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Renuka Sriram, PhD

Title(s)Associate Researcher, Radiology
SchoolSchool of Medicine
Address1700 4th St
San Francisco CA 94158
Phone415-514-4874
ORCID ORCID Icon0000-0003-3505-2479 Additional info
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    Collapse Biography 
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    University of California, Davis, Davis, CA USAPh.D03/2008BioPhysics

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    Collapse Overview
    My research interests are primarily focused on the application of Magnetic Resonance technology to characterize the underlying metabolic dysregulation in pathologies and use them to develop clinically relevant markers for diagnostic and therapeutic purposes. Specifically, I’ve been engrossed with the application of hyperpolarized dissolution dynamic nuclear polarization MRI technique to urologic cancers; renal cell carcinoma and prostate cancer. Recently I've been exploring the differential metabolism of bacteria to develop specific imaging biomarkers infectious disease.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized 13C MRI Can Evaluate Early and Dose-Dependent Response to Radiation Therapy in a Prostate Cancer Mouse Model. Int J Radiat Oncol Biol Phys. 2020 Aug 01; 107(5):887-896. Qin H, Zhang V, Bok RA, Santos RD, Cunha JA, Hsu IC, Santos Bs JD, Lee JE, Sukumar S, Larson PEZ, Vigneron DB, Wilson DM, Sriram R, Kurhanewicz J. PMID: 32339646.
      View in: PubMed   Mentions:    Fields:    
    2. Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures. Cancers (Basel). 2020 Feb 26; 12(3). Sriram R, Van Criekinge M, DeLos Santos J, Ahamed F, Qin H, Nolley R, Santos RD, Tabatabai ZL, Bok RA, Keshari KR, Vigneron DB, Peehl DM, Kurhanewicz J. PMID: 32110965.
      View in: PubMed   Mentions:
    3. Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers. ACS Cent Sci. 2020 Feb 26; 6(2):155-165. Parker MFL, Luu JM, Schulte B, Huynh TL, Stewart MN, Sriram R, Yu MA, Jivan S, Turnbaugh PJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM. PMID: 32123733.
      View in: PubMed   Mentions:
    4. Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer. Oncotarget. 2019 Oct 22; 10(58):6096-6110. Korenchan DE, Bok R, Sriram R, Liu K, Santos RD, Qin H, Lobach I, Korn N, Wilson DM, Kurhanewicz J, Flavell RR. PMID: 31692908.
      View in: PubMed   Mentions:    Fields:    
    5. First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism. J Magn Reson. 2019 12; 309:106617. Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil MM, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB. PMID: 31648132.
      View in: PubMed   Mentions: 4     Fields:    
    6. Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13 C Magnetic Resonance Spectroscopy. Chemistry. 2019 Sep 12; 25(51):11842-11846. Wang S, Korenchan DE, Perez PM, Taglang C, Hayes TR, Sriram R, Bok R, Hong AS, Wu Y, Li H, Wang Z, Kurhanewicz J, Wilson DM, Flavell RR. PMID: 31338914.
      View in: PubMed   Mentions:    Fields:    
    7. Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging. Magn Reson Med. 2019 09; 82(3):959-972. Korenchan DE, Gordon JW, Subramaniam S, Sriram R, Baligand C, VanCriekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR. PMID: 31050049.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    8. Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography. ACS Cent Sci. 2019 Apr 24; 5(4):727-736. Muir RK, Zhao N, Wei J, Wang YH, Moroz A, Huang Y, Chen YC, Sriram R, Kurhanewicz J, Ruggero D, Renslo AR, Evans MJ. PMID: 31041393.
      View in: PubMed   Mentions:
    9. NMR quantification of lactate production and efflux and glutamate fractional enrichment in living human prostate biopsies cultured with [1,6-13 C2 ]glucose. Magn Reson Med. 2019 08; 82(2):566-576. Bancroft Brown J, Sriram R, VanCriekinge M, Delos Santos R, Sun J, Delos Santos J, Tabatabai ZL, Shinohara K, Nguyen H, Peehl DM, Kurhanewicz J. PMID: 30924180.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI. Cancers (Basel). 2019 Feb 22; 11(2). Bok R, Lee J, Sriram R, Keshari K, Sukumar S, Daneshmandi S, Korenchan DE, Flavell RR, Vigneron DB, Kurhanewicz J, Seth P. PMID: 30813322.
      View in: PubMed   Mentions:
    11. Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI. Cancers (Basel). 2018 Sep 05; 10(9). Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ. PMID: 30189677.
      View in: PubMed   Mentions:
    12. Assessing high-intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dual-agent imaging of metabolism and perfusion. NMR Biomed. 2019 10; 32(10):e3962. Lee JE, Diederich CJ, Bok R, Sriram R, Santos RD, Noworolski SM, Salgaonkar VA, Adams MS, Vigneron DB, Kurhanewicz J. PMID: 30022550.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. Molecular detection of inflammation in cell models using hyperpolarized 13C-pyruvate. Theranostics. 2018; 8(12):3400-3407. Sriram R, Nguyen J, Santos JD, Nguyen L, Sun J, Vigneron S, Van Criekinge M, Kurhanewicz J, MacKenzie JD. PMID: 29930738.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes. Sci Rep. 2018 05 21; 8(1):7928. Qin H, Carroll VN, Sriram R, Villanueva-Meyer JE, von Morze C, Wang ZJ, Mutch CA, Keshari KR, Flavell RR, Kurhanewicz J, Wilson DM. PMID: 29786697.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    15. Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI. Chem Commun (Camb). 2018 May 17; 54(41):5233-5236. Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR. PMID: 29726563.
      View in: PubMed   Mentions: 1     Fields:    
    16. [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism. ACS Infect Dis. 2018 07 13; 4(7):1067-1072. Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM. PMID: 29712422.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    17. Measuring glucocorticoid receptor expression in vivo with PET. Oncotarget. 2018 Apr 17; 9(29):20399-20408. Truillet C, Parker MFL, Huynh LT, Wei J, Jami KM, Wang YH, Shen YS, Sriram R, Wilson DM, Kurhanewicz J, Evans MJ. PMID: 29755660.
      View in: PubMed   Mentions:    Fields:    
    18. Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate. ACS Infect Dis. 2018 05 11; 4(5):797-805. Sriram R, Sun J, Villanueva-Meyer J, Mutch C, De Los Santos J, Peters J, Korenchan DE, Neumann K, Van Criekinge M, Kurhanewicz J, Rosenberg O, Wilson D, Ohliger MA. PMID: 29405697.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    19. PDTM-20. NONINVASIVE ASSESSMENT OF TREATMENT RESPONSE FOR DIFFUSE INTRINSIC PONTINE GLIOMA USING HYPERPOLARIZED 13C METABOLIC IMAGING. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi194-vi194. Ilwoo Park, Adam Autry, Xiaodong Yang, Yuying Zhai, Renuka Sriram, Dave Korenchan, John Kurhanewicz, Adam Cunha, I-Chow Hsu, Sarah Nelson, Sabine Mueller. .
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    20. Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. Sci Rep. 2017 08 11; 7(1):7903. Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM. PMID: 28801560.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    21. DIPG-16. NONINVASIVE ASSESSMENT OF TREATMENT RESPONSE FOR DIFFUSE INTRINSIC PONTINE GLIOMA USING HYPERPOLARIZED 13C METABOLIC IMAGING. Neuro-Oncology. 2017 Jun 1; 19(suppl_4):iv8-iv8. Ilwoo Park, Adam Elkhaled, Xiaodong Yang, Yuying Zhai, Renuka Sriram, Dave Korenchan, John Kurhanewicz, Adam Cunha, I-Chow Hsu, Sarah Nelson, Sabine Mueller. .
      View in: Publisher Site   Mentions:
    22. Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion. Cancer Res. 2017 06 15; 77(12):3207-3216. Chen HY, Larson PEZ, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J, Vigneron DB. PMID: 28428273.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    23. Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone. Magn Reson Med. 2017 01; 77(1):65-73. Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M. PMID: 27859575.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    24. PDTB-05. DEVELOPING A NONINVASIVE IMAGING MARKER FOR ASSESSING THE RESPONSE OF DIFFUSE INTRINSIC PONTINE GLIOMA TO PANOBINOSTAT USING HYPERPOLARIZED CARBON-13 MR METABOLIC IMAGING. Neuro-Oncology. 2016 Nov 1; 18(suppl_6):vi150-vi150. Ilwoo Park, Adam Elkhaled, Xiaodong Yang, Yuying Zhai, Renuka Sriram, Dave Korenchan, John Kurhanewicz, Sarah Nelson, Sabine Mueller. .
      View in: Publisher Site   Mentions:
    25. Separation of extra- and intracellular metabolites using hyperpolarized (13)C diffusion weighted MR. J Magn Reson. 2016 09; 270:115-123. Koelsch BL, Sriram R, Keshari KR, Leon Swisher C, Van Criekinge M, Sukumar S, Vigneron DB, Wang ZJ, Larson PEZ, Kurhanewicz J. PMID: 27434780.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    26. HG-117ASSESSING THE RESPONSE OF DIFFUSE INTRINSIC PONTINE GLIOMA TO PANOBINOSTAT USING HYPERPOLARIZED 13 C MAGNETIC RESONANCE METABOLIC IMAGING. Neuro-Oncology. 2016 Jun 1; 18(suppl 3):iii75.3-iii75. Ilwoo Park, Adam Elkhaled, Xiaodong Yang, Renuka Sriram, Dave Korenchan, John Kurhanewicz, Sarah Nelson, Sabine Mueller. .
      View in: Publisher Site   Mentions:
    27. Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance. Tomography. 2016 Mar; 2(1):35-42. Sriram R, Van Criekinge M, DeLos Santos J, Keshari KR, Wilson DM, Peehl D, Kurhanewicz J, Wang ZJ. PMID: 27227168.
      View in: PubMed   Mentions: 9     Fields:    
    28. Application of Good's buffers to pH imaging using hyperpolarized (13)C MRI. Chem Commun (Camb). 2015 Sep 25; 51(74):14119-22. Flavell RR, von Morze C, Blecha JE, Korenchan DE, Van Criekinge M, Sriram R, Gordon JW, Chen HY, Subramaniam S, Bok RA, Wang ZJ, Vigneron DB, Larson PE, Kurhanewicz J, Wilson DM. PMID: 26257040.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    29. Interaction of myoglobin with oleic acid. Chem Phys Lipids. 2015 Oct; 191:115-22. Shih L, Chung Y, Sriram R, Jue T. PMID: 26220615.
      View in: PubMed   Mentions: 6     Fields:    
    30. Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor. NMR Biomed. 2015 Sep; 28(9):1141-9. Sriram R, Van Criekinge M, Hansen A, Wang ZJ, Vigneron DB, Wilson DM, Keshari KR, Kurhanewicz J. PMID: 26202449.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    31. Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. Prostate. 2015 Oct; 75(14):1601-9. Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O'Brien T, Sampath D, Carano RA, Kurhanewicz J. PMID: 26177608.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    32. Dynamic UltraFast 2D EXchange SpectroscopY (UF-EXSY) of hyperpolarized substrates. J Magn Reson. 2015 Aug; 257:102-9. Leon Swisher C, Koelsch B, Sukumar S, Sriram R, Santos RD, Wang ZJ, Kurhanewicz J, Vigneron D, Larson P. PMID: 26117655.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    33. Hyperpolarized Carbon-13 MRI and MRS Studies. eMagRes. 2014 Dec 15; 311-324. Renuka Sriram, John Kurhanewicz, Daniel B. Vigneron. .
      View in: Publisher Site   Mentions:
    34. Hyperpolarized 13C MR Markers of Renal Tumor Aggressiveness. . 2013 Oct 1. Renuka Sriram, Betty Diamond. .
      View in: Publisher Site   Mentions:
    35. Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. Prostate. 2013 Aug; 73(11):1171-81. Keshari KR, Sriram R, Van Criekinge M, Wilson DM, Wang ZJ, Vigneron DB, Peehl DM, Kurhanewicz J. PMID: 23532911.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    36. Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas. Cancer Res. 2013 Jan 15; 73(2):529-38. Keshari KR, Sriram R, Koelsch BL, Van Criekinge M, Wilson DM, Kurhanewicz J, Wang ZJ. PMID: 23204238.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    37. Imaging apolipoprotein AI in vivo. NMR Biomed. 2011 Aug; 24(7):916-24. Sriram R, Lagerstedt JO, Petrlova J, Samardzic H, Kreutzer U, Xie H, Kaysen GA, Desreux JF, Thonon D, Jacques V, Van Loan M, Rutledge JC, Oda MN, Voss JC, Jue T. PMID: 21264979.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    38. Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510). Neuroimage. 2011 Feb 14; 54(4):2652-8. Yang D, Xie Z, Stephenson D, Morton D, Hicks CD, Brown TM, Sriram R, O'Neill S, Raunig D, Bocan T. PMID: 21035554.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    39. Targeting Apolipoproteins in Magnetic Resonance Imaging. Biomembrane Frontiers. 2009 Jan 1; 285-297. Renuka Sriram, Jens O. Lagerstedt, Haris Samardzic, Ulrike Kreutzer, Jitka Petrolova, Hongtao Xie, George A. Kaysen, John C. Voss, Jean F. Desreux, Thomas Jue. .
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    40. Determination of myoglobin concentration in blood-perfused tissue. Eur J Appl Physiol. 2008 Sep; 104(1):41-8. Masuda K, Truscott K, Lin PC, Kreutzer U, Chung Y, Sriram R, Jue T. PMID: 18516616.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
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