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Daniel Santi, MD, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
AddressLocation Required
Varies CA 00000
Phone415-215-5586
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoM.D.1980 Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Santi received a Ph.D. in Medicinal Chemistry from SUNY in 1967 and a M.D. from UCSF in 1981. He was Assistant Professor of Chemistry at UCSB from 1968 to 1974. He joined the UCSF faculty in 1974 and was Professor of Biochemistry and Biophysics, and of Pharmaceutical Chemistry at UCSF until 2000 when he became CEO of Kosan Biosciences. He returned to UCSF in 2007 where he served as interim Director of the UCSF CTSI and then Director of Translational Research at QB3. He became an Associate Dean of External Relationships in the School of Pharmacy in 2009, and manages an Industry Outreach Program. Dr. Santi has published over 300 scientific papers and is co-inventor on over 40 US patents.

    Santi was a member of the original Scientific Advisory Board of Chiron Corp. and has co-founded five biotechnology companies. In 1988, he founded and was Chairman of the peptide-combinatorial chemistry company Protos Corp., which merged with Chiron in 1992. He was also a co-founder of Parnassus Pharmaceuticals, and of Prospect Genomics which merged with Structural Genomix in 2001. In 1996, he co-founded Kosan Biosciences where he served as CEO and Chairman until 2006 when Kosan was acquired by Bristol Myers Squibb. He co-founded the platform technology company ProLynx LLC in 2010, where he currently serves as President.

    Collapse Research 
    Collapse Research Activities and Funding
    Combinatorial Biosynthesis of Polyketides
    NIH R44GM075639Sep 1, 2005 - Mar 5, 2006
    Role: Principal Investigator
    PROTEIN SEQUENCER AND DNA SEQUENCER
    NIH S10RR011422Jun 14, 1996 - Jun 13, 1997
    Role: Principal Investigator
    RNA Modification Enzymes: Methyltransferase/PSI-synthase
    NIH R01GM051232May 1, 1996 - May 31, 2013
    Role: Co-Principal Investigator
    ENZYME TARGETS OF OPPORTUNISTIC PATHOGENS IN AIDS
    NIH R01AI032784Sep 1, 1991 - May 31, 2000
    Role: Co-Principal Investigator
    DRUG TARGETS OF OPPORTUNISTIC PATHOGENS IN AIDS
    NIH U01AI030261Sep 30, 1990 - Nov 30, 1994
    Role: Principal Investigator
    DNA SYNTHESIZER AND ZYMARK ROBOTIC SYSTEM
    NIH S10RR005670Jun 6, 1990 - Jun 5, 1991
    Role: Principal Investigator
    AMINO ACID ANALYZER/HPLC/DNA SYNTHESIZER
    NIH S10RR003837Apr 4, 1988 - Apr 3, 1991
    Role: Principal Investigator
    AIDS RETROVIRUS REVERSE TRANSCRIPTASE
    NIH R01AI023972Aug 1, 1987 - Jul 31, 1990
    Role: Principal Investigator
    ENZYMES OF FOLATE METABOLISM IN PROTOZOA
    NIH R01AI019358Sep 1, 1982 - Apr 30, 1997
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    THYMIDYLATE SYNTHASE
    NIH R01CA014394Sep 1, 1978 - Feb 28, 2002
    Role: Co-Principal Investigator
    THYMIDYLATE SYNTHASE
    NIH R37CA014394Sep 1, 1978 - Feb 28, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Improvement of sperm morphology after surgical varicocele repair. Andrology. 2021 Apr 07. PMID: 33825345.
      View in: PubMed   Mentions:    Fields:    
    2. Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles. Bioconjug Chem. 2021 Apr 06. PMID: 33822591.
      View in: PubMed   Mentions:    Fields:    
    3. A prospective, observational clinical trial on the impact of COVID-19-related national lockdown on thyroid hormone in young males. Sci Rep. 2021 03 29; 11(1):7075. PMID: 33782499.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    4. Psychotropic Drugs Levels in Seminal Fluid: A New Therapeutic Drug Monitoring Analysis? Front Endocrinol (Lausanne). 2021; 12:620936. PMID: 33776918.
      View in: PubMed   Mentions:
    5. HIV and Sexual Dysfunction in Men. J Clin Med. 2021 Mar 05; 10(5). PMID: 33807833.
      View in: PubMed   Mentions:
    6. The "Hitchhiker's Guide to the Galaxy" of Endothelial Dysfunction Markers in Human Fertility. Int J Mol Sci. 2021 Mar 04; 22(5). PMID: 33806677.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Gynecological malignancy mimicking a thyroid lymph node metastasis. Endocrinol Diabetes Metab Case Rep. 2021 Jan 11; 2021. Pederzoli S, Spaggiari G, Bernardelli G, Mattioli F, Baldessari C, Maiorana A, Rochira V, Santi D. PMID: 33431707.
      View in: PubMed   Mentions:
    8. Spontaneous pregnancies among infertile couples during assisted reproduction lockdown for COVID-19 pandemic. Andrology. 2021 Jan 11. Villani MT, Morini D, Spaggiari G, Simoni M, Aguzzoli L, Santi D. PMID: 33427417.
      View in: PubMed   Mentions:    Fields:    
    9. Health status is related to testosterone, estrone and body fat: moving to functional hypogonadism in adult men with HIV. Eur J Endocrinol. 2021 Jan; 184(1):107-122. De Vincentis S, Decaroli MC, Fanelli F, Diazzi C, Mezzullo M, Morini F, Bertani D, Milic J, Carli F, Cuomo G, Santi D, Tartaro G, Tagliavini S, De Santis MC, Roli L, Trenti T, Pagotto U, Guaraldi G, Rochira V. PMID: 33112262.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. A very long-acting Poly(ADP-ribose) polymerase inhibitor suppresses cancer cell growth in DNA repair-deficient tumor models. Cancer Res. 2020 Dec 15. Fontaine SD, Ashley GW, Houghton PJ, Kurmasheva RT, Diolaiti M, Ashworth A, Peer CJ, Nguyen R, Figg WD, Beckford-Vera DR, Santi DV. PMID: 33323380.
      View in: PubMed   Mentions:    Fields:    
    11. Elevated levels of nitrous dioxide are associated with lower AMH levels: a real-world analysis. Hum Reprod. 2020 Nov 01; 35(11):2589-2597. La Marca A, Spaggiari G, Domenici D, Grassi R, Casonati A, Baraldi E, Trenti T, Simoni M, Santi D. PMID: 32951044.
      View in: PubMed   Mentions:    Fields:    
    12. Eating Behavior after Bariatric Surgery (EBBS) Questionnaire: a New Validated Tool to Quantify the Patients' Compliance to Post-Bariatric Dietary and Lifestyle Suggestions. Obes Surg. 2020 Oct; 30(10):3831-3838. Spaggiari G, Santi D, Budriesi G, Dondi P, Cavedoni S, Leonardi L, Delvecchio C, Valentini L, Bondi M, Miloro C, Toschi PF. PMID: 32447636.
      View in: PubMed   Mentions:    Fields:    
    13. Interleukin 15 Pharmacokinetics and Consumption by a Dynamic Cytokine Sink. Front Immunol. 2020; 11:1813. Hangasky JA, Waldmann TA, Santi DV. PMID: 32903632.
      View in: PubMed   Mentions: 1     Fields:    
    14. Effects of acute hCG stimulation on serum INSL3 and 25-OH vitamin D in Klinefelter syndrome. Andrology. 2020 11; 8(6):1720-1727. Santi D, Ivell R, Anand-Ivell R, De Toni L, Fanelli F, Mezzullo M, Pelusi C, Pagotto U, Belli S, Granata ARM, Roli L, Rochira V, Trenti T, Ferlin A, Simoni M. PMID: 32593193.
      View in: PubMed   Mentions:    Fields:    
    15. Prospects for FSH Treatment of Male Infertility. J Clin Endocrinol Metab. 2020 Jul 01; 105(7). Simoni M, Brigante G, Rochira V, Santi D, Casarini L. PMID: 32374828.
      View in: PubMed   Mentions:    Fields:    
    16. Multilevel approach to male fertility by machine learning highlights a hidden link between haematological and spermatogenetic cells. Andrology. 2020 09; 8(5):1021-1029. Santi D, Spaggiari G, Casonati A, Casarini L, Grassi R, Vecchi B, Roli L, De Santis MC, Orlando G, Gravotta E, Baraldi E, Setti M, Trenti T, Simoni M. PMID: 32449608.
      View in: PubMed   Mentions:    Fields:    
    17. To beer or not to beer: A meta-analysis of the effects of beer consumption on cardiovascular health. PLoS One. 2020; 15(6):e0233619. Spaggiari G, Cignarelli A, Sansone A, Baldi M, Santi D. PMID: 32492025.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Testicular ultrasound inhomogeneity is an informative parameter for fertility evaluation. Asian J Androl. 2020 May-Jun; 22(3):302-308. Spaggiari G, M Granata AR, Santi D. PMID: 31274478.
      View in: PubMed   Mentions: 1     Fields:    
    19. Follicle-stimulating Hormone (FSH) Action on Spermatogenesis: A Focus on Physiological and Therapeutic Roles. J Clin Med. 2020 Apr 03; 9(4). Santi D, Crépieux P, Reiter E, Spaggiari G, Brigante G, Casarini L, Rochira V, Simoni M. PMID: 32260182.
      View in: PubMed   Mentions:
    20. FSH for the Treatment of Male Infertility. Int J Mol Sci. 2020 Mar 25; 21(7). Casarini L, Crépieux P, Reiter E, Lazzaretti C, Paradiso E, Rochira V, Brigante G, Santi D, Simoni M. PMID: 32218314.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    21. The physician's gender influences the results of the diagnostic workup for erectile dysfunction. Andrology. 2020 05; 8(3):671-679. Rastrelli G, Cipriani S, Craparo A, De Vincentis S, Granata ARM, Spaggiari G, Simoni M, Maggi M, Santi D. PMID: 31955507.
      View in: PubMed   Mentions:    Fields:    
    22. Prospective use of the single-mouse experimental design for the evaluation of PLX038A. Cancer Chemother Pharmacol. 2020 02; 85(2):251-263. Ghilu S, Li Q, Fontaine SD, Santi DV, Kurmasheva RT, Zheng S, Houghton PJ. PMID: 31927611.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    23. Seasonal Changes of Serum Gonadotropins and Testosterone in Men Revealed by a Large Data Set of Real-World Observations Over Nine Years. Front Endocrinol (Lausanne). 2019; 10:914. Santi D, Spaggiari G, Granata ARM, Setti M, Tagliavini S, Trenti T, Simoni M. PMID: 31998242.
      View in: PubMed   Mentions:
    24. FSH treatment of male idiopathic infertility: Time for a paradigm change. Andrology. 2020 05; 8(3):535-544. Simoni M, Santi D. PMID: 31872552.
      View in: PubMed   Mentions: 1     Fields:    
    25. Use of follicle-stimulating hormone for the male partner of idiopathic infertile couples in Italy: Results from a multicentre, observational, clinical practice survey. Andrology. 2020 05; 8(3):637-644. Santi D, De Vincentis S, Alfano P, Balercia G, Calogero AE, Cargnelutti F, Coccia ME, Condorelli RA, Dal Lago A, de Angelis C, Gallo M, Iannantuoni N, Lombardo F, Marino A, Mazzella M, Pallotti F, Paoli D, Pivonello R, Rago R, Rampini M, Salvio G, Simoni M. PMID: 31872967.
      View in: PubMed   Mentions: 1     Fields:    
    26. An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men. Andrology. 2020 01; 8(1):53-81. Esteves SC, Santi D, Simoni M. PMID: 31692293.
      View in: PubMed   Mentions: 2     Fields:    
    27. PET Imaging of the EPR Effect in Tumor Xenografts Using Small 15 nm Diameter Polyethylene Glycols Labeled with Zirconium-89. . 2020 02; 19(2):673-679. Beckford Vera DR, Fontaine SD, VanBrocklin HF, Hearn BR, Reid R, Ashley GW, Santi DV. PMID: 31744896.
      View in: PubMed   Mentions:
    28. PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity. Cancer Chemother Pharmacol. 2020 01; 85(1):225-229. Fontaine SD, Santi AD, Reid R, Smith PC, Ashley GW, Santi DV. PMID: 31707444.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    29. Editorial: Follicle-Stimulating Hormone: Fertility and Beyond. Front Endocrinol (Lausanne). 2019; 10:610. Simoni M, Huhtaniemi I, Santi D, Casarini L. PMID: 31551936.
      View in: PubMed   Mentions:
    30. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study. Endocr Connect. 2019 Aug 01; 8(8):1118-1125. Melcangi RC, Casarini L, Marino M, Santi D, Sperduti S, Giatti S, Diviccaro S, Grimoldi M, Caruso D, Cavaletti G, Simoni M. PMID: 31272082.
      View in: PubMed   Mentions:
    31. Semi-annual seasonal pattern of serum thyrotropin in adults. Sci Rep. 2019 07 25; 9(1):10786. Santi D, Spaggiari G, Brigante G, Setti M, Tagliavini S, Trenti T, Simoni M. PMID: 31346248.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Species-specific optimization of PEG~SN-38 prodrug pharmacokinetics and antitumor effects in a triple-negative BRCA1-deficient xenograft. Cancer Chemother Pharmacol. 2019 10; 84(4):729-738. Fontaine SD, Hann B, Reid R, Ashley GW, Santi DV. PMID: 31321449.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    33. A once-monthly GLP-1 receptor agonist for treatment of diabetic cats. Domest Anim Endocrinol. 2020 01; 70:106373. Schneider EL, Reid R, Parkes DG, Lutz TA, Ashley GW, Santi DV. PMID: 31479925.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    34. Effect of treatment with testosterone on endothelial function in hypogonadal men: a systematic review and meta-analysis. Int J Impot Res. 2020 Jul; 32(4):379-386. Sansone A, Rastrelli G, Cignarelli A, de Rocco Ponce M, Condorelli RA, Giannetta E, Maseroli E, Pinto S, Salzano C, Santi D. PMID: 31235898.
      View in: PubMed   Mentions: 3     Fields:    
    35. An Observational Retrospective Cohort Trial on 4,828 IVF Cycles Evaluating Different Low Prognosis Patients Following the POSEIDON Criteria. Front Endocrinol (Lausanne). 2019; 10:282. Levi-Setti PE, Zerbetto I, Baggiani A, Zannoni E, Sacchi L, Smeraldi A, Morenghi E, De Cesare R, Drovanti A, Santi D. PMID: 31139146.
      View in: PubMed   Mentions:
    36. Relative hyperestrogenism in Klinefelter Syndrome: results from a meta-analysis. Endocrine. 2019 05; 64(2):209-219. Santi D, De Vincentis S, Scaltriti S, Rochira V. PMID: 30701446.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. Expression and clinicopathological role of miR146a in thyroid follicular carcinoma. Endocrine. 2019 06; 64(3):575-583. Pignatti E, Vighi E, Magnani E, Kara E, Roncati L, Maiorana A, Santi D, Madeo B, Cioni K, Carani C, Rochira V, Simoni M, Brigante G. PMID: 30701447.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis. Int J Mol Sci. 2019 Jan 16; 20(2). Potì F, Santi D, Spaggiari G, Zimetti F, Zanotti I. PMID: 30654461.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    39. Two Hormones for One Receptor: Evolution, Biochemistry, Actions, and Pathophysiology of LH and hCG. Endocr Rev. 2018 10 01; 39(5):549-592. Casarini L, Santi D, Brigante G, Simoni M. PMID: 29905829.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    40. Clinical relevance of genetic variants of gonadotrophins and their receptors in controlled ovarian stimulation: a systematic review and meta-analysis. Hum Reprod Update. 2018 09 01; 24(5):599-614. Alviggi C, Conforti A, Santi D, Esteves SC, Andersen CY, Humaidan P, Chiodini P, De Placido G, Simoni M. PMID: 29924306.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    41. A Controlled Release System for Long-Acting Intravitreal Delivery of Small Molecules. Transl Vis Sci Technol. 2018 Jul; 7(4):21. Machinaga N, Ashley GW, Reid R, Yamasaki A, Tanaka K, Nakamura K, Yabe Y, Yoshigae Y, Santi DV. PMID: 30174998.
      View in: PubMed   Mentions:
    42. Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management - meta-analyses. Reprod Biomed Online. 2018 09; 37(3):315-326. Santi D, Spaggiari G, Simoni M. PMID: 30314886.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    43. Could chronic Vardenafil administration influence the cardiovascular risk in men with type 2 diabetes mellitus? PLoS One. 2018; 13(6):e0199299. Santi D, Locaso M, Granata AR, Trenti T, Roli L, Pacchioni C, Rochira V, Carani C, Simoni M. PMID: 29953477.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    44. AN ITALIAN SURVEY OF COMPLIANCE WITH MAJOR GUIDELINES FOR L-THYROXINE OF PRIMARY HYPOTHYROIDISM. Endocr Pract. 2018 May; 24(5):419-428. Vezzani S, Giannetta E, Altieri B, Barbonetti A, Bellastella G, Certo R, Cignarelli A, Cinti F, D'Andrea S, Di Dalmazi G, Frara S, Garelli S, Giuffrida G, Maiorino MI, Mele C, Mezza T, Pani MG, Samà MT, Satta C, Santi D. PMID: 29847168.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    45. Response: Commentary: Efficacy of Follicle-Stimulating Hormone (FSH) Alone, FSH?+?Luteinizing Hormone, Human Menopausal Gonadotropin or FSH?+?Human Chorionic Gonadotropin on Assisted Reproductive Technology Outcomes in the "Personalized" Medicine Era: A Meta-analysis. Front Endocrinol (Lausanne). 2018; 9:113. Santi D, Casarini L, Alviggi C, Simoni M. PMID: 29628912.
      View in: PubMed   Mentions:
    46. Primary deuterium kinetic isotope effects prolong drug release and polymer biodegradation in a drug delivery system. J Control Release. 2018 05 28; 278:74-79. Hearn BR, Fontaine SD, Pfaff SJ, Schneider EL, Henise J, Ashley GW, Santi DV. PMID: 29577950.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    47. Seasonal variation of semen parameters correlates with environmental temperature and air pollution: A big data analysis over 6 years. Environ Pollut. 2018 Apr; 235:806-813. Santi D, Magnani E, Michelangeli M, Grassi R, Vecchi B, Pedroni G, Roli L, De Santis MC, Baraldi E, Setti M, Trenti T, Simoni M. PMID: 29353799.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    48. 'Spare' Luteinizing Hormone Receptors: Facts and Fiction. Trends Endocrinol Metab. 2018 04; 29(4):208-217. Casarini L, Santi D, Simoni M, Potì F. PMID: 29429918.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    49. Pharmacogenetics of G-protein-coupled receptors variants: FSH receptor and infertility treatment. Best Pract Res Clin Endocrinol Metab. 2018 04; 32(2):189-200. Santi D, Potì F, Simoni M, Casarini L. PMID: 29678285.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    50. Probiotics Ingestion Does Not Directly Affect Thyroid Hormonal Parameters in Hypothyroid Patients on Levothyroxine Treatment. Front Endocrinol (Lausanne). 2017; 8:316. Spaggiari G, Brigante G, De Vincentis S, Cattini U, Roli L, De Santis MC, Baraldi E, Tagliavini S, Varani M, Trenti T, Rochira V, Simoni M, Santi D. PMID: 29184537.
      View in: PubMed   Mentions:
    51. Serum Calcium to Phosphorous (Ca/P) Ratio Is a Simple, Inexpensive, and Accurate Tool in the Diagnosis of Primary Hyperparathyroidism. JBMR Plus. 2018 Mar; 2(2):109-117. Madeo B, Kara E, Cioni K, Vezzani S, Trenti T, Santi D, Simoni M, Rochira V. PMID: 30283895.
      View in: PubMed   Mentions:
    52. Gene Expression and Apoptosis Levels in Cumulus Cells of Patients with Polymorphisms of FSHR and LHB Undergoing in Vitro Fertilization Program. Cell Physiol Biochem. 2017; 43(6):2391-2404. Bosco L, Ruvolo G, Luparello C, Ferrari S, Valerio D, Santi D, Piomboni P, Sarcina E, Lispi M, Roccheri MC. PMID: 29073627.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    53. Molecular basis of androgen action on human sexual desire. Mol Cell Endocrinol. 2018 05 15; 467:31-41. Santi D, Spaggiari G, Gilioli L, Potì F, Simoni M, Casarini L. PMID: 28893567.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    54. A Hydrogel-Microsphere Drug Delivery System That Supports Once-Monthly Administration of a GLP-1 Receptor Agonist. ACS Chem Biol. 2017 08 18; 12(8):2107-2116. Schneider EL, Hearn BR, Pfaff SJ, Reid R, Parkes DG, Vrang N, Ashley GW, Santi DV. PMID: 28605180.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    55. Advances in Robotic Transaxillary Thyroidectomy in Europe. Curr Surg Rep. 2017; 5(8):17. Piccoli M, Mullineris B, Santi D, Gozzo D. PMID: 28680769.
      View in: PubMed   Mentions:
    56. Efficacy of Follicle-Stimulating Hormone (FSH) Alone, FSH?+?Luteinizing Hormone, Human Menopausal Gonadotropin or FSH?+?Human Chorionic Gonadotropin on Assisted Reproductive Technology Outcomes in the "Personalized" Medicine Era: A Meta-analysis. Front Endocrinol (Lausanne). 2017; 8:114. Santi D, Casarini L, Alviggi C, Simoni M. PMID: 28620352.
      View in: PubMed   Mentions:
    57. Genetics of gonadotropins and their receptors as markers of ovarian reserve and response in controlled ovarian stimulation. Best Pract Res Clin Obstet Gynaecol. 2017 Oct; 44:15-25. Riccetti L, De Pascali F, Gilioli L, Santi D, Brigante G, Simoni M, Casarini L. PMID: 28506471.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    58. Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients. J Steroid Biochem Mol Biol. 2017 07; 171:229-235. Melcangi RC, Santi D, Spezzano R, Grimoldi M, Tabacchi T, Fusco ML, Diviccaro S, Giatti S, Carrà G, Caruso D, Simoni M, Cavaletti G. PMID: 28408350.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    59. Central hypogonadism due to a giant, "silent" FSH-secreting, atypical pituitary adenoma: effects of adenoma dissection and short-term Leydig cell stimulation by luteinizing hormone (LH) and human chorionic gonadotropin (hCG). Aging Male. 2017 Jun; 20(2):96-101. Santi D, Spaggiari G, Casarini L, Fanelli F, Mezzullo M, Pagotto U, Granata ARM, Carani C, Simoni M. PMID: 28067604.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    60. Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake. Bioconjug Chem. 2016 Oct 19; 27(10):2534-2539. Schneider EL, Hearn BR, Pfaff SJ, Fontaine SD, Reid R, Ashley GW, Grabulovski S, Strassberger V, Vogt L, Jung T, Santi DV. PMID: 27657443.
      View in: PubMed   Mentions: 2     Fields:    
    61. Effects of chronic administration of the phosphodiesterase inhibitor vardenafil on serum levels of adrenal and testicular steroids in men with type 2 diabetes mellitus. Endocrine. 2017 May; 56(2):426-437. Santi D, Granata AR, Pignatti E, Trenti T, Roli L, Bozic R, Zaza S, Pacchioni C, Rochira V, Carani C, Simoni M. PMID: 27515804.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    62. Subcutaneously Administered Self-Cleaving Hydrogel-Octreotide Conjugates Provide Very Long-Acting Octreotide. Bioconjug Chem. 2016 07 20; 27(7):1638-44. Schneider EL, Henise J, Reid R, Ashley GW, Santi DV. PMID: 27253622.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    63. Treatment with human, recombinant FSH improves sperm DNA fragmentation in idiopathic infertile men depending on the FSH receptor polymorphism p.N680S: a pharmacogenetic study. Hum Reprod. 2016 09; 31(9):1960-9. Simoni M, Santi D, Negri L, Hoffmann I, Muratori M, Baldi E, Cambi M, Marcou M, Greither T, Baraldi E, Tagliavini S, Carra D, Lombardo F, Gandini L, Pallotti F, Krausz C, Rastrelli G, Ferlin A, Menegazzo M, Pignatti E, Linari F, Marino M, Benaglia R, Levi-Setti PE, Behre HM. PMID: 27329968.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsCTClinical Trials
    64. Sperm quality and environment: A retrospective, cohort study in a Northern province of Italy. Environ Res. 2016 10; 150:144-153. Santi D, Vezzani S, Granata AR, Roli L, De Santis MC, Ongaro C, Donati F, Baraldi E, Trenti T, Setti M, Simoni M. PMID: 27288912.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    65. Surgical sealants with tunable swelling, burst pressures, and biodegradation rates. . 2017 08; 105(6):1602-1611. Henise J, Hearn BR, Santi DV, Kamata H, Sakai T, Ashley GW. PMID: 27149244.
      View in: PubMed   Mentions:
    66. Hydrogel Drug Delivery System Using Self-Cleaving Covalent Linkers for Once-a-Week Administration of Exenatide. Bioconjug Chem. 2016 05 18; 27(5):1210-5. Schneider EL, Henise J, Reid R, Ashley GW, Santi DV. PMID: 26930186.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    67. Six months of daily treatment with vardenafil improves parameters of endothelial inflammation and of hypogonadism in male patients with type 2 diabetes and erectile dysfunction: a randomized, double-blind, prospective trial. Eur J Endocrinol. 2016 Apr; 174(4):513-22. Santi D, Granata AR, Guidi A, Pignatti E, Trenti T, Roli L, Bozic R, Zaza S, Pacchioni C, Romano S, Nofer JR, Rochira V, Carani C, Simoni M. PMID: 26792933.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    68. Impact of gene polymorphisms of gonadotropins and their receptors on human reproductive success. Reproduction. 2015 Dec; 150(6):R175-84. Casarini L, Santi D, Marino M. PMID: 26370242.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    69. High-Resolution Melting Is a Sensitive, Cost-Effective, Time-Saving Technique for BRAF V600E Detection in Thyroid FNAB Washing Liquid: A Prospective Cohort Study. Eur Thyroid J. 2015 Jun; 4(2):73-81. Marino M, Monzani ML, Brigante G, Cioni K, Madeo B, Santi D, Maiorana A, Bettelli S, Moriondo V, Pignatti E, Bonacini L, Carani C, Rochira V, Simoni M. PMID: 26279992.
      View in: PubMed   Mentions:
    70. Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology. Eur J Pharm Biopharm. 2015 Jun; 93:254-9. Schneider EL, Ashley GW, Dillen L, Stoops B, Austin NE, Malcolm BA, Santi DV. PMID: 25900863.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    71. Erectile Dysfunction is Common among Men with Acromegaly and is Associated with Morbidities Related to the Disease. J Sex Med. 2015 May; 12(5):1184-93. Lotti F, Rochira V, Pivonello R, Santi D, Galdiero M, Maseroli E, Balestrieri A, Faustini-Fustini M, Peri A, Sforza A, Colao A, Maggi M, Corona G. PMID: 25736192.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    72. Biodegradable tetra-PEG hydrogels as carriers for a releasable drug delivery system. Bioconjug Chem. 2015 Feb 18; 26(2):270-8. Henise J, Hearn BR, Ashley GW, Santi DV. PMID: 25584814.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    73. Long-term stabilization of maleimide-thiol conjugates. Bioconjug Chem. 2015 Jan 21; 26(1):145-52. Fontaine SD, Reid R, Robinson L, Ashley GW, Santi DV. PMID: 25494821.
      View in: PubMed   Mentions: 35     Fields:    
    74. Therapy of endocrine disease. Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis. Eur J Endocrinol. 2015 Mar; 172(3):R103-14. Santi D, Giannetta E, Isidori AM, Vitale C, Aversa A, Simoni M. PMID: 25277671.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    75. The TRHR Gene Is Associated with Hypothalamo-Pituitary Sensitivity to Levothyroxine. Eur Thyroid J. 2014 Jun; 3(2):101-8. Brigante G, Spaggiari G, Santi D, Cioni K, Gnarini V, Diazzi C, Pignatti E, Casarini L, Marino M, Tüttelmann F, Carani C, Simoni M. PMID: 25114873.
      View in: PubMed   Mentions:
    76. Biosimilar recombinant follicle stimulating hormones in infertility treatment. Expert Opin Biol Ther. 2014 Oct; 14(10):1399-409. Santi D, Simoni M. PMID: 24889801.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    77. Macromolecular prodrug that provides the irinotecan (CPT-11) active-metabolite SN-38 with ultralong half-life, low C(max), and low glucuronide formation. J Med Chem. 2014 Mar 27; 57(6):2303-14. Santi DV, Schneider EL, Ashley GW. PMID: 24494988.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    78. Male sexual dysfunction and HIV--a clinical perspective. Nat Rev Urol. 2014 Feb; 11(2):99-109. Santi D, Brigante G, Zona S, Guaraldi G, Rochira V. PMID: 24394405.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    79. ß-Eliminative releasable linkers adapted for bioconjugation of macromolecules to phenols. Bioconjug Chem. 2013 Dec 18; 24(12):1990-7. Schneider EL, Robinson L, Reid R, Ashley GW, Santi DV. PMID: 24171387.
      View in: PubMed   Mentions:    Fields:    
    80. The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res. 2014 Feb; 42(3):2037-48. Czudnochowski N, Ashley GW, Santi DV, Alian A, Finer-Moore J, Stroud RM. PMID: 24214967.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    81. Hydrogel drug delivery system with predictable and tunable drug release and degradation rates. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2318-23. Ashley GW, Henise J, Reid R, Santi DV. PMID: 23345437.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    82. Erectile dysfunction is more common in young to middle-aged HIV-infected men than in HIV-uninfected men. J Sex Med. 2012 Jul; 9(7):1923-30. Zona S, Guaraldi G, Luzi K, Beggi M, Santi D, Stentarelli C, Madeo B, Rochira V. PMID: 22548701.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    83. Predictable and tunable half-life extension of therapeutic agents by controlled chemical release from macromolecular conjugates. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6211-6. Santi DV, Schneider EL, Reid R, Robinson L, Ashley GW. PMID: 22474378.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    84. Premature decline of serum total testosterone in HIV-infected men in the HAART-era. PLoS One. 2011; 6(12):e28512. Rochira V, Zirilli L, Orlando G, Santi D, Brigante G, Diazzi C, Carli F, Carani C, Guaraldi G. PMID: 22174826.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    85. Using chemobiosynthesis and synthetic mini-polyketide synthases to produce pharmaceutical intermediates in Escherichia coli. Appl Environ Microbiol. 2010 Aug; 76(15):5221-7. Menzella HG, Carney JR, Li Y, Santi DV. PMID: 20543042.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    86. Synthesis of methyl halides from biomass using engineered microbes. J Am Chem Soc. 2009 May 13; 131(18):6508-15. Bayer TS, Widmaier DM, Temme K, Mirsky EA, Santi DV, Voigt CA. PMID: 19378995.
      View in: PubMed   Mentions: 73     Fields:    Translation:Cells
    87. Molecular modeling and crystal structure of ERK2-hypothemycin complexes. J Struct Biol. 2008 Oct; 164(1):18-23. Rastelli G, Rosenfeld R, Reid R, Santi DV. PMID: 18571434.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    88. Semisynthesis and cytotoxicity of hypothemycin analogues. ChemMedChem. 2007 Nov; 2(11):1598-600. Hearn BR, Sundermann K, Cannoy J, Santi DV. PMID: 17691074.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    89. Rational design and assembly of synthetic trimodular polyketide synthases. Chem Biol. 2007 Feb; 14(2):143-51. Menzella HG, Carney JR, Santi DV. PMID: 17317568.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    90. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20; 45(24):7415-28. Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM. PMID: 16768437.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    91. Activating hybrid modular interfaces in synthetic polyketide synthases by cassette replacement of ketosynthase domains. Chem Biol. 2006 May; 13(5):469-74. Chandran SS, Menzella HG, Carney JR, Santi DV. PMID: 16720267.
      View in: PubMed   Mentions: 7     Fields:    
    92. Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4234-9. Schirmer A, Kennedy J, Murli S, Reid R, Santi DV. PMID: 16537514.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    93. Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster. J Ind Microbiol Biotechnol. 2006 Jan; 33(1):22-8. Menzella HG, Reisinger SJ, Welch M, Kealey JT, Kennedy J, Reid R, Tran CQ, Santi DV. PMID: 16187094.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    94. Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. Nat Biotechnol. 2005 Sep; 23(9):1171-6. Menzella HG, Reid R, Carney JR, Chandran SS, Reisinger SJ, Patel KG, Hopwood DA, Santi DV. PMID: 16116420.
      View in: PubMed   Mentions: 90     Fields:    Translation:Cells
    95. GeMS: an advanced software package for designing synthetic genes. Nucleic Acids Res. 2005; 33(9):3011-6. Jayaraj S, Reid R, Santi DV. PMID: 15911632.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    96. Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster. Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44):15573-8. Kodumal SJ, Patel KG, Reid R, Menzella HG, Welch M, Santi DV. PMID: 15496466.
      View in: PubMed   Mentions: 70     Fields:    Translation:Cells
    97. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. Bioorg Med Chem. 2004 Oct 15; 12(20):5317-29. Tian ZQ, Liu Y, Zhang D, Wang Z, Dong SD, Carreras CW, Zhou Y, Rastelli G, Santi DV, Myles DC. PMID: 15388159.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    98. DNA ligation by selection. Biotechniques. 2004 Jul; 37(1):34, 36, 38 passim. Kodumal SJ, Santi DV. PMID: 15283197.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    99. A sensitive and robust method for quantification of intracellular short-chain coenzyme A esters. Anal Biochem. 2004 May 01; 328(1):51-9. Shimazu M, Vetcher L, Galazzo JL, Licari P, Santi DV. PMID: 15081907.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    100. The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase. Protein Eng. 2003 Aug; 16(8):607-14. Gonzalez-Pacanowska D, Ruiz-Perez LM, Carreras-Gómez MA, Costi MP, Stroud RM, Finer-Moore J, Santi DV. PMID: 12968078.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    101. Filter binding assay for the geldanamycin-heat shock protein 90 interaction. Anal Biochem. 2003 Jun 01; 317(1):40-6. Carreras CW, Schirmer A, Zhong Z, Santi DV. PMID: 12729599.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    102. Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. Chem Biol. 2003 Apr; 10(4):361-8. Jez JM, Chen JC, Rastelli G, Stroud RM, Santi DV. PMID: 12725864.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    103. Approaches to stabilization of inter-domain recombination in polyketide synthase gene expression plasmids. J Ind Microbiol Biotechnol. 2003 Mar; 30(3):161-7. Hu Z, Desai RP, Volchegursky Y, Leaf T, Woo E, Licari P, Santi DV, Hutchinson CR, McDaniel R. PMID: 12715253.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    104. Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. Biochemistry. 2003 Jan 21; 42(2):248-56. Finer-Moore JS, Santi DV, Stroud RM. PMID: 12525151.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    105. A model of structure and catalysis for ketoreductase domains in modular polyketide synthases. Biochemistry. 2003 Jan 14; 42(1):72-9. Reid R, Piagentini M, Rodriguez E, Ashley G, Viswanathan N, Carney J, Santi DV, Hutchinson CR, McDaniel R. PMID: 12515540.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    106. Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry. 2002 Apr 23; 41(16):5193-201. Dayem LC, Carney JR, Santi DV, Pfeifer BA, Khosla C, Kealey JT. PMID: 11955068.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    107. Stable expression of a synthetic gene for the human motilin receptor: use in an aequorin-based receptor activation assay. Anal Biochem. 2002 Jan 15; 300(2):146-51. Carreras CW, Siani MA, Santi DV, Dillon SB. PMID: 11779105.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    108. Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. J Biol Chem. 2002 Mar 15; 277(11):8835-40. Agarwalla S, Kealey JT, Santi DV, Stroud RM. PMID: 11779873.
      View in: PubMed   Mentions: 36     Fields:    Translation:Cells
    109. An FKBP12 binding assay based upon biotinylated FKBP12. Anal Biochem. 2001 Nov 01; 298(1):57-61. Carreras CW, Fu H, Santi DV. PMID: 11673895.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    110. Development and screening of a polyketide virtual library for drug leads against a motilide pharmacophore. J Mol Graph Model. 2000 Aug-Oct; 18(4-5):497-511, 539-40. Siani MA, Skillman AG, Carreras CW, Ashley G, Kuntz ID, Santi DV. PMID: 11143565.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    111. Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase. Protein Eng. 2000 Aug; 13(8):557-63. Kawase S, Cho SW, Rozelle J, Stroud RM, Finer-Moore J, Santi DV. PMID: 10964985.
      View in: PubMed   Mentions: 6     Fields:    
    112. m5C RNA and m5C DNA methyl transferases use different cysteine residues as catalysts. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8263-5. Liu Y, Santi DV. PMID: 10899996.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    113. An approach for obtaining perfect hybridization probes for unknown polyketide synthase genes: a search for the epothilone gene cluster. Gene. 2000 Apr 18; 247(1-2):97-102. Santi DV, Siani MA, Julien B, Kupfer D, Roe B. PMID: 10773448.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    114. Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants. Biochemistry. 2000 Mar 14; 39(10):2429-35. Variath P, Liu Y, Lee TT, Stroud RM, Santi DV. PMID: 10704192.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    115. Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance". Biochemistry. 2000 Feb 08; 39(5):1011-20. Morse RJ, Kawase S, Santi DV, Finer-Moore J, Stroud RM. PMID: 10653645.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    116. The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I. Nat Struct Biol. 2000 Jan; 7(1):23-7. Foster PG, Huang L, Santi DV, Stroud RM. PMID: 10625422.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    117. Mechanistic studies of RNA modifying enzymes. RNA pseudouridine synthase and m5cytosine methyl transferase. Nucleic Acids Symp Ser. 2000; (44):147-8. Santi DV. PMID: 12903311.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    118. The mechanism of pseudouridine synthase I as deduced from its interaction with 5-fluorouracil-tRNA. Proc Natl Acad Sci U S A. 1999 Dec 07; 96(25):14270-5. Gu X, Liu Y, Santi DV. PMID: 10588695.
      View in: PubMed   Mentions: 45     Fields:    
    119. Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli. J Bacteriol. 1999 Nov; 181(21):6814-21. Nopponpunth V, Sirawaraporn W, Greene PJ, Santi DV. PMID: 10542185.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    120. A multiplasmid approach to preparing large libraries of polyketides. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):11740-5. Xue Q, Ashley G, Hutchinson CR, Santi DV. PMID: 10518520.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    121. Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences. Nucleic Acids Res. 1999 Aug 01; 27(15):3138-45. Reid R, Greene PJ, Santi DV. PMID: 10454610.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    122. Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. J Med Chem. 1999 Jun 17; 42(12):2112-24. Costi PM, Rinaldi M, Tondi D, Pecorari P, Barlocco D, Ghelli S, Stroud RM, Santi DV, Stout TJ, Musiu C, Marangiu EM, Pani A, Congiu D, Loi GA, La Colla P. PMID: 10377217.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    123. Disulfide engineering at the dimer interface of Lactobacillus casei thymidylate synthase: crystal structure of the T155C/E188C/C244T mutant. Protein Sci. 1999 Apr; 8(4):930-3. Velanker SS, Gokhale RS, Ray SS, Gopal B, Parthasarathy S, Santi DV, Balaram P, Murthy MR. PMID: 10211840.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    124. Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli. Biochemistry. 1999 Mar 30; 38(13):4053-7. Gu XR, Gustafsson C, Ku J, Yu M, Santi DV. PMID: 10194318.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    125. Effect of amino acid substitutions at the subunit interface on the stability and aggregation properties of a dimeric protein: role of Arg 178 and Arg 218 at the Dimer interface of thymidylate synthase. Proteins. 1999 Feb 15; 34(3):356-68. Prasanna V, Gopal B, Murthy MR, Santi DV, Balaram P. PMID: 10024022.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    126. Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry. 1999 Feb 02; 38(5):1607-17. Stout TJ, Tondi D, Rinaldi M, Barlocco D, Pecorari P, Santi DV, Kuntz ID, Stroud RM, Shoichet BK, Costi MP. PMID: 9931028.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    127. Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2'-deoxyuridine 5'-monophosphate. Biochemistry. 1999 Jan 12; 38(2):848-52. Liu Y, Barrett JE, Schultz PG, Santi DV. PMID: 9888826.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    128. A continuous spectrophotometric assay for thymidine and deoxycytidine kinases. Anal Biochem. 1998 Nov 15; 264(2):259-62. Liu Y, Santi DV. PMID: 9866691.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    129. Identification of two Escherichia coli pseudouridine synthases that show multisite specificity for 23S RNA. Biochemistry. 1998 Nov 10; 37(45):15951-7. Huang L, Ku J, Pookanjanatavip M, Gu X, Wang D, Greene PJ, Santi DV. PMID: 9843401.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    130. Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis. Biochemistry. 1998 Oct 20; 37(42):14736-47. Stout TJ, Schellenberger U, Santi DV, Stroud RM. PMID: 9778348.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    131. Aspartate 221 of thymidylate synthase is involved in folate cofactor binding and in catalysis. Biochemistry. 1998 Jun 23; 37(25):9038-42. Chiericatti G, Santi DV. PMID: 9636048.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    132. The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. Protein Eng. 1998 Mar; 11(3):171-83. Birdsall DL, Huang W, Santi DV, Stroud RM, Finer-Moore J. PMID: 9613841.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    133. Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase. J Mol Biol. 1998 Feb 13; 276(1):113-29. Finer-Moore JS, Liu L, Birdsall DL, Brem R, Apfeld J, Santi DV, Stroud RM. PMID: 9514716.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    134. Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts. Proc Natl Acad Sci U S A. 1998 Jan 20; 95(2):505-9. Kealey JT, Liu L, Santi DV, Betlach MC, Barr PJ. PMID: 9435221.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    135. Molecular recognition of tRNA by tRNA pseudouridine 55 synthase. Biochemistry. 1998 Jan 06; 37(1):339-43. Gu X, Yu M, Ivanetich KM, Santi DV. PMID: 9425055.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    136. A conserved aspartate of tRNA pseudouridine synthase is essential for activity and a probable nucleophilic catalyst. Biochemistry. 1998 Jan 06; 37(1):344-51. Huang L, Pookanjanatavip M, Gu X, Santi DV. PMID: 9425056.
      View in: PubMed   Mentions: 64     Fields:    Translation:Cells
    137. A novel dCMP methylase by engineering thymidylate synthase. Biochemistry. 1997 Dec 16; 36(50):15909-17. Agarwalla S, LaPorte S, Liu L, Finer-Moore J, Stroud RM, Santi DV. PMID: 9398324.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    138. Plasmodium falciparum: asparagine mutant at residue 108 of dihydrofolate reductase is an optimal antifolate-resistant single mutant. Exp Parasitol. 1997 Nov; 87(3):245-52. Sirawaraporn W, Yongkiettrakul S, Sirawaraporn R, Yuthavong Y, Santi DV. PMID: 9371090.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    139. Specificity in structure-based drug design: identification of a novel, selective inhibitor of Pneumocystis carinii dihydrofolate reductase. Proteins. 1997 Sep; 29(1):59-67. Gschwend DA, Sirawaraporn W, Santi DV, Kuntz ID. PMID: 9294866.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    140. Construction of a homodimeric dihydrofolate reductase-thymidylate synthase bifunctional enzyme. Protein Eng. 1997 May; 10(5):567-73. Trujillo M, Duncan R, Santi DV. PMID: 9215575.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    141. The dynamic NMR structure of the T psi C-loop: implications for the specificity of tRNA methylation. J Biomol NMR. 1997 Apr; 9(3):229-44. Yao LJ, James TL, Kealey JT, Santi DV, Schmitz U. PMID: 9204554.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    142. Expression of a functional non-ribosomal peptide synthetase module in Escherichia coli by coexpression with a phosphopantetheinyl transferase. Chem Biol. 1997 Mar; 4(3):203-7. Ku J, Mirmira RG, Liu L, Santi DV. PMID: 9115412.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    143. Active site general catalysts are not necessary for some proton transfer reactions of thymidylate synthase. Biochemistry. 1997 Feb 18; 36(7):1869-73. Huang W, Santi DV. PMID: 9048572.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    144. Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1124-9. Sirawaraporn W, Sathitkul T, Sirawaraporn R, Yuthavong Y, Santi DV. PMID: 9037017.
      View in: PubMed   Mentions: 86     Fields:    Translation:Animals
    145. Chemical synthesis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene. Mol Biochem Parasitol. 1996 Dec 02; 83(1):93-106. Prapunwattana P, Sirawaraporn W, Yuthavong Y, Santi DV. PMID: 9010845.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    146. Identification of new RNA modifying enzymes by iterative genome search using known modifying enzymes as probes. Nucleic Acids Res. 1996 Oct 01; 24(19):3756-62. Gustafsson C, Reid R, Greene PJ, Santi DV. PMID: 8871555.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    147. Recognition of the T-arm of tRNA by tRNA (m5U54)-methyltransferase is not sequence specific. Biochemistry. 1996 Sep 10; 35(36):11652-9. Gu X, Ivanetich KM, Santi DV. PMID: 8794745.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    148. Functional expression of the dihydrofolate reductase domain of Leishmania major dihydrofolate reductase-thymidylate synthase bifunctional protein. Protein Expr Purif. 1996 Aug; 8(1):23-7. Yu PL, Zhao J, Yu M, Reid R, Santi DV. PMID: 8812831.
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    149. Covalent reinforcement of a fragile region in the dimeric enzyme thymidylate synthase stabilizes the protein against chaotrope-induced unfolding. Biochemistry. 1996 Jun 04; 35(22):7150-8. Gokhale RS, Agarwalla S, Santi DV, Balaram P. PMID: 8679542.
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    150. Heterologous expression and characterization of the bifunctional dihydrofolate reductase-thymidylate synthase enzyme of Toxoplasma gondii. Biochemistry. 1996 May 21; 35(20):6366-74. Trujillo M, Donald RG, Roos DS, Greene PJ, Santi DV. PMID: 8639582.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    151. Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry. 1996 Apr 23; 35(16):5125-36. Finer-Moore JS, Liu L, Schafmeister CE, Birdsall DL, Mau T, Santi DV, Stroud RM. PMID: 8611496.
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    152. Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2'-deoxyuridine 5'-monophosphate. Biochemistry. 1996 Apr 02; 35(13):3944-9. Costi PM, Liu L, Finer-Moore JS, Stroud RM, Santi DV. PMID: 8672425.
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    153. Interaction of tRNA (uracil-5-)-methyltransferase with NO2Ura-tRNA. Nucleic Acids Res. 1996 Mar 15; 24(6):1059-64. Gu X, Matsuda A, Ivanetich KM, Santi DV. PMID: 8604339.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    154. Expression and characterization of the Trypanosoma cruzi dihydrofolate reductase domain. Mol Biochem Parasitol. 1996 Feb-Mar; 76(1-2):175-85. Reche P, Arrebola R, Santi DV, Gonzalez-Pacanowska D, Ruiz-Perez LM. PMID: 8920005.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    155. Covalent tethering of the dimer interface annuls aggregation in thymidylate synthase. Protein Sci. 1996 Feb; 5(2):270-7. Agarwalla S, Gokhale RS, Santi DV, Balaram P. PMID: 8745405.
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    156. Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase. Protein Eng. 1996 Jan; 9(1):69-75. Finer-Moore JS, Fauman EB, Morse RJ, Santi DV, Stroud RM. PMID: 9053905.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    157. Preparation of equimolar mixtures of peptides by adjustment of activated amino acid concentrations. Methods Enzymol. 1996; 267:247-60. Ivanetich KM, Santi DV. PMID: 8743321.
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    158. Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. Biochemistry. 1995 Dec 19; 34(50):16279-87. Schiffer CA, Clifton IJ, Davisson VJ, Santi DV, Stroud RM. PMID: 8845352.
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    159. Addendum to "Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme" [Mol. Biochem. Parasitol. 72 (1995) 11-22]. Mol Biochem Parasitol. 1995 Dec; 75(1):127. Gamarro F, Yu PL, Zhao J, Edman U, Greene PJ, Santi D. PMID: 8720183.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    160. The synthesis of blocked triplet-phosphoramidites and their use in mutagenesis. Nucleic Acids Res. 1995 Nov 25; 23(22):4677-82. Ono A, Matsuda A, Zhao J, Santi DV. PMID: 8524660.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    161. Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase. Chem Biol. 1995 Sep; 2(9):609-14. Kealey JT, Eckstein J, Santi DV. PMID: 9383465.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    162. Thermodynamic analysis of the binding of 5-fluoro-2'-deoxyuridine 5'-monophosphate to thymidylate synthase over a range of temperatures. Eur J Biochem. 1995 Sep 01; 232(2):641-5. García-Fuentes L, Reche P, López-Mayorga O, Santi DV, González-Pacanowska D, Barón C. PMID: 7556218.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    163. Cloning, expression, purification, and characterization of 2'-deoxyuridylate hydroxymethylase from phage SPO1. Protein Expr Purif. 1995 Aug; 6(4):423-30. Schellenberger U, Livi LL, Santi DV. PMID: 8527927.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    164. Peptide aldehyde inhibitors of hepatitis A virus 3C proteinase. Biochemistry. 1995 Jun 27; 34(25):8172-9. Malcolm BA, Lowe C, Shechosky S, McKay RT, Yang CC, Shah VJ, Simon RJ, Vederas JC, Santi DV. PMID: 7794931.
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    165. Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme. Mol Biochem Parasitol. 1995 Jun; 72(1-2):11-22. Gamarro F, Yu PL, Zhao J, Edman U, Greene PJ, Santi D. PMID: 8538681.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    166. Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines. J Med Chem. 1995 Mar 17; 38(6):967-72. Marlowe CK, Selassie CD, Santi DV. PMID: 7699713.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    167. Stereochemistry of tRNA(m5U54)-methyltransferase catalysis: 19F NMR spectroscopy of an enzyme-FUraRNA covalent complex. Biochemistry. 1995 Feb 28; 34(8):2441-6. Kealey JT, Santi DV. PMID: 7532997.
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    168. The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem. 1995; 64:721-62. Carreras CW, Santi DV. PMID: 7574499.
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    169. Mechanism-based inhibition of thymidylate synthase by 5-(trifluoromethyl)-2'-deoxyuridine 5'-monophosphate. Biochemistry. 1994 Dec 20; 33(50):15086-94. Eckstein JW, Foster PG, Finer-Moore J, Wataya Y, Santi DV. PMID: 7999767.
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    170. Isolation of a covalent steady-state intermediate in glutamate 60 mutants of thymidylate synthase. J Biol Chem. 1994 Dec 16; 269(50):31327-9. Huang W, Santi DV. PMID: 7989294.
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    171. Cloning, expression and characterization of thymidylate synthase from Cryptococcus neoformans. Gene. 1994 Dec 15; 150(2):221-6. Livi LL, Edman U, Schneider GP, Greene PJ, Santi DV. PMID: 7821787.
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    172. Expression of human thymidylate synthase in Escherichia coli. J Biol Chem. 1994 Dec 02; 269(48):30740. Davisson VJ, Sirawaraporn W, Santi DV. PMID: 7982996.
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    173. 5-Fluoro-2'-deoxycytidine 5'-monophosphate is a mechanism-based inhibitor of thymidylate synthase. Biochim Biophys Acta. 1994 Nov 16; 1209(1):89-94. Liu L, Santi DV. PMID: 7947987.
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    174. Expression, purification, and characterization of thymidylate synthase from Lactococcus lactis. Protein Sci. 1994 Jul; 3(7):1114-6. Greene PJ, Yu PL, Zhao J, Schiffer CA, Santi D. PMID: 7920258.
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    175. Cloning and expression of the dihydrofolate reductase-thymidylate synthase gene from Trypanosoma cruzi. Mol Biochem Parasitol. 1994 Jun; 65(2):247-58. Reche P, Arrebola R, Olmo A, Santi DV, Gonzalez-Pacanowska D, Ruiz-Perez LM. PMID: 7969266.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    176. Partial restoration of activity to Lactobacillus casei thymidylate synthase following inactivation by domain deletion. Biochemistry. 1994 May 10; 33(18):5623-9. Schellenberger U, Balaram P, Francis VS, Shoichet BK, Santi DV. PMID: 8180187.
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    177. Identification of biologically active mutants by combinatorial cassette mutagenesis: exclusion of wild-type codon from degenerate codons. Anal Biochem. 1994 May 01; 218(2):454-7. Huang W, Santi DV. PMID: 8074306.
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    178. Heterodimeric thymidylate synthases with C-terminal deletion on one subunit. J Biol Chem. 1994 Apr 29; 269(17):12444-6. Carreras CW, Costi PM, Santi DV. PMID: 8175650.
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    179. Isolation and characterization of a mutant dihydrofolate reductase-thymidylate synthase from methotrexate-resistant Leishmania cells. J Biol Chem. 1994 Apr 08; 269(14):10590-6. Arrebola R, Olmo A, Reche P, Garvey EP, Santi DV, Ruiz-Perez LM, Gonzalez-Pacanowska D. PMID: 8144647.
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    180. High-level expression and rapid purification of tRNA (m5U54)-methyltransferase. Protein Expr Purif. 1994 Apr; 5(2):149-52. Kealey JT, Santi DV. PMID: 8054847.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    181. A C-terminal conformational equilibrium in thymidylate synthase observed by electron paramagnetic resonance spectroscopy. Biochemistry. 1994 Mar 01; 33(8):2071-7. Carreras CW, Naber N, Cooke R, Santi DV. PMID: 8117663.
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    182. In vitro methylation of Escherichia coli 16S rRNA by tRNA (m5U54)-methyltransferase. Biochemistry. 1994 Mar 01; 33(8):2255-61. Gu X, Ofengand J, Santi DV. PMID: 8117682.
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    183. Thermal stabilization of thymidylate synthase by engineering two disulfide bridges across the dimer interface. J Mol Biol. 1994 Jan 07; 235(1):89-94. Gokhale RS, Agarwalla S, Francis VS, Santi DV, Balaram P. PMID: 7904654.
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    184. Enzymatic mechanism of tRNA (m5U54)methyltransferase. Biochimie. 1994; 76(12):1133-42. Kealey JT, Gu X, Santi DV. PMID: 7748948.
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    185. Interaction of thymidylate synthase with pyridoxal 5'-phosphate as studied by UV/visible difference spectroscopy and molecular modeling. Biochemistry. 1993 Nov 09; 32(44):11819-24. Santi DV, Ouyang TM, Tan AK, Gregory DH, Scanlan T, Carreras CW. PMID: 8218253.
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    186. The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Gene synthesis, expression, and anti-folate-resistant mutants. J Biol Chem. 1993 Oct 15; 268(29):21637-44. Sirawaraporn W, Prapunwattana P, Sirawaraporn R, Yuthavong Y, Santi DV. PMID: 8408015.
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    187. Catalytically active cross-species heterodimers of thymidylate synthase. Biochemistry. 1993 Oct 05; 32(39):10283-8. Greene PJ, Maley F, Pedersen-Lane J, Santi DV. PMID: 8399170.
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    188. Asparagine 229 in thymidylate synthase contributes to, but is not essential for, catalysis. Proc Natl Acad Sci U S A. 1993 Sep 15; 90(18):8604-8. Liu L, Santi DV. PMID: 8378336.
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    189. Exclusion of 2'-deoxycytidine 5'-monophosphate by asparagine 229 of thymidylate synthase. Biochemistry. 1993 Sep 14; 32(36):9263-7. Liu L, Santi DV. PMID: 8369294.
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    190. Dihydrofolate reductase from the pathogenic fungus Pneumocystis carinii: catalytic properties and interaction with antifolates. Arch Biochem Biophys. 1993 Sep; 305(2):499-508. Margosiak SA, Appleman JR, Santi DV, Blakley RL. PMID: 8373187.
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    191. Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J Mol Biol. 1993 Aug 20; 232(4):1101-16. Finer-Moore J, Fauman EB, Foster PG, Perry KM, Santi DV, Stroud RM. PMID: 8371269.
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    192. Structures of thymidylate synthase with a C-terminal deletion: role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate. Biochemistry. 1993 Jul 20; 32(28):7116-25. Perry KM, Carreras CW, Chang LC, Santi DV, Stroud RM. PMID: 8343503.
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    193. Cloning, expression, and characterization of Cryptococcus neoformans dihydrofolate reductase. J Biol Chem. 1993 Apr 25; 268(12):8888-92. Sirawaraporn W, Cao M, Santi DV, Edman JC. PMID: 8473332.
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    194. Structure-based discovery of inhibitors of thymidylate synthase. Science. 1993 Mar 05; 259(5100):1445-50. Shoichet BK, Stroud RM, Santi DV, Kuntz ID, Perry KM. PMID: 8451640.
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    195. Mutagenesis, structure and function studies of thymidylate synthase. Nucleic Acids Symp Ser. 1993; (29):103-5. Santi DV. PMID: 8247725.
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    196. Covalent adducts between tRNA (m5U54)-methyltransferase and RNA substrates. Biochemistry. 1992 Oct 27; 31(42):10295-302. Gu X, Santi DV. PMID: 1420148.
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    197. Subunit complementation of thymidylate synthase. Biochemistry. 1992 Oct 27; 31(42):10303-9. Pookanjanatavip M, Yuthavong Y, Greene PJ, Santi DV. PMID: 1420149.
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    198. Purification methods for recombinant Lactobacillus casei thymidylate synthase and mutants: a general, automated procedure. Protein Expr Purif. 1992 Oct; 3(5):380-5. Kealey JT, Santi DV. PMID: 1333860.
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    199. Thymidylate synthase with a C-terminal deletion catalyzes partial reactions but is unable to catalyze thymidylate formation. Biochemistry. 1992 Jul 07; 31(26):6038-44. Carreras CW, Climie SC, Santi DV. PMID: 1627546.
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    200. Complete replacement set of amino acids at the C-terminus of thymidylate synthase: quantitative structure-activity relationship of mutants of an enzyme. Biochemistry. 1992 Jul 07; 31(26):6032-8. Climie SC, Carreras CW, Santi DV. PMID: 1627545.
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    201. Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase. Biochemistry. 1992 Jun 09; 31(22):5100-4. Liu L, Santi DV. PMID: 1606134.
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    202. Reversible dissociation and unfolding of the dimeric protein thymidylate synthase. Protein Sci. 1992 Jun; 1(6):796-800. Perry KM, Pookanjanatavip M, Zhao J, Santi DV, Stroud RM. PMID: 1304920.
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    203. Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4505-9. Zuckermann RN, Kerr JM, Siani MA, Banville SC, Santi DV. PMID: 1584783.
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    204. 5,6-dihydropyrimidine adducts in the reactions and interactions of pyrimidines with proteins. Prog Nucleic Acid Res Mol Biol. 1992; 42:127-56. Ivanetich KM, Santi DV. PMID: 1574586.
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    205. A rapid method for determination of endoproteinase substrate specificity: specificity of the 3C proteinase from hepatitis A virus. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11510-4. Petithory JR, Masiarz FR, Kirsch JF, Santi DV, Malcolm BA. PMID: 1662396.
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    206. Stereochemistry of methyl transfer catalyzed by tRNA (m5U54)-methyltransferase--evidence for a single displacement mechanism. Nucleic Acids Res. 1991 Dec 11; 19(23):6465-8. Kealey JT, Lee S, Floss HG, Santi DV. PMID: 1754383.
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    207. Identification of the catalytic nucleophile of tRNA (m5U54)methyltransferase. Biochemistry. 1991 Oct 08; 30(40):9724-8. Kealey JT, Santi DV. PMID: 1911760.
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    208. Purification and properties of recombinant Pneumocystis carinii dihydrofolate reductase. Protein Expr Purif. 1991 Oct-Dec; 2(5-6):313-6. Sirawaraporn W, Edman JC, Santi DV. PMID: 1821803.
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    209. Purification and characterization of recombinant Pneumocystis carinii thymidylate synthase. Protein Expr Purif. 1991 Oct-Dec; 2(5-6):350-4. Santi DV, Edman U, Minkin S, Greene PJ. PMID: 1821808.
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    210. Automated purification of synthetic oligonucleotides. Biotechniques. 1991 Jun; 10(6):704-8. Ivanetich KM, Akiyama J, Santi DV, Reschenberg M. PMID: 1878202.
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    211. Crystallization of human thymidylate synthase. J Mol Biol. 1991 May 20; 219(2):161-3. Schiffer CA, Davisson VJ, Santi DV, Stroud RM. PMID: 2038053.
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    212. The T-arm of tRNA is a substrate for tRNA (m5U54)-methyltransferase. Biochemistry. 1991 Mar 26; 30(12):2999-3002. Gu XR, Santi DV. PMID: 2007136.
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    213. Stereochemical studies of the C-methylation of deoxycytidine catalyzed by HhaI methylase and the N-methylation of deoxyadenosine catalyzed by EcoRI methylase. Arch Biochem Biophys. 1991 Feb 01; 284(2):264-9. Ho DK, Wu JC, Santi DV, Floss HG. PMID: 1989510.
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    214. Purification and characterization of dihydrofolate reductase from wild-type and trimethoprim-resistant Mycobacterium smegmatis. Exp Parasitol. 1991 Feb; 72(2):184-90. Sirawaraporn W, Sirawaraporn R, Chanpongsri A, Jacobs WR, Santi DV. PMID: 2009922.
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    215. Affinity chromatography of Escherichia coli (m5U54)-methyltransferase on tRNA-agarose. Protein Expr Purif. 1991 Feb; 2(1):66-8. Gu X, Santi DV. PMID: 1821774.
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    216. Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum. Biochemistry. 1990 Dec 04; 29(48):10779-85. Sirawaraporn W, Sirawaraporn R, Cowman AF, Yuthavong Y, Santi DV. PMID: 2176883.
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    217. Saturation site-directed mutagenesis of thymidylate synthase. J Biol Chem. 1990 Nov 05; 265(31):18776-9. Climie S, Ruiz-Perez L, Gonzalez-Pacanowska D, Prapunwattana P, Cho SW, Stroud R, Santi DV. PMID: 2229040.
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    218. Characterization of the human immunodeficiency virus type-1 reverse transcriptase enzyme produced in yeast. Biochem Biophys Res Commun. 1990 Sep 14; 171(2):589-95. Bathurst IC, Moen LK, Lujan MA, Gibson HL, Feucht PH, Pichuantes S, Craik CS, Santi DV, Barr PJ. PMID: 1698361.
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    219. High-level expression of Escherichia coli tRNA (m5U54)-methyltransferase. DNA Cell Biol. 1990 May; 9(4):273-8. Gu XR, Santi DV. PMID: 2190591.
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    220. Site-directed mutagenesis of arginine 179 of thymidylate synthase. A nonessential substrate-binding residue. J Biol Chem. 1990 Apr 25; 265(12):6770-5. Santi DV, Pinter K, Kealey J, Davisson VJ. PMID: 2182628.
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    221. Thymidylate synthase-dihydrofolate reductase in protozoa. Exp Parasitol. 1990 Apr; 70(3):367-71. Ivanetich KM, Santi DV. PMID: 2178951.
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    222. Bifunctional thymidylate synthase-dihydrofolate reductase in protozoa. FASEB J. 1990 Apr 01; 4(6):1591-7. Ivanetich KM, Santi DV. PMID: 2180768.
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    223. Chemical synthesis of the thymidylate synthase gene. Proc Natl Acad Sci U S A. 1990 Jan; 87(2):633-7. Climie S, Santi DV. PMID: 2153960.
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    224. On the inhibition of deoxycytidylate hydroxymethylase by 5-fluoro-2'-deoxycytidine 5'-monophosphate. Arch Biochem Biophys. 1989 Nov 15; 275(1):11-5. Subramaniam R, Wang Y, Mathews CK, Santi DV. PMID: 2684015.
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    225. Stereochemical modeling of disulfide bridges. Criteria for introduction into proteins by site-directed mutagenesis. Protein Eng. 1989 Nov; 3(2):95-103. Sowdhamini R, Srinivasan N, Shoichet B, Santi DV, Ramakrishnan C, Balaram P. PMID: 2594728.
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    226. Isolation and expression of the Pneumocystis carinii dihydrofolate reductase gene. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8625-9. Edman JC, Edman U, Cao M, Lundgren B, Kovacs JA, Santi DV. PMID: 2682653.
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    227. Isolation and expression of the Pneumocystis carinii thymidylate synthase gene. Proc Natl Acad Sci U S A. 1989 Sep; 86(17):6503-7. Edman U, Edman JC, Lundgren B, Santi DV. PMID: 2671992.
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    228. Expression of human thymidylate synthase in Escherichia coli. J Biol Chem. 1989 Jun 05; 264(16):9145-8. Davisson VJ, Sirawaraporn W, Santi DV. PMID: 2656695.
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    229. Migration properties of circular DNAs using orthogonal-field-alternation gel electrophoresis. Electrophoresis. 1989 May-Jun; 10(5-6):283-90. Hightower RC, Santi DV. PMID: 2670543.
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    230. Analysis of amplified DNAs from drug-resistant Leishmania by orthogonal-field-alternation gel electrophoresis. The effect of size and topology on mobility. J Biol Chem. 1989 Feb 15; 264(5):2979-84. Hightower RC, Bliska JB, Cozzarelli NR, Santi DV. PMID: 2536730.
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    231. Ribosomal RNA genes of Pneumocystis carinii. J Protozool. 1989 Jan-Feb; 36(1):18S-20S. Edman JC, Kovacs JA, Masur H, Santi DV, Elwood HJ, Sogin ML. PMID: 2540326.
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    232. Biomedical science and the third world. Under the volcano. Recent studies on thymidylate synthase. Ann N Y Acad Sci. 1989; 569:201-10. Ivanetich KM, Santi DV. PMID: 2698088.
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    233. [Biocytin13]dynorphin A 1-13 amide: a potential probe for the kappa-opioid receptor. Pharm Res. 1988 Dec; 5(12):790-4. Hochhaus G, Patthy A, Schwietert R, Santi DV, Sadée W. PMID: 2907785.
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    234. Extrachromosomal elements in the lower eukaryote Leishmania. J Biol Chem. 1988 Nov 15; 263(32):16970-6. Hightower RC, Ruiz-Perez LM, Wong ML, Santi DV. PMID: 3182826.
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    235. Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines. Mol Biochem Parasitol. 1988 Oct; 31(1):79-85. Sirawaraporn W, Sertsrivanich R, Booth RG, Hansch C, Neal RA, Santi DV. PMID: 3185614.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    236. Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the fungi. Nature. 1988 Aug 11; 334(6182):519-22. Edman JC, Kovacs JA, Masur H, Santi DV, Elwood HJ, Sogin ML. PMID: 2970013.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    237. 5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase. Biochemistry. 1988 Jul 12; 27(14):5204-10. Osterman DG, DePillis GD, Wu JC, Matsuda A, Santi DV. PMID: 3167042.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    238. On the mechanism of DNA-adenine methylase. J Biol Chem. 1988 Jun 05; 263(16):7461-4. Pogolotti AL, Ono A, Subramaniam R, Santi DV. PMID: 3259576.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    239. Heterologous expression of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania major. Biochemistry. 1988 May 17; 27(10):3776-84. Grumont R, Sirawaraporn W, Santi DV. PMID: 2841973.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    240. Cloning, sequencing, and expression of the Lactobacillus casei thymidylate synthase gene. DNA. 1988 May; 7(4):235-41. Pinter K, Davisson VJ, Santi DV. PMID: 2840247.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    241. High level expression and purification of HhaI methyltransferase. Nucleic Acids Res. 1988 Jan 25; 16(2):703-17. Wu JC, Santi DV. PMID: 3340551.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    242. Thymidylate synthase and fluorouracil. Adv Exp Med Biol. 1988; 244:113-24. Ivanetich KM, Santi DV. PMID: 3150251.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    243. Kinetics and thermodynamics of the interaction of 5-fluoro-2'-deoxyuridylate with thymidylate synthase. Biochemistry. 1987 Dec 29; 26(26):8606-13. Santi DV, McHenry CS, Raines RT, Ivanetich KM. PMID: 3126806.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    244. Catalytic mechanism and inhibition of tRNA (uracil-5-)methyltransferase: evidence for covalent catalysis. Biochemistry. 1987 Dec 29; 26(26):8599-606. Santi DV, Hardy LW. PMID: 3327525.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    245. Plasmid migration using orthogonal-field-alternation gel electrophoresis. Nucleic Acids Res. 1987 Oct 26; 15(20):8387-98. Hightower RC, Metge DW, Santi DV. PMID: 2823228.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    246. Electron microscopy of amplified DNA forms in antifolate-resistant Leishmania. J Biol Chem. 1987 Oct 25; 262(30):14618-24. Hightower RC, Wong ML, Ruiz-Perez L, Santi DV. PMID: 2822697.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    247. Folylpolyglutamates in Leishmania major. Biochem Biophys Res Commun. 1987 Aug 14; 146(3):1089-92. Santi DV, Nolan P, Shane B. PMID: 3619916.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    248. A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction. J Biol Chem. 1987 Jul 05; 262(19):9068-74. Garvey EP, Santi DV. PMID: 3597407.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    249. Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth. J Med Chem. 1987 Jul; 30(7):1218-24. Booth RG, Selassie CD, Hansch C, Santi DV. PMID: 3599028.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    250. Kinetic and catalytic mechanism of HhaI methyltransferase. J Biol Chem. 1987 Apr 05; 262(10):4778-86. Wu JC, Santi DV. PMID: 3558369.
      View in: PubMed   Mentions: 150     Fields:    Translation:Cells
    251. Atomic structure of thymidylate synthase: target for rational drug design. Science. 1987 Jan 23; 235(4787):448-55. Hardy LW, Finer-Moore JS, Montfort WR, Jones MO, Santi DV, Stroud RM. PMID: 3099389.
      View in: PubMed   Mentions: 70     Fields:    Translation:Cells
    252. Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins. Proc Natl Acad Sci U S A. 1986 Aug; 83(15):5387-91. Grumont R, Washtien WL, Caput D, Santi DV. PMID: 3461439.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    253. Stable amplified DNA in drug-resistant Leishmania exists as extrachromosomal circles. Science. 1986 Aug 01; 233(4763):535-40. Garvey EP, Santi DV. PMID: 3726545.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    254. Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase. J Med Chem. 1986 Apr; 29(4):478-82. Pogolotti AL, Danenberg PV, Santi DV. PMID: 3754285.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    255. The mechanism and structure of thymidylate synthetase. Nucleic Acids Symp Ser. 1986; (17):125-6. Santi DV. PMID: 3562257.
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    256. Limited proteolysis of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica. Proc Natl Acad Sci U S A. 1985 Nov; 82(21):7188-92. Garvey EP, Santi DV. PMID: 3903747.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    257. Selection and properties of Leishmania tropica resistant to 10-propargyl-5,8-dideazafolate, an inhibitor of thymidylate synthetase. Mol Biochem Parasitol. 1985 Oct; 17(1):79-91. Garvey EP, Coderre JA, Santi DV. PMID: 4058489.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    258. Inosine analogs as anti-leishmanial agents. Pharm Res. 1985 Sep; 2(5):217-20. Rainey P, Nolan PA, Townsend LB, Robins RK, Fox JJ, Secrist Iii JA, Santi DV. PMID: 24272839.
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    259. DNA amplification in antifolate-resistant Leishmania. The thymidylate synthase-dihydrofolate reductase gene and abundant mRNAs. J Biol Chem. 1985 Jul 05; 260(13):7809-12. Washtien WL, Grumont R, Santi DV. PMID: 2409075.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    260. Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica. Biochemistry. 1985 Jan 29; 24(3):678-86. Meek TD, Garvey EP, Santi DV. PMID: 3922404.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    261. On the mechanism and inhibition of DNA cytosine methyltransferases. Prog Clin Biol Res. 1985; 198:119-29. Wu JC, Santi DV. PMID: 4070306.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    262. Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci U S A. 1984 Nov; 81(22):6993-7. Santi DV, Norment A, Garrett CE. PMID: 6209710.
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    263. Pneumocystis carinii pneumonia treated with alpha-difluoromethylornithine. A prospective study among patients with the acquired immunodeficiency syndrome. West J Med. 1984 Nov; 141(5):613-23. Golden JA, Sjoerdsma A, Santi DV. PMID: 6440364.
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    264. Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase. J Med Chem. 1984 Oct; 27(10):1259-62. Goldstein S, Pogolotti AL, Garvey EP, Santi DV. PMID: 6434741.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    265. Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization. Cell. 1984 Sep; 38(2):431-9. Beverley SM, Coderre JA, Santi DV, Schimke RT. PMID: 6467372.
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    266. Experimental combination chemotherapy with thymidylate synthetase and ribonucleotide reductase inhibitors. Pharm Res. 1984 Jul; 1(4):181-3. Kobayashi S, Hoshino T, Santi DV. PMID: 24277289.
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    267. Formycin B resistance in Leishmania. Biochem Pharmacol. 1984 Apr 15; 33(8):1374-7. Rainey P, Santi DV. PMID: 6712743.
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    268. A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa. Mol Biochem Parasitol. 1984 Apr; 11:257-65. Garrett CE, Coderre JA, Meek TD, Garvey EP, Claman DM, Beverley SM, Santi DV. PMID: 6749182.
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    269. On the mechanism of the acid-catalyzed hydrolysis of uridine to uracil. Evidence for 6-hydroxy-5,6-dihydrouridine intermediates. J Biol Chem. 1984 Feb 25; 259(4):2429-34. Prior JJ, Santi DV. PMID: 6546573.
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    270. Adducts across the 5,6-double bond of pyrimidines. The mechanism of dehydration of 1-substituted uracil photohydrates. J Biol Chem. 1984 Feb 25; 259(4):2422-8. Prior JJ, Maley J, Santi DV. PMID: 6698974.
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    271. Thymidylate synthetase-catalyzed conversions of E-5-(2-bromovinyl)-2'-deoxyuridylate. J Biol Chem. 1983 Nov 25; 258(22):13627-31. Barr PJ, Oppenheimer NJ, Santi DV. PMID: 6417131.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    272. Mechanism of action of 2',5-difluoro-1-arabinosyluracil. J Med Chem. 1983 Aug; 26(8):1149-52. Coderre JA, Santi DV, Matsuda A, Watanabe KA, Fox JJ. PMID: 6876083.
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    273. Metabolism of formycin B by Leishmania amastigotes in vitro. Comparative metabolism in infected and uninfected human macrophages. J Exp Med. 1983 Jul 01; 158(1):252-7. Berman JD, Rainey P, Santi DV. PMID: 6190980.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    274. On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs. Cell. 1983 May; 33(1):9-10. Santi DV, Garrett CE, Barr PJ. PMID: 6205762.
      View in: PubMed   Mentions: 123     Fields:    Translation:Cells
    275. Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proc Natl Acad Sci U S A. 1983 Apr; 80(8):2132-6. Coderre JA, Beverley SM, Schimke RT, Santi DV. PMID: 6572966.
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    276. Reaction of 5-ethynyl-2'-deoxyuridylate with thiols and thymidylate synthetase. Biochemistry. 1983 Mar 29; 22(7):1696-703. Barr PJ, Robins MJ, Santi DV. PMID: 6405782.
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    277. The metabolism and cytotoxic effects of Formycin B in Trypanosoma cruzi. Biochem Pharmacol. 1983 Feb 15; 32(4):749-52. Rainey P, Garrett CE, Santi DV. PMID: 6338883.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    278. Metabolism and mechanism of action of formycin B in Leishmania. Proc Natl Acad Sci U S A. 1983 Jan; 80(1):288-92. Rainey P, Santi DV. PMID: 6572004.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    279. Secondary alpha-hydrogen isotope effects on the interaction of 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate with thymidylate synthetase. Biochemistry. 1982 Dec 21; 21(26):6703-9. Bruice TW, Santi DV. PMID: 7159556.
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    280. High-pressure liquid chromatography--ultraviolet analysis of intracellular nucleotides. Anal Biochem. 1982 Nov 01; 126(2):335-45. Pogolotti AL, Santi DV. PMID: 7158770.
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    281. Metabolism and mechanism of action of 5-fluorodeoxycytidine. Proc Natl Acad Sci U S A. 1982 Nov; 79(21):6419-23. Newman EM, Santi DV. PMID: 6959127.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    282. Mechanism of action of 5-nitro-2'-deoxyuridine. J Med Chem. 1982 Oct; 25(10):1252-5. Washtien WL, Santi DV. PMID: 6183429.
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    283. Inhibition of thymidylate synthetase by 5-alkynyl-2'-deoxyuridylates. J Med Chem. 1981 Dec; 24(12):1385-8. Barr PJ, Nolan PA, Santi DV, Robins MJ. PMID: 6796687.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    284. Interaction of 1-(5-phospho-beta-D-arabinofuranosyl)-5-substituted-uracils with thymidylate synthetase: mechanism-based inhibition by 1-(5-phospho-beta-D-arabinosyl)-5-fluorouracil. J Med Chem. 1981 Oct; 24(10):1161-5. Nakayama C, Wataya Y, Santi DV, Saneyoshi M, Ueda T. PMID: 7328576.
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    285. Methods for the complete analysis of 5-fluorouracil metabolites in cell extracts. Anal Biochem. 1981 Oct; 117(1):178-86. Pogolotti AL, Nolan PA, Santi DV. PMID: 6459042.
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    286. Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines. J Med Chem. 1980 Aug; 23(8):962-4. Nakayama C, Wataya Y, Meyer RB, Santi DV, Saneyoshi M, Ueda T. PMID: 7401121.
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    287. Interaction of thymidylate synthetase with 5-nitro-2'-deoxyuridylate. J Biol Chem. 1980 Jun 25; 255(12):5538-44. Wataya Y, Matsuda A, Santi DV. PMID: 6769917.
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    288. On the mechanism of 2'-deoxyuridylate hydroxymethylase. Biochemistry. 1980 Apr 01; 19(7):1271-5. Kunitani MG, Santi DV. PMID: 6770896.
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    289. Perspective on the design and biochemical pharmacology of inhibitors of thymidylate synthetase. J Med Chem. 1980 Feb; 23(2):103-11. Santi DV. PMID: 6987403.
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    290. Use of alpha-secondary isotope effects in nucleophile-promoted reactions of pyrimidine derivatives; evidence for transient 5,6-dihydropyrimidine intermediates. Nucleic Acids Symp Ser. 1980; (8):s55-8. Wataya Y, Kawada R, Itadani A, Hayatsu H, Bruice TW, Garrett C, Matsuda A, Santi DV. PMID: 7255197.
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    291. Use of secondary alpha-hydrogen isotope effects in reactions of pyrimidine nucleoside/nucleotide metabolism: thymidylate synthetase. Methods Enzymol. 1980; 64:125-35. Bruice TW, Garrett C, Wataya Y, Santi DV. PMID: 6768958.
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    292. Simultaneous measurement of charging levels of multiple aminoacyl-tRNAs. Anal Biochem. 1979 Nov 01; 99(2):372-8. Smith RA, Santi DV. PMID: 391096.
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    293. A rapid and sensitive high pressure liquid chromatography assay for deoxyribonucleoside triphosphates in cell extracts. Anal Biochem. 1979 Nov 01; 99(2):268-73. Garrett C, Santi DV. PMID: 517739.
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    294. In vivo inhibitors of Escherichia coli phenylalanyl-tRNA synthetase. J Med Chem. 1979 Oct; 22(10):1260-3. Santi DV, Cunnion SO, Anderson RT, Webster RW. PMID: 390149.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    295. Assay of intracellular free and macromolecular-bound metabolites of 5-fluorodeoxyuridine and 5-fluorouracil. Cancer Res. 1979 Sep; 39(9):3397-404. Washtien WL, Santi DV. PMID: 157805.
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    296. Thymidylate synthetase catalyzed exchange of tritiumfrom [5-3H]-2'-deoxyuridylate for protons of water. Biochemistry. 1979 Jun 26; 18(13):2794-8. Pogolotti AL, Weill C, Santi DV. PMID: 113030.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    297. Thymidylate synthetase. Catalysis of dehalogenation of 5-bromo- and 5-iodo-2'-deoxyuridylate. Biochemistry. 1979 Jun 26; 18(13):2798-804. Garrett C, Wataya Y, Santi DV. PMID: 476052.
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    298. trans-5-(3,3,3-Trifluoro-1-propenyl-)-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase. J Med Chem. 1979 Apr; 22(4):339-40. Wataya Y, Matsuda A, Santi DV, Bergstrom DE, Ruth JL. PMID: 430474.
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    299. Approaches for purification of the glucocorticoid receptor. Monogr Endocrinol. 1979; 12:109-22. Santi DV, Washtien W, Pogolotti AL. PMID: 492170.
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    300. 5-Nitro-2'-deoxyuridylate: a mechanism-based inhibitor of thymidylate synthetase. Biochem Biophys Res Commun. 1978 Oct 16; 84(3):654-9. Matsuda A, Wataya Y, Santi DV. PMID: 102324.
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    301. Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate. Proc Natl Acad Sci U S A. 1978 Feb; 75(2):980-3. Ullman B, Lee M, Martin DW, Santi DV. PMID: 147465.
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    302. Cytotoxicity of 5-nitro-2'-deoxyuridine by in vivo inhibition of thymidylate synthetase. Biochem Pharmacol. 1978; 27(22):2663-6. Washtien W, Matsuda A, Wataya Y, Santi DV. PMID: 215163.
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    303. Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship. J Med Chem. 1977 Nov; 20(11):1469-73. Wataya Y, Santi DV, Hansch C. PMID: 410930.
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    304. A secondary isotope effect in the cysteine-Promoted dehalogenation of 5-bromo-2'-deoxyuridine. evidence for transient 5,6-dihydropyrimidine intermediates. J Am Chem Soc. 1977 Jun 22; 99(13):4534-6. Wataya Y, Santi DV. PMID: 864127.
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    305. Separation of 5-substituted 2'-deoxyuridines and deoxyuridylates by high-pressure anion-exchange liquid chromatography. Anal Biochem. 1977 May 01; 79(1-2):602-4. Garrett C, Pogolotti AL, Santi DV. PMID: 869199.
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    306. Active-site labeling of thymidylate synthetase with 5-fluoro-2'-deoxyuridylate. Methods Enzymol. 1977; 46:307-12. Wataya Y, Santi DV. PMID: 909420.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    307. Phenylalanyl transfer ribonucleic acid synthetase from rat liver. Analysis of phenylalanine and adenosine 5'-triphosphate binding sites and comparison to the enzyme from Escherichia coli. J Med Chem. 1976 Nov; 19(11):1276-9. Santi DV, Webster RW. PMID: 794471.
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    308. Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli B. Potent inhibition by analogues of N-benzyl-2-phenylethylamine. J Med Chem. 1976 Nov; 19(11):1270-5. Anderson RT, Santi DV. PMID: 794470.
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    309. Thymidylate synthetase: fluorine-19 nmr characterization of the active site peptide covalently bound to 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate. Biochem Biophys Res Commun. 1976 Sep 20; 72(2):404-10. James TL, Pogolotti AL, Ivanetich KM, Wataya Y, Lam SS, Santi DV. PMID: 825116.
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    310. On the structure of the cofactor in the complex formed with thymidylate synthetase, 5,10-methylenetetrahy-drofolate and 5-fluoro-2'-deoxyuridylate. Biochim Biophys Acta. 1976 Jun 07; 438(1):324-31. Santi DV, Penã VA, Lam SS. PMID: 938684.
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    311. Thymidylate synthetase: studies on peptide containing covalently bound 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate. Biochem Biophys Res Commun. 1976 Jun 07; 70(3):972-8. Pogolotti AL, Ivanetich KM, Sommer H, Santi DV. PMID: 820346.
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    312. Thymidylate synthetase catalyzed dehalogenation of 5-bromo-and 5-iodo-2'-deoxyuridylate. Biochem Biophys Res Commun. 1975 Nov 17; 67(2):818-23. Wataya Y, Santi DV. PMID: 812499.
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    313. The role of polyamines in the aminoacyl transfer ribonucleic acid synthetase reactions. Demonstration of the requirement for magnesium ion and a secondary stimulatory effect of spermine. J Biol Chem. 1975 May 25; 250(10):3874-7. Santi DV, Webster RW. PMID: 165187.
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    314. Inhibition of phenylalanyl-tRNA synthetase by aromatic guanidines and amidines. J Med Chem. 1975 May; 18(5):528-30. Danenberg PV, Santi DV. PMID: 1097688.
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    315. A filter technique for measurement of steroid-receptor binding. Methods Enzymol. 1975; 36:234-9. Baxter JD, Santi DV, Rousseau GG. PMID: 162980.
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    316. Purification and amino acid analysis of an active site peptide from thymidylate synthetase containing covalently bound 5-fluoro-2'-deoxyuridylate and methylenetetrahydrofolate. Biochem Biophys Res Commun. 1974 Apr 08; 57(3):689-95. Sommer H, Santi DV. PMID: 4275130.
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    317. A sulfhydryl group is not the covalent catalyst in the thymidylate synthetase reaction. Biochem Biophys Res Commun. 1974 Mar 15; 57(1):204-8. McHenry CS, Santi DV. PMID: 4275163.
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    318. A deae-cellulose filter disk assay for aminoacyl-tRNA. Anal Biochem. 1974 Mar; 58(1):175-82. Santi DV, Anderson RT. PMID: 4596570.
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    319. Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry. 1974 Jan 29; 13(3):471-81. Santi DV, McHenry CS, Sommer H. PMID: 4203910.
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    320. Model studies of the thymidylate synthetase reaction. Nucleophilic displacement of 5-p-nitrophenoxymethyluracils. Biochemistry. 1974 Jan 29; 13(3):456-66. Pogolotti AL, Santi DV. PMID: 4810063.
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    321. Macromolecular affinity labeling agents. Reaction of N-bromoacetylisoleucyl transfer ribonucleic acid with isoleucyl transfer ribonucleic acid synthetase. Biochemistry. 1974 Jan 29; 13(3):481-5. Santi DV, Cunnion SO. PMID: 4589311.
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    322. A filter assay for thymidylate synthetase using 5-fluoro-2'-deoxyuridylate as an active site titrant. Biochemistry. 1974 Jan 29; 13(3):467-70. Santi DV, McHenry CS, Perriard ER. PMID: 4358948.
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    323. Kinetics of aminoacyl-tRNA synthetases catalyzed ATP-PPi exchange. Methods Enzymol. 1974; 29:620-7. Santi DV, Webster RW, Cleland WW. PMID: 4368856.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    324. Peptidyl-tRNA analogs as affinity labeling agents. Methods Enzymol. 1974; 29:695-706. Santi DV, Cunnion SO. PMID: 4604890.
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    325. Hydrolysis of hydroxybenzotrifluorides and fluorinated uracil derivatives. A general mechanism for carbon-fluorine bond labilization. J Med Chem. 1973 Oct; 16(10):1079-84. Sakai TT, Santi DV. PMID: 4749467.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    326. A filter assay for steroid hormone receptors. Biochemistry. 1973 Jun 19; 12(13):2412-6. Santi DV, Sibley CH, Perriard ER, Tomkins GM, Baxter JD. PMID: 4350952.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    327. Model studies of thymidylate synthetase. Intramolecular catalysis of 5-hydrogen exchange and 5-hydroxymethylation of 1-substituted uracils. Biochemistry. 1973 Jun 19; 12(13):2416-24. Santi DV, Brewer CF. PMID: 4709938.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    328. A simple method for quantitating ligands covalently bound to agarose beads. Anal Biochem. 1973 Apr; 52(2):363-8. Failla D, Santi DV. PMID: 4698834.
      View in: PubMed   Mentions: 5     Fields:    
    329. Affinity labeling of isoleucyl-tRNA synthetase with N-bromoacetylisoleucyl-tRNA. Biochem Biophys Res Commun. 1973 Mar 17; 51(2):370-5. Santi DV, Marchant W, Yarus M. PMID: 4571405.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    330. Tyrosyl transfer ribonucleic acid synthetase from Escherichia coli B. Analysis of tyrosine and adenosine 5'-triphosphate binding sites. J Med Chem. 1973 Mar; 16(3):273-80. Santi DV, Pena VA. PMID: 4581950.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    331. 5-Fluoro-2'-deoxyuridylate: covalent complex with thymidylate synthetase. Proc Natl Acad Sci U S A. 1972 Jul; 69(7):1855-7. Santi DV, McHenry CS. PMID: 4505665.
      View in: PubMed   Mentions: 44     Fields:    Translation:Cells
    332. Irreversible inhibition of thymidylate synthetase by 5-formyl-2'-deoxyuridylic acid. Biochem Biophys Res Commun. 1972 Feb 16; 46(3):1320-5. Santi DV, Sakai TT. PMID: 4622223.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    333. Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the adenosine triphosphate binding site. Biochemistry. 1971 Dec 07; 10(25):4821-4. Santi DV, Danenberg PV, Montgomery KA. PMID: 4334587.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    334. Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Reaction parameters and order of substrate addition. Biochemistry. 1971 Dec 07; 10(25):4804-12. Santi DV, Danenberg PV, Satterly P. PMID: 4334585.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    335. Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the phenylalanine binding site. Biochemistry. 1971 Dec 07; 10(25):4813-20. Santi DV, Danenberg PV. PMID: 4334586.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    336. Thymidylate synthetase. Model studies of inhibition by 5-trifluoromethyl-2'-deoxyuridylic acid. Biochemistry. 1971 Sep 14; 10(19):3598-607. Santi DV, Sakai TT. PMID: 5146573.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    337. Purification of the araC protein. Proc Natl Acad Sci U S A. 1971 Sep; 68(9):2145-8. Wilcox G, Clemetson KJ, Santi DV, Englesberg E. PMID: 4943786.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    338. Order of substrate binding to tyrosyl-tRNA synthetase of Escherichia coli B. FEBS Lett. 1971 Mar 05; 13(3):157-160. Santi DV, Peña VA. PMID: 11945656.
      View in: PubMed   Mentions: 4     Fields:    
    339. Inhibition of thymidylate synthetase by 5-formyl- and 5-hydroxymethyl-2'-deoxyuridylate. Biochem Biophys Res Commun. 1971 Mar 05; 42(5):813-7. Santi DV, Sakai TT. PMID: 4929928.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    340. Model studies of thymidylate synthetase. Neighboring-group facilitation of electrophilic substitution reactions of uracil furanosides. J Am Chem Soc. 1968 Oct 23; 90(22):6236-8. Santi DV, Brewer CF. PMID: 5696276.
      View in: PubMed   Mentions: 4     Fields:    
    341. Nonclassical antimetabolites. XXV. Inhibitors of thymidine kinase. I. A new spectrophotometric assay. Inhibition by nucleoside derivatives. J Med Chem. 1966 Jan; 9(1):66-72. Baker BR, Schwan TJ, Santi DV. PMID: 4225176.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    342. Analogs of tetrahydrofolic acid. XXVII. Hydrophobic bonding to dihydrofolic reductase by 2-amino-4,6-disubstituted-5-alkylpyrimidines and 1-alkyl-4,6-diamino-1,2-dihydro-s-triazines. J Pharm Sci. 1965 Oct; 54(10):1415-24. Baker BR, Beng-Thong Ho, Santi DV. PMID: 5883214.
      View in: PubMed   Mentions: 1     Fields:    
    343. Analogs of tetrahydrofolic acid XXIV. Further observations on the mode of pyrimidyl binding to dihydrofolic reductase and thymidylate synthetase by the 2-amino-5-(3-anilinopropyl)-6-methyl-4-pyrimidinol type of inhibitor. J Pharm Sci. 1965 Sep; 54(9):1252-7. Baker BR, Santi DV. PMID: 5881214.
      View in: PubMed   Mentions: 14     Fields:    
    344. ANALOGS OF TETRAHYDROFOLIC ACID. XIV. FACILE SYNTHETIC ROUTE TO THE 2-AMINO-5-(3-ANILINOPROPYL)-6-METHYL-4-PYRIMIDINOL TYPE OF FOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE INHIBITOR. J Pharm Sci. 1964 Nov; 53:1317-25. BAKER BR, SANTI DV, SHAPIRO HS. PMID: 14253585.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    345. ANALOGS OF TETRAHYDROFOLIC ACID. X. SYNTHETIC AND ENZYMIC STUDIES ON THE CONTRIBUTION OF THE P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES. J Med Chem. 1964 Jan; 7:24-30. BAKER BR, SANTI DV, ALMAULA PI, WERKEISER WC. PMID: 14186020.
      View in: PubMed   Mentions: 4     Fields:    
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