Shaun Coughlin, MD, PhD

Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #482J
San Francisco CA 94158
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    Other Positions
    Title(s)Director, Cardiovascular Research Institute

    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1986School of Medicine
    University of California, San Francisco Residency School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Structure-Function and Roles of Protease-Activated Receptors
    NIH R35HL135755Feb 14, 2017 - Oct 31, 2017
    Role: Principal Investigator
    Structural Basis of Protease-Activated Receptor Function
    NIH R01HL121387Jan 15, 2014 - Dec 31, 2017
    Role: Principal Investigator
    PARs and S1P receptors in endothelial biology
    NIH R01HL065590Sep 30, 2000 - Mar 31, 2015
    Role: Principal Investigator
    Thrombin signaling in Hemostatis and thrombosis
    NIH R01HL065185Sep 5, 2000 - Nov 30, 2012
    Role: Principal Investigator
    Protease-activated receptors in inflammation
    NIH R01HL059202Jan 1, 1998 - Mar 31, 2008
    Role: Principal Investigator
    Molecular Genetics of Cardiac Cell Differentiation
    NIH R01HL054737Apr 1, 1996 - Dec 31, 2016
    Role: Principal Investigator
    NIH P01DK050267Aug 15, 1995 - Jul 31, 2001
    Role: Co-Principal Investigator
    NIH R13HL050524Aug 1, 1993 - Jul 31, 1994
    Role: Principal Investigator
    Molecular and Cellular Basis of Cardiovascular Disease
    NIH T32HL007731Jul 1, 1992 - May 31, 2023
    Role: Principal Investigator
    Molecular Mechanisms of Protease Signaling
    NIH R01HL044907Apr 1, 1991 - Mar 31, 2010
    Role: Principal Investigator
    NIH R01HL043322Jul 1, 1989 - Apr 30, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models. PLoS One. 2022; 17(1):e0256512. Fu F, Pietropaolo M, Cui L, Pandit S, Li W, Tarnavski O, Shetty SS, Liu J, Lussier JM, Murakami Y, Grewal PK, Deyneko G, Turner GM, Taggart AKP, Waters MG, Coughlin S, Adachi Y. PMID: 34995278; PMCID: PMC8741011.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    2. Microglial Gi-dependent dynamics regulate brain network hyperexcitability. Nat Neurosci. 2021 01; 24(1):19-23. Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T, Acevedo RM, Cabriga B, Thomas R, Coughlin SR, Ellisman MH, Palop JJ, Akassoglou K. PMID: 33318667; PMCID: PMC8118167.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    3. Protease-Activated Receptor-2 Regulates Neuro-Epidermal Communication in Atopic Dermatitis. Front Immunol. 2020; 11:1740. Buhl T, Ikoma A, Kempkes C, Cevikbas F, Sulk M, Buddenkotte J, Akiyama T, Crumrine D, Camerer E, Carstens E, Schön MP, Elias P, Coughlin SR, Steinhoff M. PMID: 32903402; PMCID: PMC7435019.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    4. Designing a Green Fluorogenic Protease Reporter by Flipping a Beta Strand of GFP for Imaging Apoptosis in Animals. J Am Chem Soc. 2019 03 20; 141(11):4526-4530. Zhang Q, Schepis A, Huang H, Yang J, Ma W, Torra J, Zhang SQ, Yang L, Wu H, Nonell S, Dong Z, Kornberg TB, Coughlin SR, Shu X. PMID: 30821975; PMCID: PMC6486793.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    5. Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 10 02; 57(39):5748-5758. Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. PMID: 30102523; PMCID: PMC6584023.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    6. A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish. Dev Cell. 2018 07 02; 46(1):112-125.e4. Wu RS, Lam II, Clay H, Duong DN, Deo RC, Coughlin SR. PMID: 29974860.
      View in: PubMed   Mentions: 138     Fields:    Translation:AnimalsCells
    7. A rapid fluorogenic GPCR-β-arrestin interaction assay. Protein Sci. 2018 04; 27(4):874-879. Zhang Q, Zheng YW, Coughlin SR, Shu X. PMID: 29411438; PMCID: PMC5866937.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 01 18; 69(2):347. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. PMID: 29351851.
      View in: PubMed   Mentions: 11     Fields:    
    9. Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Sci Signal. 2018 01 16; 11(513). Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A. PMID: 29339534; PMCID: PMC5811261.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    10. Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent. Structure. 2018 02 06; 26(2):187-198.e4. Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL, Coughlin SR. PMID: 29336885; PMCID: PMC5803430.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 01 18; 69(2):334-346.e4. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. PMID: 29307513; PMCID: PMC5788022.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    12. Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. J Cell Biol. 2018 03 05; 217(3):1097-1112. Schepis A, Barker A, Srinivasan Y, Balouch E, Zheng Y, Lam I, Clay H, Hsiao CD, Coughlin SR. PMID: 29301867; PMCID: PMC5839797.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    13. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. PMID: 28329764; PMCID: PMC5663284.
      View in: PubMed   Mentions: 448     Fields:    Translation:AnimalsCells
    14. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circ Res. 2016 Sep 30; 119(8):e110-26. Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E. PMID: 27582371; PMCID: PMC5064286.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    15. Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis. Sci Transl Med. 2016 08 24; 8(353):353ra112. David T, Kim YC, Ely LK, Rondon I, Gao H, O'Brien P, Bolt MW, Coyle AJ, Garcia JL, Flounders EA, Mikita T, Coughlin SR. PMID: 27559095.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    16. Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis In Vivo. Cell Chem Biol. 2016 07 21; 23(7):875-882. To TL, Schepis A, Ruiz-González R, Zhang Q, Yu D, Dong Z, Coughlin SR, Shu X. PMID: 27447051; PMCID: PMC5026494.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    17. Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development. Dev Biol. 2016 10 01; 418(1):157-165. Clay H, Wilsbacher LD, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin SR. PMID: 27333774; PMCID: PMC5031538.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    18. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016 Apr 12; 7:11303. Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DYR, Gollob MH. PMID: 27066836; PMCID: PMC4832069.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    19. Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM. Nat Commun. 2015 Nov 12; 6:8857. Pfreundschuh M, Alsteens D, Wieneke R, Zhang C, Coughlin SR, Tampé R, Kobilka BK, Müller DJ. PMID: 26561004; PMCID: PMC4660198.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    20. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015 Oct 16; 4:e09406. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. PMID: 26473617; PMCID: PMC4720518.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    21. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nat Commun. 2015 Oct 01; 6:8448. Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS. PMID: 26423607; PMCID: PMC4593073.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    22. Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. 2015 Oct 22; 126(17):2047-58. Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin SR, Degen JL, Flick MJ. PMID: 26228483; PMCID: PMC4616238.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    23. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape. Nat Methods. 2015 Sep; 12(9):845-851. Alsteens D, Pfreundschuh M, Zhang C, Spoerri PM, Coughlin SR, Kobilka BK, Müller DJ. PMID: 26167642; PMCID: PMC5087271.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    24. Analysis of cardiomyocyte development using immunofluorescence in embryonic mouse heart. J Vis Exp. 2015 Mar 26; (97). Wilsbacher LD, Coughlin SR. PMID: 25866997; PMCID: PMC4401388.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2888-93. Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS. PMID: 25695968; PMCID: PMC4352814.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    26. Mechanical vessel injury in zebrafish embryos. J Vis Exp. 2015 Feb 17; (96):e52460. Clay H, Coughlin SR. PMID: 25742284; PMCID: PMC4354638.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    27. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 2014 Nov 27; 124(23):3450-8. Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. PMID: 25293779; PMCID: PMC4246040.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    28. Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2563-9. Bynagari-Settipalli YS, Cornelissen I, Palmer D, Duong D, Concengco C, Ware J, Coughlin SR. PMID: 25278288; PMCID: PMC4239193.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. The imperative to invest in science has never been greater. J Clin Invest. 2014 Sep; 124(9):3680-1. Carethers JM, Coughlin S, Diamond B, Erzurum S, Fried LP, Jameson JL, Kaushansky K, Klotman ME, Lemon S, Mitchell B, Rothman P, Sawyers C, Seidman C, Somlo S. PMID: 25180532; PMCID: PMC4151225.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 03; 502(7469):105-9. Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L. PMID: 23995678; PMCID: PMC3791160.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    31. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. PMID: 23657000; PMCID: PMC3720065.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    32. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012 Dec 20; 492(7429):387-92. Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. PMID: 23222541; PMCID: PMC3531875.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansCells
    33. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest. 2013 Jan; 123(1):206-14. Khoufache K, Berri F, Nacken W, Vogel AB, Delenne M, Camerer E, Coughlin SR, Carmeliet P, Lina B, Rimmelzwaan GF, Planz O, Ludwig S, Riteau B. PMID: 23202729; PMCID: PMC3533265.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    34. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell. 2012 Sep 28; 151(1):111-22. Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY. PMID: 23021219; PMCID: PMC3582364.
      View in: PubMed   Mentions: 219     Fields:    Translation:AnimalsCells
    35. Canadian Surgery Forum. Can J Surg. 2012 Aug; 55(4 Suppl 1):S63-S135. Fayez R, Roy M, Villeneuve S, AlMuntashery A, Demyttenaere S, Christou N, Court O, AlMuntashery A, Fayez R, Demyttenaere S, Christou N, Court O, Bodie G, Bonrath E, Hagen J, Okrainec A, Sullivan P, Grantcharov T, Almamar A, Sharma A, Karmali S, Birch DW, Gill RS, Majumdar SR, Wang X, Tuepah R, Klarenbach SW, Birch DW, Karmali S, Sharma AM, Padwal RJ, Raîche I, Smith C, Haggar F, Moloo H, Poulin EC, Martel G, Yelle JD, Mamazza J, Mueller CL, Jackson TD, Penner T, Pitzul K, Urbach DR, Okrainec A, AlMuntashery A, Villeneuve S, Roy M, Fayez R, Demyttenaere S, Christou N, Court O, Fayez R, Roy M, Villeneuve S, AlMuntashery A, Demyttenaere S, Christou N, Court O, AlMuntashery A, Fayez R, Demyttenaere S, Court O, Christou N, Moustarah F, Biertho L, Hould FS, Lebel S, Lescelleur O, Marceau S, Marceau P, Biron S, Khokhotva M, Grantcharov T, Anvari M, Sharma A, Yusuf S, Kwong J, Okrainec A, Pitzul KB, Urbach DR, Jackson T, Elkassem S, Lindsay D, Sullivan P, Smith L, Bonrath E, Zevin B, Dedy N, Grantcharov TP, Zevin B, Bonrath EM, Aggarwal R, Grantcharov T, Sockalingam S, Cassin S, Crawford S, Pitzul K, Khan A, Hawa R, Jackson T, Okrainec A, Smith C, Brar B, Mamazza J, Raîche I, Yelle JD, Haggar F, Moloo H, Smith C, Brar B, Haggar F, Dent R, Mamazza J, Raîche I, Moloo H, Whitlock KA, Gill RS, Ali T, Shi X, Birch DW, Karmali S, Gill RS, Whitlock KA, Shi X, Sarkhosh K, Birch DW, Karmali S, Suri M, Turner JM, Nation PN, Wizzard P, Brubaker PL, Gisalet DL, Wales PW, Palter VN, Grantcharov TP, Wakeam E, Tien H, Spencer F, Brenneman F, Khan RSA, Kowal J, Wiseman SM, Martelli V, Fraser SA, Vedel I, Deban M, Holcroft C, Monette M, Monette J, Bergman S, Malik A, Bell C, Stukel T, Urbach DR, Young PY, Mueller TF, Lucykx VA, Lukowski CM, Compston CA, Churchill TA, Khadaroo RG, Daigle C, Grantcharov T, McCreery G, Vogt K, Dubois L, Gray D, Seth R, Ananth A, Tai LH, Lam T, Falls T, Souza C, Bell J, Auer R, Paskar D, Crawford S, Parry N, Leslie K, Sudarshan M, Alhabboubi M, St-Louis E, Deckelbaum D, Razek T, Feldman LS, Khwaja K, Richardson D, Porter G, Johnson P, Haggar F, Boushey R, Moloo H, Raiche I, Mamazza J, Davis VW, Schiller DE, Eurich D, Sawyer MB, Rivard J, Vergis A, Unger B, Hardy K, Andrew C, Gillman L, Park J, Agzarian J, Prodger J, Kelly W, Kelly S, Prodger D, Racz J, Ewara E, Martin J, Sarma S, Chu M, Schlachta C, Zaric G, Winocour J, Al-Ali K, Briggs K, George R, Zilbert NR, Murnaghan ML, Leung A, Regehr G, Moulton CA, Decker C, Neumann K, Mahmud S, Metcalfe J, McKay A, Park J, Hochman D, Gosney JE, Burkle FM, Redmond AD, McQueen K, Wissanji H, Desrosiers E, Gilbert A, Chadi SA, Leslie K, Ott MC, Alhabboubi M, Sudarshan M, Jessula S, Alburakan A, Deckelbaum D, Razek T, Iqbal S, Khwaja K, Partridge E, Aikins C, Alhabboubi M, Sudarshan M, Deckelbaum D, Iqbal S, Khwaja K, Razek T, Olszewski M, Roberts N, Moulton CA, Murnaghan ML, Cil T, Chan R, Marshall J, Pederson K, Erichsen S, White J, Nadler A, Aarts MA, Okrainec A, Victor JC, Pearsall E, McLeod RS, Hameed U, Jackson TD, Okrainec A, Penner TP, Urbach DR, Brotherhood H, Karimuddin A, Hall C, Bawan S, Malik S, Hayashi A, Menezes AS, Gill RS, McAlister C, Zhang N, DesRosiers E, Mills A, Crozier M, Lee L, Maxwell J, Partridge E, Chad S, Steigerwald S, Mapiour D, Roberts D, MacPherson C, Donahoe L, MacDonald B, Mercer D, Hopman W, Rakovich G, Latulippe JF, Hilsden R, Knowles S, Moffat B, Parry N, Leslie K, Merani S, Switzer N, Khadaroo RG, Tul Y, Widder S, Davis P, Molinari M, Levy A, Johnson P, Davis PJB, Bailey J, Molinari M, Hayden J, Johnson P, Cools-Lartigue J, Benlolo S, Marcus V, Ferri L, Ojah J, Finley R, Anderson D, Julien F, Gagné JP, Carter D, Chan S, Wong S, Li J, Michael A, Choi D, Liu E, Hoogenes J, Dath D, Pitt D, Aubin JM, Banks BA, Mew D, McConnell Y, Rudovics A, Classen D, Kanthan S, Ravichandran P, Croome KP, Kovacs MJ, Lazo-Langner A, Hernandez-Alejandro R, Anantha R, Vogt K, Crawford S, Parry N, Leslie K, Aad I, Kholdebarin R, Khoshgoo N, Iwasiow BM, et al. PMID: 35488395; PMCID: PMC3432251.
      View in: PubMed   Mentions:    Fields:    
    36. Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20101-6. Regard JB, Cherman N, Palmer D, Kuznetsov SA, Celi FS, Guettier JM, Chen M, Bhattacharyya N, Wess J, Coughlin SR, Weinstein LS, Collins MT, Robey PG, Yang Y. PMID: 22106277; PMCID: PMC3250124.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    37. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science. 2011 Sep 30; 333(6051):1898-903. Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. PMID: 21960637; PMCID: PMC3267326.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    38. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood. 2011 Oct 13; 118(15):4015-23. Shao B, Wahrenbrock MG, Yao L, David T, Coughlin SR, Xia L, Varki A, McEver RP. PMID: 21860019; PMCID: PMC3204725.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
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    67. Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets. J Thromb Haemost. 2004 Aug; 2(8):1429-35. Hamilton JR, Cornelissen I, Coughlin SR. PMID: 15304051.
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    68. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood. 2004 Jul 15; 104(2):397-401. Camerer E, Qazi AA, Duong DN, Cornelissen I, Advincula R, Coughlin SR. PMID: 15031212.
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    69. Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. J Biol Chem. 2004 Apr 30; 279(18):18592-9. Ludeman MJ, Zheng YW, Ishii K, Coughlin SR. PMID: 14982936.
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    70. Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency. Blood. 2004 Jan 01; 103(1):152-4. Camerer E, Duong DN, Hamilton JR, Coughlin SR. PMID: 14504091.
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    72. The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. J Biol Chem. 2003 Aug 15; 278(33):30975-84. Eisenhaure TM, Francis SA, Willison LD, Coughlin SR, Lerner DJ. PMID: 12773540.
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    73. PARticipation in inflammation. J Clin Invest. 2003 Jan; 111(1):25-7. Coughlin SR, Camerer E. PMID: 12511583; PMCID: PMC151847.
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    75. Protease-activated receptors in the cardiovascular system. Cold Spring Harb Symp Quant Biol. 2002; 67:197-208. Coughlin SR. PMID: 12858541.
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    76. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature. 2001 Sep 06; 413(6851):74-8. Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR. PMID: 11544528.
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    77. Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J Immunol. 2000 Dec 01; 165(11):6504-10. Lindner JR, Kahn ML, Coughlin SR, Sambrano GR, Schauble E, Bernstein D, Foy D, Hafezi-Moghadam A, Ley K. PMID: 11086091.
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    78. Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. J Biol Chem. 2000 Oct 06; 275(40):31255-65. Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. PMID: 10893235.
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    79. Thrombin signalling and protease-activated receptors. Nature. 2000 Sep 14; 407(6801):258-64. Coughlin SR. PMID: 11001069.
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    80. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. J Biol Chem. 2000 Aug 25; 275(34):26333-42. Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS. PMID: 10831593.
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    82. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function. J Biol Chem. 2000 Jun 30; 275(26):19728-34. Faruqi TR, Weiss EJ, Shapiro MJ, Huang W, Coughlin SR. PMID: 10779527.
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    83. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5255-60. Camerer E, Huang W, Coughlin SR. PMID: 10805786; PMCID: PMC25815.
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    84. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol. 2000 May; 18(10):2095-103. Shepherd FA, Dancey J, Ramlau R, Mattson K, Gralla R, O'Rourke M, Levitan N, Gressot L, Vincent M, Burkes R, Coughlin S, Kim Y, Berille J. PMID: 10811675.
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    85. PAR3 is a cofactor for PAR4 activation by thrombin. Nature. 2000 Apr 06; 404(6778):609-13. Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR. PMID: 10766244.
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    86. Cathepsin G activates protease-activated receptor-4 in human platelets. J Biol Chem. 2000 Mar 10; 275(10):6819-23. Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR. PMID: 10702240.
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    87. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med. 2000 Feb 07; 191(3):455-62. Cunningham MA, Rondeau E, Chen X, Coughlin SR, Holdsworth SR, Tipping PG. PMID: 10662791; PMCID: PMC2195821.
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    88. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Blood. 1999 Dec 15; 94(12):4112-21. Kahn ML, Diacovo TG, Bainton DF, Lanza F, Trejo J, Coughlin SR. PMID: 10590056.
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    89. How the protease thrombin talks to cells. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11023-7. Coughlin SR. PMID: 10500117; PMCID: PMC34235.
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    90. Protease-activated receptors and platelet function. Thromb Haemost. 1999 Aug; 82(2):353-6. Coughlin SR. PMID: 10605724.
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    91. Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail. Biochemistry. 1999 Jul 20; 38(29):9308-16. Hammes SR, Shapiro MJ, Coughlin SR. PMID: 10413505.
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    92. The carboxyl tail of protease-activated receptor-1 is required for chemotaxis. Correlation of signal termination and directional migration. J Biol Chem. 1999 Jul 16; 274(29):20178-84. Sambrano GR, Coughlin SR. PMID: 10400633.
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    93. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar; 103(6):879-87. Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. PMID: 10079109; PMCID: PMC408153.
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    94. Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand. Biochemistry. 1999 Feb 23; 38(8):2486-93. Hammes SR, Coughlin SR. PMID: 10029543.
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    95. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem. 1999 Jan 22; 274(4):2216-24. Trejo J, Coughlin SR. PMID: 9890984.
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    96. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13698-702. Trejo J, Hammes SR, Coughlin SR. PMID: 9811863; PMCID: PMC24882.
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    97. Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1. J Biol Chem. 1998 Oct 30; 273(44):29009-14. Shapiro MJ, Coughlin SR. PMID: 9786906.
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    98. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. J Biol Chem. 1998 Sep 04; 273(36):23290-6. Kahn ML, Hammes SR, Botka C, Coughlin SR. PMID: 9722561.
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    99. A dual thrombin receptor system for platelet activation. Nature. 1998 Aug 13; 394(6694):690-4. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin SR. PMID: 9716134.
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    100. Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Blood. 1998 Jun 01; 91(11):4152-7. Ishihara H, Zeng D, Connolly AJ, Tam C, Coughlin SR. PMID: 9596661.
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    101. Sol Sherry lecture in thrombosis: how thrombin 'talks' to cells: molecular mechanisms and roles in vivo. Arterioscler Thromb Vasc Biol. 1998 Apr; 18(4):514-8. Coughlin SR. PMID: 9555855.
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    102. A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry. J Biol Chem. 1998 Feb 20; 273(8):4666-71. Bernstein HS, Coughlin SR. PMID: 9468527.
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    103. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett. 1997 Nov 17; 417(3):279-82. An S, Bleu T, Huang W, Hallmark OG, Coughlin SR, Goetzl EJ. PMID: 9409733.
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    104. Mice lacking the thrombin receptor, PAR1, have normal skin wound healing. Am J Pathol. 1997 Nov; 151(5):1199-204. Connolly AJ, Suh DY, Hunt TK, Coughlin SR. PMID: 9358744; PMCID: PMC1858088.
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    105. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 1997 Apr 03; 386(6624):502-6. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR. PMID: 9087410.
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    106. The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors. J Biol Chem. 1997 Mar 14; 272(11):6898-902. Verrall S, Ishii M, Chen M, Wang L, Tram T, Coughlin SR. PMID: 9054376.
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    107. Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. J Biol Chem. 1997 Feb 28; 272(9):5833-7. Bernstein HS, Coughlin SR. PMID: 9038199.
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    108. Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation. J Biol Chem. 1997 Feb 28; 272(9):6011-7. Molino M, Bainton DF, Hoxie JA, Coughlin SR, Brass LF. PMID: 9038223.
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    109. Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. J Biol Chem. 1996 Dec 20; 271(51):32874-80. Shapiro MJ, Trejo J, Zeng D, Coughlin SR. PMID: 8955127.
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    110. Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. J Immunol. 1996 Dec 15; 157(12):5606-12. Franci C, Gosling J, Tsou CL, Coughlin SR, Charo IF. PMID: 8955213.
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    111. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem. 1996 Aug 30; 271(35):21536-41. Trejo J, Connolly AJ, Coughlin SR. PMID: 8702939.
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    112. Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes. Circ Res. 1996 Aug; 79(2):286-94. Kranzhöfer R, Clinton SK, Ishii K, Coughlin SR, Fenton JW, Libby P. PMID: 8756006.
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    113. Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function. J Biol Chem. 1996 Jun 14; 271(24):13943-7. Lerner DJ, Chen M, Tram T, Coughlin SR. PMID: 8662993.
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    114. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 1996 Jun 06; 381(6582):516-9. Connolly AJ, Ishihara H, Kahn ML, Farese RV, Coughlin SR. PMID: 8632823.
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    115. Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster. Mol Med. 1996 May; 2(3):349-57. Kahn M, Ishii K, Kuo WL, Piper M, Connolly A, Shi YP, Wu R, Lin CC, Coughlin SR. PMID: 8784787; PMCID: PMC2230143.
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    122. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. J Biol Chem. 1994 Nov 04; 269(44):27719-26. Hein L, Ishii K, Coughlin SR, Kobilka BK. PMID: 7961693.
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    143. Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Semin Thromb Hemost. 1992; 18(2):161-6. Coughlin SR, Vu TK, Hung DT, Wheaton VI. PMID: 1321504.
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    144. Thrombin receptor structure and function. Cold Spring Harb Symp Quant Biol. 1992; 57:149-54. Coughlin SR, Scarborough RM, Vu TK, Hung DT. PMID: 1339654.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    145. Domains specifying thrombin-receptor interaction. Nature. 1991 Oct 17; 353(6345):674-7. Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR. PMID: 1717851.
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    146. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest. 1991 Oct; 88(4):1121-7. Nelken NA, Coughlin SR, Gordon D, Wilcox JN. PMID: 1843454; PMCID: PMC295565.
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    147. The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem. 1991 Sep 15; 266(26):16977-80. Liu LW, Vu TK, Esmon CT, Coughlin SR. PMID: 1654318.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    148. cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins. J Biol Chem. 1991 Jun 05; 266(16):10638-45. Lanza F, Wolf D, Fox CF, Kieffer N, Seyer JM, Fried VA, Coughlin SR, Phillips DR, Jennings LK. PMID: 2037603.
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    149. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991 Mar 22; 64(6):1057-68. Vu TK, Hung DT, Wheaton VI, Coughlin SR. PMID: 1672265.
      View in: PubMed   Mentions: 660     Fields:    Translation:HumansAnimalsCells
    150. Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science. 1989 Mar 03; 243(4895):1191-4. Coughlin SR, Escobedo JA, Williams LT. PMID: 2466336.
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    151. Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway. Mol Endocrinol. 1988 Jul; 2(7):599-605. Kavanaugh WM, Williams LT, Ives HE, Coughlin SR. PMID: 2842665.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    152. A common PDGF receptor is activated by homodimeric A and B forms of PDGF. Science. 1988 Jun 10; 240(4858):1532-4. Escobedo JA, Navankasatussas S, Cousens LS, Coughlin SR, Bell GI, Williams LT. PMID: 2836953.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    153. Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo. J Biol Chem. 1988 Jan 15; 263(2):988-93. Coughlin SR, Barr PJ, Cousens LS, Fretto LJ, Williams LT. PMID: 2447083.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    154. Molecular mechanisms of platelet-derived growth factor action. Prog Clin Biol Res. 1988; 266:39-45. Coughlin SR, Escobedo JA, Williams LT. PMID: 2837788.
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    155. Arachidonic acid and cyclic adenosine monophosphate stimulation of c-fos expression by a pathway independent of phorbol ester-sensitive protein kinase C. Mol Endocrinol. 1988 Jan; 2(1):73-7. Kacich RL, Williams LT, Coughlin SR. PMID: 2840568.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    156. Signal transduction by the platelet-derived growth factor receptor. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:455-65. Williams LT, Escobedo JA, Keating MT, Coughlin SR. PMID: 2855486.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    157. The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor. J Cell Physiol Suppl. 1987; Suppl 5:27-30. Williams LT, Escobedo JA, Keating MT, Coughlin SR. PMID: 2824531.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    158. Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8348-50. Starksen NF, Simpson PC, Bishopric N, Coughlin SR, Lee WM, Escobedo JA, Williams LT. PMID: 3022291; PMCID: PMC386925.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    159. Dual trophic effects of the alpha 1-adrenergic receptor in cultured neonatal rat heart muscle cells. J Mol Cell Cardiol. 1986 Nov; 18 Suppl 5:45-58. Simpson P, Bishopric N, Coughlin S, Karliner J, Ordahl C, Starksen N, Tsao T, White N, Williams L. PMID: 3027351.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    160. c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF. Cell. 1985 Nov; 43(1):243-51. Coughlin SR, Lee WM, Williams PW, Giels GM, Williams LT. PMID: 3000601.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    161. Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor. Nature. 1980 Dec 11; 288(5791):600-2. Coughlin SR, Moskowitz MA, Zetter BR, Antoniades HN, Levine L. PMID: 7003399.
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