John Newman, MD, PhD
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Title(s) | Assistant Professor, Medicine |
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School | School of Medicine |
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Address | Location Required Varies CA 00000
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Phone | 415-502-5134 |
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vCard | Download vCard |
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Biography Yale University | BS/MS | 2000 | Molecular Biophysics and Biochemistry | University of Washington | MD/PhD | 2008 | Biochemistry | UCSF | Residency | 2010 | Internal Medicine | UCSF | Fellowship | 2011 | Geriatric Medicine |
National Institute on Aging and American Federation for Aging Research | 2014
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| 2019 | Beeson Scholar | American Geriatrics Society | 2018 | | Outstanding Junior Investigator of the Year | Larry L. Hillblom Foundation | 2012
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| 2015 | Postdoctoral Fellowship | American Geriatrics Society | 2015 | | New Investigator Award | Larry L. Hillblom Foundation | 2014 | | John S. Spice Award in Aging | Paul F. Glenn Foundation | 2013 | | Glenn Award for Research in Biological Mechanisms of Aging | Gladstone Institute of Virology and Immunology | 2013 | | Award of Excellence in Scientific Leadership | John A. Hartford Foundation | 2011
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| 2013 | Hartford Scholar |
Overview Dr. Newman is a geriatrician, basic science researcher, and educator at the Buck Institute for Research on Aging and in the Division of Geriatrics at UCSF. As a physician-scientist, Dr. Newman hopes to translate what we are learning of the pathways that control fundamental mechanisms of aging into therapies that will improve the health and preserve the independence of older adults.
His research work as an Assistant Professor at the Buck Institute, in sunny Novato, focuses on how ketone bodies, small molecules that our bodies make for energy when we fast or exercise, also act as molecular signals to control inflammation and gene expression. The signaling functions of ketone bodies may be translational targets for protecting cognition and improving resilience in older adults. This is one example how environmental cues like diet and fasting signal through small metabolites in our cells to regulate the genes and pathways that in turn control aging. Dr. Newman is particularly interested in testing if harnessing these signals can protect older adults from the risks of hospitalization like delirium and functional decline.
Dr. Newman attends on the inpatient medicine service and the acute care of elders unit at the San Francisco VA Medical Center, with a clinical focus on delirium and functional decline. He teaches students, residents, and fellows about geriatric clinical problems, as well as about the biology of aging and emerging translational science in geriatrics. He works as a part of the national Geroscience Network to develop frameworks and resources for testing interventions that target fundamental mechanisms of aging in clinical trials. He seeks to bridge the community of basic scientists that study aging to geriatricians and other clinicians who study the clinical problems of aging in order to develop innovative translational therapies.
Dr. Newman completed an MD/PhD at the University of Washington in Seattle, then residency training in Internal Medicine and a fellowship in Geriatrics at UCSF before joining the faculty in 2014. He joined the faculty of the Buck Institute in 2018. Dr. Newman is a 2014 Beeson Scholar from the National Institute on Aging and the American Federation of Aging Research. His work has also been supported by generous funding from the Larry L. Hillblom Foundation and the Glenn Foundation for Medical Research.
Assistant Professor, Buck Institute for Research on Aging Assistant Professor, Division of Geriatrics at UCSF Geriatrician, San Francisco VA Medical Center
Research ORNG Applications Bibliographic
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Genetic Toxicity Studies of the Ketogenic Ester Bis Hexanoyl (R)-1,3-Butanediol. Int J Toxicol. 2021 Feb 22; 1091581821991772.
Stubbs BJ, Nikiforov AI, Rihner MO, Weston S, Higley N, Roy S, Dakoulas E, Verdin E, Newman JC. PMID: 33611970.
View in: PubMed Mentions: Fields:
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Toxicological Evaluation of the ketogenic ester Bis Hexanoyl (R)-1,3-Butanediol: Subchronic Toxicity in Sprague Dawley Rats. Food Chem Toxicol. 2021 Feb 20; 112084.
Stubbs BJ, Nikiforov AI, Rihner MO, Weston SL, Higley N, Stump DG, Krane GA, Gadupudi G, Verdin E, Newman JC. PMID: 33621607.
View in: PubMed Mentions: Fields:
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Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure. Circ Heart Fail. 2020 Dec 28; CIRCHEARTFAILURE120007684.
Yurista SR, Matsuura TR, Silljé HHW, Nijholt KT, McDaid KS, Shewale SV, Leone TC, Newman JC, Verdin E, van Veldhuisen DJ, de Boer RA, Kelly DP, Westenbrink BD. PMID: 33356362.
View in: PubMed Mentions: 1 Fields:
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SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. Nat Commun. 2020 11 23; 11(1):5927.
Gut P, Matilainen S, Meyer JG, Pällijeff P, Richard J, Carroll CJ, Euro L, Jackson CB, Isohanni P, Minassian BA, Alkhater RA, Østergaard E, Civiletto G, Parisi A, Thevenet J, Rardin MJ, He W, Nishida Y, Newman JC, Liu X, Christen S, Moco S, Locasale JW, Schilling B, Suomalainen A, Verdin E. PMID: 33230181.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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In vitro stability and in vivo pharmacokinetics of the novel ketogenic ester, bis hexanoyl (R)-1,3-butanediol. Food Chem Toxicol. 2020 Nov 17; 111859.
Stubbs BJ, Blade T, Mills S, Thomas J, Yufei X, Nelson FR, Higley N, Nikiforov AI, Rhiner MO, Verdin E, Newman JC. PMID: 33212214.
View in: PubMed Mentions: Fields:
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From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience. Geroscience. 2020 Oct 02.
Stubbs BJ, Koutnik AP, Volek JS, Newman JC. PMID: 33006708.
View in: PubMed Mentions: 1 Fields:
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Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. Med (N Y). 2020 Dec 18; 1(1):43-65.
Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC. PMID: 32838361.
View in: PubMed Mentions:
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Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells. Cell. 2020 06 11; 181(6):1263-1275.e16.
Ang QY, Alexander M, Newman JC, Tian Y, Cai J, Upadhyay V, Turnbaugh JA, Verdin E, Hall KD, Leibel RL, Ravussin E, Rosenbaum M, Patterson AD, Turnbaugh PJ. PMID: 32437658.
View in: PubMed Mentions: 9 Fields:
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Collaborative Delirium Prevention in the Age of COVID-19. J Am Geriatr Soc. 2020 05; 68(5):947-949.
LaHue SC, James TC, Newman JC, Esmaili AM, Ormseth CH, Ely EW. PMID: 32277467.
View in: PubMed Mentions: 7 Fields: Translation: HumansPHPublic Health
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Ketogenic diet and adipose tissue inflammation-a simple story? Fat chance! Nat Metab. 2020 01; 2(1):3-4.
Stubbs BJ, Newman JC. PMID: 32694682.
View in: PubMed Mentions:
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From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019 07; 571(7764):183-192.
Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. PMID: 31292558.
View in: PubMed Mentions: 47 Fields: Translation: HumansCells
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Creating the Next Generation of Translational Geroscientists. J Am Geriatr Soc. 2019 09; 67(9):1934-1939.
Newman JC, Sokoloski JL, Robbins PD, Niedernhofer LJ, Reed MJ, Wei J, Austad SN, Barzilai N, Cohen HJ, Kuchel GA, Kirkland JL, Pignolo RJ. PMID: 31287934.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series. J Am Geriatr Soc. 2019 03; 67(3):428-433.
Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, Kirkland JL, Yung R. PMID: 30693953.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet. Cell Metab. 2017 Sep 05; 26(3):523-538.e5.
Tognini P, Murakami M, Liu Y, Eckel-Mahan KL, Newman JC, Verdin E, Baldi P, Sassone-Corsi P. PMID: 28877456.
View in: PubMed Mentions: 22 Fields: Translation: AnimalsCells
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Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. Cell Metab. 2017 Sep 05; 26(3):547-557.e8.
Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E. PMID: 28877458.
View in: PubMed Mentions: 45 Fields: Translation: Animals
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ß-Hydroxybutyrate: A Signaling Metabolite. Annu Rev Nutr. 2017 08 21; 37:51-76.
Newman JC, Verdin E. PMID: 28826372.
View in: PubMed Mentions: 54 Fields: Translation: HumansAnimalsCells
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Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes. J Gerontol A Biol Sci Med Sci. 2016 11; 71(11):1415-1423.
Justice J, Miller JD, Newman JC, Hashmi SK, Halter J, Austad SN, Barzilai N, Kirkland JL. PMID: 27535966.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimals
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Strategies and Challenges in Clinical Trials Targeting Human Aging. J Gerontol A Biol Sci Med Sci. 2016 11; 71(11):1424-1434.
Newman JC, Milman S, Hashmi SK, Austad SN, Kirkland JL, Halter JB, Barzilai N. PMID: 27535968.
View in: PubMed Mentions: 40 Fields: Translation: HumansAnimals
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Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife. 2016 05 31; 5.
Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E. PMID: 27244239.
View in: PubMed Mentions: 18 Fields: Translation: HumansAnimalsCells
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Dextromethorphan-Quinidine for Agitation in Alzheimer Disease. JAMA. 2016 Mar 15; 315(11):1166.
Newman JC, Steinman MA. PMID: 26978214.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Copyright and Bedside Cognitive Testing: Why We Need Alternatives to the Mini-Mental State Examination. JAMA Intern Med. 2015 Sep; 175(9):1459-60.
Newman JC. PMID: 26053392.
View in: PubMed Mentions: 7 Fields: Translation: HumansPHPublic Health
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ß-hydroxybutyrate: much more than a metabolite. Diabetes Res Clin Pract. 2014 Nov; 106(2):173-81.
Newman JC, Verdin E. PMID: 25193333.
View in: PubMed Mentions: 57 Fields: Translation: HumansCells
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SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 2013 Dec 03; 18(6):920-33.
Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E. PMID: 24315375.
View in: PubMed Mentions: 163 Fields: Translation: HumansAnimalsCells
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Ketone bodies as signaling metabolites. Trends Endocrinol Metab. 2014 Jan; 25(1):42-52.
Newman JC, Verdin E. PMID: 24140022.
View in: PubMed Mentions: 164 Fields: Translation: HumansAnimalsCells
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Long-term outcomes in elderly survivors of cardiac arrest. N Engl J Med. 2013 06 20; 368(25):2438.
Yee P, Newman J. PMID: 23782194.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6601-6.
Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. PMID: 23576753.
View in: PubMed Mentions: 149 Fields: Translation: AnimalsCells
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Copyright at the Bedside: Should We Stop the Spread?. Stanford Technology Law Review. 2013; 16(3):623.
Feldman R, Newman J. . View Publication.
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Suppression of oxidative stress by ß-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013 Jan 11; 339(6116):211-4.
Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E. PMID: 23223453.
View in: PubMed Mentions: 353 Fields: Translation: HumansAnimalsCells
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Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem. 2012 Dec 14; 287(51):42436-43.
Newman JC, He W, Verdin E. PMID: 23086951.
View in: PubMed Mentions: 81 Fields: Translation: HumansCells
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Mitochondrial sirtuins: regulators of protein acylation and metabolism. Trends Endocrinol Metab. 2012 Sep; 23(9):467-76.
He W, Newman JC, Wang MZ, Ho L, Verdin E. PMID: 22902903.
View in: PubMed Mentions: 93 Fields: Translation: HumansAnimalsCells
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The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells. DNA Repair (Amst). 2012 May 01; 11(5):488-501.
Bailey AD, Gray LT, Pavelitz T, Newman JC, Horibata K, Tanaka K, Weiner AM. PMID: 22483866.
View in: PubMed Mentions: 13 Fields: Translation: HumansCells
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Copyright and open access at the bedside. N Engl J Med. 2011 Dec 29; 365(26):2447-9.
Newman JC, Feldman R. PMID: 22204721.
View in: PubMed Mentions: 20 Fields: Translation: Humans
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Leriche syndrome. J Gen Intern Med. 2010 Oct; 25(10):1102-4.
Frederick M, Newman J, Kohlwes J. PMID: 20568019.
View in: PubMed Mentions: 12 Fields: Translation: Humans
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An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome. PLoS Genet. 2008 Mar 21; 4(3):e1000031.
Newman JC, Bailey AD, Fan HY, Pavelitz T, Weiner AM. PMID: 18369450.
View in: PubMed Mentions: 35 Fields: Translation: HumansAnimalsCells
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Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardization. Gene. 2007 Oct 15; 401(1-2):12-8.
Cahan P, Rovegno F, Mooney D, Newman JC, St Laurent G, McCaffrey TA. PMID: 17651921.
View in: PubMed Mentions: 52 Fields: Translation: HumansAnimals
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Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling. Proc Natl Acad Sci U S A. 2006 Jun 20; 103(25):9613-8.
Newman JC, Bailey AD, Weiner AM. PMID: 16772382.
View in: PubMed Mentions: 64 Fields: Translation: HumansCells
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L2L: a simple tool for discovering the hidden significance in microarray expression data. Genome Biol. 2005; 6(9):R81.
Newman JC, Weiner AM. PMID: 16168088.
View in: PubMed Mentions: 62 Fields: Translation: HumansAnimals
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Measuring the immeasurable. Mol Cell. 2002 Sep; 10(3):437-9.
Newman JC, Weiner A. PMID: 12408812.
View in: PubMed Mentions: 2 Fields: Translation: Cells
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The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction. Mol Cell Biol. 2001 Dec; 21(23):8104-16.
Schutzman JL, Borland CZ, Newman JC, Robinson MK, Kokel M, Stern MJ. PMID: 11689700.
View in: PubMed Mentions: 19 Fields: Translation: AnimalsCells
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Year | Publications |
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2001 | 1 | 2002 | 1 | 2005 | 1 | 2006 | 1 | 2007 | 1 | 2008 | 1 | 2010 | 1 | 2011 | 1 | 2012 | 4 | 2013 | 5 | 2014 | 1 | 2015 | 1 | 2016 | 4 | 2017 | 3 | 2019 | 3 | 2020 | 8 | 2021 | 2 |
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