Onur Cil, MD, PhD

Title(s)Associate Professor, Pediatrics
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #1244
San Francisco CA 94143
ORCID ORCID Icon0000-0001-5178-0199 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Hacettepe University, Ankara/TurkeyM.D.Faculty of Medicine
    Hacettepe University, Ankara/TurkeyPh.D.Pharmacology
    Hacettepe University, Ankara/TurkeyResidencyPediatrics
    University of California, San FranciscoFellowshipPediatric nephrology
    Collapse Awards and Honors
    American Heart Association2020Stephanie Watts Career Development Award

    Collapse Overview 
    Collapse Overview
    Dr. Onur Cil is a pediatric nephrologist and physician-scientist. Cil Lab’s research focus is small molecule drug discovery and drug repurposing for treatment of renal, gastrointestinal and cardiovascular diseases. Ultimate goal of our research is advancing our discoveries to clinical trials and establishing better and safer treatments. Our research is focused on membrane proteins including calcium-sensing receptor (CaSR), SLC26A3 (DRA), SLC26A4 (Pendrin), SLC26A6 (PAT1), CFTR, TMEM16A and urea transporters.

    Collapse Research 
    Collapse Research Activities and Funding
    Roles of CaSR in ocular surface health and disease
    NIH R01EY036139May 1, 2024 - Apr 30, 2028
    Role: Principal Investigator
    SLC26A3 (DRA) Inhibitors for Treatment of Hyperoxaluria and Nephrolithiasis
    NIH R01DK126070Jul 22, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Novel small-molecule therapies for CF
    NIH P30DK072517Aug 1, 2005 - May 31, 2023
    Role: Director of Animal Pharmacology & Models Core

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. DRA involvement in linaclotide stimulated bicarbonate secretion during loss of CFTR function. JCI Insight. 2024 Jun 13. Sarthi JB, Trumbull AM, Abazari SM, van Unen V, Chan JE, Jiang Y, Gammons J, Anderson MO, Cil O, Kuo CJ, Sellers ZM. PMID: 38869953.
      View in: PubMed   Mentions:    Fields:    
    2. Calcium-sensing receptor (CaSR) modulates ocular surface chloride transport and its inhibition promotes ocular surface hydration. Ocul Surf. 2024 Jun 11; 34:30-37. Pasricha ND, Lindgren ES, Yan R, Kuo YM, Chan M, Verkman AS, Chu T, Yottasan P, de Souza Goncalves L, Cil O. PMID: 38871216.
      View in: PubMed   Mentions:    Fields:    
      View in: Publisher Site   Mentions:
    4. Crypt and Villus Enterochromaffin Cells are Distinct Stress Sensors in the Gut. bioRxiv. 2024 Apr 25. Touhara KK, Rossen ND, Deng F, Chu T, Harrington AM, Garcia Caraballo S, Brizuela M, O'Donnell T, Cil O, Brierley SM, Li Y, Julius D. PMID: 38370814; PMCID: PMC10871270.
      View in: PubMed   Mentions:
    5. Key role of down-regulated in adenoma (SLC26A3) chloride/bicarbonate exchanger in linaclotide-stimulated intestinal bicarbonate secretion upon loss of CFTR function. bioRxiv. 2024 Apr 22. Sarthi JB, Trumbull AM, Abazari SM, van Unen V, Chan JE, Jiang Y, Gammons J, Anderson MO, Cil O, Kuo CJ, Sellers ZM. PMID: 37205513; PMCID: PMC10187319.
      View in: PubMed   Mentions:
    6. Substituted 4-methylcoumarin inhibitors of SLC26A3 (DRA) for treatment of constipation and hyperoxaluria. RSC Med Chem. 2024 May 22; 15(5):1731-1736. Ahmadi M, de Souza Goncalves L, Verkman AS, Cil O, Anderson MO. PMID: 38784456; PMCID: PMC11110725.
      View in: PubMed   Mentions:
    7. Incidence and Mitigation of Corneal Pseudomicrocysts Induced by Antibody-Drug Conjugates (ADCs). Curr Ophthalmol Rep. 2024 Jun; 12(2):13-22. Lindgren ES, Yan R, Cil O, Verkman AS, Chan MF, Seitzman GD, Farooq AV, Huppert LA, Rugo HS, Pohlmann PR, Lu J, Esserman LJ, Pasricha ND. PMID: 38756824; PMCID: PMC11095972.
      View in: PubMed   Mentions:
    8. Mg2+ supplementation treats secretory diarrhea in mice by activating calcium-sensing receptor in intestinal epithelial cells. J Clin Invest. 2024 Jan 16; 134(2). de Souza Goncalves L, Chu T, Master R, Chhetri PD, Gao Q, Cil O. PMID: 37962961; PMCID: PMC10786700.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment. Transl Res. 2024 03; 265:17-25. Yottasan P, Chu T, Chhetri PD, Cil O. PMID: 37990828; PMCID: PMC10922239.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Repurposing calcium-sensing receptor activator drug cinacalcet for ADPKD treatment. Translational Research. 2023 Oct 1. Yottasan YP, Chu CT, Chhetri CP, Cil CO. .
      View in: Publisher Site   Mentions:
    11. Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders. RSC Med Chem. 2023 Nov 15; 14(11):2342-2347. Chu T, Karmakar J, Haggie PM, Tan JA, Master R, Ramaswamy K, Verkman AS, Anderson MO, Cil O. PMID: 37974969; PMCID: PMC10650448.
      View in: PubMed   Mentions:
    12. Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas. Transl Res. 2024 01; 263:45-52. Chu T, Yottasan P, Goncalves LS, Oak AA, Lin R, Tse M, Donowitz M, Cil O. PMID: 37678755.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    13. Structure of human NCC: insights into the inhibition mechanism of thiazides. Signal Transduct Target Ther. 2023 07 03; 8(1):257. de Souza Goncalves L, Yottasan P, Cil O. PMID: 37394514; PMCID: PMC10315395.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Case report: Short-term eculizumab use in atypical HUS associated with Lemierre's syndrome and post-infectious glomerulonephritis. Front Med (Lausanne). 2023; 10:1167806. Sadiq S, Urisman A, Cil O. PMID: 37206472; PMCID: PMC10189804.
      View in: PubMed   Mentions:
    15. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 05; 249:115149. Cil O, Anderson MO, de Souza Goncalves L, Tan JA, Haggie PM, Verkman AS. PMID: 36724632; PMCID: PMC10124120.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    16. Genetic testing in children with nephrolithiasis and nephrocalcinosis. Pediatr Nephrol. 2023 08; 38(8):2615-2622. Gefen AM, Sethna CB, Cil O, Perwad F, Schoettler M, Michael M, Angelo JR, Safdar A, Amlie-Wolf L, Hunley TE, Ellison JS, Feig D, Zaritsky J. PMID: 36688940.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Selective isoxazolopyrimidine PAT1 (SLC26A6) inhibitors for therapy of intestinal disorders. RSC Medicinal Chemistry. 2023 Jan 1. Chu CT, Karmakar KJ, Haggie HP, Tan TJ, Master MR, Ramaswamy RK, Verkman VA, Anderson AM, Cil CO. .
      View in: Publisher Site   Mentions:
    18. Repurposing Calcium-Sensing Receptor Activator Cinacalcet for Autosomal Dominant Polycystic Kidney Disease Treatment. Journal of the American Society of Nephrology. 2022 Nov 1; 33(11S):419-419. Yottasan YP, Chu CQ, Cil CO. .
      View in: Publisher Site   Mentions:
    19. Ocular Surface Ion Transport and Dry Eye Disease. Curr Ophthalmol Rep. 2022 Dec; 10(4):188-197. Lindgren ES, Cil O, Verkman AS, Pasricha ND. PMID: 38213468; PMCID: PMC10783585.
      View in: PubMed   Mentions:
    20. Small-molecule inhibitor of intestinal anion exchanger SLC26A3 for treatment of hyperoxaluria and nephrolithiasis. JCI Insight. 2022 07 08; 7(13). Cil O, Chu T, Lee S, Haggie PM, Verkman AS. PMID: 35608921; PMCID: PMC9310519.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    21. Cystinuria: An Overview of Diagnosis and Medical Management. Turk Arch Pediatr. 2022 Jul; 57(4):377-384. Sadiq S, Cil O. PMID: 35822468; PMCID: PMC9317473.
      View in: PubMed   Mentions:
    22. Lubiprostone is non-selective activator of cAMP-gated ion channels and Clc-2 has a minor role in its prosecretory effect in intestinal epithelial cells. Mol Pharmacol. 2022 Jun 09. Oak AA, Chu T, Yottasan P, Chhetri PD, Zhu J, Du Bois J, Cil O. PMID: 35680165; PMCID: PMC9341254.
      View in: PubMed   Mentions: 5     Fields:    
    23. SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. JCI Insight. 2021 06 08; 6(11). Cil O, Haggie PM, Tan JT, Rivera AA, Verkman AS. PMID: 34100381; PMCID: PMC8262356.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    24. A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats. Kidney Int. 2021 08; 100(2):311-320. Cil O, Chen X, Askew Page HR, Baldwin SN, Jordan MC, Myat Thwe P, Anderson MO, Haggie PM, Greenwood IA, Roos KP, Verkman AS. PMID: 33836171; PMCID: PMC8319106.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    25. Repurposing calcium-sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas. JCI Insight. 2021 02 22; 6(4). Oak AA, Chhetri PD, Rivera AA, Verkman AS, Cil O. PMID: 33400691; PMCID: PMC7934922.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    26. Small Molecule Inhibitor of TMEM16A Chloride Channel Blocks Vascular Smooth Muscle Contraction and Lowers Blood Pressure in Spontaneously Hypertensive Rats. Journal of the American Society of Nephrology. 2020 Oct 1; 31(10S):39-39. Cil CO, Chen CX, Page PH, Jordan JM, Thwe TP, Baldwin BS, Anderson AM, Greenwood GI, Roos RK, Verkman VA. .
      View in: Publisher Site   Mentions:
    27. α-Lipoic Acid (ALA) Improves Cystine Solubility in Cystinuria: Report of 2 Cases. Pediatrics. 2020 05; 145(5). Cil O, Perwad F. PMID: 32245805.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    28. 4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation. J Med Chem. 2019 09 12; 62(17):8330-8337. Lee S, Cil O, Haggie PM, Verkman AS. PMID: 31389695; PMCID: PMC7034394.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    29. Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A. FASEB J. 2019 10; 33(10):11247-11257. Cil O, Anderson MO, Yen R, Kelleher B, Huynh TL, Seo Y, Nilsen SP, Turner JR, Verkman AS. PMID: 31299174; PMCID: PMC6766656.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    30. Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea. FASEB J. 2019 10; 33(10):10924-10934. Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. PMID: 31268738; PMCID: PMC6766649.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    31. Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI Insight. 2019 02 21; 4(4). Duan T, Cil O, Thiagarajah JR, Verkman AS. PMID: 30668547; PMCID: PMC6478423.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    32. SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. JCI Insight. 2018 07 26; 3(14). Haggie PM, Cil O, Lee S, Tan JA, Rivera AA, Phuan PW, Verkman AS. PMID: 30046015; PMCID: PMC6124422.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    33. Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1. J Med Chem. 2018 04 12; 61(7):3209-3217. Lee S, Cil O, Diez-Cecilia E, Anderson MO, Verkman AS. PMID: 29589443; PMCID: PMC5976253.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    34. Monogenic Causes of Proteinuria in Children. Front Med (Lausanne). 2018; 5:55. Cil O, Perwad F. PMID: 29594119; PMCID: PMC5858124.
      View in: PubMed   Mentions: 6  
    35. Substituted 2-Acylaminocycloalkylthiophene-3-carboxylic Acid Arylamides as Inhibitors of the Calcium-Activated Chloride Channel Transmembrane Protein 16A (TMEM16A). J Med Chem. 2017 06 08; 60(11):4626-4635. Truong EC, Phuan PW, Reggi AL, Ferrera L, Galietta LJV, Levy SE, Moises AC, Cil O, Diez-Cecilia E, Lee S, Verkman AS, Anderson MO. PMID: 28493701; PMCID: PMC5516794.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    36. High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. J Med Chem. 2017 03 23; 60(6):2401-2410. Son JH, Zhu JS, Phuan PW, Cil O, Teuthorn AP, Ku CK, Lee S, Verkman AS, Kurth MJ. PMID: 28230981; PMCID: PMC5463557.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    37. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. FASEB J. 2017 02; 31(2):751-760. Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. PMID: 27871064; PMCID: PMC5240666.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    38. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Transl Res. 2017 04; 182:14-26.e4. Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJV, Donowitz M, Kurth MJ, Verkman AS. PMID: 27815136; PMCID: PMC5453637.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    39. Small-Molecule Inhibitors of Pendrin Potentiate the Diuretic Action of Furosemide. J Am Soc Nephrol. 2016 Dec; 27(12):3706-3714. Cil O, Haggie PM, Phuan PW, Tan JA, Verkman AS. PMID: 27153921; PMCID: PMC5118489.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    40. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):317-327. Cil O, Phuan PW, Lee S, Tan J, Haggie PM, Levin MH, Sun L, Thiagarajah JR, Ma T, Verkman AS. PMID: 27127798; PMCID: PMC4844355.
      View in: PubMed   Mentions: 29     Fields:    
    41. A Turkish BCS1L mutation causes GRACILE-like disorder. Turk J Pediatr. 2016; 58(6):658-661. Serdaroglu E, Takci S, Kotarsky H, Çil O, Utine E, Yigit S, Fellman V. PMID: 29090881.
      View in: PubMed   Mentions: 3     Fields:    
    42. MCP1 2518 A/G polymorphism affects progression of childhood focal segmental glomerulosclerosis. Ren Fail. 2015; 37(9):1435-9. Besbas N, Kalyoncu M, Cil O, Ozgul RK, Bakkaloglu A, Ozaltin F. PMID: 26335292.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    43. Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats. Kidney Int. 2015 Aug; 88(2):311-20. Cil O, Esteva-Font C, Tas ST, Su T, Lee S, Anderson MO, Ertunc M, Verkman AS. PMID: 25993324; PMCID: PMC4523423.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    44. Genetic abnormalities and prognosis in patients with congenital and infantile nephrotic syndrome. Pediatr Nephrol. 2015 Aug; 30(8):1279-87. Cil O, Besbas N, Duzova A, Topaloglu R, Peco-Antic A, Korkmaz E, Ozaltin F. PMID: 25720465.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    45. Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors. FASEB J. 2014 Sep; 28(9):3878-90. Esteva-Font C, Cil O, Phuan PW, Su T, Lee S, Anderson MO, Verkman AS. PMID: 24843071; PMCID: PMC4139901.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    46. Small-molecule inhibitors of urea transporters. Subcell Biochem. 2014; 73:165-77. Verkman AS, Esteva-Font C, Cil O, Anderson MO, Li F, Li M, Lei T, Ren H, Yang B. PMID: 25298345; PMCID: PMC4306426.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    47. A novel mutation in protein C gene (PROC) causing severe phenotype in neonatal period. Pediatr Blood Cancer. 2014 Apr; 61(4):763-4. Unal S, Gumruk F, Yigit S, Tuncer M, Tavil B, Cil O, Takci S, Urata M, Hotta T, Kang D, Cetin M. PMID: 24115609.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    48. Protective effect of coenzyme Q10 in paclitaxel-induced peripheral neuropathy in rats. Neurosciences (Riyadh). 2013 Apr; 18(2):133-7. Celebi N, Cil H, Cil O, Canbay O, Onur R, Aypar U. PMID: 23545610.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    49. Role of CXCR1 (CKR-1) in inflammation of experimental mesangioproliferative glomerulonephritis. Ren Fail. 2013; 35(3):380-5. Ozaltin F, Besbas N, Iskit AB, Cil O, Akcoren Z, Kale G, Bakkaloglu A. PMID: 23336303.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    50. The diuretic effect of urea analog dimethylthiourea in female Wistar rats. Hum Exp Toxicol. 2012 Oct; 31(10):1050-5. Cil O, Ertunc M, Onur R. PMID: 23023029.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    51. Endothelial dysfunction and increased responses to renal nerve stimulation in rat kidneys during rhabdomyolysis-induced acute renal failure: role of hydroxyl radical. Ren Fail. 2012; 34(2):211-20. Cil O, Ertunc M, Gucer KS, Ozaltin F, Iskit AB, Onur R. PMID: 22229548.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    52. Family history of renal disease severity predicts the mutated gene in ADPKD. J Am Soc Nephrol. 2009 Aug; 20(8):1833-8. Barua M, Cil O, Paterson AD, Wang K, He N, Dicks E, Parfrey P, Pei Y. PMID: 19443633; PMCID: PMC2723982.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    53. Evidence for pathogenicity of atypical splice mutations in autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 2009 Feb; 4(2):442-9. Wang K, Zhao X, Chan S, Cil O, He N, Song X, Paterson AD, Pei Y. PMID: 19158373; PMCID: PMC2637591.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
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