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Holly Ingraham, PhD

Title(s)Professor, Cellular Molecular Pharmacology
SchoolSchool of Medicine
Address1550 Fourth St
San Francisco CA 94158
Phone415-476-3401
EmailHolly.Ingraham@ucsf.edu
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    Collapse Biography 
    Collapse Awards and Honors
    1991Genentech Human Growth Foundation Award
    1997NIH Independent Scientist Award
    2002Brook Byers Basic Science Award
    2012Elected Fellow of American Association for Advancement of Science (AAAS)
    2006Herzstein Distinguished Investigator in Molecular Physiology
    2017Chancellor’s Award Martin Luther King, Jr. (MLK) Leadership
    2018Joseph Larner Memorial Lectureship Award in Pharmacology
    2019Elected American Academy of Arts and Science (AAA&S)
    201942nd Annual Steenbock Lectureship Award in Biochemistry

    Collapse Overview 
    Collapse Overview
    About our Reserch: Please visit my website at https://ingrahamlab.ucsf.edu on our current research efforts on the basic science of "Hormones and Nerves in Female Physiology" aimed at improving women's health.

    About Me: Those who devote their lives to creative pursuits are often inspired by a singular event. Mine came from my great-grandfather, whose 1890 Bausch & Lomb microscope, abandoned in a closet after being shipped west from Worcester Massachusetts, came into my possession when I was 10 years old. I picked it up and began exploring the biological world of Northern California, never to stop. But sporadic events are not enough to support a lifetime of curiosity and discovery. That support would come via the State of California through an amazing and accessible public education system beginning at Revelle College at UCSD, and through the NIH, which has supported my curiosity-based discovery research program continuoulsy for over 25 years. Unwavering support also comes from my family and mentors who provide the personal strength and resiliency needed to overcome moments of disappointment, insecurity, and self-doubt. I thoroughly enjoy my life as a scientist and continue to be addicted to the rare experimental successes sprinkled among the many failures inherent in the scientific process.

    About Diversity: In partnership with San Francisco State University, I also direct the UCSF IRACDA Scholars Program to build diversity in our nation's biomedical workforce and faculty. Our efforts along with generous funding from an NIGMS K12 grant and the UCSF School of Medicine provide career development programming for a cohort of postdoctoral fellows. With Ms. Anne Sufka, we recently launched Path-To-Postdoc@UCSF Program, a funded opportunity for prospective fellows to interact with UCSF's vibrant research community. Our local efforts today will make a national difference tomorrow.

    Collapse Research 
    Collapse Research Activities and Funding
    Dissecting a hormone-responsive processor for female activity and repetitive behavior
    NIH/NIDDK R01DK121657Mar 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Arcuate ERa Signaling in Central Control of Female Bone Metabolism
    NIH/NIA R01 AG062331-01A1Oct 1, 2019 - Sep 30, 2024
    Role: Pincipal Investigator
    Mapping gut-spinal cord connections in visceral pain
    NIH/NINDS U01 NS113869Oct 1, 2019 - Sep 30, 2022
    Role: Co-Principal Investigator
    Arcuate ERa Signaling in Central Control of Female Bone Metabolism
    NIH/NIA R01AG062331Sep 30, 2019 - May 31, 2024
    Role: Principal Investigator
    UCSF Nutrition Obesity Research Center
    NIH/NIDDK P30DK098722Aug 1, 2015 - Jul 31, 2020
    Role: Co-Investigator
    Mapping Hypothalamic Neurocircuits Controlling Physical Activity
    NIH/NIDDK R01DK099722Apr 1, 2014 - Mar 31, 2019
    Role: Principal Investigator
    Modulating Nuclear Receptor Activity via Sumoylation
    NIH/NIDDK R01DK070024Feb 1, 2010 - Jul 31, 2013
    Role: Principal Investigator
    Molecular Mechanisms of Atrazine in Altering the Endocrine Gene Network
    NIH/NIEHS R21ES017136Aug 15, 2009 - Jun 30, 2011
    Role: Principal Investigator
    UCSF IRACDA Scholars Program
    NIH/NIGMS K12GM081266Aug 3, 2007 - Jul 31, 2022
    Role: Principal Investigator
    Structural Analyses of NR5 Orphan Nuclear Receptors
    NIH/NIDDK R01DK072246Jul 15, 2005 - May 31, 2012
    Role: Principal Investigator
    STRUCTURE AND DYNAMICS OF NUCLEAR RECEPTORS
    NIH/NIDDK P01DK058390Aug 15, 2000 - Jul 31, 2006
    Role: Co-Investigator
    30TH GORDON CONFERENCE ON HORMONE ACTION
    NIH/NIDDK R13DK056229Jul 15, 1999 - Jun 30, 2000
    Role: Principal Investigator
    CELLULAR SIGNALING IN REPRODUCTIVE TRACT DEVELOPMENT
    NIH/NICHD R01HD036233Apr 15, 1998 - Mar 31, 2004
    Role: Principal Investigator
    GENE EXPRESSION IN MAMMALIAN REPRODUCTIVE DEVELOPMENT
    NIH/NICHD K02HD001178Jul 1, 1997 - Jun 30, 2002
    Role: Principal Investigator
    Developmental Programs of Neural Circuits in the Mouse Medial Hypothalamus
    NIH/NIDDK R01DK063592Aug 1, 1993 - Mar 31, 2014
    Role: Principal Investigator
    GENE REGULATION IN MAMMALIAN SEX DETERMINATION
    NIH/NICHD R01HD030725Aug 1, 1993 - Jul 31, 2002
    Role: Principal Investigator
    MOLECULAR ANALYSIS OF PITUITARY DEVELOPMENT
    NIH/NIDDK R01DK046048Jul 1, 1993 - Jun 30, 1997
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SPARC - Mapping Gut-Spinal Cord Connections in Visceral Pain. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Ryan David Morrie, James Bayrer, Stuart Brierley, Holly Ingraham, David Julius. .
      View in: Publisher Site   Mentions:
    2. Should We Make More Bone or Not, As Told by Kisspeptin Neurons in the Arcuate Nucleus. Semin Reprod Med. 2019 05; 37(3):147-150. Herber CB, Ingraham HA. PMID: 31869843.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. . 2019 Sep 12. Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA. .
      View in: Publisher Site   Mentions:
    4. 948 – Nuclear Receptor Liver Receptor Homolog-1 Promotes Intestinal Notch Signaling and Enteroendocrine Cell Development. Gastroenterology. 2019 May 1; 156(6):s-202. Pervinder K. Choksi, Holly A. Ingraham, James Bayrer. .
      View in: Publisher Site   Mentions:
    5. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nat Commun. 2019 01 11; 10(1):163. Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA. PMID: 30635563.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    6. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 10 10; 9(1):4055. Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. PMID: 30305617.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    7. 273 - Nuclear Receptor LRH-1 Mitigates Intestinal Inflammatory Disease by Promoting Stem Cell Survival and Directing Normal Epithelial Composition. Gastroenterology. 2018 May 1; 154(6):s-67. James Bayrer, Hazel Escusa, Ophir D. Kein, Holly Ingraham. .
      View in: Publisher Site   Mentions:
    8. LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity. JCI Insight. 2018 03 08; 3(5). Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA. PMID: 29515023.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1. Development. 2017 10 15; 144(20):3798-3807. Xing Y, Morohashi KI, Ingraham HA, Hammer GD. PMID: 28893949.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. Cell. 2017 Jun 29; 170(1):185-198.e16. Bellono NW, Bayrer JR, Leitch DB, Castro J, Zhang C, O'Donnell TA, Brierley SM, Ingraham HA, Julius D. PMID: 28648659.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    11. Origins and Functions of the Ventrolateral VMH: A Complex Neuronal Cluster Orchestrating Sex Differences in Metabolism and Behavior. Adv Exp Med Biol. 2017; 1043:199-213. Krause WC, Ingraham HA. PMID: 29224096.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor 1 Neurons via Upregulation of Diacylglycerol Lipase-a. Neuroendocrinology. 2017; 105(4):341-356. Conde K, Fabelo C, Krause WC, Propst R, Goethel J, Fischer D, Hur J, Meza C, Ingraham HA, Wagner EJ. PMID: 27871072.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    13. Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2). PLoS One. 2016; 11(7):e0159316. de Jesus Cortez F, Suzawa M, Irvy S, Bruning JM, Sablin E, Jacobson MP, Fletterick RJ, Ingraham HA, England PM. PMID: 27467220.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. Elife. 2015 Dec 11; 4. Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. PMID: 26653140.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket. J Struct Biol. 2015 Dec; 192(3):342-348. Sablin EP, Blind RD, Uthayaruban R, Chiu HJ, Deacon AM, Das D, Ingraham HA, Fletterick RJ. PMID: 26416531.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    16. Sex-dependent changes in metabolism and behavior, as well as reduced anxiety after eliminating ventromedial hypothalamus excitatory output. Mol Metab. 2015 Nov; 4(11):857-66. Cheung CC, Krause WC, Edwards RH, Yang CF, Shah NM, Hnasko TS, Ingraham HA. PMID: 26629409.
      View in: PubMed   Mentions: 13     Fields:    
    17. Tu1824 Targeting Intestinal Stem Cells to Promote Healing in Inflammatory Bowel Disease. Gastroenterology. 2015 Apr 1; 148(4):s-911-s-912. James R. Bayrer, Robert Fletterick, Holly Ingraham. .
      View in: Publisher Site   Mentions:
    18. The Signaling Phospholipid PIP3 Functions As a Ligand Hormone For Nuclear Receptors. The FASEB Journal. 2015 Apr 1; 29. Holly Ingraham, Raymond Blind, Elena Sablin, Debanu Das, Robert Fletterick. .
      View in: Publisher Site   Mentions:
    19. An estrogen-responsive module in the ventromedial hypothalamus selectively drives sex-specific activity in females. Cell Rep. 2015 Jan 06; 10(1):62-74. Correa SM, Newstrom DW, Warne JP, Flandin P, Cheung CC, Lin-Moore AT, Pierce AA, Xu AW, Rubenstein JL, Ingraham HA. PMID: 25543145.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    20. The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15054-9. Blind RD, Sablin EP, Kuchenbecker KM, Chiu HJ, Deacon AM, Das D, Fletterick RJ, Ingraham HA. PMID: 25288771.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    21. Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH. J Comp Neurol. 2013 Apr 15; 521(6):1268-88. Cheung CC, Kurrasch DM, Liang JK, Ingraham HA. PMID: 22987798.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    22. Science Signaling Podcast: 19 June 2012. Science Signaling. 2012 Jun 19; 5(229):pc13-pc13. H. A. Ingraham, R. D. Blind, A. M. VanHook. .
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    23. Direct modification and activation of a nuclear receptor-PIP2 complex by the inositol lipid kinase IPMK. Sci Signal. 2012 Jun 19; 5(229):ra44. Blind RD, Suzawa M, Ingraham HA. PMID: 22715467.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    24. An affective disorder in zebrafish with mutation of the glucocorticoid receptor. Mol Psychiatry. 2013 Jun; 18(6):681-91. Ziv L, Muto A, Schoonheim PJ, Meijsing SH, Strasser D, Ingraham HA, Schaaf MJ, Yamamoto KR, Baier H. PMID: 22641177.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    25. Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Dev Cell. 2011 Aug 16; 21(2):315-27. Lee FY, Faivre EJ, Suzawa M, Lontok E, Ebert D, Cai F, Belsham DD, Ingraham HA. PMID: 21820362.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    26. Metabolism: A lipid for fat disorders. Nature. 2011 Jun 22; 474(7352):455-6. Ingraham HA. PMID: 21697939.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes. J Steroid Biochem Mol Biol. 2011 Oct; 127(1-2):64-73. Hayes TB, Anderson LL, Beasley VR, de Solla SR, Iguchi T, Ingraham H, Kestemont P, Kniewald J, Kniewald Z, Langlois VS, Luque EH, McCoy KA, Muñoz-de-Toro M, Oka T, Oliveira CA, Orton F, Ruby S, Suzawa M, Tavera-Mendoza LE, Trudeau VL, Victor-Costa AB, Willingham E. PMID: 21419222.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    28. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem. 2011 Apr 14; 54(7):2266-81. Whitby RJ, Stec J, Blind RD, Dixon S, Leesnitzer LM, Orband-Miller LA, Williams SP, Willson TM, Xu R, Zuercher WJ, Cai F, Ingraham HA. PMID: 21391689.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    29. Hypothalamic Fetal Programming of Energy Homeostasis. Obesity Before Birth. 2011 Jan 1; 30:301-319. Clement C. Cheung, Holly A. Ingraham. .
      View in: Publisher Site   Mentions:
    30. Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation. J Neurosci. 2010 Nov 10; 30(45):14925-30. Blackshaw S, Scholpp S, Placzek M, Ingraham H, Simerly R, Shimogori T. PMID: 21068293.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    31. Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25. Cell Metab. 2010 Oct 06; 12(4):398-410. Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K. PMID: 20889131.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    32. Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res. 2009 Jul 01; 69(13):5415-23. Lin BC, Suzawa M, Blind RD, Tobias SC, Bulun SE, Scanlan TS, Ingraham HA. PMID: 19549922.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    33. Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish. Neural Dev. 2009 Jun 23; 4:22. Kurrasch DM, Nevin LM, Wong JS, Baier H, Ingraham HA. PMID: 19549326.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    34. The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18390-5. Sablin EP, Woods A, Krylova IN, Hwang P, Ingraham HA, Fletterick RJ. PMID: 19015525.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    35. Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. Mol Endocrinol. 2009 Jan; 23(1):25-34. Sablin EP, Blind RD, Krylova IN, Ingraham JG, Cai F, Williams JD, Fletterick RJ, Ingraham HA. PMID: 18988706.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    36. Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1). Mol Cell Biol. 2008 Dec; 28(24):7476-86. Campbell LA, Faivre EJ, Show MD, Ingraham JG, Flinders J, Gross JD, Ingraham HA. PMID: 18838537.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    37. Nuclear Receptors, Chemistry of. Wiley Encyclopedia of Chemical Biology. 2008 May 15; 1-10. Lioudmila A. Campbell, Holly A. Ingraham. .
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    38. The herbicide atrazine activates endocrine gene networks via non-steroidal NR5A nuclear receptors in fish and mammalian cells. PLoS One. 2008 May 07; 3(5):e2117. Suzawa M, Ingraham HA. PMID: 18461179.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    39. The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning. J Neurosci. 2007 Dec 12; 27(50):13624-34. Kurrasch DM, Cheung CC, Lee FY, Tran PV, Hata K, Ingraham HA. PMID: 18077674.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    40. International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev. 2006 Dec; 58(4):798-836. Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V. PMID: 17132856.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    41. Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage. J Comp Neurol. 2006 Oct 10; 498(5):637-48. Tran PV, Akana SF, Malkovska I, Dallman MF, Parada LF, Ingraham HA. PMID: 16917842.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    42. Orphan nuclear receptors adopted by crystallography. Curr Opin Struct Biol. 2005 Dec; 15(6):708-15. Ingraham HA, Redinbo MR. PMID: 16263271.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    43. The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification. Mol Cell Biol. 2005 Mar; 25(5):1879-90. Lee MB, Lebedeva LA, Suzawa M, Wadekar SA, Desclozeaux M, Ingraham HA. PMID: 15713642.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    44. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11; 120(3):343-55. Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. PMID: 15707893.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansAnimalsCells
    45. Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function. Mol Endocrinol. 2004 Apr; 18(4):941-52. Bland ML, Fowkes RC, Ingraham HA. PMID: 14726490.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    46. UPREGULATION OF WNT4 DISRUPTS TESTICULAR VASCULOGENESIS AND INHIBITS TESTOSTERONE SYNTHESIS.: 128. Journal of Investigative Medicine. 2004 Jan 1; 52:s101. E. Vilain, J.H.-C. Shen, R. Olaso, H. A. Ingraham, B. K. Jordan. .
      View in: Publisher Site   Mentions:
    47. 128 UPREGULATION OF WNT4 DISRUPTS TESTICULAR VASCULOGENESIS AND INHIBITS TESTOSTERONE SYNTHESIS. Journal of Investigative Medicine. 2004 Jan 1; 52(Suppl 1):s101. E. Vilain, J.H.-C. Shen, R. Olaso, H. A. Ingraham, B. K. Jordan. .
      View in: Publisher Site   Mentions:
    48. Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10866-71. Jordan BK, Shen JH, Olaso R, Ingraham HA, Vilain E. PMID: 12949260.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    49. Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes. Mol Endocrinol. 2003 Nov; 17(11):2177-88. Fowkes RC, Desclozeaux M, Patel MV, Aylwin SJ, King P, Ingraham HA, Burrin JM. PMID: 12920232.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    50. Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1. Mol Cell. 2003 Jun; 11(6):1575-85. Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA. PMID: 12820970.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    51. Tissue growth and remodeling of the embryonic and adult adrenal gland. Ann N Y Acad Sci. 2003 May; 995:59-72. Bland ML, Desclozeaux M, Ingraham HA. PMID: 12814939.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    52. Requirement of the orphan nuclear receptor SF-1 in terminal differentiation of ventromedial hypothalamic neurons. Mol Cell Neurosci. 2003 Apr; 22(4):441-53. Tran PV, Lee MB, Marín O, Xu B, Jones KR, Reichardt LF, Rubenstein JR, Ingraham HA. PMID: 12727442.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    53. Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain. Mol Endocrinol. 2003 Jan; 17(1):107-16. Huber BR, Desclozeaux M, West BL, Cunha-Lima ST, Nguyen HT, Baxter JD, Ingraham HA, Fletterick RJ. PMID: 12511610.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    54. Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1. Mol Cell Biol. 2002 Oct; 22(20):7193-203. Desclozeaux M, Krylova IN, Horn F, Fletterick RJ, Ingraham HA. PMID: 12242296.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    55. Anti-Müllerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology. 2002 Mar; 143(3):1076-84. Durlinger AL, Gruijters MJ, Kramer P, Karels B, Ingraham HA, Nachtigal MW, Uilenbroek JT, Grootegoed JA, Themmen AP. PMID: 11861535.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    56. Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol Endocrinol. 2002 Mar; 16(3):529-40. Shen JH, Ingraham HA. PMID: 11875113.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    57. Involvement of a matrix metalloproteinase in MIS-induced cell death during urogenital development. Development. 2002 Mar; 129(6):1487-96. Roberts LM, Visser JA, Ingraham HA. PMID: 11880357.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    58. The serine/threonine transmembrane receptor ALK2 mediates Müllerian inhibiting substance signaling. Mol Endocrinol. 2001 Jun; 15(6):936-45. Visser JA, Olaso R, Verhoef-Post M, Kramer P, Themmen AP, Ingraham HA. PMID: 11376112.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    59. Müllerian inhibitory substance induces growth of rat preantral ovarian follicles. Biol Reprod. 2001 Jan; 64(1):293-8. McGee EA, Smith R, Spears N, Nachtigal MW, Ingraham H, Hsueh AJ. PMID: 11133686.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    60. Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14488-93. Bland ML, Jamieson CA, Akana SF, Bornstein SR, Eisenhofer G, Dallman MF, Ingraham HA. PMID: 11121051.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    61. Gene dosage effects of steroidogenic factor 1 (SF-1) in adrenal development and the stress. Endocr Res. 2000 Nov; 26(4):515-6. Bland ML, Jamieson C, Akana S, Dallman M, Ingraham HA. PMID: 11196422.
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