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Anil Parsram Bidkar, PhD

Photo of Anil Parsram Bidkar, PhD
Title(s)Assistant Researcher, Radiology
SchoolSchool of Medicine
Address185 Berry Street Bldg B, #340-2
San Francisco CA 94107
PronounsHe/Him/His
ORCID ORCID Icon0000-0003-1249-1081 Additional info
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    Collapse Biography 
    Collapse education and training
    University of California, San Francisco, San Francisco,, San Francisco, California, United StatesPostdoctoral Fellow09/2025Radiopharmaceutical Sciences
    Indian Institute of Technology Guwahati, Assam, IndiaPh.D.12/2019Cancer Targeted Drug Delivery
    National Institute of Pharmaceutical Education and Research, Guwahati, Assam, IndiaMS07/2014Pharmaceutical Biotechnology
    AES's College of Pharmacy, Pune, IndiaBS08/2012Pharmaceutical Sciences
    Collapse awards and honors
    SNMMI Mars Shot-Prostate Cancer Foundation2026  - 2029Young Investigator Award
    UCSF Pancreas Center Program2026  - 2027Mentored Scientist Award in Pancreas Cancer
    Society of Nuclear Medicine and Molecular Imaging2026  - 2026SNMMI Future Leaders Academy Graduate
    Helen Diller Family Comprehensive Cancer Center (HDFCCC), UCSF2025  - 2026Mesothelioma Pilot Award
    Society of Nuclear Medicine and Molecular Imaging2025  - 2025Ones to Watch recognition
    National Cancer Institute, National Institutes of Health2025  - 2030K99/R00 Pathway to Independence Award
    Society of Nuclear Medicine and Molecular Imaging2025  - 2025Young Investigator Award
    UCSF Radiology and Biomedical Imaging2025  - 2025The Bruce Hasegawa Memorial Lecturer Award
    Helen Diller Family ComprehensiveCancer Center (HDFCCC), UCSF2024  - 2025Awarded Prostate Cancer Research Pilot Grant
    CDMRP, Department of Defense, Prostate Cancer Research Program2023  - 2025Early Investigator Award, CDMRP, Prostate Cancer Research Program

    Collapse Overview 
    Collapse overview
    I am a radiopharmaceutical scientist in the Department of Radiology and Biomedical Imaging at UCSF, developing targeted molecular imaging and radioligand therapy strategies for cancer. My research focuses on antibody-based and ligand-directed theranostics that enable both noninvasive PET imaging and targeted delivery of therapeutic radionuclides, with an emphasis on alpha- and beta-emitting radiometals. I integrate radiochemistry, quantitative imaging, and translational tumor model development to evaluate new agents targeting clinically relevant cancer antigens, including CD46, PSMA, STEAP1, DLL3, and ALPPL2, across prostate cancer, pancreatic cancer, and other solid tumors. A major goal of my work is to understand and overcome mechanisms of resistance to radioligand therapy, and to develop rational combination strategies incorporating antibody-drug conjugates and other targeted therapeutics. In parallel, I am developing binder discovery platforms, including phage display-based approaches, to identify novel high-affinity targeting ligands that expand the scope of actionable cancer antigens for next-generation theranostic development.

    Collapse Research 
    Collapse research activities and funding
    ALPPL2 targeted molecular imaging and therapy of pancreatic cancer
    UCSF Pancreas Center Program Project 7032894Jan 1, 2026 - Dec 31, 2026
    Role: PI
    Development of ALPPL2 targeted molecular imaging and therapy for mesothelioma
    HDFCCC Mesothelioma RFA 2025 Project 7032691Aug 1, 2025 - Jul 31, 2026
    Role: PI
    Enhancing prostate cancer treatment outcomes with combined radioimmunotherapy and antibody drug conjugates
    National Institute of Health K99CA304511Jul 7, 2025 - Jul 7, 2030
    Role: Principal Investigator
    Actinium-225/MMAE Dual-Loaded Antibody Drug Conjugate for Prostate Cancer Targeted Therapy
    UCSF Helen Diller Family Comprehensive Cancer Center, Prostate Cancer Program Project 7031918Jan 1, 2024 - Jun 28, 2025
    Role: Principal Investigator
    Synergistic combination treatment of prostate cancer using CD46-targeted antibody-drug conjugate and radioimmunotherapy
    CDMRP, Department of Defense, Prostate Cancer Research Program E01 HT94252310139Mar 1, 2023 - Feb 28, 2025
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Synergistic treatment of prostate cancer and multiple myeloma using CD46-targeted radioimmunotherapy-antibody drug conjugates. Clin Cancer Res. 2026 Jan 22. Bidkar AP, Bidlingmaier S, Wadhwa A, Mayne E, Raveendran A, Naik S, Xue C, Basak M, Bobba KN, Patiño-Escobar B, Greenland N, Camara Serrano JA, Steri V, Chou J, Wiita A, He J, Wilson DM, Aggarwal R, VanBrocklin HF, Seo Y, Liu B, Flavell RR. PMID: 41569419.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Effective imaging and treatment of Acute Myeloid Leukemia with radiotheranostics targeting the activated conformation of integrin-βeta2. Res Sq. 2025 Oct 29. Wadhwa A, Johnson H, Bobba KN, Bidkar AP, Mayne E, Rampersaud S, Mandal K, Barpanda A, Prudhvi S, Kang AS, Greenland N, Balitzer D, Peter R, Raveendran A, Naik S, Basak M, Kasap C, Werner J, López-Álvarez M, Lee SH, Steri V, Adams JJ, Sidhu SS, Wilson DM, Seo Y, VanBrocklin HF, Logan AC, Wiita AP, Flavell RR. PMID: 41282197; PMCID: PMC12636732.
      View in: PubMed   Mentions:
    3. Effective imaging and treatment of Acute Myeloid Leukemia with radiotheranostics targeting the activated conformation of integrin-βeta2. bioRxiv. 2025 Aug 25. Wadhwa A, Johnson H, Bobba KN, Bidkar AP, Mayne E, Rampersaud S, Mandal K, Barpanda A, Prudhvi S, Kang AS, Greenland N, Balitzer D, Peter R, Raveendran A, Naik S, Basak M, Kasap C, Huebner J, Alvarez ML, Lee S, Steri V, Adams JJ, Sidhu SS, Wilson DM, Seo Y, VanBrocklin HF, Logan AC, Wiita AP, Flavell RR. PMID: 40909732; PMCID: PMC12407801.
      View in: PubMed   Mentions:
    4. Evaluation of 134Ce/134La-PSMA-617 for PET Imaging and Auger Electron Therapy of Prostate Cancer. J Nucl Med. 2025 Aug 01; 66(8):1252-1257. Bobba KN, Wadhwa A, Bidkar AP, Raveendran A, Garcia L, Greenland N, Wilson DM, Seo Y, VanBrocklin HF, Flavell RR. PMID: 40506238; PMCID: PMC12320565.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Effective Treatment of Disseminated Prostate Cancer Using CD46-Targeted 225Ac Therapy. Clin Cancer Res. 2025 Jul 15; 31(14):2963-2977. Bidkar AP, Peter R, Wadhwa A, Bobba KN, Bidlingmaier S, Meher N, Chou J, Greenland N, Dasari C, Naik S, Raveendran A, Basak M, Camara Serrano JA, Steri V, Kogan S, Oskowitz A, He J, Wilson DM, Aggarwal R, Sriram R, VanBrocklin HF, Seo Y, Liu B, Flavell RR. PMID: 39945595; PMCID: PMC12260511.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Modulation of Donor in Purely Organic Triplet Harvesting AIE-TADF Photosensitizer for Image-guided Photodynamic Therapy. Small. 2025 Feb; 21(7):e2409533. Barman D, Rajamalli P, Bidkar AP, Sarmah T, Ghosh SS, Zysman-Colman E, Iyer PK. PMID: 39780649.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. PET Imaging Using 89Zr-Labeled StarPEG Nanocarriers Reveals Heterogeneous Enhanced Permeability and Retention in Prostate Cancer. Mol Cancer Ther. 2025 Jan 02; 24(1):141-151. Meher N, Bidkar AP, Wadhwa A, Bobba KN, Dhrona S, Dasari C, Mu C, Fong COY, Cámara JA, Ali U, Basak M, Bulkley D, Steri V, Fontaine SD, Zhu J, Oskowitz A, Aggarwal RR, Sriram R, Chou J, Wilson DM, Seo Y, Santi DV, Ashley GW, VanBrocklin HF, Flavell RR. PMID: 39331510; PMCID: PMC11694059.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. 3D small-scale dosimetry and tumor control of 225Ac radiopharmaceuticals for prostate cancer. Sci Rep. 2024 08 27; 14(1):19938. Peter R, Bidkar AP, Bobba KN, Zerefa L, Dasari C, Meher N, Wadhwa A, Oskowitz A, Liu B, Miller BW, Vetter K, Flavell RR, Seo Y. PMID: 39198676; PMCID: PMC11358493.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. A Technique to Quantify Very Low Activities in Regions of Interest With a Collimatorless Detector. IEEE Trans Med Imaging. 2024 08; 43(8):2745-2757. Caravaca J, Bobba KN, Du S, Peter R, Gullberg GT, Bidkar AP, Flavell RR, Seo Y. PMID: 38478457; PMCID: PMC11293990.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. Prostate-Specific Membrane Antigen Targeted StarPEG Nanocarrier for Imaging and Therapy of Prostate Cancer. Adv Healthc Mater. 2024 07; 13(19):e2304618. Meher N, Ashley GW, Bobba KN, Wadhwa A, Bidkar AP, Dasari C, Mu C, Sankaranarayanan RA, Serrano JAC, Raveendran A, Bulkley DP, Aggarwal R, Greenland NY, Oskowitz A, Wilson DM, Seo Y, Santi DV, VanBrocklin HF, Flavell RR. PMID: 38700450; PMCID: PMC11281871.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Actinium-225 targeted alpha particle therapy for prostate cancer. Theranostics. 2024; 14(7):2969-2992. Bidkar AP, Zerefa L, Yadav S, VanBrocklin HF, Flavell RR. PMID: 38773983; PMCID: PMC11103494.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    12. CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma. Clin Cancer Res. 2024 03 01; 30(5):1009-1021. Wadhwa A, Wang S, Patiño-Escobar B, Bidkar AP, Bobba KN, Chan E, Meher N, Bidlingmaier S, Su Y, Dhrona S, Geng H, Sarin V, VanBrocklin HF, Wilson DM, He J, Zhang L, Steri V, Wong SW, Martin TG, Seo Y, Liu B, Wiita AP, Flavell RR. PMID: 38109209; PMCID: PMC10905524.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    13. Development of CD46 targeted alpha theranostics in prostate cancer using 134Ce/225Ac-Macropa-PEG4-YS5. Theranostics. 2024; 14(4):1344-1360. Bobba KN, Bidkar AP, Wadhwa A, Meher N, Drona S, Sorlin AM, Bidlingmaier S, Zhang L, Wilson DM, Chan E, Greenland NY, Aggarwal R, VanBrocklin HF, He J, Chou J, Seo Y, Liu B, Flavell RR. PMID: 38389832; PMCID: PMC10879874.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    14. Highly efficient color-tunable organic co-crystals unveiling polymorphism, isomerism, delayed fluorescence for optical waveguides and cell-imaging. Nat Commun. 2023 Oct 20; 14(1):6648. Barman D, Annadhasan M, Bidkar AP, Rajamalli P, Barman D, Ghosh SS, Chandrasekar R, Iyer PK. PMID: 37863932; PMCID: PMC10589249.
      View in: PubMed   Mentions: 8     Fields:    
    15. Coded aperture and Compton imaging for the development of 225 Ac-based radiopharmaceuticals. Med Phys. 2023 Oct; 50(10):6454-6468. Frame E, Bobba K, Gunter D, Mihailescu L, Bidkar A, Flavell R, Vetter K. PMID: 37672346.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    16. Evaluation of 134Ce/134La as a PET Imaging Theranostic Pair for 225Ac α-Radiotherapeutics. J Nucl Med. 2023 07; 64(7):1076-1082. Bobba KN, Bidkar AP, Meher N, Fong C, Wadhwa A, Dhrona S, Sorlin A, Bidlingmaier S, Shuere B, He J, Wilson DM, Liu B, Seo Y, VanBrocklin HF, Flavell RR. PMID: 37201957; PMCID: PMC10315697.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    17. Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy. Clin Cancer Res. 2023 05 15; 29(10):1916-1928. Bidkar AP, Wang S, Bobba KN, Chan E, Bidlingmaier S, Egusa EA, Peter R, Ali U, Meher N, Wadhwa A, Dhrona S, Dasari C, Beckford-Vera D, Su Y, Tang R, Zhang L, He J, Wilson DM, Aggarwal R, VanBrocklin HF, Seo Y, Chou J, Liu B, Flavell RR. PMID: 36917693; PMCID: PMC10183825.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    18. CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment. J Exp Clin Cancer Res. 2023 Mar 11; 42(1):61. Li J, Huang T, Hua J, Wang Q, Su Y, Chen P, Bidlingmaier S, Li A, Xie Z, Bidkar AP, Shen S, Shi W, Seo Y, Flavell RR, Gioeli D, Dreicer R, Li H, Liu B, He J. PMID: 36906664; PMCID: PMC10007843.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    19. Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer. Cancer Res. 2023 01 18; 83(2):301-315. Chou J, Egusa EA, Wang S, Badura ML, Lee F, Bidkar AP, Zhu J, Shenoy T, Trepka K, Robinson TM, Steri V, Huang J, Wang Y, Small EJ, Chan E, Stohr BA, Ashworth A, Delafontaine B, Rottey S, Cooke KS, Hashemi Sadraei N, Yu B, Salvati M, Bailis JM, Feng FY, Flavell RR, Aggarwal R. PMID: 36351060; PMCID: PMC10263373.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    20. Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers. ACS Appl Mater Interfaces. 2022 Nov 16; 14(45):50569-50582. Meher N, Ashley GW, Bidkar AP, Dhrona S, Fong C, Fontaine SD, Beckford Vera DR, Wilson DM, Seo Y, Santi DV, VanBrocklin HF, Flavell RR. PMID: 36318757; PMCID: PMC9673064.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    21. Synthesis and Preliminary Biological Assessment of Carborane-Loaded Theranostic Nanoparticles to Target Prostate-Specific Membrane Antigen. ACS Appl Mater Interfaces. 2021 Nov 24; 13(46):54739-54752. Meher N, Seo K, Wang S, Bidkar AP, Fogarty M, Dhrona S, Huang X, Tang R, Blaha C, Evans MJ, Raleigh DR, Jun YW, VanBrocklin HF, Desai TA, Wilson DM, Ozawa T, Flavell RR. PMID: 34752058; PMCID: PMC12490465.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. Developing membrane-derived nanocarriers for ex vivo therapy of homologous breast cancer cells. Nanomedicine (Lond). 2021 09; 16(21):1843-1856. Saha M, Bidkar AP, Ghosh SS. PMID: 34369819.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    23. A conformational tweak for enhanced cellular internalization, photobleaching resistance and prolonged imaging efficacy. Chem Commun (Camb). 2020 Nov 26; 56(94):14861-14864. Meher N, Bidkar AP, Barman D, Ghosh SS, Iyer PK. PMID: 33174881.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Effect of Secondary Structure and Side Chain Length of Hydrophobic Amino Acid Residues on the Antimicrobial Activity and Toxicity of 14-Residue-Long de novo AMPs. ChemMedChem. 2021 01 19; 16(2):355-367. Pandit G, Chowdhury N, Abdul Mohid S, Bidkar AP, Bhunia A, Chatterjee S. PMID: 33026188.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    25. Peptide Hydrogels as Platforms for Sustained Release of Antimicrobial and Antitumor Drugs and Proteins. ACS Appl Bio Mater. 2020 Sep 21; 3(9):6251-6262. Roy K, Pandit G, Chetia M, Sarkar AK, Chowdhuri S, Bidkar AP, Chatterjee S. PMID: 35021757.
      View in: PubMed   Mentions: 7     Fields:    
    26. Nerve growth factor from Indian Russell's viper venom (RVV-NGFa) shows high affinity binding to TrkA receptor expressed in breast cancer cells: Application of fluorescence labeled RVV-NGFa in the clinical diagnosis of breast cancer. Biochimie. 2020 Sep; 176:31-44. Islam T, Majumder M, Bidkar A, Ghosh SS, Mukhopadhyay R, Utkin Y, Mukherjee AK. PMID: 32585227.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. Rationally designed antimicrobial peptides: Insight into the mechanism of eleven residue peptides against microbial infections. Biochim Biophys Acta Biomembr. 2020 04 01; 1862(4):183177. Pandit G, Biswas K, Ghosh S, Debnath S, Bidkar AP, Satpati P, Bhunia A, Chatterjee S. PMID: 31954105.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    28. Red Blood Cell-Membrane-Coated Poly(Lactic-co-glycolic Acid) Nanoparticles for Enhanced Chemo- and Hypoxia-Activated Therapy. ACS Appl Bio Mater. 2019 Sep 16; 2(9):4077-4086. Bidkar AP, Sanpui P, Ghosh SS. PMID: 35021341.
      View in: PubMed   Mentions: 14     Fields:    
    29. Deciphering Hydrodynamic and Drug-Resistant Behaviors of Metastatic EMT Breast Cancer Cells Moving in a Constricted Microcapillary. J Clin Med. 2019 Aug 09; 8(8). Nath B, Bidkar AP, Kumar V, Dalal A, Jolly MK, Ghosh SS, Biswas G. PMID: 31404980; PMCID: PMC6722803.
      View in: PubMed   Mentions: 7  
    30. Combination Therapy with MAPK-Pathway-Specific Inhibitor and Folic-Acid-Receptor-Targeted Selenium Nanoparticles Induces Synergistic Antiproliferative Response in BRAF Mutant Cancer Cells. ACS Biomater Sci Eng. 2019 May 13; 5(5):2222-2234. Bidkar AP, Sanpui P, Ghosh SS. PMID: 33405774.
      View in: PubMed   Mentions: 4     Fields:    
    31. Insights into the Mechanism of Antimicrobial Activity of Seven-Residue Peptides. J Med Chem. 2018 09 13; 61(17):7614-7629. Pandit G, Ilyas H, Ghosh S, Bidkar AP, Mohid SA, Bhunia A, Satpati P, Chatterjee S. PMID: 30070835.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. Efficient induction of apoptosis in cancer cells by paclitaxel-loaded selenium nanoparticles. Nanomedicine (Lond). 2017 Nov; 12(21):2641-2651. Bidkar AP, Sanpui P, Ghosh SS. PMID: 29043926.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    33. Studying in vitro phagocytosis of apoptotic cancer cells by recombinant GMCSF-treated RAW 264.7 macrophages. Int J Biol Macromol. 2017 Sep; 102:1138-1145. Selvarajan V, Bidkar AP, Shome R, Banerjee A, Chaubey N, Ghosh SS, Sanpui P. PMID: 28476594.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    34. Protein folding and misfolding in the neurodegenerative disorders: a review. Rev Neurol (Paris). 2014 Mar; 170(3):151-61. Bolshette NB, Thakur KK, Bidkar AP, Trandafir C, Kumar P, Gogoi R. PMID: 24613386.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
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