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Ben Cheyette

Title(s)Professor Emeritus, Psychiatry
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-476-7899
ORCID ORCID Icon0000-0001-9934-7941 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California Los AngelesM.D.1995David Geffen School of Medicine
    University of California Los AngelesPh.D1994Molecular Biology
    Princeton UniversityA.B.1988Biology
    University of WashingtonPostdoctoral Research Fellowship2002Molecular Pharmacology
    University of WashingtonClinical Specialty Training1999Psychiatry
    Collapse Awards and Honors
    UCSF2014  - 2016NARSAD Independent Investigator Award
    UW & University of California, San Francisco2001  - 2003NARSAD Young Investigator Award
    University of Washington (UW)1999  - 2001NARSAD Young Investigator Award
    University of Washington, Psychiatry1999Academic Excellence
    American Psychiatric Association1998Excellence in Psychiatry Residency
    National Institute of Mental Health1997Special Achievement as a Resident in Psychiatry
    UCLA School of Medicine1995Emil Bogen Prize for Outstanding Research Achievement
    Princeton University1988Charles M. Cannon Prize for Research Achievement
    Princeton University1988Sigma Xi National Scientific Honor Society
    Princeton University1988Magna Cum Laude, Biology
    -1984National Merit Scholar

    Collapse Research 
    Collapse Research Activities and Funding
    Autism-specific mutation in DACT1: Impact on brain development in a mouse model
    NIH R21MH085995Jun 8, 2009 - May 31, 2011
    Role: Principal Investigator
    The Dact/Sestd1 pathway in embryonic malformations
    NIH R01HD055300May 1, 2007 - Apr 30, 2018
    Role: Principal Investigator
    PROTEINS INTERACTING WITH DISHEVELLED IN VERTEBRATES
    NIH K08MH001750Sep 5, 1999 - Jul 31, 2004
    Role: Principal Investigator
    ROLE OF THE DROSOPHILA MED GENE IN AXON CONNECTIONS
    NIH F31MH010234Mar 27, 1991
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants. Cell Rep. 2020 04 14; 31(2):107495. Fazel Darbandi S, Robinson Schwartz SE, Pai EL, Everitt A, Turner ML, Cheyette BNR, Willsey AJ, State MW, Sohal VS, Rubenstein JLR. PMID: 32294447.
      View in: PubMed   Mentions: 1     Fields:    
    2. Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation. Cereb Cortex. 2019 03 01; 29(3):1217. Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR. PMID: 29474518.
      View in: PubMed   Mentions:    Fields:    
    3. Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation. Cereb Cortex. 2019 02 01; 29(2):505-516. Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR. PMID: 29293918.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Sestd1 encodes a developmentally dynamic synapse protein that complexes with BCR Rac1-GAP to regulate forebrain dendrite, spine and synapse formation. Cerebral Cortex. 2017. Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR. . View Publication.
    5. Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry. Mol Neuropsychiatry. 2017 Feb; 2(4):219-246. Mulligan KA, Cheyette BN. PMID: 28277568.
      View in: PubMed   Mentions:
    6. DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/ß-catenin signaling. Mol Psychiatry. 2018 02; 23(2):467-475. Martin PM, Stanley RE, Ross AP, Freitas AE, Moyer CE, Brumback AC, Iafrati J, Stapornwongkul KS, Dominguez S, Kivimäe S, Mulligan KA, Pirooznia M, McCombie WR, Potash JB, Zandi PP, Purcell SM, Sanders SJ, Zuo Y, Sohal VS, Cheyette BNR. PMID: 27752079.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    7. Acute exacerbation of irritable bowel syndrome prevented by prn oral triptan. Clin J Gastroenterology. 2016; 6(9):375-378; PMID: 27699640 . Cheyette BN, Cheyette SN. . View Publication.
    8. "The Wnt Signaling Pathways." In R. P. Erickson & A. J. Wynshaw-Boris (Eds.) Inborn Errors of Development, 3rd edition. 2016; 323-329. Mulligan K, Cheyette BN. .
    9. The Planar Cell Polarity Transmembrane Protein Vangl2 Promotes Dendrite, Spine and Glutamatergic Synapse Formation in the Mammalian Forebrain. Mol Neuropsychiatry. 2016 Jul; 2(2):107-14. Okerlund ND, Stanley RE, Cheyette BN. PMID: 27606324.
      View in: PubMed   Mentions:
    10. ADHD & The Focused Mind. 2016; 260 pages. Print.. Cheyette SR, Johnson P, Cheyette BN. .
    11. SEC14 and Spectrin Domains 1 (Sestd1), Dishevelled 2 (Dvl2) and Dapper Antagonist of Catenin-1 (Dact1) co-regulate the Wnt/Planar Cell Polarity (PCP) pathway during mammalian development. Commun Integr Biol. 2013 Nov 01; 6(6):e26834. Yang X, Fisher DA, Cheyette BN. PMID: 24505507.
      View in: PubMed   Mentions:
    12. Dapper Antagonist of Catenin-1 (Dact1) contributes to dendrite arborization in forebrain cortical interneurons. Commun Integr Biol. 2013 Nov 01; 6(6):e26656. Arguello A, Cheyette BN. PMID: 24567777.
      View in: PubMed   Mentions:
    13. A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation. Transl Psychiatry. 2013 Sep 03; 3:e301. Martin PM, Yang X, Robin N, Lam E, Rabinowitz JS, Erdman CA, Quinn J, Weiss LA, Hamilton SP, Kwok PY, Moon RT, Cheyette BN. PMID: 24002087.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    14. Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons. PLoS One. 2013; 8(6):e67679. Arguello A, Yang X, Vogt D, Stanco A, Rubenstein JL, Cheyette BN. PMID: 23826333.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    15. SEC14 and spectrin domains 1 (Sestd1) and Dapper antagonist of catenin 1 (Dact1) scaffold proteins cooperatively regulate the Van Gogh-like 2 (Vangl2) four-pass transmembrane protein and planar cell polarity (PCP) pathway during embryonic development in mice. J Biol Chem. 2013 Jul 12; 288(28):20111-20. Yang X, Cheyette BN. PMID: 23696638.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    16. Wnt signaling in vertebrate neural development and function. J Neuroimmune Pharmacol. 2012 Dec; 7(4):774-87. Mulligan KA, Cheyette BN. PMID: 23015196.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    17. Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1. Transl Psychiatry. 2011 Sep 27; 1:e43. Kivimäe S, Martin PM, Kapfhamer D, Ruan Y, Heberlein U, Rubenstein JL, Cheyette BN. PMID: 22832659.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    18. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. BMC Biochem. 2011 Jun 30; 12:33. Kivimäe S, Yang XY, Cheyette BN. PMID: 21718540.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    19. Synaptic Wnt signaling-a contributor to major psychiatric disorders? J Neurodev Disord. 2011 Jun; 3(2):162-74. Okerlund ND, Cheyette BN. PMID: 21533542.
      View in: PubMed   Mentions: 53     Fields:    
    20. Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain. J Neurosci. 2010 Mar 24; 30(12):4362-8. Okerlund ND, Kivimäe S, Tong CK, Peng IF, Ullian EM, Cheyette BN. PMID: 20335472.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    21. Dact1-3 mRNAs exhibit distinct expression domains during tooth development. Gene Expr Patterns. 2010 Feb-Mar; 10(2-3):140-3. Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K. PMID: 20170752.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    22. Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet. 2009 Sep; 41(9):977-85. Suriben R, Kivimäe S, Fisher DA, Moon RT, Cheyette BN. PMID: 19701191.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    23. Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. PLoS One. 2009; 4(2):e4310. Louie SH, Yang XY, Conrad WH, Muster J, Angers S, Moon RT, Cheyette BN. PMID: 19183803.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    24. Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network. Diabetes. 2009 Mar; 58(3):609-19. Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, Nora ED, Campbell M, Medina-Gomez G, Cheyette BN, Vidal-Puig AJ, Sethi JK. PMID: 19073771.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    25. "Wnt Signaling." In S. Offermanns & W. Rosenthal (Eds.) Encyclopedia of Molecular Pharmacology, 2nd edition. 2008; 1316-1322. Okerlund N, Cheyette BN. .
    26. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell. 2008 Jun; 13(6):529-41. Jiang X, Tan J, Li J, Kivimäe S, Yang X, Zhuang L, Lee PL, Chan MT, Stanton LW, Liu ET, Cheyette BN, Yu Q. PMID: 18538736.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    27. Dopa-responsive dystonia presenting as delayed and awkward gait. Pediatr Neurol. 2008 Apr; 38(4):273-5. Cheyette BN, Cheyette SN, Cusmano-Ozog K, Enns GM. PMID: 18358407.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. Dact1 presomitic mesoderm expression oscillates in phase with Axin2 in the somitogenesis clock of mice. Dev Dyn. 2006 Nov; 235(11):3177-83. Suriben R, Fisher DA, Cheyette BN. PMID: 17013874.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    29. Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. Dev Dyn. 2006 Sep; 235(9):2620-30. Fisher DA, Kivimäe S, Hoshino J, Suriben R, Martin PM, Baxter N, Cheyette BN. PMID: 16881060.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    30. D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. J Neurosci. 2005 Feb 23; 25(8):2157-65. Kovoor A, Seyffarth P, Ebert J, Barghshoon S, Chen CK, Schwarz S, Axelrod JD, Cheyette BN, Simon MI, Lester HA, Schwarz J. PMID: 15728856.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    31. Ryk: another heretical Wnt receptor defies the canon. Sci STKE. 2004 Dec 14; 2004(263):pe54. Cheyette BN. PMID: 15598975.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    32. "Wnt Protein Family." In H. L. Henry & A. W. Norman (Eds.) Encyclopedia of Hormones, vol. 3. 2003; 665-674. Cheyette BN and Moon RT. .
    33. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. Dev Cell. 2002 Apr; 2(4):449-61. Cheyette BN, Waxman JS, Miller JR, Takemaru K, Sheldahl LC, Khlebtsova N, Fox EP, Earnest T, Moon RT. PMID: 11970895.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    34. Homeobox genes and connective tissue patterning. Development. 1995 Mar; 121(3):693-705. Oliver G, Wehr R, Jenkins NA, Copeland NG, Cheyette BN, Hartenstein V, Zipursky SL, Gruss P. PMID: 7720577.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    35. The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. Neuron. 1994 May; 12(5):977-96. Cheyette BN, Green PJ, Martin K, Garren H, Hartenstein V, Zipursky SL. PMID: 7910468.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    36. The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation. Cell. 1993 Jul 16; 74(1):15-27. Ebens AJ, Garren H, Cheyette BN, Zipursky SL. PMID: 7916657.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
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