Dounia Le Guillou, PhD

Title(s)Specialist, Medicine
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #1401
San Francisco CA 94143
Phone415-502-0838
PronounsShe/Her/Hers
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Predicting Metabolic Dysfunction Associated Steatotic Liver Disease Risk Using Patient-Derived Induced Pluripotent Stem Cells. bioRxiv. 2025 Jan 15. Qin Y, Chhetri P, Theusch E, Lim G, Teker S, Kuang YL, Aziziraftar SK, Mehraban MH, Munoz-Howell A, Saxena V, Le Guillou D, Mattis AN, Maher JJ, Medina MW. PMID: 39868283; PMCID: PMC11761521.
      View in: PubMed   Mentions:
    2. Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis. Nat Rev Gastroenterol Hepatol. 2023 10; 20(10):662-678. Sharma S, Le Guillou D, Chen JY. PMID: 37679454.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    3. Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages. Nat Commun. 2023 07 03; 14(1):3902. Groeger M, Matsuo K, Heidary Arash E, Pereira A, Le Guillou D, Pino C, Telles-Silva KA, Maher JJ, Hsiao EC, Willenbring H. PMID: 37400454; PMCID: PMC10318012.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. The Role of STING in Liver Injury Is Both Stimulus- and Time-Dependent. Nutrients. 2022 Sep 28; 14(19). Siao K, Le Guillou D, Maher JJ, Duwaerts CC. PMID: 36235681; PMCID: PMC9572800.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    5. Induced Pluripotent Stem Cell-derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile. Gastroenterology. 2021 06; 160(7):2591-2594.e6. Duwaerts CC, Le Guillou D, Her CL, Phillips NJ, Willenbring H, Mattis AN, Maher JJ. PMID: 33640436; PMCID: PMC8169560.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    6. Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 04; 37(2):151-175. Allard J, Bucher S, Massart J, Ferron PJ, Le Guillou D, Loyant R, Daniel Y, Launay Y, Buron N, Begriche K, Borgne-Sanchez A, Fromenty B. PMID: 32535746; PMCID: PMC8012331.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    7. Drug-induced liver injury in obesity and nonalcoholic fatty liver disease. Adv Pharmacol. 2019; 85:75-107. Allard J, Le Guillou D, Begriche K, Fromenty B. PMID: 31307592.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    8. Endotoxin regulates matrix genes increasing reactive oxygen species generation by intercellular communication between palmitate-treated hepatocyte and stellate cell. J Cell Physiol. 2018 01; 234(1):122-133. Dornas W, Glaise D, Bodin A, Sharanek A, Burban A, Le Guillou D, Robert S, Dutertre S, Aninat C, Corlu A, Lagente V. PMID: 30191979.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure. Oxid Med Cell Longev. 2018; 2018:4396403. Bucher S, Le Guillou D, Allard J, Pinon G, Begriche K, Tête A, Sergent O, Lagadic-Gossmann D, Fromenty B. PMID: 30147834; PMCID: PMC6083493.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    10. Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells. J Pharmacol Exp Ther. 2018 06; 365(3):711-726. Le Guillou D, Bucher S, Begriche K, Hoët D, Lombès A, Labbe G, Fromenty B. PMID: 29669730.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    11. Co-exposure to benzo[a]pyrene and ethanol induces a pathological progression of liver steatosis in vitro and in vivo. Sci Rep. 2018 04 13; 8(1):5963. Bucher S, Tête A, Podechard N, Liamin M, Le Guillou D, Chevanne M, Coulouarn C, Imran M, Gallais I, Fernier M, Hamdaoui Q, Robin MA, Sergent O, Fromenty B, Lagadic-Gossmann D. PMID: 29654281; PMCID: PMC5899096.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    12. Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure. Environ Toxicol. 2017 Mar; 32(3):1024-1036. Bucher S, Jalili P, Le Guillou D, Begriche K, Rondel K, Martinais S, Zalko D, Corlu A, Robin MA, Fromenty B. PMID: 27322340.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsPHPublic Health
    13. A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen. Toxicol Appl Pharmacol. 2016 Feb 01; 292:40-55. Michaut A, Le Guillou D, Moreau C, Bucher S, McGill MR, Martinais S, Gicquel T, Morel I, Robin MA, Jaeschke H, Fromenty B. PMID: 26739624; PMCID: PMC4904302.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    14. Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice. Toxicol Appl Pharmacol. 2014 Apr 01; 276(1):63-72. Anthérieu S, Le Guillou D, Coulouarn C, Begriche K, Trak-Smayra V, Martinais S, Porceddu M, Robin MA, Fromenty B. PMID: 24525044.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    15. Relationships between radial glial progenitors and 5-HT neurons in the paraventricular organ of adult zebrafish - potential effects of serotonin on adult neurogenesis. Eur J Neurosci. 2013 Nov; 38(9):3292-301. Pérez MR, Pellegrini E, Cano-Nicolau J, Gueguen MM, Menouer-Le Guillou D, Merot Y, Vaillant C, Somoza GM, Kah O. PMID: 23981075.
      View in: PubMed   Mentions: 17  Translation:AnimalsCells
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