Loading...

Holger Willenbring, MD, PhD

Title(s)Professor, Surgery
SchoolSchool of Medicine
Phone415-476-2417
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Microphysiological systems to interrogate the Islet-Liver-Adipose Axis in normal physiology and Type-2 Diabetes Mellitus
    NIH/NIDDK UG3DK120004Sep 20, 2018 - Jul 31, 2020
    Role: Co-Principal Investigator
    Targeting AAV vectors to cell types involved in alcohol-induced liver injury
    NIH/NIAAA R01AA026578Sep 1, 2018 - May 31, 2023
    Role: Principal Investigator
    Building a functional biliary system from hepatocytes
    NIH/NIDDK R01DK107553Sep 1, 2016 - Jul 31, 2021
    Role: Co-Principal Investigator
    Myofibroblast-to-hepatocyte conversion as a therapy for alcoholic liver disease
    NIH/NIAAA R21AA022158Sep 1, 2013 - Aug 31, 2015
    Role: Principal Investigator
    Liver regeneration with stems cells of uniparental origin
    NIH/NIDDK R01DK080852Apr 1, 2008 - Aug 31, 2013
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Huck I, Gunewardena S, Espanol-Suner R, Willenbring H, Apte U. Hepatocyte Nuclear Factor 4 Alpha Activation Is Essential for Termination of Liver Regeneration in Mice. Hepatology. 2018 Dec 05. PMID: 30520062.
      View in: PubMed
    2. Schaub JR, Huppert KA, Kurial SNT, Hsu BY, Cast AE, Donnelly B, Karns RA, Chen F, Rezvani M, Luu HY, Mattis AN, Rougemont AL, Rosenthal P, Huppert SS, Willenbring H. De novo formation of the biliary system by TGFß-mediated hepatocyte transdifferentiation. Nature. 2018 05; 557(7704):247-251. PMID: 29720662.
      View in: PubMed
    3. Abou-Alfa GK, Andersen JB, Chapman W, Choti M, Forbes SJ, Gores GJ, Hong TS, Harding JJ, Vander Heiden MG, Javle M, Kelley RK, Kwong LN, Lowery M, Merrell A, Miyabe K, Rhim A, Saha S, Sia D, Tanasanvimon S, Venook A, Valle JW, Walesky C, Whetstine J, Willenbring H, Zhu AX, Mayer D, Stanger BZ. Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference. J Gastrointest Oncol. 2016 Dec; 7(6):819-827. PMID: 28078106.
      View in: PubMed
    4. Rezvani M, Español-Suñer R, Malato Y, Dumont L, Grimm AA, Kienle E, Bindman JG, Wiedtke E, Hsu BY, Naqvi SJ, Schwabe RF, Corvera CU, Grimm D, Willenbring H. In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis. Cell Stem Cell. 2016 06 02; 18(6):809-16. PMID: 27257763.
      View in: PubMed
    5. Rezvani M, Grimm AA, Willenbring H. Assessing the therapeutic potential of lab-made hepatocytes. Hepatology. 2016 07; 64(1):287-94. PMID: 27014802.
      View in: PubMed
    6. Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT. Physiological ranges of matrix rigidity modulate primary mouse hepatocyte function in part through hepatocyte nuclear factor 4 alpha. Hepatology. 2016 07; 64(1):261-75. PMID: 26755329.
      View in: PubMed
    7. Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H. A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver. Hepatology. 2015 Jan; 61(1):141-52. PMID: 25131933.
      View in: PubMed
    8. Hentzschel F, Hammerschmidt-Kamper C, Börner K, Heiss K, Knapp B, Sattler JM, Kaderali L, Castoldi M, Bindman JG, Malato Y, Willenbring H, Mueller AK, Grimm D. AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites. Mol Ther. 2014 Dec; 22(12):2130-41. PMID: 25189739.
      View in: PubMed
    9. Schaub JR, Malato Y, Gormond C, Willenbring H. Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury. Cell Rep. 2014 Aug 21; 8(4):933-9. PMID: 25131204; PMCID: PMC4376310.
    10. Lee RH, Roll G, Nguyen V, Willenbring H, Tang Q, Kang SM, Stock PG. Failure to achieve normal metabolic response in non-obese diabetic mice and streptozotocin-induced diabetic mice after transplantation of primary murine hepatocytes electroporated with the human proinsulin gene (p3MTChins). Transplant Proc. 2014 Jul-Aug; 46(6):2002-6. PMID: 25131094.
      View in: PubMed
    11. Espejel S, Eckardt S, Harbell J, Roll GR, McLaughlin KJ, Willenbring H. Brief report: Parthenogenetic embryonic stem cells are an effective cell source for therapeutic liver repopulation. Stem Cells. 2014 Jul; 32(7):1983-8. PMID: 24740448.
      View in: PubMed
    12. Ng R, Wu H, Xiao H, Chen X, Willenbring H, Steer CJ, Song G. Inhibition of microRNA-24 expression in liver prevents hepatic lipid accumulation and hyperlipidemia. Hepatology. 2014 Aug; 60(2):554-64. PMID: 24677249.
      View in: PubMed
    13. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 2014 Apr 03; 508(7494):93-7. PMID: 24572354; PMCID: PMC4161230.
    14. Mitchell C, Willenbring H. Addendum: A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice. Nat Protoc. 2014; 9(6). PMID: 24874817.
      View in: PubMed
    15. Mathur A, Loskill P, Hong S, Lee J, Marcus SG, Dumont L, Conklin BR, Willenbring H, Lee LP, Healy KE. Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development. Stem Cell Res Ther. 2013; 4 Suppl 1:S14. PMID: 24565415; PMCID: PMC4029618.
    16. Lim L, Balakrishnan A, Huskey N, Jones KD, Jodari M, Ng R, Song G, Riordan J, Anderton B, Cheung ST, Willenbring H, Dupuy A, Chen X, Brown D, Chang AN, Goga A. MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer. Hepatology. 2014 Jan; 59(1):202-15. PMID: 23913442; PMCID: PMC3877416.
    17. Willenbring H, Soto-Gutierrez A. Transplantable liver organoids made from only three ingredients. Cell Stem Cell. 2013 Aug 01; 13(2):139-40. PMID: 23910079.
      View in: PubMed
    18. Ma X, Duan Y, Tschudy-Seney B, Roll G, Behbahan IS, Ahuja TP, Tolstikov V, Wang C, McGee J, Khoobyari S, Nolta JA, Willenbring H, Zern MA. Highly efficient differentiation of functional hepatocytes from human induced pluripotent stem cells. Stem Cells Transl Med. 2013 Jun; 2(6):409-19. PMID: 23681950; PMCID: PMC3673753.
    19. Willenbring H, Grompe M. A therapy for liver failure found in the JNK yard. Cell. 2013 Apr 11; 153(2):283-4. PMID: 23582318.
      View in: PubMed
    20. Fan B, Malato Y, Calvisi DF, Naqvi S, Razumilava N, Ribback S, Gores GJ, Dombrowski F, Evert M, Chen X, Willenbring H. Cholangiocarcinomas can originate from hepatocytes in mice. J Clin Invest. 2012 Aug; 122(8):2911-5. PMID: 22797301.
      View in: PubMed
    21. Mattis AN, Willenbring H. A ZFN/piggyBac step closer to autologous liver cell therapy. Hepatology. 2012 Jun; 55(6):2033-5. PMID: 22422378.
      View in: PubMed
    22. Ng R, Song G, Roll GR, Frandsen NM, Willenbring H. A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration. J Clin Invest. 2012 Mar; 122(3):1097-108. PMID: 22326957.
      View in: PubMed
    23. Rountree CB, Mishra L, Willenbring H. Stem cells in liver diseases and cancer: recent advances on the path to new therapies. Hepatology. 2012 Jan; 55(1):298-306. PMID: 22030746.
      View in: PubMed
    24. Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H. Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest. 2011 Dec; 121(12):4850-60. PMID: 22105172; PMCID: PMC3226005.
    25. Willenbring H. A simple code for installing hepatocyte function. Cell Stem Cell. 2011 Aug 05; 9(2):89-91. PMID: 21816357.
      View in: PubMed
    26. Eckardt S, McLaughlin KJ, Willenbring H. Mouse chimeras as a system to investigate development, cell and tissue function, disease mechanisms and organ regeneration. Cell Cycle. 2011 Jul 01; 10(13):2091-9. PMID: 21606677.
      View in: PubMed
    27. D'Alessio JA, Ng R, Willenbring H, Tjian R. Core promoter recognition complex changes accompany liver development. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):3906-11. PMID: 21368148.
      View in: PubMed
    28. Malato Y, Willenbring H. The MAP3K TAK1: a chock block to liver cancer formation. Hepatology. 2010 Oct; 52(4):1506-9. PMID: 20879030.
      View in: PubMed
    29. Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest. 2010 Sep; 120(9):3120-6. PMID: 20739754; PMCID: PMC2929736.
    30. Roll GR, Willenbring H. Transplanted nonviable human hepatocytes produce appreciable serum albumin levels in mice. Stem Cell Res. 2010 Nov; 5(3):267-70. PMID: 20829142.
      View in: PubMed
    31. Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY). 2010 Jul; 2(7):415-31. PMID: 20634564; PMCID: PMC2933889.
    32. Erker L, Azuma H, Lee AY, Guo C, Orloff S, Eaton L, Benedetti E, Jensen B, Finegold M, Willenbring H, Grompe M. Therapeutic liver reconstitution with murine cells isolated long after death. Gastroenterology. 2010 Sep; 139(3):1019-29. PMID: 20621682.
      View in: PubMed
    33. Song G, Sharma AD, Roll GR, Ng R, Lee AY, Blelloch RH, Frandsen NM, Willenbring H. MicroRNAs control hepatocyte proliferation during liver regeneration. Hepatology. 2010 May; 51(5):1735-43. PMID: 20432256; PMCID: PMC3108060.
    34. Willenbring H, Sharma AD, Vogel A, Lee AY, Rothfuss A, Wang Z, Finegold M, Grompe M. Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis. Cancer Cell. 2008 Jul 08; 14(1):59-67. PMID: 18598944.
      View in: PubMed
    35. Mitchell C, Willenbring H. A reproducible and well-tolerated method for 2/3 partial hepatectomy in mice. Nat Protoc. 2008; 3(7):1167-70. PMID: 18600221.
      View in: PubMed
    36. Ramalho-Santos M, Willenbring H. On the origin of the term "stem cell". Cell Stem Cell. 2007 Jun 07; 1(1):35-8. PMID: 18371332.
      View in: PubMed
    37. Bailey AS, Willenbring H, Jiang S, Anderson DA, Schroeder DA, Wong MH, Grompe M, Fleming WH. Myeloid lineage progenitors give rise to vascular endothelium. Proc Natl Acad Sci U S A. 2006 Aug 29; 103(35):13156-61. PMID: 16920790.
      View in: PubMed
    38. Rizvi AZ, Swain JR, Davies PS, Bailey AS, Decker AD, Willenbring H, Grompe M, Fleming WH, Wong MH. Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6321-5. PMID: 16606845; PMCID: PMC1435365.
    39. Vogel A, Aslan JE, Willenbring H, Klein C, Finegold M, Mount H, Thomas G, Grompe M. Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases. Gastroenterology. 2006 Jan; 130(1):104-19. PMID: 16401474; PMCID: PMC1424224.
    40. Held PK, Al-Dhalimy M, Willenbring H, Akkari Y, Jiang S, Torimaru Y, Olson S, Fleming WH, Finegold M, Grompe M. In vivo genetic selection of renal proximal tubules. Mol Ther. 2006 Jan; 13(1):49-58. PMID: 16216560.
      View in: PubMed
    41. Willenbring H. Therapeutic cell fusion. Br J Surg. 2005 Aug; 92(8):923-4. PMID: 16034848.
      View in: PubMed
    42. Willenbring H, Grompe M. Delineating the hepatocyte's hematopoietic fusion partner. Cell Cycle. 2004 Dec; 3(12):1489-91. PMID: 15611666.
      View in: PubMed
    43. Willenbring H, Bailey AS, Foster M, Akkari Y, Dorrell C, Olson S, Finegold M, Fleming WH, Grompe M. Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. Nat Med. 2004 Jul; 10(7):744-8. PMID: 15195088.
      View in: PubMed
    44. Willenbring H, Grompe M. Embryonic versus adult stem cell pluripotency: in liver only fusion matters. J Assist Reprod Genet. 2003 Oct; 20(10):393-4. PMID: 14649377.
      View in: PubMed
    45. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature. 2003 Apr 24; 422(6934):897-901. PMID: 12665832.
      View in: PubMed
    46. Linnebank M, Tschiedel E, Häberle J, Linnebank A, Willenbring H, Kleijer WJ, Koch HG. Argininosuccinate lyase (ASL) deficiency: mutation analysis in 27 patients and a completed structure of the human ASL gene. Hum Genet. 2002 Oct; 111(4-5):350-9. PMID: 12384776.
      View in: PubMed
    47. Homberger A, Linnebank M, Winter C, Willenbring H, Marquardt T, Harms E, Koch HG. Genomic structure and transcript variants of the human methylenetetrahydrofolate reductase gene. Eur J Hum Genet. 2000 Sep; 8(9):725-9. PMID: 10980581.
      View in: PubMed
    48. Poremba C, Willenbring H, Hero B, Christiansen H, Schäfer KL, Brinkschmidt C, Jürgens H, Böcker W, Dockhorn-Dworniczak B. Telomerase activity distinguishes between neuroblastomas with good and poor prognosis. Ann Oncol. 1999 Jun; 10(6):715-21. PMID: 10442195.
      View in: PubMed
    49. Poremba C, Böcker W, Willenbring H, Schäfer KL, Otterbach F, Bürger H, Diallo R, Dockhorn-Dworniczak B. Telomerase activity in human proliferative breast lesions. Int J Oncol. 1998 Mar; 12(3):641-8. PMID: 9472105.
      View in: PubMed
    50. Hiort O, Sinnecker GH, Willenbring H, Lehners A, Zöllner A, Struve D. Nonisotopic single strand conformation analysis of the 5 alpha-reductase type 2 gene for the diagnosis of 5 alpha-reductase deficiency. J Clin Endocrinol Metab. 1996 Sep; 81(9):3415-8. PMID: 8784107.
      View in: PubMed
    51. Hiort O, Willenbring H, Albers N, Hecker W, Engert J, Dibbelt L, Sinnecker GH. Molecular genetic analysis and human chorionic gonadotropin stimulation tests in the diagnosis of prepubertal patients with partial 5 alpha-reductase deficiency. Eur J Pediatr. 1996 Jun; 155(6):445-51. PMID: 8789759.
      View in: PubMed