Donna Peehl, PhD

Title(s)Professor, Radiology
SchoolSchool of Medicine
Address1700 4th St
San Francisco CA 94158
Phone650-725-5531
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Postdoctoral FellowOncogenes
    University of California, Irvine Postdoctoral FellowTumor Suppressors
    University of Colorado, Boulder Doctor of PhilosophyMolecular, Cellular and Developmental Biology
    Stanford University, California UndergraduateBiology
    Collapse Awards and Honors
    SWIU/SBUR 2016Award for Excellence in Urologic Research

    Collapse Overview 
    Collapse Overview
    Donna Peehl, PhD, is an adjunct Professor in the Body Research Interest Group in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. She received her undergraduate degree in biology at Stanford University in California and completed her PhD in Molecular, Cellular and Developmental Biology at the University of Colorado in Boulder. During postdoctoral fellowship research at the University of California in Irvine and San Francisco, she investigated tumor suppressor genes and oncogenes in cancer. Prior to joining UCSF, Dr. Peehl became Professor Emerita at Stanford University, California, after 35 years as a basic scientist in the Department of Urology. She is widely recognized for her work in developing realistic and representative preclinical cell and tissue models of prostate and kidney cancer.

    Dr. Peehl’s current studies focus on developing novel therapeutics for prostate and kidney cancer. In collaboration with investigators at UCSF and Stanford, she is testing novel inhibitors of the tyrosine kinase AXL and of the scaffold protein, IQGAP, for their anti-cancer activity in her patient-derived models of kidney cancer. Another project uses tissue slice cultures to investigate cancer-associated glycosylation as a novel immunotherapy target. Under the auspices of a new NIH U01 grant, Dr. Peehl is collaborating with Dr. John Kurhanewicz and others at UCSF to compare metabolism of four types of kidney cancer preclinical models by hyperpolarized molecular imaging.

    Dr. Peehl has been the recipient of numerous grants from the NIH and Department of Defense (DoD) Prostate Cancer Research Program, and has received awards from the Prostate Cancer Foundation (formerly CaP CURE) to support her research. She has served as chair or scientist reviewer for many NIH and grant review panels and has reviewed or served on the editorial board for a large number of scientific journals. Her peer-reviews include over 200 articles and publications.

    Expertise:
    Urology

    Specialty:
    Prostate cancer, kidney cancer, molecular and cellular biology

    Professional Interests:
    Patient-derived xenografts, tissue slice cultures, primary cultures, spheroid cultures, preclinical drug testing, biomarkers, metabolism, cancer biology, translational science

    Collapse Research 
    Collapse Research Activities and Funding
    Co-Clinical Quantitative Imaging of Small Cell Neuroendocrine Prostate Cancer Using Hyperpolarized 13C MRI
    NIH U24CA253377Sep 7, 2020 - Aug 31, 2025
    Role: Co-Principal Investigator
    Metabolic imaging comparisons of patient-derived models of renal cell carcinoma
    NIH U01CA217456Sep 1, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    A Serum Marker for Aggressive Prostate Cancer
    NIH R01CA121460Aug 28, 2006 - Jul 31, 2013
    Role: Principal Investigator
    GROWTH FACTORS IN THE PROSTATE: AN IN VITRO MODEL
    NIH R01DK047551Sep 30, 1993 - Aug 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. MAP3K7 Loss Drives Enhanced Androgen Signaling and Independently Confers Risk of Recurrence in Prostate Cancer with Joint Loss of CHD1. Mol Cancer Res. 2021 Apr 12. Jillson LK, Rider LC, Rodrigues LU, Romero L, Karimpour-Fard A, Nieto C, Gillette C, Torkko K, Danis E, Smith EE, Nolley R, Peehl DM, Lucia MS, Costello JC, Cramer SD. PMID: 33846123.
      View in: PubMed   Mentions: 1     Fields:    
    2. Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models. Metabolites. 2021 Feb 26; 11(3). Sun J, Bok RA, DeLos Santos J, Upadhyay D, DeLos Santos R, Agarwal S, Van Criekinge M, Vigneron DB, Aggarwal R, Peehl DM, Kurhanewicz J, Sriram R. PMID: 33652703.
      View in: PubMed   Mentions:
    3. Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures. Cancers (Basel). 2020 Feb 26; 12(3). Sriram R, Van Criekinge M, DeLos Santos J, Ahamed F, Qin H, Nolley R, Santos RD, Tabatabai ZL, Bok RA, Keshari KR, Vigneron DB, Peehl DM, Kurhanewicz J. PMID: 32110965.
      View in: PubMed   Mentions:
    4. Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2032-2042. Hsu EC, Rice MA, Bermudez A, Marques FJG, Aslan M, Liu S, Ghoochani A, Zhang CA, Chen YS, Zlitni A, Kumar S, Nolley R, Habte F, Shen M, Koul K, Peehl DM, Zoubeidi A, Gambhir SS, Kunder CA, Pitteri SJ, Brooks JD, Stoyanova T. PMID: 31932422.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    5. S100A10 Is a Critical Mediator of GAS6/AXL-Induced Angiogenesis in Renal Cell Carcinoma. Cancer Res. 2019 11 15; 79(22):5758-5768. Xiao Y, Zhao H, Tian L, Nolley R, Diep AN, Ernst A, Fuh KC, Miao YR, von Eyben R, Leppert JT, Brooks JD, Peehl DM, Giaccia AJ, Rankin EB. PMID: 31585940.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    6. miR-22 Regulates Invasion, Gene Expression and Predicts Overall Survival in Patients with Clear Cell Renal Cell Carcinoma. Kidney Cancer. 2019 Aug 07; 3(2):119-132. Gong X, Zhao H, Saar M, Peehl DM, Brooks JD. PMID: 31763513.
      View in: PubMed   Mentions:
    7. NMR quantification of lactate production and efflux and glutamate fractional enrichment in living human prostate biopsies cultured with [1,6-13 C2 ]glucose. Magn Reson Med. 2019 08; 82(2):566-576. Bancroft Brown J, Sriram R, VanCriekinge M, Delos Santos R, Sun J, Delos Santos J, Tabatabai ZL, Shinohara K, Nguyen H, Peehl DM, Kurhanewicz J. PMID: 30924180.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. A note on improved statistical approaches to account for pseudoprogression. Cancer Chemother Pharmacol. 2018 03; 81(3):621-626. Abrouk N, Oronsky B, Caroen S, Ning S, Knox S, Peehl D. PMID: 29404682.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics. Angew Chem Int Ed Engl. 2017 07 24; 56(31):8992-8997. Spiciarich DR, Nolley R, Maund SL, Purcell SC, Herschel J, Iavarone AT, Peehl DM, Bertozzi CR. PMID: 28649697.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    10. The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry. Clin Epigenetics. 2017; 9:4. Zhao H, Ning S, Nolley R, Scicinski J, Oronsky B, Knox SJ, Peehl DM. PMID: 28149332.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    11. RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials. Expert Opin Investig Drugs. 2017 01; 26(1):109-119. Oronsky B, Paulmurugan R, Foygel K, Scicinski J, Knox SJ, Peehl D, Zhao H, Ning S, Cabrales P, Summers TA, Reid TR, Fitch WL, Kim MM, Trepel JB, Lee MJ, Kesari S, Abrouk ND, Day RM, Oronsky A, Ray CM, Carter CA. PMID: 27935336.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    12. Cabozantinib inhibits tumor growth and metastasis of a patient-derived xenograft model of papillary renal cell carcinoma with MET mutation. . 2017 Nov 02; 18(11):863-871. Zhao H, Nolley R, Chan AMW, Rankin EB, Peehl DM. PMID: 27715452.
      View in: PubMed   Mentions:
    13. Endoscopic detection of cancer with lensless radioluminescence imaging and machine vision. Sci Rep. 2016 08 01; 6:30737. Türkcan S, Naczynski DJ, Nolley R, Sasportas LS, Peehl DM, Pratx G. PMID: 27477912.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    14. Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance. Tomography. 2016 Mar; 2(1):35-42. Sriram R, Van Criekinge M, DeLos Santos J, Keshari KR, Wilson DM, Peehl D, Kurhanewicz J, Wang ZJ. PMID: 27227168.
      View in: PubMed   Mentions: 12     Fields:    
    15. Rockets, radiosensitizers, and RRx-001: an origin story part I. Discov Med. 2016 03; 21(115):173-80. Oronsky B, Scicinski J, Ning S, Peehl D, Oronsky A, Cabrales P, Bednarski M, Knox S. PMID: 27115167.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    16. Spheroid culture of LuCaP 136 patient-derived xenograft enables versatile preclinical models of prostate cancer. Clin Exp Metastasis. 2016 Apr; 33(4):325-37. Valta MP, Zhao H, Saar M, Tuomela J, Nolley R, Linxweiler J, Sandholm J, Lehtimäki J, Härkönen P, Coleman I, Nelson PS, Corey E, Peehl DM. PMID: 26873136.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. RRx-001, A novel dinitroazetidine radiosensitizer. Invest New Drugs. 2016 06; 34(3):371-7. Oronsky B, Scicinski J, Ning S, Peehl D, Oronsky A, Cabrales P, Bednarski M, Knox S. PMID: 26841903.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    18. A Protective Role for Androgen Receptor in Clear Cell Renal Cell Carcinoma Based on Mining TCGA Data. PLoS One. 2016; 11(1):e0146505. Zhao H, Leppert JT, Peehl DM. PMID: 26814892.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    19. Epigenetic effects of RRx-001: a possible unifying mechanism of anticancer activity. Oncotarget. 2015 Dec 22; 6(41):43172-81. Zhao H, Ning S, Scicinski J, Oronsky B, Knox SJ, Peehl DM. PMID: 26657731.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    20. Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001. Oncotarget. 2015 Aug 28; 6(25):21547-56. Ning S, Sekar TV, Scicinski J, Oronsky B, Peehl DM, Knox SJ, Paulmurugan R. PMID: 26280276.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    21. Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study. Lancet Oncol. 2015 Sep; 16(9):1133-1142. Reid T, Oronsky B, Scicinski J, Scribner CL, Knox SJ, Ning S, Peehl DM, Korn R, Stirn M, Carter CA, Oronsky A, Taylor MJ, Fitch WL, Cabrales P, Kim MM, Burris HA, Lao CD, Abrouk NED, Fanger GR, Infante JR. PMID: 26296952.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCTClinical Trials
    22. Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. Prostate. 2015 Oct; 75(14):1601-9. Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O'Brien T, Sampath D, Carano RA, Kurhanewicz J. PMID: 26177608.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    23. NO to cancer: The complex and multifaceted role of nitric oxide and the epigenetic nitric oxide donor, RRx-001. Redox Biol. 2015 Dec; 6:1-8. Scicinski J, Oronsky B, Ning S, Knox S, Peehl D, Kim MM, Langecker P, Fanger G. PMID: 26164533.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    24. Elevated serum microRNA levels associate with absence of high-grade prostate cancer in a retrospective cohort. PLoS One. 2015; 10(4):e0124245. Mihelich BL, Maranville JC, Nolley R, Peehl DM, Nonn L. PMID: 25874774.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    25. Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res. 2015 Jun 01; 75(11):2254-63. Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV. PMID: 25858146.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    26. Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer. Cancer Res. 2015 Mar 15; 75(6):1021-34. Rodrigues LU, Rider L, Nieto C, Romero L, Karimpour-Fard A, Loda M, Lucia MS, Wu M, Shi L, Cimic A, Sirintrapun SJ, Nolley R, Pac C, Chen H, Peehl DM, Xu J, Liu W, Costello JC, Cramer SD. PMID: 25770290.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    27. A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2287-92. Cerchiari AE, Garbe JC, Jee NY, Todhunter ME, Broaders KE, Peehl DM, Desai TA, LaBarge MA, Thomson M, Gartner ZJ. PMID: 25633040.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    28. Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma. Endocr Relat Cancer. 2014 Aug; 21(4):579-86. Wang Y, Roma A, Nolley R, Abdul-Karim F, Peehl DM, Eng C. PMID: 24972837.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    29. Spheroid culture of LuCaP 147 as an authentic preclinical model of prostate cancer subtype with SPOP mutation and hypermutator phenotype. Cancer Lett. 2014 Sep 01; 351(2):272-80. Saar M, Zhao H, Nolley R, Young SR, Coleman I, Nelson PS, Vessella RL, Peehl DM. PMID: 24998678.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    30. Determination of carbohydrate structure recognized by prostate-specific F77 monoclonal antibody through expression analysis of glycosyltransferase genes. J Biol Chem. 2014 Jun 06; 289(23):16478-86. Nonaka M, Fukuda MN, Gao C, Li Z, Zhang H, Greene MI, Peehl DM, Feizi T, Fukuda M. PMID: 24753248.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    31. Development of a realistic in vivo bone metastasis model of human renal cell carcinoma. Clin Exp Metastasis. 2014 Jun; 31(5):573-84. Valta MP, Zhao H, Ingels A, Thong AE, Nolley R, Saar M, Peehl DM. PMID: 24715498.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    32. Phosphorylcholine-coated semiconducting polymer nanoparticles as rapid and efficient labeling agents for in vivo cell tracking. Adv Healthc Mater. 2014 Aug; 3(8):1292-8. Pu K, Shuhendler AJ, Valta MP, Cui L, Saar M, Peehl DM, Rao J. PMID: 24668903.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    33. Optimization and comprehensive characterization of a faithful tissue culture model of the benign and malignant human prostate. Lab Invest. 2014 Feb; 94(2):208-21. Maund SL, Nolley R, Peehl DM. PMID: 24296879.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    34. Imaging the glycosylation state of cell surface glycoproteins by two-photon fluorescence lifetime imaging microscopy. Angew Chem Int Ed Engl. 2013 Dec 23; 52(52):14045-9. Belardi B, de la Zerda A, Spiciarich DR, Maund SL, Peehl DM, Bertozzi CR. PMID: 24259491.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    35. Preclinical trial of a new dual mTOR inhibitor, MLN0128, using renal cell carcinoma tumorgrafts. Int J Cancer. 2014 May 15; 134(10):2322-9. Ingels A, Zhao H, Thong AE, Saar M, Valta MP, Nolley R, Santos J, Peehl DM. PMID: 24243565.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    36. Radioprotection and cell cycle arrest of intestinal epithelial cells by darinaparsin, a tumor radiosensitizer. Int J Radiat Oncol Biol Phys. 2013 Dec 01; 87(5):1179-85. Tian J, Doi H, Saar M, Santos J, Li X, Peehl DM, Knox SJ. PMID: 24210080.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    37. A tissue graft model of DNA damage response in the normal and malignant human prostate. J Urol. 2014 Mar; 191(3):842-9. Af Hällström TM, Zhao H, Tian J, Rantanen V, Reese SW, Nolley R, Laiho M, Peehl DM. PMID: 24035881.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    38. Patient-derived tissue slice grafts accurately depict response of high-risk primary prostate cancer to androgen deprivation therapy. J Transl Med. 2013 Aug 28; 11:199. Zhao H, Thong A, Nolley R, Reese SW, Santos J, Ingels A, Peehl DM. PMID: 23985008.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    39. Tissue slice grafts of human renal cell carcinoma: an authentic preclinical model with high engraftment rate and metastatic potential. Urol Oncol. 2014 Jan; 32(1):43.e23-30. Thong AE, Zhao H, Ingels A, Valta MP, Nolley R, Santos J, Young SR, Peehl DM. PMID: 23911681.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    40. Establishment and serial passage of cell cultures derived from LuCaP xenografts. Prostate. 2013 Sep; 73(12):1251-62. Young SR, Saar M, Santos J, Nguyen HM, Vessella RL, Peehl DM. PMID: 23740600.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    41. Induced pluripotency of human prostatic epithelial cells. PLoS One. 2013; 8(5):e64503. Zhao H, Sun N, Young SR, Nolley R, Santos J, Wu JC, Peehl DM. PMID: 23717621.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    42. Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. Prostate. 2013 Aug; 73(11):1171-81. Keshari KR, Sriram R, Van Criekinge M, Wilson DM, Wang ZJ, Vigneron DB, Peehl DM, Kurhanewicz J. PMID: 23532911.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    43. Anti-Oligomannose Antibodies as Potential Serum Biomarkers of Aggressive Prostate Cancer. Drug Dev Res. 2013 Mar; 74(2):65-80. Wang D, Dafik L, Nolley R, Huang W, Wolfinger RD, Wang LX, Peehl DM. PMID: 25152555.
      View in: PubMed   Mentions: 12     Fields:    
    44. Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation. J Clin Endocrinol Metab. 2013 Mar; 98(3):E586-94. Wang Y, Radhakrishnan D, He X, Peehl DM, Eng C. PMID: 23386643.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    45. Transcript levels of androgen receptor variant AR-V1 or AR-V7 do not predict recurrence in patients with prostate cancer at indeterminate risk for progression. J Urol. 2012 Dec; 188(6):2158-64. Zhao H, Coram MA, Nolley R, Reese SW, Young SR, Peehl DM. PMID: 23088973.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    46. Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer. Clin Cancer Res. 2012 Jun 15; 18(12):3366-76. Tian J, Zhao H, Nolley R, Reese SW, Young SR, Li X, Peehl DM, Knox SJ. PMID: 22535156.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    47. Microfluidic integration for automated targeted proteomic assays. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):5972-7. Hughes AJ, Lin RK, Peehl DM, Herr AE. PMID: 22474344.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    48. Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):4945-50. Hubbard SC, Boyce M, McVaugh CT, Peehl DM, Bertozzi CR. PMID: 21798741.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    49. DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer. Genome Res. 2011 Jul; 21(7):1017-27. Kobayashi Y, Absher DM, Gulzar ZG, Young SR, McKenney JK, Peehl DM, Brooks JD, Myers RM, Sherlock G. PMID: 21521786.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    50. Stiffness mapping prostate biopsy samples using a tactile sensor. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:8515-8. Peng Q, Omata S, Peehl DM, Constantinou CE. PMID: 22256325.
      View in: PubMed   Mentions:
    51. Serum Mac-2BP does not distinguish men with high grade, large volume prostate cancer from men with benign prostatic hyperplasia. Prostate. 2011 Jan 01; 71(1):26-31. Peehl DM, Chen Z, Nolley R. PMID: 20583127.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    52. Anti-tumor and radiosensitization activities of the iron chelator HDp44mT are mediated by effects on intracellular redox status. Cancer Lett. 2010 Dec 08; 298(2):231-7. Tian J, Peehl DM, Zheng W, Knox SJ. PMID: 20678860.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    53. Metalloporphyrin synergizes with ascorbic acid to inhibit cancer cell growth through fenton chemistry. Cancer Biother Radiopharm. 2010 Aug; 25(4):439-48. Tian J, Peehl DM, Knox SJ. PMID: 20735206.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    54. Tissue slice grafts: an in vivo model of human prostate androgen signaling. Am J Pathol. 2010 Jul; 177(1):229-39. Zhao H, Nolley R, Chen Z, Peehl DM. PMID: 20472887.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    55. Targeting monoamine oxidase A in advanced prostate cancer. J Cancer Res Clin Oncol. 2010 Nov; 136(11):1761-71. Flamand V, Zhao H, Peehl DM. PMID: 20204405.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    56. Methods for metabolic evaluation of prostate cancer cells using proton and (13)C HR-MAS spectroscopy and [3-(13)C] pyruvate as a metabolic substrate. Magn Reson Med. 2009 Nov; 62(5):1091-8. Levin YS, Albers MJ, Butler TN, Spielman D, Peehl DM, Kurhanewicz J. PMID: 19780158.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    57. Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20; 2:55. Zhao H, Flamand V, Peehl DM. PMID: 19691856.
      View in: PubMed   Mentions: 15     Fields:    
    58. Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblasts. Prostate. 2009 Jun 15; 69(9):991-1000. Zhao H, Peehl DM. PMID: 19267366.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    59. Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients. Int J Cancer. 2009 May 01; 124(9):2050-9. Swami S, Krishnan AV, Moreno J, Bhattacharyya RS, Gardner C, Brooks JD, Peehl DM, Feldman D. PMID: 19127598.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    60. The significance of monoamine oxidase-A expression in high grade prostate cancer. J Urol. 2008 Nov; 180(5):2206-11. Peehl DM, Coram M, Khine H, Reese S, Nolley R, Zhao H. PMID: 18804811.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    61. Association of prostate-specific antigen promoter genotype with clinical and histopathologic features of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2008 Sep; 17(9):2451-7. Cramer SD, Sun J, Zheng SL, Xu J, Peehl DM. PMID: 18768516.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    62. Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. Cancer Res. 2008 Aug 15; 68(16):6831-9. Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D. PMID: 18701509.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    63. Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level. Cancer Res. 2008 Aug 01; 68(15):6306-12. Das S, Hahn Y, Walker DA, Nagata S, Willingham MC, Peehl DM, Bera TK, Lee B, Pastan I. PMID: 18676855.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    64. The current state of preclinical prostate cancer animal models. Prostate. 2008 May 01; 68(6):629-39. Pienta KJ, Abate-Shen C, Agus DB, Attar RM, Chung LW, Greenberg NM, Hahn WC, Isaacs JT, Navone NM, Peehl DM, Simons JW, Solit DB, Soule HR, VanDyke TA, Weber MJ, Wu L, Vessella RL. PMID: 18213636.
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    65. Inhibition of monoamine oxidase A promotes secretory differentiation in basal prostatic epithelial cells. Differentiation. 2008 Sep; 76(7):820-30. Zhao H, Nolley R, Chen Z, Reese SW, Peehl DM. PMID: 18248494.
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    66. Potentiation of the growth-inhibitory effects of vitamin D in prostate cancer by genistein. Nutr Rev. 2007 Aug; 65(8 Pt 2):S121-3. Krishnan AV, Swami S, Moreno J, Bhattacharyya RB, Peehl DM, Feldman D. PMID: 17867387.
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    67. Vitamin D inhibition of the prostaglandin pathway as therapy for prostate cancer. Nutr Rev. 2007 Aug; 65(8 Pt 2):S113-5. Feldman D, Krishnan A, Moreno J, Swami S, Peehl DM, Srinivas S. PMID: 17867384.
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    68. Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):694-702. Krishnan AV, Moreno J, Nonn L, Malloy P, Swami S, Peng L, Peehl DM, Feldman D. PMID: 17229571.
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    69. High resolution regional elasticity mapping of the human prostate. Annu Int Conf IEEE Eng Med Biol Soc. 2007; 2007:5803-6. Murayama Y, Omata S, Yajima T, Peng Q, Shishido K, Peehl DM, Constantinou CE. PMID: 18003332.
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    70. Distinctive gene expression of prostatic stromal cells cultured from diseased versus normal tissues. J Cell Physiol. 2007 Jan; 210(1):111-21. Zhao H, Ramos CF, Brooks JD, Peehl DM. PMID: 17044071.
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    71. Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer. J Nutr. 2007 01; 137(1 Suppl):205S-210S. Swami S, Krishnan AV, Moreno J, Bhattacharyya RB, Peehl DM, Feldman D. PMID: 17182827.
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    72. Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis. 2007 Jun; 28(6):1188-96. Nonn L, Duong D, Peehl DM. PMID: 17151092.
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    73. Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer. Endocrinology. 2006 Dec; 147(12):5806-16. Bauman DR, Steckelbroeck S, Peehl DM, Penning TM. PMID: 16959841.
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    74. Mechanisms of vitamin D-mediated growth inhibition in prostate cancer cells: inhibition of the prostaglandin pathway. Anticancer Res. 2006 Jul-Aug; 26(4A):2525-30. Moreno J, Krishnan AV, Peehl DM, Feldman D. PMID: 16886660.
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    75. Inhibition of p38 by vitamin D reduces interleukin-6 production in normal prostate cells via mitogen-activated protein kinase phosphatase 5: implications for prostate cancer prevention by vitamin D. Cancer Res. 2006 Apr 15; 66(8):4516-24. Nonn L, Peng L, Feldman D, Peehl DM. PMID: 16618780.
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    76. Expression of CCL5 (RANTES) and CCR5 in prostate cancer. Prostate. 2006 Feb 01; 66(2):124-34. Vaday GG, Peehl DM, Kadam PA, Lawrence DM. PMID: 16161154.
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    77. Comparative gene and protein expression in primary cultures of epithelial cells from benign prostatic hyperplasia and prostate cancer. Cancer Lett. 2005 Sep 28; 227(2):213-22. Rose A, Xu Y, Chen Z, Fan Z, Stamey TA, McNeal JE, Caldwell M, Peehl DM. PMID: 16112424.
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    78. Genistein potentiates the growth inhibitory effects of 1,25-dihydroxyvitamin D3 in DU145 human prostate cancer cells: role of the direct inhibition of CYP24 enzyme activity. Mol Cell Endocrinol. 2005 Sep 28; 241(1-2):49-61. Swami S, Krishnan AV, Peehl DM, Feldman D. PMID: 15955619.
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    79. Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease. Mol Endocrinol. 2006 Feb; 20(2):444-58. Bauman DR, Steckelbroeck S, Williams MV, Peehl DM, Penning TM. PMID: 16179381.
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    80. Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells. Cancer Res. 2005 Sep 01; 65(17):7917-25. Moreno J, Krishnan AV, Swami S, Nonn L, Peehl DM, Feldman D. PMID: 16140963.
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    81. Molecular targets of doxazosin in human prostatic stromal cells. Prostate. 2005 Mar 01; 62(4):400-10. Zhao H, Lai F, Nonn L, Brooks JD, Peehl DM. PMID: 15378519.
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    82. Redox modulation of human prostate carcinoma cells by selenite increases radiation-induced cell killing. Free Radic Biol Med. 2005 Jan 01; 38(1):50-7. Husbeck B, Peehl DM, Knox SJ. PMID: 15589371.
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    83. Interaction of nuclear receptor ligands with the Vitamin D signaling pathway in prostate cancer. J Steroid Biochem Mol Biol. 2004 Nov; 92(4):307-15. Peehl DM, Feldman D. PMID: 15663994.
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    84. Expression of transforming growth factor-beta 1 and growth in soft agar differentiate prostate carcinoma-associated fibroblasts from normal prostate fibroblasts. Int J Cancer. 2004 Nov 01; 112(2):213-8. San Francisco IF, DeWolf WC, Peehl DM, Olumi AF. PMID: 15352032.
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    85. Molecular and cellular pathogenesis of benign prostatic hyperplasia. J Urol. 2004 Nov; 172(5 Pt 1):1784-91. Lee KL, Peehl DM. PMID: 15540721.
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    86. Molecular activity of 1,25-dihydroxyvitamin D3 in primary cultures of human prostatic epithelial cells revealed by cDNA microarray analysis. J Steroid Biochem Mol Biol. 2004 Oct; 92(3):131-41. Peehl DM, Shinghal R, Nonn L, Seto E, Krishnan AV, Brooks JD, Feldman D. PMID: 15555907.
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    87. Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells. Oncogene. 2004 Sep 02; 23(40):6712-25. Khanim FL, Gommersall LM, Wood VH, Smith KL, Montalvo L, O'Neill LP, Xu Y, Peehl DM, Stewart PM, Turner BM, Campbell MJ. PMID: 15300237.
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    88. Mechanisms of decreased Vitamin D 1alpha-hydroxylase activity in prostate cancer cells. Mol Cell Endocrinol. 2004 Jun 30; 221(1-2):67-74. Ma JF, Nonn L, Campbell MJ, Hewison M, Feldman D, Peehl DM. PMID: 15223133.
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    89. Analysis of vitamin D-regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays. Prostate. 2004 May 15; 59(3):243-51. Krishnan AV, Shinghal R, Raghavachari N, Brooks JD, Peehl DM, Feldman D. PMID: 15042599.
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    90. Are primary cultures realistic models of prostate cancer? J Cell Biochem. 2004 Jan 01; 91(1):185-95. Peehl DM. PMID: 14689590.
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    91. Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol. 2003 Nov; 87(2-3):191-8. He XY, Yang YZ, Peehl DM, Lauderdale A, Schulz H, Yang SY. PMID: 14672739.
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    92. Elevated expression of inhibitor of apoptosis proteins in prostate cancer. Clin Cancer Res. 2003 Oct 15; 9(13):4914-25. Krajewska M, Krajewski S, Banares S, Huang X, Turner B, Bubendorf L, Kallioniemi OP, Shabaik A, Vitiello A, Peehl D, Gao GJ, Reed JC. PMID: 14581366.
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    93. Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells. Endocrinology. 2003 Jul; 144(7):2922-32. Rizner TL, Lin HK, Peehl DM, Steckelbroeck S, Bauman DR, Penning TM. PMID: 12810547.
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    94. Pathways mediating the growth-inhibitory actions of vitamin D in prostate cancer. J Nutr. 2003 07; 133(7 Suppl):2461S-2469S. Peehl DM, Krishnan AV, Feldman D. PMID: 12840225.
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    95. Primary culture model of peroxisome proliferator-activated receptor gamma activity in prostate cancer cells. J Cell Physiol. 2003 Jul; 196(1):131-43. Xu Y, Iyengar S, Roberts RL, Shappell SB, Peehl DM. PMID: 12767049.
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    96. Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells. Int J Cancer. 2003 May 20; 105(1):14-9. Moore MG, Wetterau LA, Francis MJ, Peehl DM, Cohen P. PMID: 12672024.
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    97. Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line. Prostate. 2003 Mar 01; 54(4):258-67. Lecane PS, Kiviharju TM, Sellers RG, Peehl DM. PMID: 12539224.
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    98. Inhibition of prostate cancer growth by vitamin D: Regulation of target gene expression. J Cell Biochem. 2003 Feb 01; 88(2):363-71. Krishnan AV, Peehl DM, Feldman D. PMID: 12520538.
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    99. The role of vitamin D in prostate cancer. Recent Results Cancer Res. 2003; 164:205-21. Krishnan AV, Peehl DM, Feldman D. PMID: 12899524.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    100. Growth of prostatic epithelial and stromal cells in vitro. Methods Mol Med. 2003; 81:41-57. Peehl DM. PMID: 12725113.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    101. Vitamin D receptor start codon polymorphism (FokI) and prostate cancer progression. Cancer Epidemiol Biomarkers Prev. 2003 Jan; 12(1):23-7. Xu Y, Shibata A, McNeal JE, Stamey TA, Feldman D, Peehl DM. PMID: 12540499.
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    102. Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells. J Urol. 2002 Oct; 168(4 Pt 1):1583-8. Peehl DM, Seto E, Hsu JY, Feldman D. PMID: 12352462.
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    103. Polymorphisms in the androgen receptor and type II 5 alpha-reductase genes and prostate cancer prognosis. Prostate. 2002 Sep 01; 52(4):269-78. Shibata A, Garcia MI, Cheng I, Stamey TA, McNeal JE, Brooks JD, Henderson S, Yemoto CE, Peehl DM. PMID: 12210487.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    104. Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin Cancer Res. 2002 Aug; 8(8):2666-74. Kiviharju TM, Lecane PS, Sellers RG, Peehl DM. PMID: 12171899.
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    105. Silencing of pi-class glutathione S-transferase in MDA PCa 2a and MDA PCa 2b cells. Prostate. 2002 Jun 01; 51(4):225-30. Vidanes GM, Paton V, Wallen E, Peehl DM, Navone N, Brooks JD. PMID: 11987150.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    106. A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer. Endocrinology. 2002 May; 143(5):1889-900. Krishnan AV, Zhao XY, Swami S, Brive L, Peehl DM, Ely KR, Feldman D. PMID: 11956172.
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    107. Expression of matrix metalloproteinase-2 and -9 and their inhibitors, tissue inhibitor of metalloproteinase-1 and -2, in primary cultures of human prostatic stromal and epithelial cells. J Cell Physiol. 2002 May; 191(2):208-16. Wilson MJ, Sellers RG, Wiehr C, Melamud O, Pei D, Peehl DM. PMID: 12064464.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    108. Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens. Cancer Res. 2002 Mar 15; 62(6):1654-61. Guo X, Knudsen BS, Peehl DM, Ruiz A, Bok D, Rando RR, Rhim JS, Nanus DM, Gudas LJ. PMID: 11912136.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    109. Cadmium-induced neoplastic transformation of human prostate epithelial cells. Int J Oncol. 2002 Mar; 20(3):543-7. Nakamura K, Yasunaga Y, Ko D, Xu LL, Moul JW, Peehl DM, Srivastava S, Rhim JS. PMID: 11836566.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
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