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Shaun Coughlin, MD, PhD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
DepartmentCardiovascular Research Inst
Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-502-8667
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    Other Positions
    TitleDirector, Cardiovascular Research Institute


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPost-Doc Fellow/Scholar1986School of Medicine
    University of California, San Francisco Residency School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Structure-Function and Roles of Protease-Activated Receptors
    NIH/NHLBI R35HL135755Feb 14, 2017 - Dec 31, 2023
    Role: Principal Investigator
    Structural Basis of Protease-Activated Receptor Function
    NIH/NHLBI R01HL121387Jan 15, 2014 - Dec 31, 2017
    Role: Principal Investigator
    PARs and S1P receptors in endothelial biology
    NIH/NHLBI R01HL065590Sep 30, 2000 - May 31, 2014
    Role: Principal Investigator
    Thrombin signaling in Hemostatis and thrombosis
    NIH/NHLBI R01HL065185Sep 5, 2000 - Nov 30, 2012
    Role: Principal Investigator
    Protease-activated receptors in inflammation
    NIH/NHLBI R01HL059202Jan 1, 1998 - Mar 31, 2008
    Role: Principal Investigator
    Molecular Genetics of Cardiac Cell Differentiation
    NIH/NHLBI R01HL054737Apr 1, 1996 - Jun 30, 2016
    Role: Principal Investigator
    MURINE MODELS TO INVESTIGATE THE HEMATOLOGIC SYSTEM
    NIH/NIDDK P01DK050267Aug 15, 1995 - Jul 31, 2001
    Role: Co-Principal Investigator
    GORDON CONFERENCE--ATHEROSCLEROSIS 1993
    NIH/NHLBI R13HL050524Aug 1, 1993 - Jul 31, 1994
    Role: Principal Investigator
    Molecular and Cellular Basis of Cardiovascular Disease
    NIH/NHLBI T32HL007731Jul 1, 1992 - Aug 31, 2017
    Role: Principal Investigator
    Molecular Mechanisms of Protease Signaling
    NIH/NHLBI R01HL044907Apr 1, 1991 - Mar 31, 2010
    Role: Principal Investigator
    CELL AND MOLECULES MEDIATING GRAFT ATHEROSCLEROSIS
    NIH/NHLBI R01HL043322Jul 1, 1989 - Apr 30, 1994
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Zhang Q, Zheng YW, Coughlin S, Shu X. A rapid fluorogenic GPCR-ß-arrestin interaction assay. Protein Sci. 2018 Apr; 27(4):874-879. PMID: 29411438.
      View in: PubMed
    2. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin S, Kornberg TB, Shu X. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 Jan 18; 69(2):347. PMID: 29351851.
      View in: PubMed
    3. Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A. Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia. Sci Signal. 2018 Jan 16; 11(513). PMID: 29339534.
      View in: PubMed
    4. Schepis A, Barker A, Srinivasan Y, Balouch E, Zheng Y, Lam I, Clay H, Hsiao CD, Coughlin S. Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia. J Cell Biol. 2018 Mar 05; 217(3):1097-1112. PMID: 29301867.
      View in: PubMed
    5. Zhang Q, Huang H, Zhang L, Wu R, Chung CI, Zhang SQ, Torra J, Schepis A, Coughlin S, Kornberg TB, Shu X. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018 Jan 18; 69(2):334-346.e4. PMID: 29307513.
      View in: PubMed
    6. Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL, Coughlin S. Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent. Structure. 2018 Jan 02. PMID: 29336885.
      View in: PubMed
    7. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin S, Krummel MF, Leavitt AD, Passegué E, Looney MR. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. PMID: 28329764.
      View in: PubMed
    8. Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin S, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circ Res. 2016 Sep 30; 119(8):e110-26. PMID: 27582371.
      View in: PubMed
    9. David T, Kim YC, Ely LK, Rondon I, Gao H, O'Brien P, Bolt MW, Coyle AJ, Garcia JL, Flounders EA, Mikita T, Coughlin S. Factor XIa-specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis. Sci Transl Med. 2016 08 24; 8(353):353ra112. PMID: 27559095.
      View in: PubMed
    10. To TL, Schepis A, Ruiz-González R, Zhang Q, Yu D, Dong Z, Coughlin S, Shu X. Rational Design of a GFP-Based Fluorogenic Caspase Reporter for Imaging Apoptosis In Vivo. Cell Chem Biol. 2016 Jul 21; 23(7):875-882. PMID: 27447051.
      View in: PubMed
    11. Clay H, Wilsbacher LD, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin S. Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development. Dev Biol. 2016 10 01; 418(1):157-165. PMID: 27333774.
      View in: PubMed
    12. Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin S, Stainier DY, Gollob MH. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016 Apr 12; 7:11303. PMID: 27066836; PMCID: PMC4832069.
    13. Pfreundschuh M, Alsteens D, Wieneke R, Zhang C, Coughlin S, Tampé R, Kobilka BK, Müller DJ. Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM. Nat Commun. 2015 Nov 12; 6:8857. PMID: 26561004; PMCID: PMC4660198.
    14. Zou J, Tran D, Baalbaki M, Tang LF, Poon A, Pelonero A, Titus EW, Yuan C, Shi C, Patchava S, Halper E, Garg J, Movsesyan I, Yin C, Wu R, Wilsbacher LD, Liu J, Hager RL, Coughlin S, Jinek M, Pullinger CR, Kane JP, Hart DO, Kwok PY, Deo RC. An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish. Elife. 2015 Oct 16; 4:e09406. PMID: 26473617; PMCID: PMC4720518.
    15. Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin S, Craik CS. Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nat Commun. 2015 Oct 01; 6:8448. PMID: 26423607; PMCID: PMC4593073.
    16. Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin S, Degen JL, Flick MJ. Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. 2015 Oct 22; 126(17):2047-58. PMID: 26228483; PMCID: PMC4616238.
    17. Alsteens D, Pfreundschuh M, Zhang C, Spoerri PM, Coughlin S, Kobilka BK, Müller DJ. Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape. Nat Methods. 2015 Sep; 12(9):845-851. PMID: 26167642.
      View in: PubMed
    18. Wilsbacher LD, Coughlin S. Analysis of cardiomyocyte development using immunofluorescence in embryonic mouse heart. J Vis Exp. 2015 Mar 26; (97). PMID: 25866997; PMCID: PMC4401388.
    19. Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin S, Conklin BR, Deneris ES, Tecott LH, German MS. Gai/o-coupled receptor signaling restricts pancreatic ß-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2888-93. PMID: 25695968; PMCID: PMC4352814.
    20. Clay H, Coughlin S. Mechanical vessel injury in zebrafish embryos. J Vis Exp. 2015 Feb 17; (96):e52460. PMID: 25742284; PMCID: PMC4354638.
    21. Edelstein LC, Simon LM, Lindsay CR, Kong X, Teruel-Montoya R, Tourdot BE, Chen ES, Ma L, Coughlin S, Nieman M, Holinstat M, Shaw CA, Bray PF. Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race. Blood. 2014 Nov 27; 124(23):3450-8. PMID: 25293779; PMCID: PMC4246040.
    22. Bynagari-Settipalli YS, Cornelissen I, Palmer D, Duong D, Concengco C, Ware J, Coughlin S. Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2563-9. PMID: 25278288; PMCID: PMC4239193.
    23. Carethers JM, Coughlin S, Diamond B, Erzurum S, Fried LP, Jameson JL, Kaushansky K, Klotman ME, Lemon S, Mitchell B, Rothman P, Sawyers C, Seidman C, Somlo S. The imperative to invest in science has never been greater. J Clin Invest. 2014 Sep; 124(9):3680-1. PMID: 25180532; PMCID: PMC4151225.
    24. Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin S, McEver RP, Chen H, Kahn ML, Xia L. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013 Oct 03; 502(7469):105-9. PMID: 23995678; PMCID: PMC3791160.
    25. Miller CN, Hartigan-O'Connor DJ, Lee MS, Laidlaw G, Cornelissen IP, Matloubian M, Coughlin S, McDonald DM, McCune JM. IL-7 production in murine lymphatic endothelial cells and induction in the setting of peripheral lymphopenia. Int Immunol. 2013 Aug; 25(8):471-83. PMID: 23657000; PMCID: PMC3720065.
    26. Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin S, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012 Dec 20; 492(7429):387-92. PMID: 23222541; PMCID: PMC3531875.
    27. Khoufache K, Berri F, Nacken W, Vogel AB, Delenne M, Camerer E, Coughlin S, Carmeliet P, Lina B, Rimmelzwaan GF, Planz O, Ludwig S, Riteau B. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest. 2013 Jan; 123(1):206-14. PMID: 23202729; PMCID: PMC3533265.
    28. Yang H, Kim A, David T, Palmer D, Jin T, Tien J, Huang F, Cheng T, Coughlin S, Jan YN, Jan LY. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell. 2012 Sep 28; 151(1):111-22. PMID: 23021219; PMCID: PMC3582364.
    29. Regard JB, Cherman N, Palmer D, Kuznetsov SA, Celi FS, Guettier JM, Chen M, Bhattacharyya N, Wess J, Coughlin S, Weinstein LS, Collins MT, Robey PG, Yang Y. Wnt/ß-catenin signaling is differentially regulated by Ga proteins and contributes to fibrous dysplasia. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20101-6. PMID: 22106277; PMCID: PMC3250124.
    30. Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science. 2011 Sep 30; 333(6051):1898-903. PMID: 21960637; PMCID: PMC3267326.
    31. Shao B, Wahrenbrock MG, Yao L, David T, Coughlin S, Xia L, Varki A, McEver RP. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood. 2011 Oct 13; 118(15):4015-23. PMID: 21860019; PMCID: PMC3204725.
    32. Green JA, Suzuki K, Cho B, Willison LD, Palmer D, Allen CD, Schmidt TH, Xu Y, Proia RL, Coughlin S, Cyster JG. The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011 Jun 05; 12(7):672-80. PMID: 21642988; PMCID: PMC3158008.
    33. Frateschi S, Camerer E, Crisante G, Rieser S, Membrez M, Charles RP, Beermann F, Stehle JC, Breiden B, Sandhoff K, Rotman S, Haftek M, Wilson A, Ryser S, Steinhoff M, Coughlin S, Hummler E. PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin. Nat Commun. 2011 Jan 18; 2:161. PMID: 21245842.
      View in: PubMed
    34. Cornelissen I, Palmer D, David T, Wilsbacher L, Concengco C, Conley P, Pandey A, Coughlin S. Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18605-10. PMID: 20930120; PMCID: PMC2972928.
    35. Eagle KA, Ginsburg GS, Musunuru K, Aird WC, Balaban RS, Bennett SK, Blumenthal RS, Coughlin S, Davidson KW, Frohlich ED, Greenland P, Jarvik GP, Libby P, Pepine CJ, Ruskin JN, Stillman AE, Van Eyk JE, Tolunay HE, McDonald CL, Smith SC. Identifying patients at high risk of a cardiovascular event in the near future: current status and future directions: report of a national heart, lung, and blood institute working group. Circulation. 2010 Mar 30; 121(12):1447-54. PMID: 20351302.
      View in: PubMed
    36. Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, Kirchhofer D, Coughlin S. Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010 Jan 19; 18(1):25-38. PMID: 20152175; PMCID: PMC2822780.
    37. Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, Coughlin S, McDonald DM, Schwab SR, Cyster JG. Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med. 2010 Jan 18; 207(1):17-27. PMID: 20026661; PMCID: PMC2812554.
    38. Camerer E, Regard JB, Cornelissen I, Srinivasan Y, Duong DN, Palmer D, Pham TH, Wong JS, Pappu R, Coughlin S. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest. 2009 Jul; 119(7):1871-9. PMID: 19603543; PMCID: PMC2701879.
    39. Li G, Kataoka H, Coughlin S, Pleasure SJ. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development. 2009 Jan; 136(2):327-35. PMID: 19103804; PMCID: PMC2685973.
    40. Regard JB, Sato IT, Coughlin S. Anatomical profiling of G protein-coupled receptor expression. Cell. 2008 Oct 31; 135(3):561-71. PMID: 18984166; PMCID: PMC2590943.
    41. Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol. 2008 Jun 30; 181(7):1211-22. PMID: 18573917.
      View in: PubMed
    42. Sood R, Sholl L, Isermann B, Zogg M, Coughlin S, Weiler H. Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin. Blood. 2008 Aug 01; 112(3):585-91. PMID: 18490515; PMCID: PMC2481555.
    43. Cho J, Furie BC, Coughlin S, Furie B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest. 2008 Mar; 118(3):1123-31. PMID: 18292814; PMCID: PMC2248441.
    44. Regard JB, Kataoka H, Cano DA, Camerer E, Yin L, Zheng YW, Scanlan TS, Hebrok M, Coughlin S. Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest. 2007 Dec; 117(12):4034-43. PMID: 17992256; PMCID: PMC2066199.
    45. Sood R, Zogg M, Westrick RJ, Guo YH, Kerschen EJ, Girardi G, Salmon JE, Coughlin S, Weiler H. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. J Exp Med. 2007 May 14; 204(5):1049-56. PMID: 17438064; PMCID: PMC2118565.
    46. Cottrell GS, Amadesi S, Pikios S, Camerer E, Willardsen JA, Murphy BR, Caughey GH, Wolters PJ, Coughlin S, Peterson A, Knecht W, Pothoulakis C, Bunnett NW, Grady EF. Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis. Gastroenterology. 2007 Jun; 132(7):2422-37. PMID: 17570216; PMCID: PMC2366898.
    47. Pappu R, Schwab SR, Cornelissen I, Pereira JP, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, Coughlin S. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science. 2007 Apr 13; 316(5822):295-8. PMID: 17363629.
      View in: PubMed
    48. Vandendries ER, Hamilton JR, Coughlin S, Furie B, Furie BC. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):288-92. PMID: 17190826; PMCID: PMC1765451.
    49. Yuan J, Stein DA, Lim T, Qiu D, Coughlin S, Liu Z, Wang Y, Blouch R, Moulton HM, Iversen PL, Yang D. Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site. J Virol. 2006 Dec; 80(23):11510-9. PMID: 16987987; PMCID: PMC1642606.
    50. Camerer E, Cornelissen I, Kataoka H, Duong DN, Zheng YW, Coughlin S. Roles of protease-activated receptors in a mouse model of endotoxemia. Blood. 2006 May 15; 107(10):3912-21. PMID: 16434493; PMCID: PMC1895289.
    51. Su X, Camerer E, Hamilton JR, Coughlin S, Matthay MA. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol. 2005 Aug 15; 175(4):2598-605. PMID: 16081834.
      View in: PubMed
    52. Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin S. Essential role for Galpha13 in endothelial cells during embryonic development. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8281-6. PMID: 15919816; PMCID: PMC1149452.
    53. Ludeman MJ, Kataoka H, Srinivasan Y, Esmon NL, Esmon CT, Coughlin S. PAR1 cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 2005 Apr 01; 280(13):13122-8. PMID: 15665002.
      View in: PubMed
    54. Camerer E, Qazi AA, Duong DN, Cornelissen I, Advincula R, Coughlin S. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood. 2004 Jul 15; 104(2):397-401. PMID: 15031212.
      View in: PubMed
    55. Ludeman MJ, Zheng YW, Ishii K, Coughlin S. Regulated shedding of PAR1 N-terminal exodomain from endothelial cells. J Biol Chem. 2004 Apr 30; 279(18):18592-9. PMID: 14982936.
      View in: PubMed
    56. Camerer E, Duong DN, Hamilton JR, Coughlin S. Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency. Blood. 2004 Jan 01; 103(1):152-4. PMID: 14504091.
      View in: PubMed
    57. Kataoka H, Hamilton JR, McKemy DD, Camerer E, Zheng YW, Cheng A, Griffin C, Coughlin S. Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells. Blood. 2003 Nov 01; 102(9):3224-31. PMID: 12869501.
      View in: PubMed
    58. Eisenhaure TM, Francis SA, Willison LD, Coughlin S, Lerner DJ. The Rho guanine nucleotide exchange factor Lsc homo-oligomerizes and is negatively regulated through domains in its carboxyl terminus that are absent in novel splenic isoforms. J Biol Chem. 2003 Aug 15; 278(33):30975-84. PMID: 12773540.
      View in: PubMed
    59. Coughlin S, Camerer E. PARticipation in inflammation. J Clin Invest. 2003 Jan; 111(1):25-7. PMID: 12511583; PMCID: PMC151847.
    60. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin S, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. PMID: 12478301.
      View in: PubMed
    61. Weiss EJ, Hamilton JR, Lease KE, Coughlin S. Protection against thrombosis in mice lacking PAR3. Blood. 2002 Nov 01; 100(9):3240-4. PMID: 12384423.
      View in: PubMed
    62. Camerer E, Kataoka H, Kahn M, Lease K, Coughlin S. Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. J Biol Chem. 2002 May 03; 277(18):16081-7. PMID: 11850418.
      View in: PubMed
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