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Shaun Coughlin, MD, PhD

Title(s)Professor Emeritus, Cardiovascular Research Inst
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone415-502-8667
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    Other Positions
    Title(s)Director, Cardiovascular Research Institute


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1986School of Medicine
    University of California, San Francisco Residency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Structure-Function and Roles of Protease-Activated Receptors
    NIH/NHLBI R35HL135755Feb 14, 2017 - Dec 31, 2023
    Role: Principal Investigator
    Structural Basis of Protease-Activated Receptor Function
    NIH/NHLBI R01HL121387Jan 15, 2014 - Dec 31, 2017
    Role: Principal Investigator
    PARs and S1P receptors in endothelial biology
    NIH/NHLBI R01HL065590Sep 30, 2000 - May 31, 2014
    Role: Principal Investigator
    Thrombin signaling in Hemostatis and thrombosis
    NIH/NHLBI R01HL065185Sep 5, 2000 - Nov 30, 2012
    Role: Principal Investigator
    Protease-activated receptors in inflammation
    NIH/NHLBI R01HL059202Jan 1, 1998 - Nov 30, 2002
    Role: Principal Investigator
    MURINE MODELS TO INVESTIGATE THE HEMATOLOGIC SYSTEM
    NIH/NIDDK P01DK050267Aug 1, 1997 - Jul 31, 2001
    Role: Co-Principal Investigator
    Molecular Genetics of Cardiac Cell Differentiation
    NIH/NHLBI R01HL054737Apr 1, 1996 - May 31, 2001
    Role: Principal Investigator
    GORDON CONFERENCE--ATHEROSCLEROSIS 1993
    NIH/NHLBI R13HL050524Aug 1, 1993 - Jul 31, 1994
    Role: Principal Investigator
    Molecular and Cellular Basis of Cardiovascular Disease
    NIH/NHLBI T32HL007731Jul 1, 1992 - May 31, 2023
    Role: Principal Investigator
    Molecular Mechanisms of Protease Signaling
    NIH/NHLBI R01HL044907Apr 1, 1991 - Mar 31, 2010
    Role: Principal Investigator
    CELL AND MOLECULES MEDIATING GRAFT ATHEROSCLEROSIS
    NIH/NHLBI R01HL043322Jul 1, 1989 - Apr 30, 1994
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Protease-Activated Receptor-2 Regulates Neuro-Epidermal Communication in Atopic Dermatitis. Front Immunol. 2020; 11:1740. Buhl T, Ikoma A, Kempkes C, Cevikbas F, Sulk M, Buddenkotte J, Akiyama T, Crumrine D, Camerer E, Carstens E, Schön MP, Elias P, Coughlin SR, Steinhoff M. PMID: 32903402.
      View in: PubMed   Mentions:    Fields:    
    2. Designing a Green Fluorogenic Protease Reporter by Flipping a Beta Strand of GFP for Imaging Apoptosis in Animals. J Am Chem Soc. 2019 03 20; 141(11):4526-4530. Zhang Q, Schepis A, Huang H, Yang J, Ma W, Torra J, Zhang SQ, Yang L, Wu H, Nonell S, Dong Z, Kornberg TB, Coughlin SR, Shu X. PMID: 30821975.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. Biochemistry. 2018 10 02; 57(39):5748-5758. Bokoch MP, Jo H, Valcourt JR, Srinivasan Y, Pan AC, Capponi S, Grabe M, Dror RO, Shaw DE, DeGrado WF, Coughlin SR. PMID: 30102523.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish. Dev Cell. 2018 07 02; 46(1):112-125.e4. Wu RS, Lam II, Clay H, Duong DN, Deo RC, Coughlin SR. PMID: 29974860.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    5. A rapid fluorogenic GPCR-ß-arrestin interaction assay. Protein Sci. 2018 04; 27(4):874-879. Zhang Q, Zheng YW, Coughlin SR, Shu X. PMID: 29411438.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 01 18; 69(2):347. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. PMID: 29351851.
      View in: PubMed   Mentions: 3     Fields:    
    7. Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Sci Signal. 2018 01 16; 11(513). Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A. PMID: 29339534.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    8. Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent. Structure. 2018 02 06; 26(2):187-198.e4. Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL, Coughlin SR. PMID: 29336885.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. J Cell Biol. 2018 03 05; 217(3):1097-1112. Schepis A, Barker A, Srinivasan Y, Balouch E, Zheng Y, Lam I, Clay H, Hsiao CD, Coughlin SR. PMID: 29301867.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 01 18; 69(2):334-346.e4. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. PMID: 29307513.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    11. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. PMID: 28329764.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    12. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circ Res. 2016 Sep 30; 119(8):e110-26. Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E. PMID: 27582371.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    13. Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis. Sci Transl Med. 2016 08 24; 8(353):353ra112. David T, Kim YC, Ely LK, Rondon I, Gao H, O'Brien P, Bolt MW, Coyle AJ, Garcia JL, Flounders EA, Mikita T, Coughlin SR. PMID: 27559095.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    14. Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis In Vivo. Cell Chem Biol. 2016 07 21; 23(7):875-882. To TL, Schepis A, Ruiz-González R, Zhang Q, Yu D, Dong Z, Coughlin SR, Shu X. PMID: 27447051.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development. Dev Biol. 2016 10 01; 418(1):157-165. Clay H, Wilsbacher LD, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin SR. PMID: 27333774.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    16. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016 Apr 12; 7:11303. Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DYR, Gollob MH. PMID: 27066836.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    17. Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM. Nat Commun. 2015 Nov 12; 6:8857. Pfreundschuh M, Alsteens D, Wieneke R, Zhang C, Coughlin SR, Tampé R, Kobilka BK, Müller DJ. PMID: 26561004.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    18. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015 Oct 16; 4:e09406. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin SR, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. PMID: 26473617.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    19. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nat Commun. 2015 Oct 01; 6:8448. Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS. PMID: 26423607.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    20. Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. 2015 Oct 22; 126(17):2047-58. Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin SR, Degen JL, Flick MJ. PMID: 26228483.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    21. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape. Nat Methods. 2015 Sep; 12(9):845-851. Alsteens D, Pfreundschuh M, Zhang C, Spoerri PM, Coughlin SR, Kobilka BK, Müller DJ. PMID: 26167642.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    22. Analysis of cardiomyocyte development using immunofluorescence in embryonic mouse heart. J Vis Exp. 2015 Mar 26; (97). Wilsbacher LD, Coughlin SR. PMID: 25866997.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    23. Gai/o-coupled receptor signaling restricts pancreatic ß-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2888-93. Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS. PMID: 25695968.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    24. Mechanical vessel injury in zebrafish embryos. J Vis Exp. 2015 Feb 17; (96):e52460. Clay H, Coughlin SR. PMID: 25742284.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    25. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 2014 Nov 27; 124(23):3450-8. Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. PMID: 25293779.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    26. Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2563-9. Bynagari-Settipalli YS, Cornelissen I, Palmer D, Duong D, Concengco C, Ware J, Coughlin SR. PMID: 25278288.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    27. The imperative to invest in science has never been greater. J Clin Invest. 2014 Sep; 124(9):3680-1. Carethers JM, Coughlin S, Diamond B, Erzurum S, Fried LP, Jameson JL, Kaushansky K, Klotman ME, Lemon S, Mitchell B, Rothman P, Sawyers C, Seidman C, Somlo S. PMID: 25180532.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    28. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 03; 502(7469):105-9. Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L. PMID: 23995678.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    29. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin SR, McDonald DM, McCune JM. PMID: 23657000.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    30. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012 Dec 20; 492(7429):387-92. Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. PMID: 23222541.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansCells
    31. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest. 2013 Jan; 123(1):206-14. Khoufache K, Berri F, Nacken W, Vogel AB, Delenne M, Camerer E, Coughlin SR, Carmeliet P, Lina B, Rimmelzwaan GF, Planz O, Ludwig S, Riteau B. PMID: 23202729.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    32. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell. 2012 Sep 28; 151(1):111-22. Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin SR, Jan YN, Jan LY. PMID: 23021219.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    33. Wnt/ß-catenin signaling is differentially regulated by Ga proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20101-6. Regard JB, Cherman N, Palmer D, Kuznetsov SA, Celi FS, Guettier JM, Chen M, Bhattacharyya N, Wess J, Coughlin SR, Weinstein LS, Collins MT, Robey PG, Yang Y. PMID: 22106277.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    34. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science. 2011 Sep 30; 333(6051):1898-903. Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. PMID: 21960637.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    35. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood. 2011 Oct 13; 118(15):4015-23. Shao B, Wahrenbrock MG, Yao L, David T, Coughlin SR, Xia L, Varki A, McEver RP. PMID: 21860019.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    36. The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011 Jun 05; 12(7):672-80. Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin SR, Cyster JG. PMID: 21642988.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    37. PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nat Commun. 2011 Jan 18; 2:161. Frateschi S, Camerer E, Crisante G, Rieser S, Membrez M, Charles RP, Beermann F, Stehle JC, Breiden B, Sandhoff K, Rotman S, Haftek M, Wilson A, Ryser S, Steinhoff M, Coughlin SR, Hummler E. PMID: 21245842.
      View in: PubMed   Mentions: 34     Fields:    
    38. Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18605-10. Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin SR. PMID: 20930120.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    39. Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group. Circulation. 2010 Mar 30; 121(12):1447-54. Eagle KA, Ginsburg GS, Musunuru K, Aird WC, Balaban RS, Bennett SK, Blumenthal RS, Coughlin SR, Davidson KW, Frohlich ED, Greenland P, Jarvik GP, Libby P, Pepine CJ, Ruskin JN, Stillman AE, Van Eyk JE, Tolunay HE, McDonald CL, Smith SC. PMID: 20351302.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    40. Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010 Jan 19; 18(1):25-38. Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, Kirchhofer D, Coughlin SR. PMID: 20152175.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    41. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med. 2010 Jan 18; 207(1):17-27. Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin SR, McDonald DM, Schwab SR, Cyster JG. PMID: 20026661.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    42. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest. 2009 Jul; 119(7):1871-9. Camerer E, Regard JB, Cornelissen I, Srinivasan Y, Duong DN, Palmer D, Pham TH, Wong JS, Pappu R, Coughlin SR. PMID: 19603543.
      View in: PubMed   Mentions: 150     Fields:    Translation:Animals
    43. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development. 2009 Jan; 136(2):327-35. Li G, Kataoka H, Coughlin SR, Pleasure SJ. PMID: 19103804.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    44. Anatomical profiling of G protein-coupled receptor expression. Cell. 2008 Oct 31; 135(3):561-71. Regard JB, Sato IT, Coughlin SR. PMID: 18984166.
      View in: PubMed   Mentions: 188     Fields:    Translation:AnimalsCells
    45. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol. 2008 Jun 30; 181(7):1211-22. Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. PMID: 18573917.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    46. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. Blood. 2008 Aug 01; 112(3):585-91. Sood R, Sholl L, Isermann B, Zogg M, Coughlin SR, Weiler H. PMID: 18490515.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    47. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest. 2008 Mar; 118(3):1123-31. Cho J, Furie BC, Coughlin SR, Furie B. PMID: 18292814.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    48. Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest. 2007 Dec; 117(12):4034-43. Regard JB, Kataoka H, Cano DA, Camerer E, Yin L, Zheng YW, Scanlan TS, Hebrok M, Coughlin SR. PMID: 17992256.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    49. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. J Exp Med. 2007 May 14; 204(5):1049-56. Sood R, Zogg M, Westrick RJ, Guo YH, Kerschen EJ, Girardi G, Salmon JE, Coughlin SR, Weiler H. PMID: 17438064.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    50. Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology. 2007 Jun; 132(7):2422-37. Cottrell GS, Amadesi S, Pikios S, Camerer E, Willardsen JA, Murphy BR, Caughey GH, Wolters PJ, Coughlin SR, Peterson A, Knecht W, Pothoulakis C, Bunnett NW, Grady EF. PMID: 17570216.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    51. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science. 2007 Apr 13; 316(5822):295-8. Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, Coughlin SR. PMID: 17363629.
      View in: PubMed   Mentions: 346     Fields:    Translation:AnimalsCells
    52. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):288-92. Vandendries ER, Hamilton JR, Coughlin SR, Furie B, Furie BC. PMID: 17190826.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    53. Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site. J Virol. 2006 Dec; 80(23):11510-9. Yuan J, Stein DA, Lim T, Qiu D, Coughlin S, Liu Z, Wang Y, Blouch R, Moulton HM, Iversen PL, Yang D. PMID: 16987987.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    54. Roles of protease-activated receptors in a mouse model of endotoxemia. Blood. 2006 May 15; 107(10):3912-21. Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin SR. PMID: 16434493.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    55. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005 Aug 15; 175(4):2598-605. Su X, Camerer E, Hamilton JR, Coughlin SR, Matthay MA. PMID: 16081834.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    56. Essential role for Galpha13 in endothelial cells during embryonic development. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8281-6. Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR. PMID: 15919816.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    57. PAR1 cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 2005 Apr 01; 280(13):13122-8. Ludeman MJ, Kataoka H, Srinivasan Y, Esmon NL, Esmon CT, Coughlin SR. PMID: 15665002.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    58. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood. 2004 Jul 15; 104(2):397-401. Camerer E, Qazi AA, Duong DN, Cornelissen I, Advincula R, Coughlin SR. PMID: 15031212.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    59. Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. J Biol Chem. 2004 Apr 30; 279(18):18592-9. Ludeman MJ, Zheng YW, Ishii K, Coughlin SR. PMID: 14982936.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    60. Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency. Blood. 2004 Jan 01; 103(1):152-4. Camerer E, Duong DN, Hamilton JR, Coughlin SR. PMID: 14504091.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    61. Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood. 2003 Nov 01; 102(9):3224-31. Kataoka H, Hamilton JR, McKemy DD, Camerer E, Zheng YW, Cheng A, Griffin C, Coughlin SR. PMID: 12869501.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
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