Elizabeth Theusch

Title(s)Assistant Researcher, Pediatrics
SchoolSchool of Medicine
Address5700 Martin Luther King Jr Way
Oakland CA 94609
ORCID ORCID Icon0000-0002-5678-759X Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Wisconsin-Madison, Madison, WIB.S.2005Genetics and Biochemistry
    City College of San Francisco, San Francisco, CACertificate2009Computer Programming: C++
    University of California, San Francisco, San Francisco, CAPh.D.2010Biomedical Sciences
    Children's Hospital Oakland Research Institute (CHORI), Oakland, CAPostdoctoral2016Computational Biology

    Collapse Overview 
    Collapse Overview
    As a computational biologist with training in human genetics and molecular biology, my recent projects have focused on studying statin pharmacogenomics and transcriptomics, cholesterol metabolism, and cardiovascular disease. I am especially passionate about studying sex and genetic ancestry differences in disease risk, normal metabolism, and drug response.

    Collapse Research 
    Collapse Research Activities and Funding
    Genetic Regulation of Nonalcoholic Fatty Liver Disease
    NIH R01DK130391Jun 8, 2021 - Mar 31, 2025
    Role: Co-Investigator
    Functional Dissection of the 19p13.11 Haplotype
    NIH R56HL132088Sep 15, 2016 - Aug 31, 2017
    Role: Co-Investigator
    Pharmacogenomics of Statin Therapy
    NIH P50GM115318Sep 7, 2015 - Aug 31, 2021
    Role: Co-Investigator
    Genetic variation influencing in vitro statin-induced changes in gene expression and in vivo statin response
    AHA Postdoctoral Fellowship 15POST21880006Jan 1, 2015 - Mar 31, 2016
    Role: Principal Investigator
    Statin-induced changes in gene transcript structure assessed by RNA-Seq
    AHA Postdoctoral Fellowship 12POST10430005Jul 1, 2012 - Sep 30, 2014
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts. Nat Genet. 2021 07; 53(7):972-981. Veturi Y, Lucas A, Bradford Y, Hui D, Dudek S, Theusch E, Verma A, Miller JE, Kullo I, Hakonarson H, Sleiman P, Schaid D, Stein CM, Edwards DRV, Feng Q, Wei WQ, Medina MW, Krauss RM, Hoffmann TJ, Risch N, Voight BF, Rader DJ, Ritchie MD. PMID: 34140684.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    2. Inclusion through part-time science. Science. 2021 May 07; 372(6542):582. Theusch E. PMID: 33958468.
      View in: PubMed   Mentions:    Fields:    
    3. Identifying genetic modulators of statin response using subject-derived lymphoblastoid cell lines. Pharmacogenomics. 2021 05; 22(7):413-421. Kuang YL, Theusch E, M Krauss R, W Medina M. PMID: 33858191.
      View in: PubMed   Mentions:    Fields:    
    4. A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus. Commun Biol. 2021 03 01; 4(1):266. Hardcastle AJ, Liskova P, Bykhovskaya Y, McComish BJ, Davidson AE, Inglehearn CF, Li X, Choquet H, Habeeb M, Lucas SEM, Sahebjada S, Pontikos N, Lopez KER, Khawaja AP, Ali M, Dudakova L, Skalicka P, Van Dooren BTH, Geerards AJM, Haudum CW, Faro VL, Tenen A, Simcoe MJ, Patasova K, Yarrand D, Yin J, Siddiqui S, Rice A, Farraj LA, Chen YI, Rahi JS, Krauss RM, Theusch E, Charlesworth JC, Szczotka-Flynn L, Toomes C, Meester-Smoor MA, Richardson AJ, Mitchell PA, Taylor KD, Melles RB, Aldave AJ, Mills RA, Cao K, Chan E, Daniell MD, Wang JJ, Rotter JI, Hewitt AW, MacGregor S, Klaver CCW, Ramdas WD, Craig JE, Iyengar SK, O'Brart D, Jorgenson E, Baird PN, Rabinowitz YS, Burdon KP, Hammond CJ, Tuft SJ, Hysi PG. PMID: 33649486.
      View in: PubMed   Mentions:
    5. Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines. BMC Genomics. 2020 Aug 12; 21(1):555. Theusch E, Chen YI, Rotter JI, Krauss RM, Medina MW. PMID: 32787775.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Statin-induced LDL cholesterol response and type 2 diabetes: a bidirectional two-sample Mendelian randomization study. Pharmacogenomics J. 2020 06; 20(3):462-470. Smit RAJ, Trompet S, Leong A, Goodarzi MO, Postmus I, Warren H, Theusch E, Barnes MR, Arsenault BJ, Li X, Feng Q, Chasman DI, Cupples LA, Hitman GA, Krauss RM, Psaty BM, Rotter JI, Cessie SL, Stein CM, Jukema JW, GIST consortium . PMID: 31801993.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    7. GeneFishing to reconstruct context specific portraits of biological processes. Proc Natl Acad Sci U S A. 2019 09 17; 116(38):18943-18950. Liu K, Theusch E, Zhou Y, Ashuach T, Dose AC, Bickel PJ, Medina MW, Huang H. PMID: 31484776.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. ZNF542P is a pseudogene associated with LDL response to simvastatin treatment. Sci Rep. 2018 08 20; 8(1):12443. Kim K, Theusch E, Kuang YL, Dose A, Mitchel K, Cubitt C, Chen YI, Krauss RM, Medina MW. PMID: 30127457.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsCTClinical Trials
    9. A large electronic-health-record-based genome-wide study of serum lipids. Nat Genet. 2018 03; 50(3):401-413. Hoffmann TJ, Theusch E, Haldar T, Ranatunga DK, Jorgenson E, Medina MW, Kvale MN, Kwok PY, Schaefer C, Krauss RM, Iribarren C, Risch N. PMID: 29507422.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    10. Generalized correlation measure using count statistics for gene expression data with ordered samples. Bioinformatics. 2018 02 15; 34(4):617-624. Wang YXR, Liu K, Theusch E, Rotter JI, Medina MW, Waterman MS, Huang H, Stegle O. PMID: 29040382.
      View in: PubMed   Mentions: 4     Fields:    
    11. Human genetic variation in VAC14 regulates Salmonella invasion and typhoid fever through modulation of cholesterol. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7746-E7755. Alvarez MI, Glover LC, Luo P, Wang L, Theusch E, Oehlers SH, Walton EM, Tram TTB, Kuang YL, Rotter JI, McClean CM, Chinh NT, Medina MW, Tobin DM, Dunstan SJ, Ko DC. PMID: 28827342.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    12. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet. 2016 10; 48(10):1171-1184. Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N, Kristiansson K, Shah S, Kleber ME, Guo X, Lyytikäinen LP, Fava C, Eriksson N, Nolte IM, Magnusson PK, Salfati EL, Rallidis LS, Theusch E, Smith AJP, Folkersen L, Witkowska K, Pers TH, Joehanes R, Kim SK, Lataniotis L, Jansen R, Johnson AD, Warren H, Kim YJ, Zhao W, Wu Y, Tayo BO, Bochud M, CHARGE-EchoGen consortium , CHARGE-HF consortium , Wellcome Trust Case Control Consortium , Absher D, Adair LS, Amin N, Arking DE, Axelsson T, Baldassarre D, Balkau B, Bandinelli S, Barnes MR, Barroso I, Bevan S, Bis JC, Bjornsdottir G, Boehnke M, Boerwinkle E, Bonnycastle LL, Boomsma DI, Bornstein SR, Brown MJ, Burnier M, Cabrera CP, Chambers JC, Chang IS, Cheng CY, Chines PS, Chung RH, Collins FS, Connell JM, Döring A, Dallongeville J, Danesh J, de Faire U, Delgado G, Dominiczak AF, Doney ASF, Drenos F, Edkins S, Eicher JD, Elosua R, Enroth S, Erdmann J, Eriksson P, Esko T, Evangelou E, Evans A, Fall T, Farrall M, Felix JF, Ferrières J, Ferrucci L, Fornage M, Forrester T, Franceschini N, Duran OHF, Franco-Cereceda A, Fraser RM, Ganesh SK, Gao H, Gertow K, Gianfagna F, Gigante B, Giulianini F, Goel A, Goodall AH, Goodarzi MO, Gorski M, Gräßler J, Groves C, Gudnason V, Gyllensten U, Hallmans G, Hartikainen AL, Hassinen M, Havulinna AS, Hayward C, Hercberg S, Herzig KH, Hicks AA, Hingorani AD, Hirschhorn JN, Hofman A, Holmen J, Holmen OL, Hottenga JJ, Howard P, Hsiung CA, Hunt SC, Ikram MA, Illig T, Iribarren C, Jensen RA, Kähönen M, Kang H, Kathiresan S, Keating BJ, Khaw KT, Kim YK, Kim E, Kivimaki M, Klopp N, Kolovou G, Komulainen P, Kooner JS, Kosova G, Krauss RM, Kuh D, Kutalik Z, Kuusisto J, Kvaløy K, Lakka TA, Lee NR, Lee IT, Lee WJ, Levy D, Li X, Liang KW, Lin H, Lin L, Lindström J, Lobbens S, Männistö S, Müller G, Müller-Nurasyid M, Mach F, Markus HS, Marouli E, McCarthy MI, McKenzie CA, Meneton P, Menni C, Metspalu A, Mijatovic V, Moilanen L, Montasser ME, Morris AD, Morrison AC, Mulas A, Nagaraja R, Narisu N, Nikus K, O'Donnell CJ, O'Reilly PF, Ong KK, Paccaud F, Palmer CD, Parsa A, Pedersen NL, Penninx BW, Perola M, Peters A, Poulter N, Pramstaller PP, Psaty BM, Quertermous T, Rao DC, Rasheed A, Rayner NWNWR, Renström F, Rettig R, Rice KM, Roberts R, Rose LM, Rossouw J, Samani NJ, Sanna S, Saramies J, Schunkert H, Sebert S, Sheu WH, Shin YA, Sim X, Smit JH, Smith AV, Sosa MX, Spector TD, Stancáková A, Stanton A, Stirrups KE, Stringham HM, Sundstrom J, Swift AJ, Syvänen AC, Tai ES, Tanaka T, Tarasov KV, Teumer A, Thorsteinsdottir U, Tobin MD, Tremoli E, Uitterlinden AG, Uusitupa M, Vaez A, Vaidya D, van Duijn CM, van Iperen EPA, Vasan RS, Verwoert GC, Virtamo J, Vitart V, Voight BF, Vollenweider P, Wagner A, Wain LV, Wareham NJ, Watkins H, Weder AB, Westra HJ, Wilks R, Wilsgaard T, Wilson JF, Wong TY, Yang TP, Yao J, Yengo L, Zhang W, Zhao JH, Zhu X, Bovet P, Cooper RS, Mohlke KL, Saleheen D, Lee JY, Elliott P, Gierman HJ, Willer CJ, Franke L, Hovingh GK, Taylor KD, Dedoussis G, Sever P, Wong A, Lind L, Assimes TL, Njølstad I, Schwarz PE, Langenberg C, Snieder H, Caulfield MJ, Melander O, Laakso M, Saltevo J, Rauramaa R, Tuomilehto J, Ingelsson E, Lehtimäki T, Hveem K, Palmas W, März W, Kumari M, Salomaa V, Chen YI, Rotter JI, Froguel P, Jarvelin MR, Lakatta EG, Kuulasmaa K, Franks PW, Hamsten A, Wichmann HE, Palmer CNA, Stefansson K, Ridker PM, Loos RJF, Chakravarti A, Deloukas P, Morris AP, Newton-Cheh C, Munroe PB. PMID: 27618452.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    13. SUGP1 is a novel regulator of cholesterol metabolism. Hum Mol Genet. 2016 07 15; 25(14):3106-3116. Kim MJ, Yu CY, Theusch E, Naidoo D, Stevens K, Kuang YL, Schuetz E, Chaudhry AS, Medina MW. PMID: 27206982.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. RP1-13D10.2 Is a Novel Modulator of Statin-Induced Changes in Cholesterol. Circ Cardiovasc Genet. 2016 Jun; 9(3):223-30. Mitchel K, Theusch E, Cubitt C, Dosé AC, Stevens K, Naidoo D, Medina MW. PMID: 27071970.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner. Pharmacogenomics J. 2017 06; 17(3):222-229. Theusch E, Kim K, Stevens K, Smith JD, Chen YI, Rotter JI, Nickerson DA, Medina MW. PMID: 26927283.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. Pharmacogenomics J. 2017 03; 17(2):137-145. Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, Weiss ST, Kroetz DL, Sadee W, Nickerson DA, Krauss RM, George AL, Schuetz EG, Medina MW, Cox NJ, Scherer SE, Giacomini KM, Brenner SE. PMID: 26856248.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    17. Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations. J Cardiovasc Pharmacol. 2015 Jul; 66(1):80-5. Luzum JA, Theusch E, Taylor KD, Wang A, Sadee W, Binkley PF, Krauss RM, Medina MW, Kitzmiller JP. PMID: 26164721.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    18. Ancestry and other genetic associations with plasma PCSK9 response to simvastatin. Pharmacogenet Genomics. 2014 Oct; 24(10):492-500. Theusch E, Medina MW, Rotter JI, Krauss RM. PMID: 25089948.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCTClinical Trials
    19. Prediction of LDL cholesterol response to statin using transcriptomic and genetic variation. Genome Biol. 2014 Sep 30; 15(9):460. Kim K, Bolotin E, Theusch E, Huang H, Medina MW, Krauss RM. PMID: 25316374.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1917-23. Medina MW, Bauzon F, Naidoo D, Theusch E, Stevens K, Schilde J, Schubert C, Mangravite LM, Rudel LL, Temel RE, Runz H, Krauss RM. PMID: 25035345.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    21. HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism. Hum Mol Genet. 2014 Jan 15; 23(2):319-32. Yu CY, Theusch E, Lo K, Mangravite LM, Naidoo D, Kutilova M, Medina MW. PMID: 24001602.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    22. RHOA is a modulator of the cholesterol-lowering effects of statin. PLoS Genet. 2012; 8(11):e1003058. Medina MW, Theusch E, Naidoo D, Bauzon F, Stevens K, Mangravite LM, Kuang YL, Krauss RM. PMID: 23166513.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    23. Absolute pitch twin study and segregation analysis. Twin Res Hum Genet. 2011 Apr; 14(2):173-8. Theusch E, Gitschier J. PMID: 21425900.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    24. Genome-wide study of families with absolute pitch reveals linkage to 8q24.21 and locus heterogeneity. Am J Hum Genet. 2009 Jul; 85(1):112-9. Theusch E, Basu A, Gitschier J. PMID: 19576568.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    25. Separate pathways of RNA recruitment lead to the compartmentalization of the zebrafish germ plasm. Dev Biol. 2006 Apr 01; 292(1):129-41. Theusch EV, Brown KJ, Pelegri F. PMID: 16457796.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    26. Transplantation of neural progenitor cells into the developing retina of the Brazilian opossum: an in vivo system for studying stem/progenitor cell plasticity. Dev Neurosci. 2004; 26(5-6):336-45. Sakaguchi DS, Van Hoffelen SJ, Theusch E, Parker E, Orasky J, Harper MM, Benediktsson A, Young MJ. PMID: 15855762.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
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