed, PubMed Central
    11. Arguello A, Cheyette BN. Dapper Antagonist of Catenin-1 (Dact1) contributes to dendrite arborization in forebrain cortical interneurons. Commun Integr Biol. 2013 Nov 01; 6(6):e26656. PMID: 24567777; PMCID: PMC3925456.
      View in: PubMed, PubMed Central
    12. Martin PM, Yang X, Robin N, Lam E, Rabinowitz JS, Erdman CA, Quinn J, Weiss LA, Hamilton SP, Kwok PY, Moon RT, Cheyette BN. A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation. Transl Psychiatry. 2013 Sep 03; 3:e301. PMID: 24002087; PMCID: PMC3784764.
      View in: PubMed, PubMed Central
    13. Arguello A, Yang X, Vogt D, Stanco A, Rubenstein JL, Cheyette BN. Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons. PLoS One. 2013; 8(6):e67679. PMID: 23826333; PMCID: PMC3691262.
      View in: PubMed, PubMed Central
    14. Yang X, Cheyette BN. SEC14 and spectrin domains 1 (Sestd1) and Dapper antagonist of catenin 1 (Dact1) scaffold proteins cooperatively regulate the Van Gogh-like 2 (Vangl2) four-pass transmembrane protein and planar cell polarity (PCP) pathway during embryonic development in mice. J Biol Chem. 2013 Jul 12; 288(28):20111-20. PMID: 23696638; PMCID: PMC3711279.
      View in: PubMed, PubMed Central
    15. Mulligan KA, Cheyette BN. Wnt signaling in vertebrate neural development and function. J Neuroimmune Pharmacol. 2012 Dec; 7(4):774-87. PMID: 23015196; PMCID: PMC3518582.
      View in: PubMed, PubMed Central
    16. Kivimäe S, Martin PM, Kapfhamer D, Ruan Y, Heberlein U, Rubenstein JL, Cheyette BN. Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1. Transl Psychiatry. 2011 Sep 27; 1:e43. PMID: 22832659; PMCID: PMC3309484.
      View in: PubMed, PubMed Central
    17. Kivimäe S, Yang XY, Cheyette BN. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. BMC Biochem. 2011 Jun 30; 12:33. PMID: 21718540; PMCID: PMC3141656.
      View in: PubMed, PubMed Central
    18. Okerlund ND, Cheyette BN. Synaptic Wnt signaling-a contributor to major psychiatric disorders? J Neurodev Disord. 2011 Jun; 3(2):162-74. PMID: 21533542.
      View in: PubMed
    19. Okerlund ND, Kivimäe S, Tong CK, Peng IF, Ullian EM, Cheyette BN. Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain. J Neurosci. 2010 Mar 24; 30(12):4362-8. PMID: 20335472.
      View in: PubMed
    20. Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K. Dact1-3 mRNAs exhibit distinct expression domains during tooth development. Gene Expr Patterns. 2010 Feb-Mar; 10(2-3):140-3. PMID: 20170752; PMCID: PMC2849867.
      View in: PubMed, PubMed Central
    21. Suriben R, Kivimäe S, Fisher DA, Moon RT, Cheyette BN. Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet. 2009 Sep; 41(9):977-85. PMID: 19701191; PMCID: PMC2733921.
      View in: PubMed, PubMed Central
    22. Louie SH, Yang XY, Conrad WH, Muster J, Angers S, Moon RT, Cheyette BN. Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. PLoS One. 2009; 4(2):e4310. PMID: 19183803; PMCID: PMC2629544.
      View in: PubMed, PubMed Central
    23. Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, Nora ED, Campbell M, Medina-Gomez G, Cheyette BN, Vidal-Puig AJ, Sethi JK. Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network. Diabetes. 2009 Mar; 58(3):609-19. PMID: 19073771; PMCID: PMC2646059.
      View in: PubMed, PubMed Central
    24. Okerlund N, Cheyette BN."Wnt Signaling." In S. Offermanns & W. Rosenthal (Eds.) Encyclopedia of Molecular Pharmacology, 2nd edition. 2008; 1316-1322.
    25. Jiang X, Tan J, Li J, Kivimäe S, Yang X, Zhuang L, Lee PL, Chan MT, Stanton LW, Liu ET, Cheyette BN, Yu Q. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell. 2008 Jun; 13(6):529-41. PMID: 18538736; PMCID: PMC2577847.
      View in: PubMed, PubMed Central
    26. Cheyette BN, Cheyette SN, Cusmano-Ozog K, Enns GM. Dopa-responsive dystonia presenting as delayed and awkward gait. Pediatr Neurol. 2008 Apr; 38(4):273-5. PMID: 18358407.
      View in: PubMed
    27. Suriben R, Fisher DA, Cheyette BN. Dact1 presomitic mesoderm expression oscillates in phase with Axin2 in the somitogenesis clock of mice. Dev Dyn. 2006 Nov; 235(11):3177-83. PMID: 17013874.
      View in: PubMed
    28. Fisher DA, Kivimäe S, Hoshino J, Suriben R, Martin PM, Baxter N, Cheyette BN. Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. Dev Dyn. 2006 Sep; 235(9):2620-30. PMID: 16881060.
      View in: PubMed
    29. Kovoor A, Seyffarth P, Ebert J, Barghshoon S, Chen CK, Schwarz S, Axelrod JD, Cheyette BN, Simon MI, Lester HA, Schwarz J. D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. J Neurosci. 2005 Feb 23; 25(8):2157-65. PMID: 15728856.
      View in: PubMed
    30. Cheyette BN. Ryk: another heretical Wnt receptor defies the canon. Sci STKE. 2004 Dec 14; 2004(263):pe54. PMID: 15598975.
      View in: PubMed
    31. Cheyette BN and Moon RT."Wnt Protein Family." In H. L. Henry & A. W. Norman (Eds.) Encyclopedia of Hormones, vol. 3. 2003; 665-674.
    32. Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev Cell. 2002 Apr; 2(4):449-61. PMID: 11970895.
      View in: PubMed
    33. Cheyette BN, Green PJ, Martin K, Garren H, Hartenstein V, Zipursky SL. The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. Neuron. 1994 May; 12(5):977-96. PMID: 7910468.
      View in: PubMed
    34. Ebens AJ, Garren H, Cheyette BN, Zipursky SL. The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation. Cell. 1993 Jul 16; 74(1):15-27. PMID: 7916657.
      View in: PubMed
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