Emily Goldberg, PhD

Title(s)Assistant Professor, Physiology
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-3848-6590 Additional info
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    Collapse Overview 
    Collapse Overview
    Persistent low-grade inflammation during aging underlies many chronic diseases, including insulin resistance, cardiovascular diseases, Alzheimer’s disease, and immunesenescence. Development of effective strategies to dampen age-related inflammation have been limited by our lack of understanding of the basic mechanisms that lead to its accumulation. We use integrative approaches to understand how immune-metabolic interactions regulate inflammation and can be harnessed to improve immunity and health during aging.

    Collapse Research 
    Collapse Research Activities and Funding
    Impact of ketone bodies on age-related inflammation and healthspan extension
    NIH R00AG058801Jan 1, 2019 - May 31, 2023
    Role: Principal Investigator
    Impact of ketone bodies on age-related inflammation and healthspan extension
    NIH K99AG058801Jan 1, 2019 - Dec 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Non-specific recognition of histone modifications by H3K9bhb antibody. bioRxiv. 2023 Apr 13. Tsusaka T, Oses-Prieto JA, Lee C, DeFelice BC, Burlingame AL, Goldberg E. PMID: 37090555; PMCID: PMC10120668.
      View in: PubMed   Mentions:
    2. Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation. J Biol Chem. 2023 03; 299(3):103005. Goldberg EL, Letian A, Dlugos T, Leveau C, Dixit VD. PMID: 36775129; PMCID: PMC10025153.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis. Proc Natl Acad Sci U S A. 2021 11 23; 118(47). Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C. PMID: 34782454; PMCID: PMC8617522.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    4. IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2. Cell Metab. 2021 11 02; 33(11):2277-2287.e5. Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD. PMID: 34473956; PMCID: PMC9067336.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    5. Integration of immune-metabolic signals to preserve healthy aging. Transl Med Aging. 2020; 4:93-95. Goldberg EL. PMID: 33644501; PMCID: PMC7906256.
      View in: PubMed   Mentions:
    6. Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. Med (N Y). 2020 12 18; 1(1):43-65. Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC. PMID: 32838361; PMCID: PMC7362813.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCellsPHPublic Health
    7. How Inflammation Blunts Innate Immunity in Aging. Interdiscip Top Gerontol Geriatr. 2020; 43:1-17. Goldberg EL, Shaw AC, Montgomery RR. PMID: 32294641; PMCID: PMC8063508.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    8. Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue. Nat Metab. 2020 01; 2(1):50-61. Goldberg EL, Shchukina I, Asher JL, Sidorov S, Artyomov MN, Dixit VD. PMID: 32694683.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    9. Ketogenic diet activates protective γδ T cell responses against influenza virus infection. Sci Immunol. 2019 11 15; 4(41). Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A. PMID: 31732517; PMCID: PMC7189564.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    10. Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metab. 2019 12 03; 30(6):1024-1039.e6. Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD. PMID: 31735593; PMCID: PMC6944439.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    11. Bone Marrow: An Immunometabolic Refuge during Energy Depletion. Cell Metab. 2019 10 01; 30(4):621-623. Goldberg EL, Dixit VD. PMID: 31577929.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    12. Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance. J Physiol. 2019 08; 597(15):3885-3903. Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI. PMID: 31206703; PMCID: PMC6876753.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    13. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature. 2017 10 05; 550(7674):119-123. Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD. PMID: 28953873; PMCID: PMC5718149.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    14. β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. Cell Rep. 2017 02 28; 18(9):2077-2087. Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD. PMID: 28249154; PMCID: PMC5527297.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    15. Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation. Mol Metab. 2017 02; 6(2):219-225. Goldberg EL, Dixit VD. PMID: 28180063; PMCID: PMC5279934.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence. Cell Rep. 2016 Feb 23; 14(7):1571-1580. Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD. PMID: 26876170; PMCID: PMC5992590.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    17. Editorial: "Crowning" eosinophils in adipose tissue: does location matter? J Leukoc Biol. 2015 Oct; 98(4):451-2. Goldberg EL, Dixit VD. PMID: 26429777.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. Regulation of Nlrp3 inflammasome by dietary metabolites. Semin Immunol. 2015 Sep; 27(5):334-42. Camell C, Goldberg E, Dixit VD. PMID: 26776831; PMCID: PMC4821737.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    19. Drivers of age-related inflammation and strategies for healthspan extension. Immunol Rev. 2015 May; 265(1):63-74. Goldberg EL, Dixit VD. PMID: 25879284; PMCID: PMC4400872.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    20. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015 Mar; 21(3):263-9. Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. PMID: 25686106; PMCID: PMC4352123.
      View in: PubMed   Mentions: 645     Fields:    Translation:HumansAnimalsCells
    21. Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms. Aging Cell. 2015 Feb; 14(1):130-8. Goldberg EL, Romero-Aleshire MJ, Renkema KR, Ventevogel MS, Chew WM, Uhrlaub JL, Smithey MJ, Limesand KH, Sempowski GD, Brooks HL, Nikolich-Žugich J. PMID: 25424641; PMCID: PMC4326902.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    22. Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections. J Immunol. 2014 Jul 15; 193(2):757-63. Goldberg EL, Smithey MJ, Lutes LK, Uhrlaub JL, Nikolich-Žugich J. PMID: 24913978; PMCID: PMC4119820.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    23. Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses. PLoS Pathog. 2013 Sep; 9(9):e1003572. Rudd BD, Venturi V, Smith NL, Nzingha K, Goldberg EL, Li G, Nikolich-Zugich J, Davenport MP. PMID: 24068921; PMCID: PMC3771883.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    24. Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice. Age (Dordr). 2014 Feb; 36(1):199-212. Kusne Y, Goldberg EL, Parker SS, Hapak SM, Maskaykina IY, Chew WM, Limesand KH, Brooks HL, Price TJ, Sanai N, Nikolich-Zugich J, Ghosh S. PMID: 23949159; PMCID: PMC3889877.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
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