Shaun Coughlin, MD, PhD

Title(s)Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-502-8667
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    Other Positions
    Title(s)Director, Cardiovascular Research Institute


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1986School of Medicine
    University of California, San Francisco Residency School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Structure-Function and Roles of Protease-Activated Receptors
    NIH R35HL135755Feb 14, 2017 - Oct 31, 2017
    Role: Principal Investigator
    Structural Basis of Protease-Activated Receptor Function
    NIH R01HL121387Jan 15, 2014 - Dec 31, 2017
    Role: Principal Investigator
    PARs and S1P receptors in endothelial biology
    NIH R01HL065590Sep 30, 2000 - Mar 31, 2015
    Role: Principal Investigator
    Thrombin signaling in Hemostatis and thrombosis
    NIH R01HL065185Sep 5, 2000 - Nov 30, 2012
    Role: Principal Investigator
    Protease-activated receptors in inflammation
    NIH R01HL059202Jan 1, 1998 - Mar 31, 2008
    Role: Principal Investigator
    Molecular Genetics of Cardiac Cell Differentiation
    NIH R01HL054737Apr 1, 1996 - Dec 31, 2016
    Role: Principal Investigator
    MURINE MODELS TO INVESTIGATE THE HEMATOLOGIC SYSTEM
    NIH P01DK050267Aug 15, 1995 - Jul 31, 2001
    Role: Co-Principal Investigator
    GORDON CONFERENCE--ATHEROSCLEROSIS 1993
    NIH R13HL050524Aug 1, 1993 - Jul 31, 1994
    Role: Principal Investigator
    Molecular and Cellular Basis of Cardiovascular Disease
    NIH T32HL007731Jul 1, 1992 - May 31, 2023
    Role: Principal Investigator
    Molecular Mechanisms of Protease Signaling
    NIH R01HL044907Apr 1, 1991 - Mar 31, 2010
    Role: Principal Investigator
    CELL AND MOLECULES MEDIATING GRAFT ATHEROSCLEROSIS
    NIH R01HL043322Jul 1, 1989 - Apr 30, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microglial Gi-dependent dynamics regulate brain network hyperexcitability. Nat Neurosci. 2021 01; 24(1):19-23. Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T, Acevedo RM, Cabriga B, Thomas R, Coughlin SR, Ellisman MH, Palop JJ, Akassoglou K. PMID: 33318667.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    2. Protease-Activated Receptor-2 Regulates Neuro-Epidermal Communication in Atopic Dermatitis. Front Immunol. 2020; 11:1740. Buhl T, Ikoma A, Kempkes C, Cevikbas F, Sulk M, Buddenkotte J, Akiyama T, Crumrine D, Camerer E, Carstens E, Schön MP, Elias P, Coughlin SR, Steinhoff M. PMID: 32903402.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    3. Designing a Green Fluorogenic Protease Reporter by Flipping a Beta Strand of GFP for Imaging Apoptosis in Animals. J Am Chem Soc. 2019 03 20; 141(11):4526-4530. Zhang Q, Schepis A, Huang H, Yang J, Ma W, Torra J, Zhang SQ, Yang L, Wu H, Nonell S, Dong Z, Kornberg TB, Coughlin SR, Shu X. PMID: 30821975.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    4. Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 10 02; 57(39):5748-5758. Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. PMID: 30102523.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish. Dev Cell. 2018 07 02; 46(1):112-125.e4. Wu RS, Lam II, Clay H, Duong DN, Deo RC, Coughlin SR. PMID: 29974860.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    6. A rapid fluorogenic GPCR-β-arrestin interaction assay. Protein Sci. 2018 04; 27(4):874-879. Zhang Q, Zheng YW, Coughlin SR, Shu X. PMID: 29411438.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    7. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 01 18; 69(2):347. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. PMID: 29351851.
      View in: PubMed   Mentions: 5     Fields:    
    8. Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Sci Signal. 2018 01 16; 11(513). Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A. PMID: 29339534.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent. Structure. 2018 02 06; 26(2):187-198.e4. Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL, Coughlin SR. PMID: 29336885.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 01 18; 69(2):334-346.e4. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. PMID: 29307513.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    11. Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. J Cell Biol. 2018 03 05; 217(3):1097-1112. Schepis A, Barker A, Srinivasan Y, Balouch E, Zheng Y, Lam I, Clay H, Hsiao CD, Coughlin SR. PMID: 29301867.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    12. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. PMID: 28329764.
      View in: PubMed   Mentions: 234     Fields:    Translation:AnimalsCells
    13. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circ Res. 2016 Sep 30; 119(8):e110-26. Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E. PMID: 27582371.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    14. Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis. Sci Transl Med. 2016 08 24; 8(353):353ra112. David T, Kim YC, Ely LK, Rondon I, Gao H, O'Brien P, Bolt MW, Coyle AJ, Garcia JL, Flounders EA, Mikita T, Coughlin SR. PMID: 27559095.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    15. Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis In Vivo. Cell Chem Biol. 2016 07 21; 23(7):875-882. To TL, Schepis A, Ruiz-González R, Zhang Q, Yu D, Dong Z, Coughlin SR, Shu X. PMID: 27447051.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    16. Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development. Dev Biol. 2016 10 01; 418(1):157-165. Clay H, Wilsbacher LD, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin SR. PMID: 27333774.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    17. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016 Apr 12; 7:11303. Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DYR, Gollob MH. PMID: 27066836.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    18. Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM. Nat Commun. 2015 Nov 12; 6:8857. Pfreundschuh M, Alsteens D, Wieneke R, Zhang C, Coughlin SR, Tampé R, Kobilka BK, Müller DJ. PMID: 26561004.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    19. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015 Oct 16; 4:e09406. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. PMID: 26473617.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    20. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nat Commun. 2015 Oct 01; 6:8448. Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS. PMID: 26423607.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. 2015 Oct 22; 126(17):2047-58. Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin SR, Degen JL, Flick MJ. PMID: 26228483.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    22. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape. Nat Methods. 2015 Sep; 12(9):845-851. Alsteens D, Pfreundschuh M, Zhang C, Spoerri PM, Coughlin SR, Kobilka BK, Müller DJ. PMID: 26167642.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    23. Analysis of cardiomyocyte development using immunofluorescence in embryonic mouse heart. J Vis Exp. 2015 Mar 26; (97). Wilsbacher LD, Coughlin SR. PMID: 25866997.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    24. Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2888-93. Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS. PMID: 25695968.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    25. Mechanical vessel injury in zebrafish embryos. J Vis Exp. 2015 Feb 17; (96):e52460. Clay H, Coughlin SR. PMID: 25742284.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    26. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 2014 Nov 27; 124(23):3450-8. Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. PMID: 25293779.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    27. Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2563-9. Bynagari-Settipalli YS, Cornelissen I, Palmer D, Duong D, Concengco C, Ware J, Coughlin SR. PMID: 25278288.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    28. The imperative to invest in science has never been greater. J Clin Invest. 2014 Sep; 124(9):3680-1. Carethers JM, Coughlin S, Diamond B, Erzurum S, Fried LP, Jameson JL, Kaushansky K, Klotman ME, Lemon S, Mitchell B, Rothman P, Sawyers C, Seidman C, Somlo S. PMID: 25180532.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    29. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 03; 502(7469):105-9. Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L. PMID: 23995678.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    30. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. PMID: 23657000.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    31. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012 Dec 20; 492(7429):387-92. Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. PMID: 23222541.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansCells
    32. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest. 2013 Jan; 123(1):206-14. Khoufache K, Berri F, Nacken W, Vogel AB, Delenne M, Camerer E, Coughlin SR, Carmeliet P, Lina B, Rimmelzwaan GF, Planz O, Ludwig S, Riteau B. PMID: 23202729.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    33. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell. 2012 Sep 28; 151(1):111-22. Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY. PMID: 23021219.
      View in: PubMed   Mentions: 173     Fields:    Translation:AnimalsCells
    34. Wnt/β-catenin signaling is differentially regulated by Gα proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20101-6. Regard JB, Cherman N, Palmer D, Kuznetsov SA, Celi FS, Guettier JM, Chen M, Bhattacharyya N, Wess J, Coughlin SR, Weinstein LS, Collins MT, Robey PG, Yang Y. PMID: 22106277.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    35. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science. 2011 Sep 30; 333(6051):1898-903. Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. PMID: 21960637.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    36. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood. 2011 Oct 13; 118(15):4015-23. Shao B, Wahrenbrock MG, Yao L, David T, Coughlin SR, Xia L, Varki A, McEver RP. PMID: 21860019.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    37. The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011 Jun 05; 12(7):672-80. Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG. PMID: 21642988.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    38. PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nat Commun. 2011 Jan 18; 2:161. Frateschi S, Camerer E, Crisante G, Rieser S, Membrez M, Charles RP, Beermann F, Stehle JC, Breiden B, Sandhoff K, Rotman S, Haftek M, Wilson A, Ryser S, Steinhoff M, Coughlin SR, Hummler E. PMID: 21245842.
      View in: PubMed   Mentions: 37     Fields:    
    39. Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18605-10. Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin SR. PMID: 20930120.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    40. Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group. Circulation. 2010 Mar 30; 121(12):1447-54. Eagle KA, Ginsburg GS, Musunuru K, Aird WC, Balaban RS, Bennett SK, Blumenthal RS, Coughlin SR, Davidson KW, Frohlich ED, Greenland P, Jarvik GP, Libby P, Pepine CJ, Ruskin JN, Stillman AE, Van Eyk JE, Tolunay HE, McDonald CL, Smith SC. PMID: 20351302.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    41. Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010 Jan 19; 18(1):25-38. Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, Kirchhofer D, Coughlin SR. PMID: 20152175.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    42. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med. 2010 Jan 18; 207(1):17-27. Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin SR, McDonald DM, Schwab SR, Cyster JG. PMID: 20026661.
      View in: PubMed   Mentions: 199     Fields:    Translation:AnimalsCells
    43. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest. 2009 Jul; 119(7):1871-9. Camerer E, Regard JB, Cornelissen I, Srinivasan Y, Duong DN, Palmer D, Pham TH, Wong JS, Pappu R, Coughlin SR. PMID: 19603543.
      View in: PubMed   Mentions: 165     Fields:    Translation:Animals
    44. Atherosclerosis proceeds independently of thrombin-induced platelet activation in ApoE-/- mice. Atherosclerosis. 2009 Aug; 205(2):427-32. Hamilton JR, Cornelissen I, Mountford JK, Coughlin SR. PMID: 19217621.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    45. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development. 2009 Jan; 136(2):327-35. Li G, Kataoka H, Coughlin SR, Pleasure SJ. PMID: 19103804.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    46. Anatomical profiling of G protein-coupled receptor expression. Cell. 2008 Oct 31; 135(3):561-71. Regard JB, Sato IT, Coughlin SR. PMID: 18984166.
      View in: PubMed   Mentions: 235     Fields:    Translation:AnimalsCells
    47. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol. 2008 Jun 30; 181(7):1211-22. Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. PMID: 18573917.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    48. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. Blood. 2008 Aug 01; 112(3):585-91. Sood R, Sholl L, Isermann B, Zogg M, Coughlin SR, Weiler H. PMID: 18490515.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    49. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest. 2008 Mar; 118(3):1123-31. Cho J, Furie BC, Coughlin SR, Furie B. PMID: 18292814.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    50. Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest. 2007 Dec; 117(12):4034-43. Regard JB, Kataoka H, Cano DA, Camerer E, Yin L, Zheng YW, Scanlan TS, Hebrok M, Coughlin SR. PMID: 17992256.
      View in: PubMed   Mentions: 105     Fields:    Translation:AnimalsCells
    51. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. J Exp Med. 2007 May 14; 204(5):1049-56. Sood R, Zogg M, Westrick RJ, Guo YH, Kerschen EJ, Girardi G, Salmon JE, Coughlin SR, Weiler H. PMID: 17438064.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    52. Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology. 2007 Jun; 132(7):2422-37. Cottrell GS, Amadesi S, Pikios S, Camerer E, Willardsen JA, Murphy BR, Caughey GH, Wolters PJ, Coughlin SR, Peterson A, Knecht W, Pothoulakis C, Bunnett NW, Grady EF. PMID: 17570216.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    53. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science. 2007 Apr 13; 316(5822):295-8. Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, Coughlin SR. PMID: 17363629.
      View in: PubMed   Mentions: 384     Fields:    Translation:AnimalsCells
    54. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):288-92. Vandendries ER, Hamilton JR, Coughlin SR, Furie B, Furie BC. PMID: 17190826.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    55. Defective platelet responsiveness to thrombin and protease-activated receptors agonists in a novel case of gray platelet syndrome: correlation between the platelet defect and the alpha-granule content in the patient and four relatives. J Thromb Haemost. 2007 Mar; 5(3):551-9. De Candia E, Pecci A, Ciabattoni G, De Cristofaro R, Rutella S, Yao-Wu Z, Lazzareschi I, Landolfi R, Coughlin S, Balduini CL. PMID: 17137471.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    56. Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site. J Virol. 2006 Dec; 80(23):11510-9. Yuan J, Stein DA, Lim T, Qiu D, Coughlin S, Liu Z, Wang Y, Blouch R, Moulton HM, Iversen PL, Yang D. PMID: 16987987.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    57. Roles of protease-activated receptors in a mouse model of endotoxemia. Blood. 2006 May 15; 107(10):3912-21. Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin SR. PMID: 16434493.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    58. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005 Aug 15; 175(4):2598-605. Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA. PMID: 16081834.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    59. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost. 2005 Aug; 3(8):1800-14. Coughlin SR. PMID: 16102047.
      View in: PubMed   Mentions: 328     Fields:    Translation:HumansAnimalsCells
    60. Essential role for Galpha13 in endothelial cells during embryonic development. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8281-6. Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR. PMID: 15919816.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    61. PAR1 cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 2005 Apr 01; 280(13):13122-8. Ludeman MJ, Kataoka H, Srinivasan Y, Esmon NL, Esmon CT, Coughlin SR. PMID: 15665002.
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    62. Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets. J Thromb Haemost. 2004 Aug; 2(8):1429-35. Hamilton JR, Cornelissen I, Coughlin SR. PMID: 15304051.
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    63. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood. 2004 Jul 15; 104(2):397-401. Camerer E, Qazi AA, Duong DN, Cornelissen I, Advincula R, Coughlin SR. PMID: 15031212.
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    64. Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. J Biol Chem. 2004 Apr 30; 279(18):18592-9. Ludeman MJ, Zheng YW, Ishii K, Coughlin SR. PMID: 14982936.
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    65. Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency. Blood. 2004 Jan 01; 103(1):152-4. Camerer E, Duong DN, Hamilton JR, Coughlin SR. PMID: 14504091.
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    67. The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. J Biol Chem. 2003 Aug 15; 278(33):30975-84. Eisenhaure TM, Francis SA, Willison LD, Coughlin SR, Lerner DJ. PMID: 12773540.
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    68. PARticipation in inflammation. J Clin Invest. 2003 Jan; 111(1):25-7. Coughlin SR, Camerer E. PMID: 12511583.
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    69. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR, Participating investigators and scientists of the Alliance for Cellular Signaling . PMID: 12478301.
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    70. Protection against thrombosis in mice lacking PAR3. Blood. 2002 Nov 01; 100(9):3240-4. Weiss EJ, Hamilton JR, Lease KE, Coughlin SR. PMID: 12384423.
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    71. Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. J Biol Chem. 2002 May 03; 277(18):16081-7. Camerer E, Kataoka H, Kahn M, Lease K, Coughlin SR. PMID: 11850418.
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    72. Protease-activated receptors in the cardiovascular system. Cold Spring Harb Symp Quant Biol. 2002; 67:197-208. Coughlin SR. PMID: 12858541.
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    73. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature. 2001 Sep 06; 413(6851):74-8. Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR. PMID: 11544528.
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    75. Protease-activated receptors in vascular biology. Thromb Haemost. 2001 Jul; 86(1):298-307. Coughlin SR. PMID: 11487018.
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    76. Delayed onset of inflammation in protease-activated receptor-2-deficient mice. J Immunol. 2000 Dec 01; 165(11):6504-10. Lindner JR, Kahn ML, Coughlin SR, Sambrano GR, Schauble E, Bernstein D, Foy D, Hafezi-Moghadam A, Ley K. PMID: 11086091.
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    77. Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits. J Biol Chem. 2000 Oct 06; 275(40):31255-65. Trejo J, Altschuler Y, Fu HW, Mostov KE, Coughlin SR. PMID: 10893235.
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    78. Thrombin signalling and protease-activated receptors. Nature. 2000 Sep 14; 407(6801):258-64. Coughlin SR. PMID: 11001069.
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    79. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. J Biol Chem. 2000 Aug 25; 275(34):26333-42. Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS. PMID: 10831593.
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    80. Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. J Biol Chem. 2000 Aug 18; 275(33):25216-21. Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin SR. PMID: 10837487.
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    81. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function. J Biol Chem. 2000 Jun 30; 275(26):19728-34. Faruqi TR, Weiss EJ, Shapiro MJ, Huang W, Coughlin SR. PMID: 10779527.
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    82. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5255-60. Camerer E, Huang W, Coughlin SR. PMID: 10805786.
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    83. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol. 2000 May; 18(10):2095-103. Shepherd FA, Dancey J, Ramlau R, Mattson K, Gralla R, O'Rourke M, Levitan N, Gressot L, Vincent M, Burkes R, Coughlin S, Kim Y, Berille J. PMID: 10811675.
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    84. PAR3 is a cofactor for PAR4 activation by thrombin. Nature. 2000 Apr 06; 404(6778):609-13. Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR. PMID: 10766244.
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    85. Cathepsin G activates protease-activated receptor-4 in human platelets. J Biol Chem. 2000 Mar 10; 275(10):6819-23. Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR. PMID: 10702240.
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    86. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med. 2000 Feb 07; 191(3):455-62. Cunningham MA, Rondeau E, Chen X, Coughlin SR, Holdsworth SR, Tipping PG. PMID: 10662791.
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    87. Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype. Blood. 1999 Dec 15; 94(12):4112-21. Kahn ML, Diacovo TG, Bainton DF, Lanza F, Trejo J, Coughlin SR. PMID: 10590056.
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    88. How the protease thrombin talks to cells. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11023-7. Coughlin SR. PMID: 10500117.
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    89. Protease-activated receptors and platelet function. Thromb Haemost. 1999 Aug; 82(2):353-6. Coughlin SR. PMID: 10605724.
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    90. Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail. Biochemistry. 1999 Jul 20; 38(29):9308-16. Hammes SR, Shapiro MJ, Coughlin SR. PMID: 10413505.
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    91. The carboxyl tail of protease-activated receptor-1 is required for chemotaxis. Correlation of signal termination and directional migration. J Biol Chem. 1999 Jul 16; 274(29):20178-84. Sambrano GR, Coughlin SR. PMID: 10400633.
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    92. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar; 103(6):879-87. Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. PMID: 10079109.
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    93. Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand. Biochemistry. 1999 Feb 23; 38(8):2486-93. Hammes SR, Coughlin SR. PMID: 10029543.
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    94. The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling. J Biol Chem. 1999 Jan 22; 274(4):2216-24. Trejo J, Coughlin SR. PMID: 9890984.
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    95. Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13698-702. Trejo J, Hammes SR, Coughlin SR. PMID: 9811863.
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    96. Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1. J Biol Chem. 1998 Oct 30; 273(44):29009-14. Shapiro MJ, Coughlin SR. PMID: 9786906.
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    97. Gene and locus structure and chromosomal localization of the protease-activated receptor gene family. J Biol Chem. 1998 Sep 04; 273(36):23290-6. Kahn ML, Hammes SR, Botka C, Coughlin SR. PMID: 9722561.
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    98. A dual thrombin receptor system for platelet activation. Nature. 1998 Aug 13; 394(6694):690-4. Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin SR. PMID: 9716134.
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    99. Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Blood. 1998 Jun 01; 91(11):4152-7. Ishihara H, Zeng D, Connolly AJ, Tam C, Coughlin SR. PMID: 9596661.
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    100. Sol Sherry lecture in thrombosis: how thrombin 'talks' to cells: molecular mechanisms and roles in vivo. Arterioscler Thromb Vasc Biol. 1998 Apr; 18(4):514-8. Coughlin SR. PMID: 9555855.
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    101. A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry. J Biol Chem. 1998 Feb 20; 273(8):4666-71. Bernstein HS, Coughlin SR. PMID: 9468527.
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    102. Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett. 1997 Nov 17; 417(3):279-82. An S, Bleu T, Huang W, Hallmark OG, Coughlin SR, Goetzl EJ. PMID: 9409733.
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    103. Mice lacking the thrombin receptor, PAR1, have normal skin wound healing. Am J Pathol. 1997 Nov; 151(5):1199-204. Connolly AJ, Suh DY, Hunt TK, Coughlin SR. PMID: 9358744.
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    104. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 1997 Apr 03; 386(6624):502-6. Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR. PMID: 9087410.
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    105. The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors. J Biol Chem. 1997 Mar 14; 272(11):6898-902. Verrall S, Ishii M, Chen M, Wang L, Tram T, Coughlin SR. PMID: 9054376.
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    106. Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. J Biol Chem. 1997 Feb 28; 272(9):5833-7. Bernstein HS, Coughlin SR. PMID: 9038199.
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    107. Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation. J Biol Chem. 1997 Feb 28; 272(9):6011-7. Molino M, Bainton DF, Hoxie JA, Coughlin SR, Brass LF. PMID: 9038223.
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    108. Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization. J Biol Chem. 1996 Dec 20; 271(51):32874-80. Shapiro MJ, Trejo J, Zeng D, Coughlin SR. PMID: 8955127.
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    109. Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. J Immunol. 1996 Dec 15; 157(12):5606-12. Franci C, Gosling J, Tsou CL, Coughlin SR, Charo IF. PMID: 8955213.
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    110. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem. 1996 Aug 30; 271(35):21536-41. Trejo J, Connolly AJ, Coughlin SR. PMID: 8702939.
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    111. Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes. Circ Res. 1996 Aug; 79(2):286-94. Kranzhöfer R, Clinton SK, Ishii K, Coughlin SR, Fenton JW, Libby P. PMID: 8756006.
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    113. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 1996 Jun 06; 381(6582):516-9. Connolly AJ, Ishihara H, Kahn ML, Farese RV, Coughlin SR. PMID: 8632823.
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    114. Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster. Mol Med. 1996 May; 2(3):349-57. Kahn M, Ishii K, Kuo WL, Piper M, Connolly A, Shi YP, Wu R, Lin CC, Coughlin SR. PMID: 8784787.
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    115. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr Biol. 1996 May 01; 6(5):598-605. Brown JL, Stowers L, Baer M, Trejo J, Coughlin S, Chant J. PMID: 8805275.
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    121. Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor. J Biol Chem. 1994 Nov 04; 269(44):27719-26. Hein L, Ishii K, Coughlin SR, Kobilka BK. PMID: 7961693.
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    140. Characterization of a functional thrombin receptor. Issues and opportunities. J Clin Invest. 1992 Feb; 89(2):351-5. Coughlin SR, Vu TK, Hung DT, Wheaton VI. PMID: 1310691.
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    141. "Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure. J Clin Invest. 1992 Feb; 89(2):444-50. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Hung DT, Vu TK, Wheaton VI, Charo IF, Nelken NA, Esmon N, Esmon CT, Coughlin SR. PMID: 1310695; PMCID: PMC442871.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    142. Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Semin Thromb Hemost. 1992; 18(2):161-6. Coughlin SR, Vu TK, Hung DT, Wheaton VI. PMID: 1321504.
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    143. Thrombin receptor structure and function. Cold Spring Harb Symp Quant Biol. 1992; 57:149-54. Coughlin SR, Scarborough RM, Vu TK, Hung DT. PMID: 1339654.
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    144. Domains specifying thrombin-receptor interaction. Nature. 1991 Oct 17; 353(6345):674-7. Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR. PMID: 1717851.
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    145. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest. 1991 Oct; 88(4):1121-7. Nelken NA, Coughlin SR, Gordon D, Wilcox JN. PMID: 1843454.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansCells
    146. The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem. 1991 Sep 15; 266(26):16977-80. Liu LW, Vu TK, Esmon CT, Coughlin SR. PMID: 1654318.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansCells
    147. cDNA cloning and expression of platelet p24/CD9. Evidence for a new family of multiple membrane-spanning proteins. J Biol Chem. 1991 Jun 05; 266(16):10638-45. Lanza F, Wolf D, Fox CF, Kieffer N, Seyer JM, Fried VA, Coughlin SR, Phillips DR, Jennings LK. PMID: 2037603.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    148. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell. 1991 Mar 22; 64(6):1057-68. Vu TK, Hung DT, Wheaton VI, Coughlin SR. PMID: 1672265.
      View in: PubMed   Mentions: 604     Fields:    Translation:HumansAnimalsCells
    149. Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science. 1989 Mar 03; 243(4895):1191-4. Coughlin SR, Escobedo JA, Williams LT. PMID: 2466336.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    150. Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway. Mol Endocrinol. 1988 Jul; 2(7):599-605. Kavanaugh WM, Williams LT, Ives HE, Coughlin SR. PMID: 2842665.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    151. A common PDGF receptor is activated by homodimeric A and B forms of PDGF. Science. 1988 Jun 10; 240(4858):1532-4. Escobedo JA, Navankasatussas S, Cousens LS, Coughlin SR, Bell GI, Williams LT. PMID: 2836953.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    152. Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo. J Biol Chem. 1988 Jan 15; 263(2):988-93. Coughlin SR, Barr PJ, Cousens LS, Fretto LJ, Williams LT. PMID: 2447083.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    153. Molecular mechanisms of platelet-derived growth factor action. Prog Clin Biol Res. 1988; 266:39-45. Coughlin SR, Escobedo JA, Williams LT. PMID: 2837788.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    154. Arachidonic acid and cyclic adenosine monophosphate stimulation of c-fos expression by a pathway independent of phorbol ester-sensitive protein kinase C. Mol Endocrinol. 1988 Jan; 2(1):73-7. Kacich RL, Williams LT, Coughlin SR. PMID: 2840568.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    155. Signal transduction by the platelet-derived growth factor receptor. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:455-65. Williams LT, Escobedo JA, Keating MT, Coughlin SR. PMID: 2855486.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    156. The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor. J Cell Physiol Suppl. 1987; Suppl 5:27-30. Williams LT, Escobedo JA, Keating MT, Coughlin SR. PMID: 2824531.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    157. Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8348-50. Starksen NF, Simpson PC, Bishopric N, Coughlin SR, Lee WM, Escobedo JA, Williams LT. PMID: 3022291.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    158. Dual trophic effects of the alpha 1-adrenergic receptor in cultured neonatal rat heart muscle cells. J Mol Cell Cardiol. 1986 Nov; 18 Suppl 5:45-58. Simpson P, Bishopric N, Coughlin S, Karliner J, Ordahl C, Starksen N, Tsao T, White N, Williams L. PMID: 3027351.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    159. c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF. Cell. 1985 Nov; 43(1):243-51. Coughlin SR, Lee WM, Williams PW, Giels GM, Williams LT. PMID: 3000601.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    160. Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor. Nature. 1980 Dec 11; 288(5791):600-2. Coughlin SR, Moskowitz MA, Zetter BR, Antoniades HN, Levine L. PMID: 7003399.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
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