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David Bulkley, PhD

Title(s)RESEARCHER, Biochemistry And Biophysics
SchoolSchool of Medicine
Phone415-514-9708
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    Collapse Research 
    Collapse Research Activities and Funding
    Cryo-EM structures of a serotonin gated ion channel
    NIH F32GM113360Feb 1, 2015 - Jan 31, 2017
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Alexander Myasnikov, Shawn Zheng, David Bulkley, Yifan Cheng, David Agard. Abstract OR-16: High Resolution Cryo-Electron Microscopy and New Direct Electron Detector from Gatan - K3. International Journal of Biomedicine. 2019 Jun 30; 9(Suppl_1):s12-s12.
      View in: Publisher Site
    2. Zhang Y, Bulkley DP, Xin Y, Roberts KJ, Asarnow DE, Sharma A, Myers BR, Cho W, Cheng Y, Beachy PA. Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched. Cell. 2018 11 15; 175(5):1352-1364.e14. PMID: 30415841.
      View in: PubMed
    3. Alexander Myasnikov, Shawn Zheng, David Bulkley, Yifan Cheng, David Agard. K3 - A First Look at The New Direct Electron Detection Camera from Gatan Company. Microscopy and Microanalysis. 2018 Aug 1; 24(S1):890-891.
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    4. Palovcak E, Wang F, Zheng SQ, Yu Z, Li S, Betegon M, Bulkley D, Agard DA, Cheng Y. A simple and robust procedure for preparing graphene-oxide cryo-EM grids. J Struct Biol. 2018 10; 204(1):80-84. PMID: 30017701.
      View in: PubMed
    5. Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkley D, Yu Y, Tang J, Flockerzi V, Cao Y, Cao E, Chen XZ. Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. Nat Commun. 2018 06 13; 9(1):2302. PMID: 29899465.
      View in: PubMed
    6. Eugene Palovcak, David Bulkley, Shawn Zheng, Feng Wang, David Agard, Yifan Cheng. Graphene-Oxide Substrate for High-Resolution Single Particle Cryo-EM. Biophysical Journal. 2018 Feb 1; 114(3):11a.
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    7. Peng Jin, David Bulkley, Yanmeng Guo, Wei Zhang, Zhenhao Guo, Walter Huynh, Shenping Wu, Shan Meltzer, Tong Cheng, Lily Yeh Jan, Yuh-Nung Jan, Yifan Cheng. Cryo-EM structure of the Mechanotransduction Channel NOMPC. Biophysical Journal. 2018 Feb 1; 114(3):22a.
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    8. Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 12 21; 552(7685):426-429. PMID: 29236684.
      View in: PubMed
    9. Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y. Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Nature. 2017 07 06; 547(7661):118-122. PMID: 28658211.
      View in: PubMed
    10. Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E. The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell. 2016 Oct 20; 167(3):763-773.e11. PMID: 27768895.
      View in: PubMed
    11. Lin J, Gagnon MG, Bulkley D, Steitz TA. Conformational changes of elongation factor G on the ribosome during tRNA translocation. Cell. 2015 Jan 15; 160(1-2):219-27. PMID: 25594181.
      View in: PubMed
    12. Polikanov YS, Osterman IA, Szal T, Tashlitsky VN, Serebryakova MV, Kusochek P, Bulkley D, Malanicheva IA, Efimenko TA, Efremenkova OV, Konevega AL, Shaw KJ, Bogdanov AA, Rodnina MV, Dontsova OA, Mankin AS, Steitz TA, Sergiev PV. Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Mol Cell. 2014 Nov 20; 56(4):531-40. PMID: 25306919.
      View in: PubMed
    13. Gagnon MG, Lin J, Bulkley D, Steitz TA. Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome. Science. 2014 Aug 08; 345(6197):684-7. PMID: 25104389.
      View in: PubMed
    14. Gagnon MG, Seetharaman SV, Bulkley D, Steitz TA. Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome. Science. 2012 Mar 16; 335(6074):1370-2. PMID: 22422986.
      View in: PubMed
    15. Thomas A. Steitz, Gregor Blaha, C. Axel Innis, Robin Evans Stanley, David Bulkley. Structural Studies of the Functional Complexes of the 50S and 70S Ribosome, a Major Antibiotic Target. Macromolecular Crystallography. 2012 Jan 1; 135-148.
      View in: Publisher Site
    16. C. Axel Innis, Gregor Blaha, David Bulkley, Thomas A. Steitz. Structural studies of complexes of the 70S ribosome. Ribosomes. 2011 Jan 1; 31-43.
      View in: Publisher Site
    17. Bulkley D, Innis CA, Blaha G, Steitz TA. Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17158-63. PMID: 20876130.
      View in: PubMed
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