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Donna Peehl, PhD

Title(s)Professor, Radiology
SchoolSchool of Medicine
Phone650-725-5531
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Postdoctoral FellowOncogenes
    University of California, Irvine Postdoctoral FellowTumor Suppressors
    University of Colorado, Boulder Doctor of PhilosophyMolecular, Cellular and Developmental Biology
    Stanford University, California UndergraduateBiology
    Collapse Awards and Honors
    SWIU/SBUR 2016Award for Excellence in Urologic Research

    Collapse Overview 
    Collapse Overview
    Donna Peehl, PhD, is an adjunct Professor in the Body Research Interest Group in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. She received her undergraduate degree in biology at Stanford University in California and completed her PhD in Molecular, Cellular and Developmental Biology at the University of Colorado in Boulder. During postdoctoral fellowship research at the University of California in Irvine and San Francisco, she investigated tumor suppressor genes and oncogenes in cancer. Prior to joining UCSF, Dr. Peehl became Professor Emerita at Stanford University, California, after 35 years as a basic scientist in the Department of Urology. She is widely recognized for her work in developing realistic and representative preclinical cell and tissue models of prostate and kidney cancer.

    Dr. Peehl’s current studies focus on developing novel therapeutics for prostate and kidney cancer. In collaboration with investigators at UCSF and Stanford, she is testing novel inhibitors of the tyrosine kinase AXL and of the scaffold protein, IQGAP, for their anti-cancer activity in her patient-derived models of kidney cancer. Another project uses tissue slice cultures to investigate cancer-associated glycosylation as a novel immunotherapy target. Under the auspices of a new NIH U01 grant, Dr. Peehl is collaborating with Dr. John Kurhanewicz and others at UCSF to compare metabolism of four types of kidney cancer preclinical models by hyperpolarized molecular imaging.

    Dr. Peehl has been the recipient of numerous grants from the NIH and Department of Defense (DoD) Prostate Cancer Research Program, and has received awards from the Prostate Cancer Foundation (formerly CaP CURE) to support her research. She has served as chair or scientist reviewer for many NIH and grant review panels and has reviewed or served on the editorial board for a large number of scientific journals. Her peer-reviews include over 200 articles and publications.

    Expertise:
    Urology

    Specialty:
    Prostate cancer, kidney cancer, molecular and cellular biology

    Professional Interests:
    Patient-derived xenografts, tissue slice cultures, primary cultures, spheroid cultures, preclinical drug testing, biomarkers, metabolism, cancer biology, translational science

    Collapse Research 
    Collapse Research Activities and Funding
    Metabolic imaging comparisons of patient-derived models of renal cell carcinoma
    NIH/NCI U01CA217456Sep 1, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    A Serum Marker for Aggressive Prostate Cancer
    NIH/NCI R01CA121460Aug 28, 2006 - Jul 31, 2013
    Role: Principal Investigator
    GROWTH FACTORS IN THE PROSTATE: AN IN VITRO MODEL
    NIH/NIDDK R01DK047551Sep 30, 1993 - Aug 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Bancroft Brown J, Sriram R, VanCriekinge M, Delos Santos R, Sun J, Delos Santos J, Tabatabai ZL, Shinohara K, Nguyen H, Peehl DM, Kurhanewicz J. NMR quantification of lactate production and efflux and glutamate fractional enrichment in living human prostate biopsies cultured with [1,6-13 C2 ]glucose. Magn Reson Med. 2019 Aug; 82(2):566-576. PMID: 30924180.
      View in: PubMed
    2. Abrouk N, Oronsky B, Caroen S, Ning S, Knox S, Peehl D. A note on improved statistical approaches to account for pseudoprogression. Cancer Chemother Pharmacol. 2018 03; 81(3):621-626. PMID: 29404682.
      View in: PubMed
    3. Chen X, Nagai Y, Zhu Z, Ruan H, Peehl DM, Greene MI, Zhang H. A spliced form of CD44 expresses the unique glycan that is recognized by the prostate cancer specific antibody F77. Oncotarget. 2018 Jan 09; 9(3):3631-3640. PMID: 29423071.
      View in: PubMed
    4. Spiciarich DR, Nolley R, Maund SL, Purcell SC, Herschel J, Iavarone AT, Peehl DM, Bertozzi CR. Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics. Angew Chem Int Ed Engl. 2017 07 24; 56(31):8992-8997. PMID: 28649697.
      View in: PubMed
    5. Zhao H, Ning S, Nolley R, Scicinski J, Oronsky B, Knox SJ, Peehl DM. The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry. Clin Epigenetics. 2017; 9:4. PMID: 28149332.
      View in: PubMed
    6. Oronsky B, Paulmurugan R, Foygel K, Scicinski J, Knox SJ, Peehl D, Zhao H, Ning S, Cabrales P, Summers TA, Reid TR, Fitch WL, Kim MM, Trepel JB, Lee MJ, Kesari S, Abrouk ND, Day RM, Oronsky A, Ray CM, Carter CA. RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials. Expert Opin Investig Drugs. 2017 01; 26(1):109-119. PMID: 27935336.
      View in: PubMed
    7. Zhao H, Nolley R, Chan AMW, Rankin EB, Peehl DM. Cabozantinib inhibits tumor growth and metastasis of a patient-derived xenograft model of papillary renal cell carcinoma with MET mutation. Cancer Biol Ther. 2017 Nov 02; 18(11):863-871. PMID: 27715452.
      View in: PubMed
    8. Türkcan S, Naczynski DJ, Nolley R, Sasportas LS, Peehl DM, Pratx G. Endoscopic detection of cancer with lensless radioluminescence imaging and machine vision. Sci Rep. 2016 08 01; 6:30737. PMID: 27477912.
      View in: PubMed
    9. Saeed K, Rahkama V, Eldfors S, Bychkov D, Mpindi JP, Yadav B, Paavolainen L, Aittokallio T, Heckman C, Wennerberg K, Peehl DM, Horvath P, Mirtti T, Rannikko A, Kallioniemi O, Östling P, Af Hällström TM. Comprehensive Drug Testing of Patient-derived Conditionally Reprogrammed Cells from Castration-resistant Prostate Cancer. Eur Urol. 2017 03; 71(3):319-327. PMID: 27160946.
      View in: PubMed
    10. Oronsky B, Scicinski J, Ning S, Peehl D, Oronsky A, Cabrales P, Bednarski M, Knox S. Rockets, radiosensitizers, and RRx-001: an origin story part I. Discov Med. 2016 03; 21(115):173-80. PMID: 27115167.
      View in: PubMed
    11. Sriram R, Van Criekinge M, DeLos Santos J, Keshari KR, Wilson DM, Peehl D, Kurhanewicz J, Wang ZJ. Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance. Tomography. 2016 Mar; 2(1):35-42. PMID: 27227168.
      View in: PubMed
    12. Zhao H, Yang L, Baddour J, Achreja A, Bernard V, Moss T, Marini JC, Tudawe T, Seviour EG, San Lucas FA, Alvarez H, Gupta S, Maiti SN, Cooper L, Peehl D, Ram PT, Maitra A, Nagrath D. Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism. Elife. 2016 Feb 27; 5:e10250. PMID: 26920219.
      View in: PubMed
    13. Valta MP, Zhao H, Saar M, Tuomela J, Nolley R, Linxweiler J, Sandholm J, Lehtimäki J, Härkönen P, Coleman I, Nelson PS, Corey E, Peehl DM. Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer. Clin Exp Metastasis. 2016 Apr; 33(4):325-37. PMID: 26873136.
      View in: PubMed
    14. Oronsky B, Scicinski J, Ning S, Peehl D, Oronsky A, Cabrales P, Bednarski M, Knox S. RRx-001, A novel dinitroazetidine radiosensitizer. Invest New Drugs. 2016 06; 34(3):371-7. PMID: 26841903; PMCID: PMC4859863.
    15. Zhao H, Leppert JT, Peehl DM. A Protective Role for Androgen Receptor in Clear Cell Renal Cell Carcinoma Based on Mining TCGA Data. PLoS One. 2016; 11(1):e0146505. PMID: 26814892.
      View in: PubMed
    16. Zhao H, Ning S, Scicinski J, Oronsky B, Knox SJ, Peehl DM. Epigenetic effects of RRx-001: a possible unifying mechanism of anticancer activity. Oncotarget. 2015 Dec 22; 6(41):43172-81. PMID: 26657731.
      View in: PubMed
    17. Ning S, Sekar TV, Scicinski J, Oronsky B, Peehl DM, Knox SJ, Paulmurugan R. Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001. Oncotarget. 2015 Aug 28; 6(25):21547-56. PMID: 26280276; PMCID: PMC4673285.
    18. Reid T, Oronsky B, Scicinski J, Scribner CL, Knox SJ, Ning S, Peehl DM, Korn R, Stirn M, Carter CA, Oronsky A, Taylor MJ, Fitch WL, Cabrales P, Kim MM, Burris HA, Lao CD, Abrouk NED, Fanger GR, Infante JR. Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study. Lancet Oncol. 2015 Sep; 16(9):1133-1142. PMID: 26296952.
      View in: PubMed
    19. Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O'Brien T, Sampath D, Carano RA, Kurhanewicz J. Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. Prostate. 2015 Oct; 75(14):1601-9. PMID: 26177608.
      View in: PubMed
    20. Scicinski J, Oronsky B, Ning S, Knox S, Peehl D, Kim MM, Langecker P, Fanger G. NO to cancer: The complex and multifaceted role of nitric oxide and the epigenetic nitric oxide donor, RRx-001. Redox Biol. 2015 Dec; 6:1-8. PMID: 26164533.
      View in: PubMed
    21. Mihelich BL, Maranville JC, Nolley R, Peehl DM, Nonn L. Elevated serum microRNA levels associate with absence of high-grade prostate cancer in a retrospective cohort. PLoS One. 2015; 10(4):e0124245. PMID: 25874774; PMCID: PMC4396984.
    22. Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV. Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res. 2015 Jun 01; 75(11):2254-63. PMID: 25858146; PMCID: PMC4454355.
    23. Rodrigues LU, Rider L, Nieto C, Romero L, Karimpour-Fard A, Loda M, Lucia MS, Wu M, Shi L, Cimic A, Sirintrapun SJ, Nolley R, Pac C, Chen H, Peehl DM, Xu J, Liu W, Costello JC, Cramer SD. Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer. Cancer Res. 2015 Mar 15; 75(6):1021-34. PMID: 25770290.
      View in: PubMed
    24. Cerchiari AE, Garbe JC, Jee NY, Todhunter ME, Broaders KE, Peehl DM, Desai TA, LaBarge MA, Thomson M, Gartner ZJ. A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2287-92. PMID: 25633040.
      View in: PubMed
    25. Wang Y, Roma A, Nolley R, Abdul-Karim F, Peehl DM, Eng C. Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma. Endocr Relat Cancer. 2014 Aug; 21(4):579-86. PMID: 24972837.
      View in: PubMed
    26. Saar M, Zhao H, Nolley R, Young SR, Coleman I, Nelson PS, Vessella RL, Peehl DM. Spheroid culture of LuCaP 147 as an authentic preclinical model of prostate cancer subtype with SPOP mutation and hypermutator phenotype. Cancer Lett. 2014 Sep 01; 351(2):272-80. PMID: 24998678.
      View in: PubMed
    27. Gao C, Liu Y, Zhang H, Zhang Y, Fukuda MN, Palma AS, Kozak RP, Childs RA, Nonaka M, Li Z, Siegel DL, Hanfland P, Peehl DM, Chai W, Greene MI, Feizi T. Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array. J Biol Chem. 2014 Jun 06; 289(23):16462-77. PMID: 24753245.
      View in: PubMed
    28. Nonaka M, Fukuda MN, Gao C, Li Z, Zhang H, Greene MI, Peehl DM, Feizi T, Fukuda M. Determination of carbohydrate structure recognized by prostate-specific F77 monoclonal antibody through expression analysis of glycosyltransferase genes. J Biol Chem. 2014 Jun 06; 289(23):16478-86. PMID: 24753248.
      View in: PubMed
    29. Valta MP, Zhao H, Ingels A, Thong AE, Nolley R, Saar M, Peehl DM. Development of a realistic in vivo bone metastasis model of human renal cell carcinoma. Clin Exp Metastasis. 2014 Jun; 31(5):573-84. PMID: 24715498; PMCID: PMC4351963.
    30. Pu K, Shuhendler AJ, Valta MP, Cui L, Saar M, Peehl DM, Rao J. Phosphorylcholine-coated semiconducting polymer nanoparticles as rapid and efficient labeling agents for in vivo cell tracking. Adv Healthc Mater. 2014 Aug; 3(8):1292-8. PMID: 24668903.
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    31. Maund SL, Nolley R, Peehl DM. Optimization and comprehensive characterization of a faithful tissue culture model of the benign and malignant human prostate. Lab Invest. 2014 Feb; 94(2):208-21. PMID: 24296879.
      View in: PubMed
    32. Belardi B, de la Zerda A, Spiciarich DR, Maund SL, Peehl DM, Bertozzi CR. Imaging the glycosylation state of cell surface glycoproteins by two-photon fluorescence lifetime imaging microscopy. Angew Chem Int Ed Engl. 2013 Dec 23; 52(52):14045-9. PMID: 24259491; PMCID: PMC3920747.
    33. Ingels A, Zhao H, Thong AE, Saar M, Valta MP, Nolley R, Santos J, Peehl DM. Preclinical trial of a new dual mTOR inhibitor, MLN0128, using renal cell carcinoma tumorgrafts. Int J Cancer. 2014 May 15; 134(10):2322-9. PMID: 24243565.
      View in: PubMed
    34. Tian J, Doi H, Saar M, Santos J, Li X, Peehl DM, Knox SJ. Radioprotection and cell cycle arrest of intestinal epithelial cells by darinaparsin, a tumor radiosensitizer. Int J Radiat Oncol Biol Phys. 2013 Dec 01; 87(5):1179-85. PMID: 24210080.
      View in: PubMed
    35. Af Hällström TM, Zhao H, Tian J, Rantanen V, Reese SW, Nolley R, Laiho M, Peehl DM. A tissue graft model of DNA damage response in the normal and malignant human prostate. J Urol. 2014 Mar; 191(3):842-9. PMID: 24035881.
      View in: PubMed
    36. Zhao H, Thong A, Nolley R, Reese SW, Santos J, Ingels A, Peehl DM. Patient-derived tissue slice grafts accurately depict response of high-risk primary prostate cancer to androgen deprivation therapy. J Transl Med. 2013 Aug 28; 11:199. PMID: 23985008.
      View in: PubMed
    37. Thong AE, Zhao H, Ingels A, Valta MP, Nolley R, Santos J, Young SR, Peehl DM. Tissue slice grafts of human renal cell carcinoma: an authentic preclinical model with high engraftment rate and metastatic potential. Urol Oncol. 2014 Jan; 32(1):43.e23-30. PMID: 23911681; PMCID: PMC4350678.
    38. Young SR, Saar M, Santos J, Nguyen HM, Vessella RL, Peehl DM. Establishment and serial passage of cell cultures derived from LuCaP xenografts. Prostate. 2013 Sep; 73(12):1251-62. PMID: 23740600; PMCID: PMC3720815.
    39. Zhao H, Sun N, Young SR, Nolley R, Santos J, Wu JC, Peehl DM. Induced pluripotency of human prostatic epithelial cells. PLoS One. 2013; 8(5):e64503. PMID: 23717621; PMCID: PMC3661502.
    40. Keshari KR, Sriram R, Van Criekinge M, Wilson DM, Wang ZJ, Vigneron DB, Peehl DM, Kurhanewicz J. Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. Prostate. 2013 Aug; 73(11):1171-81. PMID: 23532911; PMCID: PMC3976546.
    41. Wang D, Dafik L, Nolley R, Huang W, Wolfinger RD, Wang LX, Peehl DM. Anti-Oligomannose Antibodies as Potential Serum Biomarkers of Aggressive Prostate Cancer. Drug Dev Res. 2013 Mar; 74(2):65-80. PMID: 25152555.
      View in: PubMed
    42. Wang Y, Radhakrishnan D, He X, Peehl DM, Eng C. Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation. J Clin Endocrinol Metab. 2013 Mar; 98(3):E586-94. PMID: 23386643; PMCID: PMC3678149.
    43. Zhao H, Coram MA, Nolley R, Reese SW, Young SR, Peehl DM. Transcript levels of androgen receptor variant AR-V1 or AR-V7 do not predict recurrence in patients with prostate cancer at indeterminate risk for progression. J Urol. 2012 Dec; 188(6):2158-64. PMID: 23088973.
      View in: PubMed
    44. Tian J, Zhao H, Nolley R, Reese SW, Young SR, Li X, Peehl DM, Knox SJ. Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer. Clin Cancer Res. 2012 Jun 15; 18(12):3366-76. PMID: 22535156.
      View in: PubMed
    45. Hughes AJ, Lin RK, Peehl DM, Herr AE. Microfluidic integration for automated targeted proteomic assays. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):5972-7. PMID: 22474344; PMCID: PMC3341062.
    46. Wu M, Shi L, Cimic A, Romero L, Sui G, Lees CJ, Cline JM, Seals DF, Sirintrapun JS, McCoy TP, Liu W, Kim JW, Hawkins GA, Peehl DM, Xu J, Cramer SD. Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res. 2012 Jun 01; 72(11):2833-43. PMID: 22467172.
      View in: PubMed
    47. Ashida S, Orloff MS, Bebek G, Zhang L, Zheng P, Peehl DM, Eng C. Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes. Clin Cancer Res. 2012 Mar 15; 18(6):1578-87. PMID: 22275508.
      View in: PubMed
    48. Hubbard SC, Boyce M, McVaugh CT, Peehl DM, Bertozzi CR. Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):4945-50. PMID: 21798741; PMCID: PMC3341932.
    49. Kobayashi Y, Absher DM, Gulzar ZG, Young SR, McKenney JK, Peehl DM, Brooks JD, Myers RM, Sherlock G. DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer. Genome Res. 2011 Jul; 21(7):1017-27. PMID: 21521786; PMCID: PMC3129245.
    50. Brauer PM, Zheng Y, Evans MD, Dominguez-Brauer C, Peehl DM, Tyner AL. The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of ß-catenin. PLoS One. 2011 Mar 30; 6(3):e14789. PMID: 21479203; PMCID: PMC3068133.
    51. Peehl DM, Chen Z, Nolley R. Serum Mac-2BP does not distinguish men with high grade, large volume prostate cancer from men with benign prostatic hyperplasia. Prostate. 2011 Jan 01; 71(1):26-31. PMID: 20583127.
      View in: PubMed
    52. Peng Q, Omata S, Peehl DM, Constantinou CE. Stiffness mapping prostate biopsy samples using a tactile sensor. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:8515-8. PMID: 22256325.
      View in: PubMed
    53. Tian J, Peehl DM, Knox SJ. Metalloporphyrin synergizes with ascorbic acid to inhibit cancer cell growth through fenton chemistry. Cancer Biother Radiopharm. 2010 Aug; 25(4):439-48. PMID: 20735206.
      View in: PubMed
    54. Tian J, Peehl DM, Zheng W, Knox SJ. Anti-tumor and radiosensitization activities of the iron chelator HDp44mT are mediated by effects on intracellular redox status. Cancer Lett. 2010 Dec 08; 298(2):231-7. PMID: 20678860.
      View in: PubMed
    55. Zhao H, Nolley R, Chen Z, Peehl DM. Tissue slice grafts: an in vivo model of human prostate androgen signaling. Am J Pathol. 2010 Jul; 177(1):229-39. PMID: 20472887; PMCID: PMC2893666.
    56. Flamand V, Zhao H, Peehl DM. Targeting monoamine oxidase A in advanced prostate cancer. J Cancer Res Clin Oncol. 2010 Nov; 136(11):1761-71. PMID: 20204405.
      View in: PubMed
    57. Levin YS, Albers MJ, Butler TN, Spielman D, Peehl DM, Kurhanewicz J. Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrate. Magn Reson Med. 2009 Nov; 62(5):1091-8. PMID: 19780158.
      View in: PubMed
    58. Zhao H, Flamand V, Peehl DM. Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20; 2:55. PMID: 19691856; PMCID: PMC2736984.
    59. Zhao H, Peehl DM. Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts. Prostate. 2009 Jun 15; 69(9):991-1000. PMID: 19267366; PMCID: PMC2736596.
    60. Swami S, Krishnan AV, Moreno J, Bhattacharyya RS, Gardner C, Brooks JD, Peehl DM, Feldman D. Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients. Int J Cancer. 2009 May 01; 124(9):2050-9. PMID: 19127598.
      View in: PubMed
    61. Norris AM, Gentry M, Peehl DM, D'Agostino R, Scarpinato KD. The elevated expression of a mismatch repair protein is a predictor for biochemical recurrence after radical prostatectomy. Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18(1):57-64. PMID: 19124481.
      View in: PubMed
    62. Peehl DM, Coram M, Khine H, Reese S, Nolley R, Zhao H. The significance of monoamine oxidase-A expression in high grade prostate cancer. J Urol. 2008 Nov; 180(5):2206-11. PMID: 18804811.
      View in: PubMed
    63. Cramer SD, Sun J, Zheng SL, Xu J, Peehl DM. Association of prostate-specific antigen promoter genotype with clinical and histopathologic features of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2008 Sep; 17(9):2451-7. PMID: 18768516; PMCID: PMC4114034.
    64. Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D. Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. Cancer Res. 2008 Aug 15; 68(16):6831-9. PMID: 18701509; PMCID: PMC2597632.
    65. Das S, Hahn Y, Walker DA, Nagata S, Willingham MC, Peehl DM, Bera TK, Lee B, Pastan I. Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. Cancer Res. 2008 Aug 01; 68(15):6306-12. PMID: 18676855.
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    66. Pienta KJ, Abate-Shen C, Agus DB, Attar RM, Chung LW, Greenberg NM, Hahn WC, Isaacs JT, Navone NM, Peehl DM, Simons JW, Solit DB, Soule HR, VanDyke TA, Weber MJ, Wu L, Vessella RL. The current state of preclinical prostate cancer animal models. Prostate. 2008 May 01; 68(6):629-39. PMID: 18213636; PMCID: PMC3681409.
    67. Zhao H, Nolley R, Chen Z, Reese SW, Peehl DM. Inhibition of monoamine oxidase A promotes secretory differentiation in basal prostatic epithelial cells. Differentiation. 2008 Sep; 76(7):820-30. PMID: 18248494.
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    68. Krishnan AV, Moreno J, Nonn L, Swami S, Peehl DM, Feldman D. Calcitriol as a chemopreventive and therapeutic agent in prostate cancer: role of anti-inflammatory activity. J Bone Miner Res. 2007 Dec; 22 Suppl 2:V74-80. PMID: 18290727.
      View in: PubMed
    69. Krishnan AV, Swami S, Moreno J, Bhattacharyya RB, Peehl DM, Feldman D. Potentiation of the growth-inhibitory effects of vitamin D in prostate cancer by genistein. Nutr Rev. 2007 Aug; 65(8 Pt 2):S121-3. PMID: 17867387.
      View in: PubMed
    70. Feldman D, Krishnan A, Moreno J, Swami S, Peehl DM, Srinivas S. Vitamin D inhibition of the prostaglandin pathway as therapy for prostate cancer. Nutr Rev. 2007 Aug; 65(8 Pt 2):S113-5. PMID: 17867384.
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    71. Kiviharju-af Hällström TM, Jäämaa S, Mönkkönen M, Peltonen K, Andersson LC, Medema RH, Peehl DM, Laiho M. Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7211-6. PMID: 17431037.
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    72. Krishnan AV, Moreno J, Nonn L, Malloy P, Swami S, Peng L, Peehl DM, Feldman D. Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):694-702. PMID: 17229571.
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    73. Zhao H, Ramos CF, Brooks JD, Peehl DM. Distinctive gene expression of prostatic stromal cells cultured from diseased versus normal tissues. J Cell Physiol. 2007 Jan; 210(1):111-21. PMID: 17044071.
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    74. Murayama Y, Omata S, Yajima T, Peng Q, Shishido K, Peehl DM, Constantinou CE. High resolution regional elasticity mapping of the human prostate. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007:5803-6. PMID: 18003332.
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    75. Swami S, Krishnan AV, Moreno J, Bhattacharyya RB, Peehl DM, Feldman D. Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer. J Nutr. 2007 01; 137(1 Suppl):205S-210S. PMID: 17182827.
      View in: PubMed
    76. Nonn L, Duong D, Peehl DM. Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis. 2007 Jun; 28(6):1188-96. PMID: 17151092.
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    77. Bauman DR, Steckelbroeck S, Peehl DM, Penning TM. Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer. Endocrinology. 2006 Dec; 147(12):5806-16. PMID: 16959841.
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    78. Moreno J, Krishnan AV, Peehl DM, Feldman D. Mechanisms of vitamin D-mediated growth inhibition in prostate cancer cells: inhibition of the prostaglandin pathway. Anticancer Res. 2006 Jul-Aug; 26(4A):2525-30. PMID: 16886660.
      View in: PubMed
    79. Nonn L, Peng L, Feldman D, Peehl DM. Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D. Cancer Res. 2006 Apr 15; 66(8):4516-24. PMID: 16618780.
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    80. Vaday GG, Peehl DM, Kadam PA, Lawrence DM. Expression of CCL5 (RANTES) and CCR5 in prostate cancer. Prostate. 2006 Feb 01; 66(2):124-34. PMID: 16161154.
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    81. Husbeck B, Nonn L, Peehl DM, Knox SJ. Tumor-selective killing by selenite in patient-matched pairs of normal and malignant prostate cells. Prostate. 2006 Feb 01; 66(2):218-25. PMID: 16173037.
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    82. Chen N, Szentirmay MN, Pawar SA, Sirito M, Wang J, Wang Z, Zhai Q, Yang HX, Peehl DM, Ware JL, Sawadogo M. Tumor-suppression function of transcription factor USF2 in prostate carcinogenesis. Oncogene. 2006 Jan 26; 25(4):579-87. PMID: 16186802.
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    83. Penning TM, Steckelbroeck S, Bauman DR, Miller MW, Jin Y, Peehl DM, Fung KM, Lin HK. Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors. Mol Cell Endocrinol. 2006 Mar 27; 248(1-2):182-91. PMID: 16417966.
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    85. Swami S, Krishnan AV, Peehl DM, Feldman D. Genistein potentiates the growth inhibitory effects of 1,25-dihydroxyvitamin D3 in DU145 human prostate cancer cells: role of the direct inhibition of CYP24 enzyme activity. Mol Cell Endocrinol. 2005 Sep 28; 241(1-2):49-61. PMID: 15955619.
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    86. Bauman DR, Steckelbroeck S, Williams MV, Peehl DM, Penning TM. Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease. Mol Endocrinol. 2006 Feb; 20(2):444-58. PMID: 16179381.
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    88. Zhao H, Lai F, Nonn L, Brooks JD, Peehl DM. Molecular targets of doxazosin in human prostatic stromal cells. Prostate. 2005 Mar 01; 62(4):400-10. PMID: 15378519.
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    89. Peehl DM. Primary cell cultures as models of prostate cancer development. Endocr Relat Cancer. 2005 Mar; 12(1):19-47. PMID: 15788637.
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    90. Dallas SL, Zhao S, Cramer SD, Chen Z, Peehl DM, Bonewald LF. Preferential production of latent transforming growth factor beta-2 by primary prostatic epithelial cells and its activation by prostate-specific antigen. J Cell Physiol. 2005 Feb; 202(2):361-70. PMID: 15389580.
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    91. Husbeck B, Peehl DM, Knox SJ. Redox modulation of human prostate carcinoma cells by selenite increases radiation-induced cell killing. Free Radic Biol Med. 2005 Jan 01; 38(1):50-7. PMID: 15589371.
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    92. Peehl DM, Feldman D. Interaction of nuclear receptor ligands with the Vitamin D signaling pathway in prostate cancer. J Steroid Biochem Mol Biol. 2004 Nov; 92(4):307-15. PMID: 15663994.
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    93. San Francisco IF, DeWolf WC, Peehl DM, Olumi AF. Expression of transforming growth factor-beta 1 and growth in soft agar differentiate prostate carcinoma-associated fibroblasts from normal prostate fibroblasts. Int J Cancer. 2004 Nov 01; 112(2):213-8. PMID: 15352032.
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    94. Lee KL, Peehl DM. Molecular and cellular pathogenesis of benign prostatic hyperplasia. J Urol. 2004 Nov; 172(5 Pt 1):1784-91. PMID: 15540721.
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    95. Risbridger GP, Ball EM, Wang H, Mellor SL, Peehl DM. Re-evaluation of inhibin alpha subunit as a tumour suppressor in prostate cancer. Mol Cell Endocrinol. 2004 Oct 15; 225(1-2):73-6. PMID: 15451570.
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    97. Khanim FL, Gommersall LM, Wood VH, Smith KL, Montalvo L, O'Neill LP, Xu Y, Peehl DM, Stewart PM, Turner BM, Campbell MJ. Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells. Oncogene. 2004 Sep 02; 23(40):6712-25. PMID: 15300237.
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    98. Vaday GG, Hua SB, Peehl DM, Pauling MH, Lin YH, Zhu L, Lawrence DM, Foda HD, Zucker S. CXCR4 and CXCL12 (SDF-1) in prostate cancer: inhibitory effects of human single chain Fv antibodies. Clin Cancer Res. 2004 Aug 15; 10(16):5630-9. PMID: 15328206.
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    100. Krishnan AV, Shinghal R, Raghavachari N, Brooks JD, Peehl DM, Feldman D. Analysis of vitamin D-regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays. Prostate. 2004 May 15; 59(3):243-51. PMID: 15042599.
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    101. Gommersall LM, Khanim FL, Peehl DM, Doherty AH, Campbell MJ. Epigenetic repression of transcription by the Vitamin D3 receptor in prostate cancer cells. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):251-6. PMID: 15225780.
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    103. Risbridger GP, Shibata A, Ferguson KL, Stamey TA, McNeal JE, Peehl DM. Elevated expression of inhibin alpha in prostate cancer. J Urol. 2004 Jan; 171(1):192-6. PMID: 14665874.
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    104. He XY, Yang YZ, Peehl DM, Lauderdale A, Schulz H, Yang SY. Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol. 2003 Nov; 87(2-3):191-8. PMID: 14672739.
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    105. Krajewska M, Krajewski S, Banares S, Huang X, Turner B, Bubendorf L, Kallioniemi OP, Shabaik A, Vitiello A, Peehl D, Gao GJ, Reed JC. Elevated expression of inhibitor of apoptosis proteins in prostate cancer. Clin Cancer Res. 2003 Oct 15; 9(13):4914-25. PMID: 14581366.
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    106. Peehl DM, Krishnan AV, Feldman D. Pathways mediating the growth-inhibitory actions of vitamin D in prostate cancer. J Nutr. 2003 07; 133(7 Suppl):2461S-2469S. PMID: 12840225.
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    108. Xu Y, Iyengar S, Roberts RL, Shappell SB, Peehl DM. Primary culture model of peroxisome proliferator-activated receptor gamma activity in prostate cancer cells. J Cell Physiol. 2003 Jul; 196(1):131-43. PMID: 12767049.
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    110. Moore MG, Wetterau LA, Francis MJ, Peehl DM, Cohen P. Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells. Int J Cancer. 2003 May 20; 105(1):14-9. PMID: 12672024.
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    111. Lecane PS, Kiviharju TM, Sellers RG, Peehl DM. Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line. Prostate. 2003 Mar 01; 54(4):258-67. PMID: 12539224.
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    116. Peehl DM, Seto E, Hsu JY, Feldman D. Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells. J Urol. 2002 Oct; 168(4 Pt 1):1583-8. PMID: 12352462.
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    117. Shibata A, Garcia MI, Cheng I, Stamey TA, McNeal JE, Brooks JD, Henderson S, Yemoto CE, Peehl DM. Polymorphisms in the androgen receptor and type II 5 alpha-reductase genes and prostate cancer prognosis. Prostate. 2002 Sep 01; 52(4):269-78. PMID: 12210487.
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    118. Kiviharju TM, Lecane PS, Sellers RG, Peehl DM. Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin Cancer Res. 2002 Aug; 8(8):2666-74. PMID: 12171899.
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    119. Vidanes GM, Paton V, Wallen E, Peehl DM, Navone N, Brooks JD. Silencing of pi-class glutathione S-transferase in MDA PCa 2a and MDA PCa 2b cells. Prostate. 2002 Jun 01; 51(4):225-30. PMID: 11987150.
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    120. Krishnan AV, Zhao XY, Swami S, Brive L, Peehl DM, Ely KR, Feldman D. A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer. Endocrinology. 2002 May; 143(5):1889-900. PMID: 11956172.
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    121. Wilson MJ, Sellers RG, Wiehr C, Melamud O, Pei D, Peehl DM. Expression of matrix metalloproteinase-2 and -9 and their inhibitors, tissue inhibitor of metalloproteinase-1 and -2, in primary cultures of human prostatic stromal and epithelial cells. J Cell Physiol. 2002 May; 191(2):208-16. PMID: 12064464.
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    122. Guo X, Knudsen BS, Peehl DM, Ruiz A, Bok D, Rando RR, Rhim JS, Nanus DM, Gudas LJ. Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens. Cancer Res. 2002 Mar 15; 62(6):1654-61. PMID: 11912136.
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    123. Nakamura K, Yasunaga Y, Ko D, Xu LL, Moul JW, Peehl DM, Srivastava S, Rhim JS. Cadmium-induced neoplastic transformation of human prostate epithelial cells. Int J Oncol. 2002 Mar; 20(3):543-7. PMID: 11836566.
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    124. Armstrong JS, Steinauer KK, Hornung B, Irish JM, Lecane P, Birrell GW, Peehl DM, Knox SJ. Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line. Cell Death Differ. 2002 Mar; 9(3):252-63. PMID: 11859408.
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    125. Shibata A, Stamey TA, McNeal JE, Cheng I, Peehl DM. Genetic polymorphisms in the androgen receptor and type II 5 alpha-reductase genes in prostate enlargement. J Urol. 2001 Oct; 166(4):1560-4. PMID: 11547131.
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    126. Ma JF, Takito J, Vijayakumar S, Peehl DM, Olsson CA, Al-Awqati Q. Prostatic expression of hensin, a protein implicated in epithelial terminal differentiation. Prostate. 2001 Sep 15; 49(1):9-18. PMID: 11550206.
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    127. Liu AY, Peehl DM. Characterization of cultured human prostatic epithelial cells by cluster designation antigen expression. Cell Tissue Res. 2001 Sep; 305(3):389-97. PMID: 11572092.
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    128. Carroll PR, Fair WR, Grossfeld GD, Heston WD, Lieberman R, Malkowicz SB, Stricker HJ, Sylvester J, Peehl DM, Meyer F, Hart C. Overview consensus statement. Urology. 2001 Aug; 58(2 Suppl 1):1-4. PMID: 11502434.
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    129. Peehl DM, Seto E, Feldman D. Rationale for combination ketoconazole/ vitamin D treatment of prostate cancer. Urology. 2001 Aug; 58(2 Suppl 1):123-6. PMID: 11502466.
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    130. Miao H, Wei BR, Peehl DM, Li Q, Alexandrou T, Schelling JR, Rhim JS, Sedor JR, Burnett E, Wang B. Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway. Nat Cell Biol. 2001 May; 3(5):527-30. PMID: 11331884.
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    131. Hsu JY, Feldman D, McNeal JE, Peehl DM. Reduced 1alpha-hydroxylase activity in human prostate cancer cells correlates with decreased susceptibility to 25-hydroxyvitamin D3-induced growth inhibition. Cancer Res. 2001 Apr 01; 61(7):2852-6. PMID: 11306457.
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    132. Hayes SA, Zarnegar M, Sharma M, Yang F, Peehl DM, ten Dijke P, Sun Z. SMAD3 represses androgen receptor-mediated transcription. Cancer Res. 2001 Mar 01; 61(5):2112-8. PMID: 11280774.
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    133. Peehl DM, Sellers RG. Cultured stromal cells: an in vitro model of prostatic mesenchymal biology. Prostate. 2000 Oct 01; 45(2):115-23. PMID: 11027410.
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    134. Wallen E, Sellers RG, Peehl DM. Brefeldin A induces p53-independent apoptosis in primary cultures of human prostatic cancer cells. J Urol. 2000 Sep; 164(3 Pt 1):836-41. PMID: 10953164.
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    135. Hukku B, Mally M, Cher ML, Peehl DM, Kung H, Rhim JS. Stepwise genetic changes associated with progression of nontumorigenic HPV-18 immortalized human prostate cancer-derived cell line to a malignant phenotype. Cancer Genet Cytogenet. 2000 Jul 15; 120(2):117-26. PMID: 10942801.
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    136. Choi J, Shendrik I, Peacocke M, Peehl D, Buttyan R, Ikeguchi EF, Katz AE, Benson MC. Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia. Urology. 2000 Jul; 56(1):160-6. PMID: 10869659.
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    137. Zhao XY, Peehl DM, Navone NM, Feldman D. 1alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell growth by androgen-dependent and androgen-independent mechanisms. Endocrinology. 2000 Jul; 141(7):2548-56. PMID: 10875257.
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    138. Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, Peehl DM, Feldman D. Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med. 2000 Jun; 6(6):703-6. PMID: 10835690.
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    139. Sandhu C, Peehl DM, Slingerland J. p16INK4A mediates cyclin dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells. Cancer Res. 2000 May 15; 60(10):2616-22. PMID: 10825132.
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    140. Cohen P, Nunn SE, Peehl DM. Transforming growth factor-beta induces growth inhibition and IGF-binding protein-3 production in prostatic stromal cells: abnormalities in cells cultured from benign prostatic hyperplasia tissues. J Endocrinol. 2000 Feb; 164(2):215-23. PMID: 10657857.
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    142. Peehl DM, Sellers RG, Arnstein P, Kung HF, Rhim JS. Altered growth regulation and loss of response to retinoic acid accompany tumorigenic transformation of prostatic cells. Anticancer Res. 1999 Sep-Oct; 19(5B):3857-64. PMID: 10628324.
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    144. Peehl DM. Vitamin D and prostate cancer risk. Eur Urol. 1999; 35(5-6):392-4. PMID: 10325494.
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    145. Cohen P, Peehl DM, Rosenfeld R. Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia. Br J Cancer. 1998 Aug; 78(4):554-6. PMID: 9716045.
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    151. Kim CY, Tsai MH, Osmanian C, Graeber TG, Lee JE, Giffard RG, DiPaolo JA, Peehl DM, Giaccia AJ. Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Cancer Res. 1997 Oct 01; 57(19):4200-4. PMID: 9331075.
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    155. Terris MK, Peehl DM. Human papillomavirus detection by polymerase chain reaction in benign and malignant prostate tissue is dependent on the primer set utilized. Urology. 1997 Jul; 50(1):150-6. PMID: 9218040.
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    156. Peehl DM, Sellers RG. Induction of smooth muscle cell phenotype in cultured human prostatic stromal cells. Exp Cell Res. 1997 May 01; 232(2):208-15. PMID: 9168795.
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    157. Nunn SE, Peehl DM, Cohen P. Acid-activated insulin-like growth factor binding protein protease activity of cathepsin D in normal and malignant prostatic epithelial cells and seminal plasma. J Cell Physiol. 1997 May; 171(2):196-204. PMID: 9130467.
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    158. Peehl DM, Edgar MG, Cramer SD, Deftos LJ. Parathyroid hormone-related protein is not an autocrine growth factor for normal prostatic epithelial cells. Prostate. 1997 Apr 01; 31(1):47-52. PMID: 9108886.
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    160. Miniati DN, Chang Y, Shu WP, Peehl DM, Liu BC. Role of prostatic basal cells in the regulation and suppression of human prostate cancer cells. Cancer Lett. 1996 Jul 12; 104(2):137-44. PMID: 8665481.
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    161. Cramer SD, Peehl DM, Edgar MG, Wong ST, Deftos LJ, Feldman D. Parathyroid hormone--related protein (PTHrP) is an epidermal growth factor-regulated secretory product of human prostatic epithelial cells. Prostate. 1996 Jul; 29(1):20-9. PMID: 8685051.
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    162. Rajah R, Bhala A, Nunn SE, Peehl DM, Cohen P. 7S nerve growth factor is an insulin-like growth factor-binding protein protease. Endocrinology. 1996 Jul; 137(7):2676-82. PMID: 8770886.
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    167. Peehl DM, Wong ST, Rubin JS. KGF and EGF differentially regulate the phenotype of prostatic epithelial cells. Growth Regul. 1996 Mar; 6(1):22-31. PMID: 8717447.
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    175. Feldman D, Skowronski RJ, Peehl DM. Vitamin D and prostate cancer. Adv Exp Med Biol. 1995; 375:53-63. PMID: 7645428.
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    178. Weijerman PC, König JJ, Wong ST, Niesters HG, Peehl DM. Lipofection-mediated immortalization of human prostatic epithelial cells of normal and malignant origin using human papillomavirus type 18 DNA. Cancer Res. 1994 Nov 01; 54(21):5579-83. PMID: 7923200.
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    180. Lee KO, Oh Y, Giudice LC, Cohen P, Peehl DM, Rosenfeld RG. Identification of insulin-like growth factor-binding protein-3 (IGFBP-3) fragments and IGFBP-5 proteolytic activity in human seminal plasma: a comparison of normal and vasectomized patients. J Clin Endocrinol Metab. 1994 Nov; 79(5):1367-72. PMID: 7525634.
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    182. Peehl DM, Leung GK, Wong ST. Keratin expression: a measure of phenotypic modulation of human prostatic epithelial cells by growth inhibitory factors. Cell Tissue Res. 1994 Jul; 277(1):11-8. PMID: 7519968.
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    183. Lee M, Garkovenko E, Yun J, Weijerman P, Peehl D, Chen L, Rhim J. Characterization of adult human prostatic epithelial-cells immortalized by polybrene-induced DNA transfection with a plasmid containing an origin-defective sv40-genome. Int J Oncol. 1994 Apr; 4(4):821-30. PMID: 21566988.
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    184. Peehl DM, Skowronski RJ, Leung GK, Wong ST, Stamey TA, Feldman D. Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells. Cancer Res. 1994 Feb 01; 54(3):805-10. PMID: 7508338.
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    185. Cohen P, Peehl DM, Rosenfeld RG. The IGF axis in the prostate. Horm Metab Res. 1994 Feb; 26(2):81-4. PMID: 8200618.
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    186. Weijerman PC, Romijn HC, Peehl DM. Human papilloma virus type 18 DNA immortalized cell lines from the human prostate epithelium. Prog Clin Biol Res. 1994; 386:67-9. PMID: 7800701.
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    187. Pastan I, Lovelace E, Rutherford AV, Kunwar S, Willingham MC, Peehl DM. PR1--a monoclonal antibody that reacts with an antigen on the surface of normal and malignant prostate cells. J Natl Cancer Inst. 1993 Jul 21; 85(14):1149-54. PMID: 7686582.
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    188. Skowronski RJ, Peehl DM, Feldman D. Vitamin D and prostate cancer: 1,25 dihydroxyvitamin D3 receptors and actions in human prostate cancer cell lines. Endocrinology. 1993 May; 132(5):1952-60. PMID: 7682937.
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    189. Cohen P, Peehl DM, Stamey TA, Wilson KF, Clemmons DR, Rosenfeld RG. Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients. J Clin Endocrinol Metab. 1993 Apr; 76(4):1031-5. PMID: 7682560.
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    190. Peehl DM. Oncogenes in prostate cancer. An update. Cancer. 1993 Feb 01; 71(3 Suppl):1159-64. PMID: 8428339.
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    191. Peehl DM, Wong ST, Stamey TA. Vitamin A regulates proliferation and differentiation of human prostatic epithelial cells. Prostate. 1993; 23(1):69-78. PMID: 7687781.
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    192. Cohen P, Graves HC, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG. Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab. 1992 Oct; 75(4):1046-53. PMID: 1383255.
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    193. Brothman AR, Patel AM, Peehl DM, Schellhammer PF. Analysis of prostatic tumor cultures using fluorescence in-situ hybridization (FISH). Cancer Genet Cytogenet. 1992 Sep; 62(2):180-5. PMID: 1394106.
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    194. Brothman AR, Peehl DM, Patel AM, MacDonald GR, McNeal JE, Ladaga LE, Schellhammer PF. Cytogenetic evaluation of 20 cultured primary prostatic tumors. Cancer Genet Cytogenet. 1991 Aug; 55(1):79-84. PMID: 1913611.
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    195. Cohen P, Peehl DM, Lamson G, Rosenfeld RG. Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial cells. J Clin Endocrinol Metab. 1991 Aug; 73(2):401-7. PMID: 1713219.
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    196. Yacoe ME, Sommer G, Peehl D. In vitro proton spectroscopy of normal and abnormal prostate. Magn Reson Med. 1991 Jun; 19(2):429-38. PMID: 1715505.
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    197. Peehl DM, Wong ST, Stamey TA. Cytostatic effects of suramin on prostate cancer cells cultured from primary tumors. J Urol. 1991 Mar; 145(3):624-30. PMID: 1705296.
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    198. Peehl DM. Searching for suppressor genes in prostate cancer. Cancer Surv. 1991; 11:25-34. PMID: 1668728.
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    199. Peehl DM, Wong ST, Terris MK, Stamey TA. Culture of prostatic epithelial cells from ultrasound-guided needle biopsies. Prostate. 1991; 19(2):141-7. PMID: 1717964.
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    200. Yaswen P, Smoll A, Peehl DM, Trask DK, Sager R, Stampfer MR. Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7360-4. PMID: 2217169.
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    201. Brothman AR, Peehl DM, Patel AM, McNeal JE. Frequency and pattern of karyotypic abnormalities in human prostate cancer. Cancer Res. 1990 Jun 15; 50(12):3795-803. PMID: 2340524.
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    202. Peehl DM, Wong ST, McNeal JE, Stamey TA. Analysis of somatic cell hybrids derived from normal human prostatic epithelial cells fused with HeLa cells. Prostate. 1990; 17(2):123-36. PMID: 1697966.
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    203. Kaighn ME, Reddel RR, Lechner JF, Peehl DM, Camalier RF, Brash DE, Saffiotti U, Harris CC. Transformation of human neonatal prostate epithelial cells by strontium phosphate transfection with a plasmid containing SV40 early region genes. Cancer Res. 1989 Jun 01; 49(11):3050-6. PMID: 2541897.
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    204. Peehl DM, Wong ST, Bazinet M, Stamey TA. In vitro studies of human prostatic epithelial cells: attempts to identify distinguishing features of malignant cells. Growth Factors. 1989; 1(3):237-50. PMID: 2698220.
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    205. Kabalin JN, Peehl DM, Stamey TA. Clonal growth of human prostatic epithelial cells is stimulated by fibroblasts. Prostate. 1989; 14(3):251-63. PMID: 2499876.
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    206. Peehl DM, Wong ST, Stamey TA. Clonal growth characteristics of adult human prostatic epithelial cells. In Vitro Cell Dev Biol. 1988 Jun; 24(6):530-6. PMID: 3391931.
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    207. Peehl DM, Wehner N, Stamey TA. Activated Ki-ras oncogene in human prostatic adenocarcinoma. Prostate. 1987; 10(4):281-9. PMID: 3601807.
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    208. Peehl DM. Oncogene expression. Prog Clin Biol Res. 1987; 239:77-90. PMID: 3309967.
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    209. Peehl DM, Stamey TA. Oncogenes: a review with relevance to cancers of the urogenital tract. J Urol. 1986 May; 135(5):897-904. PMID: 3007783.
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    210. Peehl DM, Stamey TA. Serum-free growth of adult human prostatic epithelial cells. In Vitro Cell Dev Biol. 1986 Feb; 22(2):82-90. PMID: 2419302.
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    211. Peehl DM, Stamey TA. Growth responses of normal, benign hyperplastic, and malignant human prostatic epithelial cells in vitro to cholera toxin, pituitary extract, and hydrocortisone. Prostate. 1986; 8(1):51-61. PMID: 2418431.
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    212. Brawer MK, Peehl DM, Stamey TA, Bostwick DG. Keratin immunoreactivity in the benign and neoplastic human prostate. Cancer Res. 1985 Aug; 45(8):3663-7. PMID: 2410099.
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    213. Peehl DM, Stamey TA. Serial propagation of adult human prostatic epithelial cells with cholera toxin. In Vitro. 1984 Dec; 20(12):981-6. PMID: 6085065.
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    214. Peehl DM, Stanbridge EJ. The role of differentiation in the suppression of tumorigenicity in human cell hybrids. Int J Cancer. 1982 Jul 15; 30(1):113-20. PMID: 7118295.
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    215. Stanbridge EJ, Der CJ, Doersen CJ, Nishimi RY, Peehl DM, Weissman BE, Wilkinson JE. Human cell hybrids: analysis of transformation and tumorigenicity. Science. 1982 Jan 15; 215(4530):252-9. PMID: 7053574.
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    216. Peehl DM, Stanbridge EJ. Characterization of human keratinocyte X HeLa somatic cell hybrids. Int J Cancer. 1981 May 15; 27(5):625-35. PMID: 6169665.
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    217. Peehl DM, Ham RG. Clonal growth of human keratinocytes with small amounts of dialyzed serum. In Vitro. 1980 Jun; 16(6):526-40. PMID: 6156122.
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    218. Peehl DM, Ham RG. Growth and differentiation of human keratinocytes without a feeder layer or conditioned medium. In Vitro. 1980 Jun; 16(6):516-25. PMID: 6156121.
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