Neel Singhal, MD, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
PronounsHe/Him/His
ORCID ORCID Icon0000-0003-1605-4444 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Bard College at Simon's RockA.A.1999
    Rice UniversityB.A.2001Cognitive Science
    University of PennsylvaniaM.D./Ph.D.2009Neuroscience
    UCSFResidency2013Neurology
    UCSFFellowship2015Neurocritical Care
    University of California, San Francisco, CA2019Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    I am a neurologist trained in neurocritical care. I attend in the neurocritical care unit at Zuckerberg San Francisco General Hospital and UCSF. I perform basic laboratory and translational research to improve our ability to diagnose, treat, and prognosticate in patients with stroke and other critical neurologic injuries. My discovery research program aims to identify new pathways for neuroprotection and neuro-resilience by focusing on targets identified in human genome-wide association studies and on models of ischemia tolerance including the uniquely resilient Arctic ground squirrel. My pre-clinical translational program is focused on the use of multi-omic biomarkers to gain clues about new treatments for brain injury and neuro-recovery. My collaborative research in neurodegenerative disease brings together our laboratories expertise in mouse models with state-of-the-art CRISPR-based treatments (Clelland and Ma Labs) to work towards a cure for genetic neurological diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting PATJ to improve neurorecovery following ischemic stroke
    UCSF RAP REACJul 1, 2023 - Jun 30, 2024
    Resilience mechanisms of Arctic ground squirrel neurons
    Veterans Affairs Office of Sponsored Research Jan 1, 2022 - Dec 31, 2026
    Role: Principal Investigator
    Modeling neuronal resilience with stroke genetic variants in human iPSCs
    Hellman Family Fund Jul 1, 2020 - Jun 30, 2022
    Role: Principal Investigator
    Elucidating the role of respirasome plasticity in neuronal metabolism and resilience to ischemic injury
    American Heart Association 18CDA34030443Jul 1, 2018 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium. Medrxiv. 2025. Sara C. LaHue, Naoki Takegami, Rubinee Simmasalam, Abiya Baqai, Elena Munoz, Anya Sikri, Thibault du Buisson de Courson, Nilika S. Singhal, Walter Eckalbar, Charles R. Langelier, Carolyn M. Hendrickson, Carolyn S. Calfee, David J. Erle, Matthew F. Krummel, Prescott G. Woodruff, Tomiko Oskotsky, Marina Sirota, Adam Ferguson, Vanja C. Douglas, John C. Newman, Samuel J. Pleasure, Michael R. Wilson, COMET consortium, Neel S. Singhal. . View Publication.
    2. Abstract DP14: Neuroinflammatory mechanisms linking metabolic syndrome with vascular cognitive impairment. Stroke. 2025 Feb 1; 56(Suppl_1):adp14-adp14. Zhang ZM, Letian LA, Goldberg GE, Arkelius AK, SINGHAL SN. .
      View in: Publisher Site   Mentions:
    3. Abstract TP380: TMEM97 and Lipid Metabolism: Unraveling Post-Stroke Lipid Regulation. Stroke. 2025 Feb 1; 56(Suppl_1):atp380-atp380. Arkelius AK, Won WS, Gupta GL, Zhang ZM, Swanson SR, SINGHAL SN. .
      View in: Publisher Site   Mentions:
    4. Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis. Proc Natl Acad Sci U S A. 2025 Feb 04; 122(5):e2417515122. Jiang WI, Cao Y, Xue Y, Ji Y, Winer BY, Chandra R, Zhang XF, Zhang M, Singhal NS, Pierce JT, Chen S, Ma DK. PMID: 39874294; PMCID: PMC11804744.
      View in: PubMed   Mentions:    Fields:    
    5. Small RNA signatures of acute ischemic stroke in L1CAM positive extracellular vesicles. Sci Rep. 2024 06 12; 14(1):13560. Manwani B, Brathaban N, Baqai A, Munshi Y, Ahnstedt HW, Zhang M, Arkelius K, Llera T, Amorim E, Elahi FM, Singhal NS. PMID: 38866905; PMCID: PMC11169361.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. PATJ regulates cell stress responses and vascular remodeling post-stroke. Biorxiv. 2024. Zhang M, Jiang W, Arkelius, KA, Swanson RA, Ma DK, Singhal NS. View Publication.
    7. Neuroprotectants. Ischemic Stroke Therapeutics. 2024 Apr 24; 11-32. Singhal SN, Swanson SR, Yenari YM. .
      View in: Publisher Site   Mentions:
    8. ATF3 is a neuron-specific biomarker for spinal cord injury and ischaemic stroke. Clin Transl Med. 2024 Apr; 14(4):e1650. Pan JZ, Wang Z, Sun W, Pan P, Li W, Sun Y, Chen S, Lin A, Tan W, He L, Greene J, Yao V, An L, Liang R, Li Q, Yu J, Zhang L, Kyritsis N, Fernandez XD, Moncivais S, Mendoza E, Fung P, Wang G, Niu X, Du Q, Xiao Z, Chang Y, Lv P, Huie JR, Torres-Espin A, Ferguson AR, Hemmerle DD, Talbott JF, Weinstein PR, Pascual LU, Singh V, DiGiorgio AM, Saigal R, Whetstone WD, Manley GT, Dhall SS, Bresnahan JC, Maze M, Jiang X, Singhal NS, Beattie MS, Su H, Guan Z. PMID: 38649772; PMCID: PMC11035380.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Management of Status Epilepticus and Indications for Inpatient Electroencephalography Monitoring. Neurol Clin. 2022 02; 40(1):1-16. Fan JM, Singhal NS, Guterman EL. PMID: 34798964.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Abstract TP251: CRISPR-engineered Mouse Neural Cells Expressing An Optimized Manf Variant Reveals Mechanisms Of MANF Neuroprotection. Stroke. 2022 Feb 1; 53(Suppl_1):atp251-atp251. Llera LT, Singhal SN, Ma MD. .
      View in: Publisher Site   Mentions:
    11. Diabetes, stroke, and neuroresilience: looking beyond hyperglycemia. Ann N Y Acad Sci. 2021 07; 1495(1):78-98. Krinock MJ, Singhal NS. PMID: 33638222.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    12. Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells. Elife. 2020 10 14; 9. Singhal NS, Bai M, Lee EM, Luo S, Cook KR, Ma DK. PMID: 33050999; PMCID: PMC7671683.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    13. Resilience to Injury: A New Approach to Neuroprotection? Neurotherapeutics. 2020 04; 17(2):457-474. Singhal NS, Sun CH, Lee EM, Ma DK. PMID: 31997268; PMCID: PMC7283435.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    14. Neuronal GDPGP1 and glycogen metabolism: friend or foe? J Cell Biol. 2020 02 03; 219(2). Singhal NS, Lee EM, Ma DK. PMID: 31971543; PMCID: PMC7041681.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    15. Abstract TP110: Dissecting the Optimized Cytoprotective Responses of Arctic Ground Squirrels With CRISPR. Stroke. 2020 Feb 1; 51(Suppl_1). Lee LE, Singhal SN, Bai BM, Ma MD. .
      View in: Publisher Site   Mentions:
    16. Endovascular Treatment of Stroke, Oral Anticoagulant-associated Intracerebral Hemorrhage, and Treatment of Extracranial Dissection. Am J Respir Crit Care Med. 2016 01 15; 193(2):210-2. Thabet AM, Kottapally M, Singhal NS. PMID: 26583686.
      View in: PubMed   Mentions:    Fields:    
    17. Diagnosing Balamuthia mandrillaris Encephalitis With Metagenomic Deep Sequencing. Ann Neurol. 2015 Nov; 78(5):722-30. Wilson MR, Shanbhag NM, Reid MJ, Singhal NS, Gelfand JM, Sample HA, Benkli B, O'Donovan BD, Ali IK, Keating MK, Dunnebacke TH, Wood MD, Bollen A, DeRisi JL. PMID: 26290222; PMCID: PMC4624031.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimals
    18. Sarcoid polyneuropathy masquerading as chronic inflammatory demyelinating polyneuropathy. Muscle Nerve. 2015 Oct; 52(4):664-8. Singhal NS, Irodenko VS, Margeta M, Layzer RB. PMID: 25786655.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Immediate Hemorrhagic Transformation After Intravenous Tissue-Type Plasminogen Activator Injection in 2 Cocaine Users. Stroke. 2015 Jul; 46(7):e167-9. Baud MO, Brown EG, Singhal NS, Hemphill JC. PMID: 25922508.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. Balamuthia mandrillaris Meningoencephalitis and Central Nervous System Vasculitis Diagnosed by Next-Generation Sequencing of Cerebrospinal Fluid (S37.008). Neurology. 2015 Apr 6; 84(14_supplement). Shanbhag SN, Wilson WM, Reid RM, Singhal SN, Benkli BB, Gelfand GJ, Sample SH, Wood WM, Bollen BA, DeRisi DJ. .
      View in: Publisher Site   Mentions:
    21. Effect of rituximab in patients with leucine-rich, glioma-inactivated 1 antibody-associated encephalopathy. JAMA Neurol. 2014 Jul 01; 71(7):896-900. Irani SR, Gelfand JM, Bettcher BM, Singhal NS, Geschwind MD. PMID: 24842754; PMCID: PMC4477824.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    22. A practical approach to neurologic evaluation in the intensive care unit. J Crit Care. 2014 Aug; 29(4):627-33. Singhal NS, Josephson SA. PMID: 24636925.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. Unconscious processing of color and form in metacontrast masking. Atten Percept Psychophys. 2009 Jan; 71(1):95-103. Ro T, Singhal NS, Breitmeyer BG, Garcia JO. PMID: 19304600.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    24. Inhibition of ADRP prevents diet-induced insulin resistance. Am J Physiol Gastrointest Liver Physiol. 2008 Sep; 295(3):G621-8. Varela GM, Antwi DA, Dhir R, Yin X, Singhal NS, Graham MJ, Crooke RM, Ahima RS. PMID: 18669627; PMCID: PMC2536783.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    25. Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice. Am J Physiol Endocrinol Metab. 2008 Aug; 295(2):E331-8. Singhal NS, Patel RT, Qi Y, Lee YS, Ahima RS. PMID: 18505833; PMCID: PMC2519749.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    26. Hypothalamic control of energy homeostasis. Neurobiology of Obesity. 2008 Jan 1; 52-82. Singhal SN, Ahima AR. .
      View in: Publisher Site   Mentions:
    27. Central resistin induces hepatic insulin resistance via neuropeptide Y. J Neurosci. 2007 Nov 21; 27(47):12924-32. Singhal NS, Lazar MA, Ahima RS. PMID: 18032666; PMCID: PMC6673286.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    28. Brain adipocytokine action and metabolic regulation. Diabetes. 2006 Dec; 55 Suppl 2:S145-54. Ahima RS, Qi Y, Singhal NS, Jackson MB, Scherer PE. PMID: 17130638.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    29. Loss of resistin improves glucose homeostasis in leptin deficiency. Diabetes. 2006 Nov; 55(11):3083-90. Qi Y, Nie Z, Lee YS, Singhal NS, Scherer PE, Lazar MA, Ahima RS. PMID: 17065346.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    30. Adipokines that link obesity and diabetes to the hypothalamus. Prog Brain Res. 2006; 153:155-74. Ahima RS, Qi Y, Singhal NS. PMID: 16876574.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    31. Unconscious color priming occurs at stimulus- not percept-dependent levels of processing. Psychol Sci. 2004 Mar; 15(3):198-202. Breitmeyer BG, Ro T, Singhal NS. PMID: 15016292.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    32. Feedback contributions to visual awareness in human occipital cortex. Curr Biol. 2003 Jun 17; 13(12):1038-41. Ro T, Breitmeyer B, Burton P, Singhal NS, Lane D. PMID: 12814549.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    33. Effects of lithium chloride on induction and expression of methylphenidate sensitization. Eur J Pharmacol. 2001 Aug 24; 426(1-2):65-72. Yang P, Singhal N, Modi G, Swann A, Dafny N. PMID: 11525772.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
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