Ethan Weiss, MD

Title(s)Associate Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
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    Collapse Biography 
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    University of California, San FranciscoClinical Fellowship School of Medicine - Cardiology
    Johns Hopkins UniversityM.D.1996School of Medicine

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    Collapse Overview
    CLINICAL INTERESTS: Dr. Ethan Weiss is a cardiologist specializing in general cardiology. His special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young.

    RESEARCH INTERESTS: In his research, Dr. Weiss uses genetic models to better understand the mechanism of metabolic disorders such as obesity, fatty liver disease, and diabetes. He also studies the blood clotting system and has interest in identifying novel ways to safely block clots associated with diseases such as heart attack and stroke without causing an increase in bleeding.

    Collapse Research 
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    Growth hormone signaling and lipid metabolism in fatty liver disease
    NIH/NIDDK R01DK091276Sep 20, 2011 - Aug 31, 2016
    Role: Principal Investigator
    Thrombin Signaling in Hemostasis and Thrombosis
    NIH/NHLBI K08HL074922Dec 9, 2003 - Nov 30, 2007
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Corbit KC, Wilson CG, Lowe D, Tran JL, Vera NB, Clasquin M, Mattis AN, Weiss EJ. Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma. JCI Insight. 2019 Aug 08; 5. PMID: 31393852.
      View in: PubMed
    2. Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes. 2018 02; 67(2):208-221. PMID: 29203511.
      View in: PubMed
    3. Lee AP, Mulligan K, Schambelan M, Murphy EJ, Weiss EJ. Growth hormone receptor antagonism with pegvisomant in insulin resistant non-diabetic men: A phase II pilot study. F1000Res. 2017; 6:614. PMID: 28713554.
      View in: PubMed
    4. Corbit KC, Camporez JPG, Tran JL, Wilson CG, Lowe DA, Nordstrom SM, Ganeshan K, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. JCI Insight. 2017 02 09; 2(3):e91001. PMID: 28194444.
      View in: PubMed
    5. Wilson CG, Tran JL, Erion DM, Vera NB, Febbraio M, Weiss EJ. Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice. Endocrinology. 2016 Feb; 157(2):570-85. PMID: 26650570; PMCID: PMC4733118 [Available on 02/01/17].
    6. Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ. Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH. Mol Endocrinol. 2013 Aug; 27(8):1333-42. PMID: 23782652; PMCID: PMC4188962.
    7. Hsue PY, Scherzer R, Grunfeld C, Nordstrom SM, Schnell A, Kohl LP, Nitta E, Martin JN, Deeks SG, Weiss EJ. HIV infection is associated with decreased thrombin generation. Clin Infect Dis. 2012 Apr; 54(8):1196-203. PMID: 22438347; PMCID: PMC3309887.
    8. Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ. Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH. Mol Endocrinol. 2011 Jul; 25(7):1223-30. PMID: 21527499; PMCID: PMC3125097.
    9. Sos BC, Harris C, Nordstrom SM, Tran JL, Bal√°zs M, Caplazi P, Febbraio M, Applegate MA, Wagner KU, Weiss EJ. Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. J Clin Invest. 2011 Apr; 121(4):1412-23. PMID: 21364286; PMCID: PMC3069761.
    10. Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, Parise LV, Dauerman HL, French PA, Smyth SS, Becker RC. Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2372-84. PMID: 21084706; PMCID: PMC4118751.
    11. Nordstrom SM, Holliday BA, Sos BC, Smyth JW, Levy RE, Dukes JW, Lord ST, Weiss EJ. Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice. Blood. 2010 Dec 16; 116(25):5724-33. PMID: 20823455; PMCID: PMC3031416.
    12. Nordstrom SM, Weiss EJ. Sex differences in thrombosis. Expert Rev Hematol. 2008 Oct; 1(1):3-8. PMID: 21083002.
      View in: PubMed
    13. Wong JH, Dukes J, Levy RE, Sos B, Mason SE, Fong TS, Weiss EJ. Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns. J Clin Invest. 2008 Aug; 118(8):2969-78. PMID: 18618017; PMCID: PMC2447928.
    14. Weiss EJ, Hamilton JR, Lease KE, Coughlin SR. Protection against thrombosis in mice lacking PAR3. Blood. 2002 Nov 01; 100(9):3240-4. PMID: 12384423.
      View in: PubMed
    15. Goldschmidt-Clermont PJ, Coleman LD, Pham YM, Cooke GE, Shear WS, Weiss EJ, Kral BG, Moy TF, Yook RM, Blumenthal RS, Becker DM, Becker LC, Bray PF. Higher prevalence of GPIIIa PlA2 polymorphism in siblings of patients with premature coronary heart disease. Arch Pathol Lab Med. 1999 Dec; 123(12):1223-9. PMID: 10583927.
      View in: PubMed
    16. Bray PF, Weiss EJ, Tayback M, Goldschmidt-Clermont PJ. PlA1/A2 polymorphism of platelet glycoprotein IIIa and risk of cardiovascular disease. Lancet. 1997 Apr 12; 349(9058):1100-1. PMID: 9107268.
      View in: PubMed
    17. Vandervoort J, Weiss EJ, Somnay K, Tham TC, Wong RC, Carr-Locke DL. Self-expanding metal stent for obstructing adenocarcinoma of the sigmoid. Gastrointest Endosc. 1996 Dec; 44(6):739-41. PMID: 8979071.
      View in: PubMed
    18. Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, Weiss JL, Gerstenblith G, Goldschmidt-Clermont PJ. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med. 1996 Apr 25; 334(17):1090-4. PMID: 8598867.
      View in: PubMed
    19. Weiss EJ, Goldschmidt-Clermont PJ, Grigoryev D, Jin Y, Kickler TS, Bray PF. A monoclonal antibody (SZ21) specific for platelet GPIIIa distinguishes P1A1 from P1A2. Tissue Antigens. 1995 Nov; 46(5):374-81. PMID: 8838346.
      View in: PubMed