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Claire Clelland, MD, PhD

Photo of Claire Clelland, MD, PhD
Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address1651 4th Street, #421A
San Francisco CA 94158
ORCID ORCID Icon0000-0002-9112-2278 Additional info
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    Other Positions
    Title(s)John Douglas French Alzheimer's Foundation Founding Associates Endowed Professor

    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse education and training
    University of California, San Diego, San Diego, CAPh.D.08/2009Neuroscience
    University of Cambridge, Cambridge, UKM.Phil.07/2009Neuroscience
    University of California, Los Angeles, Los Angeles, CAM.D.05/2013Medicine
    University of California, San Francisco, San Francisco, CA06/2014Medicine Internship
    University of California, San Francisco, San Francisco, CA06/2017Neurology Residency
    University of California, San Francisco, CA2021Diversity, Equity, and Inclusion Champion Training
    Collapse awards and honors
    Gladstone Institues2022Outstanding Mentoring Award
    American Neurological Association (ANA)2024Grass Foundation Award in Neuroscience
    Alzheimer’s Association & NACC2024New Investigator Award
    Bakar Labs2023QB3 Defeating Dementia Prize
    Equalize (National Women Academic Entrepreneurs) 2023Therapeutics Prize
    UCSF2021School of Medicine Dean’s Commendation for Exceptional Volunteerism and Community Service for
    UCSF2021Weill Award for Clinician-Scientists in the Neurosciences
    Alzheimer’s Association 2017  - 2020Clinician Scientist Fellowship
    UCLA Department of Neurology2013Richard D. Walter Award for Excellence in Neurology
    UK Marshall Aid Commemoration Commission, British Parliament 2006  - 2008Marshall Scholarship
    Jack Kent Cooke Foundation2005  - 2013Jack Kent Cooke Graduate Fellowship

    Collapse Overview 
    Collapse overview
    Dr. Clelland, PhD, MD, MPhil, is an Assistant Professor in the UCSF Department of Neurology. As a neurologist, she specializes in caring for patients with dementia and cognitive symptoms at the UCSF Memory & Aging Center. Her lab at the UCSF Weill Institute for Neurosciences develops novel therapies for neurodegenerative diseases. Her current work centers on creating novel CRISPR gene therapies for genetic forms of neurodegenerative diseases such as frontotemporal dementia (FTD), Alzheimer's disease (AD), Parkinson's disease (PD) and amytrophic lateral sclerosis (ALS). Her lab utilizes patient iPSCs to model disease, advanced sequencing technologies and cutting-edge CRISPR technologies to develop first-in-class gene therapies for CNS diseases. The Clelland lab is committed to promoting equity and justice in science in medicine. One of the pillars of the Clelland lab is the mentoring and advancement of trainees from underrepresented backgrounds to become the next generation of scientific leaders.
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    Collapse Featured Content 
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis. Nat Immunol. 2026 Mar; 27(3):490-502. Hayashi F, Mittl K, Dandekar R, Gerdts J, Hassan E, Schubert RD, Oshiro L, Loudermilk R, Greenfield A, Augusto DG, Havton G, Anumarlu S, Surapaneni A, Ramesh A, Tran E, Koshal K, Kizer K, Dreux J, Cagalingan AK, Schustek F, Flood L, Moore T, Kirkemo LL, Fisher IJ, Cooper T, Harms M, Gomez R, University of California, San Francisco MS-EPIC Team, Clelland CD, Sibener L, Cree BAC, Hauser SL, Hollenbach JA, Gee M, Wilson MR, Zamvil SS, Sabatino JJ. PMID: 41644766; PMCID: PMC12956596.
      View in: PubMed   Mentions:
    2. Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice. bioRxiv. 2026 Jan 13. Davtyan H, Naguib S, Voskobiynyk Y, Chadarevian JP, Capocchi JK, Giacchino JL, Eskandari-Sedighi G, DeNittis V, Ford JB, Agababian A, Nguyen J, Chadarevian AL, Sutherland MS, Shabestari SK, Nana AL, Zhang J, Spina S, Wong MY, Grinberg LT, Seeley WW, Huang E, Clelland CD, Gong S, Fan L, Paz JT, Blurton-Jones M, Gan L. PMID: 41648346; PMCID: PMC12871286.
      View in: PubMed   Mentions:
    3. Efficient in vivo mammalian neuron editing using peptide-mediated CRISPR enzyme delivery. bioRxiv. 2025 Nov 29. Manohar BD, Travis M, Munjal V, Baehr CM, Rahnama LMA, Kang MH, Haddad RF, Asija K, Noel EA, Peddireddy N, Chouhan RS, Sharma R, Wyman SK, Krishnappa N, Killebrew DA, Li SH, Snow KJ, Byrne AK, Boosani CS, Otero PA, Bringas J, O'Brien AA, Rocco MT, Zimmerly MP, Gray I, Sran GK, Patel MI, Seidensticker EF, Saville E, Gaitan Y, Schmelzle AL, Subramanyam PNB, Samaranch L, Green JA, Wells KD, Ehrenberg AJ, Murray SA, Clelland CD, Murthy N, Lonser RR, Hadaczek P, Van Laar VS, Bankiewicz KS, Wilson RC. PMID: 41404605; PMCID: PMC12704004.
      View in: PubMed   Mentions:
    4. Measurement and clinical interpretation of CRISPR off-targets. Nat Genet. 2026 Jan; 58(1):20-27. Angelini Stewart A, Ahrens-Nicklas RC, Tsai SQ, Musunuru K, Giannikopoulos P, Clelland CD. PMID: 41286106; PMCID: PMC12927645.
      View in: PubMed   Mentions:
    5. PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation. bioRxiv. 2025 Oct 31. Zhang M, Letian A, Mohl GA, Kroke B, Arkelius K, Clelland CD, Goldberg EL, Singhal NS. PMID: 41278621; PMCID: PMC12636580.
      View in: PubMed   Mentions:
    6. A single-cell, long-read, isoform-resolved case-control study of FTD reveals cell-type-specific and broad splicing dysregulation in human brain. Cell Rep. 2025 Sep 23; 44(9):116198. Belchikov N, Hu W, Fan L, Joglekar A, He Y, Foord C, Jarroux J, Hsu J, Pollard S, Amin S, Prjibelski AD, Gong S, Zhang S, Giannelli R, Seelaar H, Tomescu AI, Ross ME, Li AN, Grinberg LT, Spina S, Miller BL, Cooper-Knock J, Snyder MP, Seeley WW, Rao-Ruiz P, Spijker S, Smit AB, Clelland CD, Gan L, Tilgner HU. PMID: 40913764; PMCID: PMC12558363.
      View in: PubMed   Mentions:    Fields:    
    7. Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD. Commun Biol. 2025 Jul 01; 8(1):971. Clelland CD, Fan L, Saloner R, Etchegaray JI, Altobelli CR, Salomonsson S, Maltos AM, Sachdev A, Zhu J, Lee SI, Li Y, Zhou Y, Le D, Wang C, Carling G, Kodama L, Sayed F, Perez-Bermejo JA, Geier EG, Yokoyama JS, Rosen H, Nana AL, Spina S, Grinberg LT, Seeley WW, Elahi F, Boxer AL, Arkin MR, Gan L. PMID: 40596721; PMCID: PMC12218935.
      View in: PubMed   Mentions: Translation:HumansAnimalsCells
    8. Discovery research in physiologically maintained deceased. Science. 2025 May; 388(6746):473-476. Pet DB, Parent B, Singhal NS, Clelland CD. PMID: 40310922; PMCID: PMC12309407.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference. Alzheimers Dement. 2025 May; 21(5):e70078. Frost B, Rowe JB, Akinyemi RO, Abisambra JF, Ashton NJ, Brendel M, Buée L, Butler D, Carrillo MC, Chung P, Clelland CD, DeVos SL, Diaz K, Edelmayer RM, Elahi FM, Ellajosyula R, Ewen C, Fontana IC, Galas MC, Hansson O, Höglinger G, Horie K, Ibanez A, Jacobs L, Maina MB, Malpetti M, McDade E, McEwan W, Montoliu-Gaya L, Mummery CJ, Orr ME, Rohrer JD, Rommel A, Sastre C, Spires-Jones TL, Tee BL, Viney TJ, Walker JM, Wegmann S, Wildsmith K, Yadav R, Mahinrad S, Sexton C. PMID: 40437880; PMCID: PMC12120264.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. nf-core/pacvar: a pipeline for analyzing long-read PacBio whole genome and repeat expansion sequencing data. Bioinformatics. 2025 Mar 29; 41(4). Jain T, Clelland C. PMID: 40098241; PMCID: PMC11964484.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Single-Molecule Sequencing of the C9orf72 Repeat Expansion in Patient iPSCs. Bio Protoc. 2024 Sep 05; 14(17):e5060. Tsai YC, Brown KA, Bernardi MT, Harting J, Clelland CD. PMID: 39282230; PMCID: PMC11393041.
      View in: PubMed   Mentions: 3  
    12. Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats. Proc Natl Acad Sci U S A. 2024 Jul 30; 121(31):e2220020121. Celona B, Salomonsson SE, Wu H, Dang B, Kratochvil HT, Clelland CD, DeGrado WF, Black BL. PMID: 39042693; PMCID: PMC11295049.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Pharmacoepidemiology evaluation of bumetanide as a potential candidate for drug repurposing for Alzheimer's disease. Alzheimers Dement. 2024 08; 20(8):5236-5246. Morales J, Gabriel N, Natarajan L, LaCroix AZ, Shadyab AH, Xu R, Silverman J, Feldman HH, Hernandez I, Powder for Pennies Collaboration. PMID: 39030734; PMCID: PMC11350022.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Reversal of C9orf72 mutation-induced transcriptional dysregulation and pathology in cultured human neurons by allele-specific excision. Proc Natl Acad Sci U S A. 2024 Apr 23; 121(17):e2307814121. Sachdev A, Gill K, Sckaff M, Birk AM, Aladesuyi Arogundade O, Brown KA, Chouhan RS, Issagholian-Lewin PO, Patel E, Watry HL, Bernardi MT, Keough KC, Tsai YC, Smith AST, Conklin BR, Clelland CD. PMID: 38621131; PMCID: PMC11047104.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Building CRISPR Gene Therapies for the Central Nervous System: A Review. JAMA Neurol. 2024 03 01; 81(3):283-290. Salomonsson SE, Clelland CD. PMID: 38285472; PMCID: PMC11164426.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    16. Validated assays for the quantification of C9orf72 human pathology. Sci Rep. 2024 01 08; 14(1):828. Salomonsson SE, Maltos AM, Gill K, Aladesuyi Arogundade O, Brown KA, Sachdev A, Sckaff M, Lam KJK, Fisher IJ, Chouhan RS, Van Laar VS, Marley CB, McLaughlin I, Bankiewicz KS, Tsai YC, Conklin BR, Clelland CD. PMID: 38191789; PMCID: PMC10774390.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    17. Novel avenues of tau research. Alzheimers Dement. 2024 03; 20(3):2240-2261. Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, Hansson O, Karch CM, Kolb HC, La Joie R, Lee SE, Matallana D, Miller BL, Onyike CU, Quiroz YT, Rexach JE, Rohrer JD, Rommel A, Sadri-Vakili G, Schindler SE, Schneider JA, Sperling RA, Teunissen CE, Weninger SC, Worley SL, Zheng H, Carrillo MC. PMID: 38170841; PMCID: PMC10984447.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    18. Functional characterization of Alzheimer's disease genetic variants in microglia. Nat Genet. 2023 10; 55(10):1735-1744. Yang X, Wen J, Yang H, Jones IR, Zhu X, Liu W, Li B, Clelland CD, Luo W, Wong MY, Ren X, Cui X, Song M, Liu H, Chen C, Eng N, Ravichandran M, Sun Y, Lee D, Van Buren E, Jiang MZ, Chan CSY, Ye CJ, Perera RM, Gan L, Li Y, Shen Y. PMID: 37735198; PMCID: PMC10939305.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    19. A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Nat Neurosci. 2022 09; 25(9):1149-1162. Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M. PMID: 35953545; PMCID: PMC9448678.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansCells
    20. Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro. Biomaterials. 2021 04; 271:120700. Chun C, Smith AST, Kim H, Kamenz DS, Lee JH, Lee JB, Mack DL, Bothwell M, Clelland CD, Kim DH. PMID: 33631652; PMCID: PMC8044026.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    21. Microglial microRNAs mediate sex-specific responses to tau pathology. Nat Neurosci. 2020 02; 23(2):167-171. Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC, Clelland CD, Cheng Z, Yu G, Li Q, Kosik KS, Gan L. PMID: 31873194; PMCID: PMC7394069.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    22. Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10172-10177. Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C, Zhan L, Cooper YA, Davalos D, Akassoglou K, Coppola G, Gan L. PMID: 30232263; PMCID: PMC6176614.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    23. Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease. Neurobiol Dis. 2014 Jun; 66:19-27. Choi ML, Begeti F, Oh JH, Lee SY, O'Keeffe GC, Clelland CD, Tyers P, Cho ZH, Kim YB, Barker RA. PMID: 24561069.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    24. Common cerebral networks associated with distinct deep brain stimulation targets for cluster headache. Cephalalgia. 2014 Mar; 34(3):224-30. Clelland CD, Zheng Z, Kim W, Bari A, Pouratian N. PMID: 24133007; PMCID: PMC4197053.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    25. Comprehensive review of stereotactic radiosurgery for medically and surgically refractory pituitary adenomas. Surg Neurol Int. 2012; 3(Suppl 2):S79-89. Kim W, Clelland C, Yang I, Pouratian N. PMID: 22826820; PMCID: PMC3400491.
      View in: PubMed   Mentions: 5  
    26. A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science. 2009 Jul 10; 325(5937):210-3. Clelland CD, Choi M, Romberg C, Clemenson GD, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, Bussey TJ. PMID: 19590004; PMCID: PMC2997634.
      View in: PubMed   Mentions: 825     Fields:    Translation:AnimalsCells
    27. Cell therapy in Huntington disease. Neurosurg Focus. 2008; 24(3-4):E9. Clelland CD, Barker RA, Watts C. PMID: 18341412.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
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