Elizabeth Murphy, MD, PhD

SchoolUCSF School of Medicine
Address1001 Potrero Ave, SFGH 100
San Francisco CA 94110
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    Collapse Education and Training
    University of California, San FranciscoFellowship2002Endocrinology and Metabolism
    University of California, San FranciscoInternship and Residency 1997Internal Medicine
    Harvard UniversityM.D.1994School of Medicine
    Oxford UniversityDPhil1989Biochemistry
    Wellesley CollegeBA1986Chemistry

    Collapse Overview 
    Collapse Overview
    Elizabeth Murphy, MD, DPhil, is Chief of the Endocrinology and Metabolism Division, Director of the Diabetes Center for High Risk Populations and Specialty Lead of the eReferral Program at San Francisco General Hospital and a Professor of Clinical Medicine at the University of California, San Francisco.

    As Chief of the Endocrinology and Metabolism Division at SFGH, Dr. Murphy's work has focused on improving access and quality of endocrinology and diabetes care for low income, diverse populations in the San Francisco safety net. As Director of the Diabetes Center for High Risk Populations, she has led the development of novel services such as medical group visits for insulin initiation in English and Spanish, low literacy insulin teaching aids for patients, medication management algorithms for primary care, and targeted outreach to SF County Jail patients. Her team’s efforts in health disparities were recognized by the American Diabetes Association’s Promising Practice Award of Excellence in 2012 and were an integral part of the Healthy San Francisco Chronic Care Redesign Program recognized by the National Association of Public Hospitals’ Safety Net Award in 2010.

    Through her work as Specialty Lead of the eReferral program, Dr. Murphy has been instrumental in standardizing the role of the specialist reviewer with an emphasis on improving primary-specialty care communication. In addition she has worked with the Endocrine Society on improving the referral process as part of the ACP High Value Care Coordination Project.

    Previously, Dr. Murphy served as the Chief Medical Officer of KineMed, Inc, a biotechnology company focused on the use of stable isotope technology to measure kinetic processes for drug development. There she was responsible for in vivo human studies in diverse areas including insulin resistance and diabetes, lipid metabolism, chronic lymphocytic leukemia, prostate cancer, and bile acid kinetics.

    A practicing endocrinologist, Dr. Murphy received the UCSF/San Francisco General Hospital Department of Medicine Subspecialty Consultant of the Year Award in 2011, the John Karum Clinician Educator Award in 2011 for her work with UCSF endocrinology fellows and in 2015 was named a Master Clinician in the Department of Medicine.

    Dr. Murphy received her BA in Chemistry from Wellesley College, a D.Phil. in Biochemistry from Oxford University as a Rhodes Scholar, and MD from Harvard Medical School in the Harvard-MIT affiliated Health Sciences and Technology program. She completed her internal medicine residency and endocrinology fellowship training at UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    A Novel Biomarker for Myelin Synthesis
    NIH/NINDS R43NS050887Feb 15, 2005 - Jul 31, 2005
    Role: Principal Investigator
    Kinetic Biomarker for CLL Prognosis
    NIH/NCI R44CA097686Aug 1, 2003 - Jul 31, 2010
    Role: Co-Principal Investigator
    Nmr Studies Of The Mechanisms Of Cell Injury
    NIH/NIEHS Z01ES010004
    Role: Principal Investigator
    Signaling Pathways Involved In Apoptosis
    NIH/NIEHS Z01ES050142
    Role: Principal Investigator
    Mechanism Of Cardioprotection In Females
    NIH/NIEHS Z01ES100327
    Role: Principal Investigator
    Biomarkers of Cardiotoxicity
    NIH/NIEHS Z01ES101565
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kuo CR, Quan J, Kim S, Tang AH, Heuerman DP, Murphy E. Group visits to encourage insulin initiation: targeting patient barriers. J Clin Nurs. 2017 Jun; 26(11-12):1705-1713. PMID: 27602873.
      View in: PubMed
    2. Murphy E, Neuberg DS, Rassenti LZ, Hayes G, Redd R, Emson C, Li K, Brown JR, Wierda WG, Turner S, Greaves AW, Zent CS, Byrd JC, McConnel C, Barrientos J, Kay N, Hellerstein MK, Chiorazzi N, Kipps TJ, Rai KR. Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia. Leukemia. 2017 Jun; 31(6):1348-1354. PMID: 28115735.
      View in: PubMed
    3. Ratanawongsa N, Chan LL, Fouts MM, Murphy E. The Challenges of Electronic Health Records and Diabetes Electronic Prescribing: Implications for Safety Net Care for Diverse Populations. J Diabetes Res. 2017; 2017:8983237. PMID: 28197420.
      View in: PubMed
    4. Tuvdendorj D, Munoz AO, Ruiz-Barros V, Schwarz JM, Montalto G, Chandalia M, Sowers LC, Rizzo M, Murphy E, Abate N. In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters. Atherosclerosis. 2016 Aug; 251:147-152. PMID: 27323227; PMCID: PMC4983221 [Available on 08/01/17].
    5. Marshall NE, Murphy E, King JC, Haas EK, Lim JY, Wiedrick J, Thornburg KL, Purnell JQ. Comparison of multiple methods to measure maternal fat mass in late gestation. Am J Clin Nutr. 2016 Apr; 103(4):1055-63. PMID: 26888714; PMCID: PMC4807697 [Available on 04/01/17].
    6. Tuot DS, Leeds K, Murphy E, Sarkar U, Lyles CR, Mekonnen T, Chen AH. Facilitators and barriers to implementing electronic referral and/or consultation systems: a qualitative study of 16 health organizations. BMC Health Serv Res. 2015 Dec 19; 15:568. PMID: 26687507; PMCID: PMC4684927.
    7. Epstein AE, Olshansky B, Naccarelli GV, Kennedy JI, Murphy E, Goldschlager N. Practical Management Guide for Clinicians Who Treat Patients with Amiodarone. Am J Med. 2016 May; 129(5):468-75. PMID: 26497904.
      View in: PubMed
    8. Stern RJ, Murphy E. Metformin as Initial Oral Therapy in Type 2 Diabetes. JAMA. 2015 Jun 23-30; 313(24):2484-5. PMID: 26103032.
      View in: PubMed
    9. Tuot DS, Murphy E, McCulloch CE, Leeds K, Chan E, Chen AH. Leveraging an electronic referral system to build a medical neighborhood. Healthc (Amst). 2015 Dec; 3(4):202-8. PMID: 26699344.
      View in: PubMed
    10. McDermott KA, Rao MR, Nagarathna R, Murphy E, Burke A, Nagendra RH, Hecht FM. A yoga intervention for type 2 diabetes risk reduction: a pilot randomized controlled trial. BMC Complement Altern Med. 2014 Jul 01; 14:212. PMID: 24980650; PMCID: PMC4096416.
    11. Saslow LR, Kim S, Daubenmier JJ, Moskowitz JT, Phinney SD, Goldman V, Murphy E, Cox RM, Moran P, Hecht FM. A randomized pilot trial of a moderate carbohydrate diet compared to a very low carbohydrate diet in overweight or obese individuals with type 2 diabetes mellitus or prediabetes. PLoS One. 2014; 9(4):e91027. PMID: 24717684; PMCID: PMC3981696.
    12. Tuvdendorj D, Chandalia M, Batbayar T, Saraf M, Beysen C, Murphy E, Abate N. Altered subcutaneous abdominal adipose tissue lipid synthesis in obese, insulin-resistant humans. Am J Physiol Endocrinol Metab. 2013 Oct 15; 305(8):E999-E1006. PMID: 23982159; PMCID: PMC3798696.
    13. Chen AH, Murphy E, Yee HF. eReferral--a new model for integrated care. N Engl J Med. 2013 Jun 27; 368(26):2450-3. PMID: 23802515.
      View in: PubMed
    14. Okeigwe I, Yeaton-Massey A, Kim S, Vargas JE, Murphy E. U-500R and aspart insulin for the treatment of severe insulin resistance in pregnancy associated with pregestational diabetes. J Perinatol. 2013 Mar; 33(3):235-8. PMID: 23443293.
      View in: PubMed
    15. Turner S, Voogt J, Davidson M, Glass A, Killion S, Decaris J, Mohammed H, Minehira K, Boban D, Murphy E, Luchoomun J, Awada M, Neese R, Hellerstein M. Measurement of reverse cholesterol transport pathways in humans: in vivo rates of free cholesterol efflux, esterification, and excretion. J Am Heart Assoc. 2012 Aug; 1(4):e001826. PMID: 23130164; PMCID: PMC3487360.
    16. Hayes GM, Simko J, Holochwost D, Kuchinsky K, Busch R, Misell L, Murphy E, Carroll P, Chan J, Shinohara K, Hellerstein MK. Regional cell proliferation in microdissected human prostate specimens after heavy water labeling in vivo: correlation with prostate epithelial cells isolated from seminal fluid. Clin Cancer Res. 2012 Jun 15; 18(12):3250-60. PMID: 22553345.
      View in: PubMed
    17. Beysen C, Murphy E, Deines K, Chan M, Tsang E, Glass A, Turner SM, Protasio J, Riiff T, Hellerstein MK. Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study. Diabetologia. 2012 Feb; 55(2):432-42. PMID: 22134839.
      View in: PubMed
    18. Wilson JP, Mulligan K, Fan B, Sherman JL, Murphy E, Tai VW, Powers CL, Marquez L, Ruiz-Barros V, Shepherd JA. Dual-energy X-ray absorptiometry-based body volume measurement for 4-compartment body composition. Am J Clin Nutr. 2012 Jan; 95(1):25-31. PMID: 22134952; PMCID: PMC3238462.
    19. Calissano C, Damle RN, Marsilio S, Yan XJ, Yancopoulos S, Hayes G, Emson C, Murphy E, Hellerstein MK, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Ivanovic I, Dozmorov IM, Roa S, Scharff MD, Li W, Chiorazzi N. Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells. Mol Med. 2011; 17(11-12):1374-82. PMID: 21968788; PMCID: PMC3321822.
    20. Brufau G, Stellaard F, Prado K, Bloks VW, Jonkers E, Boverhof R, Kuipers F, Murphy E. Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism. Hepatology. 2010 Oct; 52(4):1455-64. PMID: 20725912.
      View in: PubMed
    21. Brufau G, Bahr MJ, Staels B, Claudel T, Ockenga J, Böker KH, Murphy E, Prado K, Stellaard F, Manns MP, Kuipers F, Tietge UJ. Plasma bile acids are not associated with energy metabolism in humans. Nutr Metab (Lond). 2010 Sep 03; 7:73. PMID: 20815878; PMCID: PMC2942888.
    22. Stellaard F, Bloks VW, Burgerhof HG, Scheltema RA, Murphy E, Romijn HA, Smelt GH, Brufau G, Kuipers F. Two time-point assessment of bile acid kinetics in humans using stable isotopes. Isotopes Environ Health Stud. 2010 Sep; 46(3):325-36. PMID: 20645205.
      View in: PubMed
    23. Sarkar U, Handley MA, Gupta R, Tang A, Murphy E, Seligman HK, Shojania KG, Schillinger D. What happens between visits? Adverse and potential adverse events among a low-income, urban, ambulatory population with diabetes. Qual Saf Health Care. 2010 Jun; 19(3):223-8. PMID: 20378619.
      View in: PubMed
    24. Hayes GM, Busch R, Voogt J, Siah IM, Gee TA, Hellerstein MK, Chiorazzi N, Rai KR, Murphy E. Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: validation of a simplified method suitable for multi-center clinical studies. Leuk Res. 2010 Jun; 34(6):809-15. PMID: 19854509.
      View in: PubMed
    25. Calissano C, Damle RN, Hayes G, Murphy E, Hellerstein MK, Moreno C, Sison C, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Chiorazzi N. In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia. Blood. 2009 Nov 26; 114(23):4832-42. PMID: 19789386; PMCID: PMC2925477.
    26. Beysen C, Murphy E, Nagaraja H, Decaris M, Riiff T, Fong A, Hellerstein MK, Boyle PJ. A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes. J Lipid Res. 2008 Dec; 49(12):2657-63. PMID: 18641372.
      View in: PubMed
    27. Sarkar U, Handley MA, Gupta R, Tang A, Murphy E, Seligman HK, Shojania KG, Schillinger D. Use of an interactive, telephone-based self-management support program to identify adverse events among ambulatory diabetes patients. J Gen Intern Med. 2008 Apr; 23(4):459-65. PMID: 18373145; PMCID: PMC2359521.
    28. Goldschlager N, Epstein AE, Naccarelli GV, Olshansky B, Singh B, Collard HR, Murphy E. A practical guide for clinicians who treat patients with amiodarone: 2007. Heart Rhythm. 2007 Sep; 4(9):1250-9. PMID: 17765636.
      View in: PubMed
    29. Beysen C, Murphy E, McLaughlin T, Riiff T, Lamendola C, Turner HC, Awada M, Turner SM, Reaven G, Hellerstein MK. Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivo. Diabetes Care. 2007 May; 30(5):1143-9. PMID: 17259480.
      View in: PubMed
    30. Voogt JN, Awada M, Murphy E, Hayes GM, Busch R, Hellerstein MK. Measurement of very low rates of cell proliferation by heavy water labeling of DNA and gas chromatography/pyrolysis/isotope ratio-mass spectrometric analysis. Nat Protoc. 2007; 2(12):3058-62. PMID: 18079704.
      View in: PubMed
    31. Turner SM, Roy S, Sul HS, Neese RA, Murphy E, Samandi W, Roohk DJ, Hellerstein MK. Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1101-9. PMID: 17164440; PMCID: PMC2895312.
    32. Murphy E. Stable isotope methods for the in vivo measurement of lipogenesis and triglyceride metabolism. J Anim Sci. 2006 Apr; 84 Suppl:E94-104. PMID: 16582096.
      View in: PubMed
    33. Chen JL, Peacock E, Samady W, Turner SM, Neese RA, Hellerstein MK, Murphy E. Physiologic and pharmacologic factors influencing glyceroneogenic contribution to triacylglyceride glycerol measured by mass isotopomer distribution analysis. J Biol Chem. 2005 Jul 08; 280(27):25396-402. PMID: 15888453.
      View in: PubMed
    34. Messmer BT, Messmer D, Allen SL, Kolitz JE, Kudalkar P, Cesar D, Murphy E, Koduru P, Ferrarini M, Zupo S, Cutrona G, Damle RN, Wasil T, Rai KR, Hellerstein MK, Chiorazzi N. In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest. 2005 Mar; 115(3):755-64. PMID: 15711642; PMCID: PMC548318.
    35. Turner SM, Murphy E, Neese RA, Antelo F, Thomas T, Agarwal A, Go C, Hellerstein MK. Measurement of TG synthesis and turnover in vivo by 2H2O incorporation into the glycerol moiety and application of MIDA. Am J Physiol Endocrinol Metab. 2003 Oct; 285(4):E790-803. PMID: 12824084.
      View in: PubMed
    36. Murphy E, Davern TJ, Shakil AO, Shick L, Masharani U, Chow H, Freise C, Lee WM, Bass NM. Troglitazone-induced fulminant hepatic failure. Acute Liver Failure Study Group. Dig Dis Sci. 2000 Mar; 45(3):549-53. PMID: 10749332.
      View in: PubMed
    37. Murphy E. Doctor discontent. N Engl J Med. 1999 Feb 25; 340(8):650-1; author reply 652-3. PMID: 10049079.
      View in: PubMed
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