Janet Finer-Moore, PhD

Title(s)RES-FY, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th Street, #S412B
San Francisco CA 94158
Phone415-476-3937
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. Nat Struct Mol Biol. 2023 03; 30(3):296-308. Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM. PMID: 36782050; PMCID: PMC10312659.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    2. Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13. bioRxiv. 2023 Jan 28. Kim SK, Dickinson MS, Finer-Moore J, Guan Z, Kaake RM, Echeverria I, Chen J, Pulido EH, Sali A, Krogan NJ, Rosenberg OS, Stroud RM. PMID: 36747776; PMCID: PMC9900942.
      View in: PubMed   Mentions:
    3. Diversity of function and mechanism in a family of organic anion transporters. Curr Opin Struct Biol. 2022 08; 75:102399. Li F, Eriksen J, Finer-Moore J, Stroud RM, Edwards RH. PMID: 35660266; PMCID: PMC9884543.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. Biochemistry. 2021 04 27; 60(16):1243-1247. Kholodar SA, Finer-Moore JS, Swiderek K, Arafet K, Moliner V, Stroud RM, Kohen A. PMID: 33829766; PMCID: PMC10627423.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Ion transport and regulation in a synaptic vesicle glutamate transporter. Science. 2020 05 22; 368(6493):893-897. Li F, Eriksen J, Finer-Moore J, Chang R, Nguyen P, Bowen A, Myasnikov A, Yu Z, Bulkley D, Cheng Y, Edwards RH, Stroud RM. PMID: 32439795; PMCID: PMC7388591.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    6. Diversity in kinetics correlated with structure in nano body-stabilized LacY. PLoS One. 2020; 15(5):e0232846. Kumar H, Finer-Moore J, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM. PMID: 32380514; PMCID: PMC7205474.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    7. Crystal Structure of a ligand-bound LacY-Nanobody Complex. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):8769-8774. Kumar H, Finer-Moore JS, Jiang X, Smirnova I, Kasho V, Pardon E, Steyaert J, Kaback HR, Stroud RM. PMID: 30108145; PMCID: PMC6126719.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    8. A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer. Biochemistry. 2018 05 15; 57(19):2786-2795. Finer-Moore JS, Lee TT, Stroud RM. PMID: 29717875; PMCID: PMC6242337.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    9. Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides. Proc Natl Acad Sci U S A. 2016 Apr 26; 113(17):4711-6. Kapoor K, Finer-Moore JS, Pedersen BP, Caboni L, Waight A, Hillig RC, Bringmann P, Heisler I, Müller T, Siebeneicher H, Stroud RM. PMID: 27078104; PMCID: PMC4855560.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    10. Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. J Mol Biol. 2015 Dec 04; 427(24):3862-76. Finer-Moore J, Czudnochowski N, O'Connell JD, Wang AL, Stroud RM. PMID: 26470919; PMCID: PMC4663122.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    11. Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9004-9. Kumar H, Finer-Moore JS, Kaback HR, Stroud RM. PMID: 26157133; PMCID: PMC4517220.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    12. Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell. 2015 Apr 23; 161(3):501-512. Rosenberg OS, Dovala D, Li X, Connolly L, Bendebury A, Finer-Moore J, Holton J, Cheng Y, Stroud RM, Cox JS. PMID: 25865481; PMCID: PMC4409929.
      View in: PubMed   Mentions: 61     Fields:    Translation:Cells
    13. Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides. J Med Chem. 2015 Jan 22; 58(2):1012-8. Tochowicz A, Santucci M, Saxena P, Guaitoli G, Trande M, Finer-Moore J, Stroud RM, Costi MP. PMID: 25427005; PMCID: PMC8346289.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    14. Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10404-10. Lohse MB, Rosenberg OS, Cox JS, Stroud RM, Finer-Moore JS, Johnson AD. PMID: 24994900; PMCID: PMC4115540.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    15. Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3865-70. Monk BC, Tomasiak TM, Keniya MV, Huschmann FU, Tyndall JD, O'Connell JD, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM. PMID: 24613931; PMCID: PMC3956205.
      View in: PubMed   Mentions: 101     Fields:    Translation:Cells
    16. Structure of sugar-bound LacY. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1784-8. Kumar H, Kasho V, Smirnova I, Finer-Moore JS, Kaback HR, Stroud RM. PMID: 24453216; PMCID: PMC3918835.
      View in: PubMed   Mentions: 66     Fields:    Translation:Cells
    17. The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res. 2014 Feb; 42(3):2037-48. Czudnochowski N, Ashley GW, Santi DV, Alian A, Finer-Moore J, Stroud RM. PMID: 24214967; PMCID: PMC3919597.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    18. Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11; 56(13):5446-55. Tochowicz A, Dalziel S, Eidam O, O'Connell JD, Griner S, Finer-Moore JS, Stroud RM. PMID: 23710599; PMCID: PMC3880649.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    19. In human pseudouridine synthase 1 (hPus1), a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA, consistent with their different target selectivities. J Mol Biol. 2013 Oct 23; 425(20):3875-87. Czudnochowski N, Wang AL, Finer-Moore J, Stroud RM. PMID: 23707380; PMCID: PMC3900414.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    20. Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J Am Chem Soc. 2013 May 22; 135(20):7583-92. Wang Z, Sapienza PJ, Abeysinghe T, Luzum C, Lee AL, Finer-Moore JS, Stroud RM, Kohen A. PMID: 23611499; PMCID: PMC3674108.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    21. Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. J Med Chem. 2012 Nov 26; 55(22):10272-6. Carosati E, Tochowicz A, Marverti G, Guaitoli G, Benedetti P, Ferrari S, Stroud RM, Finer-Moore J, Luciani R, Farina D, Cruciani G, Costi MP. PMID: 23075414.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    22. A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase. J Am Chem Soc. 2012 Oct 24; 134(42):17722-30. Wang Z, Abeysinghe T, Finer-Moore JS, Stroud RM, Kohen A. PMID: 23034004; PMCID: PMC3490427.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    23. LpxI structures reveal how a lipid A precursor is synthesized. Nat Struct Mol Biol. 2012 Nov; 19(11):1132-8. Metzger LE, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM. PMID: 23042606; PMCID: PMC3562136.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    24. EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13450-5. Rosenberg OS, Dovey C, Tempesta M, Robbins RA, Finer-Moore JS, Stroud RM, Cox JS. PMID: 21795602; PMCID: PMC3158157.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    25. Structural and functional basis for RNA cleavage by Ire1. BMC Biol. 2011 Jul 06; 9:47. Korennykh AV, Korostelev AA, Egea PF, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. PMID: 21729333; PMCID: PMC3149027.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    26. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol. 2011 Jul 06; 9:48. Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Stroud RM, Zhang C, Shokat KM, Walter P. PMID: 21729334; PMCID: PMC3158555.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    27. Structural context shapes the aquaporin selectivity filter. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17164-9. Savage DF, O'Connell JD, Miercke LJ, Finer-Moore J, Stroud RM. PMID: 20855585; PMCID: PMC2951435.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    28. Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome. J Mol Biol. 2009 May 15; 388(4):785-800. Alian A, DeGiovanni A, Griner SL, Finer-Moore JS, Stroud RM. PMID: 19298824; PMCID: PMC2796871.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    29. The unfolded protein response signals through high-order assembly of Ire1. Nature. 2009 Feb 05; 457(7230):687-93. Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P. PMID: 19079236; PMCID: PMC2846394.
      View in: PubMed   Mentions: 338     Fields:    Translation:AnimalsCells
    30. Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6876-81. Alian A, Lee TT, Griner SL, Stroud RM, Finer-Moore J. PMID: 18451029; PMCID: PMC2383949.
      View in: PubMed   Mentions: 51     Fields:    Translation:Cells
    31. The crystal structure of E. coli rRNA pseudouridine synthase RluE. J Mol Biol. 2007 Apr 13; 367(5):1459-70. Pan H, Ho JD, Stroud RM, Finer-Moore J. PMID: 17320904; PMCID: PMC1876706.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    32. Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective. J Biol Chem. 2006 Dec 22; 281(51):38969-73. Hur S, Stroud RM, Finer-Moore J. PMID: 17085441.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    33. The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261. Biochemistry. 2006 Jun 20; 45(24):7415-28. Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM. PMID: 16768437; PMCID: PMC2556892.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    34. On the mechanism of sensing unfolded protein in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):18773-84. Credle JJ, Finer-Moore JS, Papa FR, Stroud RM, Walter P. PMID: 16365312; PMCID: PMC1316886.
      View in: PubMed   Mentions: 252     Fields:    Translation:HumansAnimalsCells
    35. The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Acta Crystallogr D Biol Crystallogr. 2005 Oct; 61(Pt 10):1320-34. Finer-Moore JS, Anderson AC, O'Neil RH, Costi MP, Ferrari S, Krucinski J, Stroud RM. PMID: 16204883.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    36. Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12648-53. Pan H, Agarwalla S, Moustakas DT, Finer-Moore J, Stroud RM. PMID: 14566049; PMCID: PMC240672.
      View in: PubMed   Mentions: 61     Fields:    Translation:Cells
    37. The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase. Protein Eng. 2003 Aug; 16(8):607-14. Gonzalez-Pacanowska D, Ruiz-Perez LM, Carreras-Gómez MA, Costi MP, Stroud RM, Finer-Moore J, Santi DV. PMID: 12968078.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    38. The only active mutant of thymidylate synthase D169, a residue far from the site of methyl transfer, demonstrates the exquisite nature of enzyme specificity. Protein Eng. 2003 Mar; 16(3):229-40. Birdsall DL, Finer-Moore J, Stroud RM. PMID: 12702803.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    39. Conformational dynamics along an enzymatic reaction pathway: thymidylate synthase, "the movie". Biochemistry. 2003 Jan 21; 42(2):239-47. Stroud RM, Finer-Moore JS. PMID: 12525150.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    40. Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: thymidylate synthase mutagenesis, function, and structure. Biochemistry. 2003 Jan 21; 42(2):248-56. Finer-Moore JS, Santi DV, Stroud RM. PMID: 12525151.
      View in: PubMed   Mentions: 55     Fields:    Translation:Cells
    41. Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. Biochemistry. 2002 Jun 04; 41(22):7021-9. Fritz TA, Liu L, Finer-Moore JS, Stroud RM. PMID: 12033935.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
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