Daniel Santi, MD, PhD

Title(s)Professor Emeritus, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address600 16th Street, #S572A
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1980 Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Santi received a Ph.D. in Medicinal Chemistry from SUNY in 1967 and a M.D. from UCSF in 1981. He was Assistant Professor of Chemistry at UCSB from 1968 to 1974. He joined the UCSF faculty in 1974 and was Professor of Biochemistry and Biophysics, and of Pharmaceutical Chemistry at UCSF until 2000 when he became CEO of Kosan Biosciences. He returned to UCSF in 2007 where he served as interim Director of the UCSF CTSI and then Director of Translational Research at QB3. He became an Associate Dean of External Relationships in the School of Pharmacy in 2009, and manages an Industry Outreach Program. Dr. Santi has published over 300 scientific papers and is co-inventor on over 40 US patents.

    Santi was a member of the original Scientific Advisory Board of Chiron Corp. and has co-founded five biotechnology companies. In 1988, he founded and was Chairman of the peptide-combinatorial chemistry company Protos Corp., which merged with Chiron in 1992. He was also a co-founder of Parnassus Pharmaceuticals, and of Prospect Genomics which merged with Structural Genomix in 2001. In 1996, he co-founded Kosan Biosciences where he served as CEO and Chairman until 2006 when Kosan was acquired by Bristol Myers Squibb. He co-founded the platform technology company ProLynx LLC in 2010, where he currently serves as President.

    Collapse Research 
    Collapse Research Activities and Funding
    Combinatorial Biosynthesis of Polyketides
    NIH R44GM075639Sep 1, 2005 - Mar 5, 2006
    Role: Principal Investigator
    NIH S10RR011422Jun 14, 1996 - Jun 13, 1997
    Role: Principal Investigator
    RNA Modification Enzymes: Methyltransferase/PSI-synthase
    NIH R01GM051232May 1, 1996 - May 31, 2013
    Role: Co-Principal Investigator
    NIH R01AI032784Sep 1, 1991 - May 31, 2000
    Role: Co-Principal Investigator
    NIH U01AI030261Sep 30, 1990 - Nov 30, 1994
    Role: Principal Investigator
    NIH S10RR005670Jun 6, 1990 - Jun 5, 1991
    Role: Principal Investigator
    NIH S10RR003837Apr 4, 1988 - Apr 3, 1991
    Role: Principal Investigator
    NIH R01AI023972Aug 1, 1987 - Jul 31, 1990
    Role: Principal Investigator
    NIH R01AI019358Sep 1, 1982 - Apr 30, 1997
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    NIH R01CA014394Sep 1, 1978 - Feb 28, 2002
    Role: Co-Principal Investigator
    NIH R37CA014394Sep 1, 1978 - Feb 28, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Long-Acting Poly(ADP-ribose) Polymerase Inhibitor Prodrug for Humans. Bioconjug Chem. 2024 Apr 09. Carreras CW, Fontaine SD, Reid RR, Ashley GW, Santi DV. PMID: 38591781.
      View in: PubMed   Mentions:
    2. Are they functional hypogonadal men? Testosterone serum levels unravel male idiopathic infertility subgroups. Endocrine. 2024 Feb 19. Spaggiari G, Costantino F, Dalla Valentina L, Romeo M, Furini C, Roli L, De Santis MC, Canu G, Trenti T, Granata ARM, Simoni M, Santi D. PMID: 38372906.
      View in: PubMed   Mentions:    Fields:    
    3. Could a Long-Acting Prodrug of SN-38 be Efficacious in Sacituzumab Govitecan-Resistant Tumors? BioDrugs. 2024 Mar; 38(2):171-176. Santi DV, Ashley GW, Cabel L, Bidard FC. PMID: 38236523; PMCID: PMC10912420.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Randomized double-blind placebo-controlled trial on levothyroxine and liothyronine combination therapy in totally thyroidectomized subjects: the LEVOLIO study. Eur J Endocrinol. 2024 Jan 03; 190(1):12-22. Brigante G, Santi D, Boselli G, Margiotta G, Corleto R, Monzani ML, Craparo A, Locaso M, Sperduti S, Roy N, Casarini L, Trenti T, Tagliavini S, De Santis MC, Roli L, Rochira V, Simoni M. PMID: 38124252.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Gonadotropins in the Management of Couple Infertility: Toward the Rational Use of an Empirical Therapy. Semin Reprod Med. 2023 Nov; 41(6):258-266. Romeo M, Donno V, Spaggiari G, Granata ARM, Simoni M, La Marca A, Santi D. PMID: 38158195.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Is weight loss a therapeutic tool in the management of male infertility? Maturitas. 2023 Dec 20; 107901. Santi D, Corona G. PMID: 38142157.
      View in: PubMed   Mentions:    Fields:    
    7. Microbiota Composition and Probiotics Supplementations on Sleep Quality-A Systematic Review and Meta-Analysis. Clocks Sleep. 2023 Dec 13; 5(4):770-792. Santi D, Debbi V, Costantino F, Spaggiari G, Simoni M, Greco C, Casarini L. PMID: 38131749; PMCID: PMC10742335.
      View in: PubMed   Mentions:
    8. APHRODITE criteria: addressing male patients with hypogonadism and/or infertility owing to altered idiopathic testicular function. Reprod Biomed Online. 2023 Oct 29; 48(4):103647. Esteves SC, Humaidan P, Ubaldi FM, Alviggi C, Antonio L, Barratt CLR, Behre HM, Jørgensen N, Pacey AA, Simoni M, Santi D. PMID: 38367592.
      View in: PubMed   Mentions:    Fields:    
    9. The chronic alcohol consumption influences the gonadal axis in men: Results from a meta-analysis. Andrology. 2023 Sep 14. Santi D, Cignarelli A, Baldi M, Sansone A, Spaggiari G, Simoni M, Corona G. PMID: 37705506.
      View in: PubMed   Mentions:    Fields:    
    10. Sperm Concentration Improvement May Be a Parameter Predicting Efficacy of FSH Therapy of Male Idiopathic Infertility. Cells. 2023 09 08; 12(18). Santi D, Spaggiari G, Dalla Valentina L, Romeo M, Nuzzo F, Serlenga L, Roli L, De Santis MC, Trenti T, Granata ARM, Simoni M. PMID: 37759459; PMCID: PMC10527800.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Alterations in the Menstrual Cycle as a Peculiar Sign of Type 1 Diabetes Mellitus: A Meta-analytic Approach. Can J Diabetes. 2024 Mar; 48(2):133-140.e2. Greco C, Cacciani M, Corleto R, Simoni M, Spaggiari G, Santi D. PMID: 37544478.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Genetic Variants of Gonadotropins and Their Receptors Could Influence Controlled Ovarian Stimulation: IVF Data from a Prospective Multicenter Study. Genes (Basel). 2023 06 15; 14(6). Alviggi C, Longobardi S, Papaleo E, Santi D, Alfano S, Vanni VS, Campitiello MR, De Rosa P, Strina I, Huhtaniemi I, Pursiheimo JP, D'Hooghe T, Humaidan P, Conforti A. PMID: 37372449; PMCID: PMC10298688.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    13. Does an increase in adipose tissue 'weight' affect male fertility? A systematic review and meta-analysis based on semen analysis performed using the WHO 2010 criteria. Andrology. 2024 Jan; 12(1):123-136. Santi D, Lotti F, Sparano C, Rastrelli G, Isidori AM, Pivonello R, Barbonetti A, Salonia A, Minhas S, Krausz C, Vignozzi L, Maggi M, Corona G. PMID: 37226894.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Semen Analysis in "Urology-Naïve" Patients: A Chance of Uroandrological Screening in Young Males. J Clin Med. 2023 Jun 01; 12(11). Puliatti S, Toso S, Ticonosco M, Rabito S, Sighinolfi MC, Ferrari R, Rochira V, Santi D, Trenti T, Navarra M, Ferretti S, Montano L, Micali S. PMID: 37298000; PMCID: PMC10253905.
      View in: PubMed   Mentions:
    15. A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors. Cancer Res Commun. 2023 05; 3(5):908-916. Fontaine SD, Carreras CW, Reid RR, Ashley GW, Santi DV. PMID: 37377899; PMCID: PMC10208276.
      View in: PubMed   Mentions: Translation:HumansAnimals
    16. Talking about sex: erectile dysfunction in the oncology patient. Endocr Relat Cancer. 2023 06 01; 30(6). Romeo M, Spaggiari G, Furini C, Granata ARM, Toss A, Simoni M, Santi D. PMID: 36971778.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Prolactin and spermatogenesis: new lights on the interplay between prolactin and sperm parameters. Endocrine. 2023 08; 81(2):330-339. Spaggiari G, Costantino F, Granata ARM, Tagliavini S, Canu G, Varani M, De Santis MC, Roli L, Trenti T, Simoni M, Santi D. PMID: 37140814.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    18. Glycemic control predicts SARS-CoV-2 prognosis in diabetic subjects. Acta Diabetol. 2023 Jun; 60(6):817-825. Greco C, Pirotti T, Brigante G, Filippini T, Pacchioni C, Trenti T, Simoni M, Santi D. PMID: 36939895; PMCID: PMC10025792.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    19. Exploring the human chorionic gonadotropin induced steroid secretion profile of mouse Leydig tumor cell line 1 by a 20 steroid LC-MS/MS panel. J Steroid Biochem Mol Biol. 2023 05; 229:106270. Fanelli F, Magagnoli M, Mezzullo M, Lispi M, Limoncella S, Tommasini A, Pelusi C, Santi D, Simoni M, Pagotto U, Casarini L. PMID: 36764496.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    20. Systematic review and meta-analysis of long-term reintervention following thoracic endovascular repair for blunt traumatic aortic injury. J Vasc Surg. 2023 08; 78(2):540-547.e4. Gennai S, Leone N, Mezzetto L, Veraldi GF, Santi D, Spaggiari G, Resch T, Silingardi R. PMID: 36754248.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Not only a matter of glucose: The andrological consequences of diabetes mellitus. Andrology. 2023 02; 11(2):201-203. Rastrelli G, Santi D. PMID: 36642980.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Determinants of sexual function in men living with HIV younger than 50 years old: Focus on organic, relational, and psychological issues. Andrology. 2023 09; 11(6):954-969. De Vincentis S, Decaroli MC, Milic J, Fanelli F, Tartaro G, Diazzi C, Mezzullo M, De Santis MC, Roli L, Trenti T, Santi D, Pagotto U, Guaraldi G, Rochira V. PMID: 36585963.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Male infertility and gonadotropin treatment: What can we learn from real-world data? Best Pract Res Clin Obstet Gynaecol. 2023 Feb; 86:102310. Esteves SC, Achermann APP, Simoni M, Santi D, Casarini L. PMID: 36682942.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. Very low-calorie ketogenic diet rapidly augments testosterone levels in non-diabetic obese subjects. Andrology. 2023 02; 11(2):234-244. Cignarelli A, Santi D, Genchi VA, Conte E, Giordano F, Di Leo S, Natalicchio A, Laviola L, Giorgino F, Perrini S. PMID: 36459060.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. Follicle-stimulating hormone effectiveness in male idiopathic infertility: What happens in daily practice? Andrology. 2023 03; 11(3):478-488. Romeo M, Spaggiari G, Nuzzo F, Granata ARM, Simoni M, Santi D. PMID: 36424882.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. PLX038: A Long-Acting Topoisomerase I Inhibitor With Robust Antitumor Activity in ATM-Deficient Tumors and Potent Synergy With PARP Inhibitors. Mol Cancer Ther. 2022 11 03; 21(11):1722-1728. Thomas A, Fontaine SD, Diolaiti ME, Desai P, Kumar R, Takahashi N, Sciuto L, Nichols S, Ashworth A, Feng FY, Ashley GW, Nguyen M, Pommier Y, Santi DV. PMID: 35999657; PMCID: PMC10673686.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    27. Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers. ACS Appl Mater Interfaces. 2022 Nov 16; 14(45):50569-50582. Meher N, Ashley GW, Bidkar AP, Dhrona S, Fong C, Fontaine SD, Beckford Vera DR, Wilson DM, Seo Y, Santi DV, VanBrocklin HF, Flavell RR. PMID: 36318757; PMCID: PMC9673064.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. Which sperm parameter limits could really guide the clinical decision in assisted reproduction? Andrology. 2023 01; 11(1):143-154. Santi D, Spaggiari G, Morini D, Melli B, Dalla Valentina L, Aguzzoli L, Simoni M, Villani MT. PMID: 36251334.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    29. Testosterone Serum Levels Are Related to Sperm DNA Fragmentation Index Reduction after FSH Administration in Males with Idiopathic Infertility. Biomedicines. 2022 Oct 17; 10(10). Lispi M, Drakopoulos P, Spaggiari G, Caprio F, Colacurci N, Simoni M, Santi D. PMID: 36289860; PMCID: PMC9599665.
      View in: PubMed   Mentions: 5  
    30. Ketogenic state improves testosterone serum levels-results from a systematic review and meta-analysis. Endocrine. 2023 02; 79(2):273-282. Furini C, Spaggiari G, Simoni M, Greco C, Santi D. PMID: 36149528.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    31. Editorial: Follicle-stimulating hormone: Fertility and beyond-volume II. Front Endocrinol (Lausanne). 2022; 13:991106. Simoni M, Huhtaniemi I, Casarini L, Santi D. PMID: 35992096; PMCID: PMC9382242.
      View in: PubMed   Mentions:    Fields:    
    32. Neither rationale nor scientific evidence exist to support that double stimulation is potentially unsafe. Hum Reprod. 2022 Jul 30; 37(8):1949-1950. Casarini L, Vaiarelli A, Cimadomo D, Santi D, Simoni M, Garcìa-Velasco JA, Alviggi C, La Marca A, Rienzi L, Ubaldi FM. PMID: 35394501.
      View in: PubMed   Mentions: 1     Fields:    
    33. A long-acting C-natriuretic peptide for achondroplasia. Proc Natl Acad Sci U S A. 2022 07 26; 119(30):e2201067119. Schneider EL, Carreras CW, Reid R, Ashley GW, Santi DV. PMID: 35858423; PMCID: PMC9335275.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    34. Qualitative and quantitative analysis of doctor-patient interactions during andrological consultations. Andrology. 2022 10; 10(7):1240-1249. Santi D, Spaggiari G, Romeo M, Ebert R, Corradini F, Baraldi C, Granata ARM, Rochira V, Simoni M, Gavioli L, Niemants NSA. PMID: 35785424; PMCID: PMC9540423.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. Human fertility and sleep disturbances: A narrative review. Sleep Med. 2022 10; 98:13-25. Spaggiari G, Romeo M, Casarini L, Granata ARM, Simoni M, Santi D. PMID: 35772248.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. Diabetic Neuropathic Cachexia: A Clinical Case and Review of Literature. Life (Basel). 2022 May 04; 12(5). Bellelli A, Santi D, Simoni M, Greco C. PMID: 35629348; PMCID: PMC9147421.
      View in: PubMed   Mentions:
    37. Real-world evidence analysis of the follicle-stimulating hormone use in male idiopathic infertility. Best Pract Res Clin Obstet Gynaecol. 2022 Apr 29. Santi D, Spaggiari G, Granata ARM, Simoni M. PMID: 35618626.
      View in: PubMed   Mentions: 1     Fields:    
    38. Effect of the Glucagon-Like Peptide-1 Receptor Agonists on Autonomic Function in Subjects with Diabetes: A Systematic Review and Meta-Analysis. Diabetes Metab J. 2022 11; 46(6):901-911. Greco C, Santi D, Brigante G, Pacchioni C, Simoni M. PMID: 35410110; PMCID: PMC9723196.
      View in: PubMed   Mentions: 4  Translation:Humans
    39. Accurate and time-saving, two-step intracavernosal injection procedure to diagnose psychological erectile dysfunction. Andrology. 2022 07; 10(5):852-862. Santi D, Spaggiari G, Simoni M, Granata ARM. PMID: 35279959; PMCID: PMC9311207.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    40. First Year Metabolic and Hormonal Behavior Define two Different Populations of SGA Newborn for Weight or Height. J Endocr Soc. 2022 May 01; 6(5):bvac028. Guazzarotti L, Mauri S, Santi D, Pogliani L, Zuccotti G. PMID: 35350393; PMCID: PMC8944306.
      View in: PubMed   Mentions:
    41. Semen cryopreservation in men undergoing cancer treatment: a ten-year study. Minerva Obstet Gynecol. 2023 Jun; 75(3):227-235. Melli B, Morini D, Daolio J, Nicoli A, Valli B, Capodanno F, Spaggiari G, Aguzzoli L, Villani MT, Santi D, Sileo FG. PMID: 35107238.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. The (decision) tree of fertility: an innovative decision-making algorithm in assisted reproduction technique. J Assist Reprod Genet. 2022 Feb; 39(2):395-408. Villani MT, Morini D, Spaggiari G, Furini C, Melli B, Nicoli A, Iannotti F, La Sala GB, Simoni M, Aguzzoli L, Santi D. PMID: 35084638; PMCID: PMC8793814.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. Seasonal reproduction and gonadal function: a focus on humans starting from animal studies. Biol Reprod. 2022 01 13; 106(1):47-57. Beltran-Frutos E, Casarini L, Santi D, Brigante G. PMID: 34718419.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    44. A very long-acting IL-15: implications for the immunotherapy of cancer. J Immunother Cancer. 2022 01; 10(1). Hangasky JA, Chen W, Dubois SP, Daenthanasanmak A, Müller JR, Reid R, Waldmann TA, Santi DV. PMID: 35101947; PMCID: PMC8804710.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    45. From subjective to objective: A pilot study on testicular radiomics analysis as a measure of gonadal function. Andrology. 2022 03; 10(3):505-517. De Santi B, Spaggiari G, Granata AR, Romeo M, Molinari F, Simoni M, Santi D. PMID: 34817934; PMCID: PMC9299912.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    46. Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line. Mol Cell Endocrinol. 2022 02 15; 542:111527. Limoncella S, Lazzaretti C, Paradiso E, D'Alessandro S, Barbagallo F, Pacifico S, Guerrini R, Tagliavini S, Trenti T, Santi D, Simoni M, Sola M, Di Rocco G, Casarini L. PMID: 34875337.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    47. Are sperm parameters able to predict the success of assisted reproductive technology? A retrospective analysis of over 22,000 assisted reproductive technology cycles. Andrology. 2022 02; 10(2):310-321. Villani MT, Morini D, Spaggiari G, Falbo AI, Melli B, La Sala GB, Romeo M, Simoni M, Aguzzoli L, Santi D. PMID: 34723422; PMCID: PMC9298690.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    48. Association of Nonalcoholic Fatty Liver Disease (NAFLD) with Peripheral Diabetic Polyneuropathy: A Systematic Review and Meta-Analysis. J Clin Med. 2021 Sep 28; 10(19). Greco C, Nascimbeni F, Carubbi F, Andreone P, Simoni M, Santi D. PMID: 34640482; PMCID: PMC8509344.
      View in: PubMed   Mentions: 5  
    49. The Prevalence of Hypogonadism and the Effectiveness of Androgen Administration on Body Composition in HIV-Infected Men: A Meta-Analysis. Cells. 2021 08 12; 10(8). Santi D, Spaggiari G, Vena W, Pizzocaro A, Maggi M, Rochira V, Corona G. PMID: 34440836; PMCID: PMC8392149.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    50. Does sacituzumab-govitecan act as a conventional antibody drug conjugate (ADC), a prodrug of SN-38 or both? Ann Transl Med. 2021 Jul; 9(14):1113. Santi DV, Cabel L, Bidard FC. PMID: 34430554; PMCID: PMC8350658.
      View in: PubMed   Mentions: 9  
    51. Improvement of sperm morphology after surgical varicocele repair. Andrology. 2021 07; 9(4):1176-1184. Morini D, Spaggiari G, Daolio J, Melli B, Nicoli A, De Feo G, Valli B, Viola D, Garganigo S, Magnani E, Pilia A, Polese A, Colla R, Simoni M, Aguzzoli L, Villani MT, Santi D. PMID: 33825345; PMCID: PMC8360177.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    52. Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles. Bioconjug Chem. 2021 04 21; 32(4):794-800. Hearn BR, Fontaine SD, Schneider EL, Kraemer Y, Ashley GW, Santi DV. PMID: 33822591.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    53. A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males. Sci Rep. 2021 03 29; 11(1):7075. Brigante G, Spaggiari G, Rossi B, Granata A, Simoni M, Santi D. PMID: 33782499; PMCID: PMC8007755.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    54. Psychotropic Drugs Levels in Seminal Fluid: A New Therapeutic Drug Monitoring Analysis? Front Endocrinol (Lausanne). 2021; 12:620936. Mazzilli R, Curto M, De Bernardini D, Olana S, Capi M, Salerno G, Cipolla F, Zamponi V, Santi D, Mazzilli F, Simmaco M, Lionetto L. PMID: 33776918; PMCID: PMC7992038.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    55. HIV and Sexual Dysfunction in Men. J Clin Med. 2021 Mar 05; 10(5). De Vincentis S, Tartaro G, Rochira V, Santi D. PMID: 33807833; PMCID: PMC7961513.
      View in: PubMed   Mentions: 11  
    56. The "Hitchhiker's Guide to the Galaxy" of Endothelial Dysfunction Markers in Human Fertility. Int J Mol Sci. 2021 Mar 04; 22(5). Santi D, Spaggiari G, Greco C, Lazzaretti C, Paradiso E, Casarini L, Potì F, Brigante G, Simoni M. PMID: 33806677; PMCID: PMC7961823.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    57. Spontaneous pregnancies among infertile couples during assisted reproduction lockdown for COVID-19 pandemic. Andrology. 2021 07; 9(4):1038-1041. Villani MT, Morini D, Spaggiari G, Simoni M, Aguzzoli L, Santi D. PMID: 33427417; PMCID: PMC8014815.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    58. Gynecological malignancy mimicking a thyroid lymph node metastasis. Endocrinol Diabetes Metab Case Rep. 2021 Jan 11; 2021. Pederzoli S, Spaggiari G, Bernardelli G, Mattioli F, Baldessari C, Maiorana A, Rochira V, Santi D. PMID: 33431707; PMCID: PMC7849477.
      View in: PubMed   Mentions:
    59. Health status is related to testosterone, estrone and body fat: moving to functional hypogonadism in adult men with HIV. Eur J Endocrinol. 2021 Jan; 184(1):107-122. De Vincentis S, Decaroli MC, Fanelli F, Diazzi C, Mezzullo M, Morini F, Bertani D, Milic J, Carli F, Cuomo G, Santi D, Tartaro G, Tagliavini S, De Santis MC, Roli L, Trenti T, Pagotto U, Guaraldi G, Rochira V. PMID: 33112262.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    60. A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models. Cancer Res. 2021 02 15; 81(4):1076-1086. Fontaine SD, Ashley GW, Houghton PJ, Kurmasheva RT, Diolaiti M, Ashworth A, Peer CJ, Nguyen R, Figg WD, Beckford-Vera DR, Santi DV. PMID: 33323380; PMCID: PMC8670222.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    61. Elevated levels of nitrous dioxide are associated with lower AMH levels: a real-world analysis. Hum Reprod. 2020 11 01; 35(11):2589-2597. La Marca A, Spaggiari G, Domenici D, Grassi R, Casonati A, Baraldi E, Trenti T, Simoni M, Santi D. PMID: 32951044.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    62. Eating Behavior after Bariatric Surgery (EBBS) Questionnaire: a New Validated Tool to Quantify the Patients' Compliance to Post-Bariatric Dietary and Lifestyle Suggestions. Obes Surg. 2020 Oct; 30(10):3831-3838. Spaggiari G, Santi D, Budriesi G, Dondi P, Cavedoni S, Leonardi L, Delvecchio C, Valentini L, Bondi M, Miloro C, Toschi PF. PMID: 32447636.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    63. Interleukin 15 Pharmacokinetics and Consumption by a Dynamic Cytokine Sink. Front Immunol. 2020; 11:1813. Hangasky JA, Waldmann TA, Santi DV. PMID: 32903632; PMCID: PMC7438588.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    64. Effects of acute hCG stimulation on serum INSL3 and 25-OH vitamin D in Klinefelter syndrome. Andrology. 2020 11; 8(6):1720-1727. Santi D, Ivell R, Anand-Ivell R, De Toni L, Fanelli F, Mezzullo M, Pelusi C, Pagotto U, Belli S, Granata ARM, Roli L, Rochira V, Trenti T, Ferlin A, Simoni M. PMID: 32593193.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    65. Prospects for FSH Treatment of Male Infertility. J Clin Endocrinol Metab. 2020 07 01; 105(7). Simoni M, Brigante G, Rochira V, Santi D, Casarini L. PMID: 32374828.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    66. Multilevel approach to male fertility by machine learning highlights a hidden link between haematological and spermatogenetic cells. Andrology. 2020 09; 8(5):1021-1029. Santi D, Spaggiari G, Casonati A, Casarini L, Grassi R, Vecchi B, Roli L, De Santis MC, Orlando G, Gravotta E, Baraldi E, Setti M, Trenti T, Simoni M. PMID: 32449608.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    67. To beer or not to beer: A meta-analysis of the effects of beer consumption on cardiovascular health. PLoS One. 2020; 15(6):e0233619. Spaggiari G, Cignarelli A, Sansone A, Baldi M, Santi D. PMID: 32492025; PMCID: PMC7269243.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    68. Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation. Asian J Androl. 2020 May-Jun; 22(3):302-308. Spaggiari G, M Granata AR, Santi D. PMID: 31274478; PMCID: PMC7275802.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    69. Follicle-stimulating Hormone (FSH) Action on Spermatogenesis: A Focus on Physiological and Therapeutic Roles. J Clin Med. 2020 Apr 03; 9(4). Santi D, Crépieux P, Reiter E, Spaggiari G, Brigante G, Casarini L, Rochira V, Simoni M. PMID: 32260182; PMCID: PMC7230878.
      View in: PubMed   Mentions: 34  
    70. FSH for the Treatment of Male Infertility. Int J Mol Sci. 2020 Mar 25; 21(7). Casarini L, Crépieux P, Reiter E, Lazzaretti C, Paradiso E, Rochira V, Brigante G, Santi D, Simoni M. PMID: 32218314; PMCID: PMC7177393.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    71. The physician's gender influences the results of the diagnostic workup for erectile dysfunction. Andrology. 2020 05; 8(3):671-679. Rastrelli G, Cipriani S, Craparo A, De Vincentis S, Granata ARM, Spaggiari G, Simoni M, Maggi M, Santi D. PMID: 31955507.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    72. Prospective use of the single-mouse experimental design for the evaluation of PLX038A. Cancer Chemother Pharmacol. 2020 02; 85(2):251-263. Ghilu S, Li Q, Fontaine SD, Santi DV, Kurmasheva RT, Zheng S, Houghton PJ. PMID: 31927611; PMCID: PMC7039322.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    73. Seasonal Changes of Serum Gonadotropins and Testosterone in Men Revealed by a Large Data Set of Real-World Observations Over Nine Years. Front Endocrinol (Lausanne). 2019; 10:914. Santi D, Spaggiari G, Granata ARM, Setti M, Tagliavini S, Trenti T, Simoni M. PMID: 31998242; PMCID: PMC6965064.
      View in: PubMed   Mentions: 2     Fields:    
    74. FSH treatment of male idiopathic infertility: Time for a paradigm change. Andrology. 2020 05; 8(3):535-544. Simoni M, Santi D. PMID: 31872552.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    75. Use of follicle-stimulating hormone for the male partner of idiopathic infertile couples in Italy: Results from a multicentre, observational, clinical practice survey. Andrology. 2020 05; 8(3):637-644. Santi D, De Vincentis S, Alfano P, Balercia G, Calogero AE, Cargnelutti F, Coccia ME, Condorelli RA, Dal Lago A, de Angelis C, Gallo M, Iannantuoni N, Lombardo F, Marino A, Mazzella M, Pallotti F, Paoli D, Pivonello R, Rago R, Rampini M, Salvio G, Simoni M. PMID: 31872967.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    76. An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men. Andrology. 2020 01; 8(1):53-81. Esteves SC, Santi D, Simoni M. PMID: 31692293.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    77. PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89. Mol Cancer Ther. 2020 02; 19(2):673-679. Beckford Vera DR, Fontaine SD, VanBrocklin HF, Hearn BR, Reid R, Ashley GW, Santi DV. PMID: 31744896.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    78. PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity. Cancer Chemother Pharmacol. 2020 01; 85(1):225-229. Fontaine SD, Santi AD, Reid R, Smith PC, Ashley GW, Santi DV. PMID: 31707444.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    79. Editorial: Follicle-Stimulating Hormone: Fertility and Beyond. Front Endocrinol (Lausanne). 2019; 10:610. Simoni M, Huhtaniemi I, Santi D, Casarini L. PMID: 31551936; PMCID: PMC6748238.
      View in: PubMed   Mentions: 6     Fields:    
    80. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study. Endocr Connect. 2019 Aug 01; 8(8):1118-1125. Melcangi RC, Casarini L, Marino M, Santi D, Sperduti S, Giatti S, Diviccaro S, Grimoldi M, Caruso D, Cavaletti G, Simoni M. PMID: 31272082; PMCID: PMC6652249.
      View in: PubMed   Mentions: 2  
    81. Semi-annual seasonal pattern of serum thyrotropin in adults. Sci Rep. 2019 07 25; 9(1):10786. Santi D, Spaggiari G, Brigante G, Setti M, Tagliavini S, Trenti T, Simoni M. PMID: 31346248; PMCID: PMC6658473.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    82. Species-specific optimization of PEG~SN-38 prodrug pharmacokinetics and antitumor effects in a triple-negative BRCA1-deficient xenograft. Cancer Chemother Pharmacol. 2019 10; 84(4):729-738. Fontaine SD, Hann B, Reid R, Ashley GW, Santi DV. PMID: 31321449.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    83. Effect of treatment with testosterone on endothelial function in hypogonadal men: a systematic review and meta-analysis. Int J Impot Res. 2020 Jul; 32(4):379-386. Sansone A, Rastrelli G, Cignarelli A, de Rocco Ponce M, Condorelli RA, Giannetta E, Maseroli E, Pinto S, Salzano C, Santi D. PMID: 31235898.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    84. An Observational Retrospective Cohort Trial on 4,828 IVF Cycles Evaluating Different Low Prognosis Patients Following the POSEIDON Criteria. Front Endocrinol (Lausanne). 2019; 10:282. Levi-Setti PE, Zerbetto I, Baggiani A, Zannoni E, Sacchi L, Smeraldi A, Morenghi E, De Cesare R, Drovanti A, Santi D. PMID: 31139146; PMCID: PMC6517844.
      View in: PubMed   Mentions: 17     Fields:    
    85. Relative hyperestrogenism in Klinefelter Syndrome: results from a meta-analysis. Endocrine. 2019 05; 64(2):209-219. Santi D, De Vincentis S, Scaltriti S, Rochira V. PMID: 30701446.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    86. Expression and clinicopathological role of miR146a in thyroid follicular carcinoma. Endocrine. 2019 06; 64(3):575-583. Pignatti E, Vighi E, Magnani E, Kara E, Roncati L, Maiorana A, Santi D, Madeo B, Cioni K, Carani C, Rochira V, Simoni M, Brigante G. PMID: 30701447.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    87. Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis. Int J Mol Sci. 2019 Jan 16; 20(2). Potì F, Santi D, Spaggiari G, Zimetti F, Zanotti I. PMID: 30654461; PMCID: PMC6359281.
      View in: PubMed   Mentions: 79     Fields:    Translation:Humans
    88. Two Hormones for One Receptor: Evolution, Biochemistry, Actions, and Pathophysiology of LH and hCG. Endocr Rev. 2018 10 01; 39(5):549-592. Casarini L, Santi D, Brigante G, Simoni M. PMID: 29905829.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    89. Clinical relevance of genetic variants of gonadotrophins and their receptors in controlled ovarian stimulation: a systematic review and meta-analysis. Hum Reprod Update. 2018 09 01; 24(5):599-614. Alviggi C, Conforti A, Santi D, Esteves SC, Andersen CY, Humaidan P, Chiodini P, De Placido G, Simoni M. PMID: 29924306.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    90. A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules. Transl Vis Sci Technol. 2018 Jul; 7(4):21. Machinaga N, Ashley GW, Reid R, Yamasaki A, Tanaka K, Nakamura K, Yabe Y, Yoshigae Y, Santi DV. PMID: 30174998; PMCID: PMC6114027.
      View in: PubMed   Mentions: 3     Fields:    
    91. Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management - meta-analyses. Reprod Biomed Online. 2018 09; 37(3):315-326. Santi D, Spaggiari G, Simoni M. PMID: 30314886.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    92. Could chronic Vardenafil administration influence the cardiovascular risk in men with type 2 diabetes mellitus? PLoS One. 2018; 13(6):e0199299. Santi D, Locaso M, Granata AR, Trenti T, Roli L, Pacchioni C, Rochira V, Carani C, Simoni M. PMID: 29953477; PMCID: PMC6023114.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    93. AN ITALIAN SURVEY OF COMPLIANCE WITH MAJOR GUIDELINES FOR L-THYROXINE OF PRIMARY HYPOTHYROIDISM. Endocr Pract. 2018 May; 24(5):419-428. Vezzani S, Giannetta E, Altieri B, Barbonetti A, Bellastella G, Certo R, Cignarelli A, Cinti F, D'Andrea S, Di Dalmazi G, Frara S, Garelli S, Giuffrida G, Maiorino MI, Mele C, Mezza T, Pani MG, Samà MT, Satta C, Santi D. PMID: 29847168.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    94. Response: Commentary: Efficacy of Follicle-Stimulating Hormone (FSH) Alone, FSH + Luteinizing Hormone, Human Menopausal Gonadotropin or FSH + Human Chorionic Gonadotropin on Assisted Reproductive Technology Outcomes in the "Personalized" Medicine Era: A Meta-analysis. Front Endocrinol (Lausanne). 2018; 9:113. Santi D, Casarini L, Alviggi C, Simoni M. PMID: 29628912; PMCID: PMC5876307.
      View in: PubMed   Mentions: 4     Fields:    
    95. Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system. J Control Release. 2018 05 28; 278:74-79. Hearn BR, Fontaine SD, Pfaff SJ, Schneider EL, Henise J, Ashley GW, Santi DV. PMID: 29577950.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    96. Seasonal variation of semen parameters correlates with environmental temperature and air pollution: A big data analysis over 6 years. Environ Pollut. 2018 Apr; 235:806-813. Santi D, Magnani E, Michelangeli M, Grassi R, Vecchi B, Pedroni G, Roli L, De Santis MC, Baraldi E, Setti M, Trenti T, Simoni M. PMID: 29353799.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansPHPublic Health
    97. 'Spare' Luteinizing Hormone Receptors: Facts and Fiction. Trends Endocrinol Metab. 2018 04; 29(4):208-217. Casarini L, Santi D, Simoni M, Potì F. PMID: 29429918.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    98. Pharmacogenetics of G-protein-coupled receptors variants: FSH receptor and infertility treatment. Best Pract Res Clin Endocrinol Metab. 2018 04; 32(2):189-200. Santi D, Potì F, Simoni M, Casarini L. PMID: 29678285.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    99. Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment. Front Endocrinol (Lausanne). 2017; 8:316. Spaggiari G, Brigante G, De Vincentis S, Cattini U, Roli L, De Santis MC, Baraldi E, Tagliavini S, Varani M, Trenti T, Rochira V, Simoni M, Santi D. PMID: 29184537; PMCID: PMC5694461.
      View in: PubMed   Mentions: 15     Fields:    
    100. Serum Calcium to Phosphorous (Ca/P) Ratio Is a Simple, Inexpensive, and Accurate Tool in the Diagnosis of Primary Hyperparathyroidism. JBMR Plus. 2018 Mar; 2(2):109-117. Madeo B, Kara E, Cioni K, Vezzani S, Trenti T, Santi D, Simoni M, Rochira V. PMID: 30283895; PMCID: PMC6124174.
      View in: PubMed   Mentions: 16  
    101. Gene Expression and Apoptosis Levels in Cumulus Cells of Patients with Polymorphisms of FSHR and LHB Undergoing in Vitro Fertilization Program. Cell Physiol Biochem. 2017; 43(6):2391-2404. Bosco L, Ruvolo G, Luparello C, Ferrari S, Valerio D, Santi D, Piomboni P, Sarcina E, Lispi M, Roccheri MC. PMID: 29073627.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    102. Molecular basis of androgen action on human sexual desire. Mol Cell Endocrinol. 2018 05 15; 467:31-41. Santi D, Spaggiari G, Gilioli L, Potì F, Simoni M, Casarini L. PMID: 28893567.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    103. A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP-1 Receptor Agonist. ACS Chem Biol. 2017 08 18; 12(8):2107-2116. Schneider EL, Hearn BR, Pfaff SJ, Reid R, Parkes DG, Vrang N, Ashley GW, Santi DV. PMID: 28605180.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    104. Advances in Robotic Transaxillary Thyroidectomy in Europe. Curr Surg Rep. 2017; 5(8):17. Piccoli M, Mullineris B, Santi D, Gozzo D. PMID: 28680769; PMCID: PMC5488127.
      View in: PubMed   Mentions: 10  
    105. Efficacy of Follicle-Stimulating Hormone (FSH) Alone, FSH + Luteinizing Hormone, Human Menopausal Gonadotropin or FSH + Human Chorionic Gonadotropin on Assisted Reproductive Technology Outcomes in the "Personalized" Medicine Era: A Meta-analysis. Front Endocrinol (Lausanne). 2017; 8:114. Santi D, Casarini L, Alviggi C, Simoni M. PMID: 28620352; PMCID: PMC5451514.
      View in: PubMed   Mentions: 34     Fields:    
    106. Genetics of gonadotropins and their receptors as markers of ovarian reserve and response in controlled ovarian stimulation. Best Pract Res Clin Obstet Gynaecol. 2017 Oct; 44:15-25. Riccetti L, De Pascali F, Gilioli L, Santi D, Brigante G, Simoni M, Casarini L. PMID: 28506471.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    107. Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients. J Steroid Biochem Mol Biol. 2017 07; 171:229-235. Melcangi RC, Santi D, Spezzano R, Grimoldi M, Tabacchi T, Fusco ML, Diviccaro S, Giatti S, Carrà G, Caruso D, Simoni M, Cavaletti G. PMID: 28408350.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    108. Central hypogonadism due to a giant, "silent" FSH-secreting, atypical pituitary adenoma: effects of adenoma dissection and short-term Leydig cell stimulation by luteinizing hormone (LH) and human chorionic gonadotropin (hCG). Aging Male. 2017 Jun; 20(2):96-101. Santi D, Spaggiari G, Casarini L, Fanelli F, Mezzullo M, Pagotto U, Granata ARM, Carani C, Simoni M. PMID: 28067604.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    109. Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake. Bioconjug Chem. 2016 Oct 19; 27(10):2534-2539. Schneider EL, Hearn BR, Pfaff SJ, Fontaine SD, Reid R, Ashley GW, Grabulovski S, Strassberger V, Vogt L, Jung T, Santi DV. PMID: 27657443.
      View in: PubMed   Mentions: 3     Fields:    
    110. Effects of chronic administration of the phosphodiesterase inhibitor vardenafil on serum levels of adrenal and testicular steroids in men with type 2 diabetes mellitus. Endocrine. 2017 May; 56(2):426-437. Santi D, Granata AR, Pignatti E, Trenti T, Roli L, Bozic R, Zaza S, Pacchioni C, Rochira V, Carani C, Simoni M. PMID: 27515804.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    111. Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugates Provide Very Long-Acting Octreotide. Bioconjug Chem. 2016 07 20; 27(7):1638-44. Schneider EL, Henise J, Reid R, Ashley GW, Santi DV. PMID: 27253622.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    112. Treatment with human, recombinant FSH improves sperm DNA fragmentation in idiopathic infertile men depending on the FSH receptor polymorphism p.N680S: a pharmacogenetic study. Hum Reprod. 2016 09; 31(9):1960-9. Simoni M, Santi D, Negri L, Hoffmann I, Muratori M, Baldi E, Cambi M, Marcou M, Greither T, Baraldi E, Tagliavini S, Carra D, Lombardo F, Gandini L, Pallotti F, Krausz C, Rastrelli G, Ferlin A, Menegazzo M, Pignatti E, Linari F, Marino M, Benaglia R, Levi-Setti PE, Behre HM. PMID: 27329968.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCellsCTClinical Trials
    113. Sperm quality and environment: A retrospective, cohort study in a Northern province of Italy. Environ Res. 2016 10; 150:144-153. Santi D, Vezzani S, Granata AR, Roli L, De Santis MC, Ongaro C, Donati F, Baraldi E, Trenti T, Setti M, Simoni M. PMID: 27288912.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCellsPHPublic Health
    114. Surgical sealants with tunable swelling, burst pressures, and biodegradation rates. J Biomed Mater Res B Appl Biomater. 2017 08; 105(6):1602-1611. Henise J, Hearn BR, Santi DV, Kamata H, Sakai T, Ashley GW. PMID: 27149244.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    115. Hydrogel Drug Delivery System Using Self-Cleaving Covalent Linkers for Once-a-Week Administration of Exenatide. Bioconjug Chem. 2016 05 18; 27(5):1210-5. Schneider EL, Henise J, Reid R, Ashley GW, Santi DV. PMID: 26930186.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    116. Six months of daily treatment with vardenafil improves parameters of endothelial inflammation and of hypogonadism in male patients with type 2 diabetes and erectile dysfunction: a randomized, double-blind, prospective trial. Eur J Endocrinol. 2016 Apr; 174(4):513-22. Santi D, Granata AR, Guidi A, Pignatti E, Trenti T, Roli L, Bozic R, Zaza S, Pacchioni C, Romano S, Nofer JR, Rochira V, Carani C, Simoni M. PMID: 26792933.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    117. Impact of gene polymorphisms of gonadotropins and their receptors on human reproductive success. Reproduction. 2015 Dec; 150(6):R175-84. Casarini L, Santi D, Marino M. PMID: 26370242.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    118. High-Resolution Melting Is a Sensitive, Cost-Effective, Time-Saving Technique for BRAF V600E Detection in Thyroid FNAB Washing Liquid: A Prospective Cohort Study. Eur Thyroid J. 2015 Jun; 4(2):73-81. Marino M, Monzani ML, Brigante G, Cioni K, Madeo B, Santi D, Maiorana A, Bettelli S, Moriondo V, Pignatti E, Bonacini L, Carani C, Rochira V, Simoni M. PMID: 26279992; PMCID: PMC4521072.
      View in: PubMed   Mentions: 5  
    119. Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology. Eur J Pharm Biopharm. 2015 Jun; 93:254-9. Schneider EL, Ashley GW, Dillen L, Stoops B, Austin NE, Malcolm BA, Santi DV. PMID: 25900863.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    120. Erectile Dysfunction is Common among Men with Acromegaly and is Associated with Morbidities Related to the Disease. J Sex Med. 2015 May; 12(5):1184-93. Lotti F, Rochira V, Pivonello R, Santi D, Galdiero M, Maseroli E, Balestrieri A, Faustini-Fustini M, Peri A, Sforza A, Colao A, Maggi M, Corona G. PMID: 25736192.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    121. Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system. Bioconjug Chem. 2015 Feb 18; 26(2):270-8. Henise J, Hearn BR, Ashley GW, Santi DV. PMID: 25584814.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    122. Long-term stabilization of maleimide-thiol conjugates. Bioconjug Chem. 2015 Jan 21; 26(1):145-52. Fontaine SD, Reid R, Robinson L, Ashley GW, Santi DV. PMID: 25494821.
      View in: PubMed   Mentions: 91     Fields:    
    123. Therapy of endocrine disease. Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis. Eur J Endocrinol. 2015 Mar; 172(3):R103-14. Santi D, Giannetta E, Isidori AM, Vitale C, Aversa A, Simoni M. PMID: 25277671.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    124. The TRHR Gene Is Associated with Hypothalamo-Pituitary Sensitivity to Levothyroxine. Eur Thyroid J. 2014 Jun; 3(2):101-8. Brigante G, Spaggiari G, Santi D, Cioni K, Gnarini V, Diazzi C, Pignatti E, Casarini L, Marino M, Tüttelmann F, Carani C, Simoni M. PMID: 25114873; PMCID: PMC4109513.
      View in: PubMed   Mentions: 5  
    125. Biosimilar recombinant follicle stimulating hormones in infertility treatment. Expert Opin Biol Ther. 2014 Oct; 14(10):1399-409. Santi D, Simoni M. PMID: 24889801.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    126. Macromolecular prodrug that provides the irinotecan (CPT-11) active-metabolite SN-38 with ultralong half-life, low C(max), and low glucuronide formation. J Med Chem. 2014 Mar 27; 57(6):2303-14. Santi DV, Schneider EL, Ashley GW. PMID: 24494988.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    127. Male sexual dysfunction and HIV--a clinical perspective. Nat Rev Urol. 2014 Feb; 11(2):99-109. Santi D, Brigante G, Zona S, Guaraldi G, Rochira V. PMID: 24394405.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    128. β-Eliminative releasable linkers adapted for bioconjugation of macromolecules to phenols. Bioconjug Chem. 2013 Dec 18; 24(12):1990-7. Schneider EL, Robinson L, Reid R, Ashley GW, Santi DV. PMID: 24171387.
      View in: PubMed   Mentions: 2     Fields:    
    129. The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res. 2014 Feb; 42(3):2037-48. Czudnochowski N, Ashley GW, Santi DV, Alian A, Finer-Moore J, Stroud RM. PMID: 24214967; PMCID: PMC3919597.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    130. Hydrogel drug delivery system with predictable and tunable drug release and degradation rates. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2318-23. Ashley GW, Henise J, Reid R, Santi DV. PMID: 23345437; PMCID: PMC3568318.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    131. Erectile dysfunction is more common in young to middle-aged HIV-infected men than in HIV-uninfected men. J Sex Med. 2012 Jul; 9(7):1923-30. Zona S, Guaraldi G, Luzi K, Beggi M, Santi D, Stentarelli C, Madeo B, Rochira V. PMID: 22548701.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    132. Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6211-6. Santi DV, Schneider EL, Reid R, Robinson L, Ashley GW. PMID: 22474378; PMCID: PMC3341049.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    133. Premature decline of serum total testosterone in HIV-infected men in the HAART-era. PLoS One. 2011; 6(12):e28512. Rochira V, Zirilli L, Orlando G, Santi D, Brigante G, Diazzi C, Carli F, Carani C, Guaraldi G. PMID: 22174826; PMCID: PMC3235128.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    134. Using chemobiosynthesis and synthetic mini-polyketide synthases to produce pharmaceutical intermediates in Escherichia coli. Appl Environ Microbiol. 2010 Aug; 76(15):5221-7. Menzella HG, Carney JR, Li Y, Santi DV. PMID: 20543042; PMCID: PMC2916480.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    135. Synthesis of methyl halides from biomass using engineered microbes. J Am Chem Soc. 2009 May 13; 131(18):6508-15. Bayer TS, Widmaier DM, Temme K, Mirsky EA, Santi DV, Voigt CA. PMID: 19378995.
      View in: PubMed   Mentions: 89     Fields:    Translation:Cells
    136. Molecular modeling and crystal structure of ERK2-hypothemycin complexes. J Struct Biol. 2008 Oct; 164(1):18-23. Rastelli G, Rosenfeld R, Reid R, Santi DV. PMID: 18571434.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    137. Semisynthesis and cytotoxicity of hypothemycin analogues. ChemMedChem. 2007 Nov; 2(11):1598-600. Hearn BR, Sundermann K, Cannoy J, Santi DV. PMID: 17691074.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    138. Rational design and assembly of synthetic trimodular polyketide synthases. Chem Biol. 2007 Feb; 14(2):143-51. Menzella HG, Carney JR, Santi DV. PMID: 17317568.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    139. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20; 45(24):7415-28. Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM. PMID: 16768437; PMCID: PMC2556892.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    140. Activating hybrid modular interfaces in synthetic polyketide synthases by cassette replacement of ketosynthase domains. Chem Biol. 2006 May; 13(5):469-74. Chandran SS, Menzella HG, Carney JR, Santi DV. PMID: 16720267.
      View in: PubMed   Mentions: 12     Fields:    
    141. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4234-9. Schirmer A, Kennedy J, Murli S, Reid R, Santi DV. PMID: 16537514; PMCID: PMC1449676.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    142. Total synthesis of multi-kilobase DNA sequences from oligonucleotides. Nat Protoc. 2006; 1(6):2596-603. Reisinger SJ, Patel KG, Santi DV. PMID: 17406514.
      View in: PubMed   Mentions: 16     Fields:    
    143. Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster. J Ind Microbiol Biotechnol. 2006 Jan; 33(1):22-8. Menzella HG, Reisinger SJ, Welch M, Kealey JT, Kennedy J, Reid R, Tran CQ, Santi DV. PMID: 16187094.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    144. Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. Nat Biotechnol. 2005 Sep; 23(9):1171-6. Menzella HG, Reid R, Carney JR, Chandran SS, Reisinger SJ, Patel KG, Hopwood DA, Santi DV. PMID: 16116420.
      View in: PubMed   Mentions: 110     Fields:    Translation:Cells
    145. GeMS: an advanced software package for designing synthetic genes. Nucleic Acids Res. 2005; 33(9):3011-6. Jayaraj S, Reid R, Santi DV. PMID: 15911632; PMCID: PMC1137029.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    146. Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster. Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44):15573-8. Kodumal SJ, Patel KG, Reid R, Menzella HG, Welch M, Santi DV. PMID: 15496466; PMCID: PMC524854.
      View in: PubMed   Mentions: 79     Fields:    Translation:Cells
    147. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. Bioorg Med Chem. 2004 Oct 15; 12(20):5317-29. Tian ZQ, Liu Y, Zhang D, Wang Z, Dong SD, Carreras CW, Zhou Y, Rastelli G, Santi DV, Myles DC. PMID: 15388159.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    148. DNA ligation by selection. Biotechniques. 2004 Jul; 37(1):34, 36, 38 passim. Kodumal SJ, Santi DV. PMID: 15283197.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    149. A sensitive and robust method for quantification of intracellular short-chain coenzyme A esters. Anal Biochem. 2004 May 01; 328(1):51-9. Shimazu M, Vetcher L, Galazzo JL, Licari P, Santi DV. PMID: 15081907.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    150. The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase. Protein Eng. 2003 Aug; 16(8):607-14. Gonzalez-Pacanowska D, Ruiz-Perez LM, Carreras-Gómez MA, Costi MP, Stroud RM, Finer-Moore J, Santi DV. PMID: 12968078.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    151. Filter binding assay for the geldanamycin-heat shock protein 90 interaction. Anal Biochem. 2003 Jun 01; 317(1):40-6. Carreras CW, Schirmer A, Zhong Z, Santi DV. PMID: 12729599.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    152. Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. Chem Biol. 2003 Apr; 10(4):361-8. Jez JM, Chen JC, Rastelli G, Stroud RM, Santi DV. PMID: 12725864.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    153. Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. Biochemistry. 2003 Jan 21; 42(2):248-56. Finer-Moore JS, Santi DV, Stroud RM. PMID: 12525151.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    154. A model of structure and catalysis for ketoreductase domains in modular polyketide synthases. Biochemistry. 2003 Jan 14; 42(1):72-9. Reid R, Piagentini M, Rodriguez E, Ashley G, Viswanathan N, Carney J, Santi DV, Hutchinson CR, McDaniel R. PMID: 12515540.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    155. Stable expression of a synthetic gene for the human motilin receptor: use in an aequorin-based receptor activation assay. Anal Biochem. 2002 Jan 15; 300(2):146-51. Carreras CW, Siani MA, Santi DV, Dillon SB. PMID: 11779105.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    156. Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. J Biol Chem. 2002 Mar 15; 277(11):8835-40. Agarwalla S, Kealey JT, Santi DV, Stroud RM. PMID: 11779873.
      View in: PubMed   Mentions: 38     Fields:    Translation:Cells
    157. Order of substrate binding to tyrosyl-tRNA synthetase of Escherichia coli B. FEBS Lett. 1971 Mar 05; 13(3):157-160. Santi DV, Peña VA. PMID: 11945656.
      View in: PubMed   Mentions: 4     Fields:    
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