Daniel Santi, MD, PhD

Title(s)Professor Emeritus, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
AddressLocation Required
Varies CA 00000
Phone415-215-5586
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1980 Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Santi received a Ph.D. in Medicinal Chemistry from SUNY in 1967 and a M.D. from UCSF in 1981. He was Assistant Professor of Chemistry at UCSB from 1968 to 1974. He joined the UCSF faculty in 1974 and was Professor of Biochemistry and Biophysics, and of Pharmaceutical Chemistry at UCSF until 2000 when he became CEO of Kosan Biosciences. He returned to UCSF in 2007 where he served as interim Director of the UCSF CTSI and then Director of Translational Research at QB3. He became an Associate Dean of External Relationships in the School of Pharmacy in 2009, and manages an Industry Outreach Program. Dr. Santi has published over 300 scientific papers and is co-inventor on over 40 US patents.

    Santi was a member of the original Scientific Advisory Board of Chiron Corp. and has co-founded five biotechnology companies. In 1988, he founded and was Chairman of the peptide-combinatorial chemistry company Protos Corp., which merged with Chiron in 1992. He was also a co-founder of Parnassus Pharmaceuticals, and of Prospect Genomics which merged with Structural Genomix in 2001. In 1996, he co-founded Kosan Biosciences where he served as CEO and Chairman until 2006 when Kosan was acquired by Bristol Myers Squibb. He co-founded the platform technology company ProLynx LLC in 2010, where he currently serves as President.

    Collapse Research 
    Collapse Research Activities and Funding
    Combinatorial Biosynthesis of Polyketides
    NIH R44GM075639Sep 1, 2005 - Mar 5, 2006
    Role: Principal Investigator
    PROTEIN SEQUENCER AND DNA SEQUENCER
    NIH S10RR011422Jun 14, 1996 - Jun 13, 1997
    Role: Principal Investigator
    RNA Modification Enzymes: Methyltransferase/PSI-synthase
    NIH R01GM051232May 1, 1996 - May 31, 2013
    Role: Co-Principal Investigator
    ENZYME TARGETS OF OPPORTUNISTIC PATHOGENS IN AIDS
    NIH R01AI032784Sep 1, 1991 - May 31, 2000
    Role: Co-Principal Investigator
    DRUG TARGETS OF OPPORTUNISTIC PATHOGENS IN AIDS
    NIH U01AI030261Sep 30, 1990 - Nov 30, 1994
    Role: Principal Investigator
    DNA SYNTHESIZER AND ZYMARK ROBOTIC SYSTEM
    NIH S10RR005670Jun 6, 1990 - Jun 5, 1991
    Role: Principal Investigator
    AMINO ACID ANALYZER/HPLC/DNA SYNTHESIZER
    NIH S10RR003837Apr 4, 1988 - Apr 3, 1991
    Role: Principal Investigator
    AIDS RETROVIRUS REVERSE TRANSCRIPTASE
    NIH R01AI023972Aug 1, 1987 - Jul 31, 1990
    Role: Principal Investigator
    ENZYMES OF FOLATE METABOLISM IN PROTOZOA
    NIH R01AI019358Sep 1, 1982 - Apr 30, 1997
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    THYMIDYLATE SYNTHASE
    NIH R01CA014394Sep 1, 1978 - Feb 28, 2002
    Role: Co-Principal Investigator
    THYMIDYLATE SYNTHASE
    NIH R37CA014394Sep 1, 1978 - Feb 28, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Association of Nonalcoholic Fatty Liver Disease (NAFLD) with Peripheral Diabetic Polyneuropathy: A Systematic Review and Meta-Analysis. J Clin Med. 2021 Sep 28; 10(19). Greco C, Nascimbeni F, Carubbi F, Andreone P, Simoni M, Santi D. PMID: 34640482; PMCID: PMC8509344.
      View in: PubMed   Mentions:
    2. The Prevalence of Hypogonadism and the Effectiveness of Androgen Administration on Body Composition in HIV-Infected Men: A Meta-Analysis. Cells. 2021 Aug 12; 10(8). Santi D, Spaggiari G, Vena W, Pizzocaro A, Maggi M, Rochira V, Corona G. PMID: 34440836.
      View in: PubMed   Mentions:    Fields:    
    3. Does sacituzumab-govitecan act as a conventional antibody drug conjugate (ADC), a prodrug of SN-38 or both? Ann Transl Med. 2021 Jul; 9(14):1113. Santi DV, Cabel L, Bidard FC. PMID: 34430554.
      View in: PubMed   Mentions:
    4. Improvement of sperm morphology after surgical varicocele repair. Andrology. 2021 07; 9(4):1176-1184. Morini D, Spaggiari G, Daolio J, Melli B, Nicoli A, De Feo G, Valli B, Viola D, Garganigo S, Magnani E, Pilia A, Polese A, Colla R, Simoni M, Aguzzoli L, Villani MT, Santi D. PMID: 33825345.
      View in: PubMed   Mentions:    Fields:    
    5. Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles. Bioconjug Chem. 2021 04 21; 32(4):794-800. Hearn BR, Fontaine SD, Schneider EL, Kraemer Y, Ashley GW, Santi DV. PMID: 33822591.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males. Sci Rep. 2021 03 29; 11(1):7075. Brigante G, Spaggiari G, Rossi B, Granata A, Simoni M, Santi D. PMID: 33782499.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    7. Psychotropic Drugs Levels in Seminal Fluid: A New Therapeutic Drug Monitoring Analysis? Front Endocrinol (Lausanne). 2021; 12:620936. Mazzilli R, Curto M, De Bernardini D, Olana S, Capi M, Salerno G, Cipolla F, Zamponi V, Santi D, Mazzilli F, Simmaco M, Lionetto L. PMID: 33776918.
      View in: PubMed   Mentions:
    8. HIV and Sexual Dysfunction in Men. J Clin Med. 2021 Mar 05; 10(5). De Vincentis S, Tartaro G, Rochira V, Santi D. PMID: 33807833.
      View in: PubMed   Mentions:
    9. The "Hitchhiker's Guide to the Galaxy" of Endothelial Dysfunction Markers in Human Fertility. Int J Mol Sci. 2021 Mar 04; 22(5). Santi D, Spaggiari G, Greco C, Lazzaretti C, Paradiso E, Casarini L, Potì F, Brigante G, Simoni M. PMID: 33806677.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    10. Spontaneous pregnancies among infertile couples during assisted reproduction lockdown for COVID-19 pandemic. Andrology. 2021 07; 9(4):1038-1041. Villani MT, Morini D, Spaggiari G, Simoni M, Aguzzoli L, Santi D. PMID: 33427417.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    11. Gynecological malignancy mimicking a thyroid lymph node metastasis. Endocrinol Diabetes Metab Case Rep. 2021 Jan 11; 2021. Pederzoli S, Spaggiari G, Bernardelli G, Mattioli F, Baldessari C, Maiorana A, Rochira V, Santi D. PMID: 33431707.
      View in: PubMed   Mentions:
    12. Health status is related to testosterone, estrone and body fat: moving to functional hypogonadism in adult men with HIV. Eur J Endocrinol. 2021 Jan; 184(1):107-122. De Vincentis S, Decaroli MC, Fanelli F, Diazzi C, Mezzullo M, Morini F, Bertani D, Milic J, Carli F, Cuomo G, Santi D, Tartaro G, Tagliavini S, De Santis MC, Roli L, Trenti T, Pagotto U, Guaraldi G, Rochira V. PMID: 33112262.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. A Very Long-Acting PARP Inhibitor Suppresses Cancer Cell Growth in DNA Repair-Deficient Tumor Models. Cancer Res. 2021 02 15; 81(4):1076-1086. Fontaine SD, Ashley GW, Houghton PJ, Kurmasheva RT, Diolaiti M, Ashworth A, Peer CJ, Nguyen R, Figg WD, Beckford-Vera DR, Santi DV. PMID: 33323380.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. Elevated levels of nitrous dioxide are associated with lower AMH levels: a real-world analysis. Hum Reprod. 2020 11 01; 35(11):2589-2597. La Marca A, Spaggiari G, Domenici D, Grassi R, Casonati A, Baraldi E, Trenti T, Simoni M, Santi D. PMID: 32951044.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    15. Eating Behavior after Bariatric Surgery (EBBS) Questionnaire: a New Validated Tool to Quantify the Patients' Compliance to Post-Bariatric Dietary and Lifestyle Suggestions. Obes Surg. 2020 Oct; 30(10):3831-3838. Spaggiari G, Santi D, Budriesi G, Dondi P, Cavedoni S, Leonardi L, Delvecchio C, Valentini L, Bondi M, Miloro C, Toschi PF. PMID: 32447636.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Interleukin 15 Pharmacokinetics and Consumption by a Dynamic Cytokine Sink. Front Immunol. 2020; 11:1813. Hangasky JA, Waldmann TA, Santi DV. PMID: 32903632.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    17. Effects of acute hCG stimulation on serum INSL3 and 25-OH vitamin D in Klinefelter syndrome. Andrology. 2020 11; 8(6):1720-1727. Santi D, Ivell R, Anand-Ivell R, De Toni L, Fanelli F, Mezzullo M, Pelusi C, Pagotto U, Belli S, Granata ARM, Roli L, Rochira V, Trenti T, Ferlin A, Simoni M. PMID: 32593193.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    18. Prospects for FSH Treatment of Male Infertility. J Clin Endocrinol Metab. 2020 07 01; 105(7). Simoni M, Brigante G, Rochira V, Santi D, Casarini L. PMID: 32374828.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. Multilevel approach to male fertility by machine learning highlights a hidden link between haematological and spermatogenetic cells. Andrology. 2020 09; 8(5):1021-1029. Santi D, Spaggiari G, Casonati A, Casarini L, Grassi R, Vecchi B, Roli L, De Santis MC, Orlando G, Gravotta E, Baraldi E, Setti M, Trenti T, Simoni M. PMID: 32449608.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. To beer or not to beer: A meta-analysis of the effects of beer consumption on cardiovascular health. PLoS One. 2020; 15(6):e0233619. Spaggiari G, Cignarelli A, Sansone A, Baldi M, Santi D. PMID: 32492025.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation. Asian J Androl. 2020 May-Jun; 22(3):302-308. Spaggiari G, M Granata AR, Santi D. PMID: 31274478.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Follicle-stimulating Hormone (FSH) Action on Spermatogenesis: A Focus on Physiological and Therapeutic Roles. J Clin Med. 2020 Apr 03; 9(4). Santi D, Crépieux P, Reiter E, Spaggiari G, Brigante G, Casarini L, Rochira V, Simoni M. PMID: 32260182.
      View in: PubMed   Mentions:
    23. FSH for the Treatment of Male Infertility. Int J Mol Sci. 2020 Mar 25; 21(7). Casarini L, Crépieux P, Reiter E, Lazzaretti C, Paradiso E, Rochira V, Brigante G, Santi D, Simoni M. PMID: 32218314.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    24. The physician's gender influences the results of the diagnostic workup for erectile dysfunction. Andrology. 2020 05; 8(3):671-679. Rastrelli G, Cipriani S, Craparo A, De Vincentis S, Granata ARM, Spaggiari G, Simoni M, Maggi M, Santi D. PMID: 31955507.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Prospective use of the single-mouse experimental design for the evaluation of PLX038A. Cancer Chemother Pharmacol. 2020 02; 85(2):251-263. Ghilu S, Li Q, Fontaine SD, Santi DV, Kurmasheva RT, Zheng S, Houghton PJ. PMID: 31927611.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Seasonal Changes of Serum Gonadotropins and Testosterone in Men Revealed by a Large Data Set of Real-World Observations Over Nine Years. Front Endocrinol (Lausanne). 2019; 10:914. Santi D, Spaggiari G, Granata ARM, Setti M, Tagliavini S, Trenti T, Simoni M. PMID: 31998242.
      View in: PubMed   Mentions:
    27. FSH treatment of male idiopathic infertility: Time for a paradigm change. Andrology. 2020 05; 8(3):535-544. Simoni M, Santi D. PMID: 31872552.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    28. Use of follicle-stimulating hormone for the male partner of idiopathic infertile couples in Italy: Results from a multicentre, observational, clinical practice survey. Andrology. 2020 05; 8(3):637-644. Santi D, De Vincentis S, Alfano P, Balercia G, Calogero AE, Cargnelutti F, Coccia ME, Condorelli RA, Dal Lago A, de Angelis C, Gallo M, Iannantuoni N, Lombardo F, Marino A, Mazzella M, Pallotti F, Paoli D, Pivonello R, Rago R, Rampini M, Salvio G, Simoni M. PMID: 31872967.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men. Andrology. 2020 01; 8(1):53-81. Esteves SC, Santi D, Simoni M. PMID: 31692293.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    30. PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89. Mol Cancer Ther. 2020 02; 19(2):673-679. Beckford Vera DR, Fontaine SD, VanBrocklin HF, Hearn BR, Reid R, Ashley GW, Santi DV. PMID: 31744896.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    31. PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity. Cancer Chemother Pharmacol. 2020 01; 85(1):225-229. Fontaine SD, Santi AD, Reid R, Smith PC, Ashley GW, Santi DV. PMID: 31707444.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    32. Editorial: Follicle-Stimulating Hormone: Fertility and Beyond. Front Endocrinol (Lausanne). 2019; 10:610. Simoni M, Huhtaniemi I, Santi D, Casarini L. PMID: 31551936.
      View in: PubMed   Mentions:
    33. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study. Endocr Connect. 2019 Aug 01; 8(8):1118-1125. Melcangi RC, Casarini L, Marino M, Santi D, Sperduti S, Giatti S, Diviccaro S, Grimoldi M, Caruso D, Cavaletti G, Simoni M. PMID: 31272082.
      View in: PubMed   Mentions:
    34. Semi-annual seasonal pattern of serum thyrotropin in adults. Sci Rep. 2019 07 25; 9(1):10786. Santi D, Spaggiari G, Brigante G, Setti M, Tagliavini S, Trenti T, Simoni M. PMID: 31346248.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    35. Species-specific optimization of PEG~SN-38 prodrug pharmacokinetics and antitumor effects in a triple-negative BRCA1-deficient xenograft. Cancer Chemother Pharmacol. 2019 10; 84(4):729-738. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Fontaine SD, Hann B, Reid R, Ashley GW, Santi DV. PMID: 31321449.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    36. Effect of treatment with testosterone on endothelial function in hypogonadal men: a systematic review and meta-analysis. Int J Impot Res. 2020 Jul; 32(4):379-386. Sansone A, Rastrelli G, Cignarelli A, de Rocco Ponce M, Condorelli RA, Giannetta E, Maseroli E, Pinto S, Salzano C, Santi D. PMID: 31235898.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. An Observational Retrospective Cohort Trial on 4,828 IVF Cycles Evaluating Different Low Prognosis Patients Following the POSEIDON Criteria. Front Endocrinol (Lausanne). 2019; 10:282. Levi-Setti PE, Zerbetto I, Baggiani A, Zannoni E, Sacchi L, Smeraldi A, Morenghi E, De Cesare R, Drovanti A, Santi D. PMID: 31139146.
      View in: PubMed   Mentions:
    38. Expression and clinicopathological role of miR146a in thyroid follicular carcinoma. Endocrine. 2019 06; 64(3):575-583. Pignatti E, Vighi E, Magnani E, Kara E, Roncati L, Maiorana A, Santi D, Madeo B, Cioni K, Carani C, Rochira V, Simoni M, Brigante G. PMID: 30701447.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Relative hyperestrogenism in Klinefelter Syndrome: results from a meta-analysis. Endocrine. 2019 05; 64(2):209-219. Santi D, De Vincentis S, Scaltriti S, Rochira V. PMID: 30701446.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis. Int J Mol Sci. 2019 Jan 16; 20(2). Potì F, Santi D, Spaggiari G, Zimetti F, Zanotti I. PMID: 30654461.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    41. Two Hormones for One Receptor: Evolution, Biochemistry, Actions, and Pathophysiology of LH and hCG. Endocr Rev. 2018 10 01; 39(5):549-592. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Casarini L, Santi D, Brigante G, Simoni M. PMID: 29905829.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    42. Clinical relevance of genetic variants of gonadotrophins and their receptors in controlled ovarian stimulation: a systematic review and meta-analysis. Hum Reprod Update. 2018 09 01; 24(5):599-614. Alviggi C, Conforti A, Santi D, Esteves SC, Andersen CY, Humaidan P, Chiodini P, De Placido G, Simoni M. PMID: 29924306.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    43. A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules. Transl Vis Sci Technol. 2018 Jul; 7(4):21. Machinaga N, Ashley GW, Reid R, Yamasaki A, Tanaka K, Nakamura K, Yabe Y, Yoshigae Y, Santi DV. PMID: 30174998.
      View in: PubMed   Mentions:
    44. Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management - meta-analyses. Reprod Biomed Online. 2018 09; 37(3):315-326. Santi D, Spaggiari G, Simoni M. PMID: 30314886.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    45. Could chronic Vardenafil administration influence the cardiovascular risk in men with type 2 diabetes mellitus? PLoS One. 2018; 13(6):e0199299. Santi D, Locaso M, Granata AR, Trenti T, Roli L, Pacchioni C, Rochira V, Carani C, Simoni M. PMID: 29953477.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    46. AN ITALIAN SURVEY OF COMPLIANCE WITH MAJOR GUIDELINES FOR L-THYROXINE OF PRIMARY HYPOTHYROIDISM. Endocr Pract. 2018 May; 24(5):419-428. Vezzani S, Giannetta E, Altieri B, Barbonetti A, Bellastella G, Certo R, Cignarelli A, Cinti F, D'Andrea S, Di Dalmazi G, Frara S, Garelli S, Giuffrida G, Maiorino MI, Mele C, Mezza T, Pani MG, Samà MT, Satta C, Santi D. PMID: 29847168.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    47. Response: Commentary: Efficacy of Follicle-Stimulating Hormone (FSH) Alone, FSH + Luteinizing Hormone, Human Menopausal Gonadotropin or FSH + Human Chorionic Gonadotropin on Assisted Reproductive Technology Outcomes in the "Personalized" Medicine Era: A Meta-analysis. Front Endocrinol (Lausanne). 2018; 9:113. Santi D, Casarini L, Alviggi C, Simoni M. PMID: 29628912.
      View in: PubMed   Mentions:
    48. Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system. J Control Release. 2018 05 28; 278:74-79. Hearn BR, Fontaine SD, Pfaff SJ, Schneider EL, Henise J, Ashley GW, Santi DV. PMID: 29577950.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Seasonal variation of semen parameters correlates with environmental temperature and air pollution: A big data analysis over 6 years. Environ Pollut. 2018 Apr; 235:806-813. Santi D, Magnani E, Michelangeli M, Grassi R, Vecchi B, Pedroni G, Roli L, De Santis MC, Baraldi E, Setti M, Trenti T, Simoni M. PMID: 29353799.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    50. 'Spare' Luteinizing Hormone Receptors: Facts and Fiction. Trends Endocrinol Metab. 2018 04; 29(4):208-217. Casarini L, Santi D, Simoni M, Potì F. PMID: 29429918.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    51. Pharmacogenetics of G-protein-coupled receptors variants: FSH receptor and infertility treatment. Best Pract Res Clin Endocrinol Metab. 2018 04; 32(2):189-200. Santi D, Potì F, Simoni M, Casarini L. PMID: 29678285.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    52. Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment. Front Endocrinol (Lausanne). 2017; 8:316. Spaggiari G, Brigante G, De Vincentis S, Cattini U, Roli L, De Santis MC, Baraldi E, Tagliavini S, Varani M, Trenti T, Rochira V, Simoni M, Santi D. PMID: 29184537.
      View in: PubMed   Mentions:
    53. Serum Calcium to Phosphorous (Ca/P) Ratio Is a Simple, Inexpensive, and Accurate Tool in the Diagnosis of Primary Hyperparathyroidism. JBMR Plus. 2018 Mar; 2(2):109-117. Madeo B, Kara E, Cioni K, Vezzani S, Trenti T, Santi D, Simoni M, Rochira V. PMID: 30283895.
      View in: PubMed   Mentions:
    54. Gene Expression and Apoptosis Levels in Cumulus Cells of Patients with Polymorphisms of FSHR and LHB Undergoing in Vitro Fertilization Program. Cell Physiol Biochem. 2017; 43(6):2391-2404. Bosco L, Ruvolo G, Luparello C, Ferrari S, Valerio D, Santi D, Piomboni P, Sarcina E, Lispi M, Roccheri MC. PMID: 29073627.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    55. Molecular basis of androgen action on human sexual desire. Mol Cell Endocrinol. 2018 05 15; 467:31-41. Santi D, Spaggiari G, Gilioli L, Potì F, Simoni M, Casarini L. PMID: 28893567.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    56. A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP-1 Receptor Agonist. ACS Chem Biol. 2017 08 18; 12(8):2107-2116. Schneider EL, Hearn BR, Pfaff SJ, Reid R, Parkes DG, Vrang N, Ashley GW, Santi DV. PMID: 28605180.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    57. Advances in Robotic Transaxillary Thyroidectomy in Europe. Curr Surg Rep. 2017; 5(8):17. Piccoli M, Mullineris B, Santi D, Gozzo D. PMID: 28680769.
      View in: PubMed   Mentions:
    58. Efficacy of Follicle-Stimulating Hormone (FSH) Alone, FSH + Luteinizing Hormone, Human Menopausal Gonadotropin or FSH + Human Chorionic Gonadotropin on Assisted Reproductive Technology Outcomes in the "Personalized" Medicine Era: A Meta-analysis. Front Endocrinol (Lausanne). 2017; 8:114. Santi D, Casarini L, Alviggi C, Simoni M. PMID: 28620352.
      View in: PubMed   Mentions:
    59. Genetics of gonadotropins and their receptors as markers of ovarian reserve and response in controlled ovarian stimulation. Best Pract Res Clin Obstet Gynaecol. 2017 Oct; 44:15-25. Riccetti L, De Pascali F, Gilioli L, Santi D, Brigante G, Simoni M, Casarini L. PMID: 28506471.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    60. Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients. J Steroid Biochem Mol Biol. 2017 07; 171:229-235. Melcangi RC, Santi D, Spezzano R, Grimoldi M, Tabacchi T, Fusco ML, Diviccaro S, Giatti S, Carrà G, Caruso D, Simoni M, Cavaletti G. PMID: 28408350.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    61. Central hypogonadism due to a giant, "silent" FSH-secreting, atypical pituitary adenoma: effects of adenoma dissection and short-term Leydig cell stimulation by luteinizing hormone (LH) and human chorionic gonadotropin (hCG). Aging Male. 2017 Jun; 20(2):96-101. Santi D, Spaggiari G, Casarini L, Fanelli F, Mezzullo M, Pagotto U, Granata ARM, Carani C, Simoni M. PMID: 28067604.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    62. Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake. Bioconjug Chem. 2016 Oct 19; 27(10):2534-2539. Schneider EL, Hearn BR, Pfaff SJ, Fontaine SD, Reid R, Ashley GW, Grabulovski S, Strassberger V, Vogt L, Jung T, Santi DV. PMID: 27657443.
      View in: PubMed   Mentions: 2     Fields:    
    63. Effects of chronic administration of the phosphodiesterase inhibitor vardenafil on serum levels of adrenal and testicular steroids in men with type 2 diabetes mellitus. Endocrine. 2017 May; 56(2):426-437. Santi D, Granata AR, Pignatti E, Trenti T, Roli L, Bozic R, Zaza S, Pacchioni C, Rochira V, Carani C, Simoni M. PMID: 27515804.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    64. Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugates Provide Very Long-Acting Octreotide. Bioconjug Chem. 2016 07 20; 27(7):1638-44. Schneider EL, Henise J, Reid R, Ashley GW, Santi DV. PMID: 27253622.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    65. Treatment with human, recombinant FSH improves sperm DNA fragmentation in idiopathic infertile men depending on the FSH receptor polymorphism p.N680S: a pharmacogenetic study. Hum Reprod. 2016 09; 31(9):1960-9. Simoni M, Santi D, Negri L, Hoffmann I, Muratori M, Baldi E, Cambi M, Marcou M, Greither T, Baraldi E, Tagliavini S, Carra D, Lombardo F, Gandini L, Pallotti F, Krausz C, Rastrelli G, Ferlin A, Menegazzo M, Pignatti E, Linari F, Marino M, Benaglia R, Levi-Setti PE, Behre HM. PMID: 27329968.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsCTClinical Trials
    66. Sperm quality and environment: A retrospective, cohort study in a Northern province of Italy. Environ Res. 2016 10; 150:144-153. Santi D, Vezzani S, Granata AR, Roli L, De Santis MC, Ongaro C, Donati F, Baraldi E, Trenti T, Setti M, Simoni M. PMID: 27288912.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsPHPublic Health
    67. Surgical sealants with tunable swelling, burst pressures, and biodegradation rates. . 2017 08; 105(6):1602-1611. Henise J, Hearn BR, Santi DV, Kamata H, Sakai T, Ashley GW. PMID: 27149244.
      View in: PubMed   Mentions:
    68. Hydrogel Drug Delivery System Using Self-Cleaving Covalent Linkers for Once-a-Week Administration of Exenatide. Bioconjug Chem. 2016 05 18; 27(5):1210-5. Schneider EL, Henise J, Reid R, Ashley GW, Santi DV. PMID: 26930186.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    69. Six months of daily treatment with vardenafil improves parameters of endothelial inflammation and of hypogonadism in male patients with type 2 diabetes and erectile dysfunction: a randomized, double-blind, prospective trial. Eur J Endocrinol. 2016 Apr; 174(4):513-22. Santi D, Granata AR, Guidi A, Pignatti E, Trenti T, Roli L, Bozic R, Zaza S, Pacchioni C, Romano S, Nofer JR, Rochira V, Carani C, Simoni M. PMID: 26792933.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    70. Impact of gene polymorphisms of gonadotropins and their receptors on human reproductive success. Reproduction. 2015 Dec; 150(6):R175-84. Casarini L, Santi D, Marino M. PMID: 26370242.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    71. High-Resolution Melting Is a Sensitive, Cost-Effective, Time-Saving Technique for BRAF V600E Detection in Thyroid FNAB Washing Liquid: A Prospective Cohort Study. Eur Thyroid J. 2015 Jun; 4(2):73-81. Marino M, Monzani ML, Brigante G, Cioni K, Madeo B, Santi D, Maiorana A, Bettelli S, Moriondo V, Pignatti E, Bonacini L, Carani C, Rochira V, Simoni M. PMID: 26279992.
      View in: PubMed   Mentions:
    72. Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology. Eur J Pharm Biopharm. 2015 Jun; 93:254-9. Schneider EL, Ashley GW, Dillen L, Stoops B, Austin NE, Malcolm BA, Santi DV. PMID: 25900863.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    73. Erectile Dysfunction is Common among Men with Acromegaly and is Associated with Morbidities Related to the Disease. J Sex Med. 2015 May; 12(5):1184-93. Lotti F, Rochira V, Pivonello R, Santi D, Galdiero M, Maseroli E, Balestrieri A, Faustini-Fustini M, Peri A, Sforza A, Colao A, Maggi M, Corona G. PMID: 25736192.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    74. Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system. Bioconjug Chem. 2015 Feb 18; 26(2):270-8. Henise J, Hearn BR, Ashley GW, Santi DV. PMID: 25584814.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    75. Long-term stabilization of maleimide-thiol conjugates. Bioconjug Chem. 2015 Jan 21; 26(1):145-52. Fontaine SD, Reid R, Robinson L, Ashley GW, Santi DV. PMID: 25494821.
      View in: PubMed   Mentions: 46     Fields:    
    76. Therapy of endocrine disease. Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis. Eur J Endocrinol. 2015 Mar; 172(3):R103-14. Santi D, Giannetta E, Isidori AM, Vitale C, Aversa A, Simoni M. PMID: 25277671.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    77. The TRHR Gene Is Associated with Hypothalamo-Pituitary Sensitivity to Levothyroxine. Eur Thyroid J. 2014 Jun; 3(2):101-8. Brigante G, Spaggiari G, Santi D, Cioni K, Gnarini V, Diazzi C, Pignatti E, Casarini L, Marino M, Tüttelmann F, Carani C, Simoni M. PMID: 25114873.
      View in: PubMed   Mentions:
    78. Biosimilar recombinant follicle stimulating hormones in infertility treatment. Expert Opin Biol Ther. 2014 Oct; 14(10):1399-409. Santi D, Simoni M. PMID: 24889801.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    79. Macromolecular prodrug that provides the irinotecan (CPT-11) active-metabolite SN-38 with ultralong half-life, low C(max), and low glucuronide formation. J Med Chem. 2014 Mar 27; 57(6):2303-14. Santi DV, Schneider EL, Ashley GW. PMID: 24494988.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    80. Male sexual dysfunction and HIV--a clinical perspective. Nat Rev Urol. 2014 Feb; 11(2):99-109. Santi D, Brigante G, Zona S, Guaraldi G, Rochira V. PMID: 24394405.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    81. β-Eliminative releasable linkers adapted for bioconjugation of macromolecules to phenols. Bioconjug Chem. 2013 Dec 18; 24(12):1990-7. Schneider EL, Robinson L, Reid R, Ashley GW, Santi DV. PMID: 24171387.
      View in: PubMed   Mentions:    Fields:    
    82. The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res. 2014 Feb; 42(3):2037-48. Czudnochowski N, Ashley GW, Santi DV, Alian A, Finer-Moore J, Stroud RM. PMID: 24214967.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    83. Hydrogel drug delivery system with predictable and tunable drug release and degradation rates. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2318-23. Ashley GW, Henise J, Reid R, Santi DV. PMID: 23345437.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    84. Erectile dysfunction is more common in young to middle-aged HIV-infected men than in HIV-uninfected men. J Sex Med. 2012 Jul; 9(7):1923-30. Zona S, Guaraldi G, Luzi K, Beggi M, Santi D, Stentarelli C, Madeo B, Rochira V. PMID: 22548701.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    85. Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6211-6. Santi DV, Schneider EL, Reid R, Robinson L, Ashley GW. PMID: 22474378.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    86. Premature decline of serum total testosterone in HIV-infected men in the HAART-era. PLoS One. 2011; 6(12):e28512. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Rochira V, Zirilli L, Orlando G, Santi D, Brigante G, Diazzi C, Carli F, Carani C, Guaraldi G. PMID: 22174826; PMCID: PMC3235128.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    87. Synthesis of methyl halides from biomass using engineered microbes. J Am Chem Soc. 2009 May 13; 131(18):6508-15. Bayer TS, Widmaier DM, Temme K, Mirsky EA, Santi DV, Voigt CA. PMID: 19378995.
      View in: PubMed   Mentions: 75     Fields:    Translation:Cells
    88. Molecular modeling and crystal structure of ERK2-hypothemycin complexes. J Struct Biol. 2008 Oct; 164(1):18-23. Rastelli G, Rosenfeld R, Reid R, Santi DV. PMID: 18571434.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    89. Semisynthesis and cytotoxicity of hypothemycin analogues. ChemMedChem. 2007 Nov; 2(11):1598-600. Hearn BR, Sundermann K, Cannoy J, Santi DV. PMID: 17691074.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    90. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20; 45(24):7415-28. Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM. PMID: 16768437.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    91. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4234-9. Schirmer A, Kennedy J, Murli S, Reid R, Santi DV. PMID: 16537514.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    92. Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster. J Ind Microbiol Biotechnol. 2006 Jan; 33(1):22-8. Menzella HG, Reisinger SJ, Welch M, Kealey JT, Kennedy J, Reid R, Tran CQ, Santi DV. PMID: 16187094.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    93. Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. Nat Biotechnol. 2005 Sep; 23(9):1171-6. Menzella HG, Reid R, Carney JR, Chandran SS, Reisinger SJ, Patel KG, Hopwood DA, Santi DV. PMID: 16116420.
      View in: PubMed   Mentions: 95     Fields:    Translation:Cells
    94. GeMS: an advanced software package for designing synthetic genes. Nucleic Acids Res. 2005; 33(9):3011-6. Jayaraj S, Reid R, Santi DV. PMID: 15911632.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    95. Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster. Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44):15573-8. Kodumal SJ, Patel KG, Reid R, Menzella HG, Welch M, Santi DV. PMID: 15496466.
      View in: PubMed   Mentions: 74     Fields:    Translation:Cells
    96. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. Bioorg Med Chem. 2004 Oct 15; 12(20):5317-29. Tian ZQ, Liu Y, Zhang D, Wang Z, Dong SD, Carreras CW, Zhou Y, Rastelli G, Santi DV, Myles DC. PMID: 15388159.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    97. The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase. Protein Eng. 2003 Aug; 16(8):607-14. Gonzalez-Pacanowska D, Ruiz-Perez LM, Carreras-Gómez MA, Costi MP, Stroud RM, Finer-Moore J, Santi DV. PMID: 12968078.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    98. Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. Chem Biol. 2003 Apr; 10(4):361-8. Jez JM, Chen JC, Rastelli G, Stroud RM, Santi DV. PMID: 12725864.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    99. Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. Biochemistry. 2003 Jan 21; 42(2):248-56. Finer-Moore JS, Santi DV, Stroud RM. PMID: 12525151.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    100. A model of structure and catalysis for ketoreductase domains in modular polyketide synthases. Biochemistry. 2003 Jan 14; 42(1):72-9. Reid R, Piagentini M, Rodriguez E, Ashley G, Viswanathan N, Carney J, Santi DV, Hutchinson CR, McDaniel R. PMID: 12515540.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    101. Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry. 2002 Apr 23; 41(16):5193-201. Dayem LC, Carney JR, Santi DV, Pfeifer BA, Khosla C, Kealey JT. PMID: 11955068.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    102. Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. J Biol Chem. 2002 Mar 15; 277(11):8835-40. Agarwalla S, Kealey JT, Santi DV, Stroud RM. PMID: 11779873.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
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