Loading...

Shaun Coughlin, MD, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentCardiovascular Research Inst
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-502-8667
vCardDownload vCard
    Other Positions
    TitleDirector, Cardiovascular Research Institute
    InstitutionUCSF School of Medicine
    DepartmentCardiovascular Research Inst


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1986School of Medicine
    University of California, San Francisco Residency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Structure-Function and Roles of Protease-Activated Receptors
    NIH/NHLBI R35HL135755Feb 14, 2017 - Dec 31, 2023
    Role: Principal Investigator
    Structural Basis of Protease-Activated Receptor Function
    NIH/NHLBI R01HL121387Jan 15, 2014 - Dec 31, 2017
    Role: Principal Investigator
    PARs and S1P receptors in endothelial biology
    NIH/NHLBI R01HL065590Sep 30, 2000 - May 31, 2014
    Role: Principal Investigator
    Thrombin signaling in Hemostatis and thrombosis
    NIH/NHLBI R01HL065185Sep 5, 2000 - Nov 30, 2012
    Role: Principal Investigator
    Protease-activated receptors in inflammation
    NIH/NHLBI R01HL059202Jan 1, 1998 - Mar 31, 2008
    Role: Principal Investigator
    Molecular Genetics of Cardiac Cell Differentiation
    NIH/NHLBI R01HL054737Apr 1, 1996 - Jun 30, 2016
    Role: Principal Investigator
    MURINE MODELS TO INVESTIGATE THE HEMATOLOGIC SYSTEM
    NIH/NIDDK P01DK050267Aug 15, 1995 - Jul 31, 2001
    Role: Co-Principal Investigator
    GORDON CONFERENCE--ATHEROSCLEROSIS 1993
    NIH/NHLBI R13HL050524Aug 1, 1993 - Jul 31, 1994
    Role: Principal Investigator
    Molecular and Cellular Basis of Cardiovascular Disease
    NIH/NHLBI T32HL007731Jul 1, 1992 - Aug 31, 2017
    Role: Principal Investigator
    Molecular Mechanisms of Protease Signaling
    NIH/NHLBI R01HL044907Apr 1, 1991 - Mar 31, 2010
    Role: Principal Investigator
    CELL AND MOLECULES MEDIATING GRAFT ATHEROSCLEROSIS
    NIH/NHLBI R01HL043322Jul 1, 1989 - Apr 30, 1994
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin S, Krummel MF, Leavitt AD, Passegué E, Looney MR. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. PMID: 28329764.
      View in: PubMed
    2. Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin S, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circ Res. 2016 Sep 30; 119(8):e110-26. PMID: 27582371.
      View in: PubMed
    3. David T, Kim YC, Ely LK, Rondon I, Gao H, O'Brien P, Bolt MW, Coyle AJ, Garcia JL, Flounders EA, Mikita T, Coughlin S. Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis. Sci Transl Med. 2016 Aug 24; 8(353):353ra112. PMID: 27559095.
      View in: PubMed
    4. To TL, Schepis A, Ruiz-González R, Zhang Q, Yu D, Dong Z, Coughlin S, Shu X. Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis In Vivo. Cell Chem Biol. 2016 Jul 21; 23(7):875-82. PMID: 27447051; PMCID: PMC5026494 [Available on 01/21/17].
    5. Clay H, Wilsbacher LD, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin S. Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development. Dev Biol. 2016 Oct 01; 418(1):157-165. PMID: 27333774.
      View in: PubMed
    6. Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin S, Stainier DY, Gollob MH. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016 Apr 12; 7:11303. PMID: 27066836; PMCID: PMC4832069.
    7. Pfreundschuh M, Alsteens D, Wieneke R, Zhang C, Coughlin S, Tampé R, Kobilka BK, Müller DJ. Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM. Nat Commun. 2015 Nov 12; 6:8857. PMID: 26561004; PMCID: PMC4660198.
    8. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin S, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015 Oct 16; 4:e09406. PMID: 26473617; PMCID: PMC4720518.
    9. Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin S, Craik CS. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nat Commun. 2015 Oct 01; 6:8448. PMID: 26423607; PMCID: PMC4593073.
    10. Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin S, Degen JL, Flick MJ. Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. 2015 Oct 22; 126(17):2047-58. PMID: 26228483; PMCID: PMC4616238.
    11. Wilsbacher LD, Coughlin S. Analysis of cardiomyocyte development using immunofluorescence in embryonic mouse heart. J Vis Exp. 2015 Mar 26; (97). PMID: 25866997; PMCID: PMC4401388.
    12. Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin S, Conklin BR, Deneris ES, Tecott LH, German MS. Gai/o-coupled receptor signaling restricts pancreatic ß-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2888-93. PMID: 25695968; PMCID: PMC4352814.
    13. Clay H, Coughlin S. Mechanical vessel injury in zebrafish embryos. J Vis Exp. 2015 Feb 17; (96):e52460. PMID: 25742284; PMCID: PMC4354638.
    14. Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 2014 Nov 27; 124(23):3450-8. PMID: 25293779; PMCID: PMC4246040.
    15. Bynagari-Settipalli YS, Cornelissen I, Palmer D, Duong D, Concengco C, Ware J, Coughlin S. Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2563-9. PMID: 25278288; PMCID: PMC4239193.
    16. Carethers JM, Coughlin S, Diamond B, Erzurum S, Fried LP, Jameson JL, Kaushansky K, Klotman ME, Lemon S, Mitchell B, Rothman P, Sawyers C, Seidman C, Somlo S. The imperative to invest in science has never been greater. J Clin Invest. 2014 Sep; 124(9):3680-1. PMID: 25180532; PMCID: PMC4151225.
    17. Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin S, McEver RP, Chen H, Kahn ML, Xia L. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 03; 502(7469):105-9. PMID: 23995678; PMCID: PMC3791160.
    18. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin S, McDonald DM, McCune JM. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83. PMID: 23657000; PMCID: PMC3720065.
    19. Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin S, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012 Dec 20; 492(7429):387-92. PMID: 23222541; PMCID: PMC3531875.
    20. Khoufache K, Berri F, Nacken W, Vogel AB, Delenne M, Camerer E, Coughlin S, Carmeliet P, Lina B, Rimmelzwaan GF, Planz O, Ludwig S, Riteau B. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest. 2013 Jan; 123(1):206-14. PMID: 23202729; PMCID: PMC3533265.
    21. Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin S, Jan YN, Jan LY. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell. 2012 Sep 28; 151(1):111-22. PMID: 23021219; PMCID: PMC3582364.
    22. Regard JB, Cherman N, Palmer D, Kuznetsov SA, Celi FS, Guettier JM, Chen M, Bhattacharyya N, Wess J, Coughlin S, Weinstein LS, Collins MT, Robey PG, Yang Y. Wnt/ß-catenin signaling is differentially regulated by Ga proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20101-6. PMID: 22106277; PMCID: PMC3250124.
    23. Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science. 2011 Sep 30; 333(6051):1898-903. PMID: 21960637; PMCID: PMC3267326.
    24. Shao B, Wahrenbrock MG, Yao L, David T, Coughlin S, Xia L, Varki A, McEver RP. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood. 2011 Oct 13; 118(15):4015-23. PMID: 21860019; PMCID: PMC3204725.
    25. Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin S, Cyster JG. The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011 Jun 05; 12(7):672-80. PMID: 21642988; PMCID: PMC3158008.
    26. Frateschi S, Camerer E, Crisante G, Rieser S, Membrez M, Charles RP, Beermann F, Stehle JC, Breiden B, Sandhoff K, Rotman S, Haftek M, Wilson A, Ryser S, Steinhoff M, Coughlin S, Hummler E. PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nat Commun. 2011 Jan 18; 2:161. PMID: 21245842.
      View in: PubMed
    27. Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin S. Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18605-10. PMID: 20930120; PMCID: PMC2972928.
    28. Eagle KA, Ginsburg GS, Musunuru K, Aird WC, Balaban RS, Bennett SK, Blumenthal RS, Coughlin S, Davidson KW, Frohlich ED, Greenland P, Jarvik GP, Libby P, Pepine CJ, Ruskin JN, Stillman AE, Van Eyk JE, Tolunay HE, McDonald CL, Smith SC. Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group. Circulation. 2010 Mar 30; 121(12):1447-54. PMID: 20351302; PMCID: PMC2905873.
    29. Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, Kirchhofer D, Coughlin S. Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010 Jan 19; 18(1):25-38. PMID: 20152175; PMCID: PMC2822780.
    30. Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin S, McDonald DM, Schwab SR, Cyster JG. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med. 2010 Jan 18; 207(1):17-27. PMID: 20026661; PMCID: PMC2812554.
    31. Camerer E, Regard JB, Cornelissen I, Srinivasan Y, Duong DN, Palmer D, Pham TH, Wong JS, Pappu R, Coughlin S. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest. 2009 Jul; 119(7):1871-9. PMID: 19603543; PMCID: PMC2701879.
    32. Hamilton JR, Cornelissen I, Mountford JK, Coughlin S. Atherosclerosis proceeds independently of thrombin-induced platelet activation in ApoE-/- mice. Atherosclerosis. 2009 Aug; 205(2):427-32. PMID: 19217621; PMCID: PMC2717183.
    33. Li G, Kataoka H, Coughlin S, Pleasure SJ. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development. 2009 Jan; 136(2):327-35. PMID: 19103804; PMCID: PMC2685973.
    34. Regard JB, Sato IT, Coughlin S. Anatomical profiling of G protein-coupled receptor expression. Cell. 2008 Oct 31; 135(3):561-71. PMID: 18984166; PMCID: PMC2590943.
    35. Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol. 2008 Jun 30; 181(7):1211-22. PMID: 18573917; PMCID: PMC2442211.
    36. Sood R, Sholl L, Isermann B, Zogg M, Coughlin S, Weiler H. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. Blood. 2008 Aug 01; 112(3):585-91. PMID: 18490515; PMCID: PMC2481555.
    37. Cho J, Furie BC, Coughlin S, Furie B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest. 2008 Mar; 118(3):1123-31. PMID: 18292814; PMCID: PMC2248441.
    38. Regard JB, Kataoka H, Cano DA, Camerer E, Yin L, Zheng YW, Scanlan TS, Hebrok M, Coughlin S. Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest. 2007 Dec; 117(12):4034-43. PMID: 17992256; PMCID: PMC2066199.
    39. Sood R, Zogg M, Westrick RJ, Guo YH, Kerschen EJ, Girardi G, Salmon JE, Coughlin S, Weiler H. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. J Exp Med. 2007 May 14; 204(5):1049-56. PMID: 17438064; PMCID: PMC2118565.
    40. Cottrell GS, Amadesi S, Pikios S, Camerer E, Willardsen JA, Murphy BR, Caughey GH, Wolters PJ, Coughlin S, Peterson A, Knecht W, Pothoulakis C, Bunnett NW, Grady EF. Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology. 2007 Jun; 132(7):2422-37. PMID: 17570216; PMCID: PMC2366898.
    41. Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, Coughlin S. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science. 2007 Apr 13; 316(5822):295-8. PMID: 17363629.
      View in: PubMed
    42. Vandendries ER, Hamilton JR, Coughlin S, Furie B, Furie BC. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):288-92. PMID: 17190826; PMCID: PMC1765451.
    43. De Candia E, Pecci A, Ciabattoni G, De Cristofaro R, Rutella S, Yao-Wu Z, Lazzareschi I, Landolfi R, Coughlin S, Balduini CL. Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. J Thromb Haemost. 2007 Mar; 5(3):551-9. PMID: 17137471.
      View in: PubMed
    44. Yuan J, Stein DA, Lim T, Qiu D, Coughlin S, Liu Z, Wang Y, Blouch R, Moulton HM, Iversen PL, Yang D. Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site. J Virol. 2006 Dec; 80(23):11510-9. PMID: 16987987; PMCID: PMC1642606.
    45. Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin S. Roles of protease-activated receptors in a mouse model of endotoxemia. Blood. 2006 May 15; 107(10):3912-21. PMID: 16434493; PMCID: PMC1895289.
    46. Su X, Camerer E, Hamilton JR, Coughlin S, Matthay MA. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005 Aug 15; 175(4):2598-605. PMID: 16081834.
      View in: PubMed
    47. Coughlin S. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost. 2005 Aug; 3(8):1800-14. PMID: 16102047.
      View in: PubMed
    48. Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin S. Essential role for Galpha13 in endothelial cells during embryonic development. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8281-6. PMID: 15919816; PMCID: PMC1149452.
    49. Ludeman MJ, Kataoka H, Srinivasan Y, Esmon NL, Esmon CT, Coughlin S. PAR1 cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 2005 Apr 01; 280(13):13122-8. PMID: 15665002.
      View in: PubMed
    50. Hamilton JR, Cornelissen I, Coughlin S. Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets. J Thromb Haemost. 2004 Aug; 2(8):1429-35. PMID: 15304051.
      View in: PubMed
    51. Camerer E, Qazi AA, Duong DN, Cornelissen I, Advincula R, Coughlin S. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood. 2004 Jul 15; 104(2):397-401. PMID: 15031212.
      View in: PubMed
    52. Ludeman MJ, Zheng YW, Ishii K, Coughlin S. Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. J Biol Chem. 2004 Apr 30; 279(18):18592-9. PMID: 14982936.
      View in: PubMed
    53. Camerer E, Duong DN, Hamilton JR, Coughlin S. Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency. Blood. 2004 Jan 01; 103(1):152-4. PMID: 14504091.
      View in: PubMed
    54. Kataoka H, Hamilton JR, McKemy DD, Camerer E, Zheng YW, Cheng A, Griffin C, Coughlin S. Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood. 2003 Nov 01; 102(9):3224-31. PMID: 12869501.
      View in: PubMed
    55. Eisenhaure TM, Francis SA, Willison LD, Coughlin S, Lerner DJ. The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. J Biol Chem. 2003 Aug 15; 278(33):30975-84. PMID: 12773540.
      View in: PubMed
    56. Coughlin S, Camerer E. PARticipation in inflammation. J Clin Invest. 2003 Jan; 111(1):25-7. PMID: 12511583; PMCID: PMC151847.
    57. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin S, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. PMID: 12478301.
      View in: PubMed
    58. Weiss EJ, Hamilton JR, Lease KE, Coughlin S. Protection against thrombosis in mice lacking PAR3. Blood. 2002 Nov 01; 100(9):3240-4. PMID: 12384423.
      View in: PubMed
    59. Camerer E, Kataoka H, Kahn M, Lease K, Coughlin S. Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. J Biol Chem. 2002 May 03; 277(18):16081-7. PMID: 11850418.
      View in: PubMed
    60. Coughlin S. Protease-activated receptors in the cardiovascular system. Cold Spring Harb Symp Quant Biol. 2002; 67:197-208. PMID: 12858541.
      View in: PubMed
    61. Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin S. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature. 2001 Sep 06; 413(6851):74-8. PMID: 11544528.
      View in: PubMed
    62. Griffin CT, Srinivasan Y, Zheng YW, Huang W, Coughlin S. A role for thrombin receptor signaling in endothelial cells during embryonic development. Science. 2001 Aug 31; 293(5535):1666-70. PMID: 11533492.
      View in: PubMed
    63. Coughlin S. Protease-activated receptors in vascular biology. Thromb Haemost. 2001 Jul; 86(1):298-307. PMID: 11487018.
      View in: PubMed
    64. Lindner JR, Kahn ML, Coughlin S, Sambrano GR, Schauble E, Bernstein D, Foy D, Hafezi-Moghadam A, Ley K. Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J Immunol. 2000 Dec 01; 165(11):6504-10. PMID: 11086091.
      View in: PubMed
    65. Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin S. Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. J Biol Chem. 2000 Oct 06; 275(40):31255-65. PMID: 10893235.
      View in: PubMed
    66. Coughlin S. Thrombin signalling and protease-activated receptors. Nature. 2000 Sep 14; 407(6801):258-64. PMID: 11001069.
      View in: PubMed
    67. Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin S, Craik CS. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. J Biol Chem. 2000 Aug 25; 275(34):26333-42. PMID: 10831593.
      View in: PubMed
    68. Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin S. Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. J Biol Chem. 2000 Aug 18; 275(33):25216-21. PMID: 10837487.
      View in: PubMed
    69. Faruqi TR, Weiss EJ, Shapiro MJ, Huang W, Coughlin S. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function. J Biol Chem. 2000 Jun 30; 275(26):19728-34. PMID: 10779527.
      View in: PubMed
    70. Camerer E, Huang W, Coughlin S. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5255-60. PMID: 10805786; PMCID: PMC25815.
    71. Shepherd FA, Dancey J, Ramlau R, Mattson K, Gralla R, O'Rourke M, Levitan N, Gressot L, Vincent M, Burkes R, Coughlin S, Kim Y, Berille J. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol. 2000 May; 18(10):2095-103. PMID: 10811675.
      View in: PubMed
    72. Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin S. PAR3 is a cofactor for PAR4 activation by thrombin. Nature. 2000 Apr 06; 404(6778):609-13. PMID: 10766244.
      View in: PubMed
    73. Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin S. Cathepsin G activates protease-activated receptor-4 in human platelets. J Biol Chem. 2000 Mar 10; 275(10):6819-23. PMID: 10702240.
      View in: PubMed
    74. Cunningham MA, Rondeau E, Chen X, Coughlin S, Holdsworth SR, Tipping PG. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med. 2000 Feb 07; 191(3):455-62. PMID: 10662791; PMCID: PMC2195821.
    75. Kahn ML, Diacovo TG, Bainton DF, Lanza F, Trejo J, Coughlin S. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Blood. 1999 Dec 15; 94(12):4112-21. PMID: 10590056.
      View in: PubMed
    76. Coughlin S. How the protease thrombin talks to cells. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11023-7. PMID: 10500117; PMCID: PMC34235.
    77. Coughlin S. Protease-activated receptors and platelet function. Thromb Haemost. 1999 Aug; 82(2):353-6. PMID: 10605724.
      View in: PubMed
    78. Hammes SR, Shapiro MJ, Coughlin S. Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail. Biochemistry. 1999 Jul 20; 38(29):9308-16. PMID: 10413505.
      View in: PubMed
    79. Sambrano GR, Coughlin S. The carboxyl tail of protease-activated receptor-1 is required for chemotaxis. Correlation of signal termination and directional migration. J Biol Chem. 1999 Jul 16; 274(29):20178-84. PMID: 10400633.
      View in: PubMed
    80. Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin S. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar; 103(6):879-87. PMID: 10079109; PMCID: PMC408153.
    81. Hammes SR, Coughlin S. Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand. Biochemistry. 1999 Feb 23; 38(8):2486-93. PMID: 10029543.
      View in: PubMed
    82. Trejo J, Coughlin S. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem. 1999 Jan 22; 274(4):2216-24. PMID: 9890984.
      View in: PubMed
    83. Trejo J, Hammes SR, Coughlin S. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13698-702. PMID: 9811863; PMCID: PMC24882.
    84. Shapiro MJ, Coughlin S. Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1. J Biol Chem. 1998 Oct 30; 273(44):29009-14. PMID: 9786906.
      View in: PubMed
    85. Kahn ML, Hammes SR, Botka C, Coughlin S. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. J Biol Chem. 1998 Sep 04; 273(36):23290-6. PMID: 9722561.
      View in: PubMed
    86. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin S. A dual thrombin receptor system for platelet activation. Nature. 1998 Aug 13; 394(6694):690-4. PMID: 9716134.
      View in: PubMed
    87. Ishihara H, Zeng D, Connolly AJ, Tam C, Coughlin S. Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Blood. 1998 Jun 01; 91(11):4152-7. PMID: 9596661.
      View in: PubMed
    88. Coughlin S. Sol Sherry lecture in thrombosis: how thrombin 'talks' to cells: molecular mechanisms and roles in vivo. Arterioscler Thromb Vasc Biol. 1998 Apr; 18(4):514-8. PMID: 9555855.
      View in: PubMed
    89. Bernstein HS, Coughlin S. A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry. J Biol Chem. 1998 Feb 20; 273(8):4666-71. PMID: 9468527.
      View in: PubMed
    90. An S, Bleu T, Huang W, Hallmark OG, Coughlin S, Goetzl EJ. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett. 1997 Nov 17; 417(3):279-82. PMID: 9409733.
      View in: PubMed
    91. Connolly AJ, Suh DY, Hunt TK, Coughlin S. Mice lacking the thrombin receptor, PAR1, have normal skin wound healing. Am J Pathol. 1997 Nov; 151(5):1199-204. PMID: 9358744; PMCID: PMC1858088.
    92. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin S. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 1997 Apr 03; 386(6624):502-6. PMID: 9087410.
      View in: PubMed
    93. Verrall S, Ishii M, Chen M, Wang L, Tram T, Coughlin S. The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors. J Biol Chem. 1997 Mar 14; 272(11):6898-902. PMID: 9054376.
      View in: PubMed
    94. Bernstein HS, Coughlin S. Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. J Biol Chem. 1997 Feb 28; 272(9):5833-7. PMID: 9038199.
      View in: PubMed
    95. Molino M, Bainton DF, Hoxie JA, Coughlin S, Brass LF. Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation. J Biol Chem. 1997 Feb 28; 272(9):6011-7. PMID: 9038223.
      View in: PubMed
    96. Shapiro MJ, Trejo J, Zeng D, Coughlin S. Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. J Biol Chem. 1996 Dec 20; 271(51):32874-80. PMID: 8955127.
      View in: PubMed
    97. Franci C, Gosling J, Tsou CL, Coughlin S, Charo IF. Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. J Immunol. 1996 Dec 15; 157(12):5606-12. PMID: 8955213.
      View in: PubMed
    98. Trejo J, Connolly AJ, Coughlin S. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem. 1996 Aug 30; 271(35):21536-41. PMID: 8702939.
      View in: PubMed
    99. Kranzhöfer R, Clinton SK, Ishii K, Coughlin S, Fenton JW, Libby P. Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes. Circ Res. 1996 Aug; 79(2):286-94. PMID: 8756006.
      View in: PubMed
    100. Lerner DJ, Chen M, Tram T, Coughlin S. Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function. J Biol Chem. 1996 Jun 14; 271(24):13943-7. PMID: 8662993.
      View in: PubMed
    101. Connolly AJ, Ishihara H, Kahn ML, Farese RV, Coughlin S. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 1996 Jun 06; 381(6582):516-9. PMID: 8632823.
      View in: PubMed
    102. Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol. 1996 May 01; 6(5):598-605. PMID: 8805275.
      View in: PubMed
    103. Kahn M, Ishii K, Kuo WL, Piper M, Connolly A, Shi YP, Wu R, Lin CC, Coughlin S. Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster. Mol Med. 1996 May; 2(3):349-57. PMID: 8784787; PMCID: PMC2230143.
    104. Bohm SK, Kong W, Bromme D, Smeekens SP, Anderson DC, Connolly A, Kahn M, Nelken NA, Coughlin S, Payan DG, Bunnett NW. Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem J. 1996 Mar 15; 314 ( Pt 3):1009-16. PMID: 8615752; PMCID: PMC1217107.
    105. Nanevicz T, Wang L, Chen M, Ishii M, Coughlin S. Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling. J Biol Chem. 1996 Jan 12; 271(2):702-6. PMID: 8557676.
      View in: PubMed
    106. Chen J, Bernstein HS, Chen M, Wang L, Ishii M, Turck CW, Coughlin S. Tethered ligand library for discovery of peptide agonists. J Biol Chem. 1995 Oct 06; 270(40):23398-401. PMID: 7559498.
      View in: PubMed
    107. Nanevicz T, Ishii M, Wang L, Chen M, Chen J, Turck CW, Cohen FE, Coughlin S. Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site. J Biol Chem. 1995 Sep 15; 270(37):21619-25. PMID: 7665575.
      View in: PubMed
    108. Ishii K, Gerszten R, Zheng YW, Welsh JB, Turck CW, Coughlin S. Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate. J Biol Chem. 1995 Jul 07; 270(27):16435-40. PMID: 7608215.
      View in: PubMed
    109. Hein L, Ishii K, Coughlin S, Kobilka BK. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. J Biol Chem. 1994 Nov 04; 269(44):27719-26. PMID: 7961693.
      View in: PubMed
    110. Coughlin S. Molecular mechanisms of thrombin signaling. Semin Hematol. 1994 Oct; 31(4):270-7. PMID: 7831572.
      View in: PubMed
    111. Coughlin S. Protease-activated receptors start a family. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9200-2. PMID: 7937741; PMCID: PMC44779.
    112. Chen J, Ishii M, Wang L, Ishii K, Coughlin S. Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode. J Biol Chem. 1994 Jun 10; 269(23):16041-5. PMID: 8206902.
      View in: PubMed
    113. Gerszten RE, Chen J, Ishii M, Ishii K, Wang L, Nanevicz T, Turck CW, Vu TK, Coughlin S. Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface. Nature. 1994 Apr 14; 368(6472):648-51. PMID: 8145852.
      View in: PubMed
    114. Coughlin S. Expanding horizons for receptors coupled to G proteins: diversity and disease. Curr Opin Cell Biol. 1994 Apr; 6(2):191-7. PMID: 8024809.
      View in: PubMed
    115. Charo IF, Myers SJ, Herman A, Franci C, Connolly AJ, Coughlin S. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2752-6. PMID: 8146186; PMCID: PMC43448.
    116. Mathews II, Padmanabhan KP, Ganesh V, Tulinsky A, Ishii M, Chen J, Turck CW, Coughlin S, Fenton JW. Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes. Biochemistry. 1994 Mar 22; 33(11):3266-79. PMID: 8136362.
      View in: PubMed
    117. Coughlin S. Thrombin receptor function and cardiovascular disease. Trends Cardiovasc Med. 1994 Mar-Apr; 4(2):77-83. PMID: 21244899.
      View in: PubMed
    118. Ishii K, Chen J, Ishii M, Koch WJ, Freedman NJ, Lefkowitz RJ, Coughlin S. Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. J Biol Chem. 1994 Jan 14; 269(2):1125-30. PMID: 8288570.
      View in: PubMed
    119. Soifer SJ, Peters KG, O'Keefe J, Coughlin S. Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development. Am J Pathol. 1994 Jan; 144(1):60-9. PMID: 8291612; PMCID: PMC1887128.
    120. Coughlin S. Thrombin receptor structure and function. Thromb Haemost. 1993 Jul 01; 70(1):184-7. PMID: 8236100.
      View in: PubMed
    121. Ishii K, Hein L, Kobilka B, Coughlin S. Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling. J Biol Chem. 1993 May 05; 268(13):9780-6. PMID: 7683662.
      View in: PubMed
    122. McNamara CA, Sarembock IJ, Gimple LW, Fenton JW, Coughlin S, Owens GK. Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest. 1993 Jan; 91(1):94-8. PMID: 8380817; PMCID: PMC330000.
    123. Hung DT, Wong YH, Vu TK, Coughlin S. The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase. J Biol Chem. 1992 Oct 15; 267(29):20831-4. PMID: 1328213.
      View in: PubMed
    124. Nelken NA, Soifer SJ, O'Keefe J, Vu TK, Charo IF, Coughlin S. Thrombin receptor expression in normal and atherosclerotic human arteries. J Clin Invest. 1992 Oct; 90(4):1614-21. PMID: 1328304; PMCID: PMC443210.
    125. Scarborough RM, Naughton MA, Teng W, Hung DT, Rose J, Vu TK, Wheaton VI, Turck CW, Coughlin S. Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function. J Biol Chem. 1992 Jul 05; 267(19):13146-9. PMID: 1320011.
      View in: PubMed
    126. Hung DT, Vu TK, Wheaton VI, Ishii K, Coughlin S. Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation. J Clin Invest. 1992 Apr; 89(4):1350-3. PMID: 1313452; PMCID: PMC442997.
    127. Coughlin S, Vu TK, Hung DT, Wheaton VI. Characterization of a functional thrombin receptor. Issues and opportunities. J Clin Invest. 1992 Feb; 89(2):351-5. PMID: 1310691; PMCID: PMC442859.
    128. Hung DT, Vu TK, Wheaton VI, Charo IF, Nelken NA, Esmon N, Esmon CT, Coughlin S. "Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure. J Clin Invest. 1992 Feb; 89(2):444-50. PMID: 1310695; PMCID: PMC442871.
    129. Hung DT, Vu TH, Nelken NA, Coughlin S. Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor. J Cell Biol. 1992 Feb; 116(3):827-32. PMID: 1309820; PMCID: PMC2289317.
    130. Coughlin S, Scarborough RM, Vu TK, Hung DT. Thrombin receptor structure and function. Cold Spring Harb Symp Quant Biol. 1992; 57:149-54. PMID: 1339654.
      View in: PubMed
    131. Coughlin S, Vu TK, Hung DT, Wheaton VI. Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Semin Thromb Hemost. 1992; 18(2):161-6. PMID: 1321504.
      View in: PubMed
    132. Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin S. Domains specifying thrombin-receptor interaction. Nature. 1991 Oct 17; 353(6345):674-7. PMID: 1717851.
      View in: PubMed
    133. Nelken NA, Coughlin S, Gordon D, Wilcox JN. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest. 1991 Oct; 88(4):1121-7. PMID: 1843454; PMCID: PMC295565.
    134. Liu LW, Vu TK, Esmon CT, Coughlin S. The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem. 1991 Sep 15; 266(26):16977-80. PMID: 1654318.
      View in: PubMed
    135. Lanza F, Wolf D, Fox CF, Kieffer N, Seyer JM, Fried VA, Coughlin S, Phillips DR, Jennings LK. cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins. J Biol Chem. 1991 Jun 05; 266(16):10638-45. PMID: 2037603.
      View in: PubMed
    136. Vu TK, Hung DT, Wheaton VI, Coughlin S. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991 Mar 22; 64(6):1057-68. PMID: 1672265.
      View in: PubMed
    137. Coughlin S, Escobedo JA, Williams LT. Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science. 1989 Mar 03; 243(4895):1191-4. PMID: 2466336.
      View in: PubMed
    138. Kavanaugh WM, Williams LT, Ives HE, Coughlin S. Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway. Mol Endocrinol. 1988 Jul; 2(7):599-605. PMID: 2842665.
      View in: PubMed
    139. Escobedo JA, Navankasatussas S, Cousens LS, Coughlin S, Bell GI, Williams LT. A common PDGF receptor is activated by homodimeric A and B forms of PDGF. Science. 1988 Jun 10; 240(4858):1532-4. PMID: 2836953.
      View in: PubMed
    140. Coughlin S, Barr PJ, Cousens LS, Fretto LJ, Williams LT. Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo. J Biol Chem. 1988 Jan 15; 263(2):988-93. PMID: 2447083.
      View in: PubMed
    141. Coughlin S, Escobedo JA, Williams LT. Molecular mechanisms of platelet-derived growth factor action. Prog Clin Biol Res. 1988; 266:39-45. PMID: 2837788.
      View in: PubMed
    142. Williams LT, Escobedo JA, Keating MT, Coughlin S. Signal transduction by the platelet-derived growth factor receptor. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:455-65. PMID: 2855486.
      View in: PubMed
    143. Kacich RL, Williams LT, Coughlin S. Arachidonic acid and cyclic adenosine monophosphate stimulation of c-fos expression by a pathway independent of phorbol ester-sensitive protein kinase C. Mol Endocrinol. 1988 Jan; 2(1):73-7. PMID: 2840568.
      View in: PubMed
    144. Williams LT, Escobedo JA, Keating MT, Coughlin S. The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor. J Cell Physiol Suppl. 1987; Suppl 5:27-30. PMID: 2824531.
      View in: PubMed
    145. Starksen NF, Simpson PC, Bishopric N, Coughlin S, Lee WM, Escobedo JA, Williams LT. Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8348-50. PMID: 3022291; PMCID: PMC386925.
    146. Simpson P, Bishopric N, Coughlin S, Karliner J, Ordahl C, Starksen N, Tsao T, White N, Williams L. Dual trophic effects of the alpha 1-adrenergic receptor in cultured neonatal rat heart muscle cells. J Mol Cell Cardiol. 1986 Nov; 18 Suppl 5:45-58. PMID: 3027351.
      View in: PubMed
    147. Coughlin S, Lee WM, Williams PW, Giels GM, Williams LT. c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF. Cell. 1985 Nov; 43(1):243-51. PMID: 3000601.
      View in: PubMed
    148. Coughlin S, Moskowitz MA, Zetter BR, Antoniades HN, Levine L. Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor. Nature. 1980 Dec 11; 288(5791):600-2. PMID: 7003399.
      View in: PubMed
    Shaun's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _
    Back to TOP