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John Newman, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address490 Illinois Street
San Francisco CA 94158
Phone415-502-5134
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    Collapse Biography 
    Collapse Education and Training
    Yale UniversityBS/MS2000Molecular Biophysics and Biochemistry
    University of WashingtonMD/PhD2008Biochemistry
    UCSFResidency2010Internal Medicine
    UCSFFellowship2011Geriatric Medicine
    Collapse Awards and Honors
    National Institute on Aging and American Federation for Aging Research2014  - 2019Beeson Scholar
    American Geriatrics Society2018Outstanding Junior Investigator of the Year
    Larry L. Hillblom Foundation2012  - 2015Postdoctoral Fellowship
    American Geriatrics Society2015New Investigator Award
    Larry L. Hillblom Foundation2014John S. Spice Award in Aging
    Paul F. Glenn Foundation2013Glenn Award for Research in Biological Mechanisms of Aging
    Gladstone Institute of Virology and Immunology2013Award of Excellence in Scientific Leadership
    John A. Hartford Foundation2011  - 2013Hartford Scholar

    Collapse Overview 
    Collapse Overview
    Dr. Newman is a geriatrician, basic science researcher, and educator at the Buck Institute for Research on Aging and in the Division of Geriatrics at UCSF. As a physician-scientist, Dr. Newman hopes to translate what we are learning of the pathways that control fundamental mechanisms of aging into therapies that will improve the health and preserve the independence of older adults.

    His research work as an Assistant Professor at the Buck Institute, in sunny Novato, focuses on how ketone bodies, small molecules that our bodies make for energy when we fast or exercise, also act as molecular signals to control inflammation and gene expression. The signaling functions of ketone bodies may be translational targets for protecting cognition and improving resilience in older adults. This is one example how environmental cues like diet and fasting signal through small metabolites in our cells to regulate the genes and pathways that in turn control aging. Dr. Newman is particularly interested in testing if harnessing these signals can protect older adults from the risks of hospitalization like delirium and functional decline.

    Dr. Newman attends on the inpatient medicine service and the acute care of elders unit at the San Francisco VA Medical Center, with a clinical focus on delirium and functional decline. He teaches students, residents, and fellows about geriatric clinical problems, as well as about the biology of aging and emerging translational science in geriatrics. He works as a part of the national Geroscience Network to develop frameworks and resources for testing interventions that target fundamental mechanisms of aging in clinical trials. He seeks to bridge the community of basic scientists that study aging to geriatricians and other clinicians who study the clinical problems of aging in order to develop innovative translational therapies.

    Dr. Newman completed an MD/PhD at the University of Washington in Seattle, then residency training in Internal Medicine and a fellowship in Geriatrics at UCSF before joining the faculty in 2014. He joined the faculty of the Buck Institute in 2018. Dr. Newman is a 2014 Beeson Scholar from the National Institute on Aging and the American Federation of Aging Research. His work has also been supported by generous funding from the Larry L. Hillblom Foundation and the Glenn Foundation for Medical Research.

    Assistant Professor, Buck Institute for Research on Aging
    Assistant Professor, Division of Geriatrics at UCSF
    Geriatrician, San Francisco VA Medical Center

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of the signaling metabolite ?-hydroxybutyrate in Alzheimer's disease and the aging brain
    NIH/NIA R01AG067333Jun 1, 2020 - May 31, 2025
    Role: Principal Investigator
    Epigenetic regulation of healthspan and longevity by ketone bodies
    NIH/NIA K08AG048354Sep 1, 2014 - May 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience. Geroscience. 2020 Oct 02. Stubbs BJ, Koutnik AP, Volek JS, Newman JC. PMID: 33006708.
      View in: PubMed   Mentions:    Fields:    
    2. Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. Med (N Y). 2020 Jul 15. Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC. PMID: 32838361.
      View in: PubMed   Mentions:
    3. Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells. Cell. 2020 Jun 11; 181(6):1263-1275.e16. Ang QY, Alexander M, Newman JC, Tian Y, Cai J, Upadhyay V, Turnbaugh JA, Verdin E, Hall KD, Leibel RL, Ravussin E, Rosenbaum M, Patterson AD, Turnbaugh PJ. PMID: 32437658.
      View in: PubMed   Mentions: 7     Fields:    
    4. Collaborative Delirium Prevention in the Age of COVID-19. J Am Geriatr Soc. 2020 05; 68(5):947-949. LaHue SC, James TC, Newman JC, Esmaili AM, Ormseth CH, Ely EW. PMID: 32277467.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic Health
    5. Ketogenic diet and adipose tissue inflammation-a simple story? Fat chance! Nat Metab. 2020 Jan; 2(1):3-4. Stubbs BJ, Newman JC. PMID: 32694682.
      View in: PubMed   Mentions:
    6. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019 07; 571(7764):183-192. Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. PMID: 31292558.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    7. Creating the Next Generation of Translational Geroscientists. J Am Geriatr Soc. 2019 09; 67(9):1934-1939. Newman JC, Sokoloski JL, Robbins PD, Niedernhofer LJ, Reed MJ, Wei J, Austad SN, Barzilai N, Cohen HJ, Kuchel GA, Kirkland JL, Pignolo RJ. PMID: 31287934.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series. J Am Geriatr Soc. 2019 03; 67(3):428-433. Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, Kirkland JL, Yung R. PMID: 30693953.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet. Cell Metab. 2017 Sep 05; 26(3):523-538.e5. Tognini P, Murakami M, Liu Y, Eckel-Mahan KL, Newman JC, Verdin E, Baldi P, Sassone-Corsi P. PMID: 28877456.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    10. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. Cell Metab. 2017 Sep 05; 26(3):547-557.e8. Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E. PMID: 28877458.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    11. ß-Hydroxybutyrate: A Signaling Metabolite. Annu Rev Nutr. 2017 08 21; 37:51-76. Newman JC, Verdin E. PMID: 28826372.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    12. Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes. J Gerontol A Biol Sci Med Sci. 2016 11; 71(11):1415-1423. Justice J, Miller JD, Newman JC, Hashmi SK, Halter J, Austad SN, Barzilai N, Kirkland JL. PMID: 27535966.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    13. Strategies and Challenges in Clinical Trials Targeting Human Aging. J Gerontol A Biol Sci Med Sci. 2016 11; 71(11):1424-1434. Newman JC, Milman S, Hashmi SK, Austad SN, Kirkland JL, Halter JB, Barzilai N. PMID: 27535968.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    14. Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife. 2016 05 31; 5. Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E. PMID: 27244239.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    15. Dextromethorphan-Quinidine for Agitation in Alzheimer Disease. JAMA. 2016 Mar 15; 315(11):1166. Newman JC, Steinman MA. PMID: 26978214.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Copyright and Bedside Cognitive Testing: Why We Need Alternatives to the Mini-Mental State Examination. JAMA Intern Med. 2015 Sep; 175(9):1459-60. Newman JC. PMID: 26053392.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansPHPublic Health
    17. ß-hydroxybutyrate: much more than a metabolite. Diabetes Res Clin Pract. 2014 Nov; 106(2):173-81. Newman JC, Verdin E. PMID: 25193333.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    18. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 2013 Dec 03; 18(6):920-33. Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E. PMID: 24315375.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansAnimalsCells
    19. Ketone bodies as signaling metabolites. Trends Endocrinol Metab. 2014 Jan; 25(1):42-52. Newman JC, Verdin E. PMID: 24140022.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    20. Long-term outcomes in elderly survivors of cardiac arrest. N Engl J Med. 2013 06 20; 368(25):2438. Yee P, Newman J. PMID: 23782194.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6601-6. Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. PMID: 23576753.
      View in: PubMed   Mentions: 143     Fields:    Translation:AnimalsCells
    22. Copyright at the Bedside: Should We Stop the Spread?. Stanford Technology Law Review. 2013; 16(3):623. Feldman R, Newman J.. View Publication.
    23. Suppression of oxidative stress by ß-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013 Jan 11; 339(6116):211-4. Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E. PMID: 23223453.
      View in: PubMed   Mentions: 321     Fields:    Translation:HumansAnimalsCells
    24. Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem. 2012 Dec 14; 287(51):42436-43. Newman JC, He W, Verdin E. PMID: 23086951.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    25. Mitochondrial sirtuins: regulators of protein acylation and metabolism. Trends Endocrinol Metab. 2012 Sep; 23(9):467-76. He W, Newman JC, Wang MZ, Ho L, Verdin E. PMID: 22902903.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    26. The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells. DNA Repair (Amst). 2012 May 01; 11(5):488-501. Bailey AD, Gray LT, Pavelitz T, Newman JC, Horibata K, Tanaka K, Weiner AM. PMID: 22483866.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    27. Copyright and open access at the bedside. N Engl J Med. 2011 Dec 29; 365(26):2447-9. Newman JC, Feldman R. PMID: 22204721.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    28. Leriche syndrome. J Gen Intern Med. 2010 Oct; 25(10):1102-4. Frederick M, Newman J, Kohlwes J. PMID: 20568019.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    29. An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome. PLoS Genet. 2008 Mar 21; 4(3):e1000031. Newman JC, Bailey AD, Fan HY, Pavelitz T, Weiner AM. PMID: 18369450.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    30. Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardization. Gene. 2007 Oct 15; 401(1-2):12-8. Cahan P, Rovegno F, Mooney D, Newman JC, St Laurent G, McCaffrey TA. PMID: 17651921.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimals
    31. Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling. Proc Natl Acad Sci U S A. 2006 Jun 20; 103(25):9613-8. Newman JC, Bailey AD, Weiner AM. PMID: 16772382.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    32. L2L: a simple tool for discovering the hidden significance in microarray expression data. Genome Biol. 2005; 6(9):R81. Newman JC, Weiner AM. PMID: 16168088.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimals
    33. Measuring the immeasurable. Mol Cell. 2002 Sep; 10(3):437-9. Newman JC, Weiner A. PMID: 12408812.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    34. The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction. Mol Cell Biol. 2001 Dec; 21(23):8104-16. Schutzman JL, Borland CZ, Newman JC, Robinson MK, Kokel M, Stern MJ. PMID: 11689700.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
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