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Emily Goldberg, PhD

Title(s)Assistant Professor, Physiology
SchoolSchool of Medicine
Phone415-502-3932
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    Persistent low-grade inflammation during aging underlies many chronic diseases, including insulin resistance, cardiovascular diseases, Alzheimer’s disease, and immunesenescence. Development of effective strategies to dampen age-related inflammation have been limited by our lack of understanding of the basic mechanisms that lead to its accumulation. We use integrative approaches to understand how immune-metabolic interactions regulate inflammation and can be harnessed to improve immunity and health during aging.

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    Impact of ketone bodies on age-related inflammation and healthspan extension
    NIH/NIA K99AG058801Jan 1, 2019 - Dec 31, 2020
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. Med (N Y). 2020 Jul 15. Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC. PMID: 32838361.
      View in: PubMed   Mentions:
    2. How Inflammation Blunts Innate Immunity in Aging. Interdiscip Top Gerontol Geriatr. 2020; 43:1-17. Goldberg EL, Shaw AC, Montgomery RR. PMID: 32294641.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    3. Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue. Nat Metab. 2020 Jan; 2(1):50-61. Goldberg EL, Shchukina I, Asher JL, Sidorov S, Artyomov MN, Dixit VD. PMID: 32694683.
      View in: PubMed   Mentions:
    4. Ketogenic diet activates protective γδ T cell responses against influenza virus infection. Sci Immunol. 2019 11 15; 4(41). Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A. PMID: 31732517.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    5. Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metab. 2019 12 03; 30(6):1024-1039.e6. Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD. PMID: 31735593.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    6. Bone Marrow: An Immunometabolic Refuge during Energy Depletion. Cell Metab. 2019 10 01; 30(4):621-623. Goldberg EL, Dixit VD. PMID: 31577929.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    7. Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance. J Physiol. 2019 08; 597(15):3885-3903. Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI. PMID: 31206703.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature. 2017 10 05; 550(7674):119-123. Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD. PMID: 28953873.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    9. ß-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. Cell Rep. 2017 02 28; 18(9):2077-2087. Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD. PMID: 28249154.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    10. Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation. Mol Metab. 2017 02; 6(2):219-225. Goldberg EL, Dixit VD. PMID: 28180063.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence. Cell Rep. 2016 Feb 23; 14(7):1571-1580. Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD. PMID: 26876170.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    12. Editorial: "Crowning" eosinophils in adipose tissue: does location matter? J Leukoc Biol. 2015 Oct; 98(4):451-2. Goldberg EL, Dixit VD. PMID: 26429777.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. Regulation of Nlrp3 inflammasome by dietary metabolites. Semin Immunol. 2015 Sep; 27(5):334-42. Camell C, Goldberg E, Dixit VD. PMID: 26776831.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    14. Drivers of age-related inflammation and strategies for healthspan extension. Immunol Rev. 2015 May; 265(1):63-74. Goldberg EL, Dixit VD. PMID: 25879284.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    15. The ketone metabolite ß-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015 Mar; 21(3):263-9. Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. PMID: 25686106.
      View in: PubMed   Mentions: 264     Fields:    Translation:HumansAnimalsCells
    16. Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms. Aging Cell. 2015 Feb; 14(1):130-8. Goldberg EL, Romero-Aleshire MJ, Renkema KR, Ventevogel MS, Chew WM, Uhrlaub JL, Smithey MJ, Limesand KH, Sempowski GD, Brooks HL, Nikolich-Žugich J. PMID: 25424641.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    17. Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections. J Immunol. 2014 Jul 15; 193(2):757-63. Goldberg EL, Smithey MJ, Lutes LK, Uhrlaub JL, Nikolich-Žugich J. PMID: 24913978.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    18. Acute neonatal infections 'lock-in' a suboptimal CD8+ T cell repertoire with impaired recall responses. PLoS Pathog. 2013 Sep; 9(9):e1003572. Rudd BD, Venturi V, Smith NL, Nzingha K, Goldberg EL, Li G, Nikolich-Zugich J, Davenport MP. PMID: 24068921.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    19. Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice. Age (Dordr). 2014 Feb; 36(1):199-212. Kusne Y, Goldberg EL, Parker SS, Hapak SM, Maskaykina IY, Chew WM, Limesand KH, Brooks HL, Price TJ, Sanai N, Nikolich-Zugich J, Ghosh S. PMID: 23949159.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
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